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<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUT4</accession>
    <name>A0A074YUT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600013">
        <property type="protein sequence ID" value="KER18541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177712.1">
        <property type="nucleotide sequence ID" value="XM_009179448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUT4"/>
    <dbReference type="GeneID" id="20326403"/>
    <dbReference type="KEGG" id="ovi:T265_12235"/>
    <dbReference type="CTD" id="20326403"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="49"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11084" checksum="86179D34EBCD6429" modified="2014-10-01" version="1" fragment="single">AFTFSTHRTSTGCERGNENGRKTSHQCGARNPVDDTTRTPKPVDRCQPETRDQLGEKCNFTPQTHGHTRTSTQPDVHKQITFQVYRVSLVNCCPASSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWN1</accession>
    <name>A0A074YWN1_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597340">
        <property type="protein sequence ID" value="KER19088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177164.1">
        <property type="nucleotide sequence ID" value="XM_009178900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWN1"/>
    <dbReference type="STRING" id="6198.A0A074YWN1"/>
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    <dbReference type="KEGG" id="ovi:T265_15666"/>
    <dbReference type="CTD" id="20329831"/>
    <dbReference type="OrthoDB" id="6259343at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="28225" checksum="7E3B37411F6508DD" modified="2014-10-01" version="1" fragment="single">MRRRVGRYRDDPVIAPVAHPLDIWALARYLVWEVMGLPVTMATEAPTDHRHRTVVPEADQDTNAHQMGQPPPDRLEPVSPPRAPGREPLPLPPPAAGYRGSPMPDLVPPPREYPPKGAPPPRQRYHKYENYGEYDDYREPVAAPAPRFSEYYDNYGNYSGGKAIGPLPLEGMTEGTIMVTMIMVQITGRLPHHDDYVVNPVGLAKDDIYIRIEKARAAFASLRHLWCRRDIRFSVKCRVYNAAMRSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY33</accession>
    <name>A0A074YY33_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL611475">
        <property type="protein sequence ID" value="KER18097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178156.1">
        <property type="nucleotide sequence ID" value="XM_009179892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY33"/>
    <dbReference type="GeneID" id="20330457"/>
    <dbReference type="KEGG" id="ovi:T265_16292"/>
    <dbReference type="CTD" id="20330457"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13997" checksum="3A8EAD093D8F7867" modified="2014-10-01" version="1" fragment="single">MGKTGRGLSNGEKMLNLVSDNAKQVSVFLHNGVGAKRISVVAGNMNPESYTITLQVSAFHMSAVSAILRNISRCVIVDTLLLRALSRSEKTCDLSIKFKQHWVRALDDLRFQTPISSCFHELACFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYA1</accession>
    <name>A0A074YYA1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL608773">
        <property type="protein sequence ID" value="KER18147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6198.A0A074YYA1"/>
    <dbReference type="GeneID" id="20330428"/>
    <dbReference type="KEGG" id="ovi:T265_16263"/>
    <dbReference type="CTD" id="20330428"/>
    <dbReference type="OrthoDB" id="10455972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11719" checksum="77B4D0F870608D2B" modified="2014-10-01" version="1" fragment="single">MNDRVNTCVIKCVEMSQAMQQEAIAVSTTALQEYNIEKDVAKYIKKEVELLFFYSDPDDSSMQRACRNYRRSLCLAYMSIFFVELLSLSCTARDFPMTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ57</accession>
    <name>A0A074YZ57_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600603">
        <property type="protein sequence ID" value="KER18497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177756.1">
        <property type="nucleotide sequence ID" value="XM_009179492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ57"/>
    <dbReference type="GeneID" id="20326423"/>
    <dbReference type="KEGG" id="ovi:T265_12255"/>
    <dbReference type="CTD" id="20326423"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11137" checksum="7C1BA5E56933A13C" modified="2014-10-01" version="1">MFGPVGCEQAIVTCDCFILRQSQRLDSISRISSNMGELEPQNYTKRHEECPDLHSLFPSSVLYRGAVSCYVCHTEPHRWKPNAVCIKQRVEQSHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ96</accession>
    <name>A0A074YZ96_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597107">
        <property type="protein sequence ID" value="KER19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176252.1">
        <property type="nucleotide sequence ID" value="XM_009177988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20325525"/>
    <dbReference type="KEGG" id="ovi:T265_11357"/>
    <dbReference type="CTD" id="20325525"/>
    <dbReference type="OrthoDB" id="6358690at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF34">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="524" mass="59054" checksum="7A23668E06160098" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZI8</accession>
    <name>A0A074YZI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial folate transporter/carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597084">
        <property type="protein sequence ID" value="KER20166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176082.1">
        <property type="nucleotide sequence ID" value="XM_009177818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZI8"/>
    <dbReference type="STRING" id="6198.A0A074YZI8"/>
    <dbReference type="GeneID" id="20325387"/>
    <dbReference type="KEGG" id="ovi:T265_11219"/>
    <dbReference type="CTD" id="20325387"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33020" checksum="ACD97B19A7CC0362" modified="2014-10-01" version="1">MRRPGAAHSVAWKHRNREIWVQVQPYEETVNRGTFRTLTDVVKIRGLRGLYLGLAPNVIGSSGSWGLYFLLYAALRSSLQKGDATKPLTALEYFGCGALAGSLTLTVMNPIWVIKTRLCLQYEQPASRHSVQPSISLRTLSTWEALTNLWRYEGITGLYKGYLPGLVGVSHGAIQFMLYEKIRNAYNERCRHRPVNAKLTSWEYFTFACLSKLAATSLTYPYQVVRTRLQDQHRQQRGVIQIIQTMYRYEGLLSFYKGLTPNLLRVTPACAVTFVVYEQMIAVLNKSFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZV4</accession>
    <name>A0A074YZV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598182">
        <property type="protein sequence ID" value="KER18742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177511.1">
        <property type="nucleotide sequence ID" value="XM_009179247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZV4"/>
    <dbReference type="GeneID" id="20330018"/>
    <dbReference type="KEGG" id="ovi:T265_15853"/>
    <dbReference type="CTD" id="20330018"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7936" checksum="B8811B9E04B74F8F" modified="2014-10-01" version="1" fragment="single">MFQSTSFAKGLERFTTAGDSSGHINSRLDNMNREILSDANLDVDMVHPRQTTTWTSDRNEPWICEWETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z083</accession>
    <name>A0A074Z083_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597067">
        <property type="protein sequence ID" value="KER20333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175926.1">
        <property type="nucleotide sequence ID" value="XM_009177662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z083"/>
    <dbReference type="STRING" id="6198.A0A074Z083"/>
    <dbReference type="GeneID" id="20325266"/>
    <dbReference type="KEGG" id="ovi:T265_11098"/>
    <dbReference type="CTD" id="20325266"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="273"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="661" mass="76998" checksum="0D348B68F82562B8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0A9</accession>
    <name>A0A074Z0A9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597507">
        <property type="protein sequence ID" value="KER18912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177341.1">
        <property type="nucleotide sequence ID" value="XM_009179077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0A9"/>
    <dbReference type="GeneID" id="20329920"/>
    <dbReference type="KEGG" id="ovi:T265_15755"/>
    <dbReference type="CTD" id="20329920"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="16246" checksum="7D804C60A90BD51A" modified="2014-10-01" version="1" fragment="single">QRPEPASVQPPVNFGLSITGSLYTTISFAYTAAFYGPIVERSIKHLNVNGALGKPNGIRPNCIWIYDSKSRWNKVNTMPVTTRNPFGDSVCCSQLCERIALIEISHVCPRKRRKLLMCTQCWNFESETFIKIPQEWDFKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0X0</accession>
    <name>A0A074Z0X0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597039">
        <property type="protein sequence ID" value="KER20608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175656.1">
        <property type="nucleotide sequence ID" value="XM_009177392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0X0"/>
    <dbReference type="STRING" id="6198.A0A074Z0X0"/>
    <dbReference type="GeneID" id="20329446"/>
    <dbReference type="KEGG" id="ovi:T265_15281"/>
    <dbReference type="CTD" id="20329446"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="18717" checksum="49BF63D88D4F542B" modified="2014-10-01" version="1" fragment="single">MLGYGIAKAAVHQLTKSLAAEGSGLPAGVHVTAILPFCSLYAFSLIALSLILGMLGYGIAKAAVHQLTKSLAAEGSGLPAGVHVTAILPMQCDQPICQSPSQRSVSKPSPRKINQDNLLLTRKNRIHVSSFTIRTVSNLATGISCWNLASSLSLSMYIMSPKRADKTPLLSCTSSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1B2</accession>
    <name>A0A074Z1B2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597264">
        <property type="protein sequence ID" value="KER19267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176987.1">
        <property type="nucleotide sequence ID" value="XM_009178723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1B2"/>
    <dbReference type="GeneID" id="20326070"/>
    <dbReference type="KEGG" id="ovi:T265_11902"/>
    <dbReference type="CTD" id="20326070"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16266" checksum="125E24DCCE46C0A0" modified="2014-10-01" version="1">MGIGLDSKDGDASECTQYYLVTRSGSIPSTGSSKKFFGGEFEQRQSQTKNEVHALQTRGGIEKTVKKRIAPLKMYFIMIRLMPLHPALYRPHDTAVTFPVAREHHKQEIQLSSRGTATPVAMVYVTEKWGIGELIAGYCKRLPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1C0</accession>
    <name>A0A074Z1C0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597260">
        <property type="protein sequence ID" value="KER19277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176974.1">
        <property type="nucleotide sequence ID" value="XM_009178710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1C0"/>
    <dbReference type="STRING" id="6198.A0A074Z1C0"/>
    <dbReference type="GeneID" id="20326061"/>
    <dbReference type="KEGG" id="ovi:T265_11893"/>
    <dbReference type="CTD" id="20326061"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="31868" checksum="105A8E22EA4890F2" modified="2014-10-01" version="1">MQPEHPVSPPWRFLVHGDPGPQCICTSKGSTTTPKALVISRFSKIAQNSVRLILHSIDLGRVCSTLSSRLQNNLKCQLFTRLDKMPIKIVILVLQERKSGDTGFTKISVPLHPADVNPYIPDLLRTHPGSGFIGDNLNSYRRQPQPDPTLSPRCSPSPSPHVADSNAFLSTARHVPVESILNPSTAKAQDPESRTHPFPPTPPAPPVCIRCRDPIMDHYLFRIRGQAWHEACAVCSVCSVKLSDVCFVHEGQLFCRKDYDRFNNVVLSQPPAGCMTSMCQKTATDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1N1</accession>
    <name>A0A074Z1N1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597007">
        <property type="protein sequence ID" value="KER20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175304.1">
        <property type="nucleotide sequence ID" value="XM_009177040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1N1"/>
    <dbReference type="STRING" id="6198.A0A074Z1N1"/>
    <dbReference type="GeneID" id="20324786"/>
    <dbReference type="KEGG" id="ovi:T265_10618"/>
    <dbReference type="CTD" id="20324786"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="19363" checksum="430274ADC2E5F7F9" modified="2014-10-01" version="1">MGHSMDWSPQMEIELFRAIMKYKPVGADRHFQMIYIKSVLNSRLHSSSLTTNDIWQKLESLYNMDELHESEVNPFQSKMREFGLPDEFSTLKAQPFPRVKSYFGDSATGPSDSAFFICCLYTHTDAPHPKRLRKSLRSTDDAAGLKIGDEVKVDDTAETPTRKNRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z272</accession>
    <name>A0A074Z272_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596995">
        <property type="protein sequence ID" value="KER21093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175159.1">
        <property type="nucleotide sequence ID" value="XM_009176895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z272"/>
    <dbReference type="STRING" id="6198.A0A074Z272"/>
    <dbReference type="GeneID" id="20324675"/>
    <dbReference type="KEGG" id="ovi:T265_10507"/>
    <dbReference type="CTD" id="20324675"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="262" mass="28891" checksum="1935564CDBA902C8" modified="2014-10-01" version="1">MLSLLFAFIYRDDSLEATSLLYSLLCHSSVTHYNSLALVDISKAFDSVSHDTTVRSTEVFGELPPLVRYISQSYENAVAAFPNSKVHCGRQGDPLSALLFNMAMDEAASPALTELEIVMLDWVGKLLKLPKQFLHEGNQGGGVIQCSASDCVLLSMLAARHKAIIQYRHLFASEPNPGTAVLGRLVAYASTLAHSCVEKAGMICFVYFRQIKPDSDFAMQGSALQEAIERRTWNPVESLVCDVLRQLNVLHQAASCFSHYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2C4</accession>
    <name>A0A074Z2C4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175114.1">
        <property type="nucleotide sequence ID" value="XM_009176850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2C4"/>
    <dbReference type="GeneID" id="20324637"/>
    <dbReference type="KEGG" id="ovi:T265_10469"/>
    <dbReference type="CTD" id="20324637"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13001" checksum="BCF1317D5BDA75C9" modified="2014-10-01" version="1">MSPTGLSPEGLSTNRRMDGQKQTRQRKEESHPGPEKSINACLAAKSYGVLKGPTILFVYSGDFRREQTYPELQKSGKVSVRRNSTRIPLYHWQSGATAEKPIPRKISRKFGTLAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3C5</accession>
    <name>A0A074Z3C5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597104">
        <property type="protein sequence ID" value="KER20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176237.1">
        <property type="nucleotide sequence ID" value="XM_009177973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3C5"/>
    <dbReference type="STRING" id="6198.A0A074Z3C5"/>
    <dbReference type="GeneID" id="20325510"/>
    <dbReference type="KEGG" id="ovi:T265_11342"/>
    <dbReference type="CTD" id="20325510"/>
    <dbReference type="OrthoDB" id="6280626at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="744" mass="81303" checksum="444A9E2B83368687" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z484</accession>
    <name>A0A074Z484_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_11094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597067">
        <property type="protein sequence ID" value="KER20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175920.1">
        <property type="nucleotide sequence ID" value="XM_009177656.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z484"/>
    <dbReference type="GeneID" id="20325262"/>
    <dbReference type="KEGG" id="ovi:T265_11094"/>
    <dbReference type="CTD" id="20325262"/>
    <dbReference type="OrthoDB" id="1902038at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033253">
        <property type="entry name" value="CFAP45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15504">
        <property type="entry name" value="NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="9">
        <location>
            <begin position="37"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="411" mass="49833" checksum="063D0005B69A6D30" modified="2014-10-01" version="1">MHQYDLARTKNEKLTDLEEEARKQAEVLLQKALEQRQDQEDEIRALNELILNAKIQAIRDEQILEKKQIQKELNEEELRLDNMMELERQNAIRIQEEIDKQRQEQEMLGACEVLNQIQQNRQDRLLELERNEQENALVQQRISEELMKEIANREVKRQMQNKIRMDLNEANEAMRKHREEEKERDRLFDLKILEIQRQKAEREAAYEAEQAQVRLEKELEIARLRALQERASDEAAERDALRAKRAAEAREREWRRKERADALKKKETEDELKRARIARRKXVYWPLRLDENFGLRKKFQCEPIVCIIDFRRQKELMENDQRERAEADQKNKKYAEEIRKQICLKEQERIAERNAFFEEGVRLEEESRLRRMRLAEAKERKLRELREAGIPEKYLHQVERKVLHMGSVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4H8</accession>
    <name>A0A074Z4H8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607757">
        <property type="protein sequence ID" value="KER18175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178078.1">
        <property type="nucleotide sequence ID" value="XM_009179814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4H8"/>
    <dbReference type="STRING" id="6198.A0A074Z4H8"/>
    <dbReference type="GeneID" id="20326519"/>
    <dbReference type="KEGG" id="ovi:T265_12351"/>
    <dbReference type="CTD" id="20326519"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10077" checksum="55296B0EC478C5C3" modified="2014-10-01" version="1">MFAHVVLHTIADISAEVEVRPGSIILRPYEPLRLECISHNPLIRPSARFGDGRPLEDDPRFQLRRILPNHIEILSTTGLTERDGNLTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5N0</accession>
    <name>A0A074Z5N0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173797.1">
        <property type="nucleotide sequence ID" value="XM_009175533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5N0"/>
    <dbReference type="GeneID" id="20323627"/>
    <dbReference type="KEGG" id="ovi:T265_09458"/>
    <dbReference type="CTD" id="20323627"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18830" checksum="D569C0EFD869E024" modified="2014-10-01" version="1">MHSCLPPNETAAATTTVRRVSGLGNLAVSQPSCLLRVARQLGTESVLQLNDFFCKPERLVESQTVVASRSHMSSQICVYHYSAQSYRLLQHAIARISSIQFLHPSLHSRGRVKVYGKLSPEFTTSSDGRQGCPLLPFLFNFVIDTIMEDSLPASKVCGIEVPPGRLLTDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6H3</accession>
    <name>A0A074Z6H3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173491.1">
        <property type="nucleotide sequence ID" value="XM_009175227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6H3"/>
    <dbReference type="GeneID" id="20323393"/>
    <dbReference type="KEGG" id="ovi:T265_09214"/>
    <dbReference type="CTD" id="20323393"/>
    <dbReference type="OrthoDB" id="3174329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="450" mass="49823" checksum="C7014746F124054D" modified="2014-10-01" version="1">MTQPPPGFPFYPLANPKGTEFKCEVCGKPAFIQCAICRVTYYCGTEHQKIDWVGIHEKICSSLMVIRKPVPFIASEDERRSLRDELQDKNIDMVALTQLVGQKLLFQGKPEEAVPAALQCLKFTADAYGLASVELVSPYLILAESSIGLGRLCQAEAYLAQAQWTMLKTQHECSNAIRSQLHRKLGLLYAAKGDYEAALESLAKDIFYASCEYGTDHIRTAGGYFQMAEVFYAIHQRDQQRCKEALADPKASQGPYSLIGPSATPQISGGPKPMPDNPILGGVHCCVPNPPCNTLSLGSDQPISPPKDKLPVADSLYARVVDIWCDHLAGIVRSLTYRPLVPEGIGAVVAEITQEKLETLVRVNIQHRLQWLGHVLRMPEHRLPRRVLFSVPRSGWRKPRGGQQMTWQKGVKEITKSLGVAGAVCLRGWGSRDPVCAWLETLQEMVANQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6H6</accession>
    <name>A0A074Z6H6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173606.1">
        <property type="nucleotide sequence ID" value="XM_009175342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6H6"/>
    <dbReference type="STRING" id="6198.A0A074Z6H6"/>
    <dbReference type="GeneID" id="20323486"/>
    <dbReference type="KEGG" id="ovi:T265_09313"/>
    <dbReference type="CTD" id="20323486"/>
    <dbReference type="OrthoDB" id="6285467at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="284" mass="32190" checksum="94661BE26027CE5F" modified="2014-10-01" version="1">MDFLPSSRRSLNNPRKKVIPETVKTNARKKQKSKKSKRYAPAPSSDLQDSLVRNVPDVNSAEPSVNLNAPMRSSDCTDEQNTQSPWLSTKRRHRMKTRPPARDHEVVESLAVSSASAIQPTVSGNRETLKFPRDHCLMLFGSKESGEEGAQARYNHDLNLLQGLVDKLADADEPGIRVRRILRLGKRVAGIHRPLKIVFENADAPKHLLSRAWRLKGMDIYIRPDMDPSQRAQLKAAVVELRRRTLEGENDLRIVNFRIVKWRAFINRPVTLTARSQSHSLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6U0</accession>
    <name>A0A074Z6U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597435">
        <property type="protein sequence ID" value="KER18955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177298.1">
        <property type="nucleotide sequence ID" value="XM_009179034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6U0"/>
    <dbReference type="GeneID" id="20326251"/>
    <dbReference type="KEGG" id="ovi:T265_12083"/>
    <dbReference type="CTD" id="20326251"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8774" checksum="169A42CB74DA121B" modified="2014-10-01" version="1">MQPMMKRSTSGGVLKTSRIQLENEKSRTICASFSSEQMITRRRAAAGHRALELPELNPRKVVVSEQQTRADMKNNKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7B2</accession>
    <name>A0A074Z7B2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597337">
        <property type="protein sequence ID" value="KER19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177160.1">
        <property type="nucleotide sequence ID" value="XM_009178896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7B2"/>
    <dbReference type="STRING" id="6198.A0A074Z7B2"/>
    <dbReference type="GeneID" id="20329827"/>
    <dbReference type="KEGG" id="ovi:T265_15662"/>
    <dbReference type="CTD" id="20329827"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34614" checksum="8A27BB947BB03559" modified="2014-10-01" version="1" fragment="single">MRLHYPTHHRGPTRMDFQILYGAYVRPLLEYANQVVYSGRTKDVTLIERVQRAATRIVAGLKSMDYETRLAMLDRFPLDYRRLRGDLILTYALFEQSLANRFFTVDPANTRRGHSERQPLTDRNKTDPGNLGKSLDPVYQSVVYPANELLKPLVPIGDMPKTYPFTLDPFQQQAILCIDNGQSVLVSAHTSAGKTVVAEYAVARSLKRRQRVIYTTPIKALSNQKFREFTAEFKDVGLMTGDITINPEATVLIMTTQHQALSNQKFREFTAEFKDVGLMTGDITINPEATVLIMTTEILRSMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z886</accession>
    <name>A0A074Z886_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597205">
        <property type="protein sequence ID" value="KER19450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176806.1">
        <property type="nucleotide sequence ID" value="XM_009178542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z886"/>
    <dbReference type="GeneID" id="20325950"/>
    <dbReference type="KEGG" id="ovi:T265_11782"/>
    <dbReference type="CTD" id="20325950"/>
    <dbReference type="OrthoDB" id="6266332at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="509" mass="56372" checksum="92E967986A23F8C3" modified="2014-10-01" version="1">MSDHSSSPVTRSRRPKRLPAKTCDDNVLGISWKEERELRKAMYVSLRQKNKPSNGPQLRSRKILHRQASRKHSSTGENGFKVSAVSLRNPVRGREALAKRIAQGELRAAKLRATSRLRSDSTHVGSRSTRANGFHNNKGGLKTENETNFTDIASKYQEPTCSKRPHVNQHKTISVLNVARSIVRARLNGHGSKMLHRPAPHCGPSVVTAASKRPTLMSASNDAKVTSTHYKRPLTPKRSRLRSPIKFAPSAARTNDRNRKSGLPRSERHSVSQPVVTTKSPLKRGTDSSELDAVRPERRLFGSPDAPVCVPVKRTSDIIPRELCQDPEGRPVSVHDFVEFICYHGTPCLDPKLEWFDQTRRRSTASNSPKLPFWGCRSGSNSCPGDDLKTFQRGDSVSTAGSVTQACPSRSAKSEDHLISSPQSRLFSISSKICVAKKLASAHPHDVCIRSPILEIPSEIPSISSKPEDIDLLIPQSTIALPRKPSRNTRGLCVTRNSTGTSRRSRNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z930</accession>
    <name>A0A074Z930_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597148">
        <property type="protein sequence ID" value="KER19730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176527.1">
        <property type="nucleotide sequence ID" value="XM_009178263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z930"/>
    <dbReference type="GeneID" id="20325745"/>
    <dbReference type="KEGG" id="ovi:T265_11577"/>
    <dbReference type="CTD" id="20325745"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="247" mass="28173" checksum="90C2EF414F13BAB9" modified="2014-10-01" version="1">MNPSTKTTKPLPSTIGMIAKEPRTGAHVPNPTTDLQSPTPRFKITANKFLRLRKFGCWSVRRAWQLDCKRFITNRGDIISVGLSGLSAVTSERTTRSRNSELRNLTATNGVIGSKEENHEKQKANQMTRRKRPNPSTSTTYRTAELNAPNEPTRHRRLKPREIHRRPIKLHDDRLQNYQILFRSYIIRGRRGGIHPLNPTLMMSPRLVMKRLQSNCQARRTDQQPNSAPELPTFHNIAAQISASVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAT8</accession>
    <name>A0A074ZAT8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172023.1">
        <property type="nucleotide sequence ID" value="XM_009173759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAT8"/>
    <dbReference type="GeneID" id="20322243"/>
    <dbReference type="KEGG" id="ovi:T265_08064"/>
    <dbReference type="CTD" id="20322243"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9744" checksum="EB3C7CAFF2224887" modified="2014-10-01" version="1">MYCLNGSGEIVDTYHGETAYILSTSTKESEDTNDREKNTKNYNAYDKDMKIRDIVAQIRHHVILSDASGNYQPNAAQLKSRLISKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB43</accession>
    <name>A0A074ZB43_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171923.1">
        <property type="nucleotide sequence ID" value="XM_009173659.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZB43"/>
    <dbReference type="GeneID" id="20322161"/>
    <dbReference type="KEGG" id="ovi:T265_07982"/>
    <dbReference type="CTD" id="20322161"/>
    <dbReference type="OrthoDB" id="9934270at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704052" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="46"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133699" checksum="421CF67A21C98A3C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBF2</accession>
    <name>A0A074ZBF2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171647.1">
        <property type="nucleotide sequence ID" value="XM_009173383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBF2"/>
    <dbReference type="STRING" id="6198.A0A074ZBF2"/>
    <dbReference type="GeneID" id="20328544"/>
    <dbReference type="KEGG" id="ovi:T265_14378"/>
    <dbReference type="CTD" id="20328544"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18237" checksum="5B1F16E59E645920" modified="2014-10-01" version="1" fragment="single">MPSQILKRQSCTDCKTGYWNTRENYYEHTSLPLKSTVIFLLQIGITVYLSQIGSFVPAEEATIGPMDAIYAITCTETLAALDRSSDSLSLNLVLVALRFSTERSLILLDEFAHSIGKASVCVTEASALTTAIIEHLLKSSNPHVVATTHDYDMLNLLKHQADIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCL0</accession>
    <name>A0A074ZCL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171204.1">
        <property type="nucleotide sequence ID" value="XM_009172940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCL0"/>
    <dbReference type="GeneID" id="20321601"/>
    <dbReference type="KEGG" id="ovi:T265_07422"/>
    <dbReference type="CTD" id="20321601"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12671" checksum="9D2368F9CD065542" modified="2014-10-01" version="1">MRKIEAAPSRTLVVVFPTLEEELTTNEHKQCRRGRKNSILPDLAPGDNQNQSQKTAAKGSSLKATNTLRFNVTDTTDLTDDLSGESADCIEAVSNDCFGEITVLTPYRVSRASLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD7</accession>
    <name>A0A074ZDD7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170910.1">
        <property type="nucleotide sequence ID" value="XM_009172646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD7"/>
    <dbReference type="STRING" id="6198.A0A074ZDD7"/>
    <dbReference type="GeneID" id="20321369"/>
    <dbReference type="KEGG" id="ovi:T265_07190"/>
    <dbReference type="CTD" id="20321369"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704055" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="948" mass="108629" checksum="D64B4E6762390057" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDP7</accession>
    <name>A0A074ZDP7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_07235</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170964.1">
        <property type="nucleotide sequence ID" value="XM_009172700.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZDP7"/>
    <dbReference type="GeneID" id="20321414"/>
    <dbReference type="KEGG" id="ovi:T265_07235"/>
    <dbReference type="CTD" id="20321414"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="678"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER25298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1573" mass="172585" checksum="FBA3DE24D85975A7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDU7</accession>
    <name>A0A074ZDU7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170939.1">
        <property type="nucleotide sequence ID" value="XM_009172675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDU7"/>
    <dbReference type="GeneID" id="20321398"/>
    <dbReference type="KEGG" id="ovi:T265_07219"/>
    <dbReference type="CTD" id="20321398"/>
    <dbReference type="OrthoDB" id="6144109at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15962" checksum="E73BC53C0CA88C72" modified="2014-10-01" version="1">MERPSRAEYFEQQMSRPPAGTHLRPRGEVEPWMVNVEPPAASEVYDCICSLKRHRAPGPDDLPPALFKDGGEVLSQRLSDLFACIWKTESVPDNWGESVIVPIFKKGARTIICIRPGDAGFQPTVNRRLPTYIIGQQRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEF6</accession>
    <name>A0A074ZEF6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170702.1">
        <property type="nucleotide sequence ID" value="XM_009172438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEF6"/>
    <dbReference type="STRING" id="6198.A0A074ZEF6"/>
    <dbReference type="GeneID" id="20321196"/>
    <dbReference type="KEGG" id="ovi:T265_07017"/>
    <dbReference type="CTD" id="20321196"/>
    <dbReference type="OrthoDB" id="6238649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131014" checksum="967454CE6F5D4F01" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEX4</accession>
    <name>A0A074ZEX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170483.1">
        <property type="nucleotide sequence ID" value="XM_009172219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEX4"/>
    <dbReference type="STRING" id="6198.A0A074ZEX4"/>
    <dbReference type="GeneID" id="20321016"/>
    <dbReference type="KEGG" id="ovi:T265_06837"/>
    <dbReference type="CTD" id="20321016"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="562" mass="63107" checksum="D7489BBEA62689D5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFK5</accession>
    <name>A0A074ZFK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596810">
        <property type="protein sequence ID" value="KER24422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171819.1">
        <property type="nucleotide sequence ID" value="XM_009173555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFK5"/>
    <dbReference type="GeneID" id="20322077"/>
    <dbReference type="KEGG" id="ovi:T265_07898"/>
    <dbReference type="CTD" id="20322077"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8303" checksum="34784ADC92B391E4" modified="2014-10-01" version="1">MNSHTSKSEEHVSERAVVDENNWSVECGAFGESGTGVSWDDADHVLVSILQENREDSTVNKVNQLTEQPAAVKTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFM4</accession>
    <name>A0A074ZFM4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170178.1">
        <property type="nucleotide sequence ID" value="XM_009171914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFM4"/>
    <dbReference type="GeneID" id="20320789"/>
    <dbReference type="KEGG" id="ovi:T265_06610"/>
    <dbReference type="CTD" id="20320789"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="23854" checksum="647E94D12DBEEBED" modified="2014-10-01" version="1">MKEITIPSPIVNRMFILSGSSSLYVFATSLHEGEQIETSGALTIALLRPTDAPYSAIQRATTPIGGPLMLCRGQHLTSDKQNLERMENCTLASTSCKQLSCFGCWSVRRAWQLDCKRFITNRGDIVSAGLSGFLTVSGSCPAQRTSQRPSTLPELPTFSSIEIGLLFFSSSALPGFGLRTPDMQDERVTTAPPNKKEVGVRLVKSNDDSVQHALVDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFY7</accession>
    <name>A0A074ZFY7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170164.1">
        <property type="nucleotide sequence ID" value="XM_009171900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFY7"/>
    <dbReference type="STRING" id="6198.A0A074ZFY7"/>
    <dbReference type="GeneID" id="20320776"/>
    <dbReference type="KEGG" id="ovi:T265_06597"/>
    <dbReference type="CTD" id="20320776"/>
    <dbReference type="OrthoDB" id="73401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048701">
        <property type="entry name" value="CIP2A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21044">
        <property type="entry name" value="CIP2A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125697" checksum="10154B5C4DF67A98" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG52</accession>
    <name>A0A074ZG52_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596911">
        <property type="protein sequence ID" value="KER22220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174036.1">
        <property type="nucleotide sequence ID" value="XM_009175772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG52"/>
    <dbReference type="GeneID" id="20323810"/>
    <dbReference type="KEGG" id="ovi:T265_09642"/>
    <dbReference type="CTD" id="20323810"/>
    <dbReference type="OrthoDB" id="10429913at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12925" checksum="1216EFC2AE9A3473" modified="2014-10-01" version="1">MFPGNEMCCTRPPHVSVATVFEISRYVHICNALITAWRHHKRVIQLGSRWLKWLESEFTDRKPVVSNPTCASRVRCLGLGDLAVSHPSCNLRVTWQLGTERVLQLNESNQLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGB2</accession>
    <name>A0A074ZGB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171582.1">
        <property type="nucleotide sequence ID" value="XM_009173318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGB2"/>
    <dbReference type="STRING" id="6198.A0A074ZGB2"/>
    <dbReference type="GeneID" id="20321901"/>
    <dbReference type="KEGG" id="ovi:T265_07722"/>
    <dbReference type="CTD" id="20321901"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="497"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="793" mass="86826" checksum="34DEE50596B79F47" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH23</accession>
    <name>A0A074ZH23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173711.1">
        <property type="nucleotide sequence ID" value="XM_009175447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH23"/>
    <dbReference type="STRING" id="6198.A0A074ZH23"/>
    <dbReference type="GeneID" id="20323569"/>
    <dbReference type="KEGG" id="ovi:T265_09400"/>
    <dbReference type="CTD" id="20323569"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="22511" checksum="2240669828DA619B" modified="2014-10-01" version="1">MWETFVSDRLAVAQDGETSLSVLSDEDKAEVDLRSVYVGNVDYGATADELEAHFRACGPINRVTILCNKYTGQPKGFAYIEFDTRDAVEAAMALDESNFRNRALKVLPKRTNVPGMSMTNRPPYMRGGRGRGRGMPFGLRPAYYGGGRMRFPRSRSFTVFAPTILPTTPSDTGILACLCGSLTYLLDRVRAPSAGPAPTCPVVTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH37</accession>
    <name>A0A074ZH37_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169661.1">
        <property type="nucleotide sequence ID" value="XM_009171397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH37"/>
    <dbReference type="STRING" id="6198.A0A074ZH37"/>
    <dbReference type="GeneID" id="20328134"/>
    <dbReference type="KEGG" id="ovi:T265_13967"/>
    <dbReference type="CTD" id="20328134"/>
    <dbReference type="OrthoDB" id="6241411at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37255" checksum="29B2311A5D27D27B" modified="2014-10-01" version="1" fragment="single">WLERELTDRKARGSNPACASRLPLSGLAQLGSIPALVPPSCGMATRHQRGATAGQFTYIKSNMDDVLDAHERTLREHFDPQDAMDNWGQPEEKETVESNWAEAQISDQTGIRITGPPYWITANRNRSAVAPFRCLLPCPEEKETVESNWAEAQISDQTGIRITGPPYWITANRNRSAVAPFRCLTAMPLEICTGAGILPGYPSLDRGNREAEVRFEPRTFRSVDSCSNHLGYLVPIYCQYVTHVTKLIGTMWDEEKVPAEWGKSTVIPVFKKGRRTLCKNHRGISLLAVASKVLSGLILRRLAEPSLTENQAGFRPVRCCIDHIFTLRQILEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH45</accession>
    <name>A0A074ZH45_OPIVI</name>
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        <recommendedName>
            <fullName evidence="1">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175454.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZH45"/>
    <dbReference type="GeneID" id="20323576"/>
    <dbReference type="KEGG" id="ovi:T265_09407"/>
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    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="1">
        <location>
            <begin position="403"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="1">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1506" mass="162728" checksum="22DE2AF473CFF96A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH70</accession>
    <name>A0A074ZH70_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169622.1">
        <property type="nucleotide sequence ID" value="XM_009171358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH70"/>
    <dbReference type="STRING" id="6198.A0A074ZH70"/>
    <dbReference type="GeneID" id="20328124"/>
    <dbReference type="KEGG" id="ovi:T265_13957"/>
    <dbReference type="CTD" id="20328124"/>
    <dbReference type="OrthoDB" id="6276054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="580"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="669"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="962" mass="107800" checksum="60D66A28FDAF9DA6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIQ8</accession>
    <name>A0A074ZIQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596860">
        <property type="protein sequence ID" value="KER23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173041.1">
        <property type="nucleotide sequence ID" value="XM_009174777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIQ8"/>
    <dbReference type="STRING" id="6198.A0A074ZIQ8"/>
    <dbReference type="GeneID" id="20323039"/>
    <dbReference type="KEGG" id="ovi:T265_08860"/>
    <dbReference type="CTD" id="20323039"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="203"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="759" mass="87099" checksum="04645A416938BDAD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ69</accession>
    <name>A0A074ZJ69_OPIVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20320047"/>
    <dbReference type="KEGG" id="ovi:T265_05865"/>
    <dbReference type="CTD" id="20320047"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12787" checksum="16474B6942676F8F" modified="2014-10-01" version="1">MFQTQLTHGHKLCAGTVPDSSSHRRRQSSGKLSHSQSKTPRYPQPEPKKGRSSVWLVVEGSSCVNHVQKSFLSSASDSRDSSAVVTFRAHQASMSTVVLKFPCFHIGEAKCKRMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJC1</accession>
    <name>A0A074ZJC1_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZJC1"/>
    <dbReference type="GeneID" id="20319719"/>
    <dbReference type="KEGG" id="ovi:T265_05537"/>
    <dbReference type="CTD" id="20319719"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13678" checksum="D7FE1833E6E367D7" modified="2014-10-01" version="1">MKMGEVRLNVLLNITFGNDSLNTYSCGPFNKSSPVTYELLYAVVWGGGELSLWLDRQLTDRKAMEVSHMDKSLPENLKRKSFCTLAEWRARRISAYSLRFDSTMPTPKEHRSTQKAWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJQ7</accession>
    <name>A0A074ZJQ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Splicing factor U2af 38 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_06653</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER26017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJQ7"/>
    <dbReference type="STRING" id="6198.A0A074ZJQ7"/>
    <dbReference type="GeneID" id="20320832"/>
    <dbReference type="KEGG" id="ovi:T265_06653"/>
    <dbReference type="CTD" id="20320832"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="102"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER26017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="30693" checksum="1628DA640CAD79FA" modified="2014-10-01" version="1">MFLRPDELFRRVNCSFYFKIGACRHGEQCSRLHNKPSFGQTILLQNLYIAPQNTAQSADGSHINLTEVQAQQIFDEFFEEVFVECEEKYGEIEEMNVCDNLGDHLVGNVYIKIFDEFFEEVFVECEEKYGEIEEMNVCDNLGDHLVGNVYIKFRREEDAEKAVQDLNLRWFGGRPVHAELSPVTDFREACCRQYELGECTRGGFCNFMHLKPISRELCRKLYNRSKKRYGRKRRSRSRSRSRSRDRRRYSRSPGGRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK39</accession>
    <name>A0A074ZK39_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168549.1">
        <property type="nucleotide sequence ID" value="XM_009170285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK39"/>
    <dbReference type="GeneID" id="20319484"/>
    <dbReference type="KEGG" id="ovi:T265_05302"/>
    <dbReference type="CTD" id="20319484"/>
    <dbReference type="OrthoDB" id="10590422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19443" checksum="26308F0EED45FB51" modified="2014-10-01" version="1">MSHLNKWTEHGFISSGRKTEPVRLVHSKLYLDFGIEDDHEAIHTYCLWQILHTHCCHPKCLWQYCTLTVATQRHACRNKAASDLANVRRTESSMPGDMIVSLRIPTLSMCLLSLVLLKEMDAGLWRQAQVIPSDEGGLGPVVAEFFPQRFGKRFIMTGKVNRQTFSDSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLR6</accession>
    <name>A0A074ZLR6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myosin head</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171936.1">
        <property type="nucleotide sequence ID" value="XM_009173672.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLR6"/>
    <dbReference type="GeneID" id="20322170"/>
    <dbReference type="KEGG" id="ovi:T265_07991"/>
    <dbReference type="CTD" id="20322170"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="11">
        <location>
            <begin position="211"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="265"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2119"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2152"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2180" mass="249368" checksum="98662186FA25E0AA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLW6</accession>
    <name>A0A074ZLW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169502.1">
        <property type="nucleotide sequence ID" value="XM_009171238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLW6"/>
    <dbReference type="GeneID" id="20328101"/>
    <dbReference type="KEGG" id="ovi:T265_13934"/>
    <dbReference type="CTD" id="20328101"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="24070" checksum="B0729CF8D61EDBEA" modified="2014-10-01" version="1" fragment="single">NCVAVISILGALSRPQSTQSKAFQYLDKHTHLQINFVFTTDSTESLIYDILQLNVLHTGRLVFQLERYLRYRSIFSLRKLLNYQLFLRLYETWRHREKNFLQLKTGYCIPNWESVPGSVVCAYRLTDIEDAFRGPLHLANGQATKFESSGDKYTHSQVNLVFTRDSTESLVYDVLQLNVLHTGRLMFQLTRYSRYRKKSNLGSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZME2</accession>
    <name>A0A074ZME2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171737.1">
        <property type="nucleotide sequence ID" value="XM_009173473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZME2"/>
    <dbReference type="GeneID" id="20322019"/>
    <dbReference type="KEGG" id="ovi:T265_07840"/>
    <dbReference type="CTD" id="20322019"/>
    <dbReference type="OrthoDB" id="1664504at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704157" evidence="1">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29508" checksum="486235C2F04B1284" modified="2014-10-01" version="1">MRIAEILFWITLTFIATVRPQAKYYPVGKFTEVDDEEFVNIDEYDVEIDEDDLNLDDDEEFPFIEHANDDLDEETEDGDVDSYEAVTPVTPVIEDRTNPRSSNLTNHPVLAFATGTNNLRNRRLITPPLTGAHLRAALVVSCFLGAFPSVLLRAVCLVHAMYVNNSEYSSATDCTDVTNHPVLAFATGTNNLRNRRLITPPLTGAHLRAALVVSCFLGAFPSVLLRAVCLVHAMSVNNSEYSSTTDSTDGTLQGTSLWTCSSLMAMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN03</accession>
    <name>A0A074ZN03_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169122.1">
        <property type="nucleotide sequence ID" value="XM_009170858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN03"/>
    <dbReference type="GeneID" id="20328012"/>
    <dbReference type="KEGG" id="ovi:T265_13845"/>
    <dbReference type="CTD" id="20328012"/>
    <dbReference type="OrthoDB" id="6225150at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8527" checksum="46C657FE4C20933F" modified="2014-10-01" version="1">MRRVIVQCREEKDITVLLEVAKEFGAFLMKPENPERFDIVHFDVPEDRENQVEDFQRKLMETIPYVAVKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN86</accession>
    <name>A0A074ZN86_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167671.1">
        <property type="nucleotide sequence ID" value="XM_009169407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN86"/>
    <dbReference type="GeneID" id="20318807"/>
    <dbReference type="KEGG" id="ovi:T265_04625"/>
    <dbReference type="CTD" id="20318807"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9324" checksum="BF31A8903BA0C65A" modified="2014-10-01" version="1">MKHEKSRSRWNAWHASHGERTVTTPSSRSEPYSVLSNLRFNYKGSQRTRPDTTRTGQNAKIASNIWMALGYAHPIQKPVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNP6</accession>
    <name>A0A074ZNP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171318.1">
        <property type="nucleotide sequence ID" value="XM_009173054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNP6"/>
    <dbReference type="GeneID" id="20321696"/>
    <dbReference type="KEGG" id="ovi:T265_07517"/>
    <dbReference type="CTD" id="20321696"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32888" checksum="A6D1715A8667B552" modified="2014-10-01" version="1">MQLFTPLTNRLWLIDVAFSYTPNYVTYQESTNGSDVITSNPPQEAVQQLVLRRHKRPLIKCVNEAPLVELENADDIFEGEEKVQVFSDELTKVILSFGMHFAPTKCKVMFLDVQLLNTPLTIQGEVLKIVERFTYLGSCISSDCSVRDEVNARICKARVAFANLRTYGVRYQMDFQKLADWPATPITRHNKRLKMTQWLEHEFTDRKVRGSNPSSALRLHMYRLEEPGSILTHVLPLGGMAVRHRKCVTAERLVLPSLHNTTLVMTSVFNTSLPHFRRAIESLIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP44</accession>
    <name>A0A074ZP44_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168661.1">
        <property type="nucleotide sequence ID" value="XM_009170397.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZP44"/>
    <dbReference type="GeneID" id="20319581"/>
    <dbReference type="KEGG" id="ovi:T265_05399"/>
    <dbReference type="CTD" id="20319581"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="481"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="2380"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2339"/>
            <end position="2369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2634"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2341"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="2461"/>
            <end position="2471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3213" mass="360734" checksum="5F66A036BA67A120" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP96</accession>
    <name>A0A074ZP96_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168612.1">
        <property type="nucleotide sequence ID" value="XM_009170348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP96"/>
    <dbReference type="GeneID" id="20319539"/>
    <dbReference type="KEGG" id="ovi:T265_05357"/>
    <dbReference type="CTD" id="20319539"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11884" checksum="A9549570B10A9A2B" modified="2014-10-01" version="1">MKDMKAMNTVDVIRLLGPQWIAEVRKPSHHGKVQSLPDGLLGRGSRDSRSDQDNGRGTPFDWYRLRSNLQYSRQTVHQDLRILYEECGVRAIRTRCFVELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP98</accession>
    <name>A0A074ZP98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166991.1">
        <property type="nucleotide sequence ID" value="XM_009168727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP98"/>
    <dbReference type="GeneID" id="20318267"/>
    <dbReference type="KEGG" id="ovi:T265_04081"/>
    <dbReference type="CTD" id="20318267"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28498" checksum="10512977C4719D74" modified="2014-10-01" version="1">MQLERSLRAGIVTGCPSLDRGSRKAEVCESQCTYQLEKFETDREVIVSEELVKQSVPKIAKGVGISSETQKGIDRDCWWPSRRENTLHSALVQVRDHHPANRTKDCIYKIKYNGCTKVYIGQTAKELHTRTREHSRKIKRPLRNADEYQALLKDSAIAEHALGMGHKIEVLKRELRPTSQRMIAEAVEIAKHSSVNRMEGVELESTRIPLYRTSLGVATADKPGPLEAGPEFGTLAGPSSRRDLIGQQSGPNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPJ0</accession>
    <name>A0A074ZPJ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168510.1">
        <property type="nucleotide sequence ID" value="XM_009170246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPJ0"/>
    <dbReference type="GeneID" id="20319453"/>
    <dbReference type="KEGG" id="ovi:T265_05271"/>
    <dbReference type="CTD" id="20319453"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705490" evidence="2">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11311" checksum="07256DAE8D8D415A" modified="2014-10-01" version="1" fragment="single">CQKGFGHLSLLKLILLTAPREIGPKGIRHFTDDTPYLLPYYSHGLPNTLWGLRQTAPGVRQTSCLLRTHERRHPSYRSWSTPNKLSTQDARKTSPSLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQC9</accession>
    <name>A0A074ZQC9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_04046</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166945.1">
        <property type="nucleotide sequence ID" value="XM_009168681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQC9"/>
    <dbReference type="STRING" id="6198.A0A074ZQC9"/>
    <dbReference type="GeneID" id="20318232"/>
    <dbReference type="KEGG" id="ovi:T265_04046"/>
    <dbReference type="CTD" id="20318232"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="72"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="271"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER29301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="473" mass="52521" checksum="8AF433D0B1266A99" modified="2014-10-01" version="1">MFEVSQSNILLKEISQTRDRAGFQRECISIHVGQAGVQIGNACWELYCLEHGILPDGQMPDGTGVGPHDGYHDSFFSQSGSGKQVPRAVFIDLEPTVIDEVRTGTYRQLFHPEQMITGKEDAANNYARGRYTIGREFIDAVTDRVRKMTNQCDGLQGFFVFHSFGGGTGSGFTSLLMEKLNAEYGKKSKLEFAVYPAPTISTSVVEPYNSILTTHTTLEHSNCSFMVDNEAIYDICKSKLNISSPSYINLNRLIAQVVSSVTASLRFGGSLNVDLNEFQTNLVPYPRIHFPLATYAPIISADKARHEQLSVSEITHACFDPSSQMVKCDPRSGKYIACCLLYRGDVVSKDAIDTISVIKNKGAVQFVDWAPAGFKLGVNSQPPTAVPGGDLAQVKRAVCMLSNLTAIREPWHRLNYKFDLMFAKRAFVHWYVGEGMEEGEFVEAREDLAALEKDYEEIAMDEDLDDEEAADTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQD7</accession>
    <name>A0A074ZQD7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170689.1">
        <property type="nucleotide sequence ID" value="XM_009172425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQD7"/>
    <dbReference type="GeneID" id="20321183"/>
    <dbReference type="KEGG" id="ovi:T265_07004"/>
    <dbReference type="CTD" id="20321183"/>
    <dbReference type="OrthoDB" id="10629901at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="221" mass="25251" checksum="9D96532FB579D04E" modified="2014-10-01" version="1">MYKQDHFLRIIELDQYTPVDAPVNRSMSYKEDINENPGPEKKSPGIHYIKEKTAVRHDPPDHLLPNGYHHLMFGPDQFSFFVPAVDTGPMSASYRAFICILLASVMLCSTSNAHGRAYGESPEEEFPDDFEFSDDTRPSMGPCLPLTEPSFASFLRQLCYARRPMHMEEHMAKALRKNSLTILNSLTILVPQWFDDRFIQGAKETFLRNFVVIPPTPPSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS13</accession>
    <name>A0A074ZS13_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166055.1">
        <property type="nucleotide sequence ID" value="XM_009167791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS13"/>
    <dbReference type="GeneID" id="20317517"/>
    <dbReference type="KEGG" id="ovi:T265_03330"/>
    <dbReference type="CTD" id="20317517"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20452" checksum="5DD082019E593446" modified="2014-10-01" version="1">MKKSTCAQSDASPRSQSAQHVSDSRKLLTRLLKTLRQPSAGFALLGAHQVGAVPEFPSILCSNFLGSMFLWDLNTYLTRYRITGGPSAYDLIIIITIIIIIMIMIIIIIDSMISVFNTDASLPYNRDLSEILIVKKRIKWMGEGLSASLTQSFRGHGVGPSLFTPLRIGHGKQYSLRQTMVRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSR1</accession>
    <name>A0A074ZSR1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603913">
        <property type="protein sequence ID" value="KER18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177949.1">
        <property type="nucleotide sequence ID" value="XM_009179685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSR1"/>
    <dbReference type="GeneID" id="20326485"/>
    <dbReference type="KEGG" id="ovi:T265_12317"/>
    <dbReference type="CTD" id="20326485"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="9767" checksum="A51ADC83AE9AAE75" modified="2014-10-01" version="1">MKCAVSSCRLKDFCPSTTIKHIQSLQPQTIFGVRSIVNETSPFSQRDSLRGMGPLAPSQFSDTQAPSITVISNPLQVDLMPACSPDGNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSW6</accession>
    <name>A0A074ZSW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165795.1">
        <property type="nucleotide sequence ID" value="XM_009167531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSW6"/>
    <dbReference type="GeneID" id="20317313"/>
    <dbReference type="KEGG" id="ovi:T265_03126"/>
    <dbReference type="CTD" id="20317313"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11484" checksum="002299E129906FEF" modified="2014-10-01" version="1" fragment="single">WTRNTAPKKGRVLAQVPAQVLVQVMEGTNEVVLRNTSDTVQKNANMEIRRATIRRNIYPLMSYSSKGVASKLLMTWRQACVPTGKQEQMVMATMHHEIGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSX2</accession>
    <name>A0A074ZSX2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lanthionine synthetase C-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169778.1">
        <property type="nucleotide sequence ID" value="XM_009171514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSX2"/>
    <dbReference type="GeneID" id="20328152"/>
    <dbReference type="KEGG" id="ovi:T265_13985"/>
    <dbReference type="CTD" id="20328152"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47325" checksum="6388AC39B3316D05" modified="2014-10-01" version="1">MSARCFQNPYNDVTDPRQPLVISPEFSMQQALECIQTCFKNCPPSPRTFDGCLYTGYIGIAWAALDITRHANVPSTARSVLLGNAKQLVEAALRSVQEQSNARRMNKEDCLSILLGQPGIWIAAVMLYQQLNDMEQRNRFLEAYVNLAPHFQPAVIFQQGSDEYFIGRAGYLAGLAVLRSYTGEQFIADSTIHSICDAILQSGVNYARAHRSPCPLMYAYYGTEYLGAGHGMIGILFALMLFPSYLRSNPAADQAVQQTLLYLISITSPQTGNLPCAMDEVGPQRQRPDSDILVHWCHGATGAIMAYARAYLLWKDERYLAECRRCAETVWQRGLLKKGPGICHGVAGSGYALLLMFRLTGELVYLHRAAMFATFMQSDTFRQARRPDCPHSLFEGLAGTACFFADLADPCKSGFPFMNPLWDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW8</accession>
    <name>A0A074ZTW8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169386.1">
        <property type="nucleotide sequence ID" value="XM_009171122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW8"/>
    <dbReference type="GeneID" id="20320152"/>
    <dbReference type="KEGG" id="ovi:T265_05970"/>
    <dbReference type="CTD" id="20320152"/>
    <dbReference type="OrthoDB" id="6248102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="603" mass="68111" checksum="7183A2449652B0A3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTZ3</accession>
    <name>A0A074ZTZ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">T265_04040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166939.1">
        <property type="nucleotide sequence ID" value="XM_009168675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTZ3"/>
    <dbReference type="STRING" id="6198.A0A074ZTZ3"/>
    <dbReference type="GeneID" id="20318226"/>
    <dbReference type="KEGG" id="ovi:T265_04040"/>
    <dbReference type="CTD" id="20318226"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="46342" checksum="45C8C38A225752F8" modified="2014-10-01" version="1">MDPGGALKISRLFKVHYGGDGVDFVDQLNYQFTSGMIIVFIVMIGFRQYVGKPLHCWVPQEFTSSWEDYAENLCWVQNTYFLLPNEAIPEEDFEMLRVRHISYYQWVAIVLAGQAMMAWVPQMFWRVWSKRVPVLLRNAREAAVPDKETRHKAISCLVAALEEVSEASKRFRRTRGVFKRCLRGAPPTTQITLLFLFVRFLFIANNVGQIYIMRRFIGTNDTLFGLHVFQELMTGSQWEVSGLFPRVTYCDVKVRKLGQLKPASYTLQCVLPVNYFIEKVYVFLWFWFIIVAGITALNTLQWIFNVCVPFRRVYFVRQYLKALKQLSHTEETECARFVNNDLGCDGVFLLQAVSRISSDLIVLDVTGMLWTNYQRAKITGTEGDITRFIESINRVGGVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUH6</accession>
    <name>A0A074ZUH6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165536.1">
        <property type="nucleotide sequence ID" value="XM_009167272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUH6"/>
    <dbReference type="STRING" id="6198.A0A074ZUH6"/>
    <dbReference type="GeneID" id="20327287"/>
    <dbReference type="KEGG" id="ovi:T265_13119"/>
    <dbReference type="CTD" id="20327287"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19867">
        <property type="entry name" value="DSRM_DGCR8_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="302" mass="33507" checksum="10492B18CDC067EE" modified="2014-10-01" version="1" fragment="single">LEGVINLTGKSFVCILHEYCQTVIRSPPTYQTVVLENEKNPYKLTVLIGGTPYATGVGRSKKQARLEAARNALSRLIPDFDKIVGSHNPTNGPTVASERDLQLFDGVSITDPRLYEMSVRMAFPTPHNCLVECLSRNCVPESDLKANMMSQGRSKHFFTLQLREHSIKVPCRNKREGRHLAAQHLLARLHPEITSWGGILRIYGPGTKPDKRGELETIQGAQNQEKSAVKTSLIRLLKTKMRELADQWEKGGQNIHHKGKFIVSADNLPVVTFHPDSQTDIYGSVPAPSSPSPPTLSPSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV69</accession>
    <name>A0A074ZV69_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168992.1">
        <property type="nucleotide sequence ID" value="XM_009170728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV69"/>
    <dbReference type="GeneID" id="20319845"/>
    <dbReference type="KEGG" id="ovi:T265_05663"/>
    <dbReference type="CTD" id="20319845"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25668" checksum="D65FF438A86728D5" modified="2014-10-01" version="1">MFQHKVTKGGKPSIQSVPEEWISKEFYQEKLEEEDISTTATARTSHQTGSPTLHQEYIRTRTQIIGAKRNFVAHKPSATLRKLISRPKDNRDKTKRNNVIYQIDCNKFYVGQTGRKLCTRIKEHNAAVRRHDPLSLISIHEDQEGHKFNLENAKILAYGDTRHGREFLEAWYSTAGSINRCIELDPIYAPLRARDQHRNRNTQGGPNNGLTNEETRNSSESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVY5</accession>
    <name>A0A074ZVY5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168692.1">
        <property type="nucleotide sequence ID" value="XM_009170428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVY5"/>
    <dbReference type="GeneID" id="20319603"/>
    <dbReference type="KEGG" id="ovi:T265_05421"/>
    <dbReference type="CTD" id="20319603"/>
    <dbReference type="OrthoDB" id="10608896at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="189" mass="21368" checksum="D169C5CD6B8C1705" modified="2014-10-01" version="1">MNNSALLFRLGSGIHGLIHRIEAFAQVSRVGFLLVVQRLLFTREAQMKKGCSTALYVLSAEQLTEAREYCDRLLSPTKDEACGGLKKSLLKPYEWCVTPYNISLLAILGLPTAANRASEMIPCICLYFLPSNSKRCVVRMIKTLLIAVFIILLFQYSKANTYTLIGTRTCYFLRFADFGFLVRFAILIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW75</accession>
    <name>A0A074ZW75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009166350.1"/>
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    <dbReference type="STRING" id="6198.A0A074ZW75"/>
    <dbReference type="GeneID" id="20316364"/>
    <dbReference type="KEGG" id="ovi:T265_02176"/>
    <dbReference type="CTD" id="20316364"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19216" checksum="AD7D773A01540BE5" modified="2014-10-01" version="1">MEVGVLSSSHLVQKSKHSKTTREKNKTASAIHLELSKTQKDDLLEAFNMLDAEGTGLIGIREISVALRALGFDPSASELRQMMLLYDKENKGVLEFKSFLELMTKKMTERDPNEDLVKAFRIMDKDNTGTINFDDLKRAAKLLGEDMNDEEIQVNRVYPEPVVPPKSGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWG8</accession>
    <name>A0A074ZWG8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009166182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWG8"/>
    <dbReference type="STRING" id="6198.A0A074ZWG8"/>
    <dbReference type="GeneID" id="20316222"/>
    <dbReference type="KEGG" id="ovi:T265_02034"/>
    <dbReference type="CTD" id="20316222"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="35757" checksum="9D7349CC79738B40" modified="2014-10-01" version="1">MEVIRKNVNSLSEQLLRNKKTSSRPLSLLPENVGVMVVSKVVPSKKLLRVQLPHCVPDLSVCFLVKDTDKTDYNKSVDAWKLRWKTDSMKRHLSTPSMPTFIPLRELKLAYQPFASKQRLAATFDLFLADRRIVHHLPSKLGKAFYGCGRGKIPVPVTLTNCNVVDVLEKERSTILFQIRGLGSTECVPVGDLRLSLSQLKDNILTVCKRICKDWPGGGLCNVRSIYIQCPGGNIPLYFDATELPLETIVAESSQLVKTRELNPPGKQPTKQLTMDLLSRVAEDLPLPTGGLEEIVAKAKKARKLKRLGQTGKVRKPRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX69</accession>
    <name>A0A074ZX69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165667.1">
        <property type="nucleotide sequence ID" value="XM_009167403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX69"/>
    <dbReference type="GeneID" id="20317201"/>
    <dbReference type="KEGG" id="ovi:T265_03013"/>
    <dbReference type="CTD" id="20317201"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8198" checksum="CD7EA27A76BA17D3" modified="2014-10-01" version="1">MRFPGVKCAANECDGNGENPRDTQIVTVKNSMCEAPVNKVHTRIHNVAIALERQQYHGHKEQKETIVKELADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYG3</accession>
    <name>A0A074ZYG3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163673.1">
        <property type="nucleotide sequence ID" value="XM_009165409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYG3"/>
    <dbReference type="STRING" id="6198.A0A074ZYG3"/>
    <dbReference type="GeneID" id="20315571"/>
    <dbReference type="KEGG" id="ovi:T265_01383"/>
    <dbReference type="CTD" id="20315571"/>
    <dbReference type="OrthoDB" id="6287768at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705564" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="30"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="323"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="740" mass="82353" checksum="15481BDEF4DE5AFD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYL6</accession>
    <name>A0A074ZYL6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175987.1">
        <property type="nucleotide sequence ID" value="XM_009177723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYL6"/>
    <dbReference type="GeneID" id="20325310"/>
    <dbReference type="KEGG" id="ovi:T265_11142"/>
    <dbReference type="CTD" id="20325310"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8287" checksum="6F106E8F8D1346F4" modified="2014-10-01" version="1">MIPDEVDAINPDERRRVPVLMSLVEGALTLEGNSDKHEYSRRATVIPGRKSFNTILHEEETGAFPVKPTGARTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYW0</accession>
    <name>A0A074ZYW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164011.1">
        <property type="nucleotide sequence ID" value="XM_009165747.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYW0"/>
    <dbReference type="GeneID" id="20315869"/>
    <dbReference type="KEGG" id="ovi:T265_01681"/>
    <dbReference type="CTD" id="20315869"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="391" mass="44380" checksum="DD91F64CFF15BEC8" modified="2014-10-01" version="1">MRAEILPDCLSLDRSSPYAEFGLEPRVFRSLNSHFKHHHLELLPRWPCLAAMPPERSTRAEILPGCPIVHGGSRDEEFLFEPRTFRLVNSRFPHGHFTPQAACLTAMLHEGWDIARLSEPRQGESNGIARVRATSLPAQSPSFHQPYVLLEPRWSRWLEREFTDREVHGSNPTSTRLPLSRLGQPGSIPALMLPSGGMAARHRKGATAERFLSFFLLEPKLDCFREIYSFVPLKLVIRSIRTNTAYRRQEGSLDTLMRINLVLMGHSTESLVCEVPQLNAPHNHRVAVAHFWCLAAMPHEGSTRVGILPGRPSLDREEGRETEXRVKQVEIESKYNCSAVAHFWCLAAMPHEGSTRVGILPGRPSLDRRGRETEIKLEPRTFRSVNSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0X8</accession>
    <name>A0A075A0X8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Apoptosis inhibitory protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164397.1">
        <property type="nucleotide sequence ID" value="XM_009166133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0X8"/>
    <dbReference type="STRING" id="6198.A0A075A0X8"/>
    <dbReference type="GeneID" id="20316183"/>
    <dbReference type="KEGG" id="ovi:T265_01995"/>
    <dbReference type="CTD" id="20316183"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61355" checksum="2C5AD95A976A9FB5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A118</accession>
    <name>A0A075A118_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162896.1">
        <property type="nucleotide sequence ID" value="XM_009164632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A118"/>
    <dbReference type="GeneID" id="20326791"/>
    <dbReference type="KEGG" id="ovi:T265_12623"/>
    <dbReference type="CTD" id="20326791"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14152" checksum="98589AB42C2D9B4F" modified="2014-10-01" version="1" fragment="single">MDDLASLNTTNLSTVSDQFPYDYAFAVVYLFVQTPLCTFGMILNVLNICVFSQPAFSAPAYIMMKFLSLADAITLGVRIPQGLILFQLYGEAMAVNLLSPDTTGSDLCSNSFATFHFIYASQLWSYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F0</accession>
    <name>A0A075A1F0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_12601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162786.1">
        <property type="nucleotide sequence ID" value="XM_009164522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F0"/>
    <dbReference type="STRING" id="6198.A0A075A1F0"/>
    <dbReference type="GeneID" id="20326769"/>
    <dbReference type="KEGG" id="ovi:T265_12601"/>
    <dbReference type="CTD" id="20326769"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="134"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="465"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="167"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="515"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="611" mass="69473" checksum="84C5C8B57759D965" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2D7</accession>
    <name>A0A075A2D7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162340.1">
        <property type="nucleotide sequence ID" value="XM_009164076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2D7"/>
    <dbReference type="STRING" id="6198.A0A075A2D7"/>
    <dbReference type="GeneID" id="20314519"/>
    <dbReference type="KEGG" id="ovi:T265_00331"/>
    <dbReference type="CTD" id="20314519"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="380" mass="41600" checksum="6A001BDCCFEE6C2D" modified="2014-10-01" version="1">MSTQGTGVVEDFGVTSDGQRVQLVTIKTENLSGINRPACLKVCTFGAAIVSCCVPGRNSDGALDMFDVVLGYRDAESYETNPPYLGVIVGRVAGRIENAQFTIPGTDKVVRLTSNSDDRHCVHGGRKGLSRVLWDISELTGQSITLTHISPNDADGFPGTMRIEVKYTFCRVVQTVELRIEYHASLVPVPQTACPINLTNHTLWNLAGHSSGPSCLAKHEVFIDAEKYVELEPVELIPTGRLISVEKGTPQDLRNFRPVFSGINTLGDRNNPGYDLYYVFNETTINKPRAAVFYAPSGIRLRVHTDQPGAQFYTGHYLDPKIDPVGKHGLPYEASSGLALEVQGWPNACNQPNFPARFLHSGGPAYTQNTTYILDVCDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2P0</accession>
    <name>A0A075A2P0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163685.1">
        <property type="nucleotide sequence ID" value="XM_009165421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2P0"/>
    <dbReference type="GeneID" id="20315583"/>
    <dbReference type="KEGG" id="ovi:T265_01395"/>
    <dbReference type="CTD" id="20315583"/>
    <dbReference type="OrthoDB" id="10029313at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14985" checksum="9708A10E72E14FCA" modified="2014-10-01" version="1">MSTYLQIKGGLVVVRSVVLRVSLPGTATYKLAKDLWRRLKHLISGSEHTIKNAGQFLRKLRSFSIEDYEVMLSPDVTSHFTSINHNLARVTIAELLRNNSNTTEAMKREIYANCWTSARIHTLASMDKHINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Y0</accession>
    <name>A0A075A2Y0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163562.1">
        <property type="nucleotide sequence ID" value="XM_009165298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Y0"/>
    <dbReference type="GeneID" id="20315480"/>
    <dbReference type="KEGG" id="ovi:T265_01292"/>
    <dbReference type="CTD" id="20315480"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13321" checksum="17158069EA4CF248" modified="2014-10-01" version="1">MLLAHVPTGIRKKTWKTSGGKADDEKQLSKYAAIVYNLQPIFNMVIRRHDLDLNLTGFAVCYASYSIQVVTCSNETQTPRVRRTRNNVSDDASETFKKAHAFLLLQNTNTSWLDFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A375</accession>
    <name>A0A075A375_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163625.1">
        <property type="nucleotide sequence ID" value="XM_009165361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A375"/>
    <dbReference type="GeneID" id="20315543"/>
    <dbReference type="KEGG" id="ovi:T265_01355"/>
    <dbReference type="CTD" id="20315543"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19849" checksum="9D453D7D70D8D9C6" modified="2014-10-01" version="1">MARSNGQFSEEYKSLMVYGGHVQTDQLKQIGQQTAGVHTLDILPIDICCTCETRIWDPNLENEFLAPTHPRRYRLRTSKLTLVRLPSILYLQRLLIQKPTAVSTKRNTLLTKNSPPTCLIAALAGECTSQVDCLSLHLGDIYISKAKGCYNCGRILERCTDNQLFLRNTEFRCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3F0</accession>
    <name>A0A075A3F0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_00343</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162352.1">
        <property type="nucleotide sequence ID" value="XM_009164088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3F0"/>
    <dbReference type="STRING" id="6198.A0A075A3F0"/>
    <dbReference type="GeneID" id="20314531"/>
    <dbReference type="KEGG" id="ovi:T265_00343"/>
    <dbReference type="CTD" id="20314531"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000053">
        <property type="entry name" value="potassium voltage-gated channel subfamily A member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="526" mass="60206" checksum="32D1DD7B7F72DA62" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3M8</accession>
    <name>A0A075A3M8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162044.1">
        <property type="nucleotide sequence ID" value="XM_009163780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3M8"/>
    <dbReference type="GeneID" id="20314311"/>
    <dbReference type="KEGG" id="ovi:T265_00123"/>
    <dbReference type="CTD" id="20314311"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="29260" checksum="0CDD97F7B9012A9E" modified="2014-10-01" version="1">MLPDRKPDKALYRPPPLRTSTDSPRQSVMKSDEIRNISCKEPSRKASGDAESIQTLLKALSISGGSQDQEDVTNKHGGTVTNGRSPVITPAKGSREPAIDYKNFGHVLELYNFRKELSSADLQAELAGFEDSGFYLKWVDDTHCLAVFSSKSEADRALSQISGLLVEARQFKDASLESKLKLAKSPGDWAMPYKKRPPTSSSTAHRLILGHLSLRSTNPKSPQELEKEKRDKEALQEARAQHERRKKAEKAIWDDERWDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5I1</accession>
    <name>A0A075A5I1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162756.1">
        <property type="nucleotide sequence ID" value="XM_009164492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5I1"/>
    <dbReference type="STRING" id="6198.A0A075A5I1"/>
    <dbReference type="GeneID" id="20314852"/>
    <dbReference type="KEGG" id="ovi:T265_00664"/>
    <dbReference type="CTD" id="20314852"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704512" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="227"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="522" mass="59169" checksum="96F967DAF8CBE876" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5U1</accession>
    <name>A0A075A5U1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_02677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165243.1">
        <property type="nucleotide sequence ID" value="XM_009166979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5U1"/>
    <dbReference type="STRING" id="6198.A0A075A5U1"/>
    <dbReference type="GeneID" id="20316865"/>
    <dbReference type="KEGG" id="ovi:T265_02677"/>
    <dbReference type="CTD" id="20316865"/>
    <dbReference type="OrthoDB" id="10258956at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="31537" checksum="75E47D794086E656" modified="2014-10-01" version="1">MDANDLHLNIDYVGSCGVVLTPEQKATLQTSLTILRHENNFTNVLFWGIIRGVSGDYFIAQGIGKDAITDRKTLYSKDCLVWGLLPVPGKSDIEKSKYFKGRFTGDPSYECEFVDIRQRPGEEGDEIEERENLITMKEEDRLAATIERIERDVSIIPRGAYMRLSSGQVIRNKNFEGLTVAEAAKLLSYFHFRPPIQLPHKPLLDRARLDKAIDFLDTIEDDNPKGCWSITLERGGRLVLVKSLLWLGYVLYHLPGTNKYGSIYVGTGEYNVDLPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A698</accession>
    <name>A0A075A698_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162322.1">
        <property type="nucleotide sequence ID" value="XM_009164058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A698"/>
    <dbReference type="GeneID" id="20314501"/>
    <dbReference type="KEGG" id="ovi:T265_00313"/>
    <dbReference type="CTD" id="20314501"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104565" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="32"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="11">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="645" mass="73547" checksum="8B56C474A083BECA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6N3</accession>
    <name>A0A075A6N3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162191.1">
        <property type="nucleotide sequence ID" value="XM_009163927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6N3"/>
    <dbReference type="STRING" id="6198.A0A075A6N3"/>
    <dbReference type="GeneID" id="20314407"/>
    <dbReference type="KEGG" id="ovi:T265_00219"/>
    <dbReference type="CTD" id="20314407"/>
    <dbReference type="OrthoDB" id="6285467at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21580" checksum="5E84B843D1C8A384" modified="2014-10-01" version="1">MKTRPPARNHEVVESLPVGSASAIQPTVPGNRETLEFPRDHCLMLFGSKESGEEGAQARYNHDLNLLQVLLQVDKLADADEPGIRVRRILRLGKRVAGIHRPLKIVFENADAPKRLLSRAWGLKGIDIYIRSDVDPSQRAQLKAAVVGLRRRTLEGENDLRIVNFRIVKWRAFINRPVTLTARSQSHSLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7B1</accession>
    <name>A0A075A7B1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164704.1">
        <property type="nucleotide sequence ID" value="XM_009166440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7B1"/>
    <dbReference type="GeneID" id="20327119"/>
    <dbReference type="KEGG" id="ovi:T265_12951"/>
    <dbReference type="CTD" id="20327119"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="332" mass="37626" checksum="E436142468C813A4" modified="2014-10-01" version="1" fragment="single">GGGSAIDRHPFLSTYVDLCHALVTLCLSFRIPEVRKIRATRLIREKLSDDRQLCRSMYLLELRSSDEGSHRNAPYISSSNPSDKIYPSKHLVYLAHASDTYLLFQEEQKAQILLVILTRIIQAFGLCFEPTNCSVMLRNLKFRSPHSLLVSTLGFCGIGGGGSAIDRHPFLSTYVDLCHALVTLCLSFRIPEVRKIRATRLIREKLSDDRQLCRSMYLLELRSSDEGSHRNAPYISMQVPQNPGDEIYPSKHLVYLVHASDTYLLFQEEQKAQILLVILTRIIQAFGLCFEPTNCSVMLRNVRYLIVPLGKWGLTPEAFEHSTCIGSCVSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7U4</accession>
    <name>A0A075A7U4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164523.1">
        <property type="nucleotide sequence ID" value="XM_009166259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7U4"/>
    <dbReference type="GeneID" id="20316288"/>
    <dbReference type="KEGG" id="ovi:T265_02100"/>
    <dbReference type="CTD" id="20316288"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="205" mass="21903" checksum="E5630F25C18DC5E1" modified="2014-10-01" version="1">MGKSSRSPEEERIPANNVAAAAAAAAFVSVPVVGEEDSSPSRVQLPSDLGTVSFRESQSTGAAEGGLSRPGSGVLATENRLRVNDLGRVVILLGSYKRQYGETSNELNEGRELPERGNKEENGPANLGDEPKEDFVVGFLESDGVSEVARGFLPIVADEVDASDWERLTKVSEDGESVEPFCCNPGVESDENPVEHRAGKWNRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8F4</accession>
    <name>A0A075A8F4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164166.1">
        <property type="nucleotide sequence ID" value="XM_009165902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8F4"/>
    <dbReference type="GeneID" id="20315980"/>
    <dbReference type="KEGG" id="ovi:T265_01792"/>
    <dbReference type="CTD" id="20315980"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8637" checksum="7362DAE507DC3919" modified="2014-10-01" version="1">MTSIHTDRPPQPFVDHNRCGRNGCPSNVKRSMQCHACKSWWHFKCTGERQPLTDKNKTDPGNLGKSLDPVYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A914</accession>
    <name>A0A075A914_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596826">
        <property type="protein sequence ID" value="KER24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172230.1">
        <property type="nucleotide sequence ID" value="XM_009173966.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A914"/>
    <dbReference type="GeneID" id="20322402"/>
    <dbReference type="KEGG" id="ovi:T265_08223"/>
    <dbReference type="CTD" id="20322402"/>
    <dbReference type="OrthoDB" id="6255127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1798" mass="195619" checksum="FEAF4B4046E4C27B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9B6</accession>
    <name>A0A075A9B6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trematode Eggshell Synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163877.1">
        <property type="nucleotide sequence ID" value="XM_009165613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9B6"/>
    <dbReference type="GeneID" id="20315742"/>
    <dbReference type="KEGG" id="ovi:T265_01554"/>
    <dbReference type="CTD" id="20315742"/>
    <dbReference type="OrthoDB" id="6269925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012615">
        <property type="entry name" value="TES"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08034">
        <property type="entry name" value="TES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705640" description="Trematode Eggshell Synthesis" evidence="2">
        <location>
            <begin position="17"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="69962" checksum="B0ADCE509DB8191E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACV7</accession>
    <name>A0A075ACV7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009164052.1"/>
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    <dbReference type="STRING" id="6198.A0A075ACV7"/>
    <dbReference type="GeneID" id="20314495"/>
    <dbReference type="KEGG" id="ovi:T265_00307"/>
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    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15553">
        <property type="entry name" value="PHD_Cfp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="10">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="84957" checksum="65D14625F8ECF9EC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF38</accession>
    <name>A0A075AF38_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168898.1">
        <property type="nucleotide sequence ID" value="XM_009170634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF38"/>
    <dbReference type="GeneID" id="20319764"/>
    <dbReference type="KEGG" id="ovi:T265_05582"/>
    <dbReference type="CTD" id="20319764"/>
    <dbReference type="OrthoDB" id="6256565at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57086" checksum="06D7361F3DCD8442" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFP6</accession>
    <name>A0A075AFP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclin-A/CDK2-associated protein p19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p19skp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_05109</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168290.1">
        <property type="nucleotide sequence ID" value="XM_009170026.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AFP6"/>
    <dbReference type="GeneID" id="20319291"/>
    <dbReference type="KEGG" id="ovi:T265_05109"/>
    <dbReference type="CTD" id="20319291"/>
    <dbReference type="OrthoDB" id="10068803at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000270">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1561"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="15">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="15">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="14">
        <location>
            <begin position="537"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1337"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1699" mass="192469" checksum="F5986C7224926AEC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG27</accession>
    <name>A0A075AG27_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167922.1">
        <property type="nucleotide sequence ID" value="XM_009169658.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AG27"/>
    <dbReference type="GeneID" id="20327769"/>
    <dbReference type="KEGG" id="ovi:T265_13602"/>
    <dbReference type="CTD" id="20327769"/>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="2">
        <location>
            <begin position="246"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2308" mass="260368" checksum="AD6FC41941A51E85" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH03</accession>
    <name>A0A075AH03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166998.1">
        <property type="nucleotide sequence ID" value="XM_009168734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH03"/>
    <dbReference type="STRING" id="6198.A0A075AH03"/>
    <dbReference type="GeneID" id="20318274"/>
    <dbReference type="KEGG" id="ovi:T265_04088"/>
    <dbReference type="CTD" id="20318274"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="13"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="488" mass="52860" checksum="191E5963AC34A195" modified="2014-10-01" version="1">MVISGYVAERINLRHFLAFGMLFSGLTNIAFGFAYYCGIHNYLYFFCVQVLSGVTQASGWPAVVTLMGNWWGKTSGYVAERINLRHFLAFGMLFSGLTNIAFGFAYYCGIHNYLYFFCVQVLSGVTQASGWPAVVTLMGNWWGKTRRGFIMGLWNAHTSVGNILGSLVAGYFADSDWGAAFAVPGIMMAVGGLVVYCTLIDRPERLQLPGRFTRPPHLSLPNLKSAVESSCLPRRPSSDRLEELPCQSNSTTTTKQAIGLCDALRIPNVLAYSLLLFFAKLVSYTFLYWLPNYLVVVEPGTVTAEQAAQLSVLFDLGGIVGGILAGWLSDPKESDSDAMTIWRRAFMCSVMLSLAAPLLIAYQALASAVSTTSLVLLFCCGLTVNGPYALITTAVSADLGTQHALQGRARALATITAIIDGTGSLGAALGPFLTGILVPFGWSAVFLMLLTSDLLALATSLWIVCRSSRSTVKPSFVDARIKYTTLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJN4</accession>
    <name>A0A075AJN4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162639.1">
        <property type="nucleotide sequence ID" value="XM_009164375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJN4"/>
    <dbReference type="STRING" id="6198.A0A075AJN4"/>
    <dbReference type="GeneID" id="20314759"/>
    <dbReference type="KEGG" id="ovi:T265_00571"/>
    <dbReference type="CTD" id="20314759"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41934" checksum="241CC45609F912B4" modified="2014-10-01" version="1">MAEDEINALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQPGIMIGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKIMTERGHSFTTTAEREIVRDIKEKLCYVALDFDHEMATASESSSLEKSYELPDGQVITIGNERFRCPEAMFQPSFLGMECAGLHETAYTSIMKCDVDIRKDLYANIVLSGGSTMFPGIADRMQKEITLLTPSTMKIKIIAPPERKYSVWIGGSILASLSTFHQMWITKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTC5</accession>
    <name>A0A074YTC5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_16334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL614836">
        <property type="protein sequence ID" value="KER18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178207.1">
        <property type="nucleotide sequence ID" value="XM_009179943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTC5"/>
    <dbReference type="STRING" id="6198.A0A074YTC5"/>
    <dbReference type="GeneID" id="20330499"/>
    <dbReference type="KEGG" id="ovi:T265_16334"/>
    <dbReference type="CTD" id="20330499"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="9099" checksum="042DAD66B6350F06" modified="2014-10-01" version="1" fragment="single">CERLGYPFVNRIEPSDLRYYINLIKEKDYAVDHHHLKKYFPLRAVKAGVLRLYQHLLGLTFARINTTDVWHPDVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUV1</accession>
    <name>A0A074YUV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599901">
        <property type="protein sequence ID" value="KER18556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177697.1">
        <property type="nucleotide sequence ID" value="XM_009179433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUV1"/>
    <dbReference type="GeneID" id="20330146"/>
    <dbReference type="KEGG" id="ovi:T265_15981"/>
    <dbReference type="CTD" id="20330146"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7294" checksum="9EEC83F176F105F4" modified="2014-10-01" version="1" fragment="single">CHASIYPEDNSGAKTVISGAVSHPHSKVPQSQMKEVLNRIGERQPPNDRLLAVNGTVIPSTNVSTCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUW1</accession>
    <name>A0A074YUW1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER18566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177687.1">
        <property type="nucleotide sequence ID" value="XM_009179423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUW1"/>
    <dbReference type="GeneID" id="20326396"/>
    <dbReference type="KEGG" id="ovi:T265_12228"/>
    <dbReference type="CTD" id="20326396"/>
    <dbReference type="OrthoDB" id="6251461at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="290" mass="32956" checksum="E9B7291AF14C076D" modified="2014-10-01" version="1">MTRPSKPKLVLLGDANPNSSANNDFVQPPSIFHFYPDVEITLYCSTPRYQLFCERADQIANGVRIIRTAFRAILHLNRDKESSHEVVLPHTMRTTPPMRHLNSTDPDKLHYAWRFRLRREYSGAYVTCEVQPELIPPILVPAAYWDWLSSEFSPHRIQQMISVSDPIALHLYIESGYIQIIPEPTRHAGDPEISSVVLQPTQTLSCQTNIATENGPNLTIYPILNNKIELAVRSDLSASSMWLDKGRATPDWARISHTKLVRLYVPADPKVFGTYLIYCAVPGTKFSRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVJ4</accession>
    <name>A0A074YVJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597942">
        <property type="protein sequence ID" value="KER18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177462.1">
        <property type="nucleotide sequence ID" value="XM_009179198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVJ4"/>
    <dbReference type="GeneID" id="20329988"/>
    <dbReference type="KEGG" id="ovi:T265_15823"/>
    <dbReference type="CTD" id="20329988"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11806" checksum="7542B3F4F6871B6C" modified="2014-10-01" version="1" fragment="single">MPLKLKAVPGTASDVYQNILRFAAEYIKYIFLNIHEWENILEATWVYRLELTEDNEVIAHGHADLNVYYLLRKHKSLEWNNIIEEFNSNFMDKFPFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWV5</accession>
    <name>A0A074YWV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597259">
        <property type="protein sequence ID" value="KER19281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176971.1">
        <property type="nucleotide sequence ID" value="XM_009178707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWV5"/>
    <dbReference type="STRING" id="6198.A0A074YWV5"/>
    <dbReference type="GeneID" id="20326058"/>
    <dbReference type="KEGG" id="ovi:T265_11890"/>
    <dbReference type="CTD" id="20326058"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12343">
        <property type="entry name" value="RRM1_2_CoAA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="700" mass="77728" checksum="5836C608F68B66D1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX98</accession>
    <name>A0A074YX98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597212">
        <property type="protein sequence ID" value="KER19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176824.1">
        <property type="nucleotide sequence ID" value="XM_009178560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX98"/>
    <dbReference type="GeneID" id="20325966"/>
    <dbReference type="KEGG" id="ovi:T265_11798"/>
    <dbReference type="CTD" id="20325966"/>
    <dbReference type="OrthoDB" id="6239126at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="328"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="510" mass="59395" checksum="AE8862A51737F386" modified="2014-10-01" version="1">MVTDLADFAAKRSAEKSPVSGGNPPSPTLSFEQWVDHQNHQPPSPDLFSDAAVDEEFWTSHQYNPAEADTIPVVQTPPTQYRPSPLDLSNVWHSKRRQLFSPEPSITDNNKLWTFVYRGQPPRFERGTRANCLYVDHGDHYHFVFECCPQNKTRTIQRLIESGNLDRRQSMSIMATVQPVINWNHFAAYLVRAAQTPIICIGKKLEHLRDDLYMVPRERKDCATLLRDDRGSKQKHNNINRKRRRELMKGLIEAYDARSYNEFYMAMSCDDRDDIYDEYGPQWKETAEHSINNYIAGMLSKQLAMRFEEILMTNYHNRQCQHPAHTLEGEHWLDQLMAANKINKQQFLTDLTLVMNKVCTRKNAFVIEGPTTTGKTLFVKLIAENYIYGTVQRSGDHSQFFLMNLLNKALALMEEPRITQLTVNDFKELLGGNPFDIHVKHQKDERLQRLPVLITTNNNLVYYVLDPDGKAILERCFYYKFLIKVGSEELPEPPCHLCTCHFRNWYFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY99</accession>
    <name>A0A074YY99_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597142">
        <property type="protein sequence ID" value="KER19766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176490.1">
        <property type="nucleotide sequence ID" value="XM_009178226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20325715"/>
    <dbReference type="KEGG" id="ovi:T265_11547"/>
    <dbReference type="CTD" id="20325715"/>
    <dbReference type="OrthoDB" id="10037631at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1407"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1490"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1519"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="8">
        <location>
            <begin position="1917"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1329"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2178"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2183"/>
            <end position="2195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2204"/>
            <end position="2216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2391" mass="268514" checksum="BEBEE159D1BDD625" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZA5</accession>
    <name>A0A074YZA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597105">
        <property type="protein sequence ID" value="KER20008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176239.1">
        <property type="nucleotide sequence ID" value="XM_009177975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZA5"/>
    <dbReference type="STRING" id="6198.A0A074YZA5"/>
    <dbReference type="GeneID" id="20325512"/>
    <dbReference type="KEGG" id="ovi:T265_11344"/>
    <dbReference type="CTD" id="20325512"/>
    <dbReference type="OrthoDB" id="6228167at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39498" checksum="3F1630DADD43B0CA" modified="2014-10-01" version="1">MVQCNKETRPVGRTLIHAAGSSRWHARQTGERQPLTNKNKIDPGYLGRMLDLAYQSAPVNEKPVKKGFAEWVVGLQACFKLGSRRSVYNRRRKVIPRITTRNEKMFCLMNVCALSLKIFLLCSRQATSDAASDAFAENLGAVSFSSFKAFEKALNEYMKNNYVVFVRSSSSRSTNAVLRYEWVYYKCNRRPPKPSESRGIRKSYTRSTGCPVRFCLRRRGNKLLVTSYYLEHNHELTKYSYDRIPVNRRLTKEEVGTCRALLNYGTPLCEVRQFVADEFGKVLTTQDLYNYRRNLTNPVACFCYSPGKVIRVDCSEANPFAPMPDTYIICCRWSRIVQLNADVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZY8</accession>
    <name>A0A074YZY8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175890.1">
        <property type="nucleotide sequence ID" value="XM_009177626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZY8"/>
    <dbReference type="GeneID" id="20325242"/>
    <dbReference type="KEGG" id="ovi:T265_11074"/>
    <dbReference type="CTD" id="20325242"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7582" checksum="78B9084F7DA4F138" modified="2014-10-01" version="1">MNTTRSRVVCIGGTDSESNMYNSVPDAGLTASNAKLLALTQLVFSAPFGLCFQIYLQLGFIDPGADDPYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0M7</accession>
    <name>A0A074Z0M7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597040">
        <property type="protein sequence ID" value="KER20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175667.1">
        <property type="nucleotide sequence ID" value="XM_009177403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0M7"/>
    <dbReference type="GeneID" id="20325063"/>
    <dbReference type="KEGG" id="ovi:T265_10895"/>
    <dbReference type="CTD" id="20325063"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12567" checksum="02A9A267AB51F64D" modified="2014-10-01" version="1">MELAGAYIVHMDAKYASLFFRVCVHTRSASDQRAQLDVRGIFRMAVVMFTALIVGVLCDGFVHTQRGTFDGVELEIGFASCPGIWDSVQFRGCDFVGECTAAAVSSDTEISVDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z234</accession>
    <name>A0A074Z234_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596993">
        <property type="protein sequence ID" value="KER21111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175138.1">
        <property type="nucleotide sequence ID" value="XM_009176874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z234"/>
    <dbReference type="GeneID" id="20324659"/>
    <dbReference type="KEGG" id="ovi:T265_10491"/>
    <dbReference type="CTD" id="20324659"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31319" checksum="6BF2D880881EB36A" modified="2014-10-01" version="1">MELQVNLDMIIRCSFLIAFLFCIDHVAWLEAIGVHNWSSIFNDNPSKTWVVLVAGTNTWNNYRYQADVFHAYQLVRKNKVPAENVITFTYDDIANNRRNPFKGKAFHDYQHKDVYNGVEIDYRGKDVTRDNFLKVLKGDKKLEANMKKVLKICMPWNLTIGSAFKKMFNKLVLYMDTSKSGSMFHDVLPSNMGIYVTTAVNETEDSFSMFCLDKKSDVCLADEYSYEWLLDSDYRPFLEVTQISNGIRLDVQQIFCSLFITSHNYSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Y9</accession>
    <name>A0A074Z2Y9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597121">
        <property type="protein sequence ID" value="KER19892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176352.1">
        <property type="nucleotide sequence ID" value="XM_009178088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Y9"/>
    <dbReference type="GeneID" id="20325600"/>
    <dbReference type="KEGG" id="ovi:T265_11432"/>
    <dbReference type="CTD" id="20325600"/>
    <dbReference type="OrthoDB" id="6266542at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="23177" checksum="371C82F31E72D981" modified="2014-10-01" version="1">MTEVDAFMRSVATRKYTSWDEFTSVLQTYMQNYHVQFVCVSSKRGNDLQLIYKLVFFRCIRHARRRSSSRGIRRVLSDDTCCPARFCVRNRDGFLTLTSYDVGHNHPLSKELYEQLSVNRHLSTSQLHQCLDVFRVENSIHAIKEYVKDHFGKLVTTKDINNYRRKLTFVLKIEPAEPSSPVLKPLVQSMLHEQAMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4I7</accession>
    <name>A0A074Z4I7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606919">
        <property type="protein sequence ID" value="KER18190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178063.1">
        <property type="nucleotide sequence ID" value="XM_009179799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4I7"/>
    <dbReference type="GeneID" id="20330399"/>
    <dbReference type="KEGG" id="ovi:T265_16234"/>
    <dbReference type="CTD" id="20330399"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8830" checksum="3B369D3578812ED4" modified="2014-10-01" version="1" fragment="single">LTVALPAYLYQKNAVKPLFRIVTPAIQTVECSLLQKFLTSMKAGCLAKSPNETTPTGFSYFDYTKQIWNEERKNALMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z676</accession>
    <name>A0A074Z676_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596891">
        <property type="protein sequence ID" value="KER22578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173682.1">
        <property type="nucleotide sequence ID" value="XM_009175418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z676"/>
    <dbReference type="GeneID" id="20323544"/>
    <dbReference type="KEGG" id="ovi:T265_09375"/>
    <dbReference type="CTD" id="20323544"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10201" checksum="2C384F14FC65C9B5" modified="2014-10-01" version="1">MKQLLCVLLGWSICSEEGENDLISIWISAYGFVASRCVGGGTAEEDHGSVIRGRDEQSSVLLCGEVSAFHYTSPTSGRSTNQRLQDSYAQDAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6F4</accession>
    <name>A0A074Z6F4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596882">
        <property type="protein sequence ID" value="KER22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173503.1">
        <property type="nucleotide sequence ID" value="XM_009175239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6F4"/>
    <dbReference type="GeneID" id="20323399"/>
    <dbReference type="KEGG" id="ovi:T265_09220"/>
    <dbReference type="CTD" id="20323399"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13178" checksum="E7AD311ED47F81EC" modified="2014-10-01" version="1">MDRCLLFKSPSLNRLDGSEMAQVVRARLEGLGNLAVSKLSSGGMAARHLKGVTAERNRPFYTESFHQADIYRKLMFVCASRLLLTRLEQPEIIPALMLHSGGKAARHRRDATAERLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Q7</accession>
    <name>A0A074Z6Q7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597477">
        <property type="protein sequence ID" value="KER18925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177328.1">
        <property type="nucleotide sequence ID" value="XM_009179064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Q7"/>
    <dbReference type="GeneID" id="20329912"/>
    <dbReference type="KEGG" id="ovi:T265_15747"/>
    <dbReference type="CTD" id="20329912"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8319" checksum="4E285D7E91F3E2AC" modified="2014-10-01" version="1" fragment="single">MERRRVGSSGHFSVALTKVVQQSAWTQHIAAARCRADQLPPILELAITNETRFVDQGYPGLMGEKGEKGDIGCYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6V2</accession>
    <name>A0A074Z6V2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173346.1">
        <property type="nucleotide sequence ID" value="XM_009175082.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z6V2"/>
    <dbReference type="GeneID" id="20328920"/>
    <dbReference type="KEGG" id="ovi:T265_14754"/>
    <dbReference type="CTD" id="20328920"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="2">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="4">
        <location>
            <begin position="826"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="166490" checksum="D6574B4E2AC6DDF2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z766</accession>
    <name>A0A074Z766_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597355">
        <property type="protein sequence ID" value="KER19060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177194.1">
        <property type="nucleotide sequence ID" value="XM_009178930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z766"/>
    <dbReference type="STRING" id="6198.A0A074Z766"/>
    <dbReference type="GeneID" id="20326198"/>
    <dbReference type="KEGG" id="ovi:T265_12030"/>
    <dbReference type="CTD" id="20326198"/>
    <dbReference type="OrthoDB" id="9977282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040057">
        <property type="entry name" value="Spe-39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364">
        <property type="entry name" value="DEFECTIVE SPERMATOGENESIS PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364:SF6">
        <property type="entry name" value="SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="32617" checksum="85E340511EAF18EA" modified="2014-10-01" version="1">MDDFSLGGMSAWPLDTFGSFASKSFLLELATRSLDGTIIVRAVGAATELGGSASADLLALPLSETIRACSWMDKSLGPGSRANELRTHHNVSDDQFHWYIVEPLVMGSRWAEMDSALLEKKWLKLRVETRLPTDRLVLYLHALNAPPQIISNYLSHSENNEELIETATRLRMYSAAIQACVRRKDRASLQELLHRIPKKRPEHAEVVYYLSTPESACEQYLLQVDLMASPVSLQNEASTDVLLLALSACIMVRSARVPKPSAHTRNVFTNISSSKDDHRCSSALSKGQKHQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z851</accession>
    <name>A0A074Z851_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172856.1">
        <property type="nucleotide sequence ID" value="XM_009174592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z851"/>
    <dbReference type="GeneID" id="20322891"/>
    <dbReference type="KEGG" id="ovi:T265_08712"/>
    <dbReference type="CTD" id="20322891"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="58" mass="6522" checksum="F405EDA08F702888" modified="2014-10-01" version="1">MSYLKPNCTKIGNTHSFKKNLAQLTTMSVGEADIATESDKLYFPLLFNSDPERQLSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z881</accession>
    <name>A0A074Z881_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_11785</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KL597206">
        <property type="protein sequence ID" value="KER19445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176809.1">
        <property type="nucleotide sequence ID" value="XM_009178545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z881"/>
    <dbReference type="STRING" id="6198.A0A074Z881"/>
    <dbReference type="GeneID" id="20325953"/>
    <dbReference type="KEGG" id="ovi:T265_11785"/>
    <dbReference type="CTD" id="20325953"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="237"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="319"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER19445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="615" mass="67649" checksum="D8DCAC22D46492BE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8G7</accession>
    <name>A0A074Z8G7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597186">
        <property type="protein sequence ID" value="KER19525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176729.1">
        <property type="nucleotide sequence ID" value="XM_009178465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8G7"/>
    <dbReference type="STRING" id="6198.A0A074Z8G7"/>
    <dbReference type="GeneID" id="20325897"/>
    <dbReference type="KEGG" id="ovi:T265_11729"/>
    <dbReference type="CTD" id="20325897"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23661" checksum="057A4B31CC83FC12" modified="2014-10-01" version="1">MVLALQVCFRLHVYPSRWFSKPPLTKNCLHFLPQFQSMVIKVLQGVDPNRKCMRIIGNVLIERRVKDILPALETNVQKMTECIDSLTKKFEEKGRELQRYKTEHKIRIVGEKEPNEPEKKGVSSSDMKSTCAENDAFLRSPWVPYVPDSSLKVFLIPPQYLVEADENSEVIITAELCFPTDLLSLWSIESIRNPESKSLIHMQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8J9</accession>
    <name>A0A074Z8J9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8J9"/>
    <dbReference type="GeneID" id="20324054"/>
    <dbReference type="KEGG" id="ovi:T265_09886"/>
    <dbReference type="CTD" id="20324054"/>
    <dbReference type="OrthoDB" id="6236380at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116186" checksum="A4154A42EF21FDAA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_07988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_07988"/>
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    <dbReference type="OrthoDB" id="6159439at2759"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13558" checksum="99A76167086FE96C" modified="2014-10-01" version="1">MPPEGSTRARFLPGCPSLDRGSREAEVGSLNSPPRSPLTIIQHGEVPVTSKTEILSKPTESLHVCEVKAIECAAPGRLMFQSLRYLKYRDTCIFVMYYSMNQISLQMSVYSLISCNLVSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC14</accession>
    <name>A0A074ZC14_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_08908</name>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20323087"/>
    <dbReference type="KEGG" id="ovi:T265_08908"/>
    <dbReference type="CTD" id="20323087"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KER23137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13522" checksum="6A446CE3881ECF32" modified="2014-10-01" version="1">MKKLINRSAVTPLRCLAAMPPEGCMRAGILPGCPNLDRGSREAEVGFEPRTFRSVNSRSNHLDYLALRDENANLFIVTPISFERSSSCSGVIIPVGPHQRKALDSSFALTRAHQQCISNGRAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCE7</accession>
    <name>A0A074ZCE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14676</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009174723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCE7"/>
    <dbReference type="STRING" id="6198.A0A074ZCE7"/>
    <dbReference type="GeneID" id="20328842"/>
    <dbReference type="KEGG" id="ovi:T265_14676"/>
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    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="693"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="308"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER23267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="755" mass="86032" checksum="DD811AC93BC7CC50" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCR4</accession>
    <name>A0A074ZCR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_07472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171269.1">
        <property type="nucleotide sequence ID" value="XM_009173005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCR4"/>
    <dbReference type="STRING" id="6198.A0A074ZCR4"/>
    <dbReference type="GeneID" id="20321651"/>
    <dbReference type="KEGG" id="ovi:T265_07472"/>
    <dbReference type="CTD" id="20321651"/>
    <dbReference type="OrthoDB" id="5953235at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703962" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="366" mass="40551" checksum="548794ECA71AA09B" modified="2014-10-01" version="1">MVSNLFFIATDALIIAISLDGDTNTVTDMARCSPAISSMEPLNPSCLLNEKYADIINCIRNFNWLPLPTRSYLVQRPKSSANETVTTIPLHGKYMVLTDDDDDDDDDDEDDDDDEDDDDDDDDEDDDDDSDDSDDDDDDDDDDDNDDDDDEDDDDGTSVSLFTQAHTEVTFTCPQEPTKGRFSFTLDSDQSTKMGAQERDRAHTQQCSKILGEKIAQKSDPCANQPCANNGTCILVDEAGVWIDSSLNEPTNAFDYKCLCGNGWTGKNCTVDVNDCIQDPCKNGGVCEDRPDMRYACHCAPGFVGQEILMTLCQSNLACQTEPHHSSLWFSHTKAVFKVIRFGIQKLSSALSRLMTYIATSFNPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDQ5</accession>
    <name>A0A074ZDQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170810.1">
        <property type="nucleotide sequence ID" value="XM_009172546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDQ5"/>
    <dbReference type="GeneID" id="20321282"/>
    <dbReference type="KEGG" id="ovi:T265_07103"/>
    <dbReference type="CTD" id="20321282"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12767" checksum="2BCAE5E546E32580" modified="2014-10-01" version="1">MFSNIVATGFEDRYNVRVTPLLGARWLKWLEYESTDLNVRGSKPTPASRFPLSRLSQPTSLIPKEGKHWTRVSVLLELISSGYPMAVLGFELRKSDVRSERVTTVPPAHVGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEH4</accession>
    <name>A0A074ZEH4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_08198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596824">
        <property type="protein sequence ID" value="KER24067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172191.1">
        <property type="nucleotide sequence ID" value="XM_009173927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEH4"/>
    <dbReference type="STRING" id="6198.A0A074ZEH4"/>
    <dbReference type="GeneID" id="20322377"/>
    <dbReference type="KEGG" id="ovi:T265_08198"/>
    <dbReference type="CTD" id="20322377"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
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            <end position="120"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="162"/>
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            <end position="203"/>
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            <end position="244"/>
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            <end position="591"/>
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        <location>
            <begin position="597"/>
            <end position="619"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="82"/>
            <end position="616"/>
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            <end position="305"/>
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            <end position="363"/>
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            <end position="305"/>
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        <source>
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    <evidence type="ECO:0000313" key="15">
        <source>
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        </source>
    </evidence>
    <sequence length="647" mass="72894" checksum="45A5C493D4D5D0F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEJ3</accession>
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        <recommendedName>
            <fullName evidence="16">Cyclic nucleotide-binding domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:inward rectifier potassium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
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            <end position="791"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="14">
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER25598.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112761" checksum="4728E98B13F857CF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEK8</accession>
    <name>A0A074ZEK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_14180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25613.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="405" mass="45517" checksum="F7C9F07504FACA7D" modified="2014-10-01" version="1">MFGVGCNVWQTLGSSGATSGVGGSYFLFGYIRATCYPAQNSGFLVRLVILIYVRNLILTQILASKYQSFTEKITGEIENREFQAIQTTHENVLWAHSACSQEIELSTAHISTKSNQRGSKPVKRKHCRAPSTAYTKYNRDLPTRVAATDSFASNLSFSLHHQKSAQKTFAILQMVRRTFSRITRMVFQILHEAYVRPLLEYANQVFYSGRTKYFTIIGRVQRAATKMFAGLKSVDYETPLAVLDLFPRTLFEQSLANRLFTVDPANTRRGHGKEILKLRAHTFIRQNFLISGNSCNEVQSATRHLFIRILALASILPRTENMKSSATPVFHLSFITAAERQGPNQPRNLGQKPRSCVSIRESVKPENSGLWPVNNVLGNVAAVRLSGIVALGGYKHEMSCVDWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEW2</accession>
    <name>A0A074ZEW2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170542.1">
        <property type="nucleotide sequence ID" value="XM_009172278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEW2"/>
    <dbReference type="GeneID" id="20321069"/>
    <dbReference type="KEGG" id="ovi:T265_06890"/>
    <dbReference type="CTD" id="20321069"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16546" checksum="6300459FD770177E" modified="2014-10-01" version="1">MVEYNTAFSWDFYSNVTMVTNKGIWAFDQLAIDLYDYSFYRTVRVKVIINYPLGFCDHYVLVSDLFCHKASNPKSQTRIRNFSAMRIFLKRVKLGPFSVEEADAVLVPNKQHAVGAAASYLKDSASSVKEAATMFQKMTMEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF41</accession>
    <name>A0A074ZF41_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171997.1">
        <property type="nucleotide sequence ID" value="XM_009173733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF41"/>
    <dbReference type="STRING" id="6198.A0A074ZF41"/>
    <dbReference type="GeneID" id="20322218"/>
    <dbReference type="KEGG" id="ovi:T265_08039"/>
    <dbReference type="CTD" id="20322218"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="565" mass="63675" checksum="CFA6C23D3551A117" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGP8</accession>
    <name>A0A074ZGP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171390.1">
        <property type="nucleotide sequence ID" value="XM_009173126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGP8"/>
    <dbReference type="STRING" id="6198.A0A074ZGP8"/>
    <dbReference type="GeneID" id="20321748"/>
    <dbReference type="KEGG" id="ovi:T265_07569"/>
    <dbReference type="CTD" id="20321748"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="38313" checksum="B094DE1274B3364D" modified="2014-10-01" version="1">MSAKLDEANEWIGKAEKSLKTSLFKRTPDYDSAIEYYTKAALLFRNAKQLERSAQLYEKVAELQLKHGSFFHAAKNYETASLLYRDLKDFDRMAELVTQAGELLRKCGAPDSASYLYEKTAKPLEQPLPERAAQFYELAADSCEVEEKYHAAADQCNNAARVWVRIRRFAEAERLLRLYIDYTEKGNPSSTYATLSGLADNTAVPKICARAVLVLILMKLHQGDEVAAGKIYSEAVQRWRFLEADENLSVRRLLGAFEECDGAAAAQAIKEPCFRTLDLDYARLVNEIKLPKVQTVKPKTERPTEPFVSSDGYSSPGSDRYDADSGNQNAVEEEEEEDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGZ9</accession>
    <name>A0A074ZGZ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RETREG1-3/ARL6IP-like N-terminal reticulon-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169672.1">
        <property type="nucleotide sequence ID" value="XM_009171408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGZ9"/>
    <dbReference type="STRING" id="6198.A0A074ZGZ9"/>
    <dbReference type="GeneID" id="20320382"/>
    <dbReference type="KEGG" id="ovi:T265_06200"/>
    <dbReference type="CTD" id="20320382"/>
    <dbReference type="OrthoDB" id="6416122at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052114">
        <property type="entry name" value="ER_autophagy_membrane_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952:SF0">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952">
        <property type="entry name" value="ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="6">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="367" mass="41777" checksum="D3EE6ABA70BA7D1E" modified="2014-10-01" version="1">MLVQQRYNFEEERDVNLLANDLSLLNWESPRLLVSILLIVSVIFLLLGMFHPAVLTMLGWFGLTMSVVDFIGPTLSARVAPEMHPLEAQKRYREFCRRLVHARYLVINFFTFLQELRANHPIAYLFTSLSLLMIGIFVGRHINDLLLLYILTIVCILTPGLRYKGFFTVRSNVLDSTPEVGLSDVLGRERSNVLRGITTSLNLTGHNLRKFSALWNVPALLMRVHHLGMSYAHNDVESMTSQPKATSYIIDKHLIQWNAHGLNPVVKRTLTNRKVCSLKQTPVLRLLLSRFKQLGSISILLFPSGGMAAGRRNGLRAERFKQNQSSNRLEWQSNGRDKLRGISRPEHIFTVEKHIGGTALNKSKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH27</accession>
    <name>A0A074ZH27_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171289.1">
        <property type="nucleotide sequence ID" value="XM_009173025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH27"/>
    <dbReference type="GeneID" id="20321671"/>
    <dbReference type="KEGG" id="ovi:T265_07492"/>
    <dbReference type="CTD" id="20321671"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10063" checksum="22BBE4A5822C5114" modified="2014-10-01" version="1">MGVSLTDVHADLIAGFTKKQEREVNGWTLGCPLQSRRVFGVLLYRWYLGVPGEDDGMREMSPWPVHTVRPAILPRSDGIYFIPGIHEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHC9</accession>
    <name>A0A074ZHC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171166.1">
        <property type="nucleotide sequence ID" value="XM_009172902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHC9"/>
    <dbReference type="GeneID" id="20321577"/>
    <dbReference type="KEGG" id="ovi:T265_07398"/>
    <dbReference type="CTD" id="20321577"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7984" checksum="4FB7B426740CE813" modified="2014-10-01" version="1">MNTRQVHEKFPEEGDYREGEQVKGSEWLRDGRQGDDITGEEGVEVSLLCGHHGYEFCKQEVINGRVISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHN4</accession>
    <name>A0A074ZHN4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173494.1">
        <property type="nucleotide sequence ID" value="XM_009175230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHN4"/>
    <dbReference type="GeneID" id="20328947"/>
    <dbReference type="KEGG" id="ovi:T265_14781"/>
    <dbReference type="CTD" id="20328947"/>
    <dbReference type="OrthoDB" id="6253906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="488" mass="52358" checksum="9302F58EA969DD7D" modified="2014-10-01" version="1">MVETALLEHIDPMLQPISSVRSPVPSSSLTPAPSLRPTKSTESEAEVGQTRLSSPGQQPTGPHPLRVTYDVAVGPSIQEQLAEEDRMQGVSTLHDIDDVSSHNGIPTPTPTMPEQSGGTLTKASDRVRARPEVHSVQTSPIHLPPASQSSSPLQSASTESLDITPLAADLPQIQSQAESTGQSEVFSLTLPNTFSDGVWLVDRSEGEAPLQVTSEAMQMLAGRLESNLFMQRSRSLASETEPESDTSALLRHQRSDGEIPTSGPLPKRGLRSGDPLTNPLLHLMALQQSSGFDISKLSERDRKVVMKTNAVMKRQGKKPRTAQSPENSYGQASIQPAESSPGLVKPVTMIDASEGDDGGESKMLEWLQSLAGSPAHRTVQSSHKSPPSKPSTNRTDPNKVSMLNGVEMVQSDDSDATEADVAEEEAYEDDYEPESKGNCSSPKSHKSADGPKDRPLTSGSSPPVWAREKVPDHMRHAVTLSDDSDDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZII2</accession>
    <name>A0A074ZII2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170627.1">
        <property type="nucleotide sequence ID" value="XM_009172363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZII2"/>
    <dbReference type="GeneID" id="20321136"/>
    <dbReference type="KEGG" id="ovi:T265_06957"/>
    <dbReference type="CTD" id="20321136"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="389" mass="44038" checksum="C41A60DF0FC90722" modified="2014-10-01" version="1">MVHDQATRYQHVQPGPAAYDSVYREALDYLNGAVLQLSSSPNLLSTQRTARELQKTAEYLAQLRLEDELFSQASPKWREKFAEREIVTQKQALLRIKEKLTDPGGQFLPRYRTNMDHGNAHCNTEQCATAELARPHGQDEGIGWTDTSIRAAHEWAERELVGLNTELEPLAEAAKKRIRQYSDEMDITNRYGGYRRNMGYMKKRNPEDLKALENTLDTSIGPPMAPRWHLGPEWIRAEAVGTQNYMAPGDDADCHVDRAQFMERYKLPQDKIKAAGIEASFPGRSEYQDEYLTPTFVETGMVSVLPPATHRSTFEQPVGVRGRGSMVGIDPVQVQLKGYGVNPTPNYLAAFDGAVPMSREVEPFPVSETKDSYRWPEKSKPKDVFLSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJX2</accession>
    <name>A0A074ZJX2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_05581</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168897.1">
        <property type="nucleotide sequence ID" value="XM_009170633.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZJX2"/>
    <dbReference type="GeneID" id="20319763"/>
    <dbReference type="KEGG" id="ovi:T265_05581"/>
    <dbReference type="CTD" id="20319763"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="363"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="566"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="923"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1394"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="948"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1333"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1363"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER27331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1713" mass="186559" checksum="F14C38FFA824A9BE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK49</accession>
    <name>A0A074ZK49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RhoGEF domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168829.1">
        <property type="nucleotide sequence ID" value="XM_009170565.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZK49"/>
    <dbReference type="GeneID" id="20319713"/>
    <dbReference type="KEGG" id="ovi:T265_05531"/>
    <dbReference type="CTD" id="20319713"/>
    <dbReference type="OrthoDB" id="9997817at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="207"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="725"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1783"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1828"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1855" mass="201096" checksum="8B792172DA951916" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK86</accession>
    <name>A0A074ZK86_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">T265_05502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168788.1">
        <property type="nucleotide sequence ID" value="XM_009170524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK86"/>
    <dbReference type="STRING" id="6198.A0A074ZK86"/>
    <dbReference type="GeneID" id="20319684"/>
    <dbReference type="KEGG" id="ovi:T265_05502"/>
    <dbReference type="CTD" id="20319684"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="434" mass="50397" checksum="063D43456D58C8A0" modified="2014-10-01" version="1">MVATEFIDFLNKLHVPDYIGVEDFADKLSFLYSVLVLMLCTTIVTVKQYLMSAIACYIPTVPSGSDFDKFLENFCWVHGTIPLLSNELIPQTMDEWAYFDDKYRINYYQWVPFMLGLQCMLFYIPRIVWQLICCNRTGTDIEHLVVVAHQASNAAPADRSKLVSHVTASLKGMLYQHREYRHGRVLEAKKRLFDACGLLVVSKRLGTWLAFTYFVIKLLYLTNSVGQLYLMQRFLGFNATLTNFGAKLADYMLSGRNWEQTRIFPRISFCYFADLRQLGSTNRYVAQCVLPVNMLNEKLYIFLWYWTAMVAILTAFSIPLWLMRLTFAKSRVRFIKKFLRINEQFHRSDKQLVKDFTENFLHHDGIFILRMISMNAGDVITSEVVSELWKGFYAEHNSTEPVGPEPSAPLPLADHNEDKALEKNHMARSRKSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKW4</accession>
    <name>A0A074ZKW4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_06343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169840.1">
        <property type="nucleotide sequence ID" value="XM_009171576.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZKW4"/>
    <dbReference type="GeneID" id="20320525"/>
    <dbReference type="KEGG" id="ovi:T265_06343"/>
    <dbReference type="CTD" id="20320525"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="1692"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="1082"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
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    <sequence length="1889" mass="207844" checksum="3919825DEB1D20F5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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            <taxon>Opisthorchiata</taxon>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM29</accession>
    <name>A0A074ZM29_OPIVI</name>
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            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZM29"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="GPATCH3"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER28111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="530" mass="60957" checksum="6AF53E4A70D37B89" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMD1</accession>
    <name>A0A074ZMD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168016.1">
        <property type="nucleotide sequence ID" value="XM_009169752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMD1"/>
    <dbReference type="GeneID" id="20319074"/>
    <dbReference type="KEGG" id="ovi:T265_04892"/>
    <dbReference type="CTD" id="20319074"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9362" checksum="A3AA10CB85A3C3CA" modified="2014-10-01" version="1">MIGRKEPVEEVGRLPYAARGQANATCAVTREHHNDRRLKELGIWVSLKLPFSLHQDKSSEKAFAILRMIRLTLSRITRMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPB0</accession>
    <name>A0A074ZPB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167028.1">
        <property type="nucleotide sequence ID" value="XM_009168764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPB0"/>
    <dbReference type="GeneID" id="20327577"/>
    <dbReference type="KEGG" id="ovi:T265_13410"/>
    <dbReference type="CTD" id="20327577"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="157"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="32324" checksum="1E1B8A6151C6D801" modified="2014-10-01" version="1" fragment="single">MVLQEYQSNFTLSSNQKQTDRQVLRSRVVQSEPERRQSRAIMPVLCPDRSRFDLFQTGARWRKWLECEFTDRKVRGSNPTSAYRLPLSGVEQLGSIPALVLASGDMVVRHLSGATSERTNECVRGLNSTSASRLPLSRVGQPGSIPALVLSSCSMAARYRKGATAETKLAPNHPDYVEAQRQFQEAFESSHDAMANFLESDAEHIEMLSNFVSAQMSYFQDAQRVLSDLQTRLQSKSVVRTRPLPFDFPCQGLGNLVVSQSSYFLQVAWQLGTGRMLQLDDLSDPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPH4</accession>
    <name>A0A074ZPH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171072.1">
        <property type="nucleotide sequence ID" value="XM_009172808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPH4"/>
    <dbReference type="GeneID" id="20328424"/>
    <dbReference type="KEGG" id="ovi:T265_14258"/>
    <dbReference type="CTD" id="20328424"/>
    <dbReference type="OrthoDB" id="413835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6890" checksum="DFAC7E79715D8FB5" modified="2014-10-01" version="1" fragment="single">RLKHEAAWCSTFSCLRTPQAKDSAGFQCLQNPGVQKACEENLVDLKYAVNIVLMFEEEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQY0</accession>
    <name>A0A074ZQY0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166718.1">
        <property type="nucleotide sequence ID" value="XM_009168454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQY0"/>
    <dbReference type="STRING" id="6198.A0A074ZQY0"/>
    <dbReference type="GeneID" id="20327510"/>
    <dbReference type="KEGG" id="ovi:T265_13343"/>
    <dbReference type="CTD" id="20327510"/>
    <dbReference type="OrthoDB" id="6255742at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17249" checksum="851A5F4C813C7DDE" modified="2014-10-01" version="1" fragment="single">MSMFMEAAMLPSPEEGRIRKGRPQKPHTPIAQRLTQPTVVVFLDLKAAFDSVDRQALWQCLWSKGVPHKFLTLIKGLYTNSRNGVKVYGKLCPEFTTSTGVRQGCPLSPFLFNFVIDTIMKDALPASNACGVEVLPGPPLTDIEYADDIALLGSDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSB6</accession>
    <name>A0A074ZSB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169978.1">
        <property type="nucleotide sequence ID" value="XM_009171714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSB6"/>
    <dbReference type="GeneID" id="20320625"/>
    <dbReference type="KEGG" id="ovi:T265_06446"/>
    <dbReference type="CTD" id="20320625"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="16006" checksum="C090D348260E2AA7" modified="2014-10-01" version="1">MMRRKGYDENGHTEQVWWNMIEKHEASGLGMEKAAGAKKQERSREEGLRTNLWRCIVWKTGNTNYVKYESPTLRSKAYVCRRDTLSRDVQRITTDEEKRKRSLHCYYEFVEESVTLSLRKERETRNLINRPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTE3</accession>
    <name>A0A074ZTE3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165551.1">
        <property type="nucleotide sequence ID" value="XM_009167287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTE3"/>
    <dbReference type="GeneID" id="20317111"/>
    <dbReference type="KEGG" id="ovi:T265_02923"/>
    <dbReference type="CTD" id="20317111"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="16935" checksum="345C3FAD6203DABC" modified="2014-10-01" version="1">MTDCNYESARDSFSDAAGVLLHLAKTSDHVVISGKLKAQFDMLSIPAAQLAGRLALIMGRTDNIEHLLQAILVYMCSLAYTAVKLLVADVANFNEYPAPSSQNTYHGFTHDADMLDVGQPARLTPDTSPTFGVPRFDTGPTETGGLFPAKPMDAYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTP3</accession>
    <name>A0A074ZTP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167099.1">
        <property type="nucleotide sequence ID" value="XM_009168835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTP3"/>
    <dbReference type="STRING" id="6198.A0A074ZTP3"/>
    <dbReference type="GeneID" id="20318351"/>
    <dbReference type="KEGG" id="ovi:T265_04165"/>
    <dbReference type="CTD" id="20318351"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000075">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="24705" checksum="F49A4DB9F220CE48" modified="2014-10-01" version="1">MVHMTGWPKGSSEKFLQSTPVAKTITLYPLKSYSFGTKDPNYERDRSVPARFQRLQEDFDKYGMRRSVEGVLLVHEHNLPHVLLLQLGTFFKLPGGELNPGEEELEGLKRLLSEMLGRTDGVPVGWVPEDCIGNWWRPNFEPPRYPYIPAHVTKPKEHTRLFLMQLPEKTLFAVPSNYKLVAAPLFELFDNARAYGPIISSLPQVLSRFNFVYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU51</accession>
    <name>A0A074ZU51_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598366">
        <property type="protein sequence ID" value="KER18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177534.1">
        <property type="nucleotide sequence ID" value="XM_009179270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU51"/>
    <dbReference type="GeneID" id="20330033"/>
    <dbReference type="KEGG" id="ovi:T265_15868"/>
    <dbReference type="CTD" id="20330033"/>
    <dbReference type="OrthoDB" id="10481337at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="971" mass="110419" checksum="F13F35ECFD4CC70F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUL3</accession>
    <name>A0A074ZUL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165459.1">
        <property type="nucleotide sequence ID" value="XM_009167195.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZUL3"/>
    <dbReference type="GeneID" id="20317039"/>
    <dbReference type="KEGG" id="ovi:T265_02851"/>
    <dbReference type="CTD" id="20317039"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13313">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705524" description="Ras-GAP domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="3568"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="1607"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2607"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3090"/>
            <end position="3112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3235"/>
            <end position="3302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2607"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3245"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3286"/>
            <end position="3297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3568" mass="385407" checksum="C3D14675C1E4B9D3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUU4</accession>
    <name>A0A074ZUU4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUU4"/>
    <dbReference type="GeneID" id="20316919"/>
    <dbReference type="KEGG" id="ovi:T265_02731"/>
    <dbReference type="CTD" id="20316919"/>
    <dbReference type="OrthoDB" id="6239805at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64360" checksum="11F10C32FB2E9CD6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV01</accession>
    <name>A0A074ZV01_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_02475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV01"/>
    <dbReference type="GeneID" id="20316663"/>
    <dbReference type="KEGG" id="ovi:T265_02475"/>
    <dbReference type="CTD" id="20316663"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7054" checksum="4201428A42D28E01" modified="2014-10-01" version="1">MTYPGNLSYHPTPPCIDSLFTCSQEAAIEVEIEDNDGGDDDLIVEPNGKRPGEGHIHGILMSQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV23</accession>
    <name>A0A074ZV23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV23"/>
    <dbReference type="STRING" id="6198.A0A074ZV23"/>
    <dbReference type="GeneID" id="20329847"/>
    <dbReference type="KEGG" id="ovi:T265_15682"/>
    <dbReference type="CTD" id="20329847"/>
    <dbReference type="OrthoDB" id="9449045at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HGPRT"/>
    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43340:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="24445" checksum="16B73EE3BED5DBA8" modified="2014-10-01" version="1" fragment="single">IPDEFSGYSACDFRLSQRYNKYIEGILVPRGMILDRLEKMALDILDNLEKRGSTSLTLLCILKGAFKFAADLCEQLEAAAFSRQKNITIHLDFVVANTYVNDRVGHETRLTMCSDPGKYENKDILVVEDLVDTGTTLHKLYSYLKSLNPRSIEAACLLVKRRQDCVSFDPDYVGFEVPDRFIVGYSIDYSDHFRELPHICVVNDQGKKQFAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV94</accession>
    <name>A0A074ZV94_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164849.1">
        <property type="nucleotide sequence ID" value="XM_009166585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV94"/>
    <dbReference type="GeneID" id="20327139"/>
    <dbReference type="KEGG" id="ovi:T265_12971"/>
    <dbReference type="CTD" id="20327139"/>
    <dbReference type="OrthoDB" id="6253705at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="463" mass="53267" checksum="39D037B3A2B3EDF1" modified="2014-10-01" version="1">MTSFALLEAYQAPSLTFGQLYVLLELKLHDIKTERFSWVPVRDPNLKHFVTDQMVGGGDAGLTGVDHEGTGRVRNNRERRRQHEANELQKQIEALNSTIERLIERTKEKAEVLNNVIQETLKQIKMICLQRETKRRHKMKEKRQITRALFLRHFRDRQTRKRRLRLKLGLNNIRTQRSHLGPIPASLASKEQDESDALRKWEANEDKRDEAENALAVKQEEEAAVKATSKLKWLKEVTNAHLKHLEEFLKVTNPQESDDATSNINDSSLEFQLPVLRSRHYRLVTLLHKYGITSEDEEKISSNTCQSLLDSKSVSATIALRNLWTDLAGDKLCRMQRAAIGQFERLIQQGCRSPLARSFMSPTSKQHRQWRREAAILQHFGKVISGKHFSYFDFWPAPAVESSDEGESDASDKSSDGQRKHEKLPAVSAGPSKGEAHRPQDPRKRKNEPVKKLNIGRQNIRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVS9</accession>
    <name>A0A074ZVS9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165052.1">
        <property type="nucleotide sequence ID" value="XM_009166788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVS9"/>
    <dbReference type="GeneID" id="20316713"/>
    <dbReference type="KEGG" id="ovi:T265_02525"/>
    <dbReference type="CTD" id="20316713"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="19063" checksum="C3BE803705B16766" modified="2014-10-01" version="1">MSPHTTRIIWILSRYLHPDKTGKERKDPTSFHPAPICGDGDHERAQGSDPRRAMSSAYSMSVSGGPGSTLTPEALEAGDVDLRWEKLIRGSEGNSSHLLAVRHELFCQHIASFQLVQSSPVLLQIYFPAPDKNTCVDSYHVLSYCCFTMHLTKPREIPSSGPITGIPSDSSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWW0</accession>
    <name>A0A074ZWW0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164273.1">
        <property type="nucleotide sequence ID" value="XM_009166009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWW0"/>
    <dbReference type="GeneID" id="20316071"/>
    <dbReference type="KEGG" id="ovi:T265_01883"/>
    <dbReference type="CTD" id="20316071"/>
    <dbReference type="OrthoDB" id="6224799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22048" checksum="DAC5B6AEB57EBFDF" modified="2014-10-01" version="1">MLVNHFRNGHKLNTVYYFYFHITKFDHSTSADVWNQIIKDSILGSGLIVKAVLCNRSSRAIYAYGPQDFTPSVQQIDVSTICDHLEGCRILGLQCVLFSELLNKRLAEDADKNVVNPNFCIALEECTYKDVTDDKILLASVNKSDLLQSDQSTATYELASVVTTNSLLIGIYPLAGNQEAAKQLLCDMRDYLQDQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX49</accession>
    <name>A0A074ZX49_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168324.1">
        <property type="nucleotide sequence ID" value="XM_009170060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX49"/>
    <dbReference type="GeneID" id="20319318"/>
    <dbReference type="KEGG" id="ovi:T265_05136"/>
    <dbReference type="CTD" id="20319318"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9687" checksum="F734BE6B2D3C3984" modified="2014-10-01" version="1">MLNMVKGTGYKVVDEHILGMNITPVFDRTCAGLESGSDDDVDNDGDDDDDEEEEEEEKDGDDDDEDDDDDDDDDDDDDADDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXH2</accession>
    <name>A0A074ZXH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597121">
        <property type="protein sequence ID" value="KER19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176359.1">
        <property type="nucleotide sequence ID" value="XM_009178095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXH2"/>
    <dbReference type="STRING" id="6198.A0A074ZXH2"/>
    <dbReference type="GeneID" id="20325607"/>
    <dbReference type="KEGG" id="ovi:T265_11439"/>
    <dbReference type="CTD" id="20325607"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054361">
        <property type="entry name" value="Znf-CCCH_ZC3H4/6/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22623">
        <property type="entry name" value="zf-CCCH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="664" mass="73923" checksum="BAE8DE0ED68C242B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXK1</accession>
    <name>A0A074ZXK1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164159.1">
        <property type="nucleotide sequence ID" value="XM_009165895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXK1"/>
    <dbReference type="GeneID" id="20327028"/>
    <dbReference type="KEGG" id="ovi:T265_12860"/>
    <dbReference type="CTD" id="20327028"/>
    <dbReference type="OrthoDB" id="72976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116138" checksum="C0E07ACF9CBCC797" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY39</accession>
    <name>A0A074ZY39_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase E1 component domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163914.1">
        <property type="nucleotide sequence ID" value="XM_009165650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY39"/>
    <dbReference type="STRING" id="6198.A0A074ZY39"/>
    <dbReference type="GeneID" id="20315779"/>
    <dbReference type="KEGG" id="ovi:T265_01591"/>
    <dbReference type="CTD" id="20315779"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="216"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="432" mass="48547" checksum="BE34A1D787399581" modified="2014-10-01" version="1">MFGRRLRCFELSKRVNSLLQRSFSVGVRNHAESATFNLSEYKRYMLDKEPPKQTVCSKEEAQNYIERMVRIRQMENACSNLYKERKVRGFCHLYAGQEAVGVGIEAGLKPGDAMITSYRCHGLMVTRGASVLSVISELIGRRTGASMGKGGSMHMYYKDFYGGNGIVGAQSSPREISTPMLSFAIICNKPSAEEQQSLDQFITRNLACPLRYYLYVPLGAGVALAMKYRKQENVCVDMYGDGAANQGQVFEAFNLAKLWKLPVIFLCENNKYGMGTADCRSSACIDYYTRASYIPGLWVNGMDVLSVREAIRFCRDWIMEGNGPIVFEAETYRYFGHSMSDPGTSYRTRDEVDLVRKQRDPINLFCQSVVSAGLLTDAEIKEINAVVKKEVAQDSDQAETNPEPDVELAYEHVHKQPIPGFPIRGCDILDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYE0</accession>
    <name>A0A074ZYE0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165253.1">
        <property type="nucleotide sequence ID" value="XM_009166989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYE0"/>
    <dbReference type="GeneID" id="20316875"/>
    <dbReference type="KEGG" id="ovi:T265_02687"/>
    <dbReference type="CTD" id="20316875"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21285" checksum="22D754C808535A81" modified="2014-10-01" version="1">MSAIEGATGPCLMWPVSGSPSRKTAVTSAAEFAGNGFHTSLPSHCLTASGSLPPFTWLGENSPSRKSVDWHTQHVAKPTQPMERDQFIYRGGQYDFTPRPPRATIARSAESRCSPLAFLAWLYLVERSSSQCSPRDHCSTQARPPRQGGSFRSKTTTHSKFRCQEQGISGWWDTPKEKYSVKMMPKAKGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYH0</accession>
    <name>A0A074ZYH0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597080">
        <property type="protein sequence ID" value="KER20194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176052.1">
        <property type="nucleotide sequence ID" value="XM_009177788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYH0"/>
    <dbReference type="GeneID" id="20325360"/>
    <dbReference type="KEGG" id="ovi:T265_11192"/>
    <dbReference type="CTD" id="20325360"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7669" checksum="9B0D183ADD1A27C5" modified="2014-10-01" version="1">MTNNEPNRSGHFYRIHRDLVVFKMVDMFWIPVNTMETCRINGTDDEVGEKRGQMKALLTTRGILIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYV9</accession>
    <name>A0A074ZYV9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_01325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163595.1">
        <property type="nucleotide sequence ID" value="XM_009165331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYV9"/>
    <dbReference type="GeneID" id="20315513"/>
    <dbReference type="KEGG" id="ovi:T265_01325"/>
    <dbReference type="CTD" id="20315513"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF0">
        <property type="entry name" value="LP20373P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="41161" checksum="6D7111925B3E1A62" modified="2014-10-01" version="1">MRNYLPHLPSPSVNEAVAARATVQQLRGSALISQHLTHQLCAEIVCSWLVDRIVHVSDDTADHCTLSNTSKNESYNLRILLHILFIILLATKLYFEHFLEILLLLWLFASTLYVHKSIRQDVFSRCHDERVYDCLLSSSVATCYLIFLHFSLGDRGLYRIFVFLPPYSAMDDLWFVFWTCALVDGTMKIVSSLCKSLFVIIPRRNLSTYRLGTVLVTLECCSLVIRNIYPCFIWILFFTEINGSYQSPLFQKILLTMFYCVLKIGSFVYCLRSLKQVWQSLFAPPPFKVEPLVTQRCILCRGDYTLAGVLRCNHSVCESCVQTWCSRHTFCPTCNVTFSHQTQWRDGSMDLFIQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYZ0</accession>
    <name>A0A074ZYZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165035.1">
        <property type="nucleotide sequence ID" value="XM_009166771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYZ0"/>
    <dbReference type="GeneID" id="20316696"/>
    <dbReference type="KEGG" id="ovi:T265_02508"/>
    <dbReference type="CTD" id="20316696"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="13258" checksum="58693F7FAFD17952" modified="2014-10-01" version="1">MKEWEYGFQRMNLMTRRGFRIVQLETKERLFVSKTVNSSEIIPVATEPEAFSTVIEWRGPQITNLRPNSAIKTEEISNPEKPCVSNISLFIGEVWLEMEWLPPNFLGRPSSTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ00</accession>
    <name>A0A074ZZ00_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165048.1">
        <property type="nucleotide sequence ID" value="XM_009166784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ00"/>
    <dbReference type="STRING" id="6198.A0A074ZZ00"/>
    <dbReference type="GeneID" id="20316709"/>
    <dbReference type="KEGG" id="ovi:T265_02521"/>
    <dbReference type="CTD" id="20316709"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12439">
        <property type="entry name" value="RRM_TRMT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034262">
        <property type="entry name" value="TRMT2A_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="672" mass="75784" checksum="D9EE44141F36B416" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZX1</accession>
    <name>A0A074ZZX1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009177308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZX1"/>
    <dbReference type="GeneID" id="20324997"/>
    <dbReference type="KEGG" id="ovi:T265_10829"/>
    <dbReference type="CTD" id="20324997"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7476" checksum="62A152811E088D6A" modified="2014-10-01" version="1" fragment="single">ATRRKHEGWDTDRLPEPRWRKSRGRGRLQTTNLLEHPTVGERADQDCRQHVSANATWIGQRSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0E5</accession>
    <name>A0A075A0E5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009166237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0E5"/>
    <dbReference type="STRING" id="6198.A0A075A0E5"/>
    <dbReference type="GeneID" id="20316266"/>
    <dbReference type="KEGG" id="ovi:T265_02078"/>
    <dbReference type="CTD" id="20316266"/>
    <dbReference type="OrthoDB" id="6273172at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="328" mass="35622" checksum="4B7D882A82404CEA" modified="2014-10-01" version="1">MPFSLERNGSQIASVVVKEGLLSLWLPQKSKWQNVYCKLQQSGWFYWFHKSGYRKPIHGVDLKVVAAFFAHGELTKALSVRPAGMIDADYERAFALTKEPVVGSEIFFFLCSNMAEMKSWVTSIFTVLGQPVPAEYQVSTIGIAYQQGNPVCTQGVGIPVSVNAATSFPLLLVRPYSGTSSPTATTQQILPTQRTASPTPTGHNLNPPIQQSSSVPTLFRLIPSSASPLPSATVPAMQQAAFPIMAQPLVLQPVTQIPHPLPNGESKGPFRSLSDAGNIVKEASAQGRPLEKGTPKPHGKSSHSDNQRDFISSPKVTSQQSLFRRIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0I8</accession>
    <name>A0A075A0I8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163045.1">
        <property type="nucleotide sequence ID" value="XM_009164781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0I8"/>
    <dbReference type="STRING" id="6198.A0A075A0I8"/>
    <dbReference type="GeneID" id="20315074"/>
    <dbReference type="KEGG" id="ovi:T265_00886"/>
    <dbReference type="CTD" id="20315074"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="694" mass="78895" checksum="735E6CC4FB3C680B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0T4</accession>
    <name>A0A075A0T4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162988.1">
        <property type="nucleotide sequence ID" value="XM_009164724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0T4"/>
    <dbReference type="GeneID" id="20326810"/>
    <dbReference type="KEGG" id="ovi:T265_12642"/>
    <dbReference type="CTD" id="20326810"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="10843" checksum="3E1F6F3461F20D96" modified="2014-10-01" version="1">MCSPIAVDTMAVTDLRTPVEVGIPAAAGLHTLVGADNTIVVDLLIPNRADILAASDLGTGLDNRKVEHSDNQTLVDIHLDSLDTVLEVTGRLNSTHCSRLAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Y4</accession>
    <name>A0A075A0Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163121.1">
        <property type="nucleotide sequence ID" value="XM_009164857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Y4"/>
    <dbReference type="STRING" id="6198.A0A075A0Y4"/>
    <dbReference type="GeneID" id="20315130"/>
    <dbReference type="KEGG" id="ovi:T265_00942"/>
    <dbReference type="CTD" id="20315130"/>
    <dbReference type="OrthoDB" id="6276858at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05484">
        <property type="entry name" value="retropepsin_like_LTR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034128">
        <property type="entry name" value="K02A2.6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="7">
        <location>
            <begin position="351"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="518" mass="57855" checksum="4E36929A29B636E7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I7</accession>
    <name>A0A075A1I7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Signal sequence receptor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_12658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163104.1">
        <property type="nucleotide sequence ID" value="XM_009164840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I7"/>
    <dbReference type="STRING" id="6198.A0A075A1I7"/>
    <dbReference type="GeneID" id="20326826"/>
    <dbReference type="KEGG" id="ovi:T265_12658"/>
    <dbReference type="CTD" id="20326826"/>
    <dbReference type="OrthoDB" id="10059529at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009779">
        <property type="entry name" value="SSR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07074">
        <property type="entry name" value="TRAP-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18736" checksum="F35E5EE066F98005" modified="2014-10-01" version="1" fragment="single">MAVKITKEDELLLEMYSRAASKKSDHLIYGNAILISLIPIWLFWRIHGLALVANSILYVIVSTACAFLMSYAYTGAKAPLMERFVLMLDIVYVAAKRSESISKELAAETGKDKKLTRKERDDAVRERTREVADYESTTYSIFFNNCVYLLILLASSMVLQHFSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1P2</accession>
    <name>A0A075A1P2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162913.1">
        <property type="nucleotide sequence ID" value="XM_009164649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1P2"/>
    <dbReference type="STRING" id="6198.A0A075A1P2"/>
    <dbReference type="GeneID" id="20314965"/>
    <dbReference type="KEGG" id="ovi:T265_00777"/>
    <dbReference type="CTD" id="20314965"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15197">
        <property type="entry name" value="7tmA_NPSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027294">
        <property type="entry name" value="NPS_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24244:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24244">
        <property type="entry name" value="NEUROPEPTIDE S RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="107"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="439" mass="49189" checksum="5D15206DDB1E4ECA" modified="2014-10-01" version="1">MLYKNQSSVTRNITFVNQDDMRKMECRRITNAGQRPNDALDTGHRIDLENVEVLRRGLRFTPQRLIAEAVEITKHHSVNRIEGVELASIGDIGFGISLVLLVIIVTGNVSVLVALLYRNVKNQMRWFIVNLAATDLCVAIAGVLPECILDYTSQFRAPIAICKLVKYMASASTYASSFALIVLSIDRAEAVCRPLRVATSGVSSKTQARLLICGAWFVASLCGLPGLILAQKTGEGTDREACYLNFRTVDTKVYMTCIAVSVFMIPATIIAICHIIMVTTIWKASKLQPALFDHGEKRGRNECEPTCRSPEYPPHVKDHRRLRLAIPKYVRHKRSSTDGFLHKPSQSANIAAGCIPRARIKTVKMTFVIVSVYIICWCPFMVWNLLVTFEVLDRKARTLLMYTPLIQKLVPLNSATNPLIFWIFNARSIRSQPPQPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1R7</accession>
    <name>A0A075A1R7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="11">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_01776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="11"/>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164130.1">
        <property type="nucleotide sequence ID" value="XM_009165866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1R7"/>
    <dbReference type="STRING" id="6198.A0A075A1R7"/>
    <dbReference type="GeneID" id="20315964"/>
    <dbReference type="KEGG" id="ovi:T265_01776"/>
    <dbReference type="CTD" id="20315964"/>
    <dbReference type="OrthoDB" id="67310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000027">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="334"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="618"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="840"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129505" checksum="A3C58A4BEF00A184" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A241</accession>
    <name>A0A075A241_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163864.1">
        <property type="nucleotide sequence ID" value="XM_009165600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A241"/>
    <dbReference type="GeneID" id="20315729"/>
    <dbReference type="KEGG" id="ovi:T265_01541"/>
    <dbReference type="CTD" id="20315729"/>
    <dbReference type="OrthoDB" id="6282792at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12322" checksum="472EA69D9090656C" modified="2014-10-01" version="1">MYEKSLSLKFLESPQTSFREFATRGSSQHVRTLCQNGRQVMLAETLYSLKIDVCCVSETRIQDPSLVMHLITPRMNSALSNFSLRVSGDPGQTIVTKKPSFQPQTPGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A251</accession>
    <name>A0A075A251_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162494.1">
        <property type="nucleotide sequence ID" value="XM_009164230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20314645"/>
    <dbReference type="KEGG" id="ovi:T265_00457"/>
    <dbReference type="CTD" id="20314645"/>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705418" description="Cadherin domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="283"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="380"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="530"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="649"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="812"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1325" mass="146921" checksum="8B6B6FD66200A075" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A339</accession>
    <name>A0A075A339_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166241.1">
        <property type="nucleotide sequence ID" value="XM_009167977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A339"/>
    <dbReference type="STRING" id="6198.A0A075A339"/>
    <dbReference type="GeneID" id="20317664"/>
    <dbReference type="KEGG" id="ovi:T265_03477"/>
    <dbReference type="CTD" id="20317664"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER29995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="10415" checksum="5D87CAF46067215A" modified="2014-10-01" version="1">MADRVTVLNTEMNKEMLEYAVETTREAFEKYNVETQIAEFIKKRLDEKYARSWHCVVGTWYGSYVTHEHGHFVDMMYGNKAVLLFKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A367</accession>
    <name>A0A075A367_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163617.1">
        <property type="nucleotide sequence ID" value="XM_009165353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A367"/>
    <dbReference type="STRING" id="6198.A0A075A367"/>
    <dbReference type="GeneID" id="20315535"/>
    <dbReference type="KEGG" id="ovi:T265_01347"/>
    <dbReference type="CTD" id="20315535"/>
    <dbReference type="OrthoDB" id="6430345at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059089">
        <property type="entry name" value="Kazrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="261"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="905" mass="100006" checksum="87A9676F9DAD4A6A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3F2</accession>
    <name>A0A075A3F2_OPIVI</name>
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            <fullName evidence="3">Intraflagellar transport protein 25 homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">T265_12439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009163855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3F2"/>
    <dbReference type="STRING" id="6198.A0A075A3F2"/>
    <dbReference type="GeneID" id="20326607"/>
    <dbReference type="KEGG" id="ovi:T265_12439"/>
    <dbReference type="CTD" id="20326607"/>
    <dbReference type="OrthoDB" id="271080at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:intraciliary transport particle B"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033558">
        <property type="entry name" value="IFT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15297" checksum="CE88C18E57CECCFE" modified="2014-10-01" version="1">MLSSSSHADKFVKLATSLDEQHPPENVLDSDDKSFWITTGMFPQMLVLSLTENTKVGNVTVISSCIKNMWVEVSSNPDPEEFDLKSELTIPYTDGHLQITEVRVNEQNMRHLRLTIRSGYDHFVAVYKVLIDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3J0</accession>
    <name>A0A075A3J0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163427.1">
        <property type="nucleotide sequence ID" value="XM_009165163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3J0"/>
    <dbReference type="GeneID" id="20326891"/>
    <dbReference type="KEGG" id="ovi:T265_12723"/>
    <dbReference type="CTD" id="20326891"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="20460" checksum="07EC5B4F57E2B45A" modified="2014-10-01" version="1" fragment="single">TDSGHGRSSTTDNGVAPANESKATKGELHPPMTKEHTDPDIGLLTIPTLQSPRSKCNTLPSKCNLEKIAKDEASDSALDIPDRSPVSTSQGQSQLQKARQSVTWKEADYQTCNQDDQHKRTVGCLIGNQHSSGSHANLPGEMDESSEGTLVLFSPVDTSGYAQLVRPSLPSLTEQGSPKHSLYSAFPTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A482</accession>
    <name>A0A075A482_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161942.1">
        <property type="nucleotide sequence ID" value="XM_009163678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A482"/>
    <dbReference type="STRING" id="6198.A0A075A482"/>
    <dbReference type="GeneID" id="20314209"/>
    <dbReference type="KEGG" id="ovi:T265_00021"/>
    <dbReference type="CTD" id="20314209"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="390" mass="42238" checksum="CE92F08AD8D00B3A" modified="2014-10-01" version="1">MAVPVKLDDMQQLIKIATTSLNSKVVSQHSGALAPIAVKAVLEAVDPSSPHTVTLDDVRVVKKLGGTVEDTELVDGLILTQRVAPGCGVKRVEKAKIGLIQFCVSPPKTDMENTVIVTDYTQMDRIMKEERQYILNIVKAVKKAGCNVLLIQKSILRDAVNDLALHYFSKMNIMVVKDIERTEVEFICKTLHCTPIASLDHFNPEYLGSANLVEESEATARCVRITGIQNKGRTVSILVRGSNKLMLDEAERSLHDALCVIRCLVKKGALVAGGGAPEIEVAQKLALLANTTPGLDQYCFRAFADAFEVVPYTLAENAGLNPIQTVTELRALHARGQVNAGIDVRMGAVADILSQDVMQPVLVSHSVVSLAAETVRSILKIDDVINAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4F7</accession>
    <name>A0A075A4F7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162014.1">
        <property type="nucleotide sequence ID" value="XM_009163750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4F7"/>
    <dbReference type="GeneID" id="20314281"/>
    <dbReference type="KEGG" id="ovi:T265_00093"/>
    <dbReference type="CTD" id="20314281"/>
    <dbReference type="OrthoDB" id="10608140at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="28451" checksum="D0205778AA0C40BD" modified="2014-10-01" version="1">MQRDLNPRYIIKRCWSGVGEDSRARKMEHALMEICGEETSGTEAVCEQAFNTISAAPESEDRRGAAREFGKPSEDVGFSLVKNFDGSSSSSSSSKTASNVTTLMLHCRTTIRVKREKGGRRRVPSTEVPTPPTAQANWKLTARTPLTSITRHLLPQTGSRGPHPGRYTTPTTPKIFVISFKPFCQVMCCPPRGLRHAEGGTENNTRLRRWRLPSTDGVTGTPSWKVYNTNNTQNLRDLFQAFLPSHVLPTSRFAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4K8</accession>
    <name>A0A075A4K8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165662.1">
        <property type="nucleotide sequence ID" value="XM_009167398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4K8"/>
    <dbReference type="GeneID" id="20317196"/>
    <dbReference type="KEGG" id="ovi:T265_03008"/>
    <dbReference type="CTD" id="20317196"/>
    <dbReference type="OrthoDB" id="10353556at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="15752" checksum="CCD65B235A2596A5" modified="2014-10-01" version="1">MLLSAKITLLIAASIGLVITLVPIIQYDYLWRRPPIELVDACNLQIAALCTYIVLIVFISLSSLLPIKDKFVLLAYFFFGLLATSLEVGAYIAVAYPNFRNRPLPTITEWTFGGIFATLPLLFGTILIAAYDVYGLIQRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5U4</accession>
    <name>A0A075A5U4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173453.1">
        <property type="nucleotide sequence ID" value="XM_009175189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5U4"/>
    <dbReference type="STRING" id="6198.A0A075A5U4"/>
    <dbReference type="GeneID" id="20323357"/>
    <dbReference type="KEGG" id="ovi:T265_09178"/>
    <dbReference type="CTD" id="20323357"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14187" checksum="4BBB397F6A8F1B64" modified="2014-10-01" version="1">MGGAERRSQSQPRLQDCFAQTTQTCQSPYPENGYYHAPSSPPSREQTTTYEDALNHGIRQPRQRWINTNLGAVRCANCPDVVFANERVDACGKAFHRLCFKCTSCRRLLDRGTACDHKKEIFCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7P7</accession>
    <name>A0A075A7P7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_08621</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596847">
        <property type="protein sequence ID" value="KER23499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172747.1">
        <property type="nucleotide sequence ID" value="XM_009174483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7P7"/>
    <dbReference type="STRING" id="6198.A0A075A7P7"/>
    <dbReference type="GeneID" id="20322800"/>
    <dbReference type="KEGG" id="ovi:T265_08621"/>
    <dbReference type="CTD" id="20322800"/>
    <dbReference type="OrthoDB" id="5951059at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="70"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER23499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="427" mass="48140" checksum="1E64FE5E04AC130B" modified="2014-10-01" version="1">MINVKGFENNLTTVGNFTPLQCTLLLRLAYDGIRVEPEEILRCLQHPYTLTEGIIVAIVLLLLSLLTAFGNMLIGIAILIVRRLRNPANLLLFNLAASDFLISVIVLPFAIVQQVRGYWPFNELLCDLYIVFDVLLCTASILSLCAIAVDRYFAITRPLTYASSRTIKRMLIMIIVCWIMAALISIPPFFGLQEKVSIPYHCGYTDDLTYQVYATFAAFYIPLIVMLVLYGRVYAIVRKVTVQDSLIAMRLNKGSIDTQRSATITEQIIRTDDTQSALITSTLQLPYSGMLDRSSSTLEFAQQKPSFPQIDQSDYRHLDRNSGTIPDGYLRANIRNHDMRHMTTCDGNSPSVWSSRSRSRCRQSRVPGSTMERRVRRKTVTPTSENMKAVVTLGVIMGSFTLCWLPFFLYQVSQAVAVLTLDSVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7Q6</accession>
    <name>A0A075A7Q6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 UFM1-protein ligase 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164613.1">
        <property type="nucleotide sequence ID" value="XM_009166349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7Q6"/>
    <dbReference type="STRING" id="6198.A0A075A7Q6"/>
    <dbReference type="GeneID" id="20316363"/>
    <dbReference type="KEGG" id="ovi:T265_02175"/>
    <dbReference type="CTD" id="20316363"/>
    <dbReference type="OrthoDB" id="10365477at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="32574" checksum="D4047FD52E51FB84" modified="2014-10-01" version="1">MERGISGIDRPVLQMQLIRHLAKSHGACLVDRLCVHLAQTYGVQWPTPASSNKPDDQKDSTGAIQTDSPSPSSPDFVNPMTPDQRQQLVEMLKHSGAADAAQTSSALQNVIEKMRAIQQTANVGLTDYYLAVEALATDHTGISLPTLHARVDNKRRKEERSKANELALQVELQLQTAIEALHKEADMRLAATASLAAVCLFAQVATGWPVTAPGKCVPDLVSWLSDFVSSRRSSNNSKETTTSPALQALLNSTAIPDLVELTALISQHMHSGIDISFNTDLGTKFEQVVNVAKQCRKLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8T6</accession>
    <name>A0A075A8T6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LAO/AO transport system ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164104.1">
        <property type="nucleotide sequence ID" value="XM_009165840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8T6"/>
    <dbReference type="STRING" id="6198.A0A075A8T6"/>
    <dbReference type="GeneID" id="20315938"/>
    <dbReference type="KEGG" id="ovi:T265_01750"/>
    <dbReference type="CTD" id="20315938"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43534" checksum="8B2901A25BA2F28B" modified="2014-10-01" version="1">MFRSFNLSCLHSLKPCSRYLKKPDKLSFDGQLRIPPHTSTCGSRFFRSISDDFCVPNSIRELKERLFAGDRRSLAQSITLIESKNPDRRREGLSGPPGAGKSTFIEALGTRLIGLVPWVSDLPEQAQKGPYGKRGSNEPVPVPTENHRVAVLAVDPSSVTTGGSLLADKTRMYELSRHENAYVRPSPSGGNLGGVARSTNETVLICEAAGFDVVLVETVGVGQSEIAVADMVDLFILLIPPAGGDELQGIKRGIVEYADIVVVNKADGDLIAPARRIAAEYSNALKYQRMRRPNWRPQVMLASSYTGAGIVEFWNRVLEFKEMQIASKELQSVRKKQMKVWMWNYIKEGIWDHFRMHPAVRRQLTSIERKVEAGELAPGPAAESLINIFIQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAV6</accession>
    <name>A0A075AAV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07724</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171584.1">
        <property type="nucleotide sequence ID" value="XM_009173320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAV6"/>
    <dbReference type="STRING" id="6198.A0A075AAV6"/>
    <dbReference type="GeneID" id="20321903"/>
    <dbReference type="KEGG" id="ovi:T265_07724"/>
    <dbReference type="CTD" id="20321903"/>
    <dbReference type="OrthoDB" id="9997229at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="428" mass="48612" checksum="C2C65510E4E8D157" modified="2014-10-01" version="1">MVARRPSEEQCEEQYELYSSSDGMYGDMINDTHWSGLIGDLLNKSFDFAAAAITVTKSRSKVVQYLGPFMEEKTSILMVIPTSPWGLFRMLQPFKHDVWLLLATCIILVGCLLYYTNRRSLLSAYNQGIQTERTNDEEVSFSENLWCSIKSFLFQAVSKRGRMITLSVMSPPGLEVYPVASSARTILLSFWLLALLTRTFWQADMTAHLTRKSNKLPINSLEEFAAQDKIRPLLIKGTATYQMFKDPAASEVHRRVYQKYVEQQSNVTSLSQAVKMILNTSQYAVIGGHHALSYATAMHCLELDWVSDDGGNYHLGFAALPGERYAEAVSLYLSKLKETGVIDRLRNKWWFTMNKCGVHETEYHSLGLQRSAGALIILTAFVALSLLSLLVEMAWDRLARTRKTVAESDQRSVVDEKGDYEYQEYEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABW9</accession>
    <name>A0A075ABW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162794.1">
        <property type="nucleotide sequence ID" value="XM_009164530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABW9"/>
    <dbReference type="STRING" id="6198.A0A075ABW9"/>
    <dbReference type="GeneID" id="20314869"/>
    <dbReference type="KEGG" id="ovi:T265_00681"/>
    <dbReference type="CTD" id="20314869"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="284" mass="32808" checksum="00B231C5A83D3052" modified="2014-10-01" version="1">MPGHTDSDRHSKSYHKRSESGSGREHTSTFIKPEPPSEDERRSSGRSHDHRHHSSRGMSKRGSSRSPRGGRLNAPVIIKEEEGRKRRRLHSPVVLPDDDQRRRDDRRAEPDFSRSGLLDQTSRAPVQRQTANFGLSGKLTEDTNTYKGVVIKYNEPPDARKPTEHWRLYQFKGNECLPILHIHRQSGFLIGRDRKIADIPMDHPSISKQHAVLQYRFVRGLVRLYVIDLESANGTYLNNKRIEPRRYYELLQKDVIKFGYSSREYVVMTANLDEDEMGTPEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFA0</accession>
    <name>A0A075AFA0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase A2-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168743.1">
        <property type="nucleotide sequence ID" value="XM_009170479.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AFA0"/>
    <dbReference type="GeneID" id="20319650"/>
    <dbReference type="KEGG" id="ovi:T265_05468"/>
    <dbReference type="CTD" id="20319650"/>
    <dbReference type="OrthoDB" id="6075074at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="3">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="342" mass="39041" checksum="4C97E419AADF07BB" modified="2014-10-01" version="1">MSPTKCKKSYGRWSPPGXVQEIIWSLVTSRPNNRFSGYDDAGDWIQMDLVKNRLSGRRNSLRLYLDERRLLRNCILNPIDVGKPVPPEPDSFSLTRLNITVHEFNIYSVKSILLACRLFHEAKSARRTTQRGKRWLSELGSVISDTLFGLVGTPNTNHCGPKRIALLISRSRQNGQIFNSLAERLHVRNSQTEFDEMRTADNFERKREGWDTVRLPKPREGKSGGRSYVRTTNLSVNTDEDRNKPLGPEKQTDICCRYHDRCSYVIKSGETKWGITNDMKSAMSHCSCDKTFIRCLKKVNTPTAIAVGTGYFSIYQPHCFVFAKGRTDKAVTRPSYSFLNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGH7</accession>
    <name>A0A075AGH7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167535.1">
        <property type="nucleotide sequence ID" value="XM_009169271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGH7"/>
    <dbReference type="GeneID" id="20318698"/>
    <dbReference type="KEGG" id="ovi:T265_04516"/>
    <dbReference type="CTD" id="20318698"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17511" checksum="EAA8D19339568E21" modified="2014-10-01" version="1">MEQASFTFTFPSAFQQMIDPKEPPDDKWDPCDPTCTWLETLQKLGLIDNWNTSYTSKHSIRQFGKKLTARNPRTSISHHFLRCLPTNASEVTLTPSWKAYKMNSTLTLHNIFQISAYPSSTRIGNNLNSRIPKTFPGSSHYLINGEVGQERKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGS1</accession>
    <name>A0A075AGS1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER29004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167282.1">
        <property type="nucleotide sequence ID" value="XM_009169018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGS1"/>
    <dbReference type="STRING" id="6198.A0A075AGS1"/>
    <dbReference type="GeneID" id="20327636"/>
    <dbReference type="KEGG" id="ovi:T265_13469"/>
    <dbReference type="CTD" id="20327636"/>
    <dbReference type="OrthoDB" id="6088000at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027902">
        <property type="entry name" value="DUF4487"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071:SF2">
        <property type="entry name" value="FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14868">
        <property type="entry name" value="DUF4487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="463" mass="52102" checksum="56515B6D7D5733A7" modified="2014-10-01" version="1">MLNLLCRIATFCIKEFAAISLQATVGRTSSSLLTWITWMVSTRYAGGPNPSGSGLSAELVKHLETSMYLSTDVLLAHMSTVPPPTKQRETECSSAALWLRSATIQPTVRLRVYAGILLNLPKNPHFYSRWVGEEFNIYSEFFTTCAQINTEIPINDESNADTVGDSLTALATEFYTSLLKQVCASICALPAGCYHYLEQALLRGLLVNHPWTNLFVADVWCFLARYGPGELCWHYVNLFASAIQQMAVRSSSDAGTLSERVAMRLDRLGRVLARFLVFLTPKQQSQFFERYPLREAALPNLLDPATEHQAPLIWRFVPLTLSRLQKPAQTMLEEQLDQRLIGLVRTVERHSLKKDWDIELTVETMKTIASAFACVSPDSASPVCRPLLANLKQVLSQVSCEHPMDVEDEGVLRCIRQVDDALNQLECKWKSDCSHSSVNMDAVRKLNHRFHTFLRNLDVTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIB0</accession>
    <name>A0A075AIB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosomal protein of 85 kDa-like CC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164874.1">
        <property type="nucleotide sequence ID" value="XM_009166610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIB0"/>
    <dbReference type="STRING" id="6198.A0A075AIB0"/>
    <dbReference type="GeneID" id="20316565"/>
    <dbReference type="KEGG" id="ovi:T265_02377"/>
    <dbReference type="CTD" id="20316565"/>
    <dbReference type="OrthoDB" id="6251287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058190">
        <property type="entry name" value="CC4_CEP85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040210">
        <property type="entry name" value="Cep85/Cep85L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31075">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 85 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31075:SF4">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 85 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24555">
        <property type="entry name" value="CC4_CEP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein of 85 kDa-like CC4 coiled-coil" evidence="2">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="439" mass="50202" checksum="A62B20B7FB74A58D" modified="2014-10-01" version="1">MEYDGRATEVELLQQRVNELTWLLNERQKNANLELGSVEYELEQYKEAHAKVCADYEAKLGAAVKENECLQHQLAEAQNSLESYRLTVRDKTERLKQLESYLAQLPTTEEHSEMAKQLSVAQQRTTDLEKQTDKTKDELERLESRLAETMAKLRRSHEREELLQTQLDCAMQRLQIKTPSNGGNPSVDLGLKSTRVTPEFVEDLRFEVDRYRTAFEQAKKLLEAETHRAEGLAARQKMEKRQFEEQLAREEATVAGLKATLSSRKSEINQLKEYISKLNAEKQDLLDRLLCTHSSLSKAVEAWRSTGGRRRIRFLHDLKASVREAVCLSDHLCRLASGEKLDLSSLLFQPQTPADCYPSLRENEETKLSPTDRKPSECNKDLPTNPCLLPTIDIDFDDSLADEDIHCVQDAKQTLIGLRQKLADRYADHLGGKIDCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIG3</accession>
    <name>A0A075AIG3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of microtubule dynamics protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein FAM82B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164711.1">
        <property type="nucleotide sequence ID" value="XM_009166447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIG3"/>
    <dbReference type="STRING" id="6198.A0A075AIG3"/>
    <dbReference type="GeneID" id="20327126"/>
    <dbReference type="KEGG" id="ovi:T265_12958"/>
    <dbReference type="CTD" id="20327126"/>
    <dbReference type="OrthoDB" id="512473at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="265" mass="30750" checksum="3270A31ECB77E055" modified="2014-10-01" version="1" fragment="single">MEELYEKADALFELENYTDCYNLLVDIEECHQVADVYWRLARCLYYKNHSEEKRPSKSQLKLVLTDIHRYAKTGVELDPKNSNCCVWYGIGVDELAGLDGVHERLKHSPVSHYYWTKAIELDPNNFLAHSELGIWYFIVSDVSEVIRKFETVFYTSPPIATYEESLASLLRCEELCPRHLIRNMLYLAKCYKALGQYDESLAFCKLVIEYQGSGYDVEELLLLVSRTTHTASTSKRRKPFSANSSVSRQRLKQLQAIGQNESHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIP6</accession>
    <name>A0A075AIP6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164316.1">
        <property type="nucleotide sequence ID" value="XM_009166052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIP6"/>
    <dbReference type="GeneID" id="20316114"/>
    <dbReference type="KEGG" id="ovi:T265_01926"/>
    <dbReference type="CTD" id="20316114"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12563" checksum="716FD6153ACEEFFE" modified="2014-10-01" version="1">MQISALANTLPHAESIKSSSTPFFHYIELSLKDLGNDEFVSLVECSVCLRVCSIVVYFKFDACSSGFYRSAVTPFRCLAAMLPEGSTRSGILPGCPSLDRGVGRQRSGSNHGPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ61</accession>
    <name>A0A075AJ61_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163346.1">
        <property type="nucleotide sequence ID" value="XM_009165082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ61"/>
    <dbReference type="GeneID" id="20315309"/>
    <dbReference type="KEGG" id="ovi:T265_01121"/>
    <dbReference type="CTD" id="20315309"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="347" mass="38310" checksum="D45BD111163E51D7" modified="2014-10-01" version="1">MMASDDAVENPFNDPVERLTTVMPINLISFHFFQQIPSEATASVNSRIQTGALGDYNPFERDTSTLTGTIASNPDFPPPYSSLEAQRLTTTELERRQKELDAKAAELARREAEQNRLAEQVRQGSQGPIKNWPPLPSFFPCGPCFYQDIDLEINSEYRRIVRFGYYLWVAYAGLLLINFFGALLYFAGTGRSDGGSLFGVSIIVCIFCIPASFICWFRPLYKAFRSDSSINFFIFFIVFGAQILVLIIQSLGILNWGSCGWITGLAAVKDTPAIGGITLAIACVFTGMAVACAFYLIRVHRIYRNTGASFGKAREEFTRGVSSNPTVQSAAVETGLFAVRNAGIGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJA7</accession>
    <name>A0A075AJA7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_00957</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163136.1">
        <property type="nucleotide sequence ID" value="XM_009164872.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJA7"/>
    <dbReference type="GeneID" id="20315145"/>
    <dbReference type="KEGG" id="ovi:T265_00957"/>
    <dbReference type="CTD" id="20315145"/>
    <dbReference type="OrthoDB" id="5815793at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027008">
        <property type="entry name" value="Teashirt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487:SF7">
        <property type="entry name" value="PROTEIN TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487">
        <property type="entry name" value="TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="753"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="972"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1295"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1481"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1658"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="805"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="972"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1383"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1481"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1498"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1742" mass="184898" checksum="849A303D790601B9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJD0</accession>
    <name>A0A075AJD0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163027.1">
        <property type="nucleotide sequence ID" value="XM_009164763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJD0"/>
    <dbReference type="STRING" id="6198.A0A075AJD0"/>
    <dbReference type="GeneID" id="20315056"/>
    <dbReference type="KEGG" id="ovi:T265_00868"/>
    <dbReference type="CTD" id="20315056"/>
    <dbReference type="OrthoDB" id="6232933at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="16696" checksum="E88ACCE6C86669CC" modified="2014-10-01" version="1">MPKCISLLKRHRAAGPDELPPGLFKDGGELLAIHYVSRNGSQFTCPVGSYFQCMASQSSKLTKPSSVKDPIVQPEVFVTLSDLKAEAFRSGNTPTFVGSMRECSADYVPNKVVPIVVGVALAAMIIIALITSSSGGKVFSAKAYSLDQLEGTDVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUQ6</accession>
    <name>A0A074YUQ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601322">
        <property type="protein sequence ID" value="KER18438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177815.1">
        <property type="nucleotide sequence ID" value="XM_009179551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUQ6"/>
    <dbReference type="GeneID" id="20330221"/>
    <dbReference type="KEGG" id="ovi:T265_16056"/>
    <dbReference type="CTD" id="20330221"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6875" checksum="10C043EDFD765763" modified="2014-10-01" version="1" fragment="single">LAGLKGYSKGLVDEVSFASLTSFQQFARKRRSRIQINPENLRIIALKQAHVGEKLKRKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVP3</accession>
    <name>A0A074YVP3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598275">
        <property type="protein sequence ID" value="KER18733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177520.1">
        <property type="nucleotide sequence ID" value="XM_009179256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVP3"/>
    <dbReference type="STRING" id="6198.A0A074YVP3"/>
    <dbReference type="GeneID" id="20330025"/>
    <dbReference type="KEGG" id="ovi:T265_15860"/>
    <dbReference type="CTD" id="20330025"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6995" checksum="AEBC2C549F219AEC" modified="2014-10-01" version="1" fragment="single">MVLKQSRHSEMSSVIKSRLKLYRENSSDTPTTAPKKVDPRAEIMLARQLSQVSCDDTDNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXC4</accession>
    <name>A0A074YXC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597205">
        <property type="protein sequence ID" value="KER19451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176807.1">
        <property type="nucleotide sequence ID" value="XM_009178543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXC4"/>
    <dbReference type="GeneID" id="20325951"/>
    <dbReference type="KEGG" id="ovi:T265_11783"/>
    <dbReference type="CTD" id="20325951"/>
    <dbReference type="OrthoDB" id="6243591at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27020" checksum="1DD35856B5D61269" modified="2014-10-01" version="1">MVNGQLTTPDDLCAPPSTPALVWTQEVARKSGQVSFDLSNNLCYEYERSDIPTAQGERIIGYVSSTGDAPGEGISQTLNGRKCLRLRREREAVWHVENPYYEGISTANRKPGHSVSQHGQNRATLLIGYSSNLYPSRFASQMPVVNEIPARIFRFEPRSQLSCQENSPLVLQSEKPGWKKREYHYSSSPTLPTSDISPSRPFGLRHDLKFYKGATFERPKSQNRRSLFQIIRAGSDQPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZQ3</accession>
    <name>A0A074YZQ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598754">
        <property type="protein sequence ID" value="KER18677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177576.1">
        <property type="nucleotide sequence ID" value="XM_009179312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZQ3"/>
    <dbReference type="GeneID" id="20330062"/>
    <dbReference type="KEGG" id="ovi:T265_15897"/>
    <dbReference type="CTD" id="20330062"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="7970" checksum="5B5620AEC711BF4A" modified="2014-10-01" version="1" fragment="single">GDSGLKPTEPVEHNLKHRFPVHEIPVFLALDGVLMKDTGAPASAEEVREVIRRCLEQAALVNYTRISEYAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z130</accession>
    <name>A0A074Z130_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597035">
        <property type="protein sequence ID" value="KER20648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175607.1">
        <property type="nucleotide sequence ID" value="XM_009177343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z130"/>
    <dbReference type="STRING" id="6198.A0A074Z130"/>
    <dbReference type="GeneID" id="20325024"/>
    <dbReference type="KEGG" id="ovi:T265_10856"/>
    <dbReference type="CTD" id="20325024"/>
    <dbReference type="OrthoDB" id="428774at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="573" mass="65994" checksum="A3C81BBFB8915414" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1S7</accession>
    <name>A0A074Z1S7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597205">
        <property type="protein sequence ID" value="KER19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176803.1">
        <property type="nucleotide sequence ID" value="XM_009178539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1S7"/>
    <dbReference type="STRING" id="6198.A0A074Z1S7"/>
    <dbReference type="GeneID" id="20329704"/>
    <dbReference type="KEGG" id="ovi:T265_15539"/>
    <dbReference type="CTD" id="20329704"/>
    <dbReference type="OrthoDB" id="10420311at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="447" mass="49658" checksum="6D11111006C67C09" modified="2014-10-01" version="1" fragment="single">MKRCAGNPSTSRPLGTTSEATALPDLLSPDVEEQVSLPPKAAVNASTIRLGKLWRSKILRAVTNRLLPQESQPITHASVRDADTFERFAKIGNPRLELERPNQSQEPTSWSLSPQKGTTNTNYLDKTENVRQTETKHVSILVDKSRGTANQSARELRQNQPETKLLRQQRIKQAKPITRTIPLAENESSLIEDTPESVDIPVDTHLFVGATEEKLDDLKEPQPDPLGPTPLAYSRAASVPRDRVRRTLEWSTCRQKSLPNASTAQHSNSTFGAKPLEAQSYSRTAQAETPQESELESEGLYDPGLVSSRMRSRHSPTSCGLENRVKKAIEHEVWAEPFAEPLHAPKLESRHTQDSGYLSMDPSDRSFSIRTLSHSLSHQVSVQVDKGSSPRRESVPVSRQEEFSKQPLPEKQSVVDVAPKSTLPMLAVLSSNEEPKLSPPDPKRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z238</accession>
    <name>A0A074Z238_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596993">
        <property type="protein sequence ID" value="KER21116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175143.1">
        <property type="nucleotide sequence ID" value="XM_009176879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z238"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20329329"/>
    <dbReference type="KEGG" id="ovi:T265_15164"/>
    <dbReference type="CTD" id="20329329"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39630" checksum="8002506268FC4A4C" modified="2014-10-01" version="1" fragment="single">PLVFFLSDQRVNFSQKTLCHFSFFHSRNPFKGEVFHDYVHEDIYQGVKIDYRGKDVTRDNFVKVLKGDEKLAANKKKVLKSGPDDNVFIFYSGHGGVSFITLLEEEFMLLSLGHRHLTRMFVLLLRQLHAVELNGILAHMHSKKKYNKMVLYVGACFSGSLFRNILPRNVGIYVTTSAKENEKSWSIHCDDIDIDACLASEYAYAWISDSEYHDLKRRTLDQQYEEVKKRLADSHAMKYGEMAIGNLPVGKFQGHYNLPMQRNDGTILRNAVHRKPSLQAHLFSKSRRIMEATREQDQEAAWRKLRRAIQVREVAHHTPHLMALCKAGYMAQTLIDSVYNVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2T5</accession>
    <name>A0A074Z2T5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FMRFamide-activated amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596978">
        <property type="protein sequence ID" value="KER21293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174963.1">
        <property type="nucleotide sequence ID" value="XM_009176699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2T5"/>
    <dbReference type="STRING" id="6198.A0A074Z2T5"/>
    <dbReference type="GeneID" id="20324522"/>
    <dbReference type="KEGG" id="ovi:T265_10354"/>
    <dbReference type="CTD" id="20324522"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33451" checksum="001181D2945EB8BE" modified="2014-10-01" version="1">MGSFVHEGSCDVQSLQGARSKDTNSTKIGSLKSECLAELELVKNHVTCKSDVTRHFEGDVVPSCTLPCQFFSYETDRSTSTWPTKSWQLGWLGTRAGRMILDRPELASYREARDLMQQPNGDVRAQTLLSQTNVLEKNLLAIMIIRPNFNLHNVEEKEVLSLTSLLSQTGGLLSIWIGMNIMSVIELFELLVHLFGTCKQPENRKNMNKDSSHQSRVVRNEQEETEDGMHIADNLYNGNEERISQNSIIQHPKNNSNNASNRRLNKRRTKCLKRTTCQRARPSSTNLECSERSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3S9</accession>
    <name>A0A074Z3S9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596944">
        <property type="protein sequence ID" value="KER21736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174520.1">
        <property type="nucleotide sequence ID" value="XM_009176256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3S9"/>
    <dbReference type="GeneID" id="20329189"/>
    <dbReference type="KEGG" id="ovi:T265_15023"/>
    <dbReference type="CTD" id="20329189"/>
    <dbReference type="OrthoDB" id="6252720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704898" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10714" checksum="96A6FDB07C77D2C1" modified="2014-10-01" version="1" fragment="single">MRLPLVIALLALMTVTLGHMTEVDLKRAHQLGKSRHMQVDEDASPMEFLHSVATRMQKIRVPLREKICQWSKESEVGQKFRAARKAMREAIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z476</accession>
    <name>A0A074Z476_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_09878</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="KL596933">
        <property type="protein sequence ID" value="KER21896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174349.1">
        <property type="nucleotide sequence ID" value="XM_009176085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z476"/>
    <dbReference type="STRING" id="6198.A0A074Z476"/>
    <dbReference type="GeneID" id="20324046"/>
    <dbReference type="KEGG" id="ovi:T265_09878"/>
    <dbReference type="CTD" id="20324046"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="15">
        <location>
            <begin position="59"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="16">
        <location>
            <begin position="429"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER21896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="570" mass="62911" checksum="B4096EDF662ED88D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4B4</accession>
    <name>A0A074Z4B4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596933">
        <property type="protein sequence ID" value="KER21898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174351.1">
        <property type="nucleotide sequence ID" value="XM_009176087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4B4"/>
    <dbReference type="STRING" id="6198.A0A074Z4B4"/>
    <dbReference type="GeneID" id="20324048"/>
    <dbReference type="KEGG" id="ovi:T265_09880"/>
    <dbReference type="CTD" id="20324048"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="548" mass="60005" checksum="9833D63387A45F48" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z504</accession>
    <name>A0A074Z504_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CD36 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174096.1">
        <property type="nucleotide sequence ID" value="XM_009175832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z504"/>
    <dbReference type="GeneID" id="20323845"/>
    <dbReference type="KEGG" id="ovi:T265_09677"/>
    <dbReference type="CTD" id="20323845"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="949"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116350" checksum="59F8CABEF7FA5200" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z637</accession>
    <name>A0A074Z637_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Musashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596889">
        <property type="protein sequence ID" value="KER22606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173644.1">
        <property type="nucleotide sequence ID" value="XM_009175380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z637"/>
    <dbReference type="STRING" id="6198.A0A074Z637"/>
    <dbReference type="GeneID" id="20323514"/>
    <dbReference type="KEGG" id="ovi:T265_09341"/>
    <dbReference type="CTD" id="20323514"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12576">
        <property type="entry name" value="RRM1_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12323">
        <property type="entry name" value="RRM2_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034126">
        <property type="entry name" value="MSI_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="79"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="388" mass="41968" checksum="D886BCE7DD121E43" modified="2014-10-01" version="1">MEMTVSQLKPSSSPSDDSAVGDMNSNGNSTVDSTNGEATCSDSTVSAGECLSDTYTKLSLTKRQASLGMENGVDSNDPGKMFIGGLSPTTTADKLREYFQRFGEVKECMIMRDPLTKRSRGFGFVTFCDSVCVEKVLESAPHFLDSKKIDPKLAVPRKPGQNAKLTTRTKRVFIGGVATQTTNEELSEYFSQYGKIESCELMMDKTTNRHRGFGFVTFESEETAEKVCEIHFHDLHNKMVEAKKAVPKEVMSSSNSLLKQRSPFLRPQLPSFLPVSLNGAAAAAATYTLTATSPVTARQPSATYAYLPGYYLSPASFLPVSLNGAAAAAATYTLTATSPVTARQPSATYAYLPGYYLSPGECPLSQPLSVFLPPPALLPPYTNMISMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z649</accession>
    <name>A0A074Z649_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596892">
        <property type="protein sequence ID" value="KER22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173691.1">
        <property type="nucleotide sequence ID" value="XM_009175427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z649"/>
    <dbReference type="STRING" id="6198.A0A074Z649"/>
    <dbReference type="GeneID" id="20323552"/>
    <dbReference type="KEGG" id="ovi:T265_09383"/>
    <dbReference type="CTD" id="20323552"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29383" checksum="2A2AC790727C941D" modified="2014-10-01" version="1">MSSAQVPENLKSVVKFLKCAEQHDTRDVVVAYFCRLCAFQKGYALDASSPNSKAFLTKLMCKLEEMKASNAANEAFSSETVGLAHLEEHAIKLFQFAYNRDVNADFTNVLHRATVQSFLTAGVLLDVATTLGQPTDELEKMRKYAKWKTLYITNCQKNGEVPIPGPAAASQDSELDIDFDFKVPGGLPTAKTPQAPPVANQPKPVVDPVVPVPSNPDTRSSVDNTNQIDSEVYVAVEKQIRFALSALQYQDKKSVVDNLTKALKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6B0</accession>
    <name>A0A074Z6B0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596995">
        <property type="protein sequence ID" value="KER21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175163.1">
        <property type="nucleotide sequence ID" value="XM_009176899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6B0"/>
    <dbReference type="GeneID" id="20324679"/>
    <dbReference type="KEGG" id="ovi:T265_10511"/>
    <dbReference type="CTD" id="20324679"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="13841" checksum="681A8167C7FA0871" modified="2014-10-01" version="1">MSVKRIQVENGCKIALLIPSTASRLLLSTLGQPDSITALVSPPDGRAAAHRNCCSRTIVIIIRGTWGPAGHIRKAPPTGTTGPWGGTLTKYQRPAPDEGRRHQVETPGKRRIGPWGPIPGMVEHGRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6D0</accession>
    <name>A0A074Z6D0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597900">
        <property type="protein sequence ID" value="KER18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177451.1">
        <property type="nucleotide sequence ID" value="XM_009179187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6D0"/>
    <dbReference type="STRING" id="6198.A0A074Z6D0"/>
    <dbReference type="GeneID" id="20326316"/>
    <dbReference type="KEGG" id="ovi:T265_12148"/>
    <dbReference type="CTD" id="20326316"/>
    <dbReference type="OrthoDB" id="6286681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14067" checksum="9097829D415E6241" modified="2014-10-01" version="1">MTEPIIPVGRTFCKPDLVVRHGEHAYVLDVTVVRGQRLAEGWTLKTTKYGLSEVESYIQSELFGRSLGDVRHLPVVFTDRGLLCERSGKGLGSLGLIAKELSVLCLLVTRGSLACYDVYMRGTQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8T7</accession>
    <name>A0A074Z8T7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER21997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174236.1">
        <property type="nucleotide sequence ID" value="XM_009175972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8T7"/>
    <dbReference type="STRING" id="6198.A0A074Z8T7"/>
    <dbReference type="GeneID" id="20323963"/>
    <dbReference type="KEGG" id="ovi:T265_09795"/>
    <dbReference type="CTD" id="20323963"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="33656" checksum="C22B868DEF93FFDB" modified="2014-10-01" version="1">MARAYVVADRRGNVCTIKDGRGSKRVNRTQLRKWHDTPEQQPNRLAAKADLTELSLTPLTNLDWRAVLGALGLALPLSMLFYMEQNIASAIVNSPANRLRKSPAPHWDLMVVALINMVLSIFCLPWVHAALPHSPLHIRALADIEERIDMGQHIRQTSTLSQSIYLSCSIVRVRETRLTTIISHIFIGLSLLMIPIPLCYIPPAVLMGLFVYMAVTAVYSNQLFERLLLFITEQSAYPPSHYIRRVPQRKLHLFTIIQLIQLLVLCAFGFAPNPYVEMVFPVLLVGQIVFRYVTPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W2</accession>
    <name>A0A074Z8W2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597162">
        <property type="protein sequence ID" value="KER19645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176601.1">
        <property type="nucleotide sequence ID" value="XM_009178337.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z8W2"/>
    <dbReference type="GeneID" id="20325800"/>
    <dbReference type="KEGG" id="ovi:T265_11632"/>
    <dbReference type="CTD" id="20325800"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1264"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1279"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1305" mass="147270" checksum="C6E6140C8C50D0EE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z985</accession>
    <name>A0A074Z985_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_15457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597138">
        <property type="protein sequence ID" value="KER19800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176460.1">
        <property type="nucleotide sequence ID" value="XM_009178196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z985"/>
    <dbReference type="STRING" id="6198.A0A074Z985"/>
    <dbReference type="GeneID" id="20329622"/>
    <dbReference type="KEGG" id="ovi:T265_15457"/>
    <dbReference type="CTD" id="20329622"/>
    <dbReference type="OrthoDB" id="6137041at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="17432" checksum="B1838EB6EB768F22" modified="2014-10-01" version="1">MYWSVFVLSFKTGRYIKQHMKRFINFCYQSKPSSKHVHESHDRGIPCSKCGKCFTNWSKLCRHQRDVHRNENQLQCHECGVLFSQKSNLDRHMRTKHETQVPHICEQCGKMYARQDMPRKHVKTTHVKDPILHLQMAEHSISLALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z992</accession>
    <name>A0A074Z992_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174132.1">
        <property type="nucleotide sequence ID" value="XM_009175868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z992"/>
    <dbReference type="GeneID" id="20329104"/>
    <dbReference type="KEGG" id="ovi:T265_14938"/>
    <dbReference type="CTD" id="20329104"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9226" checksum="5C284684FE462BB2" modified="2014-10-01" version="1" fragment="single">MLDEENSEDELNAASIGLFLSGRVLKGRFLHHMRSSGESCILPGRRKLQNMYPEPTCKPFMIAIDDGQLAQADKAAVVKPMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9M2</accession>
    <name>A0A074Z9M2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173971.1">
        <property type="nucleotide sequence ID" value="XM_009175707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9M2"/>
    <dbReference type="STRING" id="6198.A0A074Z9M2"/>
    <dbReference type="GeneID" id="20323760"/>
    <dbReference type="KEGG" id="ovi:T265_09592"/>
    <dbReference type="CTD" id="20323760"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="609" mass="66577" checksum="756D9F9B4C70A265" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9Q9</accession>
    <name>A0A074Z9Q9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596832">
        <property type="protein sequence ID" value="KER23853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172396.1">
        <property type="nucleotide sequence ID" value="XM_009174132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9Q9"/>
    <dbReference type="GeneID" id="20322535"/>
    <dbReference type="KEGG" id="ovi:T265_08356"/>
    <dbReference type="CTD" id="20322535"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9922" checksum="3535B10AEC982393" modified="2014-10-01" version="1">MYKLVNYLATKLDLTSLQIEGLDRSREIVSLGDEFDPRDGIVADTLCEFQDTSLADEAVFYEIQVGPARWIRHTSLIRPTDAHILPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9V2</accession>
    <name>A0A074Z9V2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_11340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597104">
        <property type="protein sequence ID" value="KER20020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176235.1">
        <property type="nucleotide sequence ID" value="XM_009177971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9V2"/>
    <dbReference type="STRING" id="6198.A0A074Z9V2"/>
    <dbReference type="GeneID" id="20325508"/>
    <dbReference type="KEGG" id="ovi:T265_11340"/>
    <dbReference type="CTD" id="20325508"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15573" checksum="64F96C62C0DB7316" modified="2014-10-01" version="1">MDTSGSGLNLNSLTSAQKEQLMEQMKAEVALASAQELLQRMSDKCFEKCVPKPGVSLDNSEQKEQLMEQMKAEVALASAQELLQRMSDKCFEKCVPKPGVSLDNSEQKCVGMCMDRYVDAWNLVSRTFAARVRREAEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA17</accession>
    <name>A0A074ZA17_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172150.1">
        <property type="nucleotide sequence ID" value="XM_009173886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA17"/>
    <dbReference type="GeneID" id="20328654"/>
    <dbReference type="KEGG" id="ovi:T265_14488"/>
    <dbReference type="CTD" id="20328654"/>
    <dbReference type="OrthoDB" id="6252808at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="36277" checksum="D2753F9E00AA027D" modified="2014-10-01" version="1" fragment="single">MIEGVCPMGAARSKPLIPRSSRMMALRKFKNFGRDLADPRPNTSSAQPVKTSKGTAPILRLPNDAENTVRKVGETYLASGDTDQLRVKRNKFQQGLAANSFELNSINHPALIENPHTILKTRSTDSAKEILLSVPGRLAPLTKRRSTPGEELPLDSRIRRVSMILMSRHTLPYTDSRIQIVEPKSSMGSGNSLKDDTALNPALSTSSRGWKYNGVVRQDTDNWSLLSAPKGESPTSLPKRSPEVTFPQMASLDSCAGRREITLRKNKKARRPTDRFSKGIGYHLGRRRHLLERRRRMADFALAFGIFGILAALLDTESIACGWYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAH5</accession>
    <name>A0A074ZAH5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597078">
        <property type="protein sequence ID" value="KER20215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176042.1">
        <property type="nucleotide sequence ID" value="XM_009177778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAH5"/>
    <dbReference type="GeneID" id="20325353"/>
    <dbReference type="KEGG" id="ovi:T265_11185"/>
    <dbReference type="CTD" id="20325353"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="17670" checksum="9AC4C8460B87A5D0" modified="2014-10-01" version="1">MNKRAKRVVGMGRLEVAVTDLSPLRQFMAWHCVLLPANNIHRSPAHRTDDSVRHASVLREASTRHMVPTSSGISNSVLKPRHPLYLAALNVRTLKQAGQQAALALTLDSLGYDGTCCEEDSGKCLSRHPYLPTILLQDFVKSFPDSIGANISLALPITTFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBG5</accession>
    <name>A0A074ZBG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171748.1">
        <property type="nucleotide sequence ID" value="XM_009173484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBG5"/>
    <dbReference type="STRING" id="6198.A0A074ZBG5"/>
    <dbReference type="GeneID" id="20322023"/>
    <dbReference type="KEGG" id="ovi:T265_07844"/>
    <dbReference type="CTD" id="20322023"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="110250" checksum="5C869DB0698BE38E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC28</accession>
    <name>A0A074ZC28_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171419.1">
        <property type="nucleotide sequence ID" value="XM_009173155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC28"/>
    <dbReference type="STRING" id="6198.A0A074ZC28"/>
    <dbReference type="GeneID" id="20328496"/>
    <dbReference type="KEGG" id="ovi:T265_14330"/>
    <dbReference type="CTD" id="20328496"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF26">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39897" checksum="12E32BB57CAF9172" modified="2014-10-01" version="1" fragment="single">MARRLNLPLSGLAVVLDELRYFFPSLPKDPRTVMKTPRRCCVRQKAGGMYIHLGLKAGLLQQLREIQTTVTNIEIQINVDGIRAYNNSRTQVWPILSRIISPFFGQPFVVGIYCGKQKPNDAHQLMSDTVAELTDVLANGVSGVCSTHTVRLQCIICDSPARAFLKQVKGHTGYYGCDYCTQRGVHIGTRMTFPSLTAPLRRDYDFRTRKQEKHHIGPSPMEELNFPMIDGFPPDYMHSVCLGLVRKFLILLRAMPIGHKARLSLESWNLLNANIEQQSLALSIDFPRKCRGVVDLDRWKASELRQFLLYIGPVVLRDILHPDVYECFMYFSVTTFIGCSPFFHNIMLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCN5</accession>
    <name>A0A074ZCN5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597007">
        <property type="protein sequence ID" value="KER20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175303.1">
        <property type="nucleotide sequence ID" value="XM_009177039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCN5"/>
    <dbReference type="GeneID" id="20324784"/>
    <dbReference type="KEGG" id="ovi:T265_10616"/>
    <dbReference type="CTD" id="20324784"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7709" checksum="FE18B94C93B9601F" modified="2014-10-01" version="1" fragment="single">CVQHQKLRWLGHVLRMPNHRLPKRVLFSMPNSEWARGSMLASARIREVASPKRYIYDLTQESKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCW2</accession>
    <name>A0A074ZCW2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_08643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172773.1">
        <property type="nucleotide sequence ID" value="XM_009174509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCW2"/>
    <dbReference type="STRING" id="6198.A0A074ZCW2"/>
    <dbReference type="GeneID" id="20322822"/>
    <dbReference type="KEGG" id="ovi:T265_08643"/>
    <dbReference type="CTD" id="20322822"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER23477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="91617" checksum="0A29FC49F51D3C68" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGR8</accession>
    <name>A0A074ZGR8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171411.1">
        <property type="nucleotide sequence ID" value="XM_009173147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGR8"/>
    <dbReference type="STRING" id="6198.A0A074ZGR8"/>
    <dbReference type="GeneID" id="20321769"/>
    <dbReference type="KEGG" id="ovi:T265_07590"/>
    <dbReference type="CTD" id="20321769"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="83"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="279" mass="31691" checksum="46C54C7E0EAE339B" modified="2014-10-01" version="1">MHAMEAPGESDSEGGCSRRFLWMENRNKACEPKPRLFVFGEFLDHPCVRNLSHGPHAAFADLLNLFCYGSFETYLAEPTKYPELSSAQIRKLKQLSIIDEAHSRKLIPYESLFKKLDVESSRELEDLIIELFYLDALTGKLDQQRALLEVDSAIGRDVRIEQIPELNATMNTWLDRVESILTHIANEVKLANDRRFEMQLHKKRVQEAAASVKEALRGQLSKTEPDTPRMDIDDHMVHPDLLPDGRGIPTRPSLDCPAGDKDGRNRLGVFKGLRKGAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHD3</accession>
    <name>A0A074ZHD3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169590.1">
        <property type="nucleotide sequence ID" value="XM_009171326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHD3"/>
    <dbReference type="STRING" id="6198.A0A074ZHD3"/>
    <dbReference type="GeneID" id="20320315"/>
    <dbReference type="KEGG" id="ovi:T265_06133"/>
    <dbReference type="CTD" id="20320315"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="313" mass="35580" checksum="6EFBCD7144C7C45C" modified="2014-10-01" version="1">MHGEKGPKNIMRIDAKKDLGIWVSSYLSFTLHHEKSAQKAVAIMRMIRRTFSRITRMDFQILYGAYVGPLLECANQVVYSGRTKDVTLIERVQRAATRMVAGPKSVDYETRLAMLDLFPLEYRRPRGDVIPTYALFEQSLANRFFTVEQANTRRGNTTDRQELNQPGKLGQKRRSCVSIRESVNLGGRLLHLIVLVLRLLDERTNITKLSFTYSFKVFSNAVKYENDTPTNFSKEATSEAIADEVQSRILALASILSRAENIKITDRQGKSDPGNLSKSLDHVYQSMNPIEVEVVCKNHRTNFDNSTSALARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHM3</accession>
    <name>A0A074ZHM3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171006.1">
        <property type="nucleotide sequence ID" value="XM_009172742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHM3"/>
    <dbReference type="STRING" id="6198.A0A074ZHM3"/>
    <dbReference type="GeneID" id="20321443"/>
    <dbReference type="KEGG" id="ovi:T265_07264"/>
    <dbReference type="CTD" id="20321443"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="23666" checksum="A5A6B7B78C1C075B" modified="2014-10-01" version="1">MFIQVQDTPNPNSMKYFPGKDVLGTGTIDFPSIVHTGSSQLARQLFRIEGVERVFFGPDFITITKKDELDWSVIKPEVFGVIMDYYASGLPIISEDTPTDQTDGEVEEDETVMMIKELLDTRIRPTVQEDGGDIIYVGFKDGIVRLKLQGSCSSCPSSVVTLKNGVQNMLQFYIPEVLGVEQVEDELDAVSKKQFEEAENALRSQDTTGHTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP0</accession>
    <name>A0A074ZHP0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171033.1">
        <property type="nucleotide sequence ID" value="XM_009172769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP0"/>
    <dbReference type="STRING" id="6198.A0A074ZHP0"/>
    <dbReference type="GeneID" id="20328418"/>
    <dbReference type="KEGG" id="ovi:T265_14252"/>
    <dbReference type="CTD" id="20328418"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="93557" checksum="C53702F9C0272340" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI07</accession>
    <name>A0A074ZI07_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596872">
        <property type="protein sequence ID" value="KER22930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173306.1">
        <property type="nucleotide sequence ID" value="XM_009175042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI07"/>
    <dbReference type="GeneID" id="20323242"/>
    <dbReference type="KEGG" id="ovi:T265_09063"/>
    <dbReference type="CTD" id="20323242"/>
    <dbReference type="OrthoDB" id="6237184at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="21532" checksum="9C2BA0AE5759CF5A" modified="2014-10-01" version="1">MFSNFLSSLSKQWQVVDEHGDVVDDDETSSIDSDWSFMQLDDGSNLSNRSRSPTGTETSSRSLSRDERHFGFPNSLDSPVRQDPNDRPVSRSARSAQPAVAHPRGATAAALVGADQTTRGVVRPNPVESRQVAARWNAAVHVNGRRSHRTKQNVDAQRAKCLRRGAQVTTGFQRIQVRLMSGGQLPQGRNIAANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIN3</accession>
    <name>A0A074ZIN3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169133.1">
        <property type="nucleotide sequence ID" value="XM_009170869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIN3"/>
    <dbReference type="GeneID" id="20328023"/>
    <dbReference type="KEGG" id="ovi:T265_13856"/>
    <dbReference type="CTD" id="20328023"/>
    <dbReference type="OrthoDB" id="6274754at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="11854" checksum="3702BD578FA49F57" modified="2014-10-01" version="1" fragment="single">VQNANQEVASLSFSGVSRDAHSSPSEEAEAVLKCLYTNCLSLFNKLGDVKQSACLEKLSIIALTETWLTPDVSDAEISIDGERQPLTDKNKTDPGNLGESLDPVYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKF9</accession>
    <name>A0A074ZKF9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169972.1">
        <property type="nucleotide sequence ID" value="XM_009171708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKF9"/>
    <dbReference type="GeneID" id="20320619"/>
    <dbReference type="KEGG" id="ovi:T265_06440"/>
    <dbReference type="CTD" id="20320619"/>
    <dbReference type="OrthoDB" id="6264327at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="20819" checksum="88B8A46E32291E06" modified="2014-10-01" version="1">MEIDVCLDPRTHDSFDSTVSRSHKHKSSICRRFVFAVVHLTHQKLNPTELDTRLNPPTPLQLCFAMRRSIDSSIIDNYGDLSGARILSYDLLLCRKNPATDTHLKTQDLTWSLVLSVPGPHIPQLLSSLSFMTTQGGGDELLGLLLDSTGLSKSDCILYVDVIGVYRTLFELPLDHFVEKKPLKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI5</accession>
    <name>A0A074ZKI5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168407.1">
        <property type="nucleotide sequence ID" value="XM_009170143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI5"/>
    <dbReference type="GeneID" id="20319381"/>
    <dbReference type="KEGG" id="ovi:T265_05199"/>
    <dbReference type="CTD" id="20319381"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="18845" checksum="EB677F04537C933C" modified="2014-10-01" version="1">MRPISSYLFCQCACPPATTHTVESISEMNSYRCWTTVVSTPMESHKSRERYLNRRIKLCPMWLSIIQCLLMLFGHSDLRTRNSANFQRLHYSRDSSVVLVSERICGTESVTTRPHLAFKKAVNCAPEISGLCYRTTMIASNLQCAGDNWSQLIQACPHPNPTCPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLH1</accession>
    <name>A0A074ZLH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="KL596819">
        <property type="protein sequence ID" value="KER24190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172046.1">
        <property type="nucleotide sequence ID" value="XM_009173782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLH1"/>
    <dbReference type="STRING" id="6198.A0A074ZLH1"/>
    <dbReference type="GeneID" id="20322262"/>
    <dbReference type="KEGG" id="ovi:T265_08083"/>
    <dbReference type="CTD" id="20322262"/>
    <dbReference type="OrthoDB" id="6154436at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="5">
        <location>
            <begin position="287"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1135" mass="126597" checksum="BA230EE90D018595" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLY4</accession>
    <name>A0A074ZLY4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167881.1">
        <property type="nucleotide sequence ID" value="XM_009169617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLY4"/>
    <dbReference type="STRING" id="6198.A0A074ZLY4"/>
    <dbReference type="GeneID" id="20327762"/>
    <dbReference type="KEGG" id="ovi:T265_13595"/>
    <dbReference type="CTD" id="20327762"/>
    <dbReference type="OrthoDB" id="5771769at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06958">
        <property type="entry name" value="NR_DBD_COUP_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="256"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="622" mass="70152" checksum="63F0A01E9DB83C1B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLZ6</accession>
    <name>A0A074ZLZ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperone protein DnaK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169495.1">
        <property type="nucleotide sequence ID" value="XM_009171231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLZ6"/>
    <dbReference type="STRING" id="6198.A0A074ZLZ6"/>
    <dbReference type="GeneID" id="20320243"/>
    <dbReference type="KEGG" id="ovi:T265_06061"/>
    <dbReference type="CTD" id="20320243"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71025" checksum="E58AE8667C0A90BA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM21</accession>
    <name>A0A074ZM21_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167838.1">
        <property type="nucleotide sequence ID" value="XM_009169574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM21"/>
    <dbReference type="GeneID" id="20327748"/>
    <dbReference type="KEGG" id="ovi:T265_13581"/>
    <dbReference type="CTD" id="20327748"/>
    <dbReference type="OrthoDB" id="70142at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="482" mass="55068" checksum="AD6B4E6CABA47A76" modified="2014-10-01" version="1" fragment="single">MRMSAIEADDFYRRRFLPGGLPVDRTTTNWSGVHYQFLHLHLMLGVRRTRIVFLLTFVIGCLLWIVFYLHVPQIQSGANLNETPFRLPDWLNNTNALTTNKGFCSSTRQSASSYVVDDTGSYCPRTVLLNSGCCPTPVASDHADTAVIVRRFVCDSCNQARENCCQIYEHCVSCCMNRQHVQLWREALLQAFELPAQRHLLLADGLFQYCQAKCRTSSQVCVLMFEEEEKAQVFLDELTKVIPSFGMHFAPTKCKVMLVDVQSLNTPLTIQGEVLEVVERFTYLGSCISSDCSVTDEVNARICKARAAFANLRHLWRQNGLSLNLKGRVYQATVRAVLLYGCETWPIRAADLRRLQVFDNRCLRTIARVGWCQRIRNEAVRKRVFGCVTGTSIEECVQHQKLRWLGHVLRMPNHRLPKRVLFSMPDSEWRKQRGGQPLTWQRSMKEMTKRLGAVGATRLPGCGPRDPHCAWLETLQDMAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMB5</accession>
    <name>A0A074ZMB5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171724.1">
        <property type="nucleotide sequence ID" value="XM_009173460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMB5"/>
    <dbReference type="STRING" id="6198.A0A074ZMB5"/>
    <dbReference type="GeneID" id="20322006"/>
    <dbReference type="KEGG" id="ovi:T265_07827"/>
    <dbReference type="CTD" id="20322006"/>
    <dbReference type="OrthoDB" id="21006at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025224">
        <property type="entry name" value="CCAR1/CCAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025954">
        <property type="entry name" value="DBC1/CARP1_inactive_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045353">
        <property type="entry name" value="LAIKA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14304:SF11">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14443">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19256">
        <property type="entry name" value="LAIKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01122">
        <property type="entry name" value="DBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="882" mass="100220" checksum="E92474DB9BF2811E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN16</accession>
    <name>A0A074ZN16_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169098.1">
        <property type="nucleotide sequence ID" value="XM_009170834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN16"/>
    <dbReference type="STRING" id="6198.A0A074ZN16"/>
    <dbReference type="GeneID" id="20319936"/>
    <dbReference type="KEGG" id="ovi:T265_05754"/>
    <dbReference type="CTD" id="20319936"/>
    <dbReference type="OrthoDB" id="552574at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="339" mass="40222" checksum="830538E2C5F54C9F" modified="2014-10-01" version="1">MKKKLLRAASELTFYKERVALLQEQLIYQKRNEEKFIKLRAHYKAQLEEVEKLRAKAAKVPGLEKTVRQQEELITRLESFLDRQRSRNVNENFNKRAPDTDPYDVNLLDHLPPTPTPLPETSDAVAATALRNLSSENENLRQTVAELSRTVRNLAQQQQDDHERQRELEDRHREELQSIREQQNRLAEQQFTQNKQMDYVEKQNLRNAVSENEKTELYRMLEAADYRIRNLEDELASRAPRSRIPYSEGTQNPNRPYVYREPPWRNPGQEKPGNRLPPVINQRDKHQNRRFPQEYVRAHASDSGLEQQRRQLQMQPNARRYDSTILDDDWLGDLVTDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNX4</accession>
    <name>A0A074ZNX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167133.1">
        <property type="nucleotide sequence ID" value="XM_009168869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNX4"/>
    <dbReference type="STRING" id="6198.A0A074ZNX4"/>
    <dbReference type="GeneID" id="20318373"/>
    <dbReference type="KEGG" id="ovi:T265_04187"/>
    <dbReference type="CTD" id="20318373"/>
    <dbReference type="OrthoDB" id="10021598at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="40627" checksum="EC17AA3804886676" modified="2014-10-01" version="1">MIQIFGDSDLTSDMEKIENLVHEQAERITKGPETEEHPDMFDNELVSNRTSITSTTFSNFSPRQSLLPKARESSAVRSDRLNLLNMGLGRGRKVQLRLQQTSQIHRSTAANSKRAQNYEGGTFLTDDPMLDDMELTLFPDDSLDYKAQRGVTGVFDYKGDKAYQYEQTGLGVLRDLTSTERYVRFELPLNPVDLEGLDPIEYLVKYCRISDALDIIYSHMYTTLKSAGKDNSEGVIWSIKERLTGVWEPEQSAEFQELTELDKRGEFELHEFKPLLGLAERLYGIKNLKVVCSEIWPLLPGPLERADFYNLKEKLQHVVLHPSLRNLLIRIEQLTRLISDDLLWTNTAKSDGASAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP29</accession>
    <name>A0A074ZP29_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171145.1">
        <property type="nucleotide sequence ID" value="XM_009172881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP29"/>
    <dbReference type="STRING" id="6198.A0A074ZP29"/>
    <dbReference type="GeneID" id="20321556"/>
    <dbReference type="KEGG" id="ovi:T265_07377"/>
    <dbReference type="CTD" id="20321556"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="443"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="702"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="945"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1272" mass="142928" checksum="C36F8DDB17238656" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQC3</accession>
    <name>A0A074ZQC3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 168</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM168 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166938.1">
        <property type="nucleotide sequence ID" value="XM_009168674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQC3"/>
    <dbReference type="GeneID" id="20318225"/>
    <dbReference type="KEGG" id="ovi:T265_04039"/>
    <dbReference type="CTD" id="20318225"/>
    <dbReference type="OrthoDB" id="5967342at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029713">
        <property type="entry name" value="TMEM168"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14437">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14437:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="798" mass="91208" checksum="811C70077350F3D1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQZ5</accession>
    <name>A0A074ZQZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">T265_03627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166426.1">
        <property type="nucleotide sequence ID" value="XM_009168162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQZ5"/>
    <dbReference type="STRING" id="6198.A0A074ZQZ5"/>
    <dbReference type="GeneID" id="20317814"/>
    <dbReference type="KEGG" id="ovi:T265_03627"/>
    <dbReference type="CTD" id="20317814"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="816"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER29833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="844" mass="97467" checksum="946F9999B8843648" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRT5</accession>
    <name>A0A074ZRT5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167730.1">
        <property type="nucleotide sequence ID" value="XM_009169466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRT5"/>
    <dbReference type="GeneID" id="20318857"/>
    <dbReference type="KEGG" id="ovi:T265_04675"/>
    <dbReference type="CTD" id="20318857"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="15392" checksum="0A0830435DCB24F5" modified="2014-10-01" version="1" fragment="single">WRKAPFHLSLQPGSLHTNRLKHLVPFLSALLLMTTIMMVMMIVMRMMMMMMMTMMMMMMITVMTMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMIVRSFCVRVIEAYGHSHAQNSHYRTFTLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT71</accession>
    <name>A0A074ZT71_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167177.1">
        <property type="nucleotide sequence ID" value="XM_009168913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT71"/>
    <dbReference type="GeneID" id="20318406"/>
    <dbReference type="KEGG" id="ovi:T265_04220"/>
    <dbReference type="CTD" id="20318406"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16236" checksum="9760BC8B2F2A66A1" modified="2014-10-01" version="1">MLGVDWNHGLRSQCLTALPPEESTMAGILPGCPSLYKGSREAEVGFEPRTFRSSSRIYLSAYLPHHPEEAQGLRYCHGAQGAVEIPSSDSNQGPSGQLGNKEHNITETTHKIAENSSIAHDRFRPSWGSSGGLSPRVSVNLMFYLDPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU07</accession>
    <name>A0A074ZU07_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169349.1">
        <property type="nucleotide sequence ID" value="XM_009171085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU07"/>
    <dbReference type="STRING" id="6198.A0A074ZU07"/>
    <dbReference type="GeneID" id="20320120"/>
    <dbReference type="KEGG" id="ovi:T265_05938"/>
    <dbReference type="CTD" id="20320120"/>
    <dbReference type="OrthoDB" id="3069995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1044" mass="114096" checksum="E203B161BF0EB4DD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU09</accession>
    <name>A0A074ZU09_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598797">
        <property type="protein sequence ID" value="KER18674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177579.1">
        <property type="nucleotide sequence ID" value="XM_009179315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU09"/>
    <dbReference type="STRING" id="6198.A0A074ZU09"/>
    <dbReference type="GeneID" id="20330065"/>
    <dbReference type="KEGG" id="ovi:T265_15900"/>
    <dbReference type="CTD" id="20330065"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="17163" checksum="FA1337E93487501A" modified="2014-10-01" version="1" fragment="single">MDKAALLSPPETGDEATPQTREFSETTSSHISPSSQLINSDEEVGKPAEDMVTPCFAPTGQELLEEQMAGLIDYSAAASVADLISRWPQARMVTLYRNFRPASFSQSQGGAHVPTPARRSIGGSLGLNIVGGDGSDATFVSQVQPDKPAGLSKRVFVGDRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU29</accession>
    <name>A0A074ZU29_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169369.1">
        <property type="nucleotide sequence ID" value="XM_009171105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU29"/>
    <dbReference type="STRING" id="6198.A0A074ZU29"/>
    <dbReference type="GeneID" id="20320140"/>
    <dbReference type="KEGG" id="ovi:T265_05958"/>
    <dbReference type="CTD" id="20320140"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="26666" checksum="E2631840A4EF956E" modified="2014-10-01" version="1">MLAHSCLSDQDAMSDLLPKDDGSNAVVHCEIESCSQRELVPFICEACGKMFCVKHKQKEVHGCSKLLTATDQARADRQAGLEASSKLDRAPLEAVSRPLYKTAEPPSSAKLKNDRARVTAAKLTFMKAKMSAKPAGRGASSLPSDNRFILRLAPATGLSCSTVDSPISLYFGKKWPLGKLLDYGQEYFGIKSSPGQSLGLMIIEDEIMPNLPAEMRFLELSRTLNEYACEGRVTEGCLLHIVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUM2</accession>
    <name>A0A074ZUM2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_05780</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169138.1">
        <property type="nucleotide sequence ID" value="XM_009170874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUM2"/>
    <dbReference type="STRING" id="6198.A0A074ZUM2"/>
    <dbReference type="GeneID" id="20319962"/>
    <dbReference type="KEGG" id="ovi:T265_05780"/>
    <dbReference type="CTD" id="20319962"/>
    <dbReference type="OrthoDB" id="6251154at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 16" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704345" description="Delta-like protein" evidence="19">
        <location>
            <begin position="25"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="21">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KER27080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="519" mass="57938" checksum="B9CDC4843F88716B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV32</accession>
    <name>A0A074ZV32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009166617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV32"/>
    <dbReference type="GeneID" id="20316572"/>
    <dbReference type="KEGG" id="ovi:T265_02384"/>
    <dbReference type="CTD" id="20316572"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10708" checksum="2CAD663C349B944F" modified="2014-10-01" version="1">MSTEERMNGPPKPLCHALTIRQTQELHITVSAVQQIQVPAITLKLTEKIEWLPPEYCWLINEASKLAVEKIHLVGKVKLSEILVLLTAEVPDTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV43</accession>
    <name>A0A074ZV43_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV43"/>
    <dbReference type="STRING" id="6198.A0A074ZV43"/>
    <dbReference type="GeneID" id="20317897"/>
    <dbReference type="KEGG" id="ovi:T265_03710"/>
    <dbReference type="CTD" id="20317897"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="24487" checksum="4124131D036C1351" modified="2014-10-01" version="1">MAYERVLLKTIKFDLQVSHPYSYLLQFVKRIKGNQEKLKELVQMSWSFINDSLATTLCLQWEPEIVACAVLYLATRMSKYTIEDWEGRQPGLRWWESFVEGMSTEMEDICHKILDLYPADGSVQESTAESNRYGAVSTSTPSTSSTTFTNMPPSSLPNAGTDLAAKRPRTSYPYGHGAPMPQQSVTQRPTSSFTQPPPTVVAADRGAVHPYAARPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVB5</accession>
    <name>A0A074ZVB5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7083 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164855.1">
        <property type="nucleotide sequence ID" value="XM_009166591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20327145"/>
    <dbReference type="KEGG" id="ovi:T265_12977"/>
    <dbReference type="CTD" id="20327145"/>
    <dbReference type="OrthoDB" id="43807at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7083" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1545" mass="172325" checksum="7DB0E7CCFC7E9E23" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW63</accession>
    <name>A0A074ZW63_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164602.1">
        <property type="nucleotide sequence ID" value="XM_009166338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW63"/>
    <dbReference type="STRING" id="6198.A0A074ZW63"/>
    <dbReference type="GeneID" id="20316352"/>
    <dbReference type="KEGG" id="ovi:T265_02164"/>
    <dbReference type="CTD" id="20316352"/>
    <dbReference type="OrthoDB" id="417262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="29352" checksum="1C344731DCB750E2" modified="2014-10-01" version="1">MKFICIPFILTVAFLSSISKILGSNEPSYFSIHTNLSNLILHLNDSAFTFVAVFDSLFPGDKFLEYQEFAKRTNSVNELSVYHMIHNLNVPSVENVFHKFNLTFVDLPYYLLFCREQPNPIVYRGSWKSEDIVRWVASVTGLRLPLPGCIGSLDILAHRARKADTRELNEHILPEIRRLLSMEPHLSSSSAQFYIQAATHLATRGTAYLSTEAARLKRLVDNEVSDEQKAKLKERLNIIIQFMEPSEMRSEQKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWR2</accession>
    <name>A0A074ZWR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_01982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164384.1">
        <property type="nucleotide sequence ID" value="XM_009166120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWR2"/>
    <dbReference type="STRING" id="6198.A0A074ZWR2"/>
    <dbReference type="GeneID" id="20316170"/>
    <dbReference type="KEGG" id="ovi:T265_01982"/>
    <dbReference type="CTD" id="20316170"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="166"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="386" mass="43249" checksum="E3B31C866AE8D7BE" modified="2014-10-01" version="1">MKSELHHVDHEIKMKQAKVKESKSKIKMNKALPYLVANVVELLDVSPQDQEREDGANVDLDSLRKGKCAVIKTSTRQTYFLPVIGLVPAEELKPGDLVGVNKDSYLILEKLPPEFDSRVKAMEVDERPTERYSDIGGLDKQIQELIEAVVLPMTHKDRFEAIGIQPPKGVLLYGPPGTGKTLLARACAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKEPSILFIDELDAIGTKRFDSERAGDREVQRTMLELLNQLDGFQPNHNIKVIAATNRVDILDPALLRSGRLDRKIEFPAPNEEARARIMQIHSRKMNVNKDVNFEELARCTDDFNGAQCKAVCVEAGMIALRRSASEITHEDYMDAILEVQAKKKTNLNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWU3</accession>
    <name>A0A074ZWU3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165903.1">
        <property type="nucleotide sequence ID" value="XM_009167639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWU3"/>
    <dbReference type="GeneID" id="20317407"/>
    <dbReference type="KEGG" id="ovi:T265_03220"/>
    <dbReference type="CTD" id="20317407"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7083" checksum="E90AE54C5B5812E8" modified="2014-10-01" version="1">MATRDLPHSLKMAGCRPSGLGQYRPRIQCPRSIPTPEVSEACRESSGSTSITKRKVERGRGELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXZ0</accession>
    <name>A0A074ZXZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165370.1">
        <property type="nucleotide sequence ID" value="XM_009167106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXZ0"/>
    <dbReference type="GeneID" id="20316969"/>
    <dbReference type="KEGG" id="ovi:T265_02781"/>
    <dbReference type="CTD" id="20316969"/>
    <dbReference type="OrthoDB" id="10448939at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="10443" checksum="F89D8A1F608E0036" modified="2014-10-01" version="1">MKRPTLVNRDRQHYCAEYRTTDNPTHPVVSHLLGIKRAHDIVNNSYNDRYRPYRQQTVESQKIVSNYFTCVGRHELNSEAAMTQLYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYK3</accession>
    <name>A0A074ZYK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597075">
        <property type="protein sequence ID" value="KER20239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176015.1">
        <property type="nucleotide sequence ID" value="XM_009177751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYK3"/>
    <dbReference type="GeneID" id="20329532"/>
    <dbReference type="KEGG" id="ovi:T265_15367"/>
    <dbReference type="CTD" id="20329532"/>
    <dbReference type="OrthoDB" id="6219776at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="318" mass="37049" checksum="F02307C3472DE8F3" modified="2014-10-01" version="1" fragment="single">MCEPADLNSWREVLVLMFYPRARAMAYRNALIKEKAVVHNYKGILVGYTEQIQHFEGDWDDRICVGVLKFANTRLTKLWLESDHPVRQPDFLDQVEILIVPLQKNDMSQKGYPIIEITNLHLSFKDLYETKYLPELDCLVQKFGGVPLIVCQNEPWKWRGVEDPGSISINQWPDWQSYERYCAREETKKLDDMRKTIGNGYKITAELITDIAHTIDELITLHRLRWLGHVLRMPVDRIPRRALFARPCEGWKRARGGQTMTWQRSMKAITSKLSCAGHCRLPGWGPRDGPHQWLETLSDMAQSRPQWRSCIQAIAFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ49</accession>
    <name>A0A074ZZ49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175794.1">
        <property type="nucleotide sequence ID" value="XM_009177530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ49"/>
    <dbReference type="STRING" id="6198.A0A074ZZ49"/>
    <dbReference type="GeneID" id="20329478"/>
    <dbReference type="KEGG" id="ovi:T265_15313"/>
    <dbReference type="CTD" id="20329478"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12680">
        <property type="entry name" value="RRM_THOC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="29545" checksum="CA1ECC188C15ACE9" modified="2014-10-01" version="1" fragment="single">MDLSLDDIIQRNRKQPRGRGRARGANPLRGVRRGGIARRSTGGGARVLPEKWQHDMFQGGRDGRQPSVSNKLHISNLDFGVSNDDINELFREFGAIRRAAVHYDRSGRSLGTAEVVFLNPLSATKARSHYNGVPLDGRPMVIQLVGAASTTESIRPRVTPPRRRVSVPRGRGSFSGRLSGRGRGRGRARRPVVTKEELDAELAAYNAKDASTVIELTAPALSSRFRLRTSGDAEAAAAGYAGVGIVLSERAEASLLDWIPVDSRICAVCLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ80</accession>
    <name>A0A074ZZ80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163534.1">
        <property type="nucleotide sequence ID" value="XM_009165270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ80"/>
    <dbReference type="GeneID" id="20326915"/>
    <dbReference type="KEGG" id="ovi:T265_12747"/>
    <dbReference type="CTD" id="20326915"/>
    <dbReference type="OrthoDB" id="10067653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039161">
        <property type="entry name" value="C19orf47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21359:SF1">
        <property type="entry name" value="DUF5577 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18017">
        <property type="entry name" value="SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="44717" checksum="8507FE741B38873A" modified="2014-10-01" version="1" fragment="single">ISEWIEFFTAAGVPAAVRKTYAQIFVDHRITGALVADLEKEHLKDMGINVIGDIIAILKQCRKVGHEDPAATVPNVTSTTMTSTIQPPSKAENKSPSTVQFSTPSSTTGTVVRRRMTPEVEGKYVVKYPTGTTAKTQRILANMRQRETSSKLPVKNTEPVTDGRIKSNSRSALTSFEESDVEDSDGYRVILSKEASRSSNLKGSVFGRLGAPTEQIEAPPQPSKQTAVVQRLVARSISTSPSVAKKPTPACESRVSSKTSTAGGAPSKLSITRQVIRAPMLNAMPMKARLASKRQITESVFSRLDDSPNPVGVQTAIRYQQPNSRDALGYAGILKRPRLHPPAKSIPQPNSVRSKPVPFTEGVLSSELTSKKLHNQRSVKARLGPRRTESGQTSKTTGPSGLFGKFLTFCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN2</accession>
    <name>A0A074ZZN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167541.1">
        <property type="nucleotide sequence ID" value="XM_009169277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN2"/>
    <dbReference type="STRING" id="6198.A0A074ZZN2"/>
    <dbReference type="GeneID" id="20318704"/>
    <dbReference type="KEGG" id="ovi:T265_04522"/>
    <dbReference type="CTD" id="20318704"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="250"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="46049" checksum="E79671DF9AD3C3B4" modified="2014-10-01" version="1">MASLLKCPQRFTHEEWTFSNNVKYRSAEKEREFSQGLQNECDRYMDEAEKRTDRTLKDVDKKIGNALEPQLNQRITDIKYWKSEVNKKLDDVTAETDALHSAFIRLKKALDATEEPLHLAQQCILTREGRSGIDLVHDDAQKELCKEVEVYKGVQALLQKTLEQTKEQLRLNRKAIYNLKKDAGDKLSAQHIDEYALSLKSTDESLPGLKKEWQHFSHNTIQAGDKQLQNSQQLRSIIDGILQQIASDQKRQVEATNRALKKRITETRDAKGKLEEHLSRVLEEISKMEDMISEINKSIKDKEGALRLAGTRIDLRKVRPNIELCRDAAEYRLIQEVEEITTDVAELRHRLKLAHDSLKALCRRQLDLEEEIQIKAATLFIDEVQCMGMRESLQINAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN5</accession>
    <name>A0A074ZZN5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_04526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167545.1">
        <property type="nucleotide sequence ID" value="XM_009169281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN5"/>
    <dbReference type="STRING" id="6198.A0A074ZZN5"/>
    <dbReference type="GeneID" id="20318708"/>
    <dbReference type="KEGG" id="ovi:T265_04526"/>
    <dbReference type="CTD" id="20318708"/>
    <dbReference type="OrthoDB" id="6240756at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704428" evidence="3">
        <location>
            <begin position="19"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="727" mass="81389" checksum="19ABC11A838C783F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0R8</accession>
    <name>A0A075A0R8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167170.1">
        <property type="nucleotide sequence ID" value="XM_009168906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0R8"/>
    <dbReference type="GeneID" id="20327618"/>
    <dbReference type="KEGG" id="ovi:T265_13451"/>
    <dbReference type="CTD" id="20327618"/>
    <dbReference type="OrthoDB" id="6246734at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="482" mass="53790" checksum="E496AAE527B6A730" modified="2014-10-01" version="1" fragment="single">DSGVFLRSLTAFGANDGVLYSAELQGLREQLASARASAVRQRWRVFAGFALARHLRCKLMNIPVRPKASEPESINAGMRVYRDLQTRNSVFSTNSSTASGHTREMQALRRQLVEQEELTAVVRQAATKEIERLQALLAKESGDHAASVCEMESQYERTIAQLRTDLSHSQQAVSVLSKRYAELKRTCKKLNFQLTDLRARENESLMMMIQVTDKYTFLNGHKQMVLDRLHELETKLAWASSSSSSPNEENADIDRFLAIQSRASGLDIRTRQVEDRLGALENKLEATVHLLEKAFTLLNESNQDAPDFSCPLKPTTVFTDPDGTGIEENKSDCADRSTSSNCCTAVEVELPHLTQPVCSTDEAIHLEQPDSSVSAMDPSESSSEVSSSDSRHDGPKTLFSGPHAPRFCRYQYTTYEREPVPLLNPVVQCRPVFHTFSGASEWVSSSELVCDSSFVKLDERMPQNILGRLQGMKYGSENKVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0S0</accession>
    <name>A0A075A0S0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597002">
        <property type="protein sequence ID" value="KER21009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175232.1">
        <property type="nucleotide sequence ID" value="XM_009176968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0S0"/>
    <dbReference type="STRING" id="6198.A0A075A0S0"/>
    <dbReference type="GeneID" id="20324729"/>
    <dbReference type="KEGG" id="ovi:T265_10561"/>
    <dbReference type="CTD" id="20324729"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="32045" checksum="B77E42D420F24494" modified="2014-10-01" version="1">MRILALASILPRTENIKSSAAPFFHLCFSHEGQPLTDKNKTDPGNLGKRPDPVYQSVKAGLYVMTVHNLPKAGSTISALVDDVRIEGEVLCIDEPKKLVVILQHSLETSSSTGRRDTCDIIFARTEFLKEVKMLKEGPLPSFPELSINKIAERIRKNERTQQEKQKFYRPDVPPEVRNLAEHIEKTLFDVVWSDPNIVVMEHSIISPPYKEDNSVVATAPVSAEGYTVDVTSLFASHLGSHLFSNVHELAHCIKQFERTSGSYYSRQRLRSHLRLKSEPDSSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1D0</accession>
    <name>A0A075A1D0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPR180/TMEM145 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166900.1">
        <property type="nucleotide sequence ID" value="XM_009168636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1D0"/>
    <dbReference type="GeneID" id="20318204"/>
    <dbReference type="KEGG" id="ovi:T265_04018"/>
    <dbReference type="CTD" id="20318204"/>
    <dbReference type="OrthoDB" id="45670at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF43">
        <property type="entry name" value="INTIMAL THICKNESS RELATED RECEPTOR IRP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="2">
        <location>
            <begin position="456"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="707" mass="79522" checksum="FCF62AAD77CE82F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1E6</accession>
    <name>A0A075A1E6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596985">
        <property type="protein sequence ID" value="KER21194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175053.1">
        <property type="nucleotide sequence ID" value="XM_009176789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1E6"/>
    <dbReference type="GeneID" id="20324589"/>
    <dbReference type="KEGG" id="ovi:T265_10421"/>
    <dbReference type="CTD" id="20324589"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="263" mass="29852" checksum="2A2FD56176088D58" modified="2014-10-01" version="1">MTIIRLQNQPLIHCFWGFLTNVLPARVFCPSANRYDVTNTAVLPDNTVDEKRPFDTDDIHSTNVPPYPGVVPTQRTMMSTDAILALERRQAELEARAAELDRREKEQQSRMSAYQAGTPPHNWPPLPSWCPCKPCVRQDFETDIPLDCRWLAKMGYAVWLTYAVVLLLNMGGTLGYFIVGKSSVEGPLFGASILLLLVMPPLGFFGWHRPLYKALRSDSSMNYVLFFIMFAAQTIIILIQCLGIDYLGSWIICQLLCSRPYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Q3</accession>
    <name>A0A075A1Q3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174934.1">
        <property type="nucleotide sequence ID" value="XM_009176670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Q3"/>
    <dbReference type="GeneID" id="20324502"/>
    <dbReference type="KEGG" id="ovi:T265_10334"/>
    <dbReference type="CTD" id="20324502"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16622" checksum="158E015650DAE392" modified="2014-10-01" version="1">MYVCFQDLIPQDQEQSPLTKYTHLQTSLVLRETHLEPITNERFNCIPEQSLASEHAICGHIPYNSRRITGDCGILYIPPTGQYPDSPLKKSLVTRRYSAPAFPVILIVQRVGSVSMALNLCAAALRPAKSQPFMELKTAFTSDFGILSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A282</accession>
    <name>A0A075A282_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_15072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596961">
        <property type="protein sequence ID" value="KER21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174734.1">
        <property type="nucleotide sequence ID" value="XM_009176470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A282"/>
    <dbReference type="STRING" id="6198.A0A075A282"/>
    <dbReference type="GeneID" id="20329238"/>
    <dbReference type="KEGG" id="ovi:T265_15072"/>
    <dbReference type="CTD" id="20329238"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150007">
        <property type="term" value="P:clathrin-dependent synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62377" checksum="A5C51DD9E7F69B1D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Q4</accession>
    <name>A0A075A2Q4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163699.1">
        <property type="nucleotide sequence ID" value="XM_009165435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Q4"/>
    <dbReference type="STRING" id="6198.A0A075A2Q4"/>
    <dbReference type="GeneID" id="20315597"/>
    <dbReference type="KEGG" id="ovi:T265_01409"/>
    <dbReference type="CTD" id="20315597"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="29"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="551" mass="62938" checksum="DC99C769FFBAD2D8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A329</accession>
    <name>A0A075A329_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166232.1">
        <property type="nucleotide sequence ID" value="XM_009167968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A329"/>
    <dbReference type="GeneID" id="20317655"/>
    <dbReference type="KEGG" id="ovi:T265_03468"/>
    <dbReference type="CTD" id="20317655"/>
    <dbReference type="OrthoDB" id="10367308at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27202" checksum="42E0181A869D0968" modified="2014-10-01" version="1">MGWTLCSIQLKNTMNKRFELEFGCRKKTHRREQNSYILDKRVQMYNLLKLFIGGTLSELGSLLTHVVWPWCEAVTCCILRGRCLTLISADSRCLGLIQACDAQPIQHSSESRIPDTCSNPAHQTTSRLVRSISTPAGFQNASSAHLPRSTNHNWIPYVIQSIPPQNGQTYTALWQISSNQSLTKPVAIRLVGVNGTDVKIGSRLGLVSRGIRTSNTIQASLGCSDRGYPIHFWKESMVSNLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3A1</accession>
    <name>A0A075A3A1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162306.1">
        <property type="nucleotide sequence ID" value="XM_009164042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3A1"/>
    <dbReference type="GeneID" id="20314485"/>
    <dbReference type="KEGG" id="ovi:T265_00297"/>
    <dbReference type="CTD" id="20314485"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9408" checksum="3FB9ACD54351F9F7" modified="2014-10-01" version="1">METRCCALILSSTISQLDNRNTPTVAGPAETRSSDSKHPPDGMMPAQIEGARRSSPLCWFHALQDKLHGRRIRDCLKAGIRYDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3F9</accession>
    <name>A0A075A3F9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163520.1">
        <property type="nucleotide sequence ID" value="XM_009165256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3F9"/>
    <dbReference type="STRING" id="6198.A0A075A3F9"/>
    <dbReference type="GeneID" id="20315459"/>
    <dbReference type="KEGG" id="ovi:T265_01271"/>
    <dbReference type="CTD" id="20315459"/>
    <dbReference type="OrthoDB" id="6248307at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="782"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130515" checksum="7DC939C696B6F662" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3U7</accession>
    <name>A0A075A3U7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_03278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165988.1">
        <property type="nucleotide sequence ID" value="XM_009167724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3U7"/>
    <dbReference type="STRING" id="6198.A0A075A3U7"/>
    <dbReference type="GeneID" id="20317465"/>
    <dbReference type="KEGG" id="ovi:T265_03278"/>
    <dbReference type="CTD" id="20317465"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="307"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="442"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59724" checksum="24D90B6985F75A17" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4C4</accession>
    <name>A0A075A4C4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161980.1">
        <property type="nucleotide sequence ID" value="XM_009163716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4C4"/>
    <dbReference type="STRING" id="6198.A0A075A4C4"/>
    <dbReference type="GeneID" id="20314247"/>
    <dbReference type="KEGG" id="ovi:T265_00059"/>
    <dbReference type="CTD" id="20314247"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="423" mass="46678" checksum="2A583D105E7C8824" modified="2014-10-01" version="1">MKQTPKGVQMAADESLLDPLLVFEEKGQMFLVELTKVTPSPRLVACLLIWDTQIIGHIQKSLDFTLFDCAWVPVSTKFVVVGSKPRGTGAIQIYDVTAKDVQLLTESEKSSSFKCCHFGASRLPQRHIATGAFNGRLAIWDLGQSSRLDVPVYGVQAHTEIINAMDAVGGLGIGEGAPEIATGSRDGTVKVWDPRQPKVPVATMEPGAPEGSEDSVLASSRRDCWTVAFGHAYNNQDRCLAAGYDNGDVKLFDLRAMRVRWETNVKNGVCSLQFDRKDIQMNKLVATTLEGKIHVWDMRTQHPKKGFASLTEKTQGSTIWQVRHLPQQRDVFMTLGGNGNLCLWQYHYPAKRQKMVRESGPEGQGDIEVAQGVIGKLSQLQNVTLSSQPVNSLDWCPDKLGLAVCVSFDQTVRLLIVTKLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5J9</accession>
    <name>A0A075A5J9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_12561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162649.1">
        <property type="nucleotide sequence ID" value="XM_009164385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5J9"/>
    <dbReference type="GeneID" id="20326729"/>
    <dbReference type="KEGG" id="ovi:T265_12561"/>
    <dbReference type="CTD" id="20326729"/>
    <dbReference type="OrthoDB" id="6268551at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="353" mass="38692" checksum="6E34C29D22B7C313" modified="2014-10-01" version="1" fragment="single">LGSTHFSLTVIPANQPVLLGQKVILTCQVKGFKRPLDYAVLFKRKDVGISEKCQTYQKNKYHLECEPNNWLQATTYKLYINSVSWADRGDWFCVYAANLTRQHLVVHAPAELKKMAVTSLPFNPLKSENDRITPVDGSPVLAKLSKSSSSSTVSGTPGQPPAQHVGLGTRTNPYDLRPGLGLQLTCETTCGYPEANISWLLLNETASRVGTTIAGPNRIRSETCDLSPSTQDMTTTTSTLNVNCVELGLIGLNEVQCAVTGRQYIDHTPTRHVYVLCPDQFELDGQRALLSGQKKGRQRGERPLQLTNGEVVGIAVGAAIALILLFLGCIILRASRKDSPLPFNPNYFPGQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A692</accession>
    <name>A0A075A692_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165121.1">
        <property type="nucleotide sequence ID" value="XM_009166857.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A692"/>
    <dbReference type="GeneID" id="20316766"/>
    <dbReference type="KEGG" id="ovi:T265_02578"/>
    <dbReference type="CTD" id="20316766"/>
    <dbReference type="OrthoDB" id="6284883at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1157"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1157"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1384" mass="152175" checksum="4AE1BC0291AE0B6E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6B0</accession>
    <name>A0A075A6B0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162339.1">
        <property type="nucleotide sequence ID" value="XM_009164075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6B0"/>
    <dbReference type="STRING" id="6198.A0A075A6B0"/>
    <dbReference type="GeneID" id="20314518"/>
    <dbReference type="KEGG" id="ovi:T265_00330"/>
    <dbReference type="CTD" id="20314518"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="372" mass="41102" checksum="9B17A275AA44F557" modified="2014-10-01" version="1">MAHPVLDMRLDESMPRELILRRHADFLSAYEKNDDCTLDYLKLSGVFWTLTALDLLGELHNIDREAVLNLVVSCQQADGGLSPAPRHDSHLLSTLSGIQILALFGRMDMLNVDGATRFILSLQQPDGSFCGDQWGEIDTRFSFCAIASLHLMGRLDECADSGRLNVEACASYLERCQNLDGGFGTKPGSESHAGQAYCVLGALAILRELRRLDLDRAAWWLAERQLPSGGLNGRPEKKPDVCYSWWTLASLTILGRLAWIDEKKLTHFILASQDSETGGIADRPGDIADPFHTLFGLAGLSLIAHYDNPSSHTCPNGCGKNGDLTTIDEINVEEFVADAISLAKTRLKPINPIFCMPQYVIERMGLRLQMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6H2</accession>
    <name>A0A075A6H2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162401.1">
        <property type="nucleotide sequence ID" value="XM_009164137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6H2"/>
    <dbReference type="STRING" id="6198.A0A075A6H2"/>
    <dbReference type="GeneID" id="20314580"/>
    <dbReference type="KEGG" id="ovi:T265_00392"/>
    <dbReference type="CTD" id="20314580"/>
    <dbReference type="OrthoDB" id="445052at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF26">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53779" checksum="E6F0DD6CC5172EFD" modified="2014-10-01" version="1">MFTDACVPGIDCHSVDAHEKDFVEQNIQTEPYKIVHRGSQSRRVKDFQSQTDEMVLPSQTTSNSEPESAAMIDFLKRAEAVITEELKKSIRSKALRLLQDEVPDRVLVKQIAQLPLEEAAKHELSVTCLSWNSTGAVLGAAYGSLNHADWCAHNGIISLWNAARSQSGSPIQKLDTNSCVTCLAFHPIIPTLLAAGTFTGEILVYNTTAETDCLIAMNGCNEAGHTEGVTQIEWLIDTRATNSGNSDSKRYAVERFLTIGNEGKVICWTIDAHRRSTLRCSKIFGIKIRDQGVVPASPDIPSDKIRHTTNSTHSKRAVSLTSVALCPDQPNRLVIGTDSGGIMLCNLDYPGSAGSLDLSTDLPSPVEFSLRRQNGPICSVDWSKFYRNLVLSCGIGSSLQIHNVLQRDLSVDVDPTRGKFVAAKFSPYFPNVLACTTGTGSVALYSLLGNNDQNDSGEISEMEPKLLFETDIVATMETKCPVPKISLAFNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A736</accession>
    <name>A0A075A736_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161943.1">
        <property type="nucleotide sequence ID" value="XM_009163679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A736"/>
    <dbReference type="STRING" id="6198.A0A075A736"/>
    <dbReference type="GeneID" id="20314210"/>
    <dbReference type="KEGG" id="ovi:T265_00022"/>
    <dbReference type="CTD" id="20314210"/>
    <dbReference type="OrthoDB" id="6240539at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="760" mass="81813" checksum="D55AE09185182CA9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8K6</accession>
    <name>A0A075A8K6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-nucleotidase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164244.1">
        <property type="nucleotide sequence ID" value="XM_009165980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8K6"/>
    <dbReference type="STRING" id="6198.A0A075A8K6"/>
    <dbReference type="GeneID" id="20327046"/>
    <dbReference type="KEGG" id="ovi:T265_12878"/>
    <dbReference type="CTD" id="20327046"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="173"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="462"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81648" checksum="A90EE04928C3A523" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9D6</accession>
    <name>A0A075A9D6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172147.1">
        <property type="nucleotide sequence ID" value="XM_009173883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9D6"/>
    <dbReference type="GeneID" id="20322342"/>
    <dbReference type="KEGG" id="ovi:T265_08163"/>
    <dbReference type="CTD" id="20322342"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="332" mass="37649" checksum="4E8C11A298ACB0B7" modified="2014-10-01" version="1">MCKACLMFHLERCSTSSINERFSRRADEFPVNTKSVFKQAHLVRFSLFKFSENMSLTKRKPGGCVYLINPKIVDQNWLWAIKESSEKSDDNDDDDVDDYDDDDVVDDNDVDDDAGDDDVDDYGDEDEDDGEVDDVDDDDDYDVDDDAYDHKSSNGCRAKCLKSANATWALEIRELTYSVTLQSELMRLPRHVRRSSAPSRRDWVFPWRDGLRTPATLRVLLGYLPTHSLTVYLIAGSSLSKSNYLMANCHSVQDAFVYESYESTHNPCVLAEFAAKSHSLAPFAIAHSTHLNMNLTNQSSAQKIDYFQSDHPCHLLSSLCFDHSILAESCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACS5</accession>
    <name>A0A075ACS5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162493.1">
        <property type="nucleotide sequence ID" value="XM_009164229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACS5"/>
    <dbReference type="STRING" id="6198.A0A075ACS5"/>
    <dbReference type="GeneID" id="20314644"/>
    <dbReference type="KEGG" id="ovi:T265_00456"/>
    <dbReference type="CTD" id="20314644"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="45845" checksum="446DD2E47A53464C" modified="2014-10-01" version="1">MLHSPSLKSDLNVLAVSPTQPMPLDLSQQPDLSSTFNDEELNVDPTVMRPLNLSIHNHLVHHTNRTDGDHWMKTYQVRHHIHQQPHFSKLPLHPPFFRPLNMSSEIETKVPLAPNQWFRLPAPLMIPKPEQLLAYAMNTHRRSCVEFHEKHFWDTAHERKQALTTSESVLCGNTTMTCMNMTTCLHMMQQAISYTRPFPHPAISEKTLLNGATNVVPTRTKRSLQGTTKRHILNVISNGISSSMGGRTASDLRSEKSAPSLDENSELVSHDRNEPARESLPKHIMILKRDRYHCQYCGKLFPRSANLTRHIRTHTGEQPYKCVHCPRSFSISSNLQRHIRNIHQKERPFHCLVCFKRFGQRANLERHIRNHLISMDSSTTENGHQLYPTTGLLERLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACW6</accession>
    <name>A0A075ACW6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162332.1">
        <property type="nucleotide sequence ID" value="XM_009164068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACW6"/>
    <dbReference type="STRING" id="6198.A0A075ACW6"/>
    <dbReference type="GeneID" id="20314511"/>
    <dbReference type="KEGG" id="ovi:T265_00323"/>
    <dbReference type="CTD" id="20314511"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="24392" checksum="57E7D23D5EECB3F3" modified="2014-10-01" version="1">MSMQHPRCLVYAGAMCALGTMTVLSGKIAFNLFSVLAILGYATTVIPRSFTFYLSGVLFLLFGVKMIYDGRSTVGVTSILSAYQMSPTDAQDEYEEVKLQLAQSNSTDLEMGKVDSSQMSSTRETIRYTMKRIFSPILAEAFILTFLAEWGDRSQLTTIVLAATKSVSGVIVGGILGHAVCTGLAVLVGRFVAQRIPVKWLTYIGGATFLLFGIFTFLGDPDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD74</accession>
    <name>A0A075AD74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_06744</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the E(R) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170353.1">
        <property type="nucleotide sequence ID" value="XM_009172089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD74"/>
    <dbReference type="STRING" id="6198.A0A075AD74"/>
    <dbReference type="GeneID" id="20320923"/>
    <dbReference type="KEGG" id="ovi:T265_06744"/>
    <dbReference type="CTD" id="20320923"/>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053973">
        <property type="entry name" value="ERMP1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22248">
        <property type="entry name" value="ERMP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01290">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="176"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1-like C-terminal" evidence="17">
        <location>
            <begin position="726"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER25889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127430" checksum="11DADBA86AA155DF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADE9</accession>
    <name>A0A075ADE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170251.1">
        <property type="nucleotide sequence ID" value="XM_009171987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADE9"/>
    <dbReference type="STRING" id="6198.A0A075ADE9"/>
    <dbReference type="GeneID" id="20328258"/>
    <dbReference type="KEGG" id="ovi:T265_14092"/>
    <dbReference type="CTD" id="20328258"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24145" checksum="CCBAD85565A1CBC8" modified="2014-10-01" version="1" fragment="single">VLLVGDSCVGKTSLLIRFKDRIFLKGTYISTVGIDYKAKVVNANGIPVRLKIWDTAGQEKFRSLTKSYYRDSDGWLCHLHPHYLLFPAVVLVYDISRMETLVHTKSWMDEITANADSKTLLLLAGNKADELRERAVSKRDGERVAKECGALFWETSAKTGQNVDAMFHSVAETLLSSSASESPVDKNGFALPSDKTGPTDSEPSNPTRLSGNTFRCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADF5</accession>
    <name>A0A075ADF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161951.1">
        <property type="nucleotide sequence ID" value="XM_009163687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADF5"/>
    <dbReference type="STRING" id="6198.A0A075ADF5"/>
    <dbReference type="GeneID" id="20314218"/>
    <dbReference type="KEGG" id="ovi:T265_00030"/>
    <dbReference type="CTD" id="20314218"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008726">
        <property type="entry name" value="PRK11728.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="565" mass="62894" checksum="2EC2DBA0061C3EC9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADL3</accession>
    <name>A0A075ADL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170165.1">
        <property type="nucleotide sequence ID" value="XM_009171901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADL3"/>
    <dbReference type="STRING" id="6198.A0A075ADL3"/>
    <dbReference type="GeneID" id="20320777"/>
    <dbReference type="KEGG" id="ovi:T265_06598"/>
    <dbReference type="CTD" id="20320777"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="5">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22010" checksum="439BF3FCCC8A58FD" modified="2014-10-01" version="1">MLSVAREREVEGDLILGDIGCGVPFRGGSFDGAVSVSAIQWLCNADRTEHNPVARIRCFFTSLYACLSRTARAVLQFYPESISQADLLQNEAMRAGFSGGLIIDFPNSTRAKKYFLVLDVTNYRRLPQALTEGGYQDVPTGVSGGKRSEARECHRFKKPPKHSVAWIKQKKERARKQMKEVAHDSKYTGRKRAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADL8</accession>
    <name>A0A075ADL8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162075.1">
        <property type="nucleotide sequence ID" value="XM_009163811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADL8"/>
    <dbReference type="GeneID" id="20314342"/>
    <dbReference type="KEGG" id="ovi:T265_00154"/>
    <dbReference type="CTD" id="20314342"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10604" checksum="9004468FED2EC011" modified="2014-10-01" version="1">MKTDEKLAGETTIFGIRLYSTKVTGFYEEVSRSKRSTIEVSPKRLIRKFGSVWNQAWTAGFRDVSGSSITTSDLVALYPLMIARMVVEPHTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE95</accession>
    <name>A0A075AE95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169694.1">
        <property type="nucleotide sequence ID" value="XM_009171430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE95"/>
    <dbReference type="GeneID" id="20320404"/>
    <dbReference type="KEGG" id="ovi:T265_06222"/>
    <dbReference type="CTD" id="20320404"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10947" checksum="623CDA5F35FCDA3A" modified="2014-10-01" version="1">MDDADDNPELVILTSIFDDDSDSRLFGTMNDAGLPGSETMWQIDDARLPFPGIATTEIRQQMPTPRPTWVVVQSTSFVHRIITRLNITLANTVLGLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHH6</accession>
    <name>A0A075AHH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166371.1">
        <property type="nucleotide sequence ID" value="XM_009168107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHH6"/>
    <dbReference type="GeneID" id="20317775"/>
    <dbReference type="KEGG" id="ovi:T265_03588"/>
    <dbReference type="CTD" id="20317775"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27120" checksum="518EEEFCCD334326" modified="2014-10-01" version="1">MSNQLRREQGRFQYSNRLFLMTIESESVGHLPLGDQTSPELHTRIGEHKRSINRPPRISGANQRFGNGRGSRFILLKNVSRLSLGSKHSNCNKEPVSENIDVGRGLKIHVEALVAKRLDFIVVRWFAFLNKPMSCTGGLPYSIHRVTYQVGNWDNGGQPQLHSGRAFESKDFGDDEDEEEIESSGEADWVRPSTLSGSSRVRRTSPGSILSAAEVSMRLSILESINSMADDLPCLAAIRSTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHR8</accession>
    <name>A0A075AHR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165915.1">
        <property type="nucleotide sequence ID" value="XM_009167651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHR8"/>
    <dbReference type="GeneID" id="20327353"/>
    <dbReference type="KEGG" id="ovi:T265_13185"/>
    <dbReference type="CTD" id="20327353"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704613" evidence="1">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="23547" checksum="94690C2822CD5EFC" modified="2014-10-01" version="1" fragment="single">MWAKRWTIILLFAFCGYERCATESDRITVALRIVPENGSKVHFEGSFGRTDPTILTTPSYDTSSGQIVCGSATVSLESSTKDPVWHPKKETCSSSDTNTTINVNEKLIKGKQEDCGELFIACCTFEAGCSKNITTRVLKSEFNCSHPAEEMWVVLIRYAPQCTYDYEFKWVYGKSAYREPAGTCVAANILACDLTTWLNADTLIENADEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN3</accession>
    <name>A0A075AIN3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_01869</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164259.1">
        <property type="nucleotide sequence ID" value="XM_009165995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN3"/>
    <dbReference type="STRING" id="6198.A0A075AIN3"/>
    <dbReference type="GeneID" id="20316057"/>
    <dbReference type="KEGG" id="ovi:T265_01869"/>
    <dbReference type="CTD" id="20316057"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="57"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="256"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="456" mass="50897" checksum="3039169ED9BC3FC6" modified="2014-10-01" version="1">MSFANSRECISIHIGQAGVQMGNACWELYCLEHGLPADGQLSYAGLHPMLEEDSLQLSTFFSETVQGKHVPRALFVDLEPSVIDEIRTGIYRQLFHPDNLISGKEDAANNYARGHYTVGKDLVDTVMDHIRKTADHCQGLQGFLIFHSFGGGTGSGFTSLLMEKISVDYGKKSKLEFCVYPAPQISTAVVEPYNALMNTHVTLEHSDCSFIFDNEAIYDICRRNLGIDRPTYTNLNRLVGQIVSSFTASLRFEGSLNVDLVEFQTNLVPYPRIHFPLVTYAPTISADKAYHEQMSVAELTNACFEPANQMVKCDPRHGKYMACCLLYRGDVIPKDVNDAVSSIKSKRTIQFVDWCPTGFKIGINYQPPTVVPGGDLAQVNRAACMLSNTTAVAEAWARLTHKFDMMYAKHAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAETVQVDDKEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIQ6</accession>
    <name>A0A075AIQ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_01827</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164201.1">
        <property type="nucleotide sequence ID" value="XM_009165937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIQ6"/>
    <dbReference type="STRING" id="6198.A0A075AIQ6"/>
    <dbReference type="GeneID" id="20316015"/>
    <dbReference type="KEGG" id="ovi:T265_01827"/>
    <dbReference type="CTD" id="20316015"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="439" mass="49840" checksum="D0543B5A13CD73C5" modified="2014-10-01" version="1">MHDPSSRNGKQLTASFPYIFLTINPIAYCFSLLMGLLTKIKLFIAFLIGIKSGTILDSLEDKKLDLSAFSTKTAYRYCGLTPFNDGTLQKLDSCKPIHINGIYRHGTRAPSLKDVQRVRDLRAKLLSSENVMLPSGFRDYPVPFANETDRGLLPRGLEELHSLGQRIRNRMPPWFESTDGIKFYTSSSSRAILSARSFYHGLFNLTPLDAQNTWDAELHLNALPETIQIADRFTRLFESCKRYATEIGKNKSALEEHFKFIDGAEMKEAFKEIMSRNRLPASKFSTGDIYIMFRICGYEIAVFSNDQSPWCGFLRKNYQPILEYILDLKSSSAVHIRWLCRDLDPGQLTCGAGVLRLLQRTLDASEFSHLNRRTCSRLSEVTGMAEQSNDDPVTGFDDRLTRQSGLPSQVGSYRKCPYAVSRKKQLRIAVYIVLSTKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIS8</accession>
    <name>A0A075AIS8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transferrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164128.1">
        <property type="nucleotide sequence ID" value="XM_009165864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIS8"/>
    <dbReference type="STRING" id="6198.A0A075AIS8"/>
    <dbReference type="GeneID" id="20315962"/>
    <dbReference type="KEGG" id="ovi:T265_01774"/>
    <dbReference type="CTD" id="20315962"/>
    <dbReference type="OrthoDB" id="9981115at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13529">
        <property type="entry name" value="PBP2_transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000095">
        <property type="entry name" value="Lactotransferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00422">
        <property type="entry name" value="TRANSFERRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00094">
        <property type="entry name" value="TR_FER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Transferrin-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin-like" evidence="3">
        <location>
            <begin position="541"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="918" mass="104292" checksum="025D896585CF1A5A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIV1</accession>
    <name>A0A075AIV1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Palmitoyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_01699</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="15"/>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164029.1">
        <property type="nucleotide sequence ID" value="XM_009165765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIV1"/>
    <dbReference type="STRING" id="6198.A0A075AIV1"/>
    <dbReference type="GeneID" id="20315887"/>
    <dbReference type="KEGG" id="ovi:T265_01699"/>
    <dbReference type="CTD" id="20315887"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF466">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="16">
        <location>
            <begin position="405"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="70197" checksum="EF98FBAEDD468947" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJL5</accession>
    <name>A0A075AJL5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162559.1">
        <property type="nucleotide sequence ID" value="XM_009164295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJL5"/>
    <dbReference type="GeneID" id="20314679"/>
    <dbReference type="KEGG" id="ovi:T265_00491"/>
    <dbReference type="CTD" id="20314679"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="32310" checksum="73F07E16385599EA" modified="2014-10-01" version="1">MCTRLHFDWVVAKTWAFDSISAFVTSSGSMAASGTRWLGWLEREATDRKVRGSNLTSASRLSLSRLRQPGSILAIVLPSGGVTAWHRKGVTSGRLSCCLSSPLVRLSMVKDRPYTRVKLQGIENIWIHNQLFCSGTVNCVAPERIHKIHQVVVIIIIDSMTSVFNTDASMPYSRDSFESLIVKKRVKCLQPGTVRIRRSPSWKASSTDSTQAFRDLLHTPLPSRATMDNRSAVTLFRCLAAMPPGGSKRARILPGCPSLVKGSREADVEIEPRTFRLEIRALTTEPSCPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJN2</accession>
    <name>A0A075AJN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162630.1">
        <property type="nucleotide sequence ID" value="XM_009164366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJN2"/>
    <dbReference type="STRING" id="6198.A0A075AJN2"/>
    <dbReference type="GeneID" id="20314750"/>
    <dbReference type="KEGG" id="ovi:T265_00562"/>
    <dbReference type="CTD" id="20314750"/>
    <dbReference type="OrthoDB" id="1728874at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14211" checksum="E56DC6A87FC4C856" modified="2014-10-01" version="1">MNQLTEFPVELCTATIPINMLDLSHNMIAAVPSCVSTLQAIELNLNNNRINLVASTIAQCPRLKVLRLESNQLTLEQFPKELFTESQVSLLCVTENKFDMRDFYSLPDYAKYMDRFTAMKKKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTR1</accession>
    <name>A0A074YTR1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL610519">
        <property type="protein sequence ID" value="KER18113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178140.1">
        <property type="nucleotide sequence ID" value="XM_009179876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTR1"/>
    <dbReference type="GeneID" id="20326539"/>
    <dbReference type="KEGG" id="ovi:T265_12371"/>
    <dbReference type="CTD" id="20326539"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7640" checksum="64CD222BDC4B7A11" modified="2014-10-01" version="1">MFSSSPLSFSGPHDAADCVDFLCESICRSSAPANYDNDPIRRRTGFALANATFVTVHNDRPFARLFNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTU8</accession>
    <name>A0A074YTU8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606305">
        <property type="protein sequence ID" value="KER18206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178047.1">
        <property type="nucleotide sequence ID" value="XM_009179783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTU8"/>
    <dbReference type="STRING" id="6198.A0A074YTU8"/>
    <dbReference type="GeneID" id="20330387"/>
    <dbReference type="KEGG" id="ovi:T265_16222"/>
    <dbReference type="CTD" id="20330387"/>
    <dbReference type="OrthoDB" id="2133912at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12615" checksum="F8C8356048160C25" modified="2014-10-01" version="1" fragment="single">TPKPVPRHRSTARANVLPTTSEGDLSELSQISSIPTEDVQAATALSDVETDEVEIQIHHLDLDQGIIKETWQRVCVNYEFLDDTESTETTLLPKGVISEDGKQQWTATFDYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU53</accession>
    <name>A0A074YU53_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603274">
        <property type="protein sequence ID" value="KER18331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177922.1">
        <property type="nucleotide sequence ID" value="XM_009179658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU53"/>
    <dbReference type="GeneID" id="20326472"/>
    <dbReference type="KEGG" id="ovi:T265_12304"/>
    <dbReference type="CTD" id="20326472"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8482" checksum="E2A2C7B3E341CC2E" modified="2014-10-01" version="1">MYPNIPEINVYEVTIDVMPLLPQWDRNSLILMTTLCSLLQRLRCVNMPPDSQVLPVLNTPFCKFVLLRNEASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUD6</accession>
    <name>A0A074YUD6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601727">
        <property type="protein sequence ID" value="KER18406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177847.1">
        <property type="nucleotide sequence ID" value="XM_009179583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUD6"/>
    <dbReference type="STRING" id="6198.A0A074YUD6"/>
    <dbReference type="GeneID" id="20330243"/>
    <dbReference type="KEGG" id="ovi:T265_16078"/>
    <dbReference type="CTD" id="20330243"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12532" checksum="DE1483257A7CA304" modified="2014-10-01" version="1" fragment="single">MCGLCTIVKFLRRIRAKPTGLFMKLSAHDSSPGALSSANATILAAEQSGVTPDLLRAVVINARQYEAFLEVLEKELIEMTANADRLCNIFKSQMKQLRELVSDRSVIPSMEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVS2</accession>
    <name>A0A074YVS2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_03554</name>
        <name evidence="19" type="ORF">T265_03555</name>
        <name evidence="17" type="ORF">T265_05707</name>
        <name evidence="16" type="ORF">T265_10277</name>
        <name evidence="15" type="ORF">T265_12164</name>
    </gene>
    <organism evidence="15 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL598073">
        <property type="protein sequence ID" value="KER18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596970">
        <property type="protein sequence ID" value="KER21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166330.1">
        <property type="nucleotide sequence ID" value="XM_009168066.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166331.1">
        <property type="nucleotide sequence ID" value="XM_009168067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169044.1">
        <property type="nucleotide sequence ID" value="XM_009170780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174861.1">
        <property type="nucleotide sequence ID" value="XM_009176597.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177485.1">
        <property type="nucleotide sequence ID" value="XM_009179221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVS2"/>
    <dbReference type="STRING" id="6198.A0A074YVS2"/>
    <dbReference type="GeneID" id="20317741"/>
    <dbReference type="GeneID" id="20317742"/>
    <dbReference type="GeneID" id="20319889"/>
    <dbReference type="GeneID" id="20324445"/>
    <dbReference type="GeneID" id="20326332"/>
    <dbReference type="KEGG" id="ovi:T265_03554"/>
    <dbReference type="KEGG" id="ovi:T265_03555"/>
    <dbReference type="KEGG" id="ovi:T265_05707"/>
    <dbReference type="KEGG" id="ovi:T265_10277"/>
    <dbReference type="KEGG" id="ovi:T265_12164"/>
    <dbReference type="CTD" id="20317741"/>
    <dbReference type="CTD" id="20317742"/>
    <dbReference type="CTD" id="20319889"/>
    <dbReference type="CTD" id="20324445"/>
    <dbReference type="CTD" id="20326332"/>
    <dbReference type="OrthoDB" id="6256412at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER27172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER29968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13649" checksum="7C9FCE11A973256A" modified="2014-10-01" version="1">MAPKVVSGKAAKKASKVKVPKVDKKKKRRRKESYAIYIYKVLRQVHPDTGISSKAMSIMNSFVNDIFERIAAESSRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXS0</accession>
    <name>A0A074YXS0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597201">
        <property type="protein sequence ID" value="KER19468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176789.1">
        <property type="nucleotide sequence ID" value="XM_009178525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXS0"/>
    <dbReference type="STRING" id="6198.A0A074YXS0"/>
    <dbReference type="GeneID" id="20325939"/>
    <dbReference type="KEGG" id="ovi:T265_11771"/>
    <dbReference type="CTD" id="20325939"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="34081" checksum="793530195E6D1EA3" modified="2014-10-01" version="1">MRAPFSQSTGFLRMEYMVHLLTGILFVAVFGCLCYLIWFRKLICHGWLSPLAWKFTCMRSQSNMRSPVSTKKGCSVIVENEPRFFNRTYPKHSYVETFHVIANQLDGPGLRECGSNLLYTERQGECLAITPMEFQIIRGRSTLPTKKPNDERRKLQETYQESTEEKLTQQTSNSFSYTDLLKKMSLINREEDSFQSANKPYFSRNQATSRRLQRLSLAHQMLSLNDQSSNTTAALSQQLDYQHSTRFHTQATWNTEKPRGINYAMGCQQATRRTSSPEVQPYNIPLLLPSTAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z058</accession>
    <name>A0A074Z058_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597702">
        <property type="protein sequence ID" value="KER18857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177396.1">
        <property type="nucleotide sequence ID" value="XM_009179132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z058"/>
    <dbReference type="STRING" id="6198.A0A074Z058"/>
    <dbReference type="GeneID" id="20329951"/>
    <dbReference type="KEGG" id="ovi:T265_15786"/>
    <dbReference type="CTD" id="20329951"/>
    <dbReference type="OrthoDB" id="6147836at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19811" checksum="EA2A3A6CAB8D205D" modified="2014-10-01" version="1" fragment="single">MGTIAEPDKSREKQRYSIAKKAGHEAYHRRKHILEQELAEAEAQFSDMDWIRNPEQTQNAENRLHKEFRQKYLALDQEARAINHDLLLTHQQRVSHSVGKRFEAAALAWDNAVRNAPSNEFRQKYLALDQEARAINHDLLLTHQQRVSHSVGKRFEAAALVWDNAVRNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0E4</accession>
    <name>A0A074Z0E4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597061">
        <property type="protein sequence ID" value="KER20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175860.1">
        <property type="nucleotide sequence ID" value="XM_009177596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0E4"/>
    <dbReference type="STRING" id="6198.A0A074Z0E4"/>
    <dbReference type="GeneID" id="20325219"/>
    <dbReference type="KEGG" id="ovi:T265_11051"/>
    <dbReference type="CTD" id="20325219"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="33290" checksum="CC7E3DBAF5DD9F28" modified="2014-10-01" version="1">MCERGWAGKDLGKRGAKRHHKLLRDNIQGITKPTVCHLARRANQRILCIQEDLSDISAALTRQSREVTSFLGTTSPSSRTLSVTKSHVHRVSGRFGVRPQSHWEYSGYFNGFSEAEKQAGLKNLRNHSGYLQFHDMHRKKLSLHFLEHVREEDIRPTDAANEQDNSLAGDAKRIYRKKTYYSHASPISSIAVTLSLDRDLPLKYGALIKDTTVFQDTQPDGLRSLILSHATNSLLYGHQGSRWLEYKPSDGKYRSLRRTPALRPLLLGLDGMSTNLHSSGDPHKASVWPNVMPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z114</accession>
    <name>A0A074Z114_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein SERAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597027">
        <property type="protein sequence ID" value="KER20721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175533.1">
        <property type="nucleotide sequence ID" value="XM_009177269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z114"/>
    <dbReference type="STRING" id="6198.A0A074Z114"/>
    <dbReference type="GeneID" id="20324965"/>
    <dbReference type="KEGG" id="ovi:T265_10797"/>
    <dbReference type="CTD" id="20324965"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER20721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="86432" checksum="3FC79A4C35B3F031" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z128</accession>
    <name>A0A074Z128_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597025">
        <property type="protein sequence ID" value="KER20746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175498.1">
        <property type="nucleotide sequence ID" value="XM_009177234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z128"/>
    <dbReference type="GeneID" id="20324935"/>
    <dbReference type="KEGG" id="ovi:T265_10767"/>
    <dbReference type="CTD" id="20324935"/>
    <dbReference type="OrthoDB" id="10595501at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13408" checksum="04A2E7B34580771D" modified="2014-10-01" version="1">MDTRADDRRADELVKPNSITFCTVRVPARALPSSHSSVPQYDRPDDANSAASPHLVFWFLIFHRYNFLVVSGKKPPVPPHLVFCSPSLTTNDQMLFDILSENAQQLCFPARAGLVVTNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1F9</accession>
    <name>A0A074Z1F9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597019">
        <property type="protein sequence ID" value="KER20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175449.1">
        <property type="nucleotide sequence ID" value="XM_009177185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1F9"/>
    <dbReference type="GeneID" id="20324893"/>
    <dbReference type="KEGG" id="ovi:T265_10725"/>
    <dbReference type="CTD" id="20324893"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10520" checksum="42F18264305ED1A7" modified="2014-10-01" version="1">MSASSWLGVESAETTPNYKPETSNPDRLRPMDSYMGRKTSLYQKSKFVYELWNLDDASTGTVYLPTTEPALYRTDRILNIPPQFNRLVHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2H8</accession>
    <name>A0A074Z2H8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596980">
        <property type="protein sequence ID" value="KER21261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174982.1">
        <property type="nucleotide sequence ID" value="XM_009176718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20324533"/>
    <dbReference type="KEGG" id="ovi:T265_10365"/>
    <dbReference type="CTD" id="20324533"/>
    <dbReference type="OrthoDB" id="10403167at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703861" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13820" checksum="287F411A20250D96" modified="2014-10-01" version="1">MTTHKLMHFSYLLLMLMGLLRSTEFCEPIPAENQFRXLGGLRWEMQHLSAELNTNWQMGVEMGFCAKQCKSQPNCFGFNWWNPGNACQLDNTGGSYILSSSSVELYEMKCCGKSAIHICEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2I2</accession>
    <name>A0A074Z2I2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596980">
        <property type="protein sequence ID" value="KER21266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174987.1">
        <property type="nucleotide sequence ID" value="XM_009176723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2I2"/>
    <dbReference type="GeneID" id="20324536"/>
    <dbReference type="KEGG" id="ovi:T265_10368"/>
    <dbReference type="CTD" id="20324536"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10870" checksum="C2A58A18C44A97A3" modified="2014-10-01" version="1">MSAFAYHRQFGVEAQHKADGNSVRVTDNQAEIAHWLRREHIHWKVSGSNPTSASRLLLSSPGQRDKFPVSTLASNGTAAGHHSRASVALTDQLTRIARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2M4</accession>
    <name>A0A074Z2M4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596976">
        <property type="protein sequence ID" value="KER21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174944.1">
        <property type="nucleotide sequence ID" value="XM_009176680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2M4"/>
    <dbReference type="STRING" id="6198.A0A074Z2M4"/>
    <dbReference type="GeneID" id="20329285"/>
    <dbReference type="KEGG" id="ovi:T265_15120"/>
    <dbReference type="CTD" id="20329285"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="33167" checksum="20387C5741C76FD3" modified="2014-10-01" version="1" fragment="single">MVEGYEIGYKKSVSLSRIEIGRCKIWLQIDVGDALLVGFHPRCLNECFNFNFPLINYKAREYHRHHRQHDISVQHRRFTAVCAIHGCTWAGILPGRPHLDRRTIRVLNQSLWLKSLTARQRCLARNANALPFLRKKLPHVPTPNLEGQVTVFVRPLTIDQPGMTLTLSSIAQWIAEVRKPSHHGKVQSLCDGSSCSFMCYACQNTVYRDECCSPCLLQDGANREFHVLRMPKHRLPRRVLFSVPPSGWRKPRGGQHMTWQKGVKEITKSLGVVGVVRLPGWGPCDPICALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2T1</accession>
    <name>A0A074Z2T1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596978">
        <property type="protein sequence ID" value="KER21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174958.1">
        <property type="nucleotide sequence ID" value="XM_009176694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2T1"/>
    <dbReference type="GeneID" id="20324517"/>
    <dbReference type="KEGG" id="ovi:T265_10349"/>
    <dbReference type="CTD" id="20324517"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="32668" checksum="987D50E2F2579793" modified="2014-10-01" version="1">MHTAAKRRVPRNGTQPPVQIPKDHCQCSALIGILDAKIERLSKALEDSGAKNAATWAKVDKEHSSLNQYLAMSIPGPMAEKKVIQLSDAAIKTATASLVERRLRENRLIIWGSFSGKITPAKLAQSILSKPDQSLHAEWLRQEGSKRTLGLLVTLSSPSDVQAILERAGSIQKAIPKNKTDPGNLGKCLDPLQTIAVFASHAPYNCYTSNLAGNGRHPHSGRNNLRLYVLLTIYVNFLVQPRSSCYGNAYTLTDCNDFDGRCGAVLKPKYISAMKAWRCLTLADGTLASILFLPATHSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2V1</accession>
    <name>A0A074Z2V1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597128">
        <property type="protein sequence ID" value="KER19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176407.1">
        <property type="nucleotide sequence ID" value="XM_009178143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2V1"/>
    <dbReference type="GeneID" id="20325644"/>
    <dbReference type="KEGG" id="ovi:T265_11476"/>
    <dbReference type="CTD" id="20325644"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8150" checksum="B983E4BD892A2301" modified="2014-10-01" version="1">MCVTKHAEAMPSTAEDVRSFARSAVTPFRCLAATLPEGSTKAETLSGCPGLDRGSREAEVGFESRTFWSVNSDSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z463</accession>
    <name>A0A074Z463_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596937">
        <property type="protein sequence ID" value="KER21843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174424.1">
        <property type="nucleotide sequence ID" value="XM_009176160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z463"/>
    <dbReference type="GeneID" id="20329169"/>
    <dbReference type="KEGG" id="ovi:T265_15003"/>
    <dbReference type="CTD" id="20329169"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="11295" checksum="BBC8B8AD481ABAD7" modified="2014-10-01" version="1" fragment="single">MDTRLLARRRPPTAYLLRNQVDHITNKSPNTPLRYEFVYFGSWTWPISISPVRPRFENYPKDVKEAYPKRRTALVAVVETLYDRRRCIQRKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4J4</accession>
    <name>A0A074Z4J4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KL597057">
        <property type="protein sequence ID" value="KER20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175810.1">
        <property type="nucleotide sequence ID" value="XM_009177546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4J4"/>
    <dbReference type="GeneID" id="20325177"/>
    <dbReference type="KEGG" id="ovi:T265_11009"/>
    <dbReference type="CTD" id="20325177"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="444" mass="50864" checksum="977308A3F66E790C" modified="2014-10-01" version="1">MGIISTTWLCWIMFNRNREYQASPLPRLPDLTFATIDEENETFAVSAYLEEYSRKVRVFALKKDTAAPLVYCFYWGNTFENYGKPVWNSAEVFAFERLKYAFRQLGAIQPTESYGAYVTFCRVPSGMMGQIVDGKVGIALHVGTASYKPPVVLQIHPGQVVEKKDATLDPTYRKWKPPRKVGLCVAPIYDLGVTVTTSYLVSYIELYRVTGVSLMVFYIVPEVIKYVQPILDSYANKLLFENGDKFELLVLTWQPPLNEIDSQLEESDEILGYNDCIYRISREVEYILHANLKEIVLPKQNPNSIRLTEWSNVIRVLRDVNYAKRPTTCFPARYFPPIRRHLKTTESIFERVWATRNLSGNLSRCITHSGEVFDVDIHAPITPPRLNNGTDLATVLIFDNCDADEITTCTAENALVINEELTPYLSKIQPSIERRMAQLESQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z595</accession>
    <name>A0A074Z595_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596907">
        <property type="protein sequence ID" value="KER22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173955.1">
        <property type="nucleotide sequence ID" value="XM_009175691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z595"/>
    <dbReference type="GeneID" id="20323750"/>
    <dbReference type="KEGG" id="ovi:T265_09582"/>
    <dbReference type="CTD" id="20323750"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7389" checksum="CA978F9DAAFA126E" modified="2014-10-01" version="1">MTWIVAIRPMPPLQMKVGDRNSVHSAQSWMILECIESNQRADKETLKTALDGESWEIHQHDVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5R7</accession>
    <name>A0A074Z5R7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597013">
        <property type="protein sequence ID" value="KER20877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175379.1">
        <property type="nucleotide sequence ID" value="XM_009177115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5R7"/>
    <dbReference type="GeneID" id="20324832"/>
    <dbReference type="KEGG" id="ovi:T265_10664"/>
    <dbReference type="CTD" id="20324832"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="27732" checksum="C3359D0D63C57C6C" modified="2014-10-01" version="1">MTSEEVGASWFKWLERKFTDRKVRGSNPTSVSRLPLSRLGQPDGISALMLPLGGMAAGHRKGVTAERFFYIWQEIKRNKKMAEISQYSQLSFDGSNGIIPRASMNPRIHVPICNLSGASNKIAKALCFGTAKRRAALCCRATRWKHEGGYTVRLPKPIQEIYSRDTVAGLEPKLLTEMSLAQWLEREVGHRKVRASNQTSASRLSQSRLGKPGSNPAFVLPSGGMVTRYRKGATGERFEVFLVSHLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6S2</accession>
    <name>A0A074Z6S2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173497.1">
        <property type="nucleotide sequence ID" value="XM_009175233.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z6S2"/>
    <dbReference type="GeneID" id="20328950"/>
    <dbReference type="KEGG" id="ovi:T265_14784"/>
    <dbReference type="CTD" id="20328950"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="4">
        <location>
            <begin position="445"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1366" mass="152374" checksum="9FD9AABA31BE7A12" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7A6</accession>
    <name>A0A074Z7A6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174796.1">
        <property type="nucleotide sequence ID" value="XM_009176532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7A6"/>
    <dbReference type="GeneID" id="20324391"/>
    <dbReference type="KEGG" id="ovi:T265_10223"/>
    <dbReference type="CTD" id="20324391"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="384" mass="43031" checksum="7256B62FCA9FC98E" modified="2014-10-01" version="1">MVYTAVTPFRCLAVCHRRKYEGWNITRLPKPRQEKSRCRGRFQTMDLPFNKSALQPQPSHQCQNTAGCPGARWPNWLEREFTDQKVHGLNPTSASRLPLSRLWQPGSIPALVQPSGGMAVRHRKGATAGRFFGCLGTAIQPILTAHSRPMQGMCSVGWPPSWGASWLSSYSANLLTGESGRTRLPPLDFRCLGLGNLVVSQPSCFIRVAWQLITERITQTFSTRRGASWLSSYSANLLTGESGRTRPPPLDFRCLGLGNLVVSQPSCFIRVAWQLITERITQTFSTRRGASWLSSYSANLLTGESGRTRPPPLDFRCLGLGNLVVSQPSCFIRVAWQLITERLLVSITGKRETEHTTKPWRSIVSLQLVRWDTGKGRRPRQEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Z2</accession>
    <name>A0A074Z7Z2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596854">
        <property type="protein sequence ID" value="KER23326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172927.1">
        <property type="nucleotide sequence ID" value="XM_009174663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Z2"/>
    <dbReference type="GeneID" id="20322950"/>
    <dbReference type="KEGG" id="ovi:T265_08771"/>
    <dbReference type="CTD" id="20322950"/>
    <dbReference type="OrthoDB" id="6227722at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="264" mass="30429" checksum="6075490C4FF48D60" modified="2014-10-01" version="1">MTSKDVELNPLVNQPVDKKSKQVVNKEIPVAQLGRTKLKDSEAFNDRTANNLLDKHLKKKGKPSPVFFLVDRMRFKKKGHHEYLNYREVHSFHKFANHPNVFMLFVIEEKKGKRSYETYSCNNSADVQCIRDMIGTIQDDPKRLLQGLGPVRVVSLSSSSSSEYHIERRLSNRSSQSRSVAYRPYSQQEPAEYLYIVDPEQSTGQQTLQPVQKRVSNGIINSRMNSFNGSQAPDHGPVYVYGSRSSRNLYRDGYSPEYSRRKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z807</accession>
    <name>A0A074Z807_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596853">
        <property type="protein sequence ID" value="KER23341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172906.1">
        <property type="nucleotide sequence ID" value="XM_009174642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z807"/>
    <dbReference type="STRING" id="6198.A0A074Z807"/>
    <dbReference type="GeneID" id="20322932"/>
    <dbReference type="KEGG" id="ovi:T265_08753"/>
    <dbReference type="CTD" id="20322932"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47291" checksum="BC5EC6B665804C3B" modified="2014-10-01" version="1">MRVFFESIRDIYGELLHTAFFVALFWTAVTILAFVGRRLVLFLSAPTRTSDNDRTRDTTCQTSSDSRVSGSTALESPSFLSSISGRFRFSPPMVLALFDALATMELCACSLECWPIRAVAGHHGLLAAIGMNTIRGATFTCMDAYGNPTNPWYRFLVGQSDFTWVAITWILQLLGAHAALQLAEIWWSLRPTVQHAARHQLALTLRQTPSPELPPVSAPIQSDLQVSPLFGFIVEAFGSCVEFYLAFICSCVIGWWNRRRAFPEPPSVATSCADSLTGEVENIPQSRIQFIGSFILRLCINLTITSKCLGLTGNYINPANAFIQSYGVGGVSTQTHLLVYWLGPFFGVWLAVQLQHWTVKFLEPSSLQVDSDCLFSETSSPSKQPPLNGKPCSPSTPSPDSVQYDSFCSSASIDVGPSGTSVSQRRWSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8G0</accession>
    <name>A0A074Z8G0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596936">
        <property type="protein sequence ID" value="KER21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174402.1">
        <property type="nucleotide sequence ID" value="XM_009176138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8G0"/>
    <dbReference type="STRING" id="6198.A0A074Z8G0"/>
    <dbReference type="GeneID" id="20324090"/>
    <dbReference type="KEGG" id="ovi:T265_09922"/>
    <dbReference type="CTD" id="20324090"/>
    <dbReference type="OrthoDB" id="6244401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="253"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="877"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="877"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113336" checksum="92AFD7C71D1D6E9B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Q7</accession>
    <name>A0A074Z8Q7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596928">
        <property type="protein sequence ID" value="KER21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174286.1">
        <property type="nucleotide sequence ID" value="XM_009176022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8Q7"/>
    <dbReference type="GeneID" id="20324004"/>
    <dbReference type="KEGG" id="ovi:T265_09836"/>
    <dbReference type="CTD" id="20324004"/>
    <dbReference type="OrthoDB" id="6257969at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7593" checksum="847F179DC7E20D15" modified="2014-10-01" version="1">MHLIGGRTLGHKGKKTDDRSNDNMASEDAEKRLTEYLAKLDVEISALKLLLLKRFNEVRKRNIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8X2</accession>
    <name>A0A074Z8X2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172696.1">
        <property type="nucleotide sequence ID" value="XM_009174432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8X2"/>
    <dbReference type="GeneID" id="20328784"/>
    <dbReference type="KEGG" id="ovi:T265_14618"/>
    <dbReference type="CTD" id="20328784"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="30431" checksum="DB77D58798564621" modified="2014-10-01" version="1">MHYRSAVGTDLTTDCSCLGLGNLTAAQSVCFLQAVCQLDTQGILQQPSLRQTSLWLLMSLLCGRPTITVGRFERVSNNISFTRLKHEAAWCSTFSCLGTSQTRDSVGFQVDRMISACCAFMKYIKSIKETTHKVAKTSSTAHDRFRPTNSGSSDSRSPLVSVNLMFYLNPNWTNYTHLQSNLFFTRGPTESRVYAILQLNVLHTGRLMFQWARYSEYRSIFHKGNCSQGWWKLFDSPRPVSPFPFELIRVQPRWSLAAFWADGPSTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z922</accession>
    <name>A0A074Z922_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596842">
        <property type="protein sequence ID" value="KER23623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172617.1">
        <property type="nucleotide sequence ID" value="XM_009174353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z922"/>
    <dbReference type="GeneID" id="20322703"/>
    <dbReference type="KEGG" id="ovi:T265_08524"/>
    <dbReference type="CTD" id="20322703"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="20052" checksum="B18C2E397A6CF01A" modified="2014-10-01" version="1">MTSVVNTNASLPYNHHLFERVMVKKRIETFIQAIWIETDNKNATDIGWQPYLVMSPSRHSEDHAVLILEGDTFVQDVASIDVYASWYSAKRKATKSQHIQNHKTTHKVDEYSSTAHDRFHPSWDSLGRRSFRDVVNLMFYLKPNWTDFDKCTQSHYKLFFTSDSNESLVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAX0</accession>
    <name>A0A074ZAX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172013.1">
        <property type="nucleotide sequence ID" value="XM_009173749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAX0"/>
    <dbReference type="STRING" id="6198.A0A074ZAX0"/>
    <dbReference type="GeneID" id="20322234"/>
    <dbReference type="KEGG" id="ovi:T265_08055"/>
    <dbReference type="CTD" id="20322234"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22791" checksum="D8CD437CF9547A8A" modified="2014-10-01" version="1">MSQWRVQQWRAFTRQWLIYDAYMQCPMMSGEKIAKYLLGKHIRYYDPNSDFGAHVVVCNTRHVAVKDNSYYWKRFLYPTYTRFGAFRKDETMEELHIRDPTEVLRREVRVHLNTPASKLYALARLHLYPDGVETIPEDIFGNISGVIRRVMPVPKRLDQYSQEELQEFPKLFDWPQDFNVAPLGPLDSGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBW5</accession>
    <name>A0A074ZBW5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173154.1">
        <property type="nucleotide sequence ID" value="XM_009174890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBW5"/>
    <dbReference type="GeneID" id="20323126"/>
    <dbReference type="KEGG" id="ovi:T265_08947"/>
    <dbReference type="CTD" id="20323126"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7525" checksum="EF6C89C95AD188AA" modified="2014-10-01" version="1">MYLCGKGICFHLPVEASKFCLKGAQCSQLTAEDFRIDYSENALLTVAAADLTSLHENLGLWYPRATMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBZ8</accession>
    <name>A0A074ZBZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173133.1">
        <property type="nucleotide sequence ID" value="XM_009174869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZBZ8"/>
    <dbReference type="GeneID" id="20323109"/>
    <dbReference type="KEGG" id="ovi:T265_08930"/>
    <dbReference type="CTD" id="20323109"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="21647" checksum="EBF431022E3FDA54" modified="2014-10-01" version="1">MRVSGESLKDRMWIREAVLRRQIEDVIDTVNRLWPELFDKNPFIYFQLRQLQMLELIRNRRLEEALIFAQSYLADPVAKRLSEHPQLLSEMQNTMALLAFDDPSQSIYGRLLGPQHAELVAGALNRAILRHIEASGDDLEGADEGRASTAANLSSYSGSSSTLPRLTKMMAMLLHFKDLAQLELPPELASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCP7</accession>
    <name>A0A074ZCP7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Otopetrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597006">
        <property type="protein sequence ID" value="KER20970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175286.1">
        <property type="nucleotide sequence ID" value="XM_009177022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCP7"/>
    <dbReference type="GeneID" id="20324770"/>
    <dbReference type="KEGG" id="ovi:T265_10602"/>
    <dbReference type="CTD" id="20324770"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="568"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="83240" checksum="A4576CB7889C888B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD98</accession>
    <name>A0A074ZD98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM C-terminal PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596782">
        <property type="protein sequence ID" value="KER25266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170991.1">
        <property type="nucleotide sequence ID" value="XM_009172727.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZD98"/>
    <dbReference type="GeneID" id="20321432"/>
    <dbReference type="KEGG" id="ovi:T265_07253"/>
    <dbReference type="CTD" id="20321432"/>
    <dbReference type="OrthoDB" id="6266247at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM C-terminal PH-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1561"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1726"/>
            <end position="1749"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
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                <person name="Tan P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
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                <person name="Maleewong W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="183" mass="20397" checksum="0E6DFFD571E6CCB1" modified="2014-10-01" version="1" fragment="single">MVLLTILANCIVLAMEVHLPSHDKTALSERLEQTETYFLIIFCVEALLKIVALGFLFHKGAYLRNIWNIIDFIVVVTGLLAYILPNLNQPAVRALRVLRPLKLVTGFESKMVGFIHCCSTLFQGCLFSSGVLFSGLQIVLKSILRAMAPLLQISLLVLFAITIFAIIGLEFYSGAFHMTCFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF98</accession>
    <name>A0A074ZF98_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170310.1">
        <property type="nucleotide sequence ID" value="XM_009172046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF98"/>
    <dbReference type="GeneID" id="20320891"/>
    <dbReference type="KEGG" id="ovi:T265_06712"/>
    <dbReference type="CTD" id="20320891"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12189" checksum="19F713E1413B6000" modified="2014-10-01" version="1">MGVVAKTMQYLYTVEASTERANMGEFHLMDMDGDVIDRSGRQKWNPELFTERRSTNSRFEQVNARYGQASCRPMWYRIIIPVVELRDESICAVCWSLSGVRFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFG6</accession>
    <name>A0A074ZFG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174258.1">
        <property type="nucleotide sequence ID" value="XM_009175994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFG6"/>
    <dbReference type="STRING" id="6198.A0A074ZFG6"/>
    <dbReference type="GeneID" id="20323979"/>
    <dbReference type="KEGG" id="ovi:T265_09811"/>
    <dbReference type="CTD" id="20323979"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000003">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="505" mass="57316" checksum="2EDA23D230460DF1" modified="2014-10-01" version="1">MDTPINKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEVYRPSKAYSEDMTKFHSDEYVKFLKSIRPDNMHEFNKQMQRFNVGEDCPVFDGLFEFCQLSAGGSIAGAVKLNKQQTDIAINWGGGLHHAKKSEASGFCYINDIVMGILELLKYHQRVLYVDIDIHHGDGVEEAFYTTDRVMTCSFHKYGEYFPGTGDSKDIGAGRGKYYALNFPMRDGMDDECYERCFKPVISKVMEYFRPGAVVLQCGADSLSGDRLGCFNLTLKGHGKCVEFIRSFPIPLLLVGGGGYTIRNVARCWTYETSIALATEIPNDLPYNDYYEYFGPDFKLHISPSNMTNQNTPEYLDNIKAKLFENLRMIPHSPSVQMQDIPNDAIDIEEQEAVTRDHADPDRRISIMAADKAVQPNNEFYDEPEEGSGAPKIGKARDVQSHRDTPKRARNDEDLSLPTKDSQTSKRTDAAGDKQFESKPKTSERTETTAGQKRNGVVESENNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGI1</accession>
    <name>A0A074ZGI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596903">
        <property type="protein sequence ID" value="KER22360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173892.1">
        <property type="nucleotide sequence ID" value="XM_009175628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGI1"/>
    <dbReference type="STRING" id="6198.A0A074ZGI1"/>
    <dbReference type="GeneID" id="20329041"/>
    <dbReference type="KEGG" id="ovi:T265_14875"/>
    <dbReference type="CTD" id="20329041"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705219" description="Ion transport domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="188" mass="21724" checksum="1C002AD6AF811ED7" modified="2014-10-01" version="1" fragment="single">MLVLLVANLIMLPVIISFFNDDMSSKWIVFNGISDAIFFMDIIVNFRTGIIRNDFVDDIILDPEEIAREYVRTWFVVDLLSSLPIDYVLLAFRSSEVEGSEQLVQAGRALRILRLAKLLSLLRLLRLSRLVRYITQWEEVVNIANKFMGICNLVLIMLLLGHWNACLQFLVPMLMDFPVQSWVSKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIM2</accession>
    <name>A0A074ZIM2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169395.1">
        <property type="nucleotide sequence ID" value="XM_009171131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIM2"/>
    <dbReference type="GeneID" id="20320161"/>
    <dbReference type="KEGG" id="ovi:T265_05979"/>
    <dbReference type="CTD" id="20320161"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8471" checksum="60772DE3D8079101" modified="2014-10-01" version="1">MKRRVRNSSIPGLTIEHNPQMAGPMASLGNLAVSQPSCLLRVTWQLGTETVLQLNDPMPAVKVDACRIDHASHQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIQ3</accession>
    <name>A0A074ZIQ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169350.1">
        <property type="nucleotide sequence ID" value="XM_009171086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIQ3"/>
    <dbReference type="GeneID" id="20320121"/>
    <dbReference type="KEGG" id="ovi:T265_05939"/>
    <dbReference type="CTD" id="20320121"/>
    <dbReference type="OrthoDB" id="6255265at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121485" checksum="07F71C725003438C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJU0</accession>
    <name>A0A074ZJU0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168930.1">
        <property type="nucleotide sequence ID" value="XM_009170666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJU0"/>
    <dbReference type="GeneID" id="20319789"/>
    <dbReference type="KEGG" id="ovi:T265_05607"/>
    <dbReference type="CTD" id="20319789"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="640" mass="71903" checksum="D84056FDC2FB01A1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK19</accession>
    <name>A0A074ZK19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172570.1">
        <property type="nucleotide sequence ID" value="XM_009174306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK19"/>
    <dbReference type="GeneID" id="20322671"/>
    <dbReference type="KEGG" id="ovi:T265_08492"/>
    <dbReference type="CTD" id="20322671"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="507" mass="59404" checksum="10873B6749CA28F3" modified="2014-10-01" version="1">MCRIRPPHVSVSTIFEILRYMYRRNTIFIRFLKILRQSPTGFPLHGAHRVGAFPWKHHKREIQLDSRKHVVMIWKLVVDQVWLLICSPSLAVDLQTLRHHTSRHPVAPPQSLVATSPRGITRAGMLTGWSSPDKGSRETEVRLEPLTFYSPFYAEKPRSTVQPFHPYWESPTVRISRNSDESRTRDLLARISWLFPQVASKLRNQPRLQIRYPSWRARKKYPLNCALMMSPRMVAKRLQANCQARRTDRQPPDQQPIGIQVYMHMSWRASIPLPLNYRGSTPTNEPPQSLRQVTFNTQSNAYLVNSCLGPLEFWHKCFLPYLNGITGSLSCPFRWCSREKSFSCSTLLVPSFHATRRGHEDWDTHRLPKPIQRKSRGRGRVRTMNLPHSSLSTQADVNKRRPIWHERANGSLNTDSYYVLYIPERKYHDEFCNYPRSVVPITNFITRNPNLICGQLNDETERLQESRLQKVHSRRMNFNRTSLPSREIHSFENQSGFHEILNWSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK53</accession>
    <name>A0A074ZK53_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168585.1">
        <property type="nucleotide sequence ID" value="XM_009170321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK53"/>
    <dbReference type="STRING" id="6198.A0A074ZK53"/>
    <dbReference type="GeneID" id="20327917"/>
    <dbReference type="KEGG" id="ovi:T265_13750"/>
    <dbReference type="CTD" id="20327917"/>
    <dbReference type="OrthoDB" id="5977625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039145">
        <property type="entry name" value="Ribosomal_mL40_metazoa/plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13359:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28999" checksum="DC8F77C97BB9CDB5" modified="2014-10-01" version="1">MAILSLVLAQQPTLLRTVQLFPSMIHTSAVAYAEPLKKKKRIDPLIEQNRLRRRTRKIEKEIKRFNRQQRQLKPVAELEGDRKLLKELESRRRQPVDLSENEIDRRAVLLKQWGRYQTNVARTESQQFSRAMRAQQRALDWLYLTSPELYKAAIQPFYLPTTCTTEGDCVQDILGKIKGPYYTAPRIHGGLVDCPEDYEPPDGEAVDTTPEFTYEFELDRRLLADPTKKKTVVKKQIDPKEETAASSDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKG1</accession>
    <name>A0A074ZKG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_05422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168693.1">
        <property type="nucleotide sequence ID" value="XM_009170429.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZKG1"/>
    <dbReference type="GeneID" id="20319604"/>
    <dbReference type="KEGG" id="ovi:T265_05422"/>
    <dbReference type="CTD" id="20319604"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000050">
        <property type="entry name" value="Cytoskeleton-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000063">
        <property type="entry name" value="Putative cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="300"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="728"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="1177"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1586"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1965"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2153"/>
            <end position="2174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1592"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1608"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1966"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1977"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2161"/>
            <end position="2174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER27531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2193" mass="240465" checksum="A88B381E7CE6A391" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKU4</accession>
    <name>A0A074ZKU4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172299.1">
        <property type="nucleotide sequence ID" value="XM_009174035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKU4"/>
    <dbReference type="GeneID" id="20328688"/>
    <dbReference type="KEGG" id="ovi:T265_14522"/>
    <dbReference type="CTD" id="20328688"/>
    <dbReference type="OrthoDB" id="10618710at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11678" checksum="EDAEFB4ACE7996DC" modified="2014-10-01" version="1" fragment="single">MWWAEQAIMFRVKTLHEEVDLVVHPNVGATEVAVSWKYSSECIARTQDLTVYDRELTPIIQAIETTEHATTVPNLPTCVPLVVGVRGQNENGDGVEATREFTIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLS1</accession>
    <name>A0A074ZLS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168259.1">
        <property type="nucleotide sequence ID" value="XM_009169995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLS1"/>
    <dbReference type="STRING" id="6198.A0A074ZLS1"/>
    <dbReference type="GeneID" id="20327847"/>
    <dbReference type="KEGG" id="ovi:T265_13680"/>
    <dbReference type="CTD" id="20327847"/>
    <dbReference type="OrthoDB" id="5790032at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="36208" checksum="AB52187CD7528551" modified="2014-10-01" version="1" fragment="single">FRSNPTCSHLFLCYIYYGIVEVGSPTQYFKLTFDTGSPILWVPSMRLAQERPMVRSAYVPEAVVRKSGSITLRYGNYIARGDIFSDLVKFNKRPFRTEFAAINTIEGYVDQLYTIDGIFGLGKKQLFREFKTTPLDDMVAQKVIPKRQFAFIFDRGGSSGTVIFGDISKTRFSGTVNYVPVVNKDEWVIKIKSITYEDGTVLASDLSALLDTGAYRTYLPTSFADNLFSGIWKQANLDDLIVRCDAMRLMPTLLLNLEGHQLKWEANKYTEQLDIGQCKSTIQPANLPFSYNAIMGISFLRHFAVIYDVDNDVVGFAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMD0</accession>
    <name>A0A074ZMD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167735.1">
        <property type="nucleotide sequence ID" value="XM_009169471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMD0"/>
    <dbReference type="STRING" id="6198.A0A074ZMD0"/>
    <dbReference type="GeneID" id="20318862"/>
    <dbReference type="KEGG" id="ovi:T265_04680"/>
    <dbReference type="CTD" id="20318862"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8111" checksum="A46DBA22D1A46E39" modified="2014-10-01" version="1">MAGKVVKQLAGSGTGQSLSDIMTAMKHTLSGSLIAKIICKATTEEMISPKRKHLACKTLFQLYHQFPSRSGAVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMF5</accession>
    <name>A0A074ZMF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Armadillo/beta-catenin-like repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167977.1">
        <property type="nucleotide sequence ID" value="XM_009169713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMF5"/>
    <dbReference type="STRING" id="6198.A0A074ZMF5"/>
    <dbReference type="GeneID" id="20319041"/>
    <dbReference type="KEGG" id="ovi:T265_04859"/>
    <dbReference type="CTD" id="20319041"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="739"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123963" checksum="F93B6F8A677BB8F8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP43</accession>
    <name>A0A074ZP43_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167369.1">
        <property type="nucleotide sequence ID" value="XM_009169105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP43"/>
    <dbReference type="GeneID" id="20327657"/>
    <dbReference type="KEGG" id="ovi:T265_13490"/>
    <dbReference type="CTD" id="20327657"/>
    <dbReference type="OrthoDB" id="6237770at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="476" mass="53913" checksum="557C58086369F0C9" modified="2014-10-01" version="1" fragment="single">GIVKPHLEPLLREYPAGSSVQCVSSQQSVLHSLVEMTLVSDNLGRVTADRSSVVWFPIRDSYRIIEAYLACHLRATYMDKLYGQVWLMVPVRVLATERLFVSPNPVVDEEEIVSCKTFSPISEKFPPVLILPFRMDKHMLTREDASVYEVNNQMHSGGHVYHCTLFLPGRSPQVLEDRISVLHLPQTTVLEEVKDNDELLGWFCLTDGYPNEASTYQLTILEQPSNSFYQIDVNELVLTPYSVFGQLRVQCIAEGVWNGQNIVVNGTHNLTYVGSNRMTAKHKALFRINPNQVYYTLVLVSVSIYFGIYGYLLRRTLKDKKADQVPVDPVMIHNVILNIHEVSLGWTDFGHLCSLLHEFNTIHKICFMLAESDLQSQPTSSPNDLQPVEVEPDHSLTSGDSISTDGDIKNSYQDEPLTLNEALMKHQDSRSQRSILLTGEHSLPRFSVLINEPLSYQVSEPISHSLSSQTEQRQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPK2</accession>
    <name>A0A074ZPK2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168525.1">
        <property type="nucleotide sequence ID" value="XM_009170261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPK2"/>
    <dbReference type="GeneID" id="20319468"/>
    <dbReference type="KEGG" id="ovi:T265_05286"/>
    <dbReference type="CTD" id="20319468"/>
    <dbReference type="OrthoDB" id="6266577at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="33809" checksum="7E48B6B37BF26C91" modified="2014-10-01" version="1">MTHSRSRNRKHSRRTSSSSSSSCDSHESDCSKSHRRGYGKNRRNEVKGSGSSTRHARRTQRGDIIHKLAKRVYRMVDEDNRKHIDSKRPSLENTVPSCGCPLNCGAELQKLRDYVNRLHPLLSENNQDNLQQLECFCDVPERLLLEAWTIIGAQKLKELLTEDLLVICARREKRDSKHHQTNSGRPLPPFTSFDELHSNPQPTCGITELWRRSLTELRQLSTEQVKWVLSGSPNANFIALHWDESSKHAAGTTQDDSAPKKDTHLDSNSQLNPMNKEAGELEMRTRAIRSLANAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ85</accession>
    <name>A0A074ZQ85_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170758.1">
        <property type="nucleotide sequence ID" value="XM_009172494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ85"/>
    <dbReference type="GeneID" id="20321244"/>
    <dbReference type="KEGG" id="ovi:T265_07065"/>
    <dbReference type="CTD" id="20321244"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9512" checksum="43E7640F5688E25D" modified="2014-10-01" version="1">MRRDSKMASSWANHSLGSRAPNSDPPEGTRYGLSDCTQKPWRLFLLSPLKCKLDVKVVEEIKAVANGIRPKKLTEKEDNNNCPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR42</accession>
    <name>A0A074ZR42_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167998.1">
        <property type="nucleotide sequence ID" value="XM_009169734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR42"/>
    <dbReference type="STRING" id="6198.A0A074ZR42"/>
    <dbReference type="GeneID" id="20319062"/>
    <dbReference type="KEGG" id="ovi:T265_04880"/>
    <dbReference type="CTD" id="20319062"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="24354" checksum="464FD7843C7962AE" modified="2014-10-01" version="1">MDPIMEDSLPASNVCGAEVLPGRRRDISLSVKGRVFNAAVRSILLYGSETWPLRAEDVKRLSLFDHRCLRSITRIWWEHRISNSEVRRMVFGRNNSPSIDELITLHRVEESQRRSNNGLAAKYESHYQQTQLRWSLPSSWMRTPRRATSMSRDMVRHGPVAPSMALVHPSYYLQCIAPFPIPPLDSPLTVLDLSTNLSSPACNAQLPTPSPNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT35</accession>
    <name>A0A074ZT35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">snRNA-activating protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167252.1">
        <property type="nucleotide sequence ID" value="XM_009168988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT35"/>
    <dbReference type="STRING" id="6198.A0A074ZT35"/>
    <dbReference type="GeneID" id="20318471"/>
    <dbReference type="KEGG" id="ovi:T265_04289"/>
    <dbReference type="CTD" id="20318471"/>
    <dbReference type="OrthoDB" id="6226843at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47185" checksum="66CD1D7EF21A10C2" modified="2014-10-01" version="1">MKEIKPFVFRTSFNPIHGIDEDLSAFIQKFEHVGGIRFTQFSELWCQEKFIHLIYGRQNQAGLSDLLGCLFYRLVDLVQPHKDRTHLGRICALYLLYAFHGKQPVRNQVRIRVCPETWSGIVQLANEARDDGHLDVYYIFRQLCAANAFSFCLLRQALYPGVPLFDSPQMNAETFEAVSKKTTKNPISPYLSLIEAPKTSQVQLHEALCSLDASIKEYTAAKSLLDEAQEESAHVEDLRPATSSGDEEEMNEEFLPGLNFITHPNSLQKLSGIIRELDEEHDSFEKQLVIEDTPKKNVSTDTVENSPLRSPHHLKQTSPSYGQESGSALNTRTKRPLPASTPVGNHPESGTSNVVPCTEHDRDMDDIGTRRRLLKQPSTWKGELKQQTESVRAHGCRRNRARPMEPKLLRPHNSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT84</accession>
    <name>A0A074ZT84_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165618.1">
        <property type="nucleotide sequence ID" value="XM_009167354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT84"/>
    <dbReference type="GeneID" id="20317163"/>
    <dbReference type="KEGG" id="ovi:T265_02975"/>
    <dbReference type="CTD" id="20317163"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11010" checksum="64A104F021CB9D86" modified="2014-10-01" version="1">MHCGYGSRCVGPIFSFSRHFSGQTAPKHPRIQEVGILPQISDQKQIQSSKMGVERATNSNGRNFRPRENSLPQSLKTRAHGALRKRKKLASEKDPQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVJ8</accession>
    <name>A0A074ZVJ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597306">
        <property type="protein sequence ID" value="KER19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177094.1">
        <property type="nucleotide sequence ID" value="XM_009178830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVJ8"/>
    <dbReference type="GeneID" id="20326139"/>
    <dbReference type="KEGG" id="ovi:T265_11971"/>
    <dbReference type="CTD" id="20326139"/>
    <dbReference type="OrthoDB" id="6250480at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012271928" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23957" checksum="4BF491B36626C6AE" modified="2014-10-01" version="1">MYNFCFLILVYASWAVRSDVDCGSGPLQKVSDSCMFKLNGLMGFCAANKQCADRGGSFGQHWFLVGKNAHKIPSSFSEGQSIWTSRTRLFERNPSGHVWRVGDPHWSHYSETTANASAPSNPSVEGSAARITYVQHNGTTNMFYFTRNNKELRGAVCERALVPTPYHPSSNMPLTTEVFRVTWPRPSQSMVLDDRESVGCYANHMAQSIIDCALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVX1</accession>
    <name>A0A074ZVX1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Miro-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166159.1">
        <property type="nucleotide sequence ID" value="XM_009167895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVX1"/>
    <dbReference type="STRING" id="6198.A0A074ZVX1"/>
    <dbReference type="GeneID" id="20317598"/>
    <dbReference type="KEGG" id="ovi:T265_03411"/>
    <dbReference type="CTD" id="20317598"/>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53759" checksum="9F757746E219513E" modified="2014-10-01" version="1">MSVFKKLLGLDTQHQDAIESRPDVQPLGPYLQQKFSRGVNYNMKIVIRGDRTSGKTALFNRIKGGEFTETYVATNEIQVASVNWNYKNSGDIIKVEVWDVVDQGKPRPASQGLKLSNSPQSQKTEPCLDASFLDVYKGTHGVIIVMDMTKSWTFTYVRRELPRVPPHLPVLVLASHRDMGDKRTVTEDQVRAFLEEEAECRAASGEFPVSKSPKRAFRVQYCEASMLNGFGLRYVHKFFSLPFLCLQHTVLRQQLARNEMETSHVVAELETDGNAISTNQSAYEAYVQARREKQRVVLTHCSPPESSITTSSNTPAPVCTARGVSVQATALLHQATSDVRRGPTSSTDTAVQHTAHTPNRCSTKKTSCETAPEDTEAFIMVVGDTRAVRSNAARQCGLLDCRRSITNRSDVGSAGLSDDVTSTGDETFAIQLPSSANRPTTKVIHFPCISIQRQQSINKRPWITLTMLPYKVTEILEKESSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWL9</accession>
    <name>A0A074ZWL9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164756.1">
        <property type="nucleotide sequence ID" value="XM_009166492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWL9"/>
    <dbReference type="STRING" id="6198.A0A074ZWL9"/>
    <dbReference type="GeneID" id="20316476"/>
    <dbReference type="KEGG" id="ovi:T265_02288"/>
    <dbReference type="CTD" id="20316476"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000031">
        <property type="entry name" value="cyclin-L1-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="637" mass="71652" checksum="AEFCE51C9F81F200" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXR7</accession>
    <name>A0A074ZXR7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164374.1">
        <property type="nucleotide sequence ID" value="XM_009166110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXR7"/>
    <dbReference type="GeneID" id="20316160"/>
    <dbReference type="KEGG" id="ovi:T265_01972"/>
    <dbReference type="CTD" id="20316160"/>
    <dbReference type="OrthoDB" id="5947018at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="871" mass="101258" checksum="5F74DA712D595639" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZH1</accession>
    <name>A0A074ZZH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_02329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164807.1">
        <property type="nucleotide sequence ID" value="XM_009166543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZH1"/>
    <dbReference type="GeneID" id="20316517"/>
    <dbReference type="KEGG" id="ovi:T265_02329"/>
    <dbReference type="CTD" id="20316517"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF163">
        <property type="entry name" value="HISTAMINE H2 RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="55985" checksum="9DB7D7A7DD69524E" modified="2014-10-01" version="1">MDPPLRLEYIALCLIPLGTIWGNICVCLAVYLERRLRHRFNLFLVSLAISDLLCAILVMPVSAWHMIATRPQNRILCLVSYSMDIFFTATTIIHLCSISLDRYLALRRPFGRNRAVPKIFQSLVFRIFMSWFVPFSIAGPLFVFALKWERGDEEFIVTMTPESANITTSKSYKGCGPNDKSFVLTAIGVTFVLPLIIMTATYVLTVKMLRRHMAQVKAIQLYATRPRPVSTSSVLWLRRDNSFRPTEINRSTKAWFRQADQQSTIPKTTKYMPASDSGCDEKTVKTCSLSDPLSYHNRPAENPPRRIPIGVENPSTQDEASLSGNRVCGKDPSDKSNDQQSYVKASETLFLTSTAKNDHDISGLELSSNHELGLPSQGRRTDISSAQTTTAIDRIHSGKRAVRVIAVLFGLFVTCYTPFFIVYTISVVCPQCRSWAEPAIPHLEWLGYLNSMLNPVVYHSFNSTFRRTFRRIFQCACRTPHEHHAIWRSRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Q4</accession>
    <name>A0A075A0Q4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Zinc-hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_00786</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162922.1">
        <property type="nucleotide sequence ID" value="XM_009164658.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A0Q4"/>
    <dbReference type="GeneID" id="20314974"/>
    <dbReference type="KEGG" id="ovi:T265_00786"/>
    <dbReference type="CTD" id="20314974"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="20">
        <location>
            <begin position="672"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="215"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="429"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="787"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="897"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1004"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1107"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KER33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1376" mass="157109" checksum="7BF6AD558C5F402B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A134</accession>
    <name>A0A075A134_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596994">
        <property type="protein sequence ID" value="KER21109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175151.1">
        <property type="nucleotide sequence ID" value="XM_009176887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A134"/>
    <dbReference type="GeneID" id="20329332"/>
    <dbReference type="KEGG" id="ovi:T265_15167"/>
    <dbReference type="CTD" id="20329332"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="38326" checksum="7FBCA33952E27980" modified="2014-10-01" version="1" fragment="single">MREHSSVSLSGSGKKPGSSAIASRLAETTHFMDKEQAFNIIYREKGWRSQNDFIDWNSFANSTIKGNFIVISGDRMVRQAELQTLMFRFHSAYYKAAVCSVVKKILQRRHGSSANQSRKRRNIDGVSLEKCWLTSQRRDSARFQLTVGYSQDEHGTYTTPTEAPEEEVNITYLETSQTRDSAGVQKNRILYAPKEEVAHVQHIQLEEIINERFSWDLAECSVKIRLLCNLGHLNGKFLLGSFTDFVHLCSSKGAGTISLGMRVGWLIGSNATWISVLLDPGDVADNCTPPREISADLRPLSKRLQVLPPLFYSHWDAWRFPPPRPPVAVADQNTVPLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1W9</accession>
    <name>A0A075A1W9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1W9"/>
    <dbReference type="STRING" id="6198.A0A075A1W9"/>
    <dbReference type="GeneID" id="20314758"/>
    <dbReference type="KEGG" id="ovi:T265_00570"/>
    <dbReference type="CTD" id="20314758"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="376" mass="41904" checksum="2F82151209F903F0" modified="2014-10-01" version="1">MAEDEINALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQPGIMIGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKIMTERGHSFTTTAEREIVRDIKEKLCYVALDFDHEMATASESSSLEKGYELPDGQVITIGNERFRCPEAMFQPSFLGMECAGLHETAYTSIMKCDVDIRKDLYANIVLSGGSTMFPGIADRMQKEITLLTPSTMKIKIIAPPERKYSVWIGGSILASLSTFHQMWITKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A242</accession>
    <name>A0A075A242_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162487.1">
        <property type="nucleotide sequence ID" value="XM_009164223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A242"/>
    <dbReference type="GeneID" id="20314638"/>
    <dbReference type="KEGG" id="ovi:T265_00450"/>
    <dbReference type="CTD" id="20314638"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9377" checksum="F7A72C3241CCE5B5" modified="2014-10-01" version="1">MEELLFADGTANKHQDDSRTPRLLRLVKGHKTPPEYKSSNNLRASRDLGYFASTSSKVTLHTDLPSADSVSVHPLALHNKSKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2N1</accession>
    <name>A0A075A2N1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_00503</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162571.1">
        <property type="nucleotide sequence ID" value="XM_009164307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2N1"/>
    <dbReference type="STRING" id="6198.A0A075A2N1"/>
    <dbReference type="GeneID" id="20314691"/>
    <dbReference type="KEGG" id="ovi:T265_00503"/>
    <dbReference type="CTD" id="20314691"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000053">
        <property type="entry name" value="potassium voltage-gated channel subfamily A member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="574" mass="65715" checksum="054C5883FC0AB98C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A305</accession>
    <name>A0A075A305_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596943">
        <property type="protein sequence ID" value="KER21769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174507.1">
        <property type="nucleotide sequence ID" value="XM_009176243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A305"/>
    <dbReference type="GeneID" id="20324174"/>
    <dbReference type="KEGG" id="ovi:T265_10006"/>
    <dbReference type="CTD" id="20324174"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9192" checksum="432D1E323FE2789F" modified="2014-10-01" version="1">MSSSEIRFQGRTQGGVLAKQTDQLVNGKRQKRHLEFMDNLEAFGRMYDITAQYVLHFESAAVHSDLFPCKQLLEFGLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A383</accession>
    <name>A0A075A383_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166161.1">
        <property type="nucleotide sequence ID" value="XM_009167897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A383"/>
    <dbReference type="GeneID" id="20317600"/>
    <dbReference type="KEGG" id="ovi:T265_03413"/>
    <dbReference type="CTD" id="20317600"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15341" checksum="CF8E5A4A792EAE1D" modified="2014-10-01" version="1">MCGVKLSTPVPIVLGESEGCDDITNIHSDCVPDDVCGRHKLFPLLDDCRFSHMLRKCLRYEVRHARTSRETEYAKSGIAISDVHGSSVEPLQRRPAKNWQIRTLAPGSLVMGYLNRAGHQDIHRKLPTMFFRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A394</accession>
    <name>A0A075A394_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165401.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A394"/>
    <dbReference type="GeneID" id="20326950"/>
    <dbReference type="KEGG" id="ovi:T265_12782"/>
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    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ligand-gated calcium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1516"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1605"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="9">
        <location>
            <begin position="699"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1871"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1886"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1906" mass="217592" checksum="D7484E55222E95A9" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3C5</accession>
    <name>A0A075A3C5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176067.1"/>
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    <dbReference type="STRING" id="6198.A0A075A3C5"/>
    <dbReference type="GeneID" id="20324033"/>
    <dbReference type="KEGG" id="ovi:T265_09865"/>
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    <dbReference type="OrthoDB" id="10028852at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903723">
        <property type="term" value="P:negative regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033207">
        <property type="entry name" value="CCP110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594:SF1">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
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        </location>
    </feature>
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        <location>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER21909.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127622" checksum="9819268DCF053BF9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3P5</accession>
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        <recommendedName>
            <fullName evidence="4">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">T265_01181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3P5"/>
    <dbReference type="STRING" id="6198.A0A075A3P5"/>
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    <dbReference type="KEGG" id="ovi:T265_01181"/>
    <dbReference type="CTD" id="20315369"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43091" checksum="B2B3F21712F6002C" modified="2014-10-01" version="1">MCSAPVSGILMDQIGLRITKLVGVSLYFIGCLMFAFVRGGTSYLIFPAMIFGAVGAYASVLCNLHVASVFPVWRGMIISGLNGAYESSSVFAFVIAKTSPAFALRDSFILLGCFAFGAGCLVSTFILTQRTTDMRKLAKHATPNASTPEFAEEEEDSVYDREVERLIQYYYPDKKSCFLSEAYTMAYLYFLPGVLRFSLYFSQLDQQLLYSFTHEHEVVNKLLLASSYTSMCAILLSPFTGLVIDYSRKVARQKLESKLAVNNLKPRRIYWYHMCALAPTLFLLATLSFYISCTLYITGQQWVYYTQFVAIVFMGSILPSVTNTFIMTAFPLKYFGTLMGVLSLIGGIFSLVQFGLIQLPIAIGNGFMVVSSVIMFIPPIFLFIGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4B9</accession>
    <name>A0A075A4B9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161976.1">
        <property type="nucleotide sequence ID" value="XM_009163712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4B9"/>
    <dbReference type="STRING" id="6198.A0A075A4B9"/>
    <dbReference type="GeneID" id="20314243"/>
    <dbReference type="KEGG" id="ovi:T265_00055"/>
    <dbReference type="CTD" id="20314243"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="9">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="10">
        <location>
            <begin position="171"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="38187" checksum="BEC11811B7903398" modified="2014-10-01" version="1">MLPVRGRVLCGRSLAQGTLSVPIILSLSCLAICQRIKAEVNRLIAEFNVSPKLTVIEVGNRSDSALYIESKRRFADQCGVELAHVHLPPDCTESSLIELVKQFNTDPTVHGIMIQLPLDSIDPIDVSGPLHSIVAQKDVEGLGYMNTALLSRENVLFQPGVSPKDYPVHIPCTAAACFAFIRYVDFPLKGSHCVVIGRGRLVGAPTADLLAGPGCATVTQCNIHSQNLAEEVSRADLVVAAVGRPALVRGEWIKPGALVLDCGYTVVQDPLNPAKMTSVGDVSFEEARKRAGWITPVPGGIGPLNIAMLFRNTVNSARWSVGLQSLLFDSIFTRSSKVHSEVDQYCLERPLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Q5</accession>
    <name>A0A075A5Q5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165346.1">
        <property type="nucleotide sequence ID" value="XM_009167082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5Q5"/>
    <dbReference type="GeneID" id="20316955"/>
    <dbReference type="KEGG" id="ovi:T265_02767"/>
    <dbReference type="CTD" id="20316955"/>
    <dbReference type="OrthoDB" id="6252293at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="62480" checksum="FD8FE9E75A671A3A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5S2</accession>
    <name>A0A075A5S2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173493.1">
        <property type="nucleotide sequence ID" value="XM_009175229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5S2"/>
    <dbReference type="GeneID" id="20323395"/>
    <dbReference type="KEGG" id="ovi:T265_09216"/>
    <dbReference type="CTD" id="20323395"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9303" checksum="C7A600F08955E006" modified="2014-10-01" version="1" fragment="single">GCPWDHLVSYLQDGRHPLSPPLWQVRGPNSIHCQRTSHPVSNYVFSSSSFHLFPLSVWYEIVQLICKGVNRYDSNKYRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5T6</accession>
    <name>A0A075A5T6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_09199</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="14">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596880">
        <property type="protein sequence ID" value="KER22794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173475.1">
        <property type="nucleotide sequence ID" value="XM_009175211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5T6"/>
    <dbReference type="STRING" id="6198.A0A075A5T6"/>
    <dbReference type="GeneID" id="20323378"/>
    <dbReference type="KEGG" id="ovi:T265_09199"/>
    <dbReference type="CTD" id="20323378"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="17">
        <location>
            <begin position="152"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER22794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="374" mass="41171" checksum="D50F9605BA77A21E" modified="2014-10-01" version="1">MATATNHDGVRRQTTLLPVVSVASQLTLLIGGVSIIDFHIAVIAAAMGPARCVEKIFRRVHQLPASPPTGQLNELALMLIMIGPWRTSRVYHACYSWKGLRSSVWTRVLVAGGVVTVGVTALALPVFASEMQAHPAALPWCHNGILSTYDHAAVRRGYQVYKEVCSACHSMQYLAYRHLVNAVLTEDEAKADASEIQVTDGPDDKGDMFQRPGRLSDTLPSPYPNVEASRAANNGAAPPDLTYVVKARHGKEDYVFHLLTGYCEPPAGRNVAEGQYYNPYFPGGAISMARPLYDDMIQYADGTPATTSQMAKDVVSFLCWSSDRNHDQRKRFLFKALIVMAIAVAVVGVAKRKRWSNIKSRKLVYKNRPMPKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A652</accession>
    <name>A0A075A652_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165095.1">
        <property type="nucleotide sequence ID" value="XM_009166831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A652"/>
    <dbReference type="GeneID" id="20316740"/>
    <dbReference type="KEGG" id="ovi:T265_02552"/>
    <dbReference type="CTD" id="20316740"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="24532" checksum="0CD41F5F78EABE31" modified="2014-10-01" version="1">MGSREEEAGFETRSFRKIRRTLEGFKNPGTRTADDKNPVNLECVDKIVLNQKNAQTCSHLTRRLQSKERHSKLLSALRALEVILVPVRNCCCNGLNRYQVPAYVRFLSIPRNGHANLTSSNNHSSTVSVLAKSTTFCCKPYCTGSEHVGEARRNVKRAMLAALSAVYPTSRPQDYWILSRSLVLIDTRKSITVGREDDGARKCLKPQVVKSLEKDRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6F9</accession>
    <name>A0A075A6F9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165049.1">
        <property type="nucleotide sequence ID" value="XM_009166785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6F9"/>
    <dbReference type="GeneID" id="20316710"/>
    <dbReference type="KEGG" id="ovi:T265_02522"/>
    <dbReference type="CTD" id="20316710"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12732" checksum="D80697A5A4609D71" modified="2014-10-01" version="1">MIVITAIDWRDNRFLPIREEIAFVKRLTKRTCIILDTSDDVMKETRNIIFGFMNKYKLSFRPILTDQTSAPFRHLGGTEVKYTDLTLSTNTGILYLSFETSGMVVCDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A709</accession>
    <name>A0A075A709_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Variant SH3 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173076.1">
        <property type="nucleotide sequence ID" value="XM_009174812.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A709"/>
    <dbReference type="GeneID" id="20328859"/>
    <dbReference type="KEGG" id="ovi:T265_14693"/>
    <dbReference type="CTD" id="20328859"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12012">
        <property type="entry name" value="SH3_RIM-BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12013">
        <property type="entry name" value="SH3_RIM-BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000023">
        <property type="entry name" value="RIMS-binding protein 2 isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000016">
        <property type="entry name" value="RIMS-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035753">
        <property type="entry name" value="RIM-BP_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035755">
        <property type="entry name" value="RIM-BP_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1500"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1193"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1335"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1736" mass="192611" checksum="E0CD9C2B4ACDD022" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7R8</accession>
    <name>A0A075A7R8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164491.1">
        <property type="nucleotide sequence ID" value="XM_009166227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7R8"/>
    <dbReference type="STRING" id="6198.A0A075A7R8"/>
    <dbReference type="GeneID" id="20316256"/>
    <dbReference type="KEGG" id="ovi:T265_02068"/>
    <dbReference type="CTD" id="20316256"/>
    <dbReference type="OrthoDB" id="6266590at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="296" mass="32613" checksum="A7D6DCA729BCF8FC" modified="2014-10-01" version="1">MPDTSSIRRPRLTPATKYELTVSAATRGGNGPDSPLVTFTTEAREAEVDRGSQQTDAGYIMSGDNAGNHPNVGERSPLSSDRGKLSSHLRAVENLRYIDDEENLLLLWSPPVNSKSLSGSDSLAMEIDHYLIKWGKLYPGPNIARVAADQSRFLIDNLALTPFWCHPFAKSPKGSTRAGILLGCLSLDRGIPDAEVGFESQTVWSVNALSHRASPFCHPKEARGLGYYRGIPDAEVGFESQTVWSMCQISKRDPNLADSCIELISNAKIRTTTTSKIHKTFHSIHYLSLVCKWRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7S4</accession>
    <name>A0A075A7S4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164499.1">
        <property type="nucleotide sequence ID" value="XM_009166235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7S4"/>
    <dbReference type="STRING" id="6198.A0A075A7S4"/>
    <dbReference type="GeneID" id="20316264"/>
    <dbReference type="KEGG" id="ovi:T265_02076"/>
    <dbReference type="CTD" id="20316264"/>
    <dbReference type="OrthoDB" id="6273360at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="29558" checksum="613F21CED9AE5970" modified="2014-10-01" version="1">MNSWMNAIMSLIQGGGGGYQPPGPPMGSMPPYSTPQGMPAMPSMPGTIGFGGFADAPPQYSPQPQAPAYGSYQQQPGYNSGPAYNYPTGSYCQPQVPLAPAATYGGGGAYPRQPPPPPGQTSYYTPPSAGQQFVGSNGQPYEVVYVGGKPKKKKLLKNAAVGLASGLAGGYLASKVFGGGGWCRPWGGGWGGGWGMGRWGSWSSFSSLIDLSIRITNRRSNRPSTKAHSPFYWRLFSSLLAFNQFMTSDPYQSKAHYCPSVAKHSNTYFDFLLSQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A851</accession>
    <name>A0A075A851_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164373.1">
        <property type="nucleotide sequence ID" value="XM_009166109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A851"/>
    <dbReference type="STRING" id="6198.A0A075A851"/>
    <dbReference type="GeneID" id="20316159"/>
    <dbReference type="KEGG" id="ovi:T265_01971"/>
    <dbReference type="CTD" id="20316159"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7358" checksum="50F6A989F17723C6" modified="2014-10-01" version="1">MKIGNLHYRRGVITYSLSPYEQNAFAGFFKHGFPNLMRRFREKVWIVAPRSEPSKAMSVGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A865</accession>
    <name>A0A075A865_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164395.1">
        <property type="nucleotide sequence ID" value="XM_009166131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A865"/>
    <dbReference type="STRING" id="6198.A0A075A865"/>
    <dbReference type="GeneID" id="20316181"/>
    <dbReference type="KEGG" id="ovi:T265_01993"/>
    <dbReference type="CTD" id="20316181"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30139" checksum="864F7E17CEE048C0" modified="2014-10-01" version="1">MWKKPEKPKPTSTLRSHEPIECCELKDISRCGICEDLNATTRNAILNLIKQVERQKKLHFNKTELSILLHMCVEITGREVRDMTVDELKTFLYGTLDITNPFSLDGLCRASMQSTKHSATKKTVSPIDFVCLMSVLLRGTIGERAEVAFRIMDLDSDGLIRRNVEVRRLLHDSFDVSVAAQNPEIDPDEPVRDTINYLCEKLQCTLTQPISLDRFKTLAYEEPWIVECLLPCIPSEMTNLVFQTLISTHVRLPSLENPPKIARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A874</accession>
    <name>A0A075A874_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164322.1">
        <property type="nucleotide sequence ID" value="XM_009166058.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A874"/>
    <dbReference type="GeneID" id="20327051"/>
    <dbReference type="KEGG" id="ovi:T265_12883"/>
    <dbReference type="CTD" id="20327051"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1529" mass="164994" checksum="E17499A8834B398B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9H6</accession>
    <name>A0A075A9H6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163940.1">
        <property type="nucleotide sequence ID" value="XM_009165676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9H6"/>
    <dbReference type="GeneID" id="20315805"/>
    <dbReference type="KEGG" id="ovi:T265_01617"/>
    <dbReference type="CTD" id="20315805"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11234" checksum="979D06985AD0EBCC" modified="2014-10-01" version="1">MMVLMSPLNGMHKARDGTHREATEKPHVGIAASEEDVTISVKGKTFVLMTTWLMWIWYKKLMVGITVLHERLSVQSLYNEKEYNAPSMITGVAPITKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAX1</accession>
    <name>A0A075AAX1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163264.1">
        <property type="nucleotide sequence ID" value="XM_009165000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAX1"/>
    <dbReference type="GeneID" id="20315245"/>
    <dbReference type="KEGG" id="ovi:T265_01057"/>
    <dbReference type="CTD" id="20315245"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6907" checksum="4CFF9116415BE76B" modified="2014-10-01" version="1">MNNCARTGGRLFKTRVICSNFALIKAMGLPLLHRCTQDESGFPHMNRRTCSRLSNVIGSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACL6</accession>
    <name>A0A075ACL6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170720.1">
        <property type="nucleotide sequence ID" value="XM_009172456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACL6"/>
    <dbReference type="GeneID" id="20321211"/>
    <dbReference type="KEGG" id="ovi:T265_07032"/>
    <dbReference type="CTD" id="20321211"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="10198" checksum="FBA0244482EA0EEE" modified="2014-10-01" version="1">MHQVFDRRCLRPVDRVRGHHCIGNAESLMDKRVEENKQFNGFECPSELQAFTLCYPIFDNASKLRKPFPNFRHYQSLPMVTRMLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACW7</accession>
    <name>A0A075ACW7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170563.1">
        <property type="nucleotide sequence ID" value="XM_009172299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACW7"/>
    <dbReference type="GeneID" id="20321080"/>
    <dbReference type="KEGG" id="ovi:T265_06901"/>
    <dbReference type="CTD" id="20321080"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="302" mass="34134" checksum="F4577B867A4F8F6A" modified="2014-10-01" version="1">MDLKHPPASCCLQTNVTNKQFYADPSGDYPPMTDVTAEHIERLSVLDHRCLQSIALIQWEHRISNAEVRRVALVLQCAPYASQLTSSKGSFRSTIRRVEMSKGCSNNDLTVMYGSCYQKTHFRLSLLSSWFGTPSRNTSMIGDFFRHGPVAPSMALVHPSHCFQFMASLPISSIKSPVTTLYLCINCISFRLQYTAIYLPLQIISERNCGSYNHCTTNMWFLQLLMIMSVGSSLLSRLNSKLPWILPEQMVNVRKQRNNEDKAAKMVGGTQRSHGILQLHSHGRRKIAHSILDTERVVKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADA2</accession>
    <name>A0A075ADA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170290.1">
        <property type="nucleotide sequence ID" value="XM_009172026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADA2"/>
    <dbReference type="STRING" id="6198.A0A075ADA2"/>
    <dbReference type="GeneID" id="20320871"/>
    <dbReference type="KEGG" id="ovi:T265_06692"/>
    <dbReference type="CTD" id="20320871"/>
    <dbReference type="OrthoDB" id="6279168at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16411" checksum="489908879A9970FE" modified="2014-10-01" version="1">MDRVVQGLDFVYAYIDDVPIAGRSEEEHVLHLKQVFERFQQYGIVINSKHESDWQHGCFDKIRRTLSFPTRQAAQQAKYVAHIDETLGDRAEGDRIQDKEAVYSIGAGIQRILAIRSRDSSRRRQCESEGDETEVQLQDCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEG6</accession>
    <name>A0A075AEG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169575.1">
        <property type="nucleotide sequence ID" value="XM_009171311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEG6"/>
    <dbReference type="STRING" id="6198.A0A075AEG6"/>
    <dbReference type="GeneID" id="20320307"/>
    <dbReference type="KEGG" id="ovi:T265_06125"/>
    <dbReference type="CTD" id="20320307"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="491"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70236" checksum="014621EAA471A329" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFI6</accession>
    <name>A0A075AFI6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">T265_05214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596714">
        <property type="protein sequence ID" value="KER27784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168433.1">
        <property type="nucleotide sequence ID" value="XM_009170169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFI6"/>
    <dbReference type="GeneID" id="20319396"/>
    <dbReference type="KEGG" id="ovi:T265_05214"/>
    <dbReference type="CTD" id="20319396"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="780" mass="88125" checksum="AC62D3B757EFC78A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFL3</accession>
    <name>A0A075AFL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.361</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_05161</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60344"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.361"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.361" evidence="3"/>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168357.1">
        <property type="nucleotide sequence ID" value="XM_009170093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFL3"/>
    <dbReference type="STRING" id="6198.A0A075AFL3"/>
    <dbReference type="GeneID" id="20319343"/>
    <dbReference type="KEGG" id="ovi:T265_05161"/>
    <dbReference type="CTD" id="20319343"/>
    <dbReference type="OrthoDB" id="5560686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140944">
        <property type="term" value="F:histone H4K20 monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043516">
        <property type="term" value="P:regulation of DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10528">
        <property type="entry name" value="SET_SETD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016858">
        <property type="entry name" value="KMT5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047266">
        <property type="entry name" value="KMT5A-like_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51571">
        <property type="entry name" value="SAM_MT43_PR_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="250"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER27879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="387" mass="44018" checksum="12B711BA1812FD68" modified="2014-10-01" version="1">MALAEKRRHPHYWHMADGGSPHLDNAKPHCISTPRVTKSSQAPIDGCEPSTTPAGDRSSGSLRQTTLCFSFIQSKDDDEVTVPMRDEDTQDNVEKSEEKPFQKSKKKTTTHGAVIPRDISEQDVSTISSPDIRLRRDTKQTLLPTKLTSSRQNGAAEIRVQKSSRVRSVDARPCPNSTRQLPRTKAASVSPKKNLPVEKIADTQRRTSAEKRQTKLTAYGIRRTARQYEKDKEREREINVLTSIRDEVESGMKIIITEEKGRGIVATRVFQEGEFVVEYAGDLIPEKIAKKREMEYKRDPSIGSYMFYFVHNGQRYCVDATQETPRLGRLINHSRLHPNCHVKVIPLDGIPRLVLFAKQMILPGEELLYDYGDRDKETLEAHPWLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG21</accession>
    <name>A0A075AG21_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167945.1">
        <property type="nucleotide sequence ID" value="XM_009169681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG21"/>
    <dbReference type="GeneID" id="20319017"/>
    <dbReference type="KEGG" id="ovi:T265_04835"/>
    <dbReference type="CTD" id="20319017"/>
    <dbReference type="OrthoDB" id="19988at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9526" checksum="E62D343742682443" modified="2014-10-01" version="1">MHRHTASNGEANEKPKQKLMGAKGHIYKVALTASYGSQINSGDRRSEQRLKSRQPTSRKDTQSSWTLKGLKIYDQKVGIWLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGT1</accession>
    <name>A0A075AGT1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4201 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167180.1">
        <property type="nucleotide sequence ID" value="XM_009168916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGT1"/>
    <dbReference type="GeneID" id="20318409"/>
    <dbReference type="KEGG" id="ovi:T265_04223"/>
    <dbReference type="CTD" id="20318409"/>
    <dbReference type="OrthoDB" id="6253495at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="43604" checksum="250B7A801780C071" modified="2014-10-01" version="1">MNVEKRESLCSSYSFAMTAKNNLLSEFTMENEVIEQRIKATRKKLDDCLQENAIYELFCEQIHGEPLELPSSDCSVRPSLGRIHKSVKTKGRFITLNMEQKCVVAKYALEERTKDLNLLRKEHESVAEQYEVLLKAQLERKIECAKTRSSFDLLVVQRTECLPGMPLELTGMNKFCRFHKFYLNRLDTQLSNMRIESVNSRNEIRRMKKSLRELEEPGRVIHSVEHEQLKIHCRNALREIQRLEMMCAHVKACATRIGSQLASLRLQLKQEMAKNEELEEETDRIFRMGTKLNFLVSKNEEGLQDDMFDHYRLKKYLVTYRVPTTSQYAHTLAEMAWLTRERLVMKRKERIAALTLQRYKKLWHHIQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGZ2</accession>
    <name>A0A075AGZ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167061.1">
        <property type="nucleotide sequence ID" value="XM_009168797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGZ2"/>
    <dbReference type="GeneID" id="20318325"/>
    <dbReference type="KEGG" id="ovi:T265_04139"/>
    <dbReference type="CTD" id="20318325"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22159" checksum="0C16B0D9E293522A" modified="2014-10-01" version="1">MTYTTNNILMPHRPSRGAISRVALLAAYSRTGKRKQATADAFLLSPSHTFSSPSPHPINNSLLVGPALRTDDSVRHASVLRAASARHMVPTSSGISRSVLKPRHPLYLAAFNVRTLKQAGQQAALALTLDSLGIDVCCVSETRIQDASTDRLPRRAPSSQLCAEWKKLRGWQSINWKRSMKTQFGLTYAASLDRDHGAQITSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH30</accession>
    <name>A0A075AH30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166951.1">
        <property type="nucleotide sequence ID" value="XM_009168687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH30"/>
    <dbReference type="GeneID" id="20318238"/>
    <dbReference type="KEGG" id="ovi:T265_04052"/>
    <dbReference type="CTD" id="20318238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12001" checksum="59D017F00C540FE0" modified="2014-10-01" version="1">MLTPVATSYIVTVVIHRRSNYANCELRKCCPKTAHDSPPVKLGPHKTKTCIIGKRQQMKDGIGYRLAKTVDSNQMGQMTKENERNFELDLSSNYKYEMCEQAGSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHB2</accession>
    <name>A0A075AHB2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166668.1">
        <property type="nucleotide sequence ID" value="XM_009168404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHB2"/>
    <dbReference type="GeneID" id="20327497"/>
    <dbReference type="KEGG" id="ovi:T265_13330"/>
    <dbReference type="CTD" id="20327497"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="24520" checksum="2CC28F831F03CC00" modified="2014-10-01" version="1" fragment="single">MKETTHKFAENSSIAPYSVLFLLQILNSAGGSSPPGSTEGSTKAEILPGFPSLGKTSRDMERFIRTQPTSTHGKTKDDLVLEGAVLTKYCLCTRHWKPTTAFFIGLQATFDPMNRCTPEELDISFVKRVFHQMLRSFVLSFSCHTHPMPSSHVTRRKNEGWDTVRLPKPRQANSRGRGRVRTPDLPFSKFSTFLLTHLTFSHGSIVVRMVALFVSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHD8</accession>
    <name>A0A075AHD8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166537.1">
        <property type="nucleotide sequence ID" value="XM_009168273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHD8"/>
    <dbReference type="GeneID" id="20317913"/>
    <dbReference type="KEGG" id="ovi:T265_03726"/>
    <dbReference type="CTD" id="20317913"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18825" checksum="ED8C617BFC6600BA" modified="2014-10-01" version="1">MKHPWSMQTLIGDFTTFLPRFDMPCAKSTKYNRRLNVAGAKSIPVPPKRLYCLVSEGSPKDVWRRRRWESWLSAAALRIGRHLKLKETINPCGYRGETFEPACCIYVCVRPGFVSLAKPDLKRNGIIKQSAARSICLSVSDYYQPMNLQPVKHCSEQEDFTVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIH5</accession>
    <name>A0A075AIH5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164592.1">
        <property type="nucleotide sequence ID" value="XM_009166328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIH5"/>
    <dbReference type="STRING" id="6198.A0A075AIH5"/>
    <dbReference type="GeneID" id="20316342"/>
    <dbReference type="KEGG" id="ovi:T265_02154"/>
    <dbReference type="CTD" id="20316342"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="48"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="731" mass="81969" checksum="A0CAD78EEF12C90B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIM6</accession>
    <name>A0A075AIM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164385.1">
        <property type="nucleotide sequence ID" value="XM_009166121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIM6"/>
    <dbReference type="STRING" id="6198.A0A075AIM6"/>
    <dbReference type="GeneID" id="20316171"/>
    <dbReference type="KEGG" id="ovi:T265_01983"/>
    <dbReference type="CTD" id="20316171"/>
    <dbReference type="OrthoDB" id="10028263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46331:SF2">
        <property type="entry name" value="VALACYCLOVIR HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36038" checksum="3AE791FA77EAE70E" modified="2014-10-01" version="1">MRINHRLLFGTLLRLERTGIEYIKSIGKMYHCGLFEVVQGYKIHYMRAGSGAHNLLLFPGPMGSVITDYSLFLDRLDKKTFTAIGWDPPGQGGSIPPTERSWLQQPGRLQEDAHLALRLMRHLNLVPFSLLGWAEGAITALITVANCEPKEFRKLVLWAHEGAIPCVKANLIDQTQDPHAWPLTCRAPLEAMYDSNYLAENWTHYTLAKNLGYFWRELGDPVIKRQLTEQFSTNSGPLLLLMRAPGRLNAEDWLTYILAQMDNVRIINWMNHEEVISSTEKYTCWGPHRADPDEFQAIAEHFLRCGQVKEPLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIW1</accession>
    <name>A0A075AIW1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163876.1">
        <property type="nucleotide sequence ID" value="XM_009165612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIW1"/>
    <dbReference type="GeneID" id="20315741"/>
    <dbReference type="KEGG" id="ovi:T265_01553"/>
    <dbReference type="CTD" id="20315741"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9454" checksum="23B8D46809B06FF4" modified="2014-10-01" version="1">MTDGMQRRQPDAAKKINLANPKAKNNGMDADKYTDTEKRLITYKIAGNFSTMVVGLFAELDKLLANVSPSIERGGGVVAVRRVVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJA6</accession>
    <name>A0A075AJA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163132.1">
        <property type="nucleotide sequence ID" value="XM_009164868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJA6"/>
    <dbReference type="STRING" id="6198.A0A075AJA6"/>
    <dbReference type="GeneID" id="20315141"/>
    <dbReference type="KEGG" id="ovi:T265_00953"/>
    <dbReference type="CTD" id="20315141"/>
    <dbReference type="OrthoDB" id="6233288at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11423">
        <property type="entry name" value="bHLH_TS_musculin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000010">
        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF72">
        <property type="entry name" value="HLH54F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="366" mass="40726" checksum="E39DDAAE9BDC571F" modified="2014-10-01" version="1">MSDSLLVTSGGKRRGRKPGLNSTVAQRSAANARERSRMRVLSGAFVELKGALPWVPKDTKLSKLDTLKLAAGYIAYLRRILDTASDSDDSPQEDGLTCSNSPEKSLSLFSLTTHTGQSLKSCLETSRLQHFRTAHDRSVSESEFYPGRATCELGSSLCQEIRPFLGIPSDCIYSEDIFSNENKASRNKEVVPESKFGSTPPQDHCLSTVHSKNSWQNYHCSNKGETCDLTRWLSIHSAEQDGRFDFDNKTFNISASESPDYLGDRPEHAVSHFHPLMREHITSSYGSEAAVLNTELSRLLSPTIKTLWSTNRLDDMCPDVSHLSQMKYTTDFLNSSQSVYPIGDINADRLFTAVGAKYPEAYFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJE5</accession>
    <name>A0A075AJE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163090.1">
        <property type="nucleotide sequence ID" value="XM_009164826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJE5"/>
    <dbReference type="GeneID" id="20315119"/>
    <dbReference type="KEGG" id="ovi:T265_00931"/>
    <dbReference type="CTD" id="20315119"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9631" checksum="254F53A30211E90D" modified="2014-10-01" version="1">MWIALSGPSGTIHLNSDFKELLEVSSNLVVSADETGTAGLQVTPQLPAIWRRDQDKDADPVATTLWIPTGYCKLTDMGTFRIRISNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVB0</accession>
    <name>A0A074YVB0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598811">
        <property type="protein sequence ID" value="KER18671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177582.1">
        <property type="nucleotide sequence ID" value="XM_009179318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVB0"/>
    <dbReference type="GeneID" id="20326364"/>
    <dbReference type="KEGG" id="ovi:T265_12196"/>
    <dbReference type="CTD" id="20326364"/>
    <dbReference type="OrthoDB" id="10571009at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="14197" checksum="B8E5531EB40A1888" modified="2014-10-01" version="1">MLFSTEALIGLSEQWAKPFPSIWSLTFSKRRSCHLLVQHYINWPSFLHQSHPSAARLGYVCRFYCDRLHFFPSVKPHFVIEAGDAADTVKQQEQKEQMITTCSTETITFHRTDLSQETAQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWF3</accession>
    <name>A0A074YWF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597336">
        <property type="protein sequence ID" value="KER19096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177157.1">
        <property type="nucleotide sequence ID" value="XM_009178893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWF3"/>
    <dbReference type="GeneID" id="20326179"/>
    <dbReference type="KEGG" id="ovi:T265_12011"/>
    <dbReference type="CTD" id="20326179"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="34" mass="3531" checksum="BAA2A67A69F01DFD" modified="2014-10-01" version="1" fragment="single">VQGEDFGHLAAGPDDIPLALSKDDVGFPGERPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY06</accession>
    <name>A0A074YY06_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597162">
        <property type="protein sequence ID" value="KER19646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176602.1">
        <property type="nucleotide sequence ID" value="XM_009178338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY06"/>
    <dbReference type="GeneID" id="20329650"/>
    <dbReference type="KEGG" id="ovi:T265_15485"/>
    <dbReference type="CTD" id="20329650"/>
    <dbReference type="OrthoDB" id="6321430at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="270" mass="30031" checksum="130A8C328F7DC502" modified="2014-10-01" version="1" fragment="single">MAQPHGPPLVNPSRCSAIAAWQGRLGRFPCQMHQVLHTELASCSRQSHMGPKRRQNTFDELVRQQLLARHSVQFRKSPIQRLMQAGEEHHGVASRSDPGCLELPHSLPAVGRTQMSSPSSLSADSNSFIYSKRDSYGSNWKLPSASYAANVTGQQLQKDKLKPLSMKKIVVAFQCGPLSAQNVLSLLKLDELFENRRWCSTPCGYFLLPQYGSNWKLPSASYAANVTGQQLQKDKLKPLSMKKIVVAFQCGPLSAQNVLSLLKLDELFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYN7</accession>
    <name>A0A074YYN7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603811">
        <property type="protein sequence ID" value="KER18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177946.1">
        <property type="nucleotide sequence ID" value="XM_009179682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYN7"/>
    <dbReference type="GeneID" id="20326483"/>
    <dbReference type="KEGG" id="ovi:T265_12315"/>
    <dbReference type="CTD" id="20326483"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8469" checksum="8BCDDD41C167190C" modified="2014-10-01" version="1">MLRGPQAINASETGKNTKGITLSLCSMEFQKRLKCVPKPQLNLRISNEPDEEAGWIIPAEFTCAFPKLHLLLSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0B1</accession>
    <name>A0A074Z0B1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597052">
        <property type="protein sequence ID" value="KER20476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175771.1">
        <property type="nucleotide sequence ID" value="XM_009177507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0B1"/>
    <dbReference type="STRING" id="6198.A0A074Z0B1"/>
    <dbReference type="GeneID" id="20325146"/>
    <dbReference type="KEGG" id="ovi:T265_10978"/>
    <dbReference type="CTD" id="20325146"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="97282" checksum="861F85AB812C3003" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z177</accession>
    <name>A0A074Z177_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175552.1">
        <property type="nucleotide sequence ID" value="XM_009177288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z177"/>
    <dbReference type="GeneID" id="20324980"/>
    <dbReference type="KEGG" id="ovi:T265_10812"/>
    <dbReference type="CTD" id="20324980"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14968" checksum="E2DBB68DA93BD3F4" modified="2014-10-01" version="1">MRMSEDHSLEAQKLDRKSPRGETRNGLLLGPRAANPKITAKLMAVIGHCSLESRRYHRSCSDLQLLILTVAESSITEGSDTQLETAKHTSQLLWYGVFTQVRKDDNFIHIGANQMFWESIILVYPKLRGAGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1D4</accession>
    <name>A0A074Z1D4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597014">
        <property type="protein sequence ID" value="KER20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175391.1">
        <property type="nucleotide sequence ID" value="XM_009177127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1D4"/>
    <dbReference type="GeneID" id="20324842"/>
    <dbReference type="KEGG" id="ovi:T265_10674"/>
    <dbReference type="CTD" id="20324842"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="17571" checksum="DA7DE81FFCF16303" modified="2014-10-01" version="1">MEVGRNHPIDSPDKSSRVVSEGEMSEGEREILITEGPILMDTQIASPLAEAVPEAKRPNNRRVYSDYPYIKHKDLFHKSGAPRNRMKEESIYSEEIPDCEETMGFHFVIDTIMEAALPASNACGVDVLPGRSLTNIEYADTQLFLDLTPWQFKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1G1</accession>
    <name>A0A074Z1G1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597244">
        <property type="protein sequence ID" value="KER19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176928.1">
        <property type="nucleotide sequence ID" value="XM_009178664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1G1"/>
    <dbReference type="GeneID" id="20326033"/>
    <dbReference type="KEGG" id="ovi:T265_11865"/>
    <dbReference type="CTD" id="20326033"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11201" checksum="BCC7170DC92FA25F" modified="2014-10-01" version="1">MNRKLPKRIRRLLEKRSQLFFKKLTTGDTEDELAFRKMRNRCNQLLLSMRELVSQVTFILEPASSATLVSRISLTAHCNSASPATTCPYYIFTPLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1V4</accession>
    <name>A0A074Z1V4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175217.1">
        <property type="nucleotide sequence ID" value="XM_009176953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1V4"/>
    <dbReference type="GeneID" id="20324719"/>
    <dbReference type="KEGG" id="ovi:T265_10551"/>
    <dbReference type="CTD" id="20324719"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="130" mass="14812" checksum="7FEA3C8081C9A4CD" modified="2014-10-01" version="1">MCIHAPHNVAPALSTAQPDRATECAAPGRKREIQLGSRLRTDFSPPSRKKTKKKGVLRSNQLVDRTFVCRLASSRQQIRFLHERLRQNARGVFYKSPLNAIRFLSSANRPAVKQRTGATYIPHHQQTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1V9</accession>
    <name>A0A074Z1V9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597197">
        <property type="protein sequence ID" value="KER19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176774.1">
        <property type="nucleotide sequence ID" value="XM_009178510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1V9"/>
    <dbReference type="STRING" id="6198.A0A074Z1V9"/>
    <dbReference type="GeneID" id="20325930"/>
    <dbReference type="KEGG" id="ovi:T265_11762"/>
    <dbReference type="CTD" id="20325930"/>
    <dbReference type="OrthoDB" id="6274754at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15561" checksum="5BAE8CF0FF11721B" modified="2014-10-01" version="1">MADIDCWSEEEAAETVLKCLYTDCLSHFNKLCDANQSACLDKPSIIAPTETWLTPDVSDAEVSIDGYSILRADSKRGRAGGVALYLHAALPIPIVLSDTIPAPFCDALWVQIPLRGSDSLLLGVVYRSPSSPPEDHQFLIQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2N7</accession>
    <name>A0A074Z2N7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174928.1">
        <property type="nucleotide sequence ID" value="XM_009176664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2N7"/>
    <dbReference type="STRING" id="6198.A0A074Z2N7"/>
    <dbReference type="GeneID" id="20324496"/>
    <dbReference type="KEGG" id="ovi:T265_10328"/>
    <dbReference type="CTD" id="20324496"/>
    <dbReference type="OrthoDB" id="10607927at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="20488" checksum="B599B7226EB11133" modified="2014-10-01" version="1">MNLSWKQLGSGVELVVFAVNGTSGREGTVDRRNGIVEAPLFRDDHSSSRLESVQRSFTKQLFPRSNPLSYRSRCQTLGFKPLWLRQFKMNRTLFHRLMHKNPFIAEFRLNVNSRPRYRFRNSCNLVVPTSSYKRNYHFTASSATCLYRRLFAVCLSELTELFLLVMLSPRLEKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Y0</accession>
    <name>A0A074Z2Y0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596973">
        <property type="protein sequence ID" value="KER21353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174899.1">
        <property type="nucleotide sequence ID" value="XM_009176635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Y0"/>
    <dbReference type="GeneID" id="20324474"/>
    <dbReference type="KEGG" id="ovi:T265_10306"/>
    <dbReference type="CTD" id="20324474"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15967" checksum="AD4D5C1A0F22122E" modified="2014-10-01" version="1">MSKRKHMFFPGSLNATWRTDSKRTKTYRMYGAISLLWSLSANHEHGNERSSLIGSFGAVMARAEIVAFRDEGRHGRTKDYLKGSFTLSSYPISMRLVKPTKKYKNAHLYSFTQYKRGHVFRLSSDFAHAYSGHFASLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z480</accession>
    <name>A0A074Z480_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597068">
        <property type="protein sequence ID" value="KER20322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175933.1">
        <property type="nucleotide sequence ID" value="XM_009177669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z480"/>
    <dbReference type="GeneID" id="20325271"/>
    <dbReference type="KEGG" id="ovi:T265_11103"/>
    <dbReference type="CTD" id="20325271"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="18641" checksum="55417B4E66C6FAF6" modified="2014-10-01" version="1">MTDMEILHTKAPIRSTGCARFSLVNELSAHSQMTSEWNTPSTGEPADLKIEHSYSQLSWCDGVPVWSARFVIDSFQTYPLMCTISGACSSVVSACLTTLLQSRSELYPDHLSTILGSFSVISVRFLRQGGTGEQRCSLQMYAIRAPCAHQASAAKPSVLGERAFKSIDGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4H4</accession>
    <name>A0A074Z4H4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174274.1">
        <property type="nucleotide sequence ID" value="XM_009176010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4H4"/>
    <dbReference type="STRING" id="6198.A0A074Z4H4"/>
    <dbReference type="GeneID" id="20329130"/>
    <dbReference type="KEGG" id="ovi:T265_14964"/>
    <dbReference type="CTD" id="20329130"/>
    <dbReference type="OrthoDB" id="72033at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057478">
        <property type="entry name" value="DAAF9_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056414">
        <property type="entry name" value="DAAF9_CobW_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056498">
        <property type="entry name" value="DAAF9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040342">
        <property type="entry name" value="DNAAF9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055512">
        <property type="entry name" value="DUF7085"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664">
        <property type="entry name" value="RCG26366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23319">
        <property type="entry name" value="CobW_C_DAAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25204">
        <property type="entry name" value="DAAF9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23281">
        <property type="entry name" value="DAAF9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23318">
        <property type="entry name" value="DUF7085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAAF9 N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7085" evidence="2">
        <location>
            <begin position="438"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9" evidence="4">
        <location>
            <begin position="771"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9 CobW C-like" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134935" checksum="C29367B4E5AF1FF1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4N0</accession>
    <name>A0A074Z4N0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597052">
        <property type="protein sequence ID" value="KER20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175777.1">
        <property type="nucleotide sequence ID" value="XM_009177513.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z4N0"/>
    <dbReference type="GeneID" id="20325152"/>
    <dbReference type="KEGG" id="ovi:T265_10984"/>
    <dbReference type="CTD" id="20325152"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="2185"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="2307"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1672"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1732"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1901"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1952"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2031"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2412"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2586"/>
            <end position="2733"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="651"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="722"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="779"/>
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        </location>
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        <location>
            <begin position="1673"/>
            <end position="1688"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2536"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
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            <end position="2663"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2803" mass="307996" checksum="0A381BD4B3D995B0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4T3</accession>
    <name>A0A074Z4T3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603636">
        <property type="protein sequence ID" value="KER18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177938.1">
        <property type="nucleotide sequence ID" value="XM_009179674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4T3"/>
    <dbReference type="GeneID" id="20326480"/>
    <dbReference type="KEGG" id="ovi:T265_12312"/>
    <dbReference type="CTD" id="20326480"/>
    <dbReference type="OrthoDB" id="10528627at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17599" checksum="AB342D6DFCF10466" modified="2014-10-01" version="1">MVVIGMQNNVLVTSHITLVRVQTINTNSVDSFAWSVKIVLDNSSYCRLNIDKSHPVRHSSDTPLSWRVVPQNCPFEILDEISIETVDWVYYADPKKVSFAKLSPDQARRRMQSRVTTIYTAIKLLKRVFRLPVFHSQWMELENFGSSRRTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4Y0</accession>
    <name>A0A074Z4Y0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174124.1">
        <property type="nucleotide sequence ID" value="XM_009175860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4Y0"/>
    <dbReference type="GeneID" id="20323872"/>
    <dbReference type="KEGG" id="ovi:T265_09704"/>
    <dbReference type="CTD" id="20323872"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="8827" checksum="05D7A3DE40FFC367" modified="2014-10-01" version="1">MLFERLPCRRMAFAAEYHGQSLVPLVESSACSLPPNDIQPSATAAENNASVQAFTQRQVSSAKNSSNYLIGYLRGNSPPGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5E2</accession>
    <name>A0A074Z5E2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600252">
        <property type="protein sequence ID" value="KER18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177728.1">
        <property type="nucleotide sequence ID" value="XM_009179464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5E2"/>
    <dbReference type="STRING" id="6198.A0A074Z5E2"/>
    <dbReference type="GeneID" id="20326410"/>
    <dbReference type="KEGG" id="ovi:T265_12242"/>
    <dbReference type="CTD" id="20326410"/>
    <dbReference type="OrthoDB" id="6266258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="18945" checksum="F19745D709413E6F" modified="2014-10-01" version="1">MCNSQFWSASADFSLVCELAQYLPNCLFSIVCSGTPSAPTDLQVRKVTKSGVKLSWTAPTDNGGTPITGYVVRFWPPDNGASVEFPSPTTDVEAFVVADKLMGASSGQFDVAAINTKGVGQSSERADTTSLQEESAPPRLFQSSDAAYPRSEGVAGPESIEYQVGFSPTPNVTLTFVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5R2</accession>
    <name>A0A074Z5R2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597013">
        <property type="protein sequence ID" value="KER20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175374.1">
        <property type="nucleotide sequence ID" value="XM_009177110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5R2"/>
    <dbReference type="GeneID" id="20329394"/>
    <dbReference type="KEGG" id="ovi:T265_15229"/>
    <dbReference type="CTD" id="20329394"/>
    <dbReference type="OrthoDB" id="6253705at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="11158" checksum="B31BA2642D2947DB" modified="2014-10-01" version="1" fragment="single">MEADPWDMKVTPTQLKILADVSYKRSAIKEAQNYRKARMGDRWILTGNLKRNLEFPENWVSPGRETVPQYAVEWGLSTGEFLKEYRRGDAHNNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5V8</accession>
    <name>A0A074Z5V8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597009">
        <property type="protein sequence ID" value="KER20922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175325.1">
        <property type="nucleotide sequence ID" value="XM_009177061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5V8"/>
    <dbReference type="GeneID" id="20329373"/>
    <dbReference type="KEGG" id="ovi:T265_15208"/>
    <dbReference type="CTD" id="20329373"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="33052" checksum="F5B8DA8FB9C1D3F7" modified="2014-10-01" version="1" fragment="single">SLDGKISFNGPCNKHEVSNPICSHHYYPHRQHDIGRVSQHYNKTSPQFDAIGVSNWQTRTVTLLECKLRTKGLDDFGQFMQEDLRLLFLFKDEDDIVRIFHSDKAIWTPGFRLPFSDSLIISSITKLNRKEESGTLTDTALCTLLESSPYTLTRSEVRKYRKLIMFTKFKDITWWASVARGTDRSTESSASWKSRNTRILDEERVTAAAAILFTLSASFCLPKTISVDRPFLYSSYFDEEGVTAAAATVFIVDSCLPMHKTISVDHPFFFALVRDSTMPVFVGHVVAPNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z613</accession>
    <name>A0A074Z613_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597004">
        <property type="protein sequence ID" value="KER20992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175266.1">
        <property type="nucleotide sequence ID" value="XM_009177002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z613"/>
    <dbReference type="STRING" id="6198.A0A074Z613"/>
    <dbReference type="GeneID" id="20324753"/>
    <dbReference type="KEGG" id="ovi:T265_10585"/>
    <dbReference type="CTD" id="20324753"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703974" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="23025" checksum="3D779ED06B006884" modified="2014-10-01" version="1">MNLLSAATFLILVSEAVVVKKALIVIAPGFEEIEAVTVFRVLKSGTVQPTLVRLEHVTDPMVKGANGLSILTDGELNEDDANGYDLIVLPGGAKGTEEMKKSDRLKRILGSFVQKKKYIGAICLAPAVLKHFNLLLNSILTSYPSIENEMRQQYTYLEKSVVVDKQLITSRGPGTAMEFALKLVELLTGKQNSDTVANNFIFDKRDEISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6X9</accession>
    <name>A0A074Z6X9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_12065</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597399">
        <property type="protein sequence ID" value="KER18990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177262.1">
        <property type="nucleotide sequence ID" value="XM_009178998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6X9"/>
    <dbReference type="STRING" id="6198.A0A074Z6X9"/>
    <dbReference type="GeneID" id="20326233"/>
    <dbReference type="KEGG" id="ovi:T265_12065"/>
    <dbReference type="CTD" id="20326233"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF66">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="16">
        <location>
            <begin position="586"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="17">
        <location>
            <begin position="743"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER18990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="119991" checksum="92416EEF0374EC99" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z805</accession>
    <name>A0A074Z805_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_10062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596949">
        <property type="protein sequence ID" value="KER21672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174584.1">
        <property type="nucleotide sequence ID" value="XM_009176320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z805"/>
    <dbReference type="STRING" id="6198.A0A074Z805"/>
    <dbReference type="GeneID" id="20324230"/>
    <dbReference type="KEGG" id="ovi:T265_10062"/>
    <dbReference type="CTD" id="20324230"/>
    <dbReference type="OrthoDB" id="5977853at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15329">
        <property type="entry name" value="7tmA_5-HT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704963" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="88"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="530" mass="59345" checksum="BBD237B42F88087E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z830</accession>
    <name>A0A074Z830_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596946">
        <property type="protein sequence ID" value="KER21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174542.1">
        <property type="nucleotide sequence ID" value="XM_009176278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z830"/>
    <dbReference type="STRING" id="6198.A0A074Z830"/>
    <dbReference type="GeneID" id="20324198"/>
    <dbReference type="KEGG" id="ovi:T265_10030"/>
    <dbReference type="CTD" id="20324198"/>
    <dbReference type="OrthoDB" id="9858120at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="613" mass="69284" checksum="43A7A4FFF3901358" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8A0</accession>
    <name>A0A074Z8A0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174473.1">
        <property type="nucleotide sequence ID" value="XM_009176209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8A0"/>
    <dbReference type="STRING" id="6198.A0A074Z8A0"/>
    <dbReference type="GeneID" id="20324140"/>
    <dbReference type="KEGG" id="ovi:T265_09972"/>
    <dbReference type="CTD" id="20324140"/>
    <dbReference type="OrthoDB" id="6286708at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14183" checksum="2E563C0989D93961" modified="2014-10-01" version="1">MAGYPDLSALSLSENAGGCAGESSDDSSDEGEMYEEMLGCSYDEYGQLVSSAGSKTHQPEAPQPECPPIPQSVPQPCPQPSNAPRRMSCGGHMVRKKLTLSKDTSGKLGIKLKRMGSVSNPLFNKDKICDNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8A7</accession>
    <name>A0A074Z8A7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597200">
        <property type="protein sequence ID" value="KER19470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176784.1">
        <property type="nucleotide sequence ID" value="XM_009178520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8A7"/>
    <dbReference type="GeneID" id="20325937"/>
    <dbReference type="KEGG" id="ovi:T265_11769"/>
    <dbReference type="CTD" id="20325937"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="181" mass="20109" checksum="DC516F851EA13A3C" modified="2014-10-01" version="1">MTLSHVSIRTSGSANLGRMQCVCTIQVDTCGPDHLRVDKDCLIFVSGHKDGRESLKHSTKYKFKYEDQQTNRHLLEWPACIIHGQPIFDSNFAPQITGYRRVYVTELTQIDADQDSTSGNTTLHTYRIADAFSHCVLIAGVKGDSTKLISTFRIQDIGCPLASDSRTGCFDVLSDILTPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8U5</accession>
    <name>A0A074Z8U5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596845">
        <property type="protein sequence ID" value="KER23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172711.1">
        <property type="nucleotide sequence ID" value="XM_009174447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8U5"/>
    <dbReference type="GeneID" id="20322774"/>
    <dbReference type="KEGG" id="ovi:T265_08595"/>
    <dbReference type="CTD" id="20322774"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8209" checksum="A4561A5A05496B4E" modified="2014-10-01" version="1">MSKLNVEITDMTASTIWWYDSAVLDWLLGGFFYWNGCSSPKTSVSTTTAELVAYCPGQQSFQNSSRSPVFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z909</accession>
    <name>A0A074Z909_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597151">
        <property type="protein sequence ID" value="KER19710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176545.1">
        <property type="nucleotide sequence ID" value="XM_009178281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z909"/>
    <dbReference type="GeneID" id="20325758"/>
    <dbReference type="KEGG" id="ovi:T265_11590"/>
    <dbReference type="CTD" id="20325758"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8150" checksum="01D923FD3E2218F1" modified="2014-10-01" version="1">MPPDESTRAEIPPGSPSLDKGSGDADVGFEPRTFREGTPTPTTFQGVWFRRPEDDDSNHERPEMRLGLKPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAC1</accession>
    <name>A0A074ZAC1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Matrix-remodeling-associated protein 7 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597086">
        <property type="protein sequence ID" value="KER20150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176098.1">
        <property type="nucleotide sequence ID" value="XM_009177834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAC1"/>
    <dbReference type="GeneID" id="20325399"/>
    <dbReference type="KEGG" id="ovi:T265_11231"/>
    <dbReference type="CTD" id="20325399"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026622">
        <property type="entry name" value="Mxra7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057534">
        <property type="entry name" value="MXRA7_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845:SF2">
        <property type="entry name" value="MATRIX-REMODELING-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21845">
        <property type="entry name" value="TRANSMEMBRANE ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25473">
        <property type="entry name" value="MXRA7_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Matrix-remodeling-associated protein 7 helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="34435" checksum="DB2FFF072067CA3D" modified="2014-10-01" version="1">MAQWLEREFTDQKARGSNTTSASRLPPCRLGQPGSNTVLVLPSGGMATHYAVLTLDASDFLFCIVFVAFINVLVQKLIRLTTRHLSFRKIKDTGEGPVADTINSAGQPDASSFEHKASYVKELTKCPSRTAAVRHLHSHVLDSLSREEVEEERRVCKDQLTAIFQVMQSQPDRFGPMSEEDMEQQLSQFYEADPLPMKPRECEAQALLEKLTKVILKIQGLILDVVEHSMYLRSCIFFDISVIDEVNARISKAKIAFANSYHCGIKRASHLFSKDACNRLLYSCETWPLRAENLRHLHVSDQEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAF6</accession>
    <name>A0A074ZAF6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596823">
        <property type="protein sequence ID" value="KER24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172175.1">
        <property type="nucleotide sequence ID" value="XM_009173911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAF6"/>
    <dbReference type="STRING" id="6198.A0A074ZAF6"/>
    <dbReference type="GeneID" id="20322365"/>
    <dbReference type="KEGG" id="ovi:T265_08186"/>
    <dbReference type="CTD" id="20322365"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13536" checksum="6140B69344057018" modified="2014-10-01" version="1">MRGVQIALAGACSFTFLLLACALPQYAVWWPMFVLIFYILTPIPVFIARSQNEANTVRDICAFLTVILIFSAYALPILLARAPLGSPAIQWGACALTLTANTLMFAVIFWVLHLALKGDDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAU4</accession>
    <name>A0A074ZAU4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175894.1">
        <property type="nucleotide sequence ID" value="XM_009177630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAU4"/>
    <dbReference type="GeneID" id="20329497"/>
    <dbReference type="KEGG" id="ovi:T265_15332"/>
    <dbReference type="CTD" id="20329497"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="19915" checksum="7070C4B4138A6731" modified="2014-10-01" version="1" fragment="single">LGDLTVSQPSCLLRVQWQLGTRRVLQLNKHTLDAAEPSHFLCLEAFRHEKYMYRDLQVPKVTIATLSGLQHATSIVGVNLPTTGTSPHAGNNEQIHCVLICPDNWPSVTLSFWALCPLTLVVLQTVMQKSIILIIRRPKWLEREFTDWKVRGSNPTSASRLPLCRLRRPSHRASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBE6</accession>
    <name>A0A074ZBE6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_10932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597045">
        <property type="protein sequence ID" value="KER20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175712.1">
        <property type="nucleotide sequence ID" value="XM_009177448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBE6"/>
    <dbReference type="STRING" id="6198.A0A074ZBE6"/>
    <dbReference type="GeneID" id="20325100"/>
    <dbReference type="KEGG" id="ovi:T265_10932"/>
    <dbReference type="CTD" id="20325100"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="8">
        <location>
            <begin position="295"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="880" mass="101705" checksum="4BB593D95DF48962" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBF5</accession>
    <name>A0A074ZBF5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597043">
        <property type="protein sequence ID" value="KER20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175696.1">
        <property type="nucleotide sequence ID" value="XM_009177432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBF5"/>
    <dbReference type="STRING" id="6198.A0A074ZBF5"/>
    <dbReference type="GeneID" id="20329459"/>
    <dbReference type="KEGG" id="ovi:T265_15294"/>
    <dbReference type="CTD" id="20329459"/>
    <dbReference type="OrthoDB" id="6239193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="25316" checksum="83009D61C167F85E" modified="2014-10-01" version="1" fragment="single">EYDEDDSTQVSHSVTAALKGSVYTVNFVDSPGDAFEQNLEIKIQDCTDAFIVVYAIDDNASFAAARVIINTLSASFDPSQSPSVIRKGGSSQAVVPIPVLLVGNKTDLVRGRQVSSEDGRHFASLHDAKFIEVSASLNHMIAELFIQVVSLLGEAERKGRDPRLPNERRIKFPPSPGPSTSSGKTGVVSARNNNPIPTVTGSSTVASAFRIQPSTKHSLSKFLKKHFVRSSDDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBI5</accession>
    <name>A0A074ZBI5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171780.1">
        <property type="nucleotide sequence ID" value="XM_009173516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBI5"/>
    <dbReference type="GeneID" id="20328581"/>
    <dbReference type="KEGG" id="ovi:T265_14415"/>
    <dbReference type="CTD" id="20328581"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19279" checksum="2C00742FFD86D432" modified="2014-10-01" version="1" fragment="single">MRKHTTRLSPSVVSPLRTYPFKGMIIPPYHPHSSGLTIRLVHFSEQKVMKPRGSGKIQHFLALIPDDTKSTNEVIYDQCTHLHTDWFFMGNAPETQTNHSHATEARPMTTGFHLTSIREPGSRSKVRFNNCDAPCNFCSRLIGVEYLGSITFLKHYQEHAGNQKMTDASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCX9</accession>
    <name>A0A074ZCX9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosome subunit biogenesis protein NIP7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596847">
        <property type="protein sequence ID" value="KER23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172759.1">
        <property type="nucleotide sequence ID" value="XM_009174495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCX9"/>
    <dbReference type="STRING" id="6198.A0A074ZCX9"/>
    <dbReference type="GeneID" id="20328797"/>
    <dbReference type="KEGG" id="ovi:T265_14631"/>
    <dbReference type="CTD" id="20328797"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="27805" checksum="CDBE61FEA102A3FC" modified="2014-10-01" version="1" fragment="single">MSPPGVCWVNGKKPVCQALFKQGGKEIKRRETRFVVHGLEAGNHSRGGPLDTLNEVLFVPGITVNGVHPSMRPLKEKEHEQVVSKLCKYIKDVSVLLDRDDGSYTFMLHRDRVFYAKASLAKHAATITRKHLLSFGTCIGRFSKTGKFRIHVTALDFLAPYAKHRVWVKTPAEQQFLYGQHVLKSGLARISEDTPQYSGVVVMNMNDVPIGFGVAAKSTLQTKNTDPMTIVVFHQADLGEYIRSEDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDA1</accession>
    <name>A0A074ZDA1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596989">
        <property type="protein sequence ID" value="KER21160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175095.1">
        <property type="nucleotide sequence ID" value="XM_009176831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDA1"/>
    <dbReference type="STRING" id="6198.A0A074ZDA1"/>
    <dbReference type="GeneID" id="20324624"/>
    <dbReference type="KEGG" id="ovi:T265_10456"/>
    <dbReference type="CTD" id="20324624"/>
    <dbReference type="OrthoDB" id="6287109at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000054">
        <property type="entry name" value="Cyclic AMP-responsive element-binding protein 3-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="699" mass="75885" checksum="34259ACC0638CE44" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEI2</accession>
    <name>A0A074ZEI2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170671.1">
        <property type="nucleotide sequence ID" value="XM_009172407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEI2"/>
    <dbReference type="GeneID" id="20321169"/>
    <dbReference type="KEGG" id="ovi:T265_06990"/>
    <dbReference type="CTD" id="20321169"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="138" mass="15407" checksum="C0C93742DA486502" modified="2014-10-01" version="1">MPGCPSLDRRNREVTLTPFRYLTAMPPKGSTRARILPGCPSLDSGSRVPGVGFEPRAFRQSLEHFIPFWFADGGPNQVAWLEREFIDRKVRGSNSTSASRLPLSRLERPGSIREPMPHLCGVAVRHRKGATAGRFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEV3</accession>
    <name>A0A074ZEV3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170533.1">
        <property type="nucleotide sequence ID" value="XM_009172269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEV3"/>
    <dbReference type="STRING" id="6198.A0A074ZEV3"/>
    <dbReference type="GeneID" id="20321060"/>
    <dbReference type="KEGG" id="ovi:T265_06881"/>
    <dbReference type="CTD" id="20321060"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7759" checksum="4B086A4C442AFC95" modified="2014-10-01" version="1">MPTKSEVKAVLECLDSNKDGKISVEELKTFLDSANCILKREDVEAFIKTHDADKDGKLDLDELVACLSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFD6</accession>
    <name>A0A074ZFD6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">N-acetyllactosaminide 3-alpha-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596929">
        <property type="protein sequence ID" value="KER21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174309.1">
        <property type="nucleotide sequence ID" value="XM_009176045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFD6"/>
    <dbReference type="STRING" id="6198.A0A074ZFD6"/>
    <dbReference type="GeneID" id="20329141"/>
    <dbReference type="KEGG" id="ovi:T265_14975"/>
    <dbReference type="CTD" id="20329141"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046525">
        <property type="term" value="F:xylosylprotein 4-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF30">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="696"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110768" checksum="B46BCB390ECCCAB3" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFQ8</accession>
    <name>A0A074ZFQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174192.1">
        <property type="nucleotide sequence ID" value="XM_009175928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFQ8"/>
    <dbReference type="STRING" id="6198.A0A074ZFQ8"/>
    <dbReference type="GeneID" id="20323925"/>
    <dbReference type="KEGG" id="ovi:T265_09757"/>
    <dbReference type="CTD" id="20323925"/>
    <dbReference type="OrthoDB" id="10056300at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="416"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="75790" checksum="299C816587C72607" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGA8</accession>
    <name>A0A074ZGA8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171592.1">
        <property type="nucleotide sequence ID" value="XM_009173328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGA8"/>
    <dbReference type="GeneID" id="20328531"/>
    <dbReference type="KEGG" id="ovi:T265_14365"/>
    <dbReference type="CTD" id="20328531"/>
    <dbReference type="OrthoDB" id="6237019at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="166"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="467" mass="53200" checksum="A6B88E9689C7BFAE" modified="2014-10-01" version="1" fragment="single">ITLKKLSEKTFHSCCFWGATCNSDSSVKTVYVRTNQSKTDRWKSCRIQNRSSLFLLQLFGSPNESPMYPNACTTEPMKHRSTCSKSAFSAMQMDLSIMNPTIGVHEFRCRFPSSFLALITNYLGYLCFSPEDTKKIQNALIKESKALRTSAKSTGQQSRVNSSLDLPLTTQIRTASSKDHCADKELEHWYTVVHTLVLYLLEGKRYKQRFILRRPGNQSNMNELERKLFPPRVNPWSCSSNQTDEVLHRPAMATEIVTILEGYEISVLASVLARVLRHHGIGLIPRYLRNLFFQLVNNAKANEVYQRRAIRLLFQLVPTRLLLMVIRPVFELLAGIANEPTCEVDESSLAVLFSPILFSDQSTTTPASLANPVPARAVELLVRTALRDLQSYHSLDRTFQVPVLFQEDCVRNLTQHMILDNPQISCSLGHCVCKNQKLWTNRSTQTDSNMESCDQDCFLEVTRKMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGU6</accession>
    <name>A0A074ZGU6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173787.1">
        <property type="nucleotide sequence ID" value="XM_009175523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGU6"/>
    <dbReference type="STRING" id="6198.A0A074ZGU6"/>
    <dbReference type="GeneID" id="20329012"/>
    <dbReference type="KEGG" id="ovi:T265_14846"/>
    <dbReference type="CTD" id="20329012"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11272" checksum="804F9FAD0428F0D2" modified="2014-10-01" version="1" fragment="single">CLSALLPTFYSPTVLVYPDGRVCISILHAPGDDPMGYESSVERWSPVQSVEKILLSVVSMLAEPNDESAANVDAAKTWREDKRRFNKLALRSVRISLGLPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH66</accession>
    <name>A0A074ZH66_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596892">
        <property type="protein sequence ID" value="KER22565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173702.1">
        <property type="nucleotide sequence ID" value="XM_009175438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH66"/>
    <dbReference type="GeneID" id="20323563"/>
    <dbReference type="KEGG" id="ovi:T265_09394"/>
    <dbReference type="CTD" id="20323563"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6542" checksum="A3BFF74E657C5507" modified="2014-10-01" version="1">MDLISLGTSSRTASQKLHGVKWLDEASDMMKQSMGVLPSDDGQTNSNIDSVLQMGTKKGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHT2</accession>
    <name>A0A074ZHT2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170914.1">
        <property type="nucleotide sequence ID" value="XM_009172650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHT2"/>
    <dbReference type="GeneID" id="20321373"/>
    <dbReference type="KEGG" id="ovi:T265_07194"/>
    <dbReference type="CTD" id="20321373"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12311" checksum="A39DA664191A5933" modified="2014-10-01" version="1">MRPNVIDEKQHCVDKSLVLSHDSENPQTRTYIRKLSQLLSKTWNGDRKQPHHVTPRLHCMRYNSDVLVAQNLVQLRSRTRVEPNSTICAHAQTVRNEEDKVSNAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI78</accession>
    <name>A0A074ZI78_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170767.1">
        <property type="nucleotide sequence ID" value="XM_009172503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI78"/>
    <dbReference type="GeneID" id="20321253"/>
    <dbReference type="KEGG" id="ovi:T265_07074"/>
    <dbReference type="CTD" id="20321253"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="282" mass="32319" checksum="632629156C2D1B59" modified="2014-10-01" version="1">MRPEESRGKLYFGDLCLGCYYEPITYFKAEITVGEEVVFQGENRVLVDSGTSFTFGPKVEVVAINKRLTQEAAHHGVYIVDCRRILNFPLVKFSNGDSTLTLSPREYIFRVNENNSDACDKNDALCVWESNRIKVIETAKSCHLSIKSFCCNTISVPSCHASRRKHKGWDTVRLPKPRWSKSRGSGRFRTTGLQLNLRVRIVPASNQLIGTVSFVRIVIEFRRVPDDQQLRGQLCFSSFAYRVGITESFWRFGAALNRMFYTVYDKEEERVGFARSKIQQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIF6</accession>
    <name>A0A074ZIF6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173156.1">
        <property type="nucleotide sequence ID" value="XM_009174892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIF6"/>
    <dbReference type="STRING" id="6198.A0A074ZIF6"/>
    <dbReference type="GeneID" id="20323128"/>
    <dbReference type="KEGG" id="ovi:T265_08949"/>
    <dbReference type="CTD" id="20323128"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71126" checksum="22CE08B98D3AD997" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJH8</accession>
    <name>A0A074ZJH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170293.1">
        <property type="nucleotide sequence ID" value="XM_009172029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJH8"/>
    <dbReference type="STRING" id="6198.A0A074ZJH8"/>
    <dbReference type="GeneID" id="20320874"/>
    <dbReference type="KEGG" id="ovi:T265_06695"/>
    <dbReference type="CTD" id="20320874"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="228" mass="26359" checksum="16C84ED3F28DBF93" modified="2014-10-01" version="1">MNIRVRKRTIYVARHGETEFNLSGRIGGDSSLSPAGKKFAIQLGAFMKQENVPDLKVWTSYLNRTIQTAEHIPVTTIEHWKALDELDAGVCDGMTYAEIQEKYPYDFAMRDADKYHFRYPMGESYHDLVGRLEPVMMELERQSSVLVICHQAVARCLLAYFEDRPQEELPYIRVPLHTVFKLTPIAYRCIVERIHLQVPAVDTHRPKPANIEPNRRSFEALQTVPAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKF5</accession>
    <name>A0A074ZKF5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168757.1">
        <property type="nucleotide sequence ID" value="XM_009170493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKF5"/>
    <dbReference type="GeneID" id="20319664"/>
    <dbReference type="KEGG" id="ovi:T265_05482"/>
    <dbReference type="CTD" id="20319664"/>
    <dbReference type="OrthoDB" id="6246848at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13839" checksum="28E3E6C6D70F3D0E" modified="2014-10-01" version="1">MRQIRQTDGPRKFRIADVVYARNFQGPEKWSSGTVLGKKGNVVYEVDVGQDVSTSYDQTTCKLNTGKKQKVSSGTSCLDDEHVRRLELSQNMTVPHSLQLRPNRKRKRPNWLQVPIRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKL3</accession>
    <name>A0A074ZKL3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169951.1">
        <property type="nucleotide sequence ID" value="XM_009171687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKL3"/>
    <dbReference type="GeneID" id="20320608"/>
    <dbReference type="KEGG" id="ovi:T265_06429"/>
    <dbReference type="CTD" id="20320608"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="7113" checksum="FBA481E45E3E93AD" modified="2014-10-01" version="1">MKPYRPTAGLGLYSSTTGDEVLEVEYYIEYTEPTYRYVQPARSMKAVYLVAPRRNRVLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLN2</accession>
    <name>A0A074ZLN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_08011</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596816">
        <property type="protein sequence ID" value="KER24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171962.1">
        <property type="nucleotide sequence ID" value="XM_009173698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLN2"/>
    <dbReference type="STRING" id="6198.A0A074ZLN2"/>
    <dbReference type="GeneID" id="20322190"/>
    <dbReference type="KEGG" id="ovi:T265_08011"/>
    <dbReference type="CTD" id="20322190"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="32151" checksum="D9435ABAF6DA8049" modified="2014-10-01" version="1">MYQMLQGLLFCHGRRVIHRDLKPQNILVDVGRKIVKLADFGLARAFGIPVRVLTHEVVTLWYRAPEILLGAQRYSCAVDIWSMGCIFSEVATKEALFRGDSEIDQLFRIFRLLGTPSEDVWPGVTNLPDYKKKGFPLWRESKLTTNENITKAFNDLGLSLLQAMLIYEPSRRITARDALLHPYFADLDKSTVPATGEEYIGLPLDQLPHEVAAMFLADAGEAYRTESDRENAGRQLGVLPSTVELGADSLPTSKFLSTTQKGQHTSMDTTSQPTVPLADSHEVNMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNB1</accession>
    <name>A0A074ZNB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167342.1">
        <property type="nucleotide sequence ID" value="XM_009169078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNB1"/>
    <dbReference type="GeneID" id="20318539"/>
    <dbReference type="KEGG" id="ovi:T265_04357"/>
    <dbReference type="CTD" id="20318539"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="47" mass="5357" checksum="5FDB78DABF41C5AF" modified="2014-10-01" version="1" fragment="single">ATRRKHDGWVTARGKPSTSLVPSCRAIRREHDGWDTARFPKPGQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP05</accession>
    <name>A0A074ZP05_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171173.1">
        <property type="nucleotide sequence ID" value="XM_009172909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP05"/>
    <dbReference type="STRING" id="6198.A0A074ZP05"/>
    <dbReference type="GeneID" id="20321578"/>
    <dbReference type="KEGG" id="ovi:T265_07399"/>
    <dbReference type="CTD" id="20321578"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="302"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="653" mass="74486" checksum="52E3C10F8EEA79F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP69</accession>
    <name>A0A074ZP69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171118.1">
        <property type="nucleotide sequence ID" value="XM_009172854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP69"/>
    <dbReference type="GeneID" id="20321534"/>
    <dbReference type="KEGG" id="ovi:T265_07355"/>
    <dbReference type="CTD" id="20321534"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="34113" checksum="DBF8E011F5EDC361" modified="2014-10-01" version="1">MKTRKVEKAFRVRFSTNGGIVTGDFHVIVSFHYYNWYNIRVSVSYHFGANHPEELPILLLGKITLWQLPSIIHPVRLCSVPPVWIFTREDNHNRIWPKLIRFHVIVSFHYYNWYNIRVSVSYHFGANHPEELPILLLGKITLWQLPSIIHPVRLCSVPPVWIFTREDNHNRIWPKFRNPVCPLTETTWQILIGPLAYVADNVRDKFKGYPSEPQINSVQLINISSGLISPGCCSFQTRRLFVKVKDSIHMAKLNLSSKGVSIFHRVLFFVNGENPKFGQVHPTKDGFRNTSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPE5</accession>
    <name>A0A074ZPE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166973.1">
        <property type="nucleotide sequence ID" value="XM_009168709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPE5"/>
    <dbReference type="GeneID" id="20327568"/>
    <dbReference type="KEGG" id="ovi:T265_13401"/>
    <dbReference type="CTD" id="20327568"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15245" checksum="8FCDDBF30D672ABA" modified="2014-10-01" version="1" fragment="single">MRSIIHLVQYASGPSALPNPLLGCAAAIRLTLTSQSFFHFMLGGIPHGSRFDRSWSGAATTEKPIPRKADQQFGTLAGLVSSQELISRKSGPYSHAVQLSLTSFLGANIPCAPLARLKHEAAWYSTFSGLETSKPRDSAGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQG8</accession>
    <name>A0A074ZQG8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166898.1">
        <property type="nucleotide sequence ID" value="XM_009168634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQG8"/>
    <dbReference type="GeneID" id="20318202"/>
    <dbReference type="KEGG" id="ovi:T265_04016"/>
    <dbReference type="CTD" id="20318202"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="27630" checksum="FC7C7EBF3E9FDCE6" modified="2014-10-01" version="1">MRSDLMMEHLEETLEDDKGHPGRRKTGLWRRRGYSQLGRRKTSWYYFPTVFSSRRSAEASFLMVLWSRVKFITDVQLALSLPHMDRDVSEAVIFTHRRMLQKVRIIPEFKKRLKPNLNVHHCSCSQRKPEQFTTGIAYVMASRIDYRGPRCSAEVADGRDRTEQTEDLRTFPVVTLGHAMFRYEANTKIISTTSGKLSEKHLKNCGDDCFTSDLQQPPHNRSGHLYTRYSIVSLQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQV3</accession>
    <name>A0A074ZQV3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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                <person name="Nagarajan N."/>
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                <person name="Hall R.S."/>
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                <person name="Wongkham S."/>
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                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Tan P."/>
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</entry>
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                <person name="Nagarajan N."/>
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                <person name="Hall R.S."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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        </source>
    </evidence>
    <sequence length="319" mass="33661" checksum="D919FCF8C60CF315" modified="2014-10-01" version="1">MQYIASTMPGSEYSTSALIAKPEPSSQTSPSSPAQARNATKHTEAHETVDNLSMGTRKESQPPIPTDIAKGSSALHSTEKPAPTLTAKPESSLQTLPSFQSHASTATKNNKTHETVNISTVTTLQESLPPTDIPHESSALPSTENATSTLTVTPMSSSKTSADLEVYSTSQTNSTYTDESEKNSTWSTPEEQQSSSSIDMQIEILTMSCTKISTSAPTAKPSTSLETTPSSQPHASIATKNTETDETVDNLTETTIQETQSPISTDIPNGSSSLHSTETAASALTVTPISSSQTSTSIEVYSTSASYTTNTDESENHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTX0</accession>
    <name>A0A074ZTX0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165319.1">
        <property type="nucleotide sequence ID" value="XM_009167055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTX0"/>
    <dbReference type="GeneID" id="20316928"/>
    <dbReference type="KEGG" id="ovi:T265_02740"/>
    <dbReference type="CTD" id="20316928"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="17094" checksum="DA58B785733595F1" modified="2014-10-01" version="1">MRSNAARLDSAEESSAACVRYRVYLTGCFHKGNRCQEDKVKLFRFNVVTTMRVHLNSLKHLKNRITRLDKSLIHDTSKVAPPVPTEKPLVLDWESSLREPVKNPVSSPVTAKLYTACVAGAKNSADRHFFAEGRTEANRPSIRRLTRRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU56</accession>
    <name>A0A074ZU56_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165625.1">
        <property type="nucleotide sequence ID" value="XM_009167361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU56"/>
    <dbReference type="GeneID" id="20317170"/>
    <dbReference type="KEGG" id="ovi:T265_02982"/>
    <dbReference type="CTD" id="20317170"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17644" checksum="3BF736084753E9EA" modified="2014-10-01" version="1">MKTKDAKPGRVWEISELLAEEDHLSQQVKEYFSPTGFHHIFISAKSSMIAQTLYIGRRLDRLLHRYHSMSQTGLAKNPGELWLHGIGPRAIERCVDLALHLENRLYPGHISTSVRTSTCATIRQAIAAVEPGSVSITEQEQPKSAIHIQLRLIPTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUG4</accession>
    <name>A0A074ZUG4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166822.1">
        <property type="nucleotide sequence ID" value="XM_009168558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUG4"/>
    <dbReference type="STRING" id="6198.A0A074ZUG4"/>
    <dbReference type="GeneID" id="20327533"/>
    <dbReference type="KEGG" id="ovi:T265_13366"/>
    <dbReference type="CTD" id="20327533"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="449" mass="50778" checksum="ACA0D997BE1F7A4F" modified="2014-10-01" version="1" fragment="single">MFPTQISQGFTQSDEMKVLSDEASNKVPFICVARKRNPSRSQFGSSSSPSVRSHLIRNECDGVQSDGPALNTSTNKELNLTKDASDALVYQKKCQNSKSKSVTRVNVEAAPKCVLQLQRSNQPSIVTKSEMDPFVPEASEMSQHTSATRDLPVSNLHLPLQPEQRQGFSNAHKRSSLRYIDSSLTGNPIKIKNVQFEPHHNEDFSSSWPRQQISDVKELYGKLAQKDEEIRQRDIRIHELQEIILEHNQLLSRLTGVRWNEERPFLRNAVINLEQHSRTSPAGLVTSDTNSSGYGQGTFVEKTSVFPQSSVHHNFLEELPMTAWPVHRGTAASAMQTYTAAEKRGNSTRNTKPFHPFKLPKRRKRYAISGESSQYLLTPSSQLAQLPKFTKSDRTKQLITQAILENDFMKHLDSWQISEMIDSMCPLRCARLSWIIQEGEIGSVVYVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV22</accession>
    <name>A0A074ZV22_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169078.1">
        <property type="nucleotide sequence ID" value="XM_009170814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV22"/>
    <dbReference type="GeneID" id="20319923"/>
    <dbReference type="KEGG" id="ovi:T265_05741"/>
    <dbReference type="CTD" id="20319923"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="17188" checksum="358650E7430C155F" modified="2014-10-01" version="1">MGKEVSCAHPHTDTHSNTQVSDRMASAASNQAVVGHWISLPCIGEAPLTASHVEPDPAVTITSRGAFRSAGAVLQPLGFGKRGQIVGVKRETGESPGECLKHTVADGAPSAASNMLAGWMWTERMWNAAERAQESSGTKYGEATARSWGKAGGVAPSTLVSSEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV31</accession>
    <name>A0A074ZV31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169020.1">
        <property type="nucleotide sequence ID" value="XM_009170756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV31"/>
    <dbReference type="STRING" id="6198.A0A074ZV31"/>
    <dbReference type="GeneID" id="20319869"/>
    <dbReference type="KEGG" id="ovi:T265_05687"/>
    <dbReference type="CTD" id="20319869"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="G_SEPTIN_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="74"/>
            <end position="363"/>
        </location>
    </feature>
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            <end position="618"/>
        </location>
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            <end position="427"/>
        </location>
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            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="693" mass="78071" checksum="99EBD40954DF6F9A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVD8</accession>
    <name>A0A074ZVD8_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31096.1"/>
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        <property type="nucleotide sequence ID" value="XM_009166880.1"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="290"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="722" mass="82037" checksum="017BE9FFF79F21F9" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVQ3</accession>
    <name>A0A074ZVQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_11918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597274">
        <property type="protein sequence ID" value="KER19244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVQ3"/>
    <dbReference type="STRING" id="6198.A0A074ZVQ3"/>
    <dbReference type="GeneID" id="20326086"/>
    <dbReference type="KEGG" id="ovi:T265_11918"/>
    <dbReference type="CTD" id="20326086"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="198"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="691" mass="79286" checksum="55E05C96697CB01C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVX4</accession>
    <name>A0A074ZVX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164695.1">
        <property type="nucleotide sequence ID" value="XM_009166431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVX4"/>
    <dbReference type="GeneID" id="20316431"/>
    <dbReference type="KEGG" id="ovi:T265_02243"/>
    <dbReference type="CTD" id="20316431"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="22756" checksum="B9CEB16328F978D4" modified="2014-10-01" version="1">MRIEGWANFDLESLPVISSMARRQLFSLIRSIYALVFSGPTMRIASPGIKTDGNKRRTSESLRGRANPDRYAHVRLPVTALGVSRGLVETAGSLETACSDFGLLSTVNAEYASSCKREMGVRRTGGKAPSGRKGRAFAERRISRSLAEGNETRARTEPGVLVALLSPGANVAIVTSEAERPGAPRKRTISALLVSGGKSATSRHPSAWCGGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWS1</accession>
    <name>A0A074ZWS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164393.1">
        <property type="nucleotide sequence ID" value="XM_009166129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWS1"/>
    <dbReference type="STRING" id="6198.A0A074ZWS1"/>
    <dbReference type="GeneID" id="20316179"/>
    <dbReference type="KEGG" id="ovi:T265_01991"/>
    <dbReference type="CTD" id="20316179"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="16126" checksum="2397381633BA3C8C" modified="2014-10-01" version="1">MPPNVAYRDNDSVVVFGYGSLIWKPNFPYSQRIVGYVRGYKRRFYQGNVFHRGTPERNHCLRKRPLFSVSSSEWHKQSVGHHLTRQGSVRSITKNSGTIGTTDPLGCCLHDPCCAWFGKLCGLTNTRYLCRSCCQFLSIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX18</accession>
    <name>A0A074ZX18_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165801.1">
        <property type="nucleotide sequence ID" value="XM_009167537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX18"/>
    <dbReference type="STRING" id="6198.A0A074ZX18"/>
    <dbReference type="GeneID" id="20327335"/>
    <dbReference type="KEGG" id="ovi:T265_13167"/>
    <dbReference type="CTD" id="20327335"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="634" mass="69915" checksum="459703BDD71B0417" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX57</accession>
    <name>A0A074ZX57_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-binding protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597143">
        <property type="protein sequence ID" value="KER19759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176499.1">
        <property type="nucleotide sequence ID" value="XM_009178235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX57"/>
    <dbReference type="STRING" id="6198.A0A074ZX57"/>
    <dbReference type="GeneID" id="20325721"/>
    <dbReference type="KEGG" id="ovi:T265_11553"/>
    <dbReference type="CTD" id="20325721"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51809" checksum="8DDA42F072B876BE" modified="2014-10-01" version="1">MEEHSFFEQLPPSKRHEVEVRFNIAFVISQQSQLDILNQTAPQINQLENNLLAARATYQNTLTEHSSRLNAIGKRLGKCVQRARPYYDAKAKQAELTREIQRATERYNRANDLLTASCQALSKLENATPTGTRQVGDVVSLEALNQCIFKVNEAKREALEAKEQHERLLATYNDTEKSIHNMERRLKMDIKKAQLYFSTKQRFDERMQEAKLRVESCADRVNLCKSLYAEAMLKLEQISESLHDTRRRKTLDLDTNSRFLHDDGSPSPLVRGQGVGADSLECINEPDCRAVHSPVCIHAGSAAPSRISSEFSSAPDLSSPNLVSLHSETVPVEIVTGLIQNVHEAESELGAFRLAVTSSNPTSEMSVASSSTGATSLSSSVSFSSQSDVNELPQRLSAPRFHTTYNHNVDNVAPQFVDLEMDALSPNFSESKINARSLSYVQCAPLKSNYSEKSLSCDLSGLTLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXJ6</accession>
    <name>A0A074ZXJ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597116">
        <property type="protein sequence ID" value="KER19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176311.1">
        <property type="nucleotide sequence ID" value="XM_009178047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXJ6"/>
    <dbReference type="STRING" id="6198.A0A074ZXJ6"/>
    <dbReference type="GeneID" id="20325570"/>
    <dbReference type="KEGG" id="ovi:T265_11402"/>
    <dbReference type="CTD" id="20325570"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27856" checksum="98674DB29552AEF4" modified="2014-10-01" version="1">MVYHRQLSDRYTLSVPSCHATRRRHEGWDTARLPKPRQGKSRGTQIVIDVFIPKPFRSFAFVTFDDPDVAASLLGKDLTIQGHKVTIGSAVPKLPSHVRQNPAFENAGGNLRSPYPGSPMAHGPLWNSPWARWPKWLEREFTDRKVRGSNPTSVTRLPLSRLGQPGSIPALVLPSCGMAARHRKGATAERFLSFFMGPSHQNPGVRWLSGKSANLLAGRYVVQTRSPPLDFPCRGLDNLAVSYPSSFLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXQ9</accession>
    <name>A0A074ZXQ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597109">
        <property type="protein sequence ID" value="KER19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176265.1">
        <property type="nucleotide sequence ID" value="XM_009178001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXQ9"/>
    <dbReference type="GeneID" id="20325534"/>
    <dbReference type="KEGG" id="ovi:T265_11366"/>
    <dbReference type="CTD" id="20325534"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="53" mass="5953" checksum="6F0FCBADCF2AFC25" modified="2014-10-01" version="1">MQLRFAILKFSQPVTLCTFQNQNAAANCLTTKVLFSRLVIRLFIPITSTAHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYQ4</accession>
    <name>A0A074ZYQ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_02569</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165112.1">
        <property type="nucleotide sequence ID" value="XM_009166848.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYQ4"/>
    <dbReference type="GeneID" id="20316757"/>
    <dbReference type="KEGG" id="ovi:T265_02569"/>
    <dbReference type="CTD" id="20316757"/>
    <dbReference type="OrthoDB" id="3359639at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1071"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="886"/>
            <end position="909"/>
        </location>
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        <location>
            <begin position="2095"/>
            <end position="2288"/>
        </location>
    </feature>
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        <location>
            <begin position="1744"/>
            <end position="2026"/>
        </location>
    </feature>
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            <begin position="886"/>
            <end position="902"/>
        </location>
    </feature>
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        <location>
            <begin position="2096"/>
            <end position="2110"/>
        </location>
    </feature>
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            <begin position="2144"/>
            <end position="2157"/>
        </location>
    </feature>
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        <location>
            <begin position="2171"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="2258"/>
            <end position="2272"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2331" mass="264153" checksum="49E45C08EC7BF9E9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYW3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">T265_01684</name>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="GeneID" id="20315872"/>
    <dbReference type="KEGG" id="ovi:T265_01684"/>
    <dbReference type="CTD" id="20315872"/>
    <dbReference type="OrthoDB" id="6222656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853:SF1">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Guanylate kinase/L-type calcium channel beta subunit domain-containing protein</fullName>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Digenea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
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                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20399.1"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000584">
        <property type="entry name" value="VDCC_L_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11824">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01626">
        <property type="entry name" value="LCACHANNELB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase/L-type calcium channel beta subunit" evidence="3">
        <location>
            <begin position="294"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="998" mass="108264" checksum="CA36033192C9A4E5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYZ5</accession>
    <name>A0A074ZYZ5_OPIVI</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01716</name>
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    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Digenea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164046.1">
        <property type="nucleotide sequence ID" value="XM_009165782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYZ5"/>
    <dbReference type="STRING" id="6198.A0A074ZYZ5"/>
    <dbReference type="GeneID" id="20315904"/>
    <dbReference type="KEGG" id="ovi:T265_01716"/>
    <dbReference type="CTD" id="20315904"/>
    <dbReference type="OrthoDB" id="6614841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34601" checksum="0E1B9101AAA5911D" modified="2014-10-01" version="1">MFDTGGFTRWLPSSASQDEKFEGKTKYDINSPTRTSLNKAYETAYGGDYHEGNVVADELVIQGHCVPEFIFVEMARIAGSVDKREGYDGVFGMKRPKKTHMAWEFFNTTLIDYLVSADIVQDGRFTFRFCGQPGVRGVSWFERGDLVFGGIMADHHHMPIVYLPVFESKLWTIYADSISYGNIILCAPCRIAVDTGSPVTYAPTRSSQILLKNSVIEEYANGILHVEPRNLPYVREITVTLRSQIFTLPPAELLRYKSEVHVYGIQLEPDVRKKEWIFGISFLRRFLTIFDQQNNQMGFASVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZA9</accession>
    <name>A0A074ZZA9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_10945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597048">
        <property type="protein sequence ID" value="KER20514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175727.1">
        <property type="nucleotide sequence ID" value="XM_009177463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZA9"/>
    <dbReference type="STRING" id="6198.A0A074ZZA9"/>
    <dbReference type="GeneID" id="20325113"/>
    <dbReference type="KEGG" id="ovi:T265_10945"/>
    <dbReference type="CTD" id="20325113"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="54706" checksum="D7B9EE49AC0C6B21" modified="2014-10-01" version="1">MDGISGEESCSTQNSKAEEVEKSANKKKKKPKEFDMPSDVTEENMEVSEDISPEAYIPGRSRPLMEDEQLVMDKSSYRLFYDLQLEYASLSFDILLDNLGSGREVEVNGSEISASLLAGTQAAPGMGDALVVLRMSNMKPFQRKVHPEDDSADKSDDSDESSSSDEDLDSQPELEAAKIRHRGTVNRVRAFQYGGRYLAASWSEEAKVFIWDLTRPLTAVNDSAVMSEYVRFNETPVPLFTNKRHKSEGFALDWSPHPLASGHLASGDCDGVIYHWVPQPTGWSLGKKAYTGHTGSVEDIQWSITEPTVFISVSSDRSIRVWDTRSPPNAGSMLTVPDAHTADVNVLSWNRLQSTSLLTGGDDGALRVWDLRLVHKRYAPGGKPNKIPAYTHVYDYHTKPITSVEWHPNDAGVFVATSEDDQVTIWDTTLEQADQPMDDALAKGDETANLPVQLLFIHCGQTEIKEAHWHPQIPGLLVVTSIDGFNVFRTCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZR6</accession>
    <name>A0A074ZZR6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164744.1">
        <property type="nucleotide sequence ID" value="XM_009166480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZR6"/>
    <dbReference type="GeneID" id="20316464"/>
    <dbReference type="KEGG" id="ovi:T265_02276"/>
    <dbReference type="CTD" id="20316464"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9619" checksum="AA9D8BBAD801311C" modified="2014-10-01" version="1">MCLLLTLKEISLPFSLHCDMLRGQVRLRQIFGNGLSTRPSFLPLGRSAHASRYAARLPALLRPIRLASTRLAKNSGGTKASSDWSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZT9</accession>
    <name>A0A074ZZT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163277.1">
        <property type="nucleotide sequence ID" value="XM_009165013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZT9"/>
    <dbReference type="GeneID" id="20315258"/>
    <dbReference type="KEGG" id="ovi:T265_01070"/>
    <dbReference type="CTD" id="20315258"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="11612" checksum="BD875718606F611D" modified="2014-10-01" version="1">MKLDSLVVVYTRKQHTTVHCQDTAAWAIIKRSTILSAGSTIEVNSFDGCLVLSLPANDSQGLDVLDTMVRVTTGLNLPTVEMAKATKSTDRWLCQFSVDNNGGKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZZ8</accession>
    <name>A0A074ZZZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597027">
        <property type="protein sequence ID" value="KER20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175531.1">
        <property type="nucleotide sequence ID" value="XM_009177267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZZZ8"/>
    <dbReference type="GeneID" id="20324963"/>
    <dbReference type="KEGG" id="ovi:T265_10795"/>
    <dbReference type="CTD" id="20324963"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF148">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704412" description="FZ domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="12">
        <location>
            <begin position="55"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="535" mass="61052" checksum="EC9AB48D15AA7610" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Z6</accession>
    <name>A0A075A0Z6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167097.1">
        <property type="nucleotide sequence ID" value="XM_009168833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Z6"/>
    <dbReference type="GeneID" id="20318349"/>
    <dbReference type="KEGG" id="ovi:T265_04163"/>
    <dbReference type="CTD" id="20318349"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17023" checksum="911A496DA38CC57A" modified="2014-10-01" version="1">MGRGLETAASPDFTVVINLRVSTELRKDSTIGTLRYPEEERLRSSKIKGSKTLLLAHLEACSKRWNNPVSAIKNILATAAPIVDVCFCISHGFVKIPFEGIKDAHTASIVLIGEQIACNGDAASRWNVLLHPVSDPSSHHQTNLLPTLSGCPNNVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2I1</accession>
    <name>A0A075A2I1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162372.1">
        <property type="nucleotide sequence ID" value="XM_009164108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2I1"/>
    <dbReference type="GeneID" id="20314551"/>
    <dbReference type="KEGG" id="ovi:T265_00363"/>
    <dbReference type="CTD" id="20314551"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11211" checksum="5212296087EC9DDF" modified="2014-10-01" version="1">MRFSSSKRFTATLSEKTDMCQSEAMQRPLESRSKNSGVRGPVDFFMATSTSSQSSQHVNMSMNSFRVFVPSLHVYDPPRPLECLIVALTGIDMAESQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2L7</accession>
    <name>A0A075A2L7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162564.1">
        <property type="nucleotide sequence ID" value="XM_009164300.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A2L7"/>
    <dbReference type="GeneID" id="20314684"/>
    <dbReference type="KEGG" id="ovi:T265_00496"/>
    <dbReference type="CTD" id="20314684"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="386"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1290" mass="144653" checksum="F855A5835AACCCE1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Z8</accession>
    <name>A0A075A2Z8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596943">
        <property type="protein sequence ID" value="KER21759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174497.1">
        <property type="nucleotide sequence ID" value="XM_009176233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Z8"/>
    <dbReference type="GeneID" id="20324164"/>
    <dbReference type="KEGG" id="ovi:T265_09996"/>
    <dbReference type="CTD" id="20324164"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9164" checksum="49E3379A4AFC4450" modified="2014-10-01" version="1">MSHLCRDSSDEREQVGHATGTSFSISESPLYAAGEFMLKSAKASVALFHGLILIKYSDRISAKLEYQEAKLLGEAALLNENETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3I4</accession>
    <name>A0A075A3I4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166114.1">
        <property type="nucleotide sequence ID" value="XM_009167850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3I4"/>
    <dbReference type="GeneID" id="20317568"/>
    <dbReference type="KEGG" id="ovi:T265_03381"/>
    <dbReference type="CTD" id="20317568"/>
    <dbReference type="OrthoDB" id="6274103at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="8156" checksum="E081D4B5764BE238" modified="2014-10-01" version="1">MVHSTKTDYRDGGNCQASQCALNPHCRSVYFHKQDRRCILMLYADALLPAKLVRSRNRWTRFGKVANEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A432</accession>
    <name>A0A075A432_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165908.1">
        <property type="nucleotide sequence ID" value="XM_009167644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A432"/>
    <dbReference type="STRING" id="6198.A0A075A432"/>
    <dbReference type="GeneID" id="20327346"/>
    <dbReference type="KEGG" id="ovi:T265_13178"/>
    <dbReference type="CTD" id="20327346"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="382"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="698" mass="77291" checksum="DFB78C38E555278B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A435</accession>
    <name>A0A075A435_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163204.1">
        <property type="nucleotide sequence ID" value="XM_009164940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A435"/>
    <dbReference type="GeneID" id="20326845"/>
    <dbReference type="KEGG" id="ovi:T265_12677"/>
    <dbReference type="CTD" id="20326845"/>
    <dbReference type="OrthoDB" id="6238496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="57"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="32419" checksum="AA7B94BA6C8CFA51" modified="2014-10-01" version="1" fragment="single">TNPVKLCYESVPSRTTAGLFWHSKTQWNTTSHMLLSSYREMSRENPKSDQHLLPTCPIKISVPHAVLRNHRGQGTYYVYTIQIKIVPPSQFTAADQSDTISDCKWSVEHRYTTLAELHEDLLGYNDDLTRNRKRISGSDHEERYLAHPCLPRPFPCLEDIPFPRRRLLPTIHPPSVYPWLNCVRAISDKRDKPVLPGQSKRVDQRRNALETYLNELVTLIWTTVQTTEVANIVHSIVLRDLPQESCGVDQWKCLMNAQEIQCWLTTLLPIFSKSKFDKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A564</accession>
    <name>A0A075A564_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165576.1">
        <property type="nucleotide sequence ID" value="XM_009167312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A564"/>
    <dbReference type="GeneID" id="20317136"/>
    <dbReference type="KEGG" id="ovi:T265_02948"/>
    <dbReference type="CTD" id="20317136"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="13940" checksum="69E3D0FB5927E8E9" modified="2014-10-01" version="1">MTTWYRMDSLVGHHVTPQSTCPKFPSSSVHLAVDQEYNKMSTGKEQIIGLCPGIREKRPVSSEAPESFSRSISGSTLPADKLRPVTSVWISARVKRRLLEFRAASCDKNGEVQTVVSRKSAKYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A689</accession>
    <name>A0A075A689_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_12511</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162411.1">
        <property type="nucleotide sequence ID" value="XM_009164147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A689"/>
    <dbReference type="STRING" id="6198.A0A075A689"/>
    <dbReference type="GeneID" id="20326679"/>
    <dbReference type="KEGG" id="ovi:T265_12511"/>
    <dbReference type="CTD" id="20326679"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="287"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="929" mass="105883" checksum="2F97B3A63F5E81DC" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A703</accession>
    <name>A0A075A703_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173065.1">
        <property type="nucleotide sequence ID" value="XM_009174801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A703"/>
    <dbReference type="GeneID" id="20323058"/>
    <dbReference type="KEGG" id="ovi:T265_08879"/>
    <dbReference type="CTD" id="20323058"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="180" mass="20487" checksum="35D8B9AE6EF96600" modified="2014-10-01" version="1">MSIEFDQLRELLQQQQKQFEEAQLKLIESLTQKLHIQTAAVSTDFKVDPLVFTCIFYFCYLRRVKLEIAAWYLSPSFSRTLGTQNATNANYTTKHKQIKQVYALALISKLNLIVEGVSDENGHIVQKEDTDGLNAHYYSLESGLINRKAIGNGALSHVHIAVANQKLAFRHQESQSHSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABR7</accession>
    <name>A0A075ABR7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171154.1">
        <property type="nucleotide sequence ID" value="XM_009172890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABR7"/>
    <dbReference type="GeneID" id="20321565"/>
    <dbReference type="KEGG" id="ovi:T265_07386"/>
    <dbReference type="CTD" id="20321565"/>
    <dbReference type="OrthoDB" id="6152956at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39791" checksum="B32A51F5CA480F9D" modified="2014-10-01" version="1">MERVSSQIKQIGETADTTHHKDCYAPGLFTQKTPERFIEEKVGSSDSIDGRWFVRRAGQFGCKRVSTNRGNIISALLGGVAVDNHRFIATHPNNALMTSPQLVVKRLNSSYEAQRTNQRAFSGDSCLHMLQTHVIPQLKQHKKSSVVLQQDGAPPHCSNQLCPETTETEGPPEPPGDDTCDAPAADIRSHQTKETLVNIFTTERLLCAVYTSHNPWSPPEEEQMNRTLEQLSFNYHFKHLLLVGDFHAPKASCMELWCIESSGVFTAALIEVVKQSAWTQHVFAPTRYRAGQLPALLDLVITNERHFVDQVTINASLEHDHQCVLNLISSAIGREIPNPKRGFETPAGQNSQECASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC55</accession>
    <name>A0A075AC55_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162876.1">
        <property type="nucleotide sequence ID" value="XM_009164612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC55"/>
    <dbReference type="STRING" id="6198.A0A075AC55"/>
    <dbReference type="GeneID" id="20314951"/>
    <dbReference type="KEGG" id="ovi:T265_00763"/>
    <dbReference type="CTD" id="20314951"/>
    <dbReference type="OrthoDB" id="6017654at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009652">
        <property type="entry name" value="PDCD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053750">
        <property type="entry name" value="PDCD10_Homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250">
        <property type="entry name" value="TF-1 CELL APOPTOSIS RELATED PROTEIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06840">
        <property type="entry name" value="PDC10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="535" mass="61128" checksum="4BECCB8E85546105" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADA5</accession>
    <name>A0A075ADA5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170315.1">
        <property type="nucleotide sequence ID" value="XM_009172051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADA5"/>
    <dbReference type="GeneID" id="20328269"/>
    <dbReference type="KEGG" id="ovi:T265_14103"/>
    <dbReference type="CTD" id="20328269"/>
    <dbReference type="OrthoDB" id="6252565at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15453" checksum="82C69152DD491AF7" modified="2014-10-01" version="1">MNANVQDTADTSALVVPLTAFGCALSVFLIFLLIIVLDTMCRNRKLASAKYAGSKMFSMKPSSDIIPAESTEFVPSTSEEEETTEPQQPRVLSDVIIDQLEVAGANTGQYCVETTLDYGYEGEEDSVTESSRPGAKRPSAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEM6</accession>
    <name>A0A075AEM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EXTL2, alpha-1,4-N-acetylhexosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169343.1">
        <property type="nucleotide sequence ID" value="XM_009171079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEM6"/>
    <dbReference type="STRING" id="6198.A0A075AEM6"/>
    <dbReference type="GeneID" id="20320114"/>
    <dbReference type="KEGG" id="ovi:T265_05932"/>
    <dbReference type="CTD" id="20320114"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="9">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="10">
        <location>
            <begin position="273"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56767" checksum="DD3AF8088D8D0367" modified="2014-10-01" version="1">MLRGKYSVFSGKAIIAHATHSKWTYRPTFDVSIPAYNPLYDITPSSSAPVFRDTHILTVLPVANADPATIKQLLLAHRIPTFPGNASVLVLDPVLPQSRSYGTRSASLSISPYDPPSRTIVDYGEALVGSLFCLIIQIPPVGQFALFDSMSAGCIPVIADDNFILPFSEVLDWSKIAIRVRHSELHKIVTTLTSLSSQEIAQFQRQVKFIFNRYFSTIEKIVHTTLDIINDRVFPYYARSYVQWNSPDYMENALPPPPLLFYPPRSSVHGRLTALIRARDHFGLLHQLLLKLQLASSLHRIVVLWTNPRIPIPNPSLWPALRVPLTVLPFSQLLHGRYYPFAQIDTEAVLSLDDSTCLPDLQQIQAGFELWCHNPDRLIGLTNGTIVGSARKLSDEASSLSAVFGLTIFHKHYLHSYAELLSSMAIRPVNQTGACEELLMNWLIIQLSGRPVLTVRDSRLTPVSPASCHLQSSMACWTDLSATHPYFTTILSRGRAFRIAPWTVSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHQ7</accession>
    <name>A0A075AHQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165949.1">
        <property type="nucleotide sequence ID" value="XM_009167685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHQ7"/>
    <dbReference type="GeneID" id="20317439"/>
    <dbReference type="KEGG" id="ovi:T265_03252"/>
    <dbReference type="CTD" id="20317439"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10637" checksum="E800DAED3BE57AFC" modified="2014-10-01" version="1">MSSYVGFRHEETGPYRGVTSSIGRRRSRDTQSMAWQRNLKAVVSQISRVGNCRTTGGVKQMFIRHGEYVAQPTMLLHQSHQLHFVAFTFYDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHZ2</accession>
    <name>A0A075AHZ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165497.1">
        <property type="nucleotide sequence ID" value="XM_009167233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHZ2"/>
    <dbReference type="GeneID" id="20317068"/>
    <dbReference type="KEGG" id="ovi:T265_02880"/>
    <dbReference type="CTD" id="20317068"/>
    <dbReference type="OrthoDB" id="6265014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF260">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="101325" checksum="C59502603B605646" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI45</accession>
    <name>A0A075AI45_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_02673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165239.1">
        <property type="nucleotide sequence ID" value="XM_009166975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI45"/>
    <dbReference type="STRING" id="6198.A0A075AI45"/>
    <dbReference type="GeneID" id="20316861"/>
    <dbReference type="KEGG" id="ovi:T265_02673"/>
    <dbReference type="CTD" id="20316861"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="69"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="311" mass="35261" checksum="B82C789FEC1EC2D3" modified="2014-10-01" version="1">MQVLSHLRRVTDSPSFDIGSNVTKLQVFLFGALFGSILVMLLMELNYERIPISVKPAPELSGPVNSSVKIFCWITTMPSNHGTKAIHIKATWAPRCDRYLFMSSVDLPELPAVAAVNREGRSYLWEKTAFALNYVWTHFGEEFDFFYKADDDTYALIDNLRLLLADYDPHTPVLIGQAHKSFLKQGYPSGGAGYVMSRAALRLIVQGMKNTSMCYDQRFSLAEDLKLGACAEELGIQLIHSVDENGHYHFYCYSPFERLKNHGLSAELTFDNHKEGTGCCARNPVSFHYIKPEELYFLDYLLYTARSRGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIT0</accession>
    <name>A0A075AIT0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164135.1">
        <property type="nucleotide sequence ID" value="XM_009165871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIT0"/>
    <dbReference type="GeneID" id="20315969"/>
    <dbReference type="KEGG" id="ovi:T265_01781"/>
    <dbReference type="CTD" id="20315969"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13491" checksum="439C3548C7B2375B" modified="2014-10-01" version="1">MSHAFILADQTDAIGFIRSDCTIPRGGTLCTNRRATCNISRYMHIRIALLIRLLKILRQSTTGFALLEAHQCCTQAASCFSWHDIRSIAVYFHKENYSQGCWKLFDSPRPVSPFLGPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJL0</accession>
    <name>A0A075AJL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162760.1">
        <property type="nucleotide sequence ID" value="XM_009164496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJL0"/>
    <dbReference type="GeneID" id="20314856"/>
    <dbReference type="KEGG" id="ovi:T265_00668"/>
    <dbReference type="CTD" id="20314856"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11959" checksum="78692A0563EA7E35" modified="2014-10-01" version="1">MTLWQEENGTITIAVVQIAFRELRALLIRLLKIRRQPSTGFALLGAHQGTAHNVAENSSTAHDRFRPSWVSSGRRSPRVSVNPKWTVFEEYTHLQINLAFTRDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJN1</accession>
    <name>A0A075AJN1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162624.1">
        <property type="nucleotide sequence ID" value="XM_009164360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJN1"/>
    <dbReference type="GeneID" id="20314744"/>
    <dbReference type="KEGG" id="ovi:T265_00556"/>
    <dbReference type="CTD" id="20314744"/>
    <dbReference type="OrthoDB" id="6264573at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="382" mass="43040" checksum="00A6B544D827A1F4" modified="2014-10-01" version="1">MFTESGVQPRRTFTLPMYTFGSSCYPTSSELCPRLTTPIRIPGVYATSTPMATSTVSVNPGRARRGRRSTIPPEQREKTRRVSKIHFPWKWKHMHSELSLCFFEVSKQSIFANTGFIVPPCPYPFQQLKKQDMERRRRACISDKMNALHNLAMNIIGLDAHQQQKQEKADILNTCYKVFEAIAQIVHEEPELQTRIHQLRSICNAPEPSAGTSLPPDENTQSSAFSDDLQSSDSEHSYPASRTSEMKENRSQSPSFGYQSTHSRKPLTEVHMNIRNETNSSCNTCTDGSRLYDSGICNSFGENISVPGSSTHHQATHKFNPKTDMSRKPRISLEKPPLQHLSPCTELKFTGSQVTPSNSSAFRVVQGADIKPVSNSVWRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJZ2</accession>
    <name>A0A075AJZ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162008.1">
        <property type="nucleotide sequence ID" value="XM_009163744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJZ2"/>
    <dbReference type="GeneID" id="20314275"/>
    <dbReference type="KEGG" id="ovi:T265_00087"/>
    <dbReference type="CTD" id="20314275"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8194" checksum="2B1D0ADAB4F5EED6" modified="2014-10-01" version="1">MTLMGTQIADLRPPRPTEPADPVRGPAQPVAEFLHNDSPASKQEGSCVCQRVTTDCNRLEAERFEATSTTCVFGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTD6</accession>
    <name>A0A074YTD6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL622798">
        <property type="protein sequence ID" value="KER17988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178265.1">
        <property type="nucleotide sequence ID" value="XM_009180001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTD6"/>
    <dbReference type="STRING" id="6198.A0A074YTD6"/>
    <dbReference type="GeneID" id="20330538"/>
    <dbReference type="KEGG" id="ovi:T265_16373"/>
    <dbReference type="CTD" id="20330538"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER17988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10363" checksum="CD8BA38283E04D0A" modified="2014-10-01" version="1" fragment="single">MASAGENSMRKQMSITRRRHRRRLTVRNNRFRFSSTNTNKHAHQTRLNNFSKDVISDNTTTADNSDSDAVYLVEDIIGEKIVKGQKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU00</accession>
    <name>A0A074YU00_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607078">
        <property type="protein sequence ID" value="KER18183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178070.1">
        <property type="nucleotide sequence ID" value="XM_009179806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU00"/>
    <dbReference type="GeneID" id="20330401"/>
    <dbReference type="KEGG" id="ovi:T265_16236"/>
    <dbReference type="CTD" id="20330401"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="20741" checksum="4495E4BED4C0BC39" modified="2014-10-01" version="1" fragment="single">MDGQPQGNPVFYGTQPSPALSFNHWVEHTNAQPPSPDLFSDTAVDEDFWTSHQPNPQEADTIPVPQTPPIQYRPPMLDLSNVWHSKRRQLFSPEPSIQDNNKLWTFVYRGQPPRFERGTRVNHWNTQMPNHQVPICSRIQRWTKISGPLTNLTPKKRTQYQSRKPHQSNTDHLCWISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW35</accession>
    <name>A0A074YW35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="KL597402">
        <property type="protein sequence ID" value="KER18986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177268.1">
        <property type="nucleotide sequence ID" value="XM_009179004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW35"/>
    <dbReference type="STRING" id="6198.A0A074YW35"/>
    <dbReference type="GeneID" id="20326236"/>
    <dbReference type="KEGG" id="ovi:T265_12068"/>
    <dbReference type="CTD" id="20326236"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705230" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="138"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER18986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="433" mass="48471" checksum="42D3373E9D2DABC1" modified="2014-10-01" version="1">MDVRELGYFPVYSLLCFLCPVLGLYSSNDDVIELTPSTFNRVTSDDSVWFVEFYAPWCGHCKNLAPEWKQAATALKGVVKLAAVNADEHSSLANTYNVKGFPTILMFVKDKHKTSTPYTGGRQASHIVKEALDQVKKLVESRMGQESSQSGGGSGRTDVVELTDNNFEDVVLKSEEPWLVEFFAPWCGHCKNLKPHWETAATELKGVMKVGAVDATVHNQLSQKYGIRGFPTIKFFPAGSKKNTDPVDYDGGRTSDDIVRWAMDKAEASMPDPELTEITSSAVFSDACEKHQICVISVLPSLYDCQSDCRNQHLNTIKQQAAEYKKQKWGWVWTEALKQPELEKMFDIGGAGYPAMVAVHSKKLKRATLRGSFSTEGIHDFLRSLLHGDPQLQLFPVRELPKILTVDPWDGNDAPPIEEDEIDWEEMGIKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXC9</accession>
    <name>A0A074YXC9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FF domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_15534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597203">
        <property type="protein sequence ID" value="KER19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176792.1">
        <property type="nucleotide sequence ID" value="XM_009178528.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YXC9"/>
    <dbReference type="GeneID" id="20329699"/>
    <dbReference type="KEGG" id="ovi:T265_15534"/>
    <dbReference type="CTD" id="20329699"/>
    <dbReference type="OrthoDB" id="63972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000001">
        <property type="entry name" value="Transcription elongation regulator 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057565">
        <property type="entry name" value="WW_TCRG1_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23517">
        <property type="entry name" value="WW_TCERG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="10">
        <location>
            <begin position="428"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="10">
        <location>
            <begin position="495"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="10">
        <location>
            <begin position="563"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="10">
        <location>
            <begin position="670"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="482"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1566" mass="174157" checksum="245218C72E8291F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYX8</accession>
    <name>A0A074YYX8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KER19873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176379.1">
        <property type="nucleotide sequence ID" value="XM_009178115.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20325626"/>
    <dbReference type="KEGG" id="ovi:T265_11458"/>
    <dbReference type="CTD" id="20325626"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="11">
        <location>
            <begin position="1518"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1920" mass="209656" checksum="F589265CBC6FA1D3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZM7</accession>
    <name>A0A074YZM7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597077">
        <property type="protein sequence ID" value="KER20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176028.1">
        <property type="nucleotide sequence ID" value="XM_009177764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZM7"/>
    <dbReference type="GeneID" id="20325342"/>
    <dbReference type="KEGG" id="ovi:T265_11174"/>
    <dbReference type="CTD" id="20325342"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13177" checksum="61675BCFD3F6EF67" modified="2014-10-01" version="1">MKDITKGLGAVGATCLPEWGPDGLHWAWLETFRKSRAQEERNSHHYSSANTPILTMIDPWGKGPQEYNRYNSCSTLSVPNCHPTRRKHEGQDTARLPRPRQGKSRGRGQGSDHGPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z061</accession>
    <name>A0A074Z061_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597069">
        <property type="protein sequence ID" value="KER20308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175946.1">
        <property type="nucleotide sequence ID" value="XM_009177682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z061"/>
    <dbReference type="GeneID" id="20325284"/>
    <dbReference type="KEGG" id="ovi:T265_11116"/>
    <dbReference type="CTD" id="20325284"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11172" checksum="190EFE10851A6366" modified="2014-10-01" version="1">MPLRELLGLVLNVVSLKEQLPTLEQTKIKKEALERHLKLETLGMTVRQSNTEIKLEPSSEPINESENGEVRSKSTLADTQNQTGRKPDFTVELEMARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0D4</accession>
    <name>A0A074Z0D4_OPIVI</name>
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        <recommendedName>
            <fullName evidence="7">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">T265_15324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597061">
        <property type="protein sequence ID" value="KER20393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175850.1">
        <property type="nucleotide sequence ID" value="XM_009177586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0D4"/>
    <dbReference type="STRING" id="6198.A0A074Z0D4"/>
    <dbReference type="GeneID" id="20329489"/>
    <dbReference type="KEGG" id="ovi:T265_15324"/>
    <dbReference type="CTD" id="20329489"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59914" checksum="B5A6335ECC6165CC" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0R2</accession>
    <name>A0A074Z0R2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_15277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175640.1">
        <property type="nucleotide sequence ID" value="XM_009177376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0R2"/>
    <dbReference type="STRING" id="6198.A0A074Z0R2"/>
    <dbReference type="GeneID" id="20329442"/>
    <dbReference type="KEGG" id="ovi:T265_15277"/>
    <dbReference type="CTD" id="20329442"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF533">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE VHP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="317"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="916" mass="99918" checksum="2C3F356871596D6F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z141</accession>
    <name>A0A074Z141_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597299">
        <property type="protein sequence ID" value="KER19182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177076.1">
        <property type="nucleotide sequence ID" value="XM_009178812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z141"/>
    <dbReference type="GeneID" id="20326131"/>
    <dbReference type="KEGG" id="ovi:T265_11963"/>
    <dbReference type="CTD" id="20326131"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="16197" checksum="6A6DA78F64DD80F4" modified="2014-10-01" version="1">MHITVNSLEFSLQHTVWHTLEHYFIGVKCAFDYWRVRRPQSSQTPETQLNEIIPSTKPVPPPQEYYGHDPYYNHDDCGPKVKIIQQIPGEPPSNYSDEEQEADDPKCIQRSGASGSLHPTTIDPESKPTSIITRRLPNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2G1</accession>
    <name>A0A074Z2G1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597157">
        <property type="protein sequence ID" value="KER19677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176579.1">
        <property type="nucleotide sequence ID" value="XM_009178315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2G1"/>
    <dbReference type="GeneID" id="20325783"/>
    <dbReference type="KEGG" id="ovi:T265_11615"/>
    <dbReference type="CTD" id="20325783"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="8096" checksum="887642ACE0F17663" modified="2014-10-01" version="1">MMRKAVKLSISNDKPKLDVVYEKQILQKNIVHLEHPVEHNRKHKVFRKAPKGFPSTATVDKSSNKTNFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2N9</accession>
    <name>A0A074Z2N9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596982">
        <property type="protein sequence ID" value="KER21228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175017.1">
        <property type="nucleotide sequence ID" value="XM_009176753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2N9"/>
    <dbReference type="STRING" id="6198.A0A074Z2N9"/>
    <dbReference type="GeneID" id="20324557"/>
    <dbReference type="KEGG" id="ovi:T265_10389"/>
    <dbReference type="CTD" id="20324557"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="486" mass="53756" checksum="76BA703407A0DBF2" modified="2014-10-01" version="1">MDFQHRAGGKTGSGGVASDAEANRDRRERLRQLALDTIDLNKDPYFMKNHLGTYECKLCLTLHNNEGSYLAHTQGKKHQYNLQRRAVEQAREAPATMQPERIKIEPKKFIKIGRPGYKVTKQKDPETGQQSMLFQIDYPEIADSVGVQPRHRFMSAYEQRVEPPDRRWQYLLFAAEPYETIAFKIPSREVDKDPKKLWTYWNPSVKQFFLQPTGEVEPWTVNVEPPTASEVYDCICSLKRHRAPGPDDLPPALFKDGGEVLSQHLSDLFACIWEKESVPDNWGESVIVPIFKKGARSECRNHRGISLTTVVTRLLASIVIRRLTVAREILTREQQAAPCHKALLFAYKLEGQSHSAAMLRDLEMQKARAQQAQLQLQLPPPPPPPPPPPPQVIGLPPPGPGFMFGMDSVPVSMPPPPPPPPALSKDATGGGLLPPPPPPPPPSVSSAGFPAPPPPPPPPPPPPVALLSTPANLPPPPPPPPPPGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Q4</accession>
    <name>A0A074Z2Q4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Otopetrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_15458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176469.1">
        <property type="nucleotide sequence ID" value="XM_009178205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Q4"/>
    <dbReference type="STRING" id="6198.A0A074Z2Q4"/>
    <dbReference type="GeneID" id="20329623"/>
    <dbReference type="KEGG" id="ovi:T265_15458"/>
    <dbReference type="CTD" id="20329623"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="21"/>
            <end position="758"/>
        </location>
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        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="613"/>
            <end position="633"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="703"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="86405" checksum="8132A2DEFF00A9E5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z352</accession>
    <name>A0A074Z352_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="AlphaFoldDB" id="A0A074Z352"/>
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    <dbReference type="KEGG" id="ovi:T265_10251"/>
    <dbReference type="CTD" id="20324419"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12518" checksum="8A80FA4FF2963865" modified="2014-10-01" version="1">MAVRLGPFEQRDRDVYRCSTIVFSEPKLVWVRAGKSTSKRLESEFSVVPRILPLSDMFSTRSCVGWDICYLSQLTDTRKESIPAATNRKHCAVFMISWIKGHTQNHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3R5</accession>
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        <recommendedName>
            <fullName evidence="4">Integrator complex subunit 7</fullName>
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        <lineage>
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            <taxon>Digenea</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 7 family.</text>
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        <property type="nucleotide sequence ID" value="XM_009176273.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="INTS7"/>
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    </dbReference>
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        <property type="entry name" value="INTS7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322">
        <property type="entry name" value="C1ORF73 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 7"/>
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    </dbReference>
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        <property type="entry name" value="INTS7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTS7_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTS7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 helical bundle" evidence="10">
        <location>
            <begin position="560"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 C-terminal" evidence="8">
        <location>
            <begin position="844"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114943" checksum="DD233D7E261C7832" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Z0</accession>
    <name>A0A074Z3Z0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL615455">
        <property type="protein sequence ID" value="KER18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178213.1">
        <property type="nucleotide sequence ID" value="XM_009179949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Z0"/>
    <dbReference type="STRING" id="6198.A0A074Z3Z0"/>
    <dbReference type="GeneID" id="20330505"/>
    <dbReference type="KEGG" id="ovi:T265_16340"/>
    <dbReference type="CTD" id="20330505"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9287" checksum="0D84F78344A64D1C" modified="2014-10-01" version="1" fragment="single">DDQRASLPAFPGLRAGPGLQLLESSSLSNIHGVMFTSTGSGASDGLPEPQSRPFSVTRFQRATSSAAAASGTPLEPDAEFLDMILRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5F9</accession>
    <name>A0A074Z5F9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596903">
        <property type="protein sequence ID" value="KER22366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173898.1">
        <property type="nucleotide sequence ID" value="XM_009175634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5F9"/>
    <dbReference type="GeneID" id="20323704"/>
    <dbReference type="KEGG" id="ovi:T265_09535"/>
    <dbReference type="CTD" id="20323704"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="138" mass="15196" checksum="A37EB2A7B1308975" modified="2014-10-01" version="1">MSLTGDLYDKYTVGGPLSCNSPESAMNRSVLGQIVIGFIIHYDLCDPPSSSQPDPSMGFNTKLGNGWFGGTKVLYVVLLHCRTSLMEASIYNLTQERTPATDDDDDDNDDDDDDDDDDDDDDDGDDDGREDEQSIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6K4</accession>
    <name>A0A074Z6K4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596989">
        <property type="protein sequence ID" value="KER21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175097.1">
        <property type="nucleotide sequence ID" value="XM_009176833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6K4"/>
    <dbReference type="GeneID" id="20329320"/>
    <dbReference type="KEGG" id="ovi:T265_15155"/>
    <dbReference type="CTD" id="20329320"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23347" checksum="B84CB3EA91AC9A39" modified="2014-10-01" version="1" fragment="single">MDAPALHQTEFPDGLVTSGAEDLAEIASSDEESTVAAIQGDEQQYEADNEEENMFQPSLADIFRDWMILTNAPFSTRKVPVQRRLLGSVYIHLEGTGIGTPGFQVVHKMKTWSCKNIWKGTDVDQKQQWSLDGAFRNSNRDRRWRRVPNCKSSAGFDVPKLHPGLWRAEVAYKQVKWYLEEICSGPLIRPDIIGSGFAYLEWGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7I2</accession>
    <name>A0A074Z7I2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_08967</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="KL596866">
        <property type="protein sequence ID" value="KER23068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173178.1">
        <property type="nucleotide sequence ID" value="XM_009174914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7I2"/>
    <dbReference type="SMR" id="A0A074Z7I2"/>
    <dbReference type="STRING" id="6198.A0A074Z7I2"/>
    <dbReference type="GeneID" id="20323146"/>
    <dbReference type="KEGG" id="ovi:T265_08967"/>
    <dbReference type="CTD" id="20323146"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER23068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="589" mass="65621" checksum="0244E5558D1CABCF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Y2</accession>
    <name>A0A074Z7Y2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KL596860">
        <property type="protein sequence ID" value="KER23198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173051.1">
        <property type="nucleotide sequence ID" value="XM_009174787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Y2"/>
    <dbReference type="STRING" id="6198.A0A074Z7Y2"/>
    <dbReference type="GeneID" id="20328851"/>
    <dbReference type="KEGG" id="ovi:T265_14685"/>
    <dbReference type="CTD" id="20328851"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="398"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="611"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1109" mass="126631" checksum="FE02A7522AD2D81F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Q1</accession>
    <name>A0A074Z8Q1_OPIVI</name>
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        <submittedName>
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        </submittedName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="ovi:T265_11674"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16229" checksum="96AD27CB080C2A21" modified="2014-10-01" version="1">MSEPTVKLGTSLMAPTTQHLGETRRLPKSEEVACYEAVSRQFQAECITIQLGEAENGERNFADIPWSERSHKNTPQPTNSTSKHTNDRSLIILGVPEPNETSNKVAQNTHDYMQLQCLCSTLELINVAVVDTFQNHQSIWVPAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA89</accession>
    <name>A0A074ZA89_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7391" checksum="5BEC603D0CD2C3BF" modified="2014-10-01" version="1">MGTLRRAISMVRNILRHGPVELSMAFHNSQAHHSHNFEPQMAENPVEKRFVHSSALVLLTKAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAU8</accession>
    <name>A0A074ZAU8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597063">
        <property type="protein sequence ID" value="KER20365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175877.1">
        <property type="nucleotide sequence ID" value="XM_009177613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAU8"/>
    <dbReference type="STRING" id="6198.A0A074ZAU8"/>
    <dbReference type="GeneID" id="20325230"/>
    <dbReference type="KEGG" id="ovi:T265_11062"/>
    <dbReference type="CTD" id="20325230"/>
    <dbReference type="OrthoDB" id="6140671at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="468" mass="55526" checksum="39108110784BC557" modified="2014-10-01" version="1">MRVKYRIRHTPFSEWRHYFGCVISFVTFGLILLSFVTPYWLQSWSRLHTPFLRLGLWEFCLKGFMERVDQGMVSYFDCWWILSPYYSKIFAELVPFWFIIIQVLMSVSLAIQVVLFVLLIVYLCERIRHVERRIFSINMMAVGHALTASVRMRVKYRIRHTPFSEWRHYFGCVISFVTFGLILLSFVTPYWLQSWSRLHTPFLRLGLWEFCLKGFMERVDQGMVSYFDCWWILSPYYSKIFAELVPFWFIIIQVLMSVSLAIQVVLFVLLIVYLCERIRHVERRIFSINMMAVGHALTACALFPALVVFGVNWKNPNWMPYPKFNWPSWSYGAAILANFSSLCGALCFGLVSRELRRDLEEYTMEFPMSTKLKHRRRWWLRKRRWSQDVEAPGSKPHYEFEKRLTPTPRPDEMISMSEFSQSHAQSVSQQDNSLGSPESDSQPRSFESPSSSMREHRPLVGQRYGSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB04</accession>
    <name>A0A074ZB04_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171934.1">
        <property type="nucleotide sequence ID" value="XM_009173670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB04"/>
    <dbReference type="STRING" id="6198.A0A074ZB04"/>
    <dbReference type="GeneID" id="20322168"/>
    <dbReference type="KEGG" id="ovi:T265_07989"/>
    <dbReference type="CTD" id="20322168"/>
    <dbReference type="OrthoDB" id="77463at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046856">
        <property type="entry name" value="Gemin6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046857">
        <property type="entry name" value="Gemin6_Sm-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06372">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20417">
        <property type="entry name" value="Gemin6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="19029" checksum="5A60F360C8ECA9CD" modified="2014-10-01" version="1">MHHSSTFTALLDKRVKFHCQYDRCFEGYVYAVDPESGNCVIYENPEKGENLPTVICAWAIKFTEVIEDELPEKVRGFFDGLHSIETGNDVEDRSNPLPSSESFEERRKHLIDLFQANFIELKPEMNDVFSVNGVVFIHPPYTIDTCSSTNVVALDRVKKLLRSIGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBK5</accession>
    <name>A0A074ZBK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596870">
        <property type="protein sequence ID" value="KER22982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173254.1">
        <property type="nucleotide sequence ID" value="XM_009174990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBK5"/>
    <dbReference type="GeneID" id="20323205"/>
    <dbReference type="KEGG" id="ovi:T265_09026"/>
    <dbReference type="CTD" id="20323205"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8564" checksum="C879291EBE70929E" modified="2014-10-01" version="1">MAVEALFTASRVAGVFNKEKGAITRLPSVMWGWPNPDPKPTTNQLLRSWRIKPPESNGYVVIAGHLFSVVCDVIGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBM4</accession>
    <name>A0A074ZBM4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171578.1">
        <property type="nucleotide sequence ID" value="XM_009173314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBM4"/>
    <dbReference type="GeneID" id="20321897"/>
    <dbReference type="KEGG" id="ovi:T265_07718"/>
    <dbReference type="CTD" id="20321897"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8567" checksum="B9B42815B86B0E67" modified="2014-10-01" version="1">MDLKIKNLEYPKSSRLPRDCLSNLLHSFGYLELLLPICTHTILSAVAPFRCLAVMPPERSTRAGILLGCPSLDRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBM9</accession>
    <name>A0A074ZBM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171713.1">
        <property type="nucleotide sequence ID" value="XM_009173449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBM9"/>
    <dbReference type="GeneID" id="20321999"/>
    <dbReference type="KEGG" id="ovi:T265_07820"/>
    <dbReference type="CTD" id="20321999"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9333" checksum="B0051737A0788E26" modified="2014-10-01" version="1">MPHGGGTRAGILPGRPSLDRGNREAEVGFEPRTFRIWHSNLTLLYLLICQSEVSAVDPLQCLVPEKDSQKGTRQLYVEQASLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC24</accession>
    <name>A0A074ZC24_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="9">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_07589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="9"/>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171410.1">
        <property type="nucleotide sequence ID" value="XM_009173146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC24"/>
    <dbReference type="STRING" id="6198.A0A074ZC24"/>
    <dbReference type="GeneID" id="20321768"/>
    <dbReference type="KEGG" id="ovi:T265_07589"/>
    <dbReference type="CTD" id="20321768"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="36356" checksum="213D4A6C8E092D0F" modified="2014-10-01" version="1">MPKPKVGINGFGRIGRLVLRAAIDKGTVEVVAVNDPFIDLNYMKYMFKYDSTHGVFPSDVCVVGGNLMVKGMTIAVHNERDPAAIPWGSHQAEYIVESTGVFTTIDKAKAHLQGGAKKVIISAPSADAPMFVVGVNHQTYHKGLDVVSNASCTTNCLAPLAKVVHEKYGILEGLMTTVHAYTATQKTVDGPSNKDWRGGRGAHQNIIPSSTGAAKAVGKVIPDLNGKLTGMAFRVPTPDVSVVDLTCRLSKPAKYTEIMETIKHASEGPMKGILDYTEDEVVSMDFRGSSASSIFDAKAGIQLSDTFVKLVAWYDNEYGYSCRVVDLISHMYSVDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC41</accession>
    <name>A0A074ZC41_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171564.1">
        <property type="nucleotide sequence ID" value="XM_009173300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC41"/>
    <dbReference type="STRING" id="6198.A0A074ZC41"/>
    <dbReference type="GeneID" id="20328526"/>
    <dbReference type="KEGG" id="ovi:T265_14360"/>
    <dbReference type="CTD" id="20328526"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="99271" checksum="C8F763CF1E0D483A" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC47</accession>
    <name>A0A074ZC47_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173111.1">
        <property type="nucleotide sequence ID" value="XM_009174847.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZC47"/>
    <dbReference type="GeneID" id="20323095"/>
    <dbReference type="KEGG" id="ovi:T265_08916"/>
    <dbReference type="CTD" id="20323095"/>
    <dbReference type="OrthoDB" id="6243118at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="629"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="480"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="590"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1838"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1931"/>
            <end position="1986"/>
        </location>
    </feature>
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            <begin position="122"/>
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        </location>
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        <location>
            <begin position="156"/>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
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        </location>
    </feature>
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            <begin position="273"/>
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    </feature>
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        <location>
            <begin position="487"/>
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        </location>
    </feature>
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        </location>
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        <location>
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            <position position="658"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23147.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1986" mass="215447" checksum="D73864D80E80B95F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCV0</accession>
    <name>A0A074ZCV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_15188</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009176979.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial protein catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitophagy by internal vacuole formation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <position position="354"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="39158" checksum="637C4E0F382386FF" modified="2014-10-01" version="1" fragment="single">MSIFSAEEKPSDNKACKPPCEKSPGGSDPVVTQLEPSFVGSELKSLEQENERLQNKLIQADQGARRSAQPTGKSGTRASDSLEAYSGERISGNTHGSLNGISPLSTHDPIQRSRQQLVVMRFNELFSGGRIEAMNLLRRYSNDHDMNQSIVFNAIMESFNVARAHFRAYRNRLRTKMATTTNPPSSETLDELVQSHINVHGSFAANLPAMTQEVLLAMEQHSPRLQSPSEALGFEIIGDFIHEACKLAWECSVLAHPIDVYRPAFANEVARVRCLVVGLFAELGSWIANVSPTQPCTDDVTSIGDETYRRSHDSSYSAVLVHHHIWPCLVQDGSVIAKGEVCTRRGRPSYSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDY6</accession>
    <name>A0A074ZDY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter, ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_15097</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596969">
        <property type="protein sequence ID" value="KER21410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174836.1">
        <property type="nucleotide sequence ID" value="XM_009176572.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZDY6"/>
    <dbReference type="GeneID" id="20329262"/>
    <dbReference type="KEGG" id="ovi:T265_15097"/>
    <dbReference type="CTD" id="20329262"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1318"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1388"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1495"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1624"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="580"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="895"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1328"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1718"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2010" mass="224205" checksum="31E1763151997FE4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEA1</accession>
    <name>A0A074ZEA1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170761.1">
        <property type="nucleotide sequence ID" value="XM_009172497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEA1"/>
    <dbReference type="GeneID" id="20321247"/>
    <dbReference type="KEGG" id="ovi:T265_07068"/>
    <dbReference type="CTD" id="20321247"/>
    <dbReference type="OrthoDB" id="10418435at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8098" checksum="5E8986F0247B32A2" modified="2014-10-01" version="1" fragment="single">AGIRCANGTVRDELNNRVITYEDGCRFCKFIKYGAGNDYEYKCEKGNLWENKAGDYCCEHKDCNLSESLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG48</accession>
    <name>A0A074ZG48_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169980.1">
        <property type="nucleotide sequence ID" value="XM_009171716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG48"/>
    <dbReference type="GeneID" id="20320627"/>
    <dbReference type="KEGG" id="ovi:T265_06448"/>
    <dbReference type="CTD" id="20320627"/>
    <dbReference type="OrthoDB" id="6283122at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43505" checksum="5B32C36A8CA72A05" modified="2014-10-01" version="1">MCGWNNDLNSWNYRWTLAREPSAAASSPRLYPSSVNESYCCFSVKQTEMALNSPVMTDDYSAWLVTPRPARVQLPQTMDSESVLQSRLWSPAIPGTMQLKCLAFSFHIKLGRAIKEKLPVDPIHVCSFQSDTCGWTNDPNSWKHRWELDRLSVDDDQALCLSSVSKFSSGPISMASPWDFASDEMEANRPAHSGPIQARLWSPPIQKRHKLGCLTVLYQIHGSPATAIVDGTQKPDASLDRLGLALLRRQEGFTVNVSFLFSEITPIHVCTFASDTCGWTNDQNSWKHRWELDPISFGKNQALCLSSVSQVPTSVALPWAVSADEAVLDALHHSSPIQGRLWSPPIQKRHKLGCFAFLYRIDSKSHIVSGIQGTEQSDPLPGLAVLSRQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG74</accession>
    <name>A0A074ZG74_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fanconi anemia group M protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170081.1">
        <property type="nucleotide sequence ID" value="XM_009171817.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZG74"/>
    <dbReference type="GeneID" id="20320713"/>
    <dbReference type="KEGG" id="ovi:T265_06534"/>
    <dbReference type="CTD" id="20320713"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="124"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="479"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1230"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1442" mass="158284" checksum="F67DEEB7371C4F9D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGM5</accession>
    <name>A0A074ZGM5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 14 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169784.1">
        <property type="nucleotide sequence ID" value="XM_009171520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGM5"/>
    <dbReference type="STRING" id="6198.A0A074ZGM5"/>
    <dbReference type="GeneID" id="20320475"/>
    <dbReference type="KEGG" id="ovi:T265_06293"/>
    <dbReference type="CTD" id="20320475"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="41" mass="4588" checksum="0A0BBC8C8489826E" modified="2014-10-01" version="1">MNRFNQAYSNLLKASIDGLKKRDKRIKAAPAKSGRPKTEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGQ3</accession>
    <name>A0A074ZGQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169805.1">
        <property type="nucleotide sequence ID" value="XM_009171541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGQ3"/>
    <dbReference type="STRING" id="6198.A0A074ZGQ3"/>
    <dbReference type="GeneID" id="20320496"/>
    <dbReference type="KEGG" id="ovi:T265_06314"/>
    <dbReference type="CTD" id="20320496"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000054">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="470"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="731" mass="80781" checksum="B8E544443419B202" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHG3</accession>
    <name>A0A074ZHG3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin head</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596886">
        <property type="protein sequence ID" value="KER22660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173575.1">
        <property type="nucleotide sequence ID" value="XM_009175311.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZHG3"/>
    <dbReference type="GeneID" id="20323456"/>
    <dbReference type="KEGG" id="ovi:T265_09283"/>
    <dbReference type="CTD" id="20323456"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 5" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1541"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1565"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2152" mass="242969" checksum="5AB33F914399F41F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI02</accession>
    <name>A0A074ZI02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173344.1">
        <property type="nucleotide sequence ID" value="XM_009175080.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZI02"/>
    <dbReference type="GeneID" id="20323274"/>
    <dbReference type="KEGG" id="ovi:T265_09095"/>
    <dbReference type="CTD" id="20323274"/>
    <dbReference type="OrthoDB" id="10261013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="8">
        <location>
            <begin position="104"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122092" checksum="C0CBD4D8D64A0B0E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZID3</accession>
    <name>A0A074ZID3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170701.1">
        <property type="nucleotide sequence ID" value="XM_009172437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZID3"/>
    <dbReference type="STRING" id="6198.A0A074ZID3"/>
    <dbReference type="GeneID" id="20321195"/>
    <dbReference type="KEGG" id="ovi:T265_07016"/>
    <dbReference type="CTD" id="20321195"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="320"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="471" mass="52600" checksum="85FAE257A9C7CD7C" modified="2014-10-01" version="1">MKSRSEQYRGESLLSYFHSKFSETSISFNGGATSNLKIDTHGSKSIRVRPVKQKASDPPAFQKYTKSKPCPFYKWIPDTPLTVDAFNYGVIKGCEAYILSHFHSDHYNGLSASFPGTIYCSAVRRLNNFLSTQVTKSLVRIKFGGNLKVVAIPLNESFPICGIDVVAMDANHCPGSVMFLFHLKSMKRFILHTGDFRFHLDMLLPPSPLADIVGMHLIPVSGKAIPQLHTVYLDTTYCSSQYDFPPQQVIIAGAVEVTRVQLEKYPNTVVVCGMYTLGKERFVYGLASELNLRVWLHRNQHQLVSTAALNGCTVCASLMAHVVSNQQRAQLHVLPMAQLGMSSLIQYRTTLGPSNDQTPFNSPSNVNRPRPLVAWRPTGWSHQTGAKTNKLLQTTLDSSKPLPEGIRLQQCNDNIRIYGAAYSEHSSYSELKRFITHLRPNHVQPTVFGSAARGCQLEIESWLENHSPTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIG0</accession>
    <name>A0A074ZIG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170666.1">
        <property type="nucleotide sequence ID" value="XM_009172402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIG0"/>
    <dbReference type="GeneID" id="20321164"/>
    <dbReference type="KEGG" id="ovi:T265_06985"/>
    <dbReference type="CTD" id="20321164"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11312" checksum="EC437E9A0AEAD25D" modified="2014-10-01" version="1">MHFENLDVSQGEVSPPLYQTGMLEKRMDDYGTARVRNPNKLVTFRPCVGALQTSGCRLEGIFVVKVVDDGLRKLCRPEEEEETAVVAVSTGADIGGLSEPPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIY5</accession>
    <name>A0A074ZIY5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170560.1">
        <property type="nucleotide sequence ID" value="XM_009172296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIY5"/>
    <dbReference type="STRING" id="6198.A0A074ZIY5"/>
    <dbReference type="GeneID" id="20328329"/>
    <dbReference type="KEGG" id="ovi:T265_14163"/>
    <dbReference type="CTD" id="20328329"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="46"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="298" mass="34892" checksum="9FAEBE49A1783593" modified="2014-10-01" version="1" fragment="single">MTNDQCTPEYWFWIGTAFYSCFLLNEIIVPYFSGLWFKNYDQLKRPLYFEWNGRCTSTFHAIVVCTCSIWCLLFHDELWTNKLFNTDCLSRNTLAVSCGYMIYDLITMIWYSRGVPLLTYIVHHLVVIIGDILILKHNFGMFYVHYKLLTELSTPLVNLRWFILRVGYSPKHPAFSLTTLALCACFVTVRLIGSIPYWVWLQQSVTSLTDPDQIKTCETYKPVFYVLSILLDCLNVAWSSILVFRAMRSLKDLKVHYRSKQHNGEISFEQTYEIELNLFYNARLLISSNIAESSDGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ18</accession>
    <name>A0A074ZJ18_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">NADP(+)-specific ICDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_05892</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169285.1">
        <property type="nucleotide sequence ID" value="XM_009171021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ18"/>
    <dbReference type="STRING" id="6198.A0A074ZJ18"/>
    <dbReference type="GeneID" id="20320074"/>
    <dbReference type="KEGG" id="ovi:T265_05892"/>
    <dbReference type="CTD" id="20320074"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000022">
        <property type="entry name" value="Isocitrate dehydrogenase (NADP(+)) 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="48"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="584" mass="65799" checksum="E2FDD4BE10AAFB57" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJJ1</accession>
    <name>A0A074ZJJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170306.1">
        <property type="nucleotide sequence ID" value="XM_009172042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJJ1"/>
    <dbReference type="GeneID" id="20320887"/>
    <dbReference type="KEGG" id="ovi:T265_06708"/>
    <dbReference type="CTD" id="20320887"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="14133" checksum="ADE0953B8674BFC2" modified="2014-10-01" version="1">MSAFGQPDIISVLVLPPNGLVAIHRKSVTVKRLLIIYLFNLTGEVEPWTVNVEPPTASENGLSLNLRGRVYQATVRAVLLYDCEIWPIRAADLRRLQVFDNRCLRTIARVGWCRGMCNEAVSGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKD0</accession>
    <name>A0A074ZKD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_06485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170023.1">
        <property type="nucleotide sequence ID" value="XM_009171759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKD0"/>
    <dbReference type="STRING" id="6198.A0A074ZKD0"/>
    <dbReference type="GeneID" id="20320664"/>
    <dbReference type="KEGG" id="ovi:T265_06485"/>
    <dbReference type="CTD" id="20320664"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="470"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1091" mass="119927" checksum="524F2C61066FCF84" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL07</accession>
    <name>A0A074ZL07_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168187.1">
        <property type="nucleotide sequence ID" value="XM_009169923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL07"/>
    <dbReference type="STRING" id="6198.A0A074ZL07"/>
    <dbReference type="GeneID" id="20319205"/>
    <dbReference type="KEGG" id="ovi:T265_05023"/>
    <dbReference type="CTD" id="20319205"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123547" checksum="4732983D776FC112" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMC3</accession>
    <name>A0A074ZMC3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169307.1">
        <property type="nucleotide sequence ID" value="XM_009171043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMC3"/>
    <dbReference type="STRING" id="6198.A0A074ZMC3"/>
    <dbReference type="GeneID" id="20320090"/>
    <dbReference type="KEGG" id="ovi:T265_05908"/>
    <dbReference type="CTD" id="20320090"/>
    <dbReference type="OrthoDB" id="6275914at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32613" checksum="E7337769053E055C" modified="2014-10-01" version="1">MDAFIEAFYAIDVDRSEHSTSLSYTETITLDELRDYMEKNNMDPAFIERWQEIFDPEHTGSITLNTFCEVLGLELNNIRGQFDAAESVKHSASKQNDNDEELERSPPPQNGKLRQDDKDVEQARRKSSENADELNTWLEQKEPSSVAFVNGDTSKQISGESFDKIQVDETAPFSALRNGSDDTQKKFTENGSGCGNGYEEISVDIAEDLKTAIVRYAIEGLGQHQEDRDLVKWLKQRMDKEHGRLWHCTIVRGQYFSFYSYQPGHSFCFKIGPRIFIVFKTPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNQ7</accession>
    <name>A0A074ZNQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167536.1">
        <property type="nucleotide sequence ID" value="XM_009169272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNQ7"/>
    <dbReference type="GeneID" id="20318699"/>
    <dbReference type="KEGG" id="ovi:T265_04517"/>
    <dbReference type="CTD" id="20318699"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="14666" checksum="A12167B50843BE2B" modified="2014-10-01" version="1">MCSRVLPEALYNSFTRKISARVDPAIVRAVCVDHTKILAKVTIRRLPSEGELLTREEQAGFHNDHVHNIFTTEQNIMPRGTHQQRTIRLTVELMNPTDSFGVHFDERRSSQILKHPQSDIWCEFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNT8</accession>
    <name>A0A074ZNT8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167201.1">
        <property type="nucleotide sequence ID" value="XM_009168937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNT8"/>
    <dbReference type="GeneID" id="20318430"/>
    <dbReference type="KEGG" id="ovi:T265_04244"/>
    <dbReference type="CTD" id="20318430"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8145" checksum="886B7ADC4030CC77" modified="2014-10-01" version="1">MKISDNLLRENFVRRCESLSVRGNFMSSIFSLKVMVGKDGEGLAYFIEAESPRKRAEETAALEQQPPDDAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRZ7</accession>
    <name>A0A074ZRZ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">riboflavin kinase</fullName>
            <ecNumber evidence="2">2.7.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="2"/>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166140.1">
        <property type="nucleotide sequence ID" value="XM_009167876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRZ7"/>
    <dbReference type="STRING" id="6198.A0A074ZRZ7"/>
    <dbReference type="GeneID" id="20317594"/>
    <dbReference type="KEGG" id="ovi:T265_03407"/>
    <dbReference type="CTD" id="20317594"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="18245" checksum="0C52C4B96A5D3955" modified="2014-10-01" version="1">MLIELRNGAMFYAAGKVVHGFGRGSKQLGIPTANLDASVVARLPSTVANGIYFGWARVEGYPVCKTVVSIGWNPFFRNTTRSVEAHLIERFDEDFYDRVMHLLILKYHRPEKDFDNLDALVDCIHEDIRQANQYLDKPEATIWNHTNWFDLYTVPKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS39</accession>
    <name>A0A074ZS39_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL610108">
        <property type="protein sequence ID" value="KER18119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178134.1">
        <property type="nucleotide sequence ID" value="XM_009179870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS39"/>
    <dbReference type="GeneID" id="20330447"/>
    <dbReference type="KEGG" id="ovi:T265_16282"/>
    <dbReference type="CTD" id="20330447"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6649" checksum="62EA47FBDE4649D3" modified="2014-10-01" version="1" fragment="single">AFHHDHVGNSWESPDDRWSVRTAHYLCNRDCGNRDVDGEAVVPIGNQCHFSGTHPGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG7</accession>
    <name>A0A074ZTG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165500.1">
        <property type="nucleotide sequence ID" value="XM_009167236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG7"/>
    <dbReference type="GeneID" id="20317071"/>
    <dbReference type="KEGG" id="ovi:T265_02883"/>
    <dbReference type="CTD" id="20317071"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="521"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="744" mass="82309" checksum="44A7D3C1E9D5E826" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTQ4</accession>
    <name>A0A074ZTQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167109.1">
        <property type="nucleotide sequence ID" value="XM_009168845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTQ4"/>
    <dbReference type="GeneID" id="20318361"/>
    <dbReference type="KEGG" id="ovi:T265_04175"/>
    <dbReference type="CTD" id="20318361"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22156" checksum="C399EBAF6F8B1B2F" modified="2014-10-01" version="1">MKEDDQPPGTGNANKSSKQSLCSCGFSTFSRVDLNSFSCNTLSVSSCHSTRRKHEDWDTARLPKPRQGMSSGGGRIRTTDLPVNRSVVVPFRCLAVTHHEGGTRAGILPGRPSLDKRSREAEIGFEPQIFQSVKSRYNHLVQLAPLLVLTKADKIFMRSSSAVHTQCPCRGLNSGHLTFEASGVPLTSLKREHVHVKIWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTS6</accession>
    <name>A0A074ZTS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167052.1">
        <property type="nucleotide sequence ID" value="XM_009168788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTS6"/>
    <dbReference type="GeneID" id="20318316"/>
    <dbReference type="KEGG" id="ovi:T265_04130"/>
    <dbReference type="CTD" id="20318316"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="7177" checksum="112522F20BE6EA88" modified="2014-10-01" version="1">MEITCKTNQIQGRKSTTQHKREQTNQKRTNNTQMKLSKQPMECDIHIPLCSANRHRAKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTZ8</accession>
    <name>A0A074ZTZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165713.1">
        <property type="nucleotide sequence ID" value="XM_009167449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZTZ8"/>
    <dbReference type="GeneID" id="20317247"/>
    <dbReference type="KEGG" id="ovi:T265_03060"/>
    <dbReference type="CTD" id="20317247"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="9">
        <location>
            <begin position="315"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="467"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65691" checksum="3FBFA935E7729A51" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU08</accession>
    <name>A0A074ZU08_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166977.1">
        <property type="nucleotide sequence ID" value="XM_009168713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU08"/>
    <dbReference type="STRING" id="6198.A0A074ZU08"/>
    <dbReference type="GeneID" id="20327572"/>
    <dbReference type="KEGG" id="ovi:T265_13405"/>
    <dbReference type="CTD" id="20327572"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000491">
        <property type="entry name" value="zinc finger matrin-type protein 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="188" mass="22258" checksum="7EF719461E3B0ADC" modified="2014-10-01" version="1" fragment="single">NPVDHRRKWDRAHFEKLANDRLNNELEALRNARKEKDTVKKENLRARDYTIDLESNLNKSQVISKTGPGSSQAGYYCEVCDCVVKDSINYLDHINGKKHQRNMGMSMRIKRSTLEDVKDRFLLHKRRNEEKAEEYNLDERMRQIAEEEEKLRAYRSEKRREKKRKNEEPIDEDVAAVMGFGGFGKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUM7</accession>
    <name>A0A074ZUM7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166695.1">
        <property type="nucleotide sequence ID" value="XM_009168431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUM7"/>
    <dbReference type="GeneID" id="20318037"/>
    <dbReference type="KEGG" id="ovi:T265_03850"/>
    <dbReference type="CTD" id="20318037"/>
    <dbReference type="OrthoDB" id="10254713at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="368" mass="42865" checksum="A9FE2FC14A74C230" modified="2014-10-01" version="1">MTQSLFTPSECLALLAVFSDACKEVELLSNIGKHNFTSQNRSSGCAQTNQDTLLTELNKIFFQTLLRYEKSRREDYLELPDGTFRKLNEHESIKVKYLQIVSRVASTLRNLLIELDESGTFTTLEKYNNQEQSELDKLATFVGSAAEKEQELARLQEDVQALQMDIQKESVEFAATLRNLKHEFQEVREMAKMVLQYKSKEYTTALHEKMAAKTGNLRELTDKVERVKAVIAQSTRVSEETNCWLYSDITKKVMLSELIPQNDLPLKVSQRLEQIRKQLEDHKALHVKLQEDYETCDNILRVDQREKDAIRLREEYTKRVIMSVIQIQSWWRTMVAVRGIRLRRKRKGKKSAKYKKTTEEDKPTETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUR3</accession>
    <name>A0A074ZUR3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169087.1">
        <property type="nucleotide sequence ID" value="XM_009170823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUR3"/>
    <dbReference type="GeneID" id="20319925"/>
    <dbReference type="KEGG" id="ovi:T265_05743"/>
    <dbReference type="CTD" id="20319925"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15963" checksum="AFD37E7D1890043F" modified="2014-10-01" version="1">MNDELTTASLEMGEQKRSRLNMGLQKPVEIMLTDEWNVNLDRPSEEEIRYEIAALKREKAPIPDGLYPALFKEGGKSLVNHLTNLIDAIWDEEKVPAEWDMSTDIPIFKKNTPTLCDNHRGISLLAVTSKVLSGPEMGQING</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVA5</accession>
    <name>A0A074ZVA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TASOR pseudo-PARP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164792.1">
        <property type="nucleotide sequence ID" value="XM_009166528.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZVA5"/>
    <dbReference type="GeneID" id="20316502"/>
    <dbReference type="KEGG" id="ovi:T265_02314"/>
    <dbReference type="CTD" id="20316502"/>
    <dbReference type="OrthoDB" id="5960959at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046432">
        <property type="entry name" value="TASOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022188">
        <property type="entry name" value="TASOR_DUF3715"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16207:SF11">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12509">
        <property type="entry name" value="DUF3715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TASOR pseudo-PARP" evidence="2">
        <location>
            <begin position="103"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1390"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1515" mass="166995" checksum="868D1776DAAFC782" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVL7</accession>
    <name>A0A074ZVL7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597295">
        <property type="protein sequence ID" value="KER19189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177059.1">
        <property type="nucleotide sequence ID" value="XM_009178795.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZVL7"/>
    <dbReference type="GeneID" id="20326119"/>
    <dbReference type="KEGG" id="ovi:T265_11951"/>
    <dbReference type="CTD" id="20326119"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="175"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="533" mass="59907" checksum="C5E07DBE08AD3B09" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVW4</accession>
    <name>A0A074ZVW4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164952.1">
        <property type="nucleotide sequence ID" value="XM_009166688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVW4"/>
    <dbReference type="STRING" id="6198.A0A074ZVW4"/>
    <dbReference type="GeneID" id="20316627"/>
    <dbReference type="KEGG" id="ovi:T265_02439"/>
    <dbReference type="CTD" id="20316627"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="25930" checksum="7FF73DC571DED1BA" modified="2014-10-01" version="1">MQVNYARVCDRNSLSRSYNSNYRLVSTTANRRGLEEFFDDPKHWGETSVPAGRPWRKEELRLKSNSDLHRLWHILLKERNMLMTMDEEHYRCLERMPNPERFEKVEESMENIMYVVQERNQAEALLEDGEWIGPKTVHDVDVLGRPCVRLTSEHTEPRVADKRAQEDERMQGEKTIELLRLEREKQMRKRREHRRRECFSDRKRLWDQLDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW49</accession>
    <name>A0A074ZW49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164898.1">
        <property type="nucleotide sequence ID" value="XM_009166634.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZW49"/>
    <dbReference type="GeneID" id="20316589"/>
    <dbReference type="KEGG" id="ovi:T265_02401"/>
    <dbReference type="CTD" id="20316589"/>
    <dbReference type="OrthoDB" id="6255455at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1925"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2254" mass="250648" checksum="B8DF71496A0969F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW61</accession>
    <name>A0A074ZW61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597208">
        <property type="protein sequence ID" value="KER19439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176817.1">
        <property type="nucleotide sequence ID" value="XM_009178553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW61"/>
    <dbReference type="GeneID" id="20325959"/>
    <dbReference type="KEGG" id="ovi:T265_11791"/>
    <dbReference type="CTD" id="20325959"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="14795" checksum="65146C7FCD801727" modified="2014-10-01" version="1">MALLLLGGEQGHRQITDEYFVGLSFIHVARFRQTFRTMDAERKEAYAHSCLSEKRLQTLGEGSKTLICILLTKLNIRLHLERVFLNFAGYSFNVTQMQENATKPIYNSVIDFSFQKDANRSYAKTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWG3</accession>
    <name>A0A074ZWG3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164718.1">
        <property type="nucleotide sequence ID" value="XM_009166454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWG3"/>
    <dbReference type="STRING" id="6198.A0A074ZWG3"/>
    <dbReference type="GeneID" id="20316438"/>
    <dbReference type="KEGG" id="ovi:T265_02250"/>
    <dbReference type="CTD" id="20316438"/>
    <dbReference type="OrthoDB" id="6227380at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF136">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="445" mass="49248" checksum="9E2C44EFF5F25818" modified="2014-10-01" version="1">MMYANWKQFVGDPLMPKEWPRRARIGLNGFGQLARTLLRCALEDNRGLDVVAINEPNLTPEQMIYLFKYDTNLGPFAGYISERVEVAYAKEDQNGEYSNIQVAGRWIGVFHCKQPEDIPWNWLGVEYVLEMTGELRHLKEATKHLTGGRARKVLVVGDTVDIPLLMYPISCRGYQRGTSVVASGSPMAHAVATIVSLVDEICEMEDCMVTLVLPVGDCQNLIDGATKDARNWRMGRAAKQSIIPGRCPTVLQSVFQAIPKLNGRLNAITMHVPVFEGAVVDLTFRTMDVLNGVGDVVDRITKNSLLLQYNDLHIKTQPFRDKGSCFSQLKKASSSASSMADSVRRDSDQTLSQSSGPNVVAGTDINPTIQMPDGLTSVLMPVNKEDAYVSSDTTAKHTLCLLSVDCCFGIPAGNTFKLVTWFDLGVSYCERLLDTVVFMRSIDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWR4</accession>
    <name>A0A074ZWR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165878.1">
        <property type="nucleotide sequence ID" value="XM_009167614.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZWR4"/>
    <dbReference type="GeneID" id="20317382"/>
    <dbReference type="KEGG" id="ovi:T265_03195"/>
    <dbReference type="CTD" id="20317382"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ARID" evidence="7">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1344"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1346"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1393"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1573" mass="171947" checksum="BD65A0EF17181F7C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX21</accession>
    <name>A0A074ZX21_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164237.1">
        <property type="nucleotide sequence ID" value="XM_009165973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX21"/>
    <dbReference type="GeneID" id="20327039"/>
    <dbReference type="KEGG" id="ovi:T265_12871"/>
    <dbReference type="CTD" id="20327039"/>
    <dbReference type="OrthoDB" id="10404026at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704407" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16627" checksum="8D858A2FD2E948B3" modified="2014-10-01" version="1">MTLFNMKLGIFTLVLVIGCTVLIEATNVHNKCVARCWKKMPKCNNQCRTIKTPKQACKYFVARPKAPICSVNFTSTFHYATTDQLKIFMKSSCHEKPIKLCFENKRTHHCDRRFDGNIADCMLSKLNYRVSPNPSVLHIKSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXT7</accession>
    <name>A0A074ZXT7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sec23/Sec24 trunk domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_01675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164005.1">
        <property type="nucleotide sequence ID" value="XM_009165741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXT7"/>
    <dbReference type="STRING" id="6198.A0A074ZXT7"/>
    <dbReference type="GeneID" id="20315863"/>
    <dbReference type="KEGG" id="ovi:T265_01675"/>
    <dbReference type="CTD" id="20315863"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="10">
        <location>
            <begin position="385"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="654"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="139796" checksum="500A48F779EF1C59" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYQ5</accession>
    <name>A0A074ZYQ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_01286</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163556.1">
        <property type="nucleotide sequence ID" value="XM_009165292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYQ5"/>
    <dbReference type="STRING" id="6198.A0A074ZYQ5"/>
    <dbReference type="GeneID" id="20315474"/>
    <dbReference type="KEGG" id="ovi:T265_01286"/>
    <dbReference type="CTD" id="20315474"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="276"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1065"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KER32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128070" checksum="83794ADF9CBDFCC9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYZ6</accession>
    <name>A0A074ZYZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165044.1">
        <property type="nucleotide sequence ID" value="XM_009166780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYZ6"/>
    <dbReference type="GeneID" id="20316705"/>
    <dbReference type="KEGG" id="ovi:T265_02517"/>
    <dbReference type="CTD" id="20316705"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="14053" checksum="3D72777E05B6E167" modified="2014-10-01" version="1">MVFPNDFAHVAMLGTFAAGRDRGSTSEAAVCQCKLTRFTPIVVALLVRFETPTAYVQDFTQTPLAYYCLPDAIFWCNSRLRRRLLGTLRYSFICCFVAQLVCLVPNNHTWPTGTSRGLCSEESATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ02</accession>
    <name>A0A074ZZ02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Desmoplakin SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597059">
        <property type="protein sequence ID" value="KER20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175828.1">
        <property type="nucleotide sequence ID" value="XM_009177564.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZ02"/>
    <dbReference type="GeneID" id="20325192"/>
    <dbReference type="KEGG" id="ovi:T265_11024"/>
    <dbReference type="CTD" id="20325192"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Desmoplakin SH3" evidence="4">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1281"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1627"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3952"/>
            <end position="3988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4188"/>
            <end position="4210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4277"/>
            <end position="4298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4320"/>
            <end position="4349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3973"/>
            <end position="3988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="4189"/>
            <end position="4201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="4322"/>
            <end position="4331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="4349" mass="478528" checksum="A470AE91E86A6B08" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZF1</accession>
    <name>A0A074ZZF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597044">
        <property type="protein sequence ID" value="KER20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175705.1">
        <property type="nucleotide sequence ID" value="XM_009177441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZF1"/>
    <dbReference type="GeneID" id="20325093"/>
    <dbReference type="KEGG" id="ovi:T265_10925"/>
    <dbReference type="CTD" id="20325093"/>
    <dbReference type="OrthoDB" id="10658966at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="15756" checksum="F52BD401B6FE8A35" modified="2014-10-01" version="1">MKLQNVCIQLPVYSPGEYVRVPVLPVRIFVTAPSAGCKPSTNWSDSNWRRDTPSSVGKARSNNCCRPLKNTVGSDPGAILAALNCLIASWRSAGVSNYAEAAGMDTDRGKSFKSADQKWPFIGASMSIEAMFGRNHAALFKQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZU3</accession>
    <name>A0A074ZZU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163282.1">
        <property type="nucleotide sequence ID" value="XM_009165018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZU3"/>
    <dbReference type="STRING" id="6198.A0A074ZZU3"/>
    <dbReference type="GeneID" id="20315263"/>
    <dbReference type="KEGG" id="ovi:T265_01075"/>
    <dbReference type="CTD" id="20315263"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="38"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="29483" checksum="FCA358CE8EA52931" modified="2014-10-01" version="1">MDPKANIHGLLNGIENYNPEHKAILEQHLNWQASTGEYDFEANLALLRLYVSCSLNFIMDNRYQFYPELFNADATRLVLLKALASLNPTDFTICKYLIHLDRLNEEPLSLVVELGTLLESCQFPDFWVCCILLVQVLMLIQLRLRENPNITSGVPGFRDAMVKFIVQIVCQTYQRIHKSLLIRLLDMSEAELKQLIKQNGWTECPPSSPGDPNGPLVLVNKHEENVKSVKIQERVDFDAITSMSGAFRPAKGDFFIKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZX3</accession>
    <name>A0A074ZZX3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164663.1">
        <property type="nucleotide sequence ID" value="XM_009166399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZX3"/>
    <dbReference type="GeneID" id="20316399"/>
    <dbReference type="KEGG" id="ovi:T265_02211"/>
    <dbReference type="CTD" id="20316399"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18661" checksum="EE91091C97FA34AE" modified="2014-10-01" version="1">MSTGMTSIGKELYEQMANKLSFSLCCGAQPIEHHKELKQYQVCIIIPEGHRQVEYSDTTVVTSLSFGAVHSPKKPGFEYRELNPIPQIQKIAFSPKDSYEGINMTQHLSKRLDFRFMLKIIMNEGFSWVPGESPVKTESECKRLFYPLEEEQDVYITVMFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A025</accession>
    <name>A0A075A025_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163146.1">
        <property type="nucleotide sequence ID" value="XM_009164882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A025"/>
    <dbReference type="GeneID" id="20315155"/>
    <dbReference type="KEGG" id="ovi:T265_00967"/>
    <dbReference type="CTD" id="20315155"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="316"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="531" mass="62640" checksum="6C9CCF418B43DA02" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0A2</accession>
    <name>A0A075A0A2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164596.1">
        <property type="nucleotide sequence ID" value="XM_009166332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0A2"/>
    <dbReference type="GeneID" id="20316346"/>
    <dbReference type="KEGG" id="ovi:T265_02158"/>
    <dbReference type="CTD" id="20316346"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10118" checksum="69FC387703672999" modified="2014-10-01" version="1">MPQKPQKCRNNNRLTSSLKTTILARPILEENRIRSAVLLDSDGSFSPTTEWASEVICPNLLSGAKSEVANGYPPTSALQRRNFPQASFSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0G1</accession>
    <name>A0A075A0G1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597010">
        <property type="protein sequence ID" value="KER20914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175343.1">
        <property type="nucleotide sequence ID" value="XM_009177079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0G1"/>
    <dbReference type="STRING" id="6198.A0A075A0G1"/>
    <dbReference type="GeneID" id="20329384"/>
    <dbReference type="KEGG" id="ovi:T265_15219"/>
    <dbReference type="CTD" id="20329384"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER20914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="49435" checksum="7AE4EE129C1ADBE9" modified="2014-10-01" version="1">MSPRPIVPGIQTLKRKRAKRSNPQIILILNSSRSGYCLRISNDFVNICDVLLIWLLKIRRQPTIGFTLFGAHQAQSPGFRQPYVLPEAKLHETSEYTLICKLIWFFERLTWNPAEPLVCDVSRRLNVPHQAASCFSRYCIRDIALHVAENPENITNERFSWVPDICGVPESTSSLMRDTATMLCSKCEQPIREAHLLVADDKYWHEDCLRCACCDVRLAELDKVCYMKARMPLCRRDYLRLYGKTGICVVCLKRILGFEFVMRIQENVYHLNCFCCQRCQLRFCIGDKFYLQNKTILCEQDYIDSRMLSIQPNLCQETSEVLTFKTAVPTMCHTSTTQNIPPYGIEFGKKLPKTQPTIKTLSRQNDMKSTLQPRQRKKVASWKTHCGSHDQEAMKTRSVDNELKLNTSSDDHSSGYGSPSPSAVTPLERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1N2</accession>
    <name>A0A075A1N2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162587.1">
        <property type="nucleotide sequence ID" value="XM_009164323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1N2"/>
    <dbReference type="GeneID" id="20314707"/>
    <dbReference type="KEGG" id="ovi:T265_00519"/>
    <dbReference type="CTD" id="20314707"/>
    <dbReference type="OrthoDB" id="6085162at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="24345" checksum="0A09422449491F22" modified="2014-10-01" version="1">MAFHSTTQMKCELTSESNFLMRESPNLTPLYYWFWGMIGARVYHENKPKYLVGLRARIEHASARVTLEEVKHAVSHISYHPQLVIEERGDFFDIFCNAQFPSSRQPCVLLEPKLHEISEIGSFANKFGPSRDSPATQLNLSQAQSLGFRQQYVLIEPKLYKISEMHSFVNKFGVARDSPFVYNVLGFCATGVVKLLNTHFLAFWNSYFMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2E2</accession>
    <name>A0A075A2E2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174677.1">
        <property type="nucleotide sequence ID" value="XM_009176413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2E2"/>
    <dbReference type="STRING" id="6198.A0A075A2E2"/>
    <dbReference type="GeneID" id="20324302"/>
    <dbReference type="KEGG" id="ovi:T265_10134"/>
    <dbReference type="CTD" id="20324302"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="502" mass="54395" checksum="FAE0628DD34DCDBA" modified="2014-10-01" version="1">MFASSRFGAVFNAETGASVGVIMGVSKNINSVDFRPTRPYRAITGNDEGLVNYFEGPPFTFKHYFKHHTTFVNIVRFCPSGTCFVSGGADGKIFVYDAQAGSTIGEVGSPAHSGGVYGICFSTDGSRMLSGSADKTLKLWKVEGQEISALSTHQFPNDTSYMVLGCCWVGDTVVALTFNGFLHLFDAPTHVNSLSEPRMVIAGHQTLITCGVYNKKLQRLITASSDANMASWDLQAGLAEMFFGEHTHKAQVQSIALCDNYLVSVGLDDRCVLANITEKSFIASIKLPSQPHCVGVMPIQHIAVVACDKHICLLSASNRTLSMLDHQEISCGPCTITVSPQTETAIVCSASGQIMAYKTMDGKLHKTQVMNPPSPLPIMGSYSPDGSMLALVDADRTVTVHKVSDERDINHAPVLTPAHSEWWQRQTARITAIGWSPNGRRLATGSLDTSIAVWSVDSPKTTIYLRNAHPMSSSTSLCWTDDFTLVSTAMDGSIRCWTVKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2R9</accession>
    <name>A0A075A2R9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166351.1">
        <property type="nucleotide sequence ID" value="XM_009168087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2R9"/>
    <dbReference type="STRING" id="6198.A0A075A2R9"/>
    <dbReference type="GeneID" id="20317755"/>
    <dbReference type="KEGG" id="ovi:T265_03568"/>
    <dbReference type="CTD" id="20317755"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="361" mass="41740" checksum="2D8B35EADB2EB32F" modified="2014-10-01" version="1">MGQASTRMDFEWSYTEEPHASRRKEILSKYPEIKELMGPDPQLKWKVTFLVLFQIVTLFWVREFSWPTLLICAYLVGGVINHALNLAIHEISHNLAFGHSHPMLNRALGMFANLPIGVPVSISFKKYHILHHRYQGDRELDVDVPTEFEGRWFATTGMKFLWLILQPAFYSIRPLLLLPLPVTGLELINILVQVVFDGLVLYLFGWKALLYLFSGTLLAMGVHPVAGHFISEHFVFDEKFETYSYYGILNLLTLNVGYHVEHHDFPYIKTTSGMLLLVTRVRFFVVGLFAELGSWIAKVLSPIGMTLSLRKIASEYYENLPHHTSWVKVLYDFVMRPDIGPFARVCRRRRTNLANDDSYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Z9</accession>
    <name>A0A075A2Z9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162441.1">
        <property type="nucleotide sequence ID" value="XM_009164177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Z9"/>
    <dbReference type="GeneID" id="20314592"/>
    <dbReference type="KEGG" id="ovi:T265_00404"/>
    <dbReference type="CTD" id="20314592"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6766" checksum="746FC00142D6DBC5" modified="2014-10-01" version="1" fragment="single">AVAENSSTAWKHHKREIQLGSRETTHKVAENSSTAHDRFRPSWGSSGGRSPRVSVSLAFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3U3</accession>
    <name>A0A075A3U3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163319.1">
        <property type="nucleotide sequence ID" value="XM_009165055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3U3"/>
    <dbReference type="STRING" id="6198.A0A075A3U3"/>
    <dbReference type="GeneID" id="20326873"/>
    <dbReference type="KEGG" id="ovi:T265_12705"/>
    <dbReference type="CTD" id="20326873"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="408" mass="45494" checksum="C02B7DAA21756E7B" modified="2014-10-01" version="1" fragment="single">MTRGQQKIQAQQRNAKKQADLKKSTVDQKKAASKALIYQCTVCKTQMPDPKTYRQHFENKHPKNPLPEELKDVSVNLLTGRSVVRTLHLDFPSRLGQPGSIPAVELPSGGMAARDQKSATAERFLTTDVPEALLLLDDSNKFVTNGLENGHSVERDGSKREYTDRKVRGSNPTSASRLLLSRLEQSDSIPALVPPSGGMTARHRKGVTVERAGVRLCRRGFSRGEHPALSTTWARPYATHTETSVILHVSFRMTQIAPVFPPALGWRHCKKWRLIDVSGVRVVSFFQIVLLNIWRCRHLKMLAIGQHQVPFISSYHCCTAVRSAHSELAQCLEGEFTDRKVRGSNPISAPRVPLSRLGQPGSIPALELPSGGMVPRHREGPTSERFTPLRRCTAFIVFSDLALRRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3W0</accession>
    <name>A0A075A3W0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162205.1">
        <property type="nucleotide sequence ID" value="XM_009163941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3W0"/>
    <dbReference type="STRING" id="6198.A0A075A3W0"/>
    <dbReference type="GeneID" id="20314421"/>
    <dbReference type="KEGG" id="ovi:T265_00233"/>
    <dbReference type="CTD" id="20314421"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040247">
        <property type="entry name" value="DUF5524"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31097:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31097">
        <property type="entry name" value="SI:DKEY-276J7.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17662">
        <property type="entry name" value="DUF5524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="29065" checksum="E6A43587894390E3" modified="2014-10-01" version="1">MHTNLRDIGWMCHVVPLKKNKSPAFMPAISQIPILGCAPEDSNPKSEPVSNIKSTDTPFIRLAKMGGRPDLLCFKENEPNNGPPLPYCRCDWFYLEDNAKHDEDTKPPATKHVFKVPFYMTDQECKPKEQLTKPIVQSTPPVLPPRKPKKCGKLPPHRPGYADYNRKPSKIGIAYSPPVRKEPIRFPKRNVEECNPTTLPKVLANAYKSDYDEYRKQWQEVKNYYKDKDSCALKFEPPRPSKRSLGPKGNDVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A592</accession>
    <name>A0A075A592_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596890">
        <property type="protein sequence ID" value="KER22584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173668.1">
        <property type="nucleotide sequence ID" value="XM_009175404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A592"/>
    <dbReference type="GeneID" id="20328982"/>
    <dbReference type="KEGG" id="ovi:T265_14816"/>
    <dbReference type="CTD" id="20328982"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="32813" checksum="2EF707B8331F9F17" modified="2014-10-01" version="1" fragment="single">MPSTYPTSASESPGSTSNPQAVEAGSEFSMIVSVTKLKRKGERGQPCRTSLDVPRASRAACSELRILQRFRHPGLPPLVGYAYDVHSGSPDIIVLQLFTPHYSIGCLRNFLATQDSCSKLDAVQRLRILHTIASTLSFLHNNKPDEVCHGNICSRCIMLTKSMEPILFDFTNAYSPSRSSERKESPNPEGYHYASHLQCSGLFRDIYSFGVLSLEVWLNEEPMPGYWTDNHGSPVVSPGVSLAERVICSIGTKQTYPLKVSPFIYWTAEMHRNVLELVSPCLDIKQQNTANCLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A655</accession>
    <name>A0A075A655_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16149"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.12"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:16151"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162508.1">
        <property type="nucleotide sequence ID" value="XM_009164244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A655"/>
    <dbReference type="STRING" id="6198.A0A075A655"/>
    <dbReference type="GeneID" id="20314659"/>
    <dbReference type="KEGG" id="ovi:T265_00471"/>
    <dbReference type="CTD" id="20314659"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047280">
        <property type="term" value="F:nicotinamide phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01569">
        <property type="entry name" value="PBEF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041529">
        <property type="entry name" value="DUF5598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016471">
        <property type="entry name" value="Nicotinamide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43816:SF1">
        <property type="entry name" value="NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18127">
        <property type="entry name" value="NAMPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005943">
        <property type="entry name" value="NMPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinamide phosphoribosyltransferase N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="188"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="328"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="370"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>beta-nicotinamide D-ribonucleotide</name>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005943-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="515" mass="57087" checksum="78F38BB9682A79FC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6V9</accession>
    <name>A0A075A6V9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7083 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164786.1">
        <property type="nucleotide sequence ID" value="XM_009166522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6V9"/>
    <dbReference type="GeneID" id="20316496"/>
    <dbReference type="KEGG" id="ovi:T265_02308"/>
    <dbReference type="CTD" id="20316496"/>
    <dbReference type="OrthoDB" id="6270619at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7083" evidence="1">
        <location>
            <begin position="57"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="27439" checksum="36BFD921B3037AA8" modified="2014-10-01" version="1">MLGRNPRGSPPRILQQQQKQFEEAQLKLIESLTQKLHIQNGAVSTGESSVSSTDAAAASITEFTFDALSGHTFDSWFKRYEDMFKTDFSKFDDGWKVRLLLRKLGTPEHERFTNFILPKLPRDLSFDETVRTLSQIFGDQTSMFNIRYQCLKLAKKDDDDFITFAGVVNRECERFKLSSMTENQFKCLIFLSGLQSSHDADIRTRLLNRIEQDAEMTPFAPLVFVLTWTLAWEAQTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A735</accession>
    <name>A0A075A735_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164722.1">
        <property type="nucleotide sequence ID" value="XM_009166458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A735"/>
    <dbReference type="STRING" id="6198.A0A075A735"/>
    <dbReference type="GeneID" id="20316442"/>
    <dbReference type="KEGG" id="ovi:T265_02254"/>
    <dbReference type="CTD" id="20316442"/>
    <dbReference type="OrthoDB" id="6254748at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="301"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="442" mass="49699" checksum="AA7F25D4E4AF0080" modified="2014-10-01" version="1">MGNQESSTSEGEVAERDERKSQQRDGNNHESEEDEKPVLLQDNQTNNLEYLSYDDIYLEEDEDIVKLDEADEEESDEEMAPSIFPSSASSISHVPAFAARLIMGISYVQQQATLHIELGGTTEVPGRGQGGARAYQAMLVNVLNDDPVWLTSKMRSGPNPAFDDNWEVKLAKIQLPRTVIECQLYGCTNGQRERLCSEGSVSLSEINPRIKNQMIVRLHPRFVAASVRTAQSIDHETVDYDAWTEVTESSRYTKTMSDTSSETETMMTRPQSLVQQQPGRVQFTNENKVRETPTEVHRQPTSAEILLNASYNATTGKFECSIQKAHGLYRPGRSAKAPSCYVQITFSDNEGKEIAQGITQTVKRTTTPVFHEVLVFNVAQHLTGEVTMQLTVYHKQTTGKKQGIGLILMGKRNSSETEKEHWEEIIDGHGQRIARWHKLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A775</accession>
    <name>A0A075A775_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162123.1">
        <property type="nucleotide sequence ID" value="XM_009163859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A775"/>
    <dbReference type="GeneID" id="20326611"/>
    <dbReference type="KEGG" id="ovi:T265_12443"/>
    <dbReference type="CTD" id="20326611"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8414" checksum="DEDB84A4DBD95481" modified="2014-10-01" version="1" fragment="single">GYDIPQLSVLHKGRLSFHLARYSKYHSILSYRKLLTRLSGAAYRLISAILLLGGGKHLYRMFCVNRDQYWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7Y4</accession>
    <name>A0A075A7Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172680.1">
        <property type="nucleotide sequence ID" value="XM_009174416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7Y4"/>
    <dbReference type="STRING" id="6198.A0A075A7Y4"/>
    <dbReference type="GeneID" id="20322750"/>
    <dbReference type="KEGG" id="ovi:T265_08571"/>
    <dbReference type="CTD" id="20322750"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="397" mass="43652" checksum="C539B78FB5166B37" modified="2014-10-01" version="1">MVKGKFQDYLPTRGNSWTYSCLHCRAHLARHEDLISKSFQGSQGRAYLFNQVVNVEFSEAKQRVLLTGIHFVADVFCACCQTMLGWKYERAFEASQRYKEGKVIVELAHLIKDNGWDWDWINPPRRSQSAFSAHSSLSKPVGVTDDCPGFFQPSKTLGGGRLVATSVLPSHCHSAPQDNPFLQTVIPPRDGGAGTFATPISLSAFPSTSVQPPTASWGFGDRQYSTACDSARSDGSFGLDAVHFRTPEEGNSPACEIHIPAGAATAAAGSVSSIARPFQFAESSQSTKESDTQSPRRAAMELTDYRATSPTSHSSRLFPQIQLGGHKRRRRKRALFQRRASSSSPSRTSLLPLVSDEDSDEERAANFGRMNQLEFCLTPPPRLFSTLPHPKSFKDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9B4</accession>
    <name>A0A075A9B4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172130.1">
        <property type="nucleotide sequence ID" value="XM_009173866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9B4"/>
    <dbReference type="STRING" id="6198.A0A075A9B4"/>
    <dbReference type="GeneID" id="20322325"/>
    <dbReference type="KEGG" id="ovi:T265_08146"/>
    <dbReference type="CTD" id="20322325"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="59"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23056" checksum="78FA30B9D8FB9E08" modified="2014-10-01" version="1">MTLARWMFIGQLKRRRTLPALDVPDDAPDQKRSCQGIGPYASFLALCGMTAQPESKISRIVLFPIDGSTHCERAFAWYVDNLKAPNDHLVFFTVVEPVFPGHAFELAVEAYIMSNMAPVLDASITKSKRLCREKMQKAKELGLHAQAFLHVDSRPGHAVTEAIEDHNAAIVVMGSRGLGAFRRTVLGSVSGYVLHHSHVPVVIVPPETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA18</accession>
    <name>A0A075AA18_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_07913</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171837.1">
        <property type="nucleotide sequence ID" value="XM_009173573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA18"/>
    <dbReference type="STRING" id="6198.A0A075AA18"/>
    <dbReference type="GeneID" id="20322092"/>
    <dbReference type="KEGG" id="ovi:T265_07913"/>
    <dbReference type="CTD" id="20322092"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05034">
        <property type="entry name" value="PTKc_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11845">
        <property type="entry name" value="SH3_Src_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000399">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="372"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="514"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER24399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="839" mass="95223" checksum="42315689330183C5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC25</accession>
    <name>A0A075AC25_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171015.1">
        <property type="nucleotide sequence ID" value="XM_009172751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC25"/>
    <dbReference type="GeneID" id="20321452"/>
    <dbReference type="KEGG" id="ovi:T265_07273"/>
    <dbReference type="CTD" id="20321452"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="271" mass="29758" checksum="59794CB7D80E1966" modified="2014-10-01" version="1">MEDPCFGPNSGTSTAPIGAWALVLPSGGMAARHRKGVTAERLQLLPIVNLNQKQLFLFLSSNTTLHLTEIPSKFGLGSISCSRKASNWLGRSQVFYGYTVRSALWCGSALVGARWPKWLEREFTDRKALATWRYPNPRANFGLRVRGSNPTSASRLPLSRLGRTGSIPALLQPSGGRAARHRKDATVKRFSALVQLCGSGAWTGRSVVRTGPLSLDFPRLGLGNMAVSQPSCFLRVAWQLGTKRVLQLNKRQHTFELRNRSNNSSTPDNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEC1</accession>
    <name>A0A075AEC1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169651.1">
        <property type="nucleotide sequence ID" value="XM_009171387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEC1"/>
    <dbReference type="STRING" id="6198.A0A075AEC1"/>
    <dbReference type="GeneID" id="20320368"/>
    <dbReference type="KEGG" id="ovi:T265_06186"/>
    <dbReference type="CTD" id="20320368"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="458"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110733" checksum="CCB3F55B57BA2221" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGJ7</accession>
    <name>A0A075AGJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167490.1">
        <property type="nucleotide sequence ID" value="XM_009169226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGJ7"/>
    <dbReference type="GeneID" id="20318659"/>
    <dbReference type="KEGG" id="ovi:T265_04477"/>
    <dbReference type="CTD" id="20318659"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="208" mass="23079" checksum="BB2647B66B817299" modified="2014-10-01" version="1">MALFTPIKCSRKGHKEECCKDNFRSSRKHRPDKRRQAEAMTATFRMKAPGRLQLCIGPLASCSAHYDIPKGTVALHNRLWRQSKIITTAFIGINYRSSATPFPCLATKPPEGEMRAGIIPGFPALDKSNREAGFGFKLRTFWDYVSRNEITDQRVRGSNPTRSASRLPLSGLGQPGSIRAIILPSGGMEAGHRKGVTDERFPPAILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHD1</accession>
    <name>A0A075AHD1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Homeobox domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_03777</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166594.1">
        <property type="nucleotide sequence ID" value="XM_009168330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHD1"/>
    <dbReference type="STRING" id="6198.A0A075AHD1"/>
    <dbReference type="GeneID" id="20317964"/>
    <dbReference type="KEGG" id="ovi:T265_03777"/>
    <dbReference type="CTD" id="20317964"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER29674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62968" checksum="8BC0599747F1622B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHV9</accession>
    <name>A0A075AHV9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165696.1">
        <property type="nucleotide sequence ID" value="XM_009167432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHV9"/>
    <dbReference type="GeneID" id="20317230"/>
    <dbReference type="KEGG" id="ovi:T265_03043"/>
    <dbReference type="CTD" id="20317230"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="21146" checksum="3399605D506B6510" modified="2014-10-01" version="1">MLGINCVLPTEAHSWCLLLRSLKVFSRFELKASASQLCAEWKRPSSGQCMTWKRSMKTVTNKLRRAFNQKPGGHHFEFLWKFARWSKWLECEFTRREARVAWQLGTKRVLQLNDCFREIHIADNLRQTRKNHTMLLHYSALAMYHLAPPHQFQPVHKRDWWGSRVRNVASAANRKLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI66</accession>
    <name>A0A075AI66_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAYSvFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165097.1">
        <property type="nucleotide sequence ID" value="XM_009166833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI66"/>
    <dbReference type="GeneID" id="20316742"/>
    <dbReference type="KEGG" id="ovi:T265_02554"/>
    <dbReference type="CTD" id="20316742"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19075" checksum="292A5EB29E446085" modified="2014-10-01" version="1">MTPILFCLFLFFDSFYFLIFRIRLSTEADMSSYRKIKNELEAYRMNKTQNADINLVEQHKGICNVDLLQVNESITQGESTHEPNKPTSAIRQVLFSCKFQFIVTFLLWIAAVQIGFGAVWFVLAALYWIWVWGTNKSTRSHVPGESIVSAGFYFDTSPFPLHAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ8</accession>
    <name>A0A075AIJ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164542.1">
        <property type="nucleotide sequence ID" value="XM_009166278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIJ8"/>
    <dbReference type="GeneID" id="20316307"/>
    <dbReference type="KEGG" id="ovi:T265_02119"/>
    <dbReference type="CTD" id="20316307"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12418" checksum="6B75FD7D1CC6C865" modified="2014-10-01" version="1">MEPLSAESWTRQSIGYYLTVGKVQLPSMHCGSAVKVLEKAELTPRDVLTQHRIVNSFECLKRHHECSVEMRPPLFEPVYVDANNAQGDPETIDVLVNTRLTAKCAAKHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ32</accession>
    <name>A0A075AJ32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163629.1">
        <property type="nucleotide sequence ID" value="XM_009165365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ32"/>
    <dbReference type="GeneID" id="20315547"/>
    <dbReference type="KEGG" id="ovi:T265_01359"/>
    <dbReference type="CTD" id="20315547"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11234" checksum="D185A7F62EEFF60F" modified="2014-10-01" version="1">MDEKPRRTTDVSATKSKQIIACVTSGALSPPVVCNPQKCVHLYDSNKWLAPQSGQPRTTELLKDSDAVKCVRNDADKLTEGPLATLDLVFDSSDNTPEAYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG1</accession>
    <name>A0A075AJG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_12643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162989.1">
        <property type="nucleotide sequence ID" value="XM_009164725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJG1"/>
    <dbReference type="STRING" id="6198.A0A075AJG1"/>
    <dbReference type="GeneID" id="20326811"/>
    <dbReference type="KEGG" id="ovi:T265_12643"/>
    <dbReference type="CTD" id="20326811"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0041">Annexin</keyword>
    <keyword evidence="9 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="607" mass="67281" checksum="717C8BDC254039B1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG8</accession>
    <name>A0A075AJG8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162797.1">
        <property type="nucleotide sequence ID" value="XM_009164533.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJG8"/>
    <dbReference type="GeneID" id="20314872"/>
    <dbReference type="KEGG" id="ovi:T265_00684"/>
    <dbReference type="CTD" id="20314872"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1378"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1417" mass="153320" checksum="19CD4DB6F133918E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTY2</accession>
    <name>A0A074YTY2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL608409">
        <property type="protein sequence ID" value="KER18158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178095.1">
        <property type="nucleotide sequence ID" value="XM_009179831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTY2"/>
    <dbReference type="GeneID" id="20330419"/>
    <dbReference type="KEGG" id="ovi:T265_16254"/>
    <dbReference type="CTD" id="20330419"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="6989" checksum="09C60B582E55F6E6" modified="2014-10-01" version="1" fragment="single">MTSVESGAGRRSPPIRLSMGSLPIARTDSNSALCCGVPSSPGHGLPVTITSDHYLPPVVPHTFRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVC1</accession>
    <name>A0A074YVC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599101">
        <property type="protein sequence ID" value="KER18628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177625.1">
        <property type="nucleotide sequence ID" value="XM_009179361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVC1"/>
    <dbReference type="STRING" id="6198.A0A074YVC1"/>
    <dbReference type="GeneID" id="20330095"/>
    <dbReference type="KEGG" id="ovi:T265_15930"/>
    <dbReference type="CTD" id="20330095"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9543" checksum="E798CE6BB18CBB41" modified="2014-10-01" version="1" fragment="single">QQWEKQNPLLKKELFGVSKDVTDAANANRQPQHNLRAEGLLNGEGMTGNSLEVSGGSRQGSFRSSFRRHGANTHEPRSREIGQQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVK0</accession>
    <name>A0A074YVK0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598746">
        <property type="protein sequence ID" value="KER18678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177575.1">
        <property type="nucleotide sequence ID" value="XM_009179311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVK0"/>
    <dbReference type="GeneID" id="20326362"/>
    <dbReference type="KEGG" id="ovi:T265_12194"/>
    <dbReference type="CTD" id="20326362"/>
    <dbReference type="OrthoDB" id="10398664at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704767" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13675" checksum="8A598E061A4766B1" modified="2014-10-01" version="1">MPFQHDYLIPGSFILLILLLSERAHQFDGCKPVKGGHVMERKCKSGKFRWRVVENKMLKIHFLVMSATSVEDCKNICETFPQCGAFDRSVHEQTLKRDCNHCIKQTQIGGELDKHRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWZ5</accession>
    <name>A0A074YWZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597242">
        <property type="protein sequence ID" value="KER19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176923.1">
        <property type="nucleotide sequence ID" value="XM_009178659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWZ5"/>
    <dbReference type="GeneID" id="20329743"/>
    <dbReference type="KEGG" id="ovi:T265_15578"/>
    <dbReference type="CTD" id="20329743"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="3">
        <location>
            <begin position="196"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="32511" checksum="E214EC1ADFA9B16A" modified="2014-10-01" version="1" fragment="single">LYQPPNIISSKYFYLWAISSIREKINRGVHNQPSSRCHHVSKLPAAISKRFALDFYNWRSTKLFHSLEFSRISGKKNSQNEVSYGLFQLIYEKRPVATDCRHFIMQKFSEFNWRLMCFQLGDDYVNITNDTGSFGSWTGSENPPQIQSSATLLVALQTSDDGTLNPGYLANYSQKDRSENEVTRNESFYACCSTLSSGNVTSPGYPNAYPNRLRYSWIIVQPLGCVIQLNFSDFLGAESTTHRDLLSNSTFPQISCNKLKQEPYIQTKLNVTDAFVRARTQALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX21</accession>
    <name>A0A074YX21_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597235">
        <property type="protein sequence ID" value="KER19356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176895.1">
        <property type="nucleotide sequence ID" value="XM_009178631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX21"/>
    <dbReference type="GeneID" id="20326013"/>
    <dbReference type="KEGG" id="ovi:T265_11845"/>
    <dbReference type="CTD" id="20326013"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15951" checksum="135E4ACE83192FDE" modified="2014-10-01" version="1">MCFPRVAKTTLMNNIVITSLVGRYFKSGVSIKWQHLDTGFHQAISHKGISRTPEMAYRMWDTPAVGGILPMYLIWPISAESTPYVILVINKLFINSVKRIEIGPHPVVLHGSPEYTCRHVDSSKVVQHKCTWVPVYYHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZM5</accession>
    <name>A0A074YZM5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="12">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_15374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 12">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41733"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KL597078">
        <property type="protein sequence ID" value="KER20216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176043.1">
        <property type="nucleotide sequence ID" value="XM_009177779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZM5"/>
    <dbReference type="STRING" id="6198.A0A074YZM5"/>
    <dbReference type="GeneID" id="20329539"/>
    <dbReference type="KEGG" id="ovi:T265_15374"/>
    <dbReference type="CTD" id="20329539"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000149">
        <property type="entry name" value="Glycogen phosphorylase, muscle form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="845" mass="97709" checksum="C8E7893CA14F813D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0A8</accession>
    <name>A0A074Z0A8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175897.1">
        <property type="nucleotide sequence ID" value="XM_009177633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0A8"/>
    <dbReference type="GeneID" id="20325247"/>
    <dbReference type="KEGG" id="ovi:T265_11079"/>
    <dbReference type="CTD" id="20325247"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6911" checksum="8E801240A88296AA" modified="2014-10-01" version="1">MSPEGSTWAVILPDCPIPGRSSPDADVVFEPSGQRDRIISMELRNYPASTQIQNRRKVPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0L6</accession>
    <name>A0A074Z0L6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597040">
        <property type="protein sequence ID" value="KER20586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175657.1">
        <property type="nucleotide sequence ID" value="XM_009177393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0L6"/>
    <dbReference type="GeneID" id="20329447"/>
    <dbReference type="KEGG" id="ovi:T265_15282"/>
    <dbReference type="CTD" id="20329447"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="314" mass="33978" checksum="68BD846D7ECE34CD" modified="2014-10-01" version="1" fragment="single">RIQLLDESRFRNVCDTVLRQLYSAGSPFDANAEAVQTDYVDGLVDCFNDLAPLLTCTDRHAPCVCPFHEHVYTSVCRTLFELFCGTWYDCLQSRIQTLDTSQSGFPLLNRTARTCRLLIDSVLGRKSPLPVHLRRILHECDSFQQLRAYSSDSCEDLLYCFNTSCPSGCEISPPSSAPNSPTFSVVQPSFSPVPANLLGMPEARSPSDKTSTAPSCSTPDCTGDCSSVSSTSSSSSTAKRLRIKFANRLNAPTDTIAALAAGVRTSFMTSFKTLSAVGESKLTSSNLFIHSSTSPLATRSPSPSPDHNSAATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Z0</accession>
    <name>A0A074Z0Z0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597031">
        <property type="protein sequence ID" value="KER20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175569.1">
        <property type="nucleotide sequence ID" value="XM_009177305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Z0"/>
    <dbReference type="STRING" id="6198.A0A074Z0Z0"/>
    <dbReference type="GeneID" id="20324994"/>
    <dbReference type="KEGG" id="ovi:T265_10826"/>
    <dbReference type="CTD" id="20324994"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704871" description="SMB domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="5">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="46018" checksum="814D46D3239DEE66" modified="2014-10-01" version="1">MYWLIAAAILLLGDRSLLEVQASCKTGSGMAMCCRGRQPSCCSYTYDNGGNYSSRYQYCRYSPGTVFSLRSDLRTCFCDEHCTLTNDCCPDYRELCHKPAIDCTVSNWGPWSECNHQCGAGVRIRRRRVTHPAVNGGRHCPVLEETMPCQGTKCISRRVGRSGTLMIPFMNQVRSEVAHLLPMRSDVLRLTRRWDMRFDERRKLYLGRLIQQNKTEEPEPDPYCAVYEITHTNPACQMHNILWHYNRPSRLYDQRPNDYAWGRRNQGWPSRNGRTPEDIYTFNRNPYMPAAHRRVRRSTRSSRFGNDDPAEFGTSEDWRQAWTTHSALLQQGQQICVTCYPSYMREELGFRCSGTGLLNIETRWRALRTADCHGKFRMLSIPQRACTCGRGTGSFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z156</accession>
    <name>A0A074Z156_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597022">
        <property type="protein sequence ID" value="KER20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175476.1">
        <property type="nucleotide sequence ID" value="XM_009177212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z156"/>
    <dbReference type="STRING" id="6198.A0A074Z156"/>
    <dbReference type="GeneID" id="20324914"/>
    <dbReference type="KEGG" id="ovi:T265_10746"/>
    <dbReference type="CTD" id="20324914"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="242" mass="27518" checksum="D89FF80E79155DC9" modified="2014-10-01" version="1">MFLFAGVPSMAESAEERQSELEALSSIYEHNLHLIRDNGLQKFEVHLTGHGGGSDVSTECTITFEYTEEYPSQAPLYEISKCVNLSEHECAQIEELIESAIQRCLGYIMIFDVLSEVQEKINSICENRLAMRVKAEEAREKARELEEEAKFRGDRVTVESFLEWNAKFLAEMAALKEKNKAADETGQKRLTGREMFLRDNRYDDSDLKFLAENGEQVAIDESLFADIDLTDDLVLEDPTVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z201</accession>
    <name>A0A074Z201_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597189">
        <property type="protein sequence ID" value="KER19522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176733.1">
        <property type="nucleotide sequence ID" value="XM_009178469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z201"/>
    <dbReference type="STRING" id="6198.A0A074Z201"/>
    <dbReference type="GeneID" id="20325899"/>
    <dbReference type="KEGG" id="ovi:T265_11731"/>
    <dbReference type="CTD" id="20325899"/>
    <dbReference type="OrthoDB" id="6251518at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="570" mass="64290" checksum="774299899DF1E90F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z282</accession>
    <name>A0A074Z282_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597169">
        <property type="protein sequence ID" value="KER19612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176647.1">
        <property type="nucleotide sequence ID" value="XM_009178383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z282"/>
    <dbReference type="STRING" id="6198.A0A074Z282"/>
    <dbReference type="GeneID" id="20325837"/>
    <dbReference type="KEGG" id="ovi:T265_11669"/>
    <dbReference type="CTD" id="20325837"/>
    <dbReference type="OrthoDB" id="6271476at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="222" mass="25022" checksum="2580ED6F3167A774" modified="2014-10-01" version="1">MPPPKDVPSLRSFLGLISYYSQMPPPNDVPSLRTFLFLINYCSAFHPALHDIRPPLNQLLGKDVPWCWSEECEEPFCKLKTMLTSDILLTHYGPKLSIIVAADASNCGVGVVILHVFPDGSEKALKSLTPAKQRYGQIEEEALALVFAVRRFPKMLCGRRFTPLTDHKPLPSFFGSKKDVPAHSANRLQRWALVMLGYDFDIQYRRTTDFGQADALSRLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2E0</accession>
    <name>A0A074Z2E0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596984">
        <property type="protein sequence ID" value="KER21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175051.1">
        <property type="nucleotide sequence ID" value="XM_009176787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2E0"/>
    <dbReference type="GeneID" id="20324587"/>
    <dbReference type="KEGG" id="ovi:T265_10419"/>
    <dbReference type="CTD" id="20324587"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14193" checksum="904C4C5601DB4536" modified="2014-10-01" version="1">MHKPSSQEIRALNTEPSRLAATPPRRTTRPEIIPDFSSLNGRYSRSRGEATHKFADNSSIAHDRFCPSWISSGSVNQRFDLNPNCTEFDSYPHLHTDLVLKGNSPACFLDANYPFSPRVNICSALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3N4</accession>
    <name>A0A074Z3N4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596952">
        <property type="protein sequence ID" value="KER21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174619.1">
        <property type="nucleotide sequence ID" value="XM_009176355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3N4"/>
    <dbReference type="STRING" id="6198.A0A074Z3N4"/>
    <dbReference type="GeneID" id="20324255"/>
    <dbReference type="KEGG" id="ovi:T265_10087"/>
    <dbReference type="CTD" id="20324255"/>
    <dbReference type="OrthoDB" id="6280626at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="181" mass="20133" checksum="3D371C1CF2ABDA5A" modified="2014-10-01" version="1">MDAKLSDPKLIMDHVPFERRPRPGAESEEPGKRGRKRLGNPKLLITRLKVYPINWGYADGITEDENIHLYDSLPCTLLHGASWLSRNRSSVDLCVEAPLALLEVDILRSDGSDQSDLVLLSSRSHTDLVLNFNDRAYKCFNQPIEQSVASGTTFASTVANAKAPLVRDANLSAVKCWWKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z405</accession>
    <name>A0A074Z405_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL614549">
        <property type="protein sequence ID" value="KER18050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178203.1">
        <property type="nucleotide sequence ID" value="XM_009179939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z405"/>
    <dbReference type="GeneID" id="20330495"/>
    <dbReference type="KEGG" id="ovi:T265_16330"/>
    <dbReference type="CTD" id="20330495"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="42" mass="4366" checksum="1609832ADB85FC6C" modified="2014-10-01" version="1" fragment="single">FSEQGGDLDSIVYLNHTVDTPKYQANNGVASGVLSPDGSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z497</accession>
    <name>A0A074Z497_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597066">
        <property type="protein sequence ID" value="KER20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175919.1">
        <property type="nucleotide sequence ID" value="XM_009177655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z497"/>
    <dbReference type="GeneID" id="20325260"/>
    <dbReference type="KEGG" id="ovi:T265_11092"/>
    <dbReference type="CTD" id="20325260"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9437" checksum="74DEDB840404DCCA" modified="2014-10-01" version="1">MSAVKEQPYHEIYSDFLCSPVEVNQIPSYRYFNPQDAVYVDSNQINWQLRNTQRTGLPSELNILGSCDLLAGSLNMQSSSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z591</accession>
    <name>A0A074Z591_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596907">
        <property type="protein sequence ID" value="KER22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173950.1">
        <property type="nucleotide sequence ID" value="XM_009175686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z591"/>
    <dbReference type="STRING" id="6198.A0A074Z591"/>
    <dbReference type="GeneID" id="20323745"/>
    <dbReference type="KEGG" id="ovi:T265_09576"/>
    <dbReference type="CTD" id="20323745"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="11931" checksum="F940721AE6CF9FC2" modified="2014-10-01" version="1">MSTPVLVGLGILTVGLVGRYVTRQIKASQVPNLLKLSGFTTSKYYRGGFEPKMTRREAALILGVSQQSSKTKIREAHKRIMLLNHPDRGGSPYLAAKINEAKEFLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z625</accession>
    <name>A0A074Z625_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598781">
        <property type="protein sequence ID" value="KER18675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177578.1">
        <property type="nucleotide sequence ID" value="XM_009179314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z625"/>
    <dbReference type="STRING" id="6198.A0A074Z625"/>
    <dbReference type="GeneID" id="20330064"/>
    <dbReference type="KEGG" id="ovi:T265_15899"/>
    <dbReference type="CTD" id="20330064"/>
    <dbReference type="OrthoDB" id="66418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="12364" checksum="A6EDDC48EF50A173" modified="2014-10-01" version="1" fragment="single">ALANPTPPESSKPTADGDEPNDSATNPTSAVPINGLNAGETVEPNPAESPSTKPTADQIAKAKAAYNKAKLLHATYLALSGRAAEAKQQFQSVFAEGSGADTVVRVNALIKSACLSMSVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7B8</accession>
    <name>A0A074Z7B8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597334">
        <property type="protein sequence ID" value="KER19100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177153.1">
        <property type="nucleotide sequence ID" value="XM_009178889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7B8"/>
    <dbReference type="GeneID" id="20326175"/>
    <dbReference type="KEGG" id="ovi:T265_12007"/>
    <dbReference type="CTD" id="20326175"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="11768" checksum="E59CAB83DBEEA1E4" modified="2014-10-01" version="1">MRTLLDDLDYIASASGLETNRAKFTALEALFGGLGRPLWMGPNGYSEDGISLHIRSSWGGVRYTYLLPGVYETVYISQDISETQPISKDPEKVGAAIHDLPKTGDGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7V5</accession>
    <name>A0A074Z7V5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173098.1">
        <property type="nucleotide sequence ID" value="XM_009174834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7V5"/>
    <dbReference type="GeneID" id="20328862"/>
    <dbReference type="KEGG" id="ovi:T265_14696"/>
    <dbReference type="CTD" id="20328862"/>
    <dbReference type="OrthoDB" id="6247150at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043793">
        <property type="entry name" value="DUF5735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19006">
        <property type="entry name" value="DUF5735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705353" description="DUF5735 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5735" evidence="3">
        <location>
            <begin position="64"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117069" checksum="F63FB68B8D53680F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8S5</accession>
    <name>A0A074Z8S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597166">
        <property type="protein sequence ID" value="KER19620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176632.1">
        <property type="nucleotide sequence ID" value="XM_009178368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8S5"/>
    <dbReference type="GeneID" id="20325825"/>
    <dbReference type="KEGG" id="ovi:T265_11657"/>
    <dbReference type="CTD" id="20325825"/>
    <dbReference type="OrthoDB" id="9971251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10531" checksum="A1F2285BE94A8530" modified="2014-10-01" version="1">MCCIHQAASCCNRYDIRDITIHPEGVLRFKSKVPQSSCGKGRILPVINKHNFERYTHLQINLVFTTDSTESLVYDIPQLKVLHTGRSLGSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z916</accession>
    <name>A0A074Z916_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172568.1">
        <property type="nucleotide sequence ID" value="XM_009174304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z916"/>
    <dbReference type="GeneID" id="20322669"/>
    <dbReference type="KEGG" id="ovi:T265_08490"/>
    <dbReference type="CTD" id="20322669"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12678" checksum="2DD7ADE9074D4A76" modified="2014-10-01" version="1">MRSNKSGTRVQCFPLVWTPRNNYARTGTRPFKREWRGYEQKYLSRKTPKLHRKLSGYIANPVTGIDLAGDGAETVLKQVLHLVVVGLFAELGNLIANVSSPIDVTSLVRYCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z928</accession>
    <name>A0A074Z928_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174168.1">
        <property type="nucleotide sequence ID" value="XM_009175904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z928"/>
    <dbReference type="STRING" id="6198.A0A074Z928"/>
    <dbReference type="GeneID" id="20323907"/>
    <dbReference type="KEGG" id="ovi:T265_09739"/>
    <dbReference type="CTD" id="20323907"/>
    <dbReference type="OrthoDB" id="6283029at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="13748" checksum="2FE9C8FC12A57694" modified="2014-10-01" version="1">MKKLQGYGIGGDLVRWLKLFLHDRRSKVRVTDHCTDWYTSPSGVPQGTVLGPLLFLLIIIIIIIIIINNNSMTSRLCECRGTLSSIAQWVAEVRKPSHHGYIADDGKVTAAAHLATTRKMKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z950</accession>
    <name>A0A074Z950_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_14579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172535.1">
        <property type="nucleotide sequence ID" value="XM_009174271.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z950"/>
    <dbReference type="MEROPS" id="M14.016"/>
    <dbReference type="GeneID" id="20328745"/>
    <dbReference type="KEGG" id="ovi:T265_14579"/>
    <dbReference type="CTD" id="20328745"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1605"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1651" mass="184020" checksum="7983A11CC4384BF1" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA96</accession>
    <name>A0A074ZA96_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172079.1">
        <property type="nucleotide sequence ID" value="XM_009173815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA96"/>
    <dbReference type="STRING" id="6198.A0A074ZA96"/>
    <dbReference type="GeneID" id="20322287"/>
    <dbReference type="KEGG" id="ovi:T265_08108"/>
    <dbReference type="CTD" id="20322287"/>
    <dbReference type="OrthoDB" id="10048028at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005035">
        <property type="term" value="F:death receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048406">
        <property type="term" value="F:nerve growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13416">
        <property type="entry name" value="TNFRSF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052302">
        <property type="entry name" value="Neurotrophin_rcpt-DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034046">
        <property type="entry name" value="TNFRSF16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605:SF2">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46605">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704028" description="TNFR-Cys domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="5">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="576" mass="63198" checksum="376D298F74A031C0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBE0</accession>
    <name>A0A074ZBE0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Double zinc ribbon and ankyrin repeat-containing protein 1</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_09103</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="KL596874">
        <property type="protein sequence ID" value="KER22897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173355.1">
        <property type="nucleotide sequence ID" value="XM_009175091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20323282"/>
    <dbReference type="KEGG" id="ovi:T265_09103"/>
    <dbReference type="CTD" id="20323282"/>
    <dbReference type="OrthoDB" id="10033229at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052481">
        <property type="entry name" value="DZAN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003977">
        <property type="entry name" value="Parkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041170">
        <property type="entry name" value="Znf-RING_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16058">
        <property type="entry name" value="DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16058:SF4">
        <property type="entry name" value="DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17978">
        <property type="entry name" value="zf-RING_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01475">
        <property type="entry name" value="PARKIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
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            <begin position="1"/>
            <end position="68"/>
        </location>
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            <begin position="158"/>
            <end position="417"/>
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            <begin position="1264"/>
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        </location>
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            <begin position="1298"/>
            <end position="1332"/>
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            <begin position="544"/>
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            <begin position="1180"/>
            <end position="1216"/>
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            <begin position="544"/>
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        <location>
            <begin position="565"/>
            <end position="586"/>
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            <end position="1143"/>
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            <end position="1203"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="1204"/>
            <end position="1214"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER22897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1382" mass="152353" checksum="D28529FBE2A3DCF3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBL0</accession>
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        <recommendedName>
            <fullName evidence="12">Transient receptor ion channel domain-containing protein</fullName>
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        <name evidence="13" type="ORF">T265_09033</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
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                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        </location>
    </feature>
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        </location>
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        <location>
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            <end position="1355"/>
        </location>
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        <location>
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            <end position="1367"/>
        </location>
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        <location>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER22992.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1484" mass="166644" checksum="5D37D7D152130070" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="9">Palmitoyltransferase DHHC domain-containing protein</fullName>
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        <name evidence="10" type="ORF">T265_07654</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="113"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122495" checksum="E43F95F5CAC4F994" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD59</accession>
    <name>A0A074ZD59_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171071.1">
        <property type="nucleotide sequence ID" value="XM_009172807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD59"/>
    <dbReference type="GeneID" id="20328423"/>
    <dbReference type="KEGG" id="ovi:T265_14257"/>
    <dbReference type="CTD" id="20328423"/>
    <dbReference type="OrthoDB" id="6240202at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="678" mass="78001" checksum="7FC755E9F4DB1064" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEJ0</accession>
    <name>A0A074ZEJ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEJ0"/>
    <dbReference type="GeneID" id="20321130"/>
    <dbReference type="KEGG" id="ovi:T265_06951"/>
    <dbReference type="CTD" id="20321130"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="23549" checksum="E1CE2CD9E2455067" modified="2014-10-01" version="1">MSQGVNATFNSSHKHRDLVPPVRRSANSSTECKSTDLAKNIRLCSKGADRKASCVSLLHRTDFSGQITYQGKCLSQSPHWILYTTLVLNIGFNHPFGFGTNDRLPPVLKHICGVRQELVLPSFSGPLNVRKNNLETGRVADPDVRRFHQNRLPESLSNNLPSNVNSYWDEITTSVQCWECCQWYGTTMRTQALNIMPNLLKSPRDIPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEJ5</accession>
    <name>A0A074ZEJ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170569.1">
        <property type="nucleotide sequence ID" value="XM_009172305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEJ5"/>
    <dbReference type="STRING" id="6198.A0A074ZEJ5"/>
    <dbReference type="GeneID" id="20321086"/>
    <dbReference type="KEGG" id="ovi:T265_06907"/>
    <dbReference type="CTD" id="20321086"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042840">
        <property type="entry name" value="LMNTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47012:SF3">
        <property type="entry name" value="LAMIN TAIL DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47012">
        <property type="entry name" value="LAMIN TAIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="17806" checksum="F0AB48C8B8EC9A0A" modified="2014-10-01" version="1">MARGFYRTSVALQISEINPQGRFVKIYNADNEEYDLSACKLMQTIDGDLLNEYEFDQLIYLPAKTSIILWTNDIYNELSQQNHSASIRCPDVLCWGSGPNCTTSLYSPSGQLLAQLCGVNETKDDCVVRLSKMSSEECSCIPIGLPTTIPSGKRFKSACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEW5</accession>
    <name>A0A074ZEW5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596764">
        <property type="protein sequence ID" value="KER25841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170377.1">
        <property type="nucleotide sequence ID" value="XM_009172113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEW5"/>
    <dbReference type="STRING" id="6198.A0A074ZEW5"/>
    <dbReference type="GeneID" id="20320939"/>
    <dbReference type="KEGG" id="ovi:T265_06760"/>
    <dbReference type="CTD" id="20320939"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="188" mass="20783" checksum="B0CFC2F2BD8192F3" modified="2014-10-01" version="1">MTELSAEVSARISVARMNFANLHHLTFLGIDDESCVRTASGLLVPVSFTCFNPRCNPTAAADKLIKIWNAYDGNFEKSISGHKLGISDVSWSYDSRFLCSSSDDKTLKLWDLGTGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSVRLCCAAFTLYNVQFDESVKLWDVKTGRCIRTLPAHSDPVTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEX3</accession>
    <name>A0A074ZEX3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RhoGAP domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172076.1">
        <property type="nucleotide sequence ID" value="XM_009173812.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZEX3"/>
    <dbReference type="GeneID" id="20322284"/>
    <dbReference type="KEGG" id="ovi:T265_08105"/>
    <dbReference type="CTD" id="20322284"/>
    <dbReference type="OrthoDB" id="6281275at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1127"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1628" mass="176528" checksum="74F98C43BF553B70" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF19</accession>
    <name>A0A074ZF19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596938">
        <property type="protein sequence ID" value="KER21825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174433.1">
        <property type="nucleotide sequence ID" value="XM_009176169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF19"/>
    <dbReference type="GeneID" id="20324109"/>
    <dbReference type="KEGG" id="ovi:T265_09941"/>
    <dbReference type="CTD" id="20324109"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11761" checksum="1930B505F2CFECEA" modified="2014-10-01" version="1">MEHKGSNFLLKWIKFVPHVKLFFNNRPAVTPFRSLAAMPPEASTRAEILPGCPNLDKKSREAEVGFKPLEPTFPRSLTIRGSRHIPTAVKSRWASVRKRVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFZ2</accession>
    <name>A0A074ZFZ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170101.1">
        <property type="nucleotide sequence ID" value="XM_009171837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFZ2"/>
    <dbReference type="GeneID" id="20320720"/>
    <dbReference type="KEGG" id="ovi:T265_06541"/>
    <dbReference type="CTD" id="20320720"/>
    <dbReference type="OrthoDB" id="10651077at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="301" mass="34255" checksum="F32F60377DB1BB93" modified="2014-10-01" version="1">METLHIWLPTDVSGVLVVSFYPDRLSFSRLVPWREYANKFRTVRQFIVKKSFSCSALLVPSCHATTQRKHEAGIQSVCPNLDRGSREAEVEFEPRTFRFTDSCAFVHQLFKLPPPVLSYPPRPPKSLVNKTVAATTSHDISVQHRCFTVVKSRKPQCEEKNKSGEGRDIVLAYHNHSEVPTPPGTHSGNKIAAGIDEQPYLAVSVDQLSPSAMENFSLFGKRRFTMDNAWVNQRSFWRWTHCSMEVPFEEANKCFQNVSLRIRQHWNVPVLRQGGRKSEEISVLPPEGTASHSHTTKQLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG91</accession>
    <name>A0A074ZG91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173980.1">
        <property type="nucleotide sequence ID" value="XM_009175716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG91"/>
    <dbReference type="STRING" id="6198.A0A074ZG91"/>
    <dbReference type="GeneID" id="20323769"/>
    <dbReference type="KEGG" id="ovi:T265_09601"/>
    <dbReference type="CTD" id="20323769"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27969" checksum="DA5221E5E6C78920" modified="2014-10-01" version="1">MVDEEVQALVIDNGSGMCKAGFAGDDSPRAVFPSIVGRPKHKGVMVGMGQKDCYFGDEAQSKRGILALKYPIEHGIVTNWDDMEKIWHHTFYNQLRVPPEEHPILLTEAPLNLKANREMTQIVFETFNAPAMYVAIQAVLSLYGSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIIRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLTYVALNFDQEMSTAASSTVLERTYELPDGQLDHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHM7</accession>
    <name>A0A074ZHM7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171010.1">
        <property type="nucleotide sequence ID" value="XM_009172746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHM7"/>
    <dbReference type="GeneID" id="20321447"/>
    <dbReference type="KEGG" id="ovi:T265_07268"/>
    <dbReference type="CTD" id="20321447"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="15881" checksum="93955C96929F3F2E" modified="2014-10-01" version="1">MKLNLTFTLENYDRHVTNIHIALDVPERIANDDDGRGRVNLGVSGSNPTSASRLPLSGLGQLGSIQALVVPLGGMAVRDRKGATAERFFSWKRFRGEKYLVSLRLPNLKNEHAFTSKAWLYVSLSCFPVIETVAAGTNVPMAHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJZ1</accession>
    <name>A0A074ZJZ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168882.1">
        <property type="nucleotide sequence ID" value="XM_009170618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJZ1"/>
    <dbReference type="STRING" id="6198.A0A074ZJZ1"/>
    <dbReference type="GeneID" id="20327973"/>
    <dbReference type="KEGG" id="ovi:T265_13806"/>
    <dbReference type="CTD" id="20327973"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF27">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 71E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="718" mass="80173" checksum="1D0B81E249FA83F8" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKJ7</accession>
    <name>A0A074ZKJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169963.1">
        <property type="nucleotide sequence ID" value="XM_009171699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKJ7"/>
    <dbReference type="GeneID" id="20328195"/>
    <dbReference type="KEGG" id="ovi:T265_14029"/>
    <dbReference type="CTD" id="20328195"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14081" checksum="0EB55690AC31CA75" modified="2014-10-01" version="1" fragment="single">MSPRLVMKRLQPNCPAQQTSQRPSWRTVPQLTVWEDEDISVWDCITNSQSSFCNCRSEIGSVLYSIFPSSGDRNCGGNLLLTQPTYPLNPALTMSPRLVINVCVTSIGDETFAIQLSSSANRPTTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU5</accession>
    <name>A0A074ZLU5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167899.1">
        <property type="nucleotide sequence ID" value="XM_009169635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU5"/>
    <dbReference type="GeneID" id="20318979"/>
    <dbReference type="KEGG" id="ovi:T265_04797"/>
    <dbReference type="CTD" id="20318979"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9576" checksum="8728859AD013E483" modified="2014-10-01" version="1">MAEIKQQNKTNNSSLDGRDKPIIAPAQVEDCSENGDANRKPHCDVVNWWWYVSYDDAYTNASVLTITMRRKVKTLGETTWKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMA3</accession>
    <name>A0A074ZMA3_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMA3"/>
    <dbReference type="GeneID" id="20318841"/>
    <dbReference type="KEGG" id="ovi:T265_04659"/>
    <dbReference type="CTD" id="20318841"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7836" checksum="DCBCD24BE42D90D9" modified="2014-10-01" version="1">MCRYQGPQVTAYSTMHNQELLAEENMDPCRVLDAIESWPPITMETYCYASELEQTTGQTEWTDGINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNP0</accession>
    <name>A0A074ZNP0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009169003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNP0"/>
    <dbReference type="GeneID" id="20318486"/>
    <dbReference type="KEGG" id="ovi:T265_04304"/>
    <dbReference type="CTD" id="20318486"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9490" checksum="171E91A66995CD4E" modified="2014-10-01" version="1">MNDPKYIGTIAKINSTEEDKTIPLSGMFSAVAFKVALTTVLAFKGSITATTQSGVQIGRARVDEPSVGRPHSQFNLRSVGLQELPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPY1</accession>
    <name>A0A074ZPY1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Complexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Positively regulates a late step in synaptic vesicle exocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER25385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170899.1">
        <property type="nucleotide sequence ID" value="XM_009172635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPY1"/>
    <dbReference type="GeneID" id="20321363"/>
    <dbReference type="KEGG" id="ovi:T265_07184"/>
    <dbReference type="CTD" id="20321363"/>
    <dbReference type="OrthoDB" id="6229630at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22808">
        <property type="entry name" value="Complexin_NTD_CPLX_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF4">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16029" checksum="4EA29DA5A0D2B27B" modified="2014-10-01" version="1">MANYIAKSLVSKPLDAVKNVTKDVTTKQACEEELEAQLAAAEEKRREKFENMEEEREVLRQTIRDKYGIKKKDFLDVADISTRRRSSASSQRPSDASLSAPKRTPNEDSLPVNLPPILRDAANKAAALPQKIISEANEKCELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQX5</accession>
    <name>A0A074ZQX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166411.1">
        <property type="nucleotide sequence ID" value="XM_009168147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQX5"/>
    <dbReference type="GeneID" id="20317799"/>
    <dbReference type="KEGG" id="ovi:T265_03612"/>
    <dbReference type="CTD" id="20317799"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9795" checksum="FBAC084D8E298902" modified="2014-10-01" version="1">MTTTSEVRFLLGIPKEQLPEKQQRTGTSKIKKAKKIVGNSPGLPEGSNPHKFLPKSKRDWPQDQEAVPWKCLSELGIVIRRDPVFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR66</accession>
    <name>A0A074ZR66_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167966.1">
        <property type="nucleotide sequence ID" value="XM_009169702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR66"/>
    <dbReference type="GeneID" id="20327782"/>
    <dbReference type="KEGG" id="ovi:T265_13615"/>
    <dbReference type="CTD" id="20327782"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="403" mass="44689" checksum="20E05453F5A31A81" modified="2014-10-01" version="1" fragment="single">MTICPDVNGASVFVATDTLGACEDCRCDDSFGTIFEISQYIFMKETTHKVAENSSTAHDRFLHFWDSSGRHSPRRLKHEAAWCSTFSCLRTSQTRDSAGFQGSPEMSALPSYVTFCHEHKTGRNLKIAIDRKATGTLSTILGSRSEPPKLAFTSKQPLKVHKAVITLEFLTRSGCAIDNRHFANNGSSRLDAGPASVTISWPISCGLGLSAVAAYTGICVDAVPEFPSTLCSSGNQIARNYRNTLIGKLIWFFERLTLNLVESLICDVSRQLNVLRQDISCFIYYDIRDIAIYAELSSSHSGVATAEKFTPRKIGREFGTLAGPVSRRNLIGRKSGPNSQSLPSISRMPATECAAPGRLMFQPLRYLKYRDTCIYLYCNVLLIRLLKIRRQPTTPRPPFWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRD1</accession>
    <name>A0A074ZRD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170367.1">
        <property type="nucleotide sequence ID" value="XM_009172103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRD1"/>
    <dbReference type="GeneID" id="20320937"/>
    <dbReference type="KEGG" id="ovi:T265_06758"/>
    <dbReference type="CTD" id="20320937"/>
    <dbReference type="OrthoDB" id="6248239at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="638" mass="72355" checksum="8C23D435C4086538" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRD5</accession>
    <name>A0A074ZRD5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167859.1">
        <property type="nucleotide sequence ID" value="XM_009169595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRD5"/>
    <dbReference type="GeneID" id="20318952"/>
    <dbReference type="KEGG" id="ovi:T265_04770"/>
    <dbReference type="CTD" id="20318952"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8249" checksum="187F735D4B6DFED3" modified="2014-10-01" version="1">MNRSVDRLRNTYSGRSNNRDLSNRSQSSDNEVFDQTTHGKDRLTEKKMSTDFRARVRSEKVVKEVLSPDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRG5</accession>
    <name>A0A074ZRG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166261.1">
        <property type="nucleotide sequence ID" value="XM_009167997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRG5"/>
    <dbReference type="STRING" id="6198.A0A074ZRG5"/>
    <dbReference type="GeneID" id="20317684"/>
    <dbReference type="KEGG" id="ovi:T265_03497"/>
    <dbReference type="CTD" id="20317684"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G patch" evidence="2">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120769" checksum="CDB828166F5CAC2D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTI3</accession>
    <name>A0A074ZTI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009167577.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20317351"/>
    <dbReference type="KEGG" id="ovi:T265_03164"/>
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    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="402"/>
        </location>
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            <begin position="1"/>
            <end position="22"/>
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            <end position="248"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="222"/>
        </location>
    </feature>
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            <begin position="238"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER30431.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51976" checksum="11D2AC1926B71B55" modified="2014-10-01" version="1">MAKRGVRDLRTPEKRNEKQQRTSAWSESTLVFQKERQALYIRPKIQVSLFMRNSGTLLRTYQALLCWCIPASVSVYSYSKVCSRVIQNVRGQSTGIIQEKDEISRLKNSANAVTGQEAAKSSERPISSMRIHIGGQPCYMKVNAEKSKKEESKMFSYIPGTVKCGFLIVAASLPKRMNESQLGSQKENEGDGTGAKMQCGETKNPGRHRSSTSLNVLPSSGTHLDVYDSRTAGRGGTANSARSSADSQSSFFLKPSKWPYGRNITRKSDSEFSNLRSFRRCALMPIQPRVNRSVSGEIHENNLTVTASDAPQLVTTIPHSNTPSITCEAPQNQTDVRIRRECKAVMQMLLNVLIYFVGWLPFFFVQIIEIWSPKELITYPTFAITFWARFCLTALNPFVVGYSSEELRKAFRSLIYCGHPKQEKKALKRLVLAGLGAAGIPYGRPIIPMRPHPVFERSSPTELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTY1</accession>
    <name>A0A074ZTY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20316936"/>
    <dbReference type="KEGG" id="ovi:T265_02748"/>
    <dbReference type="CTD" id="20316936"/>
    <dbReference type="OrthoDB" id="10540408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11447" checksum="52FC432651112C28" modified="2014-10-01" version="1">MTRGIYGVGVALSPRAERALLDWIPVNSSLRRPLSGCRHKKGCLFVVSAYSPTDGSSNSEKDPCIESYPRTFVKRKALTLWAICSMYKIKSKWSKPTGRVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUP4</accession>
    <name>A0A074ZUP4_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165376.1">
        <property type="nucleotide sequence ID" value="XM_009167112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUP4"/>
    <dbReference type="STRING" id="6198.A0A074ZUP4"/>
    <dbReference type="GeneID" id="20316975"/>
    <dbReference type="KEGG" id="ovi:T265_02787"/>
    <dbReference type="CTD" id="20316975"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58550" checksum="B60793F5D52AAB8E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUR7</accession>
    <name>A0A074ZUR7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166672.1">
        <property type="nucleotide sequence ID" value="XM_009168408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUR7"/>
    <dbReference type="STRING" id="6198.A0A074ZUR7"/>
    <dbReference type="GeneID" id="20327501"/>
    <dbReference type="KEGG" id="ovi:T265_13334"/>
    <dbReference type="CTD" id="20327501"/>
    <dbReference type="OrthoDB" id="6020735at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="687" mass="74075" checksum="8194631BB8A73048" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV79</accession>
    <name>A0A074ZV79_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV79"/>
    <dbReference type="GeneID" id="20317846"/>
    <dbReference type="KEGG" id="ovi:T265_03659"/>
    <dbReference type="CTD" id="20317846"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="17180" checksum="02DD706A2277F5A5" modified="2014-10-01" version="1">MMDIPSSSGQHTEITGEHIRDTLTRLSSVPDVSLLTALLLFQILMSPLKMILWYPNKTYLKNTQPVKCPKFPFQEDSKDCDQDHHWTINMHTLIQGVADAMNMTDTLFIYIFIIPLFEYSICGIYMPIRIHTCYWLRCAEFWISSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVC2</accession>
    <name>A0A074ZVC2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER27315.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009170706.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20327992"/>
    <dbReference type="KEGG" id="ovi:T265_13825"/>
    <dbReference type="CTD" id="20327992"/>
    <dbReference type="OrthoDB" id="6298486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="27736" checksum="08F6C53596FEE81B" modified="2014-10-01" version="1" fragment="single">MSSVCDAIVTIYSFDAPYSDVKPMYVTTREPESNGWDDLCDWLRHKRPYGWQLGLIDRCQVPKQDQGTVTMKIELFFHKLPHNLHTTPTDLQSWALNWMFWVGNEPCITIVDVPGRVLYDSLQLPRDQCNFCSAFASLVFEIVCVSSRKKFLRKSSNRRHSLRHEKPLGWLMGLFTRCQLHKEDRGTVTMKVELFVQNLPQFLHRSPTDLLSWLVNWLFWVKMEPCNTIGERTAINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVI0</accession>
    <name>A0A074ZVI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164720.1">
        <property type="nucleotide sequence ID" value="XM_009166456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVI0"/>
    <dbReference type="GeneID" id="20316440"/>
    <dbReference type="KEGG" id="ovi:T265_02252"/>
    <dbReference type="CTD" id="20316440"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12702" checksum="B14468EC87C1CDCC" modified="2014-10-01" version="1">MSDRAASAARTELERQEVPVSSFLEIQSKVGFKVSILIHGVPDLLKGLQNPGAQLAAEEIPVDLEYAEDIEQEKEAQISRQQLGVKQQEAMKTNKLLRLVAARITCRSADKTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW19</accession>
    <name>A0A074ZW19_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rab5 GDP/GTP exchange factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_05447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168718.1">
        <property type="nucleotide sequence ID" value="XM_009170454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW19"/>
    <dbReference type="STRING" id="6198.A0A074ZW19"/>
    <dbReference type="GeneID" id="20319629"/>
    <dbReference type="KEGG" id="ovi:T265_05447"/>
    <dbReference type="CTD" id="20319629"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="199"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60965" checksum="D72180D5A682955A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW81</accession>
    <name>A0A074ZW81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168637.1">
        <property type="nucleotide sequence ID" value="XM_009170373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW81"/>
    <dbReference type="GeneID" id="20327923"/>
    <dbReference type="KEGG" id="ovi:T265_13756"/>
    <dbReference type="CTD" id="20327923"/>
    <dbReference type="OrthoDB" id="6257405at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="495" mass="53713" checksum="DF6783834C68E5BA" modified="2014-10-01" version="1" fragment="single">IDLSHSPELPRSVGRIYAAPPCVRNLTHGSPTVTKSTCDAGLPRTFATGDTATQHSRVTRISSDTQSLFTSGKADLAIKQHTPSPGSRYPRLPSILSMQLPVSPPTTPKDADNIMEIVRHPSPQSAVPSLSSSPVNRLPREFQNPSAPLDVQVDKPPMMMSHTSTAVHTTTLDSTALSVFHSEEDQTKYRLKGSSSSSGCGPSPSTTVPVASSSSASSSLCESAPLRATPLITESTSPGLPKSVFARELRQHHRHSDGPSSDDGSCPTTDSILNWTKSDRKVDVADIRNEFISILSSGVQSRADTVDPGTVRPPASVLISRTERFSKALKARLDYLRTISCRAHDEAEAVAQLVNAIGLQCSTASKIISQCNSGCTIDRGKPSVCLPEVQDTLYRILMGVNMLLHNQLLDSALLLGQEQGKEFPSARKLPPRDRARLRQVARRRATIPLNCSSDSEFDELIGIKHKLMVDALRHCRLELNSNRQTVRCPRCKIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWF9</accession>
    <name>A0A074ZWF9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165989.1">
        <property type="nucleotide sequence ID" value="XM_009167725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWF9"/>
    <dbReference type="GeneID" id="20317466"/>
    <dbReference type="KEGG" id="ovi:T265_03279"/>
    <dbReference type="CTD" id="20317466"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11651" checksum="EB4038F1AC4EA3BF" modified="2014-10-01" version="1">MTTQTGLLALALSFLRTSDKFTIDSTVLSSAGEQIRSSLEEDPPSEPVKSTKRSVGHEEITPLGKKDVNPSLENVDMTRCWKNNLERMKSQLHSGEDENSCPAMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX22</accession>
    <name>A0A074ZX22_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SMG9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165802.1">
        <property type="nucleotide sequence ID" value="XM_009167538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX22"/>
    <dbReference type="STRING" id="6198.A0A074ZX22"/>
    <dbReference type="GeneID" id="20327336"/>
    <dbReference type="KEGG" id="ovi:T265_13168"/>
    <dbReference type="CTD" id="20327336"/>
    <dbReference type="OrthoDB" id="79514at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="87128" checksum="18A1EE7092DBE7A4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX78</accession>
    <name>A0A074ZX78_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164216.1">
        <property type="nucleotide sequence ID" value="XM_009165952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX78"/>
    <dbReference type="GeneID" id="20316030"/>
    <dbReference type="KEGG" id="ovi:T265_01842"/>
    <dbReference type="CTD" id="20316030"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="172"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="560" mass="63124" checksum="603142FF96696D19" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXC9</accession>
    <name>A0A074ZXC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597127">
        <property type="protein sequence ID" value="KER19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176396.1">
        <property type="nucleotide sequence ID" value="XM_009178132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXC9"/>
    <dbReference type="GeneID" id="20329609"/>
    <dbReference type="KEGG" id="ovi:T265_15444"/>
    <dbReference type="CTD" id="20329609"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="11928" checksum="23C22A73B66A3149" modified="2014-10-01" version="1" fragment="single">MSDVSDSNPGMTIGYALLMSSNQSETRVQCFPLVSTHRNNYTRPFKREWCDYEQNTYPTNAYMSACSVVKIKMLLACDDEIGVTGPPRMSDVRSSNPGTTNNMLMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXE6</accession>
    <name>A0A074ZXE6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FEZ-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zygin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165596.1">
        <property type="nucleotide sequence ID" value="XM_009167332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXE6"/>
    <dbReference type="STRING" id="6198.A0A074ZXE6"/>
    <dbReference type="GeneID" id="20317141"/>
    <dbReference type="KEGG" id="ovi:T265_02953"/>
    <dbReference type="CTD" id="20317141"/>
    <dbReference type="OrthoDB" id="7959977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011680">
        <property type="entry name" value="FEZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394:SF12">
        <property type="entry name" value="LD08195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12394">
        <property type="entry name" value="ZYGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07763">
        <property type="entry name" value="FEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56771" checksum="57B11DC47A05BA2C" modified="2014-10-01" version="1">MLNGETNLQEHDEADTVLSSLHALNLGSAFECELEKCFQLHPDLDFDETLNSHNTVHQTHAPGCLRLMLDFLPAIDPFDWRTSTLFREFINSLSLDSEQKPNGLNLDLPEDEDLAFAFDHHSLITSQLPDTYDDENEPIKTAEEVIREIDLIMGHDEDILLPSFGEPSPNGDAPLSGVAIDASPISESDLENLSLNQLNALLEELEACVREYSAVLVQELAYREELDFEQEQKDIFIARLDEMLRRLERRRRRCSMPPISSSLNPTVMDTVKPFDYEHGNDEFEASDFSSPSVVGHTDRPVGGQKCPAPVLSRAQSAAHAAVAAATSATALLKRQWHRLSRGPDELNSVEQNLLSDQCPVNSVRNPYERMDLHNSRICRSNNSSSGKSAPHPTVNSSRAATIVRLRKWASRKASEALNSGTSGSFRALLRRTAKRDAASGMVPMCIREARSAVTTPTSSQIELPTIPPTLTHSASGHLVGNQEISADILEYKITRARMLPMHHYMDRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXS3</accession>
    <name>A0A074ZXS3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164377.1">
        <property type="nucleotide sequence ID" value="XM_009166113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXS3"/>
    <dbReference type="STRING" id="6198.A0A074ZXS3"/>
    <dbReference type="GeneID" id="20316163"/>
    <dbReference type="KEGG" id="ovi:T265_01975"/>
    <dbReference type="CTD" id="20316163"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="22970" checksum="5A4EBC7B206748C3" modified="2014-10-01" version="1">MEHILHVTLPEATARAGKEIDQLTVIMDMQGLGLKHLSPSWLSLVGEAVTVIESNYPEVLGACFVINAPPLFSRLYSLVKPLLSKATQEKVQVLDSNYPETLLQHCDAESLPAVYGGSLIDPDGDPSCPSRICWAGPVPDSQINQSKQPHAPPPVIRVALSRSASAQSLGSSEQFSVVEVARGGQRDIPVGFLPVGVELSWCVVVFAKSFLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY56</accession>
    <name>A0A074ZY56_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">B-box zinc finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168029.1">
        <property type="nucleotide sequence ID" value="XM_009169765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY56"/>
    <dbReference type="STRING" id="6198.A0A074ZY56"/>
    <dbReference type="GeneID" id="20319087"/>
    <dbReference type="KEGG" id="ovi:T265_04905"/>
    <dbReference type="CTD" id="20319087"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="583"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="94767" checksum="C6400691D2747D6F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY58</accession>
    <name>A0A074ZY58_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165315.1">
        <property type="nucleotide sequence ID" value="XM_009167051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY58"/>
    <dbReference type="GeneID" id="20316924"/>
    <dbReference type="KEGG" id="ovi:T265_02736"/>
    <dbReference type="CTD" id="20316924"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705561" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="18186" checksum="CE95A6BD3C1BD587" modified="2014-10-01" version="1">MRKAGGFKLVLNSGLLFHLTECEKQIPYSGTTYVQPGDRCQNTSMEGASILRALEFIIGNSMAEIEQNSSKTTRSCITSKESSGRVNRSRQQRRQTEPTNAAVKTSRWKEKKVKWRYGYDLKKLVNDLPRVTECSFTRLQSRQIENKNPCNKLSSGIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ51</accession>
    <name>A0A074ZZ51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165009.1">
        <property type="nucleotide sequence ID" value="XM_009166745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ51"/>
    <dbReference type="STRING" id="6198.A0A074ZZ51"/>
    <dbReference type="GeneID" id="20327179"/>
    <dbReference type="KEGG" id="ovi:T265_13011"/>
    <dbReference type="CTD" id="20327179"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="35"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="652" mass="74565" checksum="42A16CF5FFEF843E" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZH5</accession>
    <name>A0A074ZZH5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167563.1">
        <property type="nucleotide sequence ID" value="XM_009169299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZH5"/>
    <dbReference type="STRING" id="6198.A0A074ZZH5"/>
    <dbReference type="GeneID" id="20318717"/>
    <dbReference type="KEGG" id="ovi:T265_04535"/>
    <dbReference type="CTD" id="20318717"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121324" checksum="02DFEB188763BA12" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZU5</accession>
    <name>A0A074ZZU5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163561.1">
        <property type="nucleotide sequence ID" value="XM_009165297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZU5"/>
    <dbReference type="GeneID" id="20315479"/>
    <dbReference type="KEGG" id="ovi:T265_01291"/>
    <dbReference type="CTD" id="20315479"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13664" checksum="E3D5F8A893A0792E" modified="2014-10-01" version="1">MEDMRRKSIPTEQLLLIQLHILFDECRPTGSDSETDFDFLLNKPRQTSSISALVLPSGGIEVFQLNQFTIGKLVALRLPQWDESDNSGFSEGTNFQESSCNISLRPRTVEPKAVAHTRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A060</accession>
    <name>A0A075A060_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163644.1">
        <property type="nucleotide sequence ID" value="XM_009165380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A060"/>
    <dbReference type="STRING" id="6198.A0A075A060"/>
    <dbReference type="GeneID" id="20315562"/>
    <dbReference type="KEGG" id="ovi:T265_01374"/>
    <dbReference type="CTD" id="20315562"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34555" checksum="C23975687AAE79E4" modified="2014-10-01" version="1">MDPAKKRCLRTRRPSDSSESEGEKTNDSNELVQQEDSTHVVEAIRELQKVRKRPPGISLSALSTGKAAPEETIIVSDPFKLKTGGLVEIRNAIRSKKTEEEDDVEARLAKTFATETNKRDEDAEMIKYIEEEIARRKGLRRTPSPESNAGADLLRDVPEYLRPVIGQQKEDMLSNQMLCGIPEVDLGVDAKMRNIEATEEAKQTLLKHRFNRGYGMASDGLAPTNVAVNFVQHSRWNSHNATTTFSSGDYTRDLLNIASKANPHKTDIVQQQTTGLDAERERLGAERSTDSLVLQRFKSHMRGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0N6</accession>
    <name>A0A075A0N6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597005">
        <property type="protein sequence ID" value="KER20979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175271.1">
        <property type="nucleotide sequence ID" value="XM_009177007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0N6"/>
    <dbReference type="STRING" id="6198.A0A075A0N6"/>
    <dbReference type="GeneID" id="20324758"/>
    <dbReference type="KEGG" id="ovi:T265_10590"/>
    <dbReference type="CTD" id="20324758"/>
    <dbReference type="OrthoDB" id="9979394at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF54">
        <property type="entry name" value="SPHINGOSINE KINASE RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="528" mass="58513" checksum="ADD22EB870E1CFAB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0U0</accession>
    <name>A0A075A0U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164354.1">
        <property type="nucleotide sequence ID" value="XM_009166090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0U0"/>
    <dbReference type="GeneID" id="20316140"/>
    <dbReference type="KEGG" id="ovi:T265_01952"/>
    <dbReference type="CTD" id="20316140"/>
    <dbReference type="OrthoDB" id="6153140at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16272" checksum="E69E5DB5C84EF8F1" modified="2014-10-01" version="1">MPINPALKLKLDELFLRWLTDPATQKVLHENLIQIKANESLQTMLAVPSGVVVGPMPSSFYSFFYGSLACDSPGPPTDGVLGVNGTMGSLVSPRPNTPPYFPQPPHTKMFSPRSPRRQAPSSAQPNASAKVSFDRFAAYIYMWIFCGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A150</accession>
    <name>A0A075A150_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kunitz/Bovine pancreatic trypsin inhibitor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164302.1">
        <property type="nucleotide sequence ID" value="XM_009166038.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A150"/>
    <dbReference type="GeneID" id="20316100"/>
    <dbReference type="KEGG" id="ovi:T265_01912"/>
    <dbReference type="CTD" id="20316100"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000011">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705577" description="Kunitz/Bovine pancreatic trypsin inhibitor domain protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="357"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="542"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="697"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="907"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1699"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1893" mass="212496" checksum="D6EFB294D2D2011B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A291</accession>
    <name>A0A075A291_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162296.1">
        <property type="nucleotide sequence ID" value="XM_009164032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A291"/>
    <dbReference type="GeneID" id="20314475"/>
    <dbReference type="KEGG" id="ovi:T265_00287"/>
    <dbReference type="CTD" id="20314475"/>
    <dbReference type="OrthoDB" id="6243982at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704489" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="224" mass="24999" checksum="E71DE0CCB74AE040" modified="2014-10-01" version="1">MSSQLNGMRRAVILLVVCTGFFCLATDNEAETMNNGLVVQGHQDSGAVQCLTCKFVAHVALNWIQKPSTRDTLSQKIQRSCEDSHSKLCSLIANQSLAYVFNTINNITSEQFCVLYEFCQNVAKPDCNRCHLLSDSFGCYNLPCFHSLSTICCATLAEMRRILLATDVQQELFKEMIGACKRYSAVYAVCKVVMKTVYNDVINQVKEFHPEGFCKQAAICPATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2M6</accession>
    <name>A0A075A2M6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AGC-kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_03604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166403.1">
        <property type="nucleotide sequence ID" value="XM_009168139.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A2M6"/>
    <dbReference type="GeneID" id="20317791"/>
    <dbReference type="KEGG" id="ovi:T265_03604"/>
    <dbReference type="CTD" id="20317791"/>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="3593"/>
            <end position="3627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1144"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2648"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1492"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3467"/>
            <end position="3515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3627" mass="413884" checksum="441DB0EEA1E57298" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A354</accession>
    <name>A0A075A354_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162100.1">
        <property type="nucleotide sequence ID" value="XM_009163836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A354"/>
    <dbReference type="STRING" id="6198.A0A075A354"/>
    <dbReference type="GeneID" id="20326588"/>
    <dbReference type="KEGG" id="ovi:T265_12420"/>
    <dbReference type="CTD" id="20326588"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="376" mass="42644" checksum="5A72E063079D3BC2" modified="2014-10-01" version="1" fragment="single">ARWLKWLERESTDRKFRGSNPTSASRFPLSNLGQPDSIPALVLPLGSMTARHRMGVTAERRYNPSVIFPKRITKNHGMVCDTCWSTEHCFQHCEGEEHPNLLGVFRSVLHLLMLSTLHLSVAGRRRSVAAVQLLILSPLLEVCCSLNSSRGVDHHKSQLGSVVPDENEVFRLLRLQNSVGDELFLDYVVENWLQLAHRLAKLSQGMATRIFLETVERFASKSTHKVTLLYVKATLAFVEGQYQLSRDLLAETTKLDPSDENFWLACTILRMDTLSADPNLAARRLPAADVLLDFEPSLRRRIPMHFGQNAVLEDLKATEAQLTRRPDAWPFRAGWYAYQRGLLLARQGELEARLDESSHQLTQIHFHPISLVVPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A386</accession>
    <name>A0A075A386_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MITD1 C-terminal phospholipase D-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162292.1">
        <property type="nucleotide sequence ID" value="XM_009164028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A386"/>
    <dbReference type="STRING" id="6198.A0A075A386"/>
    <dbReference type="GeneID" id="20314471"/>
    <dbReference type="KEGG" id="ovi:T265_00283"/>
    <dbReference type="CTD" id="20314471"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MITD1 C-terminal phospholipase D-like" evidence="2">
        <location>
            <begin position="430"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="62577" checksum="EC515B145483EF8E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3Y6</accession>
    <name>A0A075A3Y6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165975.1">
        <property type="nucleotide sequence ID" value="XM_009167711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3Y6"/>
    <dbReference type="GeneID" id="20327361"/>
    <dbReference type="KEGG" id="ovi:T265_13194"/>
    <dbReference type="CTD" id="20327361"/>
    <dbReference type="OrthoDB" id="6253859at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="417" mass="46078" checksum="63BC693045048220" modified="2014-10-01" version="1">MNPFEKRDKIPRTPPGHSFMERSLNDLDQTGVGDCSLYDESGVRSSCVPENLKRYTLTFNPSPKDSRPLAPSQRYSWMLNGQLAMFTSSPVRSEKTCAIVLTKIPSRDEVDDNKENLAIQSSVVEPGTVRPRGKRRKDISQRSGDQDSIFPTPNDSSLDTASAEPATIRRLRSRDVSVDGSTLSIAAHPRSKRRKQADSLGSSDSSYSSTDLQQRSTTKSNTRRGRRNAVHRSVLKPQTPLHSTAVEPMTPCTVVAKPMRTSTAEEQTSPVPMTVVRREPIATVVKLPAKREVRMGNLISKDGAPSPTTDSEVDQPETVLRPSRAKLAPTSVPCSVTLDVLDFSTITPASSRQRRRRVLSKLDSLSQDAEPIAARLRRNATQVSYLEPRMTRDTTALELNSDASLPYNHDLIESLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4L2</accession>
    <name>A0A075A4L2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163049.1">
        <property type="nucleotide sequence ID" value="XM_009164785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4L2"/>
    <dbReference type="GeneID" id="20315078"/>
    <dbReference type="KEGG" id="ovi:T265_00890"/>
    <dbReference type="CTD" id="20315078"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8020" checksum="9C6DC9913964B7D9" modified="2014-10-01" version="1">MLTLCKNYQAGSNDMRSKSRRTIKINGAEALEDDIQGHPAKKRKSEGLPPYGEAAVEKPTTRSDKRRQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4N4</accession>
    <name>A0A075A4N4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596902">
        <property type="protein sequence ID" value="KER22374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173873.1">
        <property type="nucleotide sequence ID" value="XM_009175609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4N4"/>
    <dbReference type="GeneID" id="20323684"/>
    <dbReference type="KEGG" id="ovi:T265_09515"/>
    <dbReference type="CTD" id="20323684"/>
    <dbReference type="OrthoDB" id="6288054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44521" checksum="4DE64443A28597D3" modified="2014-10-01" version="1">MVYFTTASIFPPTPTSVSIQTEQRAINPRVVADPTQAPNDLVFLLHRDVLIECVEFGLKDTNAEIRSLAEQLLVCLLNSYELLSRSSWCTLYHLILDTCAPGACSSVASTYPLSVIFGPHAAPPSVDRGANPAFGELVLDWCLGLMTPSGRRPAACGWKPVLLDESVNSHKISHSCGRLLFHPDAKVREAAATAFAEHFRAFCSGYSQPAHPVEGSTSTATESRVVTGMSVSTECADASKPVGMHKTSTPVDRNSSELLLVQTLMNGLVFGADSSSGQQQIPSFVLDHQDNILSGPVDTDQADNVPRLMQALIDCGSDLDVRRAAGEQLLFLIRSPLILEAWLVNQGLQQCRRLVEQTVEEHIVNSARTKSPDPYHTLIPPDSSSSVYFLVADASVQRRLETQHSTTVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A539</accession>
    <name>A0A075A539_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165549.1">
        <property type="nucleotide sequence ID" value="XM_009167285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A539"/>
    <dbReference type="STRING" id="6198.A0A075A539"/>
    <dbReference type="GeneID" id="20317109"/>
    <dbReference type="KEGG" id="ovi:T265_02921"/>
    <dbReference type="CTD" id="20317109"/>
    <dbReference type="OrthoDB" id="9973021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="74027" checksum="CE6EB5CD09149C57" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5G8</accession>
    <name>A0A075A5G8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162780.1">
        <property type="nucleotide sequence ID" value="XM_009164516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5G8"/>
    <dbReference type="STRING" id="6198.A0A075A5G8"/>
    <dbReference type="GeneID" id="20326763"/>
    <dbReference type="KEGG" id="ovi:T265_12595"/>
    <dbReference type="CTD" id="20326763"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="835" mass="92063" checksum="C228E09727EE5A49" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A640</accession>
    <name>A0A075A640_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173330.1">
        <property type="nucleotide sequence ID" value="XM_009175066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A640"/>
    <dbReference type="STRING" id="6198.A0A075A640"/>
    <dbReference type="GeneID" id="20323260"/>
    <dbReference type="KEGG" id="ovi:T265_09081"/>
    <dbReference type="CTD" id="20323260"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="474" mass="52630" checksum="29396A24A06107A1" modified="2014-10-01" version="1">MSAYNQTELNCVEWPNLVKFSQLYAKLHGYLALIVCVFGSVTNILNAIILTQRSMRNPTNVILTGVASGDLVTMIAYGIYAVYLNVLTAPSPDEYTHSLAMVRVILITQGLILGSHTFSTVLLVVLAVLRCRIMYVVTLGRGSKSHGKTGVQPNAQKRIVLVGFAVGIVLGLTVGIPVHFIYEIELRPHNQTSQMNVTHSLMSYWFDIRPGADGLEHGHFVLNGVFVKILASVLIFVLTSFLLVTMRIAEKHYQELQMLSGKKPAKLVQAERANTEDLTKTRVGTNTNSEVVPSMRISCSNTSNEKPSMLRLINKTRQTQRATVMLIILVISFVVTEAPQGVVNTLVAIKGDCFHNNVYVPLGDILDLLVLMNSSVNFILYCAMSQMFRVHFRHLIAKCCCPSMCVEARGQRDLTNRPPSAWATTNMPMHVETCYQHTWMRSKKVISNTPVILLNAPASSDGIVHDKTDERVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6Y2</accession>
    <name>A0A075A6Y2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164858.1">
        <property type="nucleotide sequence ID" value="XM_009166594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6Y2"/>
    <dbReference type="STRING" id="6198.A0A075A6Y2"/>
    <dbReference type="GeneID" id="20327148"/>
    <dbReference type="KEGG" id="ovi:T265_12980"/>
    <dbReference type="CTD" id="20327148"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="525" mass="57597" checksum="08DEBE11B8B4C695" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6Y5</accession>
    <name>A0A075A6Y5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium:neurotransmitter symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173083.1">
        <property type="nucleotide sequence ID" value="XM_009174819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6Y5"/>
    <dbReference type="STRING" id="6198.A0A075A6Y5"/>
    <dbReference type="GeneID" id="20323070"/>
    <dbReference type="KEGG" id="ovi:T265_08891"/>
    <dbReference type="CTD" id="20323070"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28860" checksum="00ECD9DFFB536346" modified="2014-10-01" version="1">MGIPAHIYAKLFYLPTQKQPQWPVTCQIAAILLTGAFLFGGVKWIERANLVLVPILLIILIFTFGWSLTRPHAEVGIKFLFTPTWESFAQPGLWIAAASQNAFDTGAGLSVLFTYATYMGRSASITKYSLFIPIMNNLVSLYASIAIFSTVFSTLIGEDGAITRSAILQIMQQSGPGSTGLTFTWIPVLFSNFGTLGRVLCALFFLCLIFAGLSSLLANIQVYILAAKEIGVPHRIAVTSSLLACFAVGLPSAIKLEILENQISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8L2</accession>
    <name>A0A075A8L2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172422.1">
        <property type="nucleotide sequence ID" value="XM_009174158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8L2"/>
    <dbReference type="GeneID" id="20322553"/>
    <dbReference type="KEGG" id="ovi:T265_08374"/>
    <dbReference type="CTD" id="20322553"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21803" checksum="7BE4F834A830588C" modified="2014-10-01" version="1">MPYFSTSESHLIEFTTSHSPRNPSLVGFRGTFYTGPSQCLHFADDLKPWGSNAIALQMNVETAKKSLDWHLPPNHEKARRPYEDRSQKGFWDLAIFKHVLFTAPLETDPKRIRLSTDNLAYFEYTNEVVHSRRTKGVPLIGRIQSHFTGRDPCVEILVARACVPLFDYVIVELFVEFGNKSAKVSSLVDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8P2</accession>
    <name>A0A075A8P2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596832">
        <property type="protein sequence ID" value="KER23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172403.1">
        <property type="nucleotide sequence ID" value="XM_009174139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8P2"/>
    <dbReference type="GeneID" id="20322542"/>
    <dbReference type="KEGG" id="ovi:T265_08363"/>
    <dbReference type="CTD" id="20322542"/>
    <dbReference type="OrthoDB" id="6238433at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="231" mass="26101" checksum="04C81948E90105E5" modified="2014-10-01" version="1">MCVPSPGNPDSLNSSKVYGASSGSLPGSSLGLNEENLSRKVTRRFRCPVFLSLSLPPELDAIWDKIDPCTQETFSKDVEAALFDHLNAHFEPFSLTTSLTYGERWIMRPPDKEFDCLLYWLKETLHVSFGQSNSTSTIIIIDSMTSVFNTDASLPYNHDLLESLIVKKRTHWIRLKLMYAACQKQVLKIQKRSPSQLPHNSPLGFSSATLTIQKPVYCWHRFKSLTGKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8Z2</accession>
    <name>A0A075A8Z2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164129.1">
        <property type="nucleotide sequence ID" value="XM_009165865.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A8Z2"/>
    <dbReference type="GeneID" id="20315963"/>
    <dbReference type="KEGG" id="ovi:T265_01775"/>
    <dbReference type="CTD" id="20315963"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144054" checksum="31EF1EBE65AB1783" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9B9</accession>
    <name>A0A075A9B9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172135.1">
        <property type="nucleotide sequence ID" value="XM_009173871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9B9"/>
    <dbReference type="GeneID" id="20322330"/>
    <dbReference type="KEGG" id="ovi:T265_08151"/>
    <dbReference type="CTD" id="20322330"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="17680" checksum="DB32DCADEBE7825C" modified="2014-10-01" version="1">MVQERFGTAAERKRTAVQVGCGYAYELPTTPEPTPEAACLADTTALGTVDPPAGPEGGMDAWKHSTVTDMHVFQQLIQLSIIAHTEHDVTGSDSLPAGQSEWGNIELEKKARRKQNNTQNKTNGVHEPIDSTGSIGYFRFTDGKARIPTQQSPHDLTLYSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9I7</accession>
    <name>A0A075A9I7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163774.1">
        <property type="nucleotide sequence ID" value="XM_009165510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9I7"/>
    <dbReference type="GeneID" id="20315657"/>
    <dbReference type="KEGG" id="ovi:T265_01469"/>
    <dbReference type="CTD" id="20315657"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8450" checksum="A4D2D8FA6FE179FE" modified="2014-10-01" version="1">MISRLVFATDLQTWIMFKGITELEPASCLSMDFVGGVAMNPSSNDMGCYMHPTGCSHIILAATTEEHYIGTSVDSCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC01</accession>
    <name>A0A075AC01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171044.1">
        <property type="nucleotide sequence ID" value="XM_009172780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC01"/>
    <dbReference type="GeneID" id="20321472"/>
    <dbReference type="KEGG" id="ovi:T265_07293"/>
    <dbReference type="CTD" id="20321472"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="14109" checksum="30B3F0B39A31C279" modified="2014-10-01" version="1">MDELQQNIKGATLTEFSTVYPTSPIRPQEQWISSRSLVLTVACRQRVRRRTHIPQTPNNKEPRGRSRALDLEYKKFSQGQGDAMQYNMVHAHAMRSYLPPPKSSVNETVASTTTVRRVRGYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC17</accession>
    <name>A0A075AC17_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162842.1">
        <property type="nucleotide sequence ID" value="XM_009164578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC17"/>
    <dbReference type="GeneID" id="20314917"/>
    <dbReference type="KEGG" id="ovi:T265_00729"/>
    <dbReference type="CTD" id="20314917"/>
    <dbReference type="OrthoDB" id="10346404at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13800" checksum="BC3CBAB44D01AA10" modified="2014-10-01" version="1">MDDAFAVPITSEEDDNRPDYCYTGCAPVTKDEEVTSQEDNHRSVCGSLRCAPISMDNKHSSEDYSAHSHCGFLGCAPLTTCEQAVPPTMGAGFYGGSLYPSVEVTHMGIIHFQTVSTQCLRFDKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEL3</accession>
    <name>A0A075AEL3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169385.1">
        <property type="nucleotide sequence ID" value="XM_009171121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEL3"/>
    <dbReference type="STRING" id="6198.A0A075AEL3"/>
    <dbReference type="GeneID" id="20320151"/>
    <dbReference type="KEGG" id="ovi:T265_05969"/>
    <dbReference type="CTD" id="20320151"/>
    <dbReference type="OrthoDB" id="6246804at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="315" mass="35979" checksum="928C987D0E5E7943" modified="2014-10-01" version="1">MLAAFSTVCSTSPIPPQDPWMSSRSLSMIDARKAIPAGNEYDGARKSLKRQISLRKDRELWWTSKAREMEKAFATGNSRVLYQLIRSTGPRKATVSETISEKDGSLIHSRNRRLERWAEHFEEQFSWPPATQPVAQSRPQWRSSFSNPNPPLDIPLTVLDLCTNLPARACNAQLPTPLQIIGKRNCGSYNQCTTSTRFLQLTMVMMTQKDIMIRINRRRNTLICELIRFFERFTWNPAESLVCDVSRQLNVLHRAASCFSRYDIRDITIHSLFKIRRQPTTGFALLGAHQVGAVPGNITNERFSWVPGESLEKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF86</accession>
    <name>A0A075AF86_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168790.1">
        <property type="nucleotide sequence ID" value="XM_009170526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF86"/>
    <dbReference type="GeneID" id="20319686"/>
    <dbReference type="KEGG" id="ovi:T265_05504"/>
    <dbReference type="CTD" id="20319686"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10443" checksum="95C0F2E06D462EEC" modified="2014-10-01" version="1">MGGITLLLDDFPHNSIRFCKSKAQSCSETSSFQDVEKCTPNTLIDELDSCQKHALSKTAGSAPKTAMVEVFAPLNTFLEGVAQLQLIRIYLIMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFN9</accession>
    <name>A0A075AFN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168297.1">
        <property type="nucleotide sequence ID" value="XM_009170033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFN9"/>
    <dbReference type="GeneID" id="20327851"/>
    <dbReference type="KEGG" id="ovi:T265_13684"/>
    <dbReference type="CTD" id="20327851"/>
    <dbReference type="OrthoDB" id="6245045at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="54539" checksum="4B0A966A700964E2" modified="2014-10-01" version="1" fragment="single">IGTKKFKPVLFIRPDPARSNPTQQIHSASYKSRGYGDIFQSKIESGPRPNTRCFSASSSLGRAKATQHRRTGERSPVSPSFTISPYDEHTGRMGNLYLFNSLPQPTPTHAWTKLDNGIKEEKQSPFWNVENALPPQVSGVERVSVDRQAIREITTKEVELKAALAGVPSPRTPDALLKSPKLLSPLLISTKLLGNTPNIGNSKSPSPRPSPITDKLSCIAAPLDLAEYDQSDDLSASFEASLLASLKEAATGAACRQSGLELGMEANGISNAFTTTIGKKHAEVSEKQQGCPAELRPRLNIPPRHSKPGLIGNSQTPENLQLRKLIENEFQTDISYSDDDTSMATTTAGLGSLLDSPFPESYVEGRKKEYPGFPSSKGSFNPETKLGAPLLYTDGISVHPSHPSNSRQHADEGPSSSTTSSSCWQLHSASSEPNLVSGSVEPVCLPNNPLLPELTNSAPTNNPSPTGPGDIDSPDKCIQDTVLELLYDAVLDCYYDPSSGVYYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFT7</accession>
    <name>A0A075AFT7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168176.1">
        <property type="nucleotide sequence ID" value="XM_009169912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFT7"/>
    <dbReference type="GeneID" id="20327822"/>
    <dbReference type="KEGG" id="ovi:T265_13655"/>
    <dbReference type="CTD" id="20327822"/>
    <dbReference type="OrthoDB" id="6247498at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9368" checksum="DA3A7E6B62EEC91A" modified="2014-10-01" version="1" fragment="single">MANRDDEQSEDIRMVGKVHIFQWRRTSGLKVSAKVSEVRPFPEYEDVDHLSDNEMVLNAEPGTYAHKLKQPMMEVIRNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGQ2</accession>
    <name>A0A075AGQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167302.1">
        <property type="nucleotide sequence ID" value="XM_009169038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGQ2"/>
    <dbReference type="STRING" id="6198.A0A075AGQ2"/>
    <dbReference type="GeneID" id="20318511"/>
    <dbReference type="KEGG" id="ovi:T265_04329"/>
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    <dbReference type="OrthoDB" id="10264920at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF2">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="333"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="427" mass="47212" checksum="4BE1D35B161DF122" modified="2014-10-01" version="1">MISNVSGPIPTHEVYFDAPILHEQQKLLNPFEHLGILQWESNTSSVHSNRPVTASAEKLTPQVAQIHKSCSGLPHPDGNIIFRETIGTDTAAQKNIENPPAKTGLGDQSTLNDDQSTECSMDPHSSGFQPNVGSPEVRVSRRQDSRPPLQCRATQCSIQERARTVSQGVQVNAVESPRQGSSVPPKGRQAQPKRPTSVQSSRIRAASAGPAKRDFLRAHEKTTPGKCTLEELGNIPLNKPVWTPRPERLSVPAASSAKTVQLIRRNINYVRANAHLIGISSRNSSSRGSNVAGSEPTSHLNSPKRSQVAHVREPHMWPERQLPVGGLPAYLIRERHQAAAAAAQEAASRPDPDQPPGHVRMPDADRVNTLELLRKAHAELTEEWFKLPVRMDTMRIRVRRSELEQRLIELEQAISIFEKPKVFIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHA4</accession>
    <name>A0A075AHA4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166684.1">
        <property type="nucleotide sequence ID" value="XM_009168420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHA4"/>
    <dbReference type="GeneID" id="20318026"/>
    <dbReference type="KEGG" id="ovi:T265_03839"/>
    <dbReference type="CTD" id="20318026"/>
    <dbReference type="OrthoDB" id="6229456at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="782"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="870" mass="98540" checksum="3E39C5AA7AFD0268" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHG5</accession>
    <name>A0A075AHG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-binding enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_03637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166436.1">
        <property type="nucleotide sequence ID" value="XM_009168172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHG5"/>
    <dbReference type="STRING" id="6198.A0A075AHG5"/>
    <dbReference type="GeneID" id="20317824"/>
    <dbReference type="KEGG" id="ovi:T265_03637"/>
    <dbReference type="CTD" id="20317824"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="720"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118275" checksum="CF767404FF73B694" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIA6</accession>
    <name>A0A075AIA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164994.1">
        <property type="nucleotide sequence ID" value="XM_009166730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIA6"/>
    <dbReference type="GeneID" id="20316669"/>
    <dbReference type="KEGG" id="ovi:T265_02481"/>
    <dbReference type="CTD" id="20316669"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12602" checksum="FE58ED0A0013C119" modified="2014-10-01" version="1">MSQAAHSKTIDDHGLDHEIDGILVSLTPKLLIGSETPALLKTTGGQYKVAKDVPGIPLRFAFRLNNAARCTSKEMAEHEAQHRVKNVSGAYAVERRVVNRVVFRNIWKLRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJX9</accession>
    <name>A0A075AJX9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation diffusion facilitator family transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161955.1">
        <property type="nucleotide sequence ID" value="XM_009163691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJX9"/>
    <dbReference type="STRING" id="6198.A0A075AJX9"/>
    <dbReference type="GeneID" id="20314222"/>
    <dbReference type="KEGG" id="ovi:T265_00034"/>
    <dbReference type="CTD" id="20314222"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="71"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46287" checksum="5DB17D6F91D44542" modified="2014-10-01" version="1">MSSIHVALGFFCQPMPAEDTRYLIDEGNYWLDIPDERTPLSPSRRFTDASRGHCHDDTTDRGIDKRAKRKLLIASGLCLCFMIGEVVGGALAQSLAIMTDAAHLLTDFASFLISLLALFLAQRPSTKKMSFGWHRAEVVGALASVLMIWLVTGILVYLAVMRIMNNHYDIDGKIMLITSAVGVGVNIIMLLTLHDHGHGHSHAAPKETSPLTALSHNHESVHANGTKLDHEKHSHQHGHGGEHVHQVSPKLEQESKRQNITVRAALIHVIGDLVQSVGVMIAAMIIYFRPKLKVVDPICTFLFSILVLITTINVLRDALSVLMEATPRGLDFNDVKNALNDVPGVVELHNLRMWSLTMNKTAVSVHLAVEPQADPQEILYQASTLLRKRYLVHEVTIQLEPYSAEMADCQRCQEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXW8</accession>
    <name>A0A074YXW8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_15522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597191">
        <property type="protein sequence ID" value="KER19513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176745.1">
        <property type="nucleotide sequence ID" value="XM_009178481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXW8"/>
    <dbReference type="STRING" id="6198.A0A074YXW8"/>
    <dbReference type="GeneID" id="20329687"/>
    <dbReference type="KEGG" id="ovi:T265_15522"/>
    <dbReference type="CTD" id="20329687"/>
    <dbReference type="OrthoDB" id="6101876at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER19513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10658" checksum="A08C76135F487CFC" modified="2014-10-01" version="1" fragment="single">MSGRGKANEELGKRGAKRHRQVLRDNIQEVTKPAIHHLARRSGVKGIPGLTYEETRGVLKLFVENVIRDAVTEQVKRKSVTALKRQRCTFYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ06</accession>
    <name>A0A074YZ06_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597103">
        <property type="protein sequence ID" value="KER20026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176222.1">
        <property type="nucleotide sequence ID" value="XM_009177958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ06"/>
    <dbReference type="STRING" id="6198.A0A074YZ06"/>
    <dbReference type="GeneID" id="20329573"/>
    <dbReference type="KEGG" id="ovi:T265_15408"/>
    <dbReference type="CTD" id="20329573"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF153">
        <property type="entry name" value="SERINE PROTEASE HEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="48"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="27722" checksum="F16D78E537019C8C" modified="2014-10-01" version="1" fragment="single">TARIQANPWLFSPLVENIDRYCGLREDDRQWSSQFETETNVLHISKRIVGGIKSKLGEWPWLVSLMFYETAEEIKSNLVGKHGNGSIFIPPTIITYYPSGSRRYHICGGTLIHPQWVLTAAHCFFMMICLFCYSPAGAHIYLSPAPYRWRVRAGEYDMLDDRTDHEDIDVEAVYPHPDYNGMLIYIYDSGGPLMCKSSNQWYVVGVVSFGYECGAPDLPGVYTNVSFFTKWIADIVPDISFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZN8</accession>
    <name>A0A074YZN8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597075">
        <property type="protein sequence ID" value="KER20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176012.1">
        <property type="nucleotide sequence ID" value="XM_009177748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZN8"/>
    <dbReference type="SMR" id="A0A074YZN8"/>
    <dbReference type="STRING" id="6198.A0A074YZN8"/>
    <dbReference type="GeneID" id="20325329"/>
    <dbReference type="KEGG" id="ovi:T265_11161"/>
    <dbReference type="CTD" id="20325329"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="595" mass="65509" checksum="37B67D9937C8E268" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Y8</accession>
    <name>A0A074Z0Y8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597321">
        <property type="protein sequence ID" value="KER19127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177126.1">
        <property type="nucleotide sequence ID" value="XM_009178862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Y8"/>
    <dbReference type="GeneID" id="20326160"/>
    <dbReference type="KEGG" id="ovi:T265_11992"/>
    <dbReference type="CTD" id="20326160"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="334"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="714"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="798" mass="88811" checksum="E98C3A7AD537FCEC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2J7</accession>
    <name>A0A074Z2J7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596979">
        <property type="protein sequence ID" value="KER21281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174977.1">
        <property type="nucleotide sequence ID" value="XM_009176713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2J7"/>
    <dbReference type="STRING" id="6198.A0A074Z2J7"/>
    <dbReference type="GeneID" id="20324530"/>
    <dbReference type="KEGG" id="ovi:T265_10362"/>
    <dbReference type="CTD" id="20324530"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="279" mass="31374" checksum="E06921BD048BBADE" modified="2014-10-01" version="1">MRILALAGMLPRSENIKSSATPFSLVSFGRGRNFIVGEYNGNSSETFVGGERVIFKLEHSHQRIRNMFCPGDLWLYPNSNISQGSIFLWLPKGLILFALFYTIGNILSLGSTIFLMGPMNQLRRMFQETRIFAAVIMLICMAMTICAAVWWKNKLLCLIFCILQSGALTWYSLSYIPFARCSTLSVPNCHATKRKHEGWDTARLPKPRQGKSRGGGTFRSANSRSNHLGYLALRSSHAGRCESLLHINDRLMMLNLSPYIPSEADTVLTLSATYYHTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2L0</accession>
    <name>A0A074Z2L0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597145">
        <property type="protein sequence ID" value="KER19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176515.1">
        <property type="nucleotide sequence ID" value="XM_009178251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2L0"/>
    <dbReference type="GeneID" id="20329628"/>
    <dbReference type="KEGG" id="ovi:T265_15463"/>
    <dbReference type="CTD" id="20329628"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="23764" checksum="BE8A6F1E3D00BAAD" modified="2014-10-01" version="1" fragment="single">EQVSRRLTELAAVRFPTVLGANDSLLGCKTTLRYRIRHKTPSYDQILVKKTQTSAFNYPHQLHHQDAPSFNSSYQAADKVDNKTERANTTGVQQDSLSNIIWGGLDFLTSWFPHWRLGVQNDSATKRSPVMCAFCGKVSTAQTFYHLLNGSMTDFQTVLESTTLSELLKLFAVKLSYIFQEQKFRSPTHAQPLPTKVSLIFNYETPAEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2S8</accession>
    <name>A0A074Z2S8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596972">
        <property type="protein sequence ID" value="KER21371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174892.1">
        <property type="nucleotide sequence ID" value="XM_009176628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2S8"/>
    <dbReference type="GeneID" id="20329271"/>
    <dbReference type="KEGG" id="ovi:T265_15106"/>
    <dbReference type="CTD" id="20329271"/>
    <dbReference type="OrthoDB" id="6236829at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703914" evidence="2">
        <location>
            <begin position="23"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="784" mass="87790" checksum="4DDC2C4302C61D4C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z321</accession>
    <name>A0A074Z321_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Family with sequence similarity 183 member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFAP144 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596970">
        <property type="protein sequence ID" value="KER21398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174863.1">
        <property type="nucleotide sequence ID" value="XM_009176599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z321"/>
    <dbReference type="STRING" id="6198.A0A074Z321"/>
    <dbReference type="GeneID" id="20329266"/>
    <dbReference type="KEGG" id="ovi:T265_15101"/>
    <dbReference type="CTD" id="20329266"/>
    <dbReference type="OrthoDB" id="446290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029214">
        <property type="entry name" value="CFAP144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33865">
        <property type="entry name" value="PROTEIN FAM183B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33865:SF3">
        <property type="entry name" value="PROTEIN FAM183B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14886">
        <property type="entry name" value="FAM183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="24204" checksum="4CD147DB937D9164" modified="2014-10-01" version="1" fragment="single">YLGAEILRIAHLQINLIFTGDSTESLVYDAFQLNVLHTSRLMIHLATIFKISQYISIPHLFDCDARLLINKRKMTTNASREINFVHQAEIMTETIKKELRHQKLYTQYGINPFKKLCPLASKPNAEQREEEEDKHFLEVLNRAALEPTKKYLEPETENQEYGWISLPLMDMDRSDARFYHPNVACEMTKFMEQTWKQKEQRRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z393</accession>
    <name>A0A074Z393_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Core-2/I-Branching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596959">
        <property type="protein sequence ID" value="KER21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174708.1">
        <property type="nucleotide sequence ID" value="XM_009176444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z393"/>
    <dbReference type="STRING" id="6198.A0A074Z393"/>
    <dbReference type="GeneID" id="20324324"/>
    <dbReference type="KEGG" id="ovi:T265_10156"/>
    <dbReference type="CTD" id="20324324"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF185">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="44503" checksum="E1AB305152217DCE" modified="2014-10-01" version="1">MPSRISVCATGTFVLVTGCIIYHCWRSHFDEKVCLRQLNRTYDCLKCLGISVPLYEYTITSVERDFPLAYSILVYTDPERAVRLLAAIYRPHNFYCIHVDRKSPNGLVRWLMLCGQCFNSNVFFVPDEQRTAVRWGYFSVLEPELTCTRLLLRRSGKWKYWINLTGQEFPLRTNRELVLALKALNGTNVVLATYRRRSIQRIPPRSVKSQNIIWYKGAVHVAVRREFVNFMLKDKKAIWLLEELKEYETSVGKEIIIDETFFATLNHNPDVFPIPGAVLHVNETRTGSELVRYKVWSDDETRCHSGRAVRQICMLGTLDLPYLFQSPAFFANKFIPQVEPTAYAAMELWLALKCSYESSHHVPHPTFDQNYYARKPIAWDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3D9</accession>
    <name>A0A074Z3D9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174682.1">
        <property type="nucleotide sequence ID" value="XM_009176418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3D9"/>
    <dbReference type="STRING" id="6198.A0A074Z3D9"/>
    <dbReference type="GeneID" id="20324307"/>
    <dbReference type="KEGG" id="ovi:T265_10139"/>
    <dbReference type="CTD" id="20324307"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="17156" checksum="A7CC68F1825BD11B" modified="2014-10-01" version="1">MSSATTDPIYTPFFGVIGAVSAVVFCGEWLFSNLRGFLALGAAYGTAKAGAGICSMGVMRPELIIKSIIPVVMAGIVGIYGLVVAVLIVQQDANMKKMDKSLYQLGAGLSVGLSGLGAGFAIGIVGDAGVRGTAQQARLFVGMVLILIFAEVLGLYGLIVALMFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3H6</accession>
    <name>A0A074Z3H6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596955">
        <property type="protein sequence ID" value="KER21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174656.1">
        <property type="nucleotide sequence ID" value="XM_009176392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3H6"/>
    <dbReference type="GeneID" id="20324284"/>
    <dbReference type="KEGG" id="ovi:T265_10116"/>
    <dbReference type="CTD" id="20324284"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703881" description="Peptidase C13 family protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26789" checksum="F512A2D2AE0CF12A" modified="2014-10-01" version="1">MNMLSRCSLLIAFLFCIDHVACLEAIGVHKWSSIFNNNPSKNWVVLVAGSNTWENYRHQADVYHAYRVVRANKVPAENVITFAYDDIANNPKNPFKGKVFHEYEHEDVYNGVVIDYRGKDVTRDNFVKVLKADKQLEANNKKVLKSPYNSFTDSRIDTQDRGYCPSLPGRFCSFRGPNDNVFIFFSGHGATSVIAFQEEYMYAMELNDTLAYMYSKNVQQFGAVCGGLLLWLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4A5</accession>
    <name>A0A074Z4A5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174369.1">
        <property type="nucleotide sequence ID" value="XM_009176105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4A5"/>
    <dbReference type="GeneID" id="20324061"/>
    <dbReference type="KEGG" id="ovi:T265_09893"/>
    <dbReference type="CTD" id="20324061"/>
    <dbReference type="OrthoDB" id="10564122at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10951" checksum="5EB98CDDE5D9C8CE" modified="2014-10-01" version="1">MSALDRKGVTAERLSLRSYTVHRVIASTQHRAGREELCEADGLLACEVHAPTSEIYEVSYTVHRVIASTQHRAGREELCEADGLLACEVHAPTSEIYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4K0</accession>
    <name>A0A074Z4K0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_15314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL597056">
        <property type="protein sequence ID" value="KER20452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175798.1">
        <property type="nucleotide sequence ID" value="XM_009177534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4K0"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20329479"/>
    <dbReference type="KEGG" id="ovi:T265_15314"/>
    <dbReference type="CTD" id="20329479"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703896" description="Hemoglobinase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="46058" checksum="3F0D702E9002ED2B" modified="2014-10-01" version="1" fragment="single">MNVQSSRDMMRRCSILLMFLFCIRQAACLDAISFQNWSSLFNNQPSKNWVVLAAGSNTWENYRHQADVFHAYQLVRKYNVPPENIITFAYDDIANNPKNPFKGKVFHHYDHEDVYNGVVIDYREKDVTRDNFVKVLKGDQKLEANKKKVLKSGPDDNVFIFFSGHGAISHIGFLEEYLYAMELNDTLAYMHSKKKFNKLVLYMEACYSGSMFKDVLPSNMGIYATTSAKEDEKSHAIFCFDPRIRVCLANDYSHAWITDSEQNNIKKRTLEEQYEAVRRKTGLSHVMKYGEMVIILGIRCTSMTNDIADCGTVSELIFIVQQDLSTLAPKQLNVKLRSLGPRGIPAHNSSNRVVQSRIQSRNHHPVCPQRLLLTGTHHVVRFYQNKLNSNWSVSSFAIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z519</accession>
    <name>A0A074Z519_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601648">
        <property type="protein sequence ID" value="KER18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177838.1">
        <property type="nucleotide sequence ID" value="XM_009179574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z519"/>
    <dbReference type="STRING" id="6198.A0A074Z519"/>
    <dbReference type="GeneID" id="20330238"/>
    <dbReference type="KEGG" id="ovi:T265_16073"/>
    <dbReference type="CTD" id="20330238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="15992" checksum="E5BEA06838599609" modified="2014-10-01" version="1" fragment="single">CPPDAKLQWSSTLIDCFVRWLLVTPCVTSKPHHSSIQRDPITTGSPKATARQTSSPGSSGNILLGTLLCSVQTEDEEALSSLSFSASLWRPSLASLNAMIEVGPGPLHAVLYMLYGEQLADEVDFDCYHWVDCVSEYYTLCKNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5S5</accession>
    <name>A0A074Z5S5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596900">
        <property type="protein sequence ID" value="KER22423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173846.1">
        <property type="nucleotide sequence ID" value="XM_009175582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5S5"/>
    <dbReference type="STRING" id="6198.A0A074Z5S5"/>
    <dbReference type="GeneID" id="20323669"/>
    <dbReference type="KEGG" id="ovi:T265_09500"/>
    <dbReference type="CTD" id="20323669"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46463" checksum="D165030D6C3FD8DE" modified="2014-10-01" version="1">MKVERLPIQHWLSVNDQGSIASYKVGDLNVRPVSCAPLLFDVIMGDEDVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMGTASASSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMYPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5X0</accession>
    <name>A0A074Z5X0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_10628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="EMBL" id="KL597008">
        <property type="protein sequence ID" value="KER20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175316.1">
        <property type="nucleotide sequence ID" value="XM_009177052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5X0"/>
    <dbReference type="STRING" id="6198.A0A074Z5X0"/>
    <dbReference type="GeneID" id="20324796"/>
    <dbReference type="KEGG" id="ovi:T265_10628"/>
    <dbReference type="CTD" id="20324796"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="255" mass="28279" checksum="610C43E8BBC29493" modified="2014-10-01" version="1">MTGRFLVRGQPLNLGFSCPGLGNLAVSQPSCFLRYVSPDLVPVYKEKILPLADVILPNQFEAELLTGCPITDEASALECIRQLHSKYHVPTVILTSSSIRYSSNEHPDAKDRMLGYASRCINSGPHTGDLNSVRPTDSESILNGRDTYEQLRLVIPVLDCEFRGTGDLFSALTLARIECGLKSQLKSSFANTFELVLRSMQAVLRRTLDESKNPKGMTRPDSPNWAARELKLVQSIDDIRNPPANGQYVERIPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6C7</accession>
    <name>A0A074Z6C7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL596993">
        <property type="protein sequence ID" value="KER21112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175139.1">
        <property type="nucleotide sequence ID" value="XM_009176875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6C7"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20324660"/>
    <dbReference type="KEGG" id="ovi:T265_10492"/>
    <dbReference type="CTD" id="20324660"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703939" description="Hemoglobinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="436" mass="50439" checksum="10CF566917A69CD2" modified="2014-10-01" version="1">MRRFPLLIAFLFCTDRVACFEAAGVHNLSSIFNNQPSKNWVVLVAGTNTWESYRHQANVYHAYHILRANKIPAENIITIAYDDIANNPKNPFKGKVFHDYEHKDVYKGVVIDYRGKDVKPYIFTMVMTGDKRLEKEGKKVLKSGHDENVFIYYTGHGFRNYITFPEGDLTAAQLNDILLHLYKMKKYNKLVFYMDACYSGSMFMDLFPPNVGIYVTTSANEKEESYGVFCTDKQIGVCLATEYSYAWITDSEHSDLKKRTLEQQYQEVKKRTKASHVMKYGEMAMGDLPVGKFQGHYDALMHQNDVAKAAKVVDRKLSSHMHLFSISRRLMEAATEEEHETAWRRLHHALQLRHVVKEKFGDIVRDVMIQHKPMVKRLSKTDKLICFKAVFDQFQTYCFTIQQVPWLAQLSVQLVELCEVGYEDQAIINSVHSVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6H0</accession>
    <name>A0A074Z6H0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173488.1">
        <property type="nucleotide sequence ID" value="XM_009175224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6H0"/>
    <dbReference type="GeneID" id="20323390"/>
    <dbReference type="KEGG" id="ovi:T265_09211"/>
    <dbReference type="CTD" id="20323390"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="497" mass="55513" checksum="987D5291C382F601" modified="2014-10-01" version="1">MFRFRAQPATLSIGSFKFIPVYVTATSGLASETKAQLCFPRSTKKRITDTNIINSSGPDLNGDTVGWNNDNLKTEEYATYSDKSRFQMGTIKLHKKPERVGAGQNRMNVDVAPVHKVPENSSATQDRLCPFWDSSDKCNPRVSIKLLFYLKPNWTDFDKCTHLNSKLVIKGDSTESLVYNILQYTAISRILCQLKHEASLGCELTDQKVRVSSPIPTSHLVLSRFWQPGRIPAIMNPSGVVSLGHREVATATFFKITVKPHQSLIIANASSPIEVTSSVRRQLRTDDVTSTGVETFPIQLPNLANRPTTHQRTQAPYIPKYCRCFCLVAPVGMHENCQTRRTDQRPISAPRLPIFQNTADETTHWVAENSSTAHDRFRLFRGSSAGQFDCKRFITTTNPQLLTTTLPSNAVMSPRLVMKRLQSNCPAQRTSQQPPFLNTCGNRSTVVPFQSLIAMPPEGSTWAGILPECPSLDKESQKVEVGFEPRTFGLINSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z794</accession>
    <name>A0A074Z794_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596867">
        <property type="protein sequence ID" value="KER23056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173212.1">
        <property type="nucleotide sequence ID" value="XM_009174948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z794"/>
    <dbReference type="STRING" id="6198.A0A074Z794"/>
    <dbReference type="GeneID" id="20323177"/>
    <dbReference type="KEGG" id="ovi:T265_08998"/>
    <dbReference type="CTD" id="20323177"/>
    <dbReference type="OrthoDB" id="10255247at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="516" mass="58966" checksum="0F354444CAB9D420" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7J1</accession>
    <name>A0A074Z7J1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <dbReference type="EMBL" id="KL597307">
        <property type="protein sequence ID" value="KER19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177099.1">
        <property type="nucleotide sequence ID" value="XM_009178835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7J1"/>
    <dbReference type="STRING" id="6198.A0A074Z7J1"/>
    <dbReference type="GeneID" id="20326142"/>
    <dbReference type="KEGG" id="ovi:T265_11974"/>
    <dbReference type="CTD" id="20326142"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28382" checksum="6029549CCD03A95A" modified="2014-10-01" version="1">MENWIVRNWDDMILLYDYIFGPKKMNVDPKHSKILLTEPPLNPLKNREKMVEVMFEKYGFNAVYIAIQATLALYAQVIIVTMNNMTSLFNTDISLPHNHDLSEGLMVKIRIKMDIVRTTIILRCSHLQTHSDNPLLVLVTLFSEGARCTTENSLSNNLIMNSPAPTHASYGHDTEILEYLKTSQFHCWDRPSFAAIQQNTYPAAATSALPDVCSWKLEESDRTLSSISANGIERTNKMPLVVLLASVCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7V8</accession>
    <name>A0A074Z7V8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173082.1">
        <property type="nucleotide sequence ID" value="XM_009174818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7V8"/>
    <dbReference type="GeneID" id="20323069"/>
    <dbReference type="KEGG" id="ovi:T265_08890"/>
    <dbReference type="CTD" id="20323069"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18776" checksum="5E35680A1A658114" modified="2014-10-01" version="1">MNELLLIIYGTQDNTWGYALIVSGLILTILVVAYNPLRFLRVVINGFGTSDWTVPVVWVAIITVVVPGICILLIVWWIYDYVRDTERWYDVTWTSATSTLIEWLVVLTAIVIINLVVVRVKRDLYVKTKRFGADPYDPETYTKESVVVGGNIWAVGDSNYSVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z871</accession>
    <name>A0A074Z871_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597208">
        <property type="protein sequence ID" value="KER19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176813.1">
        <property type="nucleotide sequence ID" value="XM_009178549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z871"/>
    <dbReference type="GeneID" id="20329706"/>
    <dbReference type="KEGG" id="ovi:T265_15541"/>
    <dbReference type="CTD" id="20329706"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="22661" checksum="F84E214F7706926E" modified="2014-10-01" version="1" fragment="single">MCVSLLSSQFHLINIREGITWNPVESAFNMIWRHFEVCREMLPEKTQDIVCGPNCSAPIIEFDLTAAPRTNSRKCTHDASVQCGKAEPNFGPEFDTQADRQQAMGRTKTAMMGPGCDPTVFFASLQQALDGALLQLDGVLRHLLLSDHSVEGVQPSPRARLRLATATGLLNQHEFVYYSEACVIQMTNTENCLLALNEFTEPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9D6</accession>
    <name>A0A074Z9D6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_09689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174108.1">
        <property type="nucleotide sequence ID" value="XM_009175844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9D6"/>
    <dbReference type="STRING" id="6198.A0A074Z9D6"/>
    <dbReference type="GeneID" id="20323857"/>
    <dbReference type="KEGG" id="ovi:T265_09689"/>
    <dbReference type="CTD" id="20323857"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="453"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER22157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1279" mass="143989" checksum="1E5337AD419A6178" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F0</accession>
    <name>A0A074Z9F0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597123">
        <property type="protein sequence ID" value="KER19875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176381.1">
        <property type="nucleotide sequence ID" value="XM_009178117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9F0"/>
    <dbReference type="GeneID" id="20325627"/>
    <dbReference type="KEGG" id="ovi:T265_11459"/>
    <dbReference type="CTD" id="20325627"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8015" checksum="5505C12AB121F676" modified="2014-10-01" version="1">MLLQKRNTAFLSSLPVALNSAAETIFDVYSPVSTVFPGHFLAGTDLRLCAVIPGDNFPKRAKELLVLYTALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F3</accession>
    <name>A0A074Z9F3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172365.1">
        <property type="nucleotide sequence ID" value="XM_009174101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9F3"/>
    <dbReference type="STRING" id="6198.A0A074Z9F3"/>
    <dbReference type="GeneID" id="20322512"/>
    <dbReference type="KEGG" id="ovi:T265_08333"/>
    <dbReference type="CTD" id="20322512"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="19047" checksum="1228AC8F9EED7293" modified="2014-10-01" version="1">MKETTHKVAENSSTAHDRFRPSCGSSGRRIPRVSFNLMIYLNPNWTVFEKYTHLQIDLIHFIRYAEFSTIDILHHELTRDAPELPRLNGLMLVRGQGYTQPMKSAGAKLESSASPIWLWLRDLTTSGREKHRLNKSGVDTDDSLYLQINAENNAAVFDDITNDDGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9U3</accession>
    <name>A0A074Z9U3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596827">
        <property type="protein sequence ID" value="KER24006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172261.1">
        <property type="nucleotide sequence ID" value="XM_009173997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9U3"/>
    <dbReference type="GeneID" id="20322429"/>
    <dbReference type="KEGG" id="ovi:T265_08250"/>
    <dbReference type="CTD" id="20322429"/>
    <dbReference type="OrthoDB" id="10521041at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="255" mass="28447" checksum="2430C05B26EBBB4C" modified="2014-10-01" version="1">MSHRQSRTVHFQCPCRDLNPGHLICEASVYPLLHEPTLDASEFSRLNMRTCSHLSDEISVPDPSNDDPVTVPVLTIDRSVRLDRLPHVPGVLTTRFLRPSGCCPSVNAHALIRLLKTLRPPTTDFSLVGAQQRLKREAAWCSTFSRLETSKPRDSAGFQTSKLYQSQDWEVPEIQLFENSTNGLGSRMQAGDHSIKCTVEWRRVADNSSTAHDQCHPSWGSSGRGSPQVLLVTKLHEISEIHSFLRGSNIVATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBA4</accession>
    <name>A0A074ZBA4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_14765"/>
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    <dbReference type="OrthoDB" id="1870062at2759"/>
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        <property type="entry name" value="BRD10"/>
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        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
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    </dbReference>
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        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KIAA2026_hel"/>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1488" mass="165412" checksum="4BB7E61B6A8F27A2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
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        <lineage>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
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                <person name="Maleewong W."/>
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                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9992" checksum="74C53E2646AD00EB" modified="2014-10-01" version="1">MHVQESVEIALTTQSAQYVESATRQSVTIIRIDSRTSVFNTDVSLPYNHNFIESLIVKKMKVDGKVTQCDMTTIIPRCLTSGHSYRQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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    <name>A0A074ZD10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">T265_08582</name>
    </gene>
    <organism evidence="11 12">
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        <lineage>
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    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="OrthoDB" id="10059618at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
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        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2010"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="182"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="710"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1525"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1764"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1968"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2048" mass="234334" checksum="FAA4B66B4C5DB0A3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD18</accession>
    <name>A0A074ZD18_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171143.1">
        <property type="nucleotide sequence ID" value="XM_009172879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD18"/>
    <dbReference type="GeneID" id="20321554"/>
    <dbReference type="KEGG" id="ovi:T265_07375"/>
    <dbReference type="CTD" id="20321554"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13064" checksum="12D0B3BFE828A0F4" modified="2014-10-01" version="1">MFGTDWEVIVSEEFGRQSVDILLGTVSPLTQKLRQANTCLSGLQNVARKLAIIFTDNIQASILAHQVVMERVVDRDTRDREARSTKPVKAVRLHSLDFLIGPIDAVTSVGWSSTGRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFE2</accession>
    <name>A0A074ZFE2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596928">
        <property type="protein sequence ID" value="KER21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174292.1">
        <property type="nucleotide sequence ID" value="XM_009176028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFE2"/>
    <dbReference type="STRING" id="6198.A0A074ZFE2"/>
    <dbReference type="GeneID" id="20329131"/>
    <dbReference type="KEGG" id="ovi:T265_14965"/>
    <dbReference type="CTD" id="20329131"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47661" checksum="E49DFCDCF4AFEC65" modified="2014-10-01" version="1" fragment="single">MSSLLNAPIFSTHFIDFVTDSRSMTVLRVITSTKGDEESTKLEEVPELKGGARLKKSIGLLSSTTIVVGSVIGSGIFVSPQGILAMTNSFGASIIVWIACGLFSLVGAYCYAELGTMMPRSGADYSYVHEAFGPFFGFIRLWIDVSVAQPVAAAIISMVFANYLLKPAFPTCAESPPAAVRLLACVCVITVGFINCMSVRWSTRTQNIFTFAKVAALVMIIITGFVQIGRGRTEEFQDPFEGSNWNPGSLTVAFYNGLFAYSGWNSLNCMIEEMKNPRRDLPIAIIVSCLIITIIYTMANVAYATVLTIPEILNSDAVAVSFAIRIYGPAWWIMPIFVALSTFGGVNGSVMTTSRMFFVASQQNQMPKLLSFLQTSSLTPVPAIVFMCGVTIVYVGIGEISSLMNYLGFVKWLAVGISVLIVIIFRFTRRTMERPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFK0</accession>
    <name>A0A074ZFK0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171858.1">
        <property type="nucleotide sequence ID" value="XM_009173594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFK0"/>
    <dbReference type="STRING" id="6198.A0A074ZFK0"/>
    <dbReference type="GeneID" id="20328598"/>
    <dbReference type="KEGG" id="ovi:T265_14432"/>
    <dbReference type="CTD" id="20328598"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047326">
        <property type="term" value="F:inositol-1,3,4,6-tetrakisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="400" mass="45218" checksum="A8C6F0C024EA6626" modified="2014-10-01" version="1" fragment="single">EPINVVDKFVYLGSCISFGGLAGDEIISRFGKAREAFANLRQLWRRRDQARFVSVSPPLISMDVRCCFTPVDTNLPPETTNPLPGNLQVYTNQVGGHGMFGNKGRMLHSPALGAVYKPVQKYPKGPHEVDFYRLLFNPDCEDSVFLQLRPFLPKYRGLYHHPSSKALYLGMSDVLEQLKHPSICDIKIGRNTYAPDASAKKIAVEKAKYKWQAELGFLISAIRVVDSSDDLRPVYIDRTFGRSLSPSTVYDHGIRVFLGPNMKRSRSLARRFVTQLNKLSEWFEQQDKLSFYASSLLLAYDSHQDDLHSEPTLTSSSFSDAGEEHDNDELVVTYLIDFARWRPLESGAGSRDENFLYGLRNLIQLFQRVSAETAPLQLSVQQFSFRNSKDLISGLPPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFU3</accession>
    <name>A0A074ZFU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_09728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596919">
        <property type="protein sequence ID" value="KER22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174155.1">
        <property type="nucleotide sequence ID" value="XM_009175891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFU3"/>
    <dbReference type="STRING" id="6198.A0A074ZFU3"/>
    <dbReference type="GeneID" id="20323896"/>
    <dbReference type="KEGG" id="ovi:T265_09728"/>
    <dbReference type="CTD" id="20323896"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="567"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="445"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="631" mass="70543" checksum="96815CB5A5B96B4C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFY1</accession>
    <name>A0A074ZFY1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170089.1">
        <property type="nucleotide sequence ID" value="XM_009171825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFY1"/>
    <dbReference type="STRING" id="6198.A0A074ZFY1"/>
    <dbReference type="GeneID" id="20328220"/>
    <dbReference type="KEGG" id="ovi:T265_14054"/>
    <dbReference type="CTD" id="20328220"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052392">
        <property type="entry name" value="Kelch-BTB_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375:SF3">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46375">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704112" description="Kelch repeat protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12180" checksum="21DA94E3CBB965CB" modified="2014-10-01" version="1" fragment="single">MVLRQRLCAAWLLVCSPSLAVGLQAFHHQSSLGVTTLHDILVLALRSVEVFDISGEAWSSIAPMSCARRRLGVTAFYGAIYAIGGENRSGILSSVEKYKPSTGLWMSVQSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGA0</accession>
    <name>A0A074ZGA0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169967.1">
        <property type="nucleotide sequence ID" value="XM_009171703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGA0"/>
    <dbReference type="STRING" id="6198.A0A074ZGA0"/>
    <dbReference type="GeneID" id="20328199"/>
    <dbReference type="KEGG" id="ovi:T265_14033"/>
    <dbReference type="CTD" id="20328199"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="517" mass="57417" checksum="686C68F85C589B2A" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGM9</accession>
    <name>A0A074ZGM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171431.1">
        <property type="nucleotide sequence ID" value="XM_009173167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGM9"/>
    <dbReference type="GeneID" id="20321782"/>
    <dbReference type="KEGG" id="ovi:T265_07603"/>
    <dbReference type="CTD" id="20321782"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19418" checksum="533BF8AE63FEF3C2" modified="2014-10-01" version="1">MLRFMDNPVTVVKGRRRDTQFRGETEIDTGSHTDVGSRTISLLLKDRCLSLVMIKSRRDGTWWVQRHVESKRSVERLQSAPLQKVRLIRSAKGDSRGYGGPRREGENRSRAAGFGPIVHRNRVQGWCQRGQSGLVGLHVAAFLAPESSSAFERLSNLASSSPIKAEQWQWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGS1</accession>
    <name>A0A074ZGS1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173796.1">
        <property type="nucleotide sequence ID" value="XM_009175532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGS1"/>
    <dbReference type="GeneID" id="20323626"/>
    <dbReference type="KEGG" id="ovi:T265_09457"/>
    <dbReference type="CTD" id="20323626"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19657" checksum="3F08A1F82EAE3402" modified="2014-10-01" version="1">MRAEILPVCPHLDRRSRDAVIKETERNPILQGNRTLSAQHSQHTQTRARAGSRKSTALHKSTDNYGTHVAAIPRSKHVPAVQTLTKELSFDLIPFCIVFFYTCCNPPRLTILTSLLVNIPSELAITNSASIPAGETNHKVAENSSAVHDRFRPSTLDSSGRRSPQVSVNLMFYMNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGY3</accession>
    <name>A0A074ZGY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171302.1">
        <property type="nucleotide sequence ID" value="XM_009173038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGY3"/>
    <dbReference type="STRING" id="6198.A0A074ZGY3"/>
    <dbReference type="GeneID" id="20321680"/>
    <dbReference type="KEGG" id="ovi:T265_07501"/>
    <dbReference type="CTD" id="20321680"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="396"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="936" mass="105694" checksum="69E480C6A9AE168B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHN3</accession>
    <name>A0A074ZHN3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171018.1">
        <property type="nucleotide sequence ID" value="XM_009172754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHN3"/>
    <dbReference type="STRING" id="6198.A0A074ZHN3"/>
    <dbReference type="GeneID" id="20321455"/>
    <dbReference type="KEGG" id="ovi:T265_07276"/>
    <dbReference type="CTD" id="20321455"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="37399" checksum="10C68FE46F8FDFAE" modified="2014-10-01" version="1">MKEIGVARLPGWGPRDPHCAWLETLQDMAANRYVLYLHPTPPIRTPPHKRDVAIPPFEVKYQDHLPASFRTQVRQRLGIGSVVQLTPRNALSCTDECPSLVDSLARRELGEAVNILCVRASKVASKLPLLQSLKSDIPYAITADLFAGPLEDVSTSTQVYTGGQSLIWAIEILACLTLASYTEDTYGSVQRSLGRILSLFADGLEVVERHLRLVGLLTKDVGSNVYPMPEDELSNSPGLSGELPASDSPVSARLTPYMNPVAACKAEDICNLSYYRLASDPTLPWRVYATLTWAATNCLRQFGDHLDSIQMSQKARQRLRLAAATRLASGQLNGSIQTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHN6</accession>
    <name>A0A074ZHN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171021.1">
        <property type="nucleotide sequence ID" value="XM_009172757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHN6"/>
    <dbReference type="GeneID" id="20321458"/>
    <dbReference type="KEGG" id="ovi:T265_07279"/>
    <dbReference type="CTD" id="20321458"/>
    <dbReference type="OrthoDB" id="10480867at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="24411" checksum="6453ECAF207C19AC" modified="2014-10-01" version="1">MARYAFQDGVHVGLPALDWRGSRKWLLIYPSGQDISVNANISDNDDEYRKHTVLPIITRKLFARCERHFHQKETEYRTVRNTTPINTKCLEGYRGGTQDCIACTDVHSRATCLEAVSTKQRRSMKQRPTVSPMKSHPSWHQNKQVEFIHTLGRQASRSAVVSSSHSSVQRHEITVTVTSRIIMHGPWSSSNLCYSKLLKYGYWANRFIAEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHX0</accession>
    <name>A0A074ZHX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175108.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_09117"/>
    <dbReference type="CTD" id="20323296"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell size"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="579"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER22885.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1495" mass="163575" checksum="4062AA547976E337" modified="2014-10-01" version="1"> </sequence>
</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="KER27088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10639" checksum="E0F85D55C38229C6" modified="2014-10-01" version="1">MSPLNPNYTKFDLYTQLRTNLVLTGDSFGIQLVPDVVPERNRQDASTIVIKVGGWIPGFGGRASQETRRNDSKLRTAEVGVFRVLEASGFATDGQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">T265_05520</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OrthoDB" id="73653at2759"/>
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    </dbReference>
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            <dbReference type="EMBL" id="KER27413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="22517" checksum="E70FD9027E959925" modified="2014-10-01" version="1">MGKVISCQGCHVLLQSHALFSAREYCWGVEINYVHFLHIRSAVTSFRCLATIPPEGSTSAGILPGCPSLDKGSRETRIFREYTLICKLLWFFERPTWNPDESLVCDVLRQLNVLHQVASCFSRYDIRYIAIHVYLCNVLLIRLMKIRRQPTTGFALPLRAHQSFSSSLKPEAGSPEHQTCEHVVISTIIFRKCHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL03</accession>
    <name>A0A074ZL03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="769"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="804" mass="85748" checksum="79E7D20C170B1F8B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLE5</accession>
    <name>A0A074ZLE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169649.1">
        <property type="nucleotide sequence ID" value="XM_009171385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLE5"/>
    <dbReference type="GeneID" id="20320366"/>
    <dbReference type="KEGG" id="ovi:T265_06184"/>
    <dbReference type="CTD" id="20320366"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13188" checksum="FD59302710B62050" modified="2014-10-01" version="1">MELEVHAVSPICWLLSNHGIKLITFTSVTDYESKNQYIFLVYCYAAATDNDDIEDDDDDDYRVFTTYPDQKIVSCGVRSLLRSSASAGGTPSGELGFGVARYASRDLCKISSVGPSPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLY3</accession>
    <name>A0A074ZLY3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169484.1">
        <property type="nucleotide sequence ID" value="XM_009171220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLY3"/>
    <dbReference type="GeneID" id="20320232"/>
    <dbReference type="KEGG" id="ovi:T265_06050"/>
    <dbReference type="CTD" id="20320232"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="499" mass="55796" checksum="2B78F3AAFF0957A6" modified="2014-10-01" version="1">MTSLQSWHQLLAGLRNGPQSLRGHFSLPQGYHILETHYIDDCQLLLTRLLKILGPPTTGFAFLGAPQVDAVTEFPATLYSTCFSDFQLRFILDDIKPSMSYSSKRLKNLVRHLFGTWVTYHLKEVSGLRYCQAAQPQALEMQRSGSNYELPERSSAGIGFELRTSEITRARIPRRSHTPNNPPPPHTRVNRSDTKRFTSNRRYFNCPLRIPCPTTCCFVSLRKPTKSVVKMKDTHGANLHAGSSNVGTIDACQFVARAYCPVSLVAQKPVVNRSMTGTYRLGLGKAELLVRRVIEELVPFDLPTHPRSSFLALVISTCRQLEHHQRCISLVVLEFKPQSPAVRGARVYRSAAAPFRCLAAIPPEGSTRAGILPGCPSLDRGSREAEVGFEPRTFRSVNSCYNHLSHLARVATHRRKVLRAMQTSNLLCALHIHSHTAGNRVNIPDPVHGEWYILVSHRFASSTVTQPISETSAIVLGRVLLSLFRVRHPLEPGYQEIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMM8</accession>
    <name>A0A074ZMM8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171646.1">
        <property type="nucleotide sequence ID" value="XM_009173382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMM8"/>
    <dbReference type="GeneID" id="20328543"/>
    <dbReference type="KEGG" id="ovi:T265_14377"/>
    <dbReference type="CTD" id="20328543"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="14412" checksum="A8349750084B4AA5" modified="2014-10-01" version="1" fragment="single">QLNVLQQATPCFRRYDIPDIATHAYICNVLLIRLLKTSQTIYSVAVQVSFDNRAKSEAVYLTIFVTLSFIWIYLPRAEKLSSISVVKIMANRKMWCKVSSPDGSLMMPDVLIIIGLQGDSQKVSSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNL4</accession>
    <name>A0A074ZNL4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine deaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167597.1">
        <property type="nucleotide sequence ID" value="XM_009169333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNL4"/>
    <dbReference type="STRING" id="6198.A0A074ZNL4"/>
    <dbReference type="GeneID" id="20327702"/>
    <dbReference type="KEGG" id="ovi:T265_13535"/>
    <dbReference type="CTD" id="20327702"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="67"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="458" mass="49572" checksum="AC1F120E55163E59" modified="2014-10-01" version="1">MDHVTENNCHSPYVFDCEEKQADCKHRLITDIPIPDANDPDVFEPDCDLHNPVAVTYRDVSAAYYRIRDGIIRTPCKKSQLSKIYNMNIFLKLELQQVTGSFKERGARNFLLQLTPEQAKRGVIASSAGNHGQALAYHGKNLNIPVTIVMPVFAPLMKVENCLSHGANVVLKGTDMSQAKPYALKVAKVNDIRYVNGYDHPQVLAGQGSVALEIMEQVPTVDAILVPVGGGGLLAGIAVAVKGINPKVQVIGVESDQCAGFGRSIQAGEVTYTPCAPTIADGLAVPLVGVNSLHTCLGLVDKMITVEESHIHRAIIRLLEVEKCVAEGAGATALAAILAGYLPELEGKTVVPIISGGNIDTTVLGRVIDRGLTLEGRLCRFLVVVSDRPGGIAEMCCMLRDLGVSIKDIFHERAWLKSSIFNVQLRVVCETRDINHAAQLERALRKKYAEVLWGSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP25</accession>
    <name>A0A074ZP25_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009172923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP25"/>
    <dbReference type="STRING" id="6198.A0A074ZP25"/>
    <dbReference type="GeneID" id="20321592"/>
    <dbReference type="KEGG" id="ovi:T265_07413"/>
    <dbReference type="CTD" id="20321592"/>
    <dbReference type="OrthoDB" id="6279146at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="372" mass="43043" checksum="2E03D2E3CA76AB80" modified="2014-10-01" version="1">MYVNHLRSFVRNLRAQPTRLHTRASQISPVLQYCDFVFVRVDQVKKPLQPPYVGPYRVISCRPKYFVIDKGGVQDTVSVDRLKVAHVDPTLFSPINQSQRLSTPPLHTNDIAIPKPDNLQPADHTRSDSKALLVATVKMGDSAVEKRVMLDIILSFIWIASDKLRTAEHRTPSAHRTDDDCPRADPPDYRSKETHPAVPQNCLVCGKSFRHLSSAKRHQELHAENASAQCSLCKSSFRNERYLRQHMRRLHSPGEKKPRRTSSKRVPESELRDNPCPKCGKCFLTWKTLSQHLKWSHDEEAHQQCEECGAFFQRKSNLDRHLSTVHEKQRHYMCDQCGQTFARLDILRRHVAQMHTNHPDDKRLINEKPMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQG4</accession>
    <name>A0A074ZQG4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170678.1">
        <property type="nucleotide sequence ID" value="XM_009172414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQG4"/>
    <dbReference type="STRING" id="6198.A0A074ZQG4"/>
    <dbReference type="GeneID" id="20328351"/>
    <dbReference type="KEGG" id="ovi:T265_14185"/>
    <dbReference type="CTD" id="20328351"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="362"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="448"/>
            <end position="452"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="721" mass="82274" checksum="A01ABCAEEA9C45D8" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQH4</accession>
    <name>A0A074ZQH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166906.1">
        <property type="nucleotide sequence ID" value="XM_009168642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQH4"/>
    <dbReference type="STRING" id="6198.A0A074ZQH4"/>
    <dbReference type="GeneID" id="20318210"/>
    <dbReference type="KEGG" id="ovi:T265_04024"/>
    <dbReference type="CTD" id="20318210"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="582" mass="66752" checksum="6D370B3063225105" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQY7</accession>
    <name>A0A074ZQY7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166686.1">
        <property type="nucleotide sequence ID" value="XM_009168422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQY7"/>
    <dbReference type="GeneID" id="20318028"/>
    <dbReference type="KEGG" id="ovi:T265_03841"/>
    <dbReference type="CTD" id="20318028"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="26825" checksum="477FC2248F9C40BA" modified="2014-10-01" version="1">MPHEGSTRAGILPGCPSLDRERRDAEVGFETRRFRTITFIIDSMTLVFNTGASLPYNHDFFEGLTVKKRVKDGDRVILTVSGWRHYNIWLPTDVSGVLVVSFCPECLSECLDVFSNKSWLYGSETSVLNTDVMLSMMMMMMMMVKHTQHMCQPTQLLVLNTYFNGGTRRTTENTLSNCRVTDTPTLTLTSYCSGTTIVEHLKTPQFRRRNRPSLTVIQRNIPHCSSIHTSIEMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSS6</accession>
    <name>A0A074ZSS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603430">
        <property type="protein sequence ID" value="KER18324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177929.1">
        <property type="nucleotide sequence ID" value="XM_009179665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSS6"/>
    <dbReference type="GeneID" id="20330301"/>
    <dbReference type="KEGG" id="ovi:T265_16136"/>
    <dbReference type="CTD" id="20330301"/>
    <dbReference type="OrthoDB" id="6288376at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="10462" checksum="097E064A0D59EFB1" modified="2014-10-01" version="1" fragment="single">AESVFRDVAARLDLHPASDISASTLLTAAGGSDGPRLSTLTSSNGTLPESPTHSTTVNPYVSLDARWDGLFPPRPPRPEEIVSGEDDQGTLQTSAFPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT20</accession>
    <name>A0A074ZT20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165695.1">
        <property type="nucleotide sequence ID" value="XM_009167431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT20"/>
    <dbReference type="GeneID" id="20317229"/>
    <dbReference type="KEGG" id="ovi:T265_03042"/>
    <dbReference type="CTD" id="20317229"/>
    <dbReference type="OrthoDB" id="10423095at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="10036" checksum="FE0B8809D4C21827" modified="2014-10-01" version="1">MYILAIESHTRPSMTDTMCLKKLHTTLLKTPTADYRFRPSWGSPARCCLRVSVNLMFHLNPNWTDFDKHTHSQINLVFTRYSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT30</accession>
    <name>A0A074ZT30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167250.1">
        <property type="nucleotide sequence ID" value="XM_009168986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT30"/>
    <dbReference type="GeneID" id="20318469"/>
    <dbReference type="KEGG" id="ovi:T265_04287"/>
    <dbReference type="CTD" id="20318469"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12563" checksum="DD412D627C0D1EEF" modified="2014-10-01" version="1">MCASSDRVGTFLFYGHQTGDREKKRQTLQSFPASYDADLFEQSDQLFRPYLIAKPTLGDAINLGVHMLLVCNCYVGPVPVSRRVHAMVVDTSNPKRSSGNLCLSNLMDHEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU78</accession>
    <name>A0A074ZU78_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169293.1">
        <property type="nucleotide sequence ID" value="XM_009171029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU78"/>
    <dbReference type="GeneID" id="20328060"/>
    <dbReference type="KEGG" id="ovi:T265_13893"/>
    <dbReference type="CTD" id="20328060"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10229" checksum="8276DD3E9DF8C7B9" modified="2014-10-01" version="1" fragment="single">MKNPSELSGTTGLYLQHPFHGPNWMPRQRLLAICARAPRTRRAQPRQCLGYTMATLDRQYKANGWQTPPEANHVKPVEFEHAEVLQMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUZ8</accession>
    <name>A0A074ZUZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165225.1">
        <property type="nucleotide sequence ID" value="XM_009166961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZUZ8"/>
    <dbReference type="GeneID" id="20316847"/>
    <dbReference type="KEGG" id="ovi:T265_02659"/>
    <dbReference type="CTD" id="20316847"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44341" checksum="8A4EE16DB42A457E" modified="2014-10-01" version="1">MPTFRKSEYSFDCSHVDGTDEFRNAARSPTAARTTTTTKPCLVKIARNCPIQVGKVNHTKLTAITNYILERYWSCRKVIHEWLIFLVACFFRNENVRSTQSRLIVLGVGQMRTGTSSLKRALEILYNKPCYHMMDVAFLHKQRHISKWLDALEQLRESKKKTPDHDKLLMKEFWQPIYDQYVGAVDYPSCVFYKYLMKVYPEAKCILTLRNPDDWVKSCRATTMCENMLRQPSVGDLIYAHFRGIPDLSTLHHRMFEAALGPTFATMSDDQLRDAYCEWNQQVISEIPPDRLLLFDPQQGWEPLCQFLGVPRPPVTVPFPHLNKREEMRLRLEDFYWRGRFCNYLVFTSLVLFVFGVLCPLSAWKCFYAVKTFLYSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVQ9</accession>
    <name>A0A074ZVQ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168802.1">
        <property type="nucleotide sequence ID" value="XM_009170538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVQ9"/>
    <dbReference type="GeneID" id="20327957"/>
    <dbReference type="KEGG" id="ovi:T265_13790"/>
    <dbReference type="CTD" id="20327957"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705531" evidence="2">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="33970" checksum="B017B9F20034E4E8" modified="2014-10-01" version="1">MFSMLSIFAAIVSQSTGAISPKHSYVATHLFMGIAQCFSYTCMLLADQSLSSEYDLCESWWVSMGGCTLLSYNAYLYLLDSFSGYSVASAKMNRDSHRPAQRGFQLLIYRKIILTEASKGILKECTTVLIPVSIWVRIFPKDTWLHTRVRVSQVDKDTHQSVDDKSRHRCRQDDATWLLPPNWSSLRCEVLVGFRVETSRLLVVFCAREKYLHLQTLKKLCCTLLPHCCTGGQPEGTNYPSTGTRFSHRLKSSNASAPRGNKTPESIKRHLFSRFPPYPIETYVPKETSYAVRSGLLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVR8</accession>
    <name>A0A074ZVR8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_02206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164658.1">
        <property type="nucleotide sequence ID" value="XM_009166394.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZVR8"/>
    <dbReference type="GeneID" id="20316394"/>
    <dbReference type="KEGG" id="ovi:T265_02206"/>
    <dbReference type="CTD" id="20316394"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705366" description="Nephrin" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="467"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="591"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="845"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="946"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1494"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1733"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1757" mass="195670" checksum="AA17ECDCE30B2C88" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVW2</accession>
    <name>A0A074ZVW2_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164686.1">
        <property type="nucleotide sequence ID" value="XM_009166422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVW2"/>
    <dbReference type="GeneID" id="20316422"/>
    <dbReference type="KEGG" id="ovi:T265_02234"/>
    <dbReference type="CTD" id="20316422"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11491" checksum="87E9821E868E7D95" modified="2014-10-01" version="1">MCDSCFLSTAYHPSYTNGNLREIHSFANQFVFHERLNRISLGTIVEISQCIFIKETTHKVTENSSTAPDLFRPCRVSSGETQLNLSLMVFYNWMCCTQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW83</accession>
    <name>A0A074ZW83_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SWIRM domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_03399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166132.1">
        <property type="nucleotide sequence ID" value="XM_009167868.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZW83"/>
    <dbReference type="GeneID" id="20317586"/>
    <dbReference type="KEGG" id="ovi:T265_03399"/>
    <dbReference type="CTD" id="20317586"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="505"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="791"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="794"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="949"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1283"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1325"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1355"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1436"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER30142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1460" mass="156030" checksum="CF7C75C1DCB9E2A1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWA0</accession>
    <name>A0A074ZWA0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31708.1"/>
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        <property type="nucleotide sequence ID" value="XM_009166238.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A074ZWA0"/>
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    <dbReference type="KEGG" id="ovi:T265_02079"/>
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    <dbReference type="Proteomes" id="UP000054324">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="8844" checksum="5917A26608707C3F" modified="2014-10-01" version="1">MSIIQLSEPARIRWHHMIQMADLTTSAMRTSTRISLYRSHSGAATAEKSIPRTIGQEFGTLASPASSRDLIGRMSGPNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWT1</accession>
    <name>A0A074ZWT1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">K+ channel tetramerization domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_02001</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164403.1">
        <property type="nucleotide sequence ID" value="XM_009166139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWT1"/>
    <dbReference type="STRING" id="6198.A0A074ZWT1"/>
    <dbReference type="GeneID" id="20316189"/>
    <dbReference type="KEGG" id="ovi:T265_02001"/>
    <dbReference type="CTD" id="20316189"/>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="15">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="393"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="887"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER31918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="102612" checksum="82D9379927CA1467" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX81</accession>
    <name>A0A074ZX81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164617.1">
        <property type="nucleotide sequence ID" value="XM_009166353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX81"/>
    <dbReference type="STRING" id="6198.A0A074ZX81"/>
    <dbReference type="GeneID" id="20316367"/>
    <dbReference type="KEGG" id="ovi:T265_02179"/>
    <dbReference type="CTD" id="20316367"/>
    <dbReference type="OrthoDB" id="10356082at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="11955" checksum="E48C64B9A7FC322A" modified="2014-10-01" version="1">MLLGTTLKISGKSVKDGRHACRDAMRLAKKNDIQAHAYLYVDPDVDVALAKSIRELKPDLVLMNGPKCTALQSKNAKTTINYPKAVCSCKCNFCSPPRRPMVIWKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY10</accession>
    <name>A0A074ZY10_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168066.1">
        <property type="nucleotide sequence ID" value="XM_009169802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY10"/>
    <dbReference type="GeneID" id="20319116"/>
    <dbReference type="KEGG" id="ovi:T265_04934"/>
    <dbReference type="CTD" id="20319116"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7125" checksum="9DDD06F2997E4A91" modified="2014-10-01" version="1">MYPNSKYGGAIEPTISYHSQWWLRLVNTVLEKDNFSTNSNSVNITFYTDDVAGYVNPVEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYP9</accession>
    <name>A0A074ZYP9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009165286.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZYP9"/>
    <dbReference type="GeneID" id="20315468"/>
    <dbReference type="KEGG" id="ovi:T265_01280"/>
    <dbReference type="CTD" id="20315468"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM1_hnRNPA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12328">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000040">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein A2/B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF16">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="544" mass="60430" checksum="CECF9334AD4F459C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYZ3</accession>
    <name>A0A074ZYZ3_OPIVI</name>
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        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
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    </protein>
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        <name evidence="11" type="ORF">T265_02512</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31187.1"/>
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        <property type="nucleotide sequence ID" value="XM_009166775.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYZ3"/>
    <dbReference type="GeneID" id="20316700"/>
    <dbReference type="KEGG" id="ovi:T265_02512"/>
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    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097681">
        <property type="term" value="P:double-strand break repair via alternative nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec63 N-terminal domain-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="419"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2765" mass="305288" checksum="67269383099412C5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN6</accession>
    <name>A0A074ZZN6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal cation transporter, ZIP family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175638.1">
        <property type="nucleotide sequence ID" value="XM_009177374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN6"/>
    <dbReference type="STRING" id="6198.A0A074ZZN6"/>
    <dbReference type="GeneID" id="20325046"/>
    <dbReference type="KEGG" id="ovi:T265_10878"/>
    <dbReference type="CTD" id="20325046"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704400" description="Metal cation transporter, ZIP family" evidence="6">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45693" checksum="999E98ADF54246B8" modified="2014-10-01" version="1">MKPVQSFRASFIQSLLVLYLPSVALGGEHGVLHGTGDRTPLTGGKLGLAAVMFLYSFLACSLPVLIVNCVDRKEQSAADQETDSLLTKSGCFSRYWTPERRTKIISRSNCLAAGALLSVGFLDVFIDTIECFESALAKVNVTTDFPLASFVTLLGFFLILGVEQITLEFFRTPGTDVPMQHQDGSAIQGAIIRRTTSQSSSISQRTTSLTAVNETVAILPEVLDPRGSLMPEFECLSVESEHQGHHHHHSTIIQSGWIRVLTLLCAISLHSVFEGMALGLTKSYTSLLTLFAALSMHKIIIAISIGINLVSETTKQRHLRNGRQNSVKLHVSQVAAILTFSGASPLGTLIGWAVTNQSDSTSFLFAEATLQGLACGTFCYVVFCELLTNEIRDGSGDKPGKFLFLIIGWALVALVIVLSPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A029</accession>
    <name>A0A075A029_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163610.1">
        <property type="nucleotide sequence ID" value="XM_009165346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A029"/>
    <dbReference type="GeneID" id="20315528"/>
    <dbReference type="KEGG" id="ovi:T265_01340"/>
    <dbReference type="CTD" id="20315528"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15249" checksum="D4FDE0F8F8ACF973" modified="2014-10-01" version="1">MDQNPDSEQANHDITEQQPQSSAEETVAERSLVYLYPMDTEVVDSGGVERCRKEDPRSTGYVVSTSMLLNSGMNPTDFVTEDDLLEHLAERFLCKYSIHFEFNRDSQGCAALDCKLGITSRGDTVGVLNFEEKMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F8</accession>
    <name>A0A075A1F8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164232.1">
        <property type="nucleotide sequence ID" value="XM_009165968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F8"/>
    <dbReference type="STRING" id="6198.A0A075A1F8"/>
    <dbReference type="GeneID" id="20316046"/>
    <dbReference type="KEGG" id="ovi:T265_01858"/>
    <dbReference type="CTD" id="20316046"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25186" checksum="66302FFF80EB318B" modified="2014-10-01" version="1">MARSCATHAETASTETSVVRHPLVAHPACVDWEHLSSLTMATTDRNDANLLVSPFLNFDPSLLVSNSGEQFIFPEGEKHRGRFERSFSEIGAMVIGGEFLLPVPMALRPGATLGGIRGLYAGLSDAEIKKLPTVAIKRTQLLNHVTKSGGTLAQTAGSIGLIYALSDFLIHKLRGGADDEINTVTAATFTGCVYKSPGVFKPGGWQRCLRGGAVGLVVGSVAVAFTSWSHIKYMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M1</accession>
    <name>A0A075A1M1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596978">
        <property type="protein sequence ID" value="KER21289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174959.1">
        <property type="nucleotide sequence ID" value="XM_009176695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M1"/>
    <dbReference type="STRING" id="6198.A0A075A1M1"/>
    <dbReference type="GeneID" id="20324518"/>
    <dbReference type="KEGG" id="ovi:T265_10350"/>
    <dbReference type="CTD" id="20324518"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="38904" checksum="3FDD42B501E35EBE" modified="2014-10-01" version="1">MRSPVLFRGRPLLYHRSHYYPDEAVHVWELIHEALQNSERTHDTKTRILLVPNGSYRICGKMMAEAYSKLCPEVIRRIFIIGRTSHFLPYACALSQMDYLNSPLGKLPVDQETNDKLIKTGDFTYLDFPTDTKEQSIEMQLPFISKVMENQKGYFKVVPVYVGTLAHDQLTVVARRFRDYLQEPENAFIFSASLCHWGDIYGFNAQIPDAPTVLDSIKAFDERAIAAMKELRFRPFDEFLLDTKAKVLDNQIIALLLFMVRQLLNVNLHTLISMDEEKVVDQMRKLAKFKLMGQAWSYPDVTPADSCISYVSAVVELDEERYIPEEPPEPNPLNKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1V3</accession>
    <name>A0A075A1V3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163971.1">
        <property type="nucleotide sequence ID" value="XM_009165707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1V3"/>
    <dbReference type="GeneID" id="20315829"/>
    <dbReference type="KEGG" id="ovi:T265_01641"/>
    <dbReference type="CTD" id="20315829"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8554" checksum="10213C86A863B9D2" modified="2014-10-01" version="1">MLKANFAFCWYIKDDILLRTADFAQKKQLGVDNDCEDILSEMRREENPDLRRKNSVQTDLNSQSCQSAVALERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Z5</accession>
    <name>A0A075A1Z5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164021.1">
        <property type="nucleotide sequence ID" value="XM_009165757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Z5"/>
    <dbReference type="GeneID" id="20315879"/>
    <dbReference type="KEGG" id="ovi:T265_01691"/>
    <dbReference type="CTD" id="20315879"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9955" checksum="5A002AA60DDF19DF" modified="2014-10-01" version="1">MIRLPDGTNLDGTAATWVPELRGGERLLHPHWIYASLEELSEGLKYKVLDTVTLYTTQKRPNMDGIGLTGTGYQSYRRKSPYGTLRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A286</accession>
    <name>A0A075A286_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162294.1">
        <property type="nucleotide sequence ID" value="XM_009164030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A286"/>
    <dbReference type="GeneID" id="20314473"/>
    <dbReference type="KEGG" id="ovi:T265_00285"/>
    <dbReference type="CTD" id="20314473"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="255" mass="27115" checksum="0B29D4076A77F26B" modified="2014-10-01" version="1">MFMACRTAASAAETNGYLGFKYAARLKEPAVGNEMNIVPFVGLQDIPSFLVCALKSHGKRSSKVVKDSLALLSKELFGHSQPRLSISSIVNSSCTPEVMDSLAMGFRGPVADQTLPGKSKALTKFNSSPNSISSGSVPGKRSSKVVKDSLALLSKELFGHSQPRLSISSIVNSSCTPEVMDSLAMGFRGPVADQTLPVYKEIESGKKGNMGKRESSSALSPTTLTGDLAVKNADFRVPTAPTCGRRTYEGFSVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2F4</accession>
    <name>A0A075A2F4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163797.1">
        <property type="nucleotide sequence ID" value="XM_009165533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2F4"/>
    <dbReference type="GeneID" id="20315680"/>
    <dbReference type="KEGG" id="ovi:T265_01492"/>
    <dbReference type="CTD" id="20315680"/>
    <dbReference type="OrthoDB" id="6236174at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="644" mass="69715" checksum="4BCB88A1D93DB25A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A306</accession>
    <name>A0A075A306_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163581.1">
        <property type="nucleotide sequence ID" value="XM_009165317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A306"/>
    <dbReference type="GeneID" id="20315499"/>
    <dbReference type="KEGG" id="ovi:T265_01311"/>
    <dbReference type="CTD" id="20315499"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8021" checksum="06245F0B27C2C69E" modified="2014-10-01" version="1">MGPKKGGNGRGLSESFQQPCEWVLSLVTPFRCVAAMPPKVSTRAEVLPGCPYLYRESREATTDLLKKLLNSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A314</accession>
    <name>A0A075A314_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162459.1">
        <property type="nucleotide sequence ID" value="XM_009164195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A314"/>
    <dbReference type="STRING" id="6198.A0A075A314"/>
    <dbReference type="GeneID" id="20314610"/>
    <dbReference type="KEGG" id="ovi:T265_00422"/>
    <dbReference type="CTD" id="20314610"/>
    <dbReference type="OrthoDB" id="6221274at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="47936" checksum="0CD438BD101E3476" modified="2014-10-01" version="1">MPAPTTNSVPSEELTNGEDVETLKKVLAHVDMETGLKHRTLKRDPITGLGTVTNGAEDKVARARTQSLGRRIYNRKLISWDADEEPNKVSTSNSRPNRAMRNPIALTGELGAEVDSLRTTSRPRLGTPREPQRDPIAGLGNFGEKEWDPIWKYNGRMRRSKSSNGIRTNPITGQNMKSFEVMVEEKSPASRCRDRPSDIKRNIFTGENCSTYSVSPDMKSPSKKGTITSPRNAITGENCTSYDINSEVHTTKVRQSPKASNPLSGENVNVYTVSQEERQRPLKPYVYKNTVTGENLKSYQIIPIERNITPKPLKERQNPLSGENVKTYKYRFGESELAVKRRDLSSPLTGEGSRGRTYVVSVEEKSNIPLANGTDECRTHARARSSGPSRNILTGENCETFMVCREMRSERLKTPLTSGNSAPYNILTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3C3</accession>
    <name>A0A075A3C3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161944.1">
        <property type="nucleotide sequence ID" value="XM_009163680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3C3"/>
    <dbReference type="STRING" id="6198.A0A075A3C3"/>
    <dbReference type="GeneID" id="20314211"/>
    <dbReference type="KEGG" id="ovi:T265_00023"/>
    <dbReference type="CTD" id="20314211"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="341" mass="37941" checksum="E8B927CB0F649886" modified="2014-10-01" version="1">MSLLHNIMRQKLQTKPDGSGPDTFVEYNSHAKQLSMPPDAVDAASEAVATFLPLGLDTTTTKVPRWQEDLHRDVDYYGTVFGLGKPLWFSRADLTSNSPNIVTTNDLTTFSNSVGLAWWCRTLRRQCLRIVLSKLNLGYRTPLAEGSHGQANRGASLQTPTTAKINLSIRTSDKQSTVGLTESANEPEIKISLRSVSVYLITPHQKIQVNPLLHLSGGKGTSDFIDVSILISPLGRRELIERPNDKAEFAANGEEAHVYTYARERFEMGVDLASNPTNPAPQVSNRLRGRYGNELVHKITLMCHLSSGATFHKMQKKHTLSRQLIIQPIRIIWCFIASQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3K3</accession>
    <name>A0A075A3K3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_01136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABI family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163361.1">
        <property type="nucleotide sequence ID" value="XM_009165097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3K3"/>
    <dbReference type="STRING" id="6198.A0A075A3K3"/>
    <dbReference type="GeneID" id="20315324"/>
    <dbReference type="KEGG" id="ovi:T265_01136"/>
    <dbReference type="CTD" id="20315324"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11826">
        <property type="entry name" value="SH3_Abi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028455">
        <property type="entry name" value="ABI3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="539"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="597" mass="64273" checksum="E52DC0699947EFFF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4E4</accession>
    <name>A0A075A4E4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173976.1">
        <property type="nucleotide sequence ID" value="XM_009175712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4E4"/>
    <dbReference type="GeneID" id="20323765"/>
    <dbReference type="KEGG" id="ovi:T265_09597"/>
    <dbReference type="CTD" id="20323765"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="32219" checksum="CD541EF52B57FDB1" modified="2014-10-01" version="1">MGYRILIEDGNWSRINHVPPGGQETVFKGLMPCRYYCVSAYAWTALTRIQLIGKDCEQTKIKYLNAIRDFQAISLASGTEQAVQWKRPAGLSNCGLLHYSLIYRDRNSTMERRWFTSEGPHLISGLQPDTEYYYSVRAYVGELHSSESGWQYSKTNKELGPPKPYKAQAVPTVGGFRLTWNLPTAESGQHVKKYLVSFRNEAFLFINKGELEYAFTGLPFCQTLNLSLQSISYSNKASSKIYECVTTLGTVGIRPALDKVKLSRMTRKRTLTWDAACTTRTGCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4L5</accession>
    <name>A0A075A4L5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165665.1">
        <property type="nucleotide sequence ID" value="XM_009167401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4L5"/>
    <dbReference type="STRING" id="6198.A0A075A4L5"/>
    <dbReference type="GeneID" id="20317199"/>
    <dbReference type="KEGG" id="ovi:T265_03011"/>
    <dbReference type="CTD" id="20317199"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="10">
        <location>
            <begin position="63"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER30525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="367" mass="41089" checksum="5E563DD807917B09" modified="2014-10-01" version="1">MPCLNKAWQTVFLPLTQQTHGGDRGNDSHLPRRTKRPGDLEPKRRSCVLIREPMPSDDNSRVILVTGGSGLVGNGIKIALGNDRYNLSRSDEKWVFASSKDVDLTDAVATQKYFESLNPSFVIHLAAKVGGLFANMSNNLEFFRQNMQINDNVLASSLAVGVRKVVSCLSTCIFPDKTTYPIDETMIHNGPPHDSNYGYSYAKRMLDVLNRGYTQHYGVVYTSVVPTNVFGPFDNFNLENSHVLPGLIHKAYLAKEQNTPLVVSGTGTPLRQFIYSVDLGRLIVYVLREYNDPSPIILSVPEEDEISIRHAAETVARAMGMITPKLMVSFEKRRTLRNYVRCYRTSNSHLSKKLSKKLVDGSEKIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7E9</accession>
    <name>A0A075A7E9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162067.1">
        <property type="nucleotide sequence ID" value="XM_009163803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7E9"/>
    <dbReference type="STRING" id="6198.A0A075A7E9"/>
    <dbReference type="GeneID" id="20314334"/>
    <dbReference type="KEGG" id="ovi:T265_00146"/>
    <dbReference type="CTD" id="20314334"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="615" mass="66737" checksum="165E81F02B7D9680" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7K9</accession>
    <name>A0A075A7K9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172808.1">
        <property type="nucleotide sequence ID" value="XM_009174544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7K9"/>
    <dbReference type="STRING" id="6198.A0A075A7K9"/>
    <dbReference type="GeneID" id="20322852"/>
    <dbReference type="KEGG" id="ovi:T265_08673"/>
    <dbReference type="CTD" id="20322852"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="480" mass="53342" checksum="308DC0509EE8E59E" modified="2014-10-01" version="1">MIIMHLRISDARDGTNSGLWLALLVPIGLLRTGHQALAADILVTMTVLFSLCVKTGSALVFTCGVGVSFLTFSFNSTVPFRQIFVLGFVICCTRNLLRLFPKSFTIGEAILLTHLLIVFLHSYPLFLIVFICSFLVEYYSIPCTPLYGIGLLCFVAVLSFTVTWLILPGFPFFYVFRVKQLWCFFTPPHVALLSSWAFLLVLSVAITLFYHRCGRLGVPLDPSEHCTSPSASLCPTEINPSSFFFSTKQSNCINSKPTPDHCTYLRMKNRSSHTPTTPFWLRKVFHFNAGLVFALGLQFAPRLLSSCAACLLIAFGLFEWIRRRGPAPVAICFSNLVDPFRDERDSGALVFTPIALLLGLAIPVWWPDPVQPQLTVNIGRLCPNLKVSPSMWAGVLSISVGDSMAALVGRPWGRTRWPYSHRTFFGSFASLCICWLIVAHLHSWPVKSGFVPIVLGVLVEAYTEQIDNLVVPLVVMSAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9A3</accession>
    <name>A0A075A9A3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596823">
        <property type="protein sequence ID" value="KER24094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172172.1">
        <property type="nucleotide sequence ID" value="XM_009173908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9A3"/>
    <dbReference type="GeneID" id="20322362"/>
    <dbReference type="KEGG" id="ovi:T265_08183"/>
    <dbReference type="CTD" id="20322362"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="233" mass="26170" checksum="FD822E049CD73D74" modified="2014-10-01" version="1">MAWKRTAGLVIETLAHQAGHYRLPGWGSRDRRNQYSEIFRRPSGTLTGAHAPRLLPSMHSSPDLFNEKSTGTSVCKHQLCRLPPAMCRYLPHLPKSLVNETGSCSDYGTYAVFTVDVGETVSNHAQKEDQADPYRKRSPTGPFGCLRRVDKQCYDPPLIDGGMVYLDSGLVRWLATRRQAISAVPEIGTSKERSAISTFLEWTHSIVHPSRIRPEMTNNWASEALSLPDWVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAH5</accession>
    <name>A0A075AAH5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163504.1">
        <property type="nucleotide sequence ID" value="XM_009165240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAH5"/>
    <dbReference type="STRING" id="6198.A0A075AAH5"/>
    <dbReference type="GeneID" id="20315443"/>
    <dbReference type="KEGG" id="ovi:T265_01255"/>
    <dbReference type="CTD" id="20315443"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12160" checksum="C4337D1CCBACA44C" modified="2014-10-01" version="1">MDTRTHPSPTRQSAPRDSSWHNQVHKKSTELLIRKLPFERLVKGLAQDFKADLRLQSLGVSSLQEASKAYLVGLFENTNLYAIHAEQVTTMPKDIQFARRIRSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAM3</accession>
    <name>A0A075AAM3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163355.1">
        <property type="nucleotide sequence ID" value="XM_009165091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAM3"/>
    <dbReference type="GeneID" id="20315318"/>
    <dbReference type="KEGG" id="ovi:T265_01130"/>
    <dbReference type="CTD" id="20315318"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9140" checksum="52ACFF20883AC5DC" modified="2014-10-01" version="1">MRILVDDQNKYIHLDGWVRTSSGSCPETYISCFDGDSINAKEIYRAQNDQTMSCRSTGSALTLYAVRGSSCTFLYKFSYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC18</accession>
    <name>A0A075AC18_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171008.1">
        <property type="nucleotide sequence ID" value="XM_009172744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC18"/>
    <dbReference type="GeneID" id="20321445"/>
    <dbReference type="KEGG" id="ovi:T265_07266"/>
    <dbReference type="CTD" id="20321445"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14368" checksum="4E7FFB6E5D2C8F6A" modified="2014-10-01" version="1">MPPKGSTRARIVPGCPSLDRGSRETEVGFDGPTIRSVNPRSNNLIHLAHPPSGAPCIRQLVSLSSPYHEIYPYLPNFAHISVRLAVMPPEGRTRAGILPGCPNLARSSREAEVGFESRTFRLALLPLSYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADL4</accession>
    <name>A0A075ADL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162065.1">
        <property type="nucleotide sequence ID" value="XM_009163801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADL4"/>
    <dbReference type="STRING" id="6198.A0A075ADL4"/>
    <dbReference type="GeneID" id="20314332"/>
    <dbReference type="KEGG" id="ovi:T265_00144"/>
    <dbReference type="CTD" id="20314332"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="34680" checksum="0D0FCB3D8B4E477D" modified="2014-10-01" version="1">MNESLRMGLRVRRFECLREYLSITKLAALVGGNDQAVTNFRELSRYFRDIFCVFRTQQPNFTTFVLCHDSLAEFPLFYIWIWNGQVGWLEQGKPGSLCHVRLLRIMRNESLVNSISLKFSEAVNRAISKVRGSNPTSTTRLPLSRLGQPGSIPALVLPSGGMAARHRKSATAERFFMECRRYVLTSKHNMRRSRKITLMTKRAVTNFRELSRYFRDIFCVFRTQQPNFTTFVLCHDSLAEFPLFYIWIWNGQVGWLEQGKPGSLCQTEALRIMRNESLVNSISLKFSEAVNRAISKKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEW5</accession>
    <name>A0A075AEW5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169123.1">
        <property type="nucleotide sequence ID" value="XM_009170859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEW5"/>
    <dbReference type="STRING" id="6198.A0A075AEW5"/>
    <dbReference type="GeneID" id="20328013"/>
    <dbReference type="KEGG" id="ovi:T265_13846"/>
    <dbReference type="CTD" id="20328013"/>
    <dbReference type="OrthoDB" id="6268132at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19642" checksum="94722637A1949DBA" modified="2014-10-01" version="1">MVSISDEFTHLFSTQILEVHIRWAIIIEKNDATADLRKAVSFSFDRQFLSQSRANRLCPTGYRREWLQLWTPKETRQLFISGILVAYRVRYVLVEPLDIINNESPSLSNGQPYLRMTEKNVTRLHFQTTAGEHLFGVKYEFRVAAVSSTGIGPEVSDRIAVPEADYFWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF83</accession>
    <name>A0A075AF83_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168782.1">
        <property type="nucleotide sequence ID" value="XM_009170518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF83"/>
    <dbReference type="STRING" id="6198.A0A075AF83"/>
    <dbReference type="GeneID" id="20319678"/>
    <dbReference type="KEGG" id="ovi:T265_05496"/>
    <dbReference type="CTD" id="20319678"/>
    <dbReference type="OrthoDB" id="10062665at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="238"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="329"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="420"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="712"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="814" mass="91510" checksum="BABAE85BBAA0EA23" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFS8</accession>
    <name>A0A075AFS8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168215.1">
        <property type="nucleotide sequence ID" value="XM_009169951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFS8"/>
    <dbReference type="GeneID" id="20327837"/>
    <dbReference type="KEGG" id="ovi:T265_13670"/>
    <dbReference type="CTD" id="20327837"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10068" checksum="45FD4F0F90701384" modified="2014-10-01" version="1" fragment="single">MRLRPRPFSPKEREHKSPHVDPWPVQARGISCSEIKIKIKDKAFSCSTLPVPSCHATLREHEGWDTARLPKPRQGKSSGGGRIRTTDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHU9</accession>
    <name>A0A075AHU9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_03122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165791.1">
        <property type="nucleotide sequence ID" value="XM_009167527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHU9"/>
    <dbReference type="STRING" id="6198.A0A075AHU9"/>
    <dbReference type="GeneID" id="20317309"/>
    <dbReference type="KEGG" id="ovi:T265_03122"/>
    <dbReference type="CTD" id="20317309"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000132">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000211">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000262">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="746" mass="83174" checksum="053A570E1EE3C2FF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI60</accession>
    <name>A0A075AI60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165194.1">
        <property type="nucleotide sequence ID" value="XM_009166930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI60"/>
    <dbReference type="GeneID" id="20316820"/>
    <dbReference type="KEGG" id="ovi:T265_02632"/>
    <dbReference type="CTD" id="20316820"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11761" checksum="938CB510D761D435" modified="2014-10-01" version="1">MINLGYCWVRGCRPKLARAMRSYLPPPPNHRRTKLRKLQPLYDEYAVLTADNDDDDEYGGRTEDSGMHASKVEDLCRVTHLFCKSDAEVNLNYRDEKHDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIK9</accession>
    <name>A0A075AIK9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_12913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164485.1">
        <property type="nucleotide sequence ID" value="XM_009166221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIK9"/>
    <dbReference type="STRING" id="6198.A0A075AIK9"/>
    <dbReference type="GeneID" id="20327081"/>
    <dbReference type="KEGG" id="ovi:T265_12913"/>
    <dbReference type="CTD" id="20327081"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="254"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="623" mass="70980" checksum="E5B7FCE33C45BE8E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJJ5</accession>
    <name>A0A075AJJ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162701.1">
        <property type="nucleotide sequence ID" value="XM_009164437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJJ5"/>
    <dbReference type="GeneID" id="20314797"/>
    <dbReference type="KEGG" id="ovi:T265_00609"/>
    <dbReference type="CTD" id="20314797"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="18700" checksum="81A8411A88390859" modified="2014-10-01" version="1">MKSLRKDRERWWTMKASAAEKSRALYQLDRSTSPRKAMASETMSEIDTGECNVNLNRPSAEEREYQITLLKRDKISKSGGLYPALSIEGGKSMTTLMWQWFSGALDLFYGTRYYVQPFRRENSDASPIQMHPKCAGEIVVTRSPRMSGVRSSKHGHWICTAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJN8</accession>
    <name>A0A075AJN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162435.1">
        <property type="nucleotide sequence ID" value="XM_009164171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJN8"/>
    <dbReference type="GeneID" id="20314586"/>
    <dbReference type="KEGG" id="ovi:T265_00398"/>
    <dbReference type="CTD" id="20314586"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="19283" checksum="99A26C95F3905001" modified="2014-10-01" version="1">MPDCPVEETGSILRLLLDSTGDVVSGGGFLRALPMLFEEVGAPRDAFKRLKSDNSLGEVIGAHQQCKASGMTEFESAHLNVLQLLHKSISESSSLNGETCLRLSDVISLPSARKGNPRKAIFFSLGPNFANGHVRLTPGPHGSRHLSSTETRAFLHLHATGRSTVVDKKLLVGWFLPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJS4</accession>
    <name>A0A075AJS4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRAPPC10/Trs130 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162341.1">
        <property type="nucleotide sequence ID" value="XM_009164077.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJS4"/>
    <dbReference type="GeneID" id="20314520"/>
    <dbReference type="KEGG" id="ovi:T265_00332"/>
    <dbReference type="CTD" id="20314520"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1442" mass="160805" checksum="BF61BA01FB4DD426" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AK02</accession>
    <name>A0A075AK02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162048.1">
        <property type="nucleotide sequence ID" value="XM_009163784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AK02"/>
    <dbReference type="GeneID" id="20314315"/>
    <dbReference type="KEGG" id="ovi:T265_00127"/>
    <dbReference type="CTD" id="20314315"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126383" checksum="ACC5B2B86220E9CC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AK07</accession>
    <name>A0A075AK07_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162069.1">
        <property type="nucleotide sequence ID" value="XM_009163805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AK07"/>
    <dbReference type="STRING" id="6198.A0A075AK07"/>
    <dbReference type="GeneID" id="20314336"/>
    <dbReference type="KEGG" id="ovi:T265_00148"/>
    <dbReference type="CTD" id="20314336"/>
    <dbReference type="OrthoDB" id="5597848at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ARMET N-terminal" evidence="9">
        <location>
            <begin position="57"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="8">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="219" mass="24873" checksum="374B9926D62D7534" modified="2014-10-01" version="1">MINEVSSLANWLDQSLIPKWLFFTTAVEMCRLRLMFALILLISAGIEKVAGEGEGNKCDVCVQVVKRLIEQLGNSRGDPKEVRTKFEALCRDLKKSSPEGVESRFCYLVGGHEESAAKTVMYLVDQVTTYKPAEKICMELDKKISGVCDFKYKDKIDWSKVDLNRANLKQLKKILASYDIYECPHCIEKSDYVELVKDEVRKRDPEAAKLLGISPKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUX2</accession>
    <name>A0A074YUX2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600548">
        <property type="protein sequence ID" value="KER18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177750.1">
        <property type="nucleotide sequence ID" value="XM_009179486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUX2"/>
    <dbReference type="STRING" id="6198.A0A074YUX2"/>
    <dbReference type="GeneID" id="20326419"/>
    <dbReference type="KEGG" id="ovi:T265_12251"/>
    <dbReference type="CTD" id="20326419"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21143" checksum="04122E1D03F49CA2" modified="2014-10-01" version="1">MNFPSFISTLRVSNSAQVVSKAFGSVQSLFENRPSVECLSVDLAARLLTALYTYRPGDPAIFEVSTAATDAKTGFTGVEVLVSWIRAVRAGCSYLCDLTSRVFDDTSDAVNRIGVQRLALEHLDRLIKGLLDLLMTTPLPKLRKTVSDILDSIFIHEFVSIPLVFKKLCDRLSGIISVSASILCNISVDPSCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWD4</accession>
    <name>A0A074YWD4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SET domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597344">
        <property type="protein sequence ID" value="KER19081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177173.1">
        <property type="nucleotide sequence ID" value="XM_009178909.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YWD4"/>
    <dbReference type="GeneID" id="20326189"/>
    <dbReference type="KEGG" id="ovi:T265_12021"/>
    <dbReference type="CTD" id="20326189"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="889"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="1298"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER19081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1431" mass="159343" checksum="784D2121655201CA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWQ5</accession>
    <name>A0A074YWQ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_15623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597291">
        <property type="protein sequence ID" value="KER19201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177048.1">
        <property type="nucleotide sequence ID" value="XM_009178784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWQ5"/>
    <dbReference type="STRING" id="6198.A0A074YWQ5"/>
    <dbReference type="GeneID" id="20329788"/>
    <dbReference type="KEGG" id="ovi:T265_15623"/>
    <dbReference type="CTD" id="20329788"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="9">
        <location>
            <begin position="111"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER19201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="725" mass="80814" checksum="C4358646A91FC512" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX36</accession>
    <name>A0A074YX36_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_11949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="KL597293">
        <property type="protein sequence ID" value="KER19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177057.1">
        <property type="nucleotide sequence ID" value="XM_009178793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX36"/>
    <dbReference type="STRING" id="6198.A0A074YX36"/>
    <dbReference type="GeneID" id="20326117"/>
    <dbReference type="KEGG" id="ovi:T265_11949"/>
    <dbReference type="CTD" id="20326117"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000039">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="413" mass="46043" checksum="538138560541A748" modified="2014-10-01" version="1">MPGVNAVLNHMKDFCGRVISGSWKGYTGKAITDIVNIGIGGSDLGPVMATECLKPYANHLRVHFVSNIDGTHMAETLKKLNPETTLFIIASKEVHVAKHFVALSTNSDEVKKFGIAEENMFEFWDWVGGRYSLWSAIGLSIALYVGMDNFIQLLEGAHAMDKHFKEAPLHKNLPVILAVLGVLYINVYGAETHAILPYDQYMSRFAAYFQQGDMESNGKFVTRASKEVDYATGPIVWGEPGTNGQHAFYQLIHQGTRLIPADFLIPVHTQNPIQGGLHHEILISNFLAQTEALMTGKSRDEVHTELFNSGVTGEKLEALSLHKSFKGNRPTNSIVFSRLTPYMLGCLIAMYEHKIFVQGVIWDINSYDQWGVELGKVLAKKIQPELKTPDPITTHDSSTNGLINFIKEEMKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY57</accession>
    <name>A0A074YY57_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597152">
        <property type="protein sequence ID" value="KER19706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176553.1">
        <property type="nucleotide sequence ID" value="XM_009178289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY57"/>
    <dbReference type="GeneID" id="20325765"/>
    <dbReference type="KEGG" id="ovi:T265_11597"/>
    <dbReference type="CTD" id="20325765"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="24447" checksum="032EB21C5626F427" modified="2014-10-01" version="1">MLQPAKRYESVGQWIGNMACLLHAPISVWWNTVELIKWECSKSKLMHPYYQTINPAGPVTLYFGTSIAGSTKTSIPASPLPEENRMKTDLEPSQRDQTLTGCEDTCASVDHWMRSDPHSLLDTCGNNRKLMRCITSVGQWIGNMACLLHAPISVWWNTVELIKWECSKSKLMHPYYQTINPAGPVTLYFGTSIAGSTKTSIPASPLPEENRMKTDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYR8</accession>
    <name>A0A074YYR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597116">
        <property type="protein sequence ID" value="KER19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176318.1">
        <property type="nucleotide sequence ID" value="XM_009178054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYR8"/>
    <dbReference type="GeneID" id="20325577"/>
    <dbReference type="KEGG" id="ovi:T265_11409"/>
    <dbReference type="CTD" id="20325577"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="8774" checksum="231A19EF2810C8DC" modified="2014-10-01" version="1">MTFKVSAATPASYNVIDLHSWSRSSRESINHSSSVGPPVGSEYNATVHEDVMSFLDVTRFHMLAPENLQKMDFFPESPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYT9</accession>
    <name>A0A074YYT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597113">
        <property type="protein sequence ID" value="KER19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176290.1">
        <property type="nucleotide sequence ID" value="XM_009178026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYT9"/>
    <dbReference type="GeneID" id="20329584"/>
    <dbReference type="KEGG" id="ovi:T265_15419"/>
    <dbReference type="CTD" id="20329584"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9696" checksum="388428B2EBE7B5E1" modified="2014-10-01" version="1" fragment="single">MNFSDVPGEIDKIMSVLACLLQGPLIAHASPQKSSTTEMLINHAHQNGSSSKKRTSILQMPRCVYMDEFSLRFIANDCLSAGRSVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ03</accession>
    <name>A0A074YZ03_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597120">
        <property type="protein sequence ID" value="KER19903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176346.1">
        <property type="nucleotide sequence ID" value="XM_009178082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ03"/>
    <dbReference type="GeneID" id="20325595"/>
    <dbReference type="KEGG" id="ovi:T265_11427"/>
    <dbReference type="CTD" id="20325595"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="18542" checksum="E90ED9E747205ABA" modified="2014-10-01" version="1">MHNHNPVALVGFCKEFYWDAQSSRLAEIPRATYRQRAMYFLRRTPLSRLQTVQFRMLSIAEDFRIRLCKQKLSPEIVAGDAFGTSASQKKTKRKRRTLVVENMALYTLTDQERTSLHFSQARVLRTLNVTSQLLLQETTYVHSFKDGKLSQFEDVHEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZT4</accession>
    <name>A0A074YZT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597069">
        <property type="protein sequence ID" value="KER20301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175940.1">
        <property type="nucleotide sequence ID" value="XM_009177676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZT4"/>
    <dbReference type="STRING" id="6198.A0A074YZT4"/>
    <dbReference type="GeneID" id="20325278"/>
    <dbReference type="KEGG" id="ovi:T265_11110"/>
    <dbReference type="CTD" id="20325278"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="180" mass="19967" checksum="0A88342A07868065" modified="2014-10-01" version="1">MLHFYISEHYSMSGKVDDLYLPNAVILRIIRDSLPDRTVVSREARSAISKAASSFILYVTSLASTHCEAAKRKTLAVGDILAALKDMQFEHYIVELQTFLEQYRARASQKKAAKRPPASSDEPALVSETASVEQTELLEEDGQDTGTIDIVDDTEDLEPVQPFATSQTPSTSHQTVETDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0S3</accession>
    <name>A0A074Z0S3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597036">
        <property type="protein sequence ID" value="KER20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175614.1">
        <property type="nucleotide sequence ID" value="XM_009177350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0S3"/>
    <dbReference type="GeneID" id="20325029"/>
    <dbReference type="KEGG" id="ovi:T265_10861"/>
    <dbReference type="CTD" id="20325029"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10262" checksum="F93D71581521CBE4" modified="2014-10-01" version="1">MTGEDFPCPQPTTLEPCISLLQMAPQQTSTSLSKSKAQLLSTAADKKPTEVRQKIVRDGSDPGFAMLLYDKLVHLKLAQVESSPIGDVCEDQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0X7</accession>
    <name>A0A074Z0X7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175627.1">
        <property type="nucleotide sequence ID" value="XM_009177363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0X7"/>
    <dbReference type="STRING" id="6198.A0A074Z0X7"/>
    <dbReference type="GeneID" id="20329438"/>
    <dbReference type="KEGG" id="ovi:T265_15273"/>
    <dbReference type="CTD" id="20329438"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8736" checksum="4ABF3281D8DBA870" modified="2014-10-01" version="1">MRFSSHERERLLRKFHAMDTDRNGALSSKEVRTCVENSGLPPAAVDEFMNLFDLDADGKVTLNEYITALGLNPLPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z286</accession>
    <name>A0A074Z286_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175122.1">
        <property type="nucleotide sequence ID" value="XM_009176858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z286"/>
    <dbReference type="STRING" id="6198.A0A074Z286"/>
    <dbReference type="GeneID" id="20329326"/>
    <dbReference type="KEGG" id="ovi:T265_15161"/>
    <dbReference type="CTD" id="20329326"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="1">
        <location>
            <begin position="189"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="276" mass="31506" checksum="E3F7EDD085C69BB9" modified="2014-10-01" version="1" fragment="single">MASELELDDKRIEFLADYVLNSNKLKPDKWMKLWNVEEMRKTIINFFENADQMHLFILLTPAGALQAQTQFPSSSKAKSCYFMKKEKCSIKKDSPVNKLLNYGDLSSNPLENFSAFVDEVLLPLVSNKENYMSWPDIIYDDIVKHARGLKRQTDIIVGQAKGKTFLPLLTDSGDVSSGKKERKISRSLVYSIESLVIAWSHQIHKALLKDSAKPLLDNLHPNPLVEIDFWKAKAADLLNIFEQLNASKVRQMAKILEQANSSYFLPFKDMFKSVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2G9</accession>
    <name>A0A074Z2G9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597155">
        <property type="protein sequence ID" value="KER19687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176567.1">
        <property type="nucleotide sequence ID" value="XM_009178303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2G9"/>
    <dbReference type="GeneID" id="20329640"/>
    <dbReference type="KEGG" id="ovi:T265_15475"/>
    <dbReference type="CTD" id="20329640"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12498" checksum="600FCAD50CA46CD6" modified="2014-10-01" version="1" fragment="single">MYWGLKRRKKQEIFPPFPNGDRVTQESTTRRGSDTAVCCVGHLQVSVETLSQQRMCYYSPRWPKQPAFYETKVAPESQTTSELTLAPSWPCPPSACAVKQTVMTLVSIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z396</accession>
    <name>A0A074Z396_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174762.1">
        <property type="nucleotide sequence ID" value="XM_009176498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z396"/>
    <dbReference type="GeneID" id="20324366"/>
    <dbReference type="KEGG" id="ovi:T265_10198"/>
    <dbReference type="CTD" id="20324366"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6691" checksum="820556A1BE507C82" modified="2014-10-01" version="1">MEPDGPKLVLRRKSSAGTRKTFVRLIGDEAASLHQLCSEAFTKLPNPQSLPYSNASNAVHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z399</accession>
    <name>A0A074Z399_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597108">
        <property type="protein sequence ID" value="KER19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176261.1">
        <property type="nucleotide sequence ID" value="XM_009177997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z399"/>
    <dbReference type="GeneID" id="20329578"/>
    <dbReference type="KEGG" id="ovi:T265_15413"/>
    <dbReference type="CTD" id="20329578"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11007" checksum="29869BD6183BA43E" modified="2014-10-01" version="1" fragment="single">MVAGLKSVDYETRLGMLDLFPPAGSKGCLISFPLLCGSKHGIHLASSILQLLSSFCGFGRRQSINLLFRQSEVSAADPLQCLVSERKDSQKGTQQLYSEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z478</accession>
    <name>A0A074Z478_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596936">
        <property type="protein sequence ID" value="KER21858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174404.1">
        <property type="nucleotide sequence ID" value="XM_009176140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z478"/>
    <dbReference type="STRING" id="6198.A0A074Z478"/>
    <dbReference type="GeneID" id="20324092"/>
    <dbReference type="KEGG" id="ovi:T265_09924"/>
    <dbReference type="CTD" id="20324092"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8829" checksum="AB2374C3EBACE9DD" modified="2014-10-01" version="1">MKEITKRLGAVGTARLPGWGPRDPRCAWLETLQDMAANRCQWCSCRQFLSRSSEEPSNLMLFTTIGYHPLREIMAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z517</accession>
    <name>A0A074Z517_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_09672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596915">
        <property type="protein sequence ID" value="KER22166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174087.1">
        <property type="nucleotide sequence ID" value="XM_009175823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z517"/>
    <dbReference type="STRING" id="6198.A0A074Z517"/>
    <dbReference type="MEROPS" id="M01.010"/>
    <dbReference type="GeneID" id="20323840"/>
    <dbReference type="KEGG" id="ovi:T265_09672"/>
    <dbReference type="CTD" id="20323840"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="93"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="544"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER22166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="910" mass="101564" checksum="CD233B1DC2BABDA8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5B9</accession>
    <name>A0A074Z5B9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600491">
        <property type="protein sequence ID" value="KER18510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177743.1">
        <property type="nucleotide sequence ID" value="XM_009179479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5B9"/>
    <dbReference type="STRING" id="6198.A0A074Z5B9"/>
    <dbReference type="GeneID" id="20330174"/>
    <dbReference type="KEGG" id="ovi:T265_16009"/>
    <dbReference type="CTD" id="20330174"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="17537" checksum="FBB1AC47B1B3E354" modified="2014-10-01" version="1" fragment="single">CTNEISNLLFLDSSSNTAAAQAFAVATAGSACPLAAAGIMGLGPNLNRAALRFSAGTASAAAANIGYKTVACTLPSTSAVTSTLGGSTTVTTLSSLSNISPGSFQFNGRASAAGQNNAASINGTSNNLTQAPQNNIDQQTRRSMMMATASCLRVLNVVRHWITKFPDVRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6C6</accession>
    <name>A0A074Z6C6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596885">
        <property type="protein sequence ID" value="KER22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173567.1">
        <property type="nucleotide sequence ID" value="XM_009175303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6C6"/>
    <dbReference type="GeneID" id="20323448"/>
    <dbReference type="KEGG" id="ovi:T265_09275"/>
    <dbReference type="CTD" id="20323448"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9405" checksum="BE30BF2CCBB25D70" modified="2014-10-01" version="1">MRVGVTTVIPWACIRASTKPLTERDAVQLDLIFICATKQRSERHDNVIMKLVTAPLNPQTNTDSNFDCPSTRRGIAFLGRYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Z3</accession>
    <name>A0A074Z6Z3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173397.1">
        <property type="nucleotide sequence ID" value="XM_009175133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Z3"/>
    <dbReference type="SMR" id="A0A074Z6Z3"/>
    <dbReference type="STRING" id="6198.A0A074Z6Z3"/>
    <dbReference type="GeneID" id="20323315"/>
    <dbReference type="KEGG" id="ovi:T265_09136"/>
    <dbReference type="CTD" id="20323315"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="248" mass="27963" checksum="F02E0429CEC54CFD" modified="2014-10-01" version="1">MSADQSFPSHSKKFDPREDAACLYRACEGHGRESREAEVGFNDGRDVGPPLFGKKQYTQASKNSKKSEGETEFHTDSALLLTVIRCYIQEAYPVQEWSGVQAARRSGIKASSDWSKVDPVANHDPVVAECRLPKRIRKASESVCEGEMIIIEIAGNRSMAQRLEIRKVFERIYEMDLTKAIASKMKGNARFLAVNLFRTPMELLAHQLYRSLNERHSVNTSVLTNILCCCNHIEIHLLGKAYNTCKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z785</accession>
    <name>A0A074Z785_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="2 5">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="2 5"/>
    <dbReference type="EMBL" id="KL597348">
        <property type="protein sequence ID" value="KER19075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177179.1">
        <property type="nucleotide sequence ID" value="XM_009178915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z785"/>
    <dbReference type="STRING" id="6198.A0A074Z785"/>
    <dbReference type="GeneID" id="20326191"/>
    <dbReference type="KEGG" id="ovi:T265_12023"/>
    <dbReference type="CTD" id="20326191"/>
    <dbReference type="OrthoDB" id="545675at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="317" mass="36061" checksum="6EA1999556A7A454" modified="2014-10-01" version="1">MACASHRQHIRSWSRRRSHRTGHLQSKTYARTGAGAVTQYRTLKKFKKNCEDVAPFRCLAAMPSEGSTMTRIMSSCPSLDRDSRKAEVRSGTITVVIVITMKSTSVLNTDASLPYAYDLFESLIVRINVDNEGICAWLLQSFRDNLKIIQVCHRVGSERCIIVRYELLVLNPERELKVLTGKQIFSWSSRSTKVLHGFLRTWMIDNLKIIQACHRVGSERCIIVRYELLVLNPERELKVLTEFLHVPWDPVMLNHEKLIGNISQLNPVLFAQPREGWKRARGGQALTSQRSIEAITSKLSCAGHCRLPGWGPRDGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7M2</accession>
    <name>A0A074Z7M2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597291">
        <property type="protein sequence ID" value="KER19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177052.1">
        <property type="nucleotide sequence ID" value="XM_009178788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7M2"/>
    <dbReference type="GeneID" id="20326111"/>
    <dbReference type="KEGG" id="ovi:T265_11943"/>
    <dbReference type="CTD" id="20326111"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9947" checksum="5F47C128CAA52588" modified="2014-10-01" version="1">MDTRRPKEYPTSWSEDLASALYFSSNSRNSNDFNRLKTLSKNSEASFLVETTKYLERPATLVRLKETKILTTGVNVPPLIDFFVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z978</accession>
    <name>A0A074Z978_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176467.1">
        <property type="nucleotide sequence ID" value="XM_009178203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z978"/>
    <dbReference type="STRING" id="6198.A0A074Z978"/>
    <dbReference type="GeneID" id="20325692"/>
    <dbReference type="KEGG" id="ovi:T265_11524"/>
    <dbReference type="CTD" id="20325692"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="394"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="572" mass="61519" checksum="C47F0347A78B906B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9E5</accession>
    <name>A0A074Z9E5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172519.1">
        <property type="nucleotide sequence ID" value="XM_009174255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9E5"/>
    <dbReference type="GeneID" id="20322627"/>
    <dbReference type="KEGG" id="ovi:T265_08448"/>
    <dbReference type="CTD" id="20322627"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="29046" checksum="D06AFF02915B12EB" modified="2014-10-01" version="1">MTVFQNVSVYLYNERCSCPRCDINSWAAFSFKVLSMLSMSGSAFWIIFNGKWVAQILRYGWLGVGRVYTDQLSKVALQWPANIHPCPYYLTLSGQWSFRTKVEQDIAETQGTVWKLFTKSTQLIFGFKGQTNAVSLGAYQTTTPVCKKCRTFFLRYRIYGFVQVKVNAPRRWFIITYVLVRQLDCKVLGSAGPHQYHKEKELVLCRWRLLHALAPSHRIEFEILCPLPSPLEAFRYYRLHHRELNKPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAL4</accession>
    <name>A0A074ZAL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171912.1">
        <property type="nucleotide sequence ID" value="XM_009173648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAL4"/>
    <dbReference type="STRING" id="6198.A0A074ZAL4"/>
    <dbReference type="GeneID" id="20322150"/>
    <dbReference type="KEGG" id="ovi:T265_07971"/>
    <dbReference type="CTD" id="20322150"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="509" mass="55912" checksum="8C017F99E97D61EE" modified="2014-10-01" version="1">MGNVCVARAKNVSRGQQVLKRKHNTKSRTSGRFEYVPKHQLVASKTKYFDDIRDGKIDLSSNDLYSRVKTRRRATEPSTTATSSCDSITSTNNSGTEETGQTGAQPTLTLLPYTLKREPASPSSDCFNAGESLSGFQSTVDSTESERMKPNFSDPADDLPESVPDSMAQCYSVPEFESCPEDPAPQSKITRGVQCDEPSFPSGRPLVTLCTSCVQAQPNLCDMAVSPLFSARCSPVVLEPSDCFTTSSKGDEVNLPSETVDSVRVHVDNSSEEMIKDTGHPPETPEERGSGRTVSCLRDLVQAYFSLINHFQRPQLHLSPHQTHQRTPQSGRFSRFDVTSLEELPALQIYSPLARIRTQKDLLEALDNQRWGLIATLPTHMPEGDLQLQRFVVTLESILSPGTSTCAEGGSSDRPLVNQEVVVASIAKSTGRSLVLESLLSLGLDPDMLVTVDQSAPAWSLLTLAVRLRRIHVAPVPRTSMDCLPRILGCRLSRNLFRCSTYHVLIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAP3</accession>
    <name>A0A074ZAP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_09337</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="KL596888">
        <property type="protein sequence ID" value="KER22637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173634.1">
        <property type="nucleotide sequence ID" value="XM_009175370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAP3"/>
    <dbReference type="STRING" id="6198.A0A074ZAP3"/>
    <dbReference type="GeneID" id="20323510"/>
    <dbReference type="KEGG" id="ovi:T265_09337"/>
    <dbReference type="CTD" id="20323510"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER22637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="731" mass="82246" checksum="64F7A7130CB34BC1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBC4</accession>
    <name>A0A074ZBC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597048">
        <property type="protein sequence ID" value="KER20525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175738.1">
        <property type="nucleotide sequence ID" value="XM_009177474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBC4"/>
    <dbReference type="GeneID" id="20325120"/>
    <dbReference type="KEGG" id="ovi:T265_10952"/>
    <dbReference type="CTD" id="20325120"/>
    <dbReference type="OrthoDB" id="6247695at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="329" mass="35930" checksum="16FE6C74278E75A2" modified="2014-10-01" version="1">MVTKYAISSKACFVVTTELMDIQSTIPKADKSTQTGAETPRGRPIKTHRGLPGFNTILQCGTTKLGESMFTVPNAPSVVYNTPTYGRIDRMFGETVESPSRVQTLETIYDVTAKESATHVVLNKPEQPMDTPSNSTHPLLIAHDASGTDTVKNRNRSPLVDLSNDVFSSGFQETTEVKQRSGSRRMLFEIFHDSYLQPSATKPLCPTSKVSDTSAESTLTNPSSFHQSVPRATTVSSVEVSGIPLLKDQSTVKPTTVTSTTPVMFPNADSMDDTAVFELLDYHLAQAQRNSVTSIKSSARFPPAFSVDSPTRLFERLLGNPDPRTTPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBX3</accession>
    <name>A0A074ZBX3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171594.1">
        <property type="nucleotide sequence ID" value="XM_009173330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBX3"/>
    <dbReference type="GeneID" id="20321910"/>
    <dbReference type="KEGG" id="ovi:T265_07731"/>
    <dbReference type="CTD" id="20321910"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9156" checksum="CC39A5790B48B412" modified="2014-10-01" version="1">MDDMATNADNCSSKRCRIEIASSCTRFNSRWLSVVAFSEKKPYCEEKNKRGRVKDLVLAYHSESEMIKSPKIHSGNLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCA1</accession>
    <name>A0A074ZCA1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171505.1">
        <property type="nucleotide sequence ID" value="XM_009173241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCA1"/>
    <dbReference type="GeneID" id="20321847"/>
    <dbReference type="KEGG" id="ovi:T265_07668"/>
    <dbReference type="CTD" id="20321847"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11146" checksum="BC2A564E185245A8" modified="2014-10-01" version="1">MDLARSTLAEWILQDGLPDFAYSTHGRTADIRATSDKETAHLILTCSRAADLSTLEAKSYPDQQKHQIGVQLRVVVEFGFNQNMRLAETWVPRRRDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD08</accession>
    <name>A0A074ZD08_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0506 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171130.1">
        <property type="nucleotide sequence ID" value="XM_009172866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD08"/>
    <dbReference type="GeneID" id="20321546"/>
    <dbReference type="KEGG" id="ovi:T265_07367"/>
    <dbReference type="CTD" id="20321546"/>
    <dbReference type="OrthoDB" id="5021976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021712">
        <property type="entry name" value="UPF0506"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11703">
        <property type="entry name" value="UPF0506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0960">Knottin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705399" description="UPF0506 domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0506" evidence="7">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9615" checksum="643A27BC5F73BD6B" modified="2014-10-01" version="1">MSGYFILLSLFAIFVVRGSAFFECKGFGQWCDGTIFNRCCDNLNCQLDRFASGTCQLCIGSGYACGLSSQCCSNDCQWFRCRPMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD12</accession>
    <name>A0A074ZD12_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009176889.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_10501"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER21085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8260" checksum="F69BC0BFB409283C" modified="2014-10-01" version="1">MLLVVVNLLQTDLEYQAYLIGSQLTRVVTEDIPSMENPDLVVKQEKDIKQEGKRIVLGAWSEQKNLPDNYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009172759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD85"/>
    <dbReference type="GeneID" id="20321460"/>
    <dbReference type="KEGG" id="ovi:T265_07281"/>
    <dbReference type="CTD" id="20321460"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7550" checksum="4468197BC5C7A22C" modified="2014-10-01" version="1">MGPTMNSIQLVGTVPKMEVPPDGACGRHTVWRDHTFKVRMKHDWRSRGVGIAGIEENVTNSGKYQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDF1</accession>
    <name>A0A074ZDF1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger, C4 type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER25326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170922.1">
        <property type="nucleotide sequence ID" value="XM_009172658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDF1"/>
    <dbReference type="STRING" id="6198.A0A074ZDF1"/>
    <dbReference type="GeneID" id="20321381"/>
    <dbReference type="KEGG" id="ovi:T265_07202"/>
    <dbReference type="CTD" id="20321381"/>
    <dbReference type="OrthoDB" id="5984981at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07167">
        <property type="entry name" value="NR_DBD_Lrh-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="830"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="1098"/>
        </location>
    </feature>
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            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
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            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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        </location>
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        </location>
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            <end position="1087"/>
        </location>
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        <source>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="133475" checksum="C4C9C2977A18789A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE70</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596829">
        <property type="protein sequence ID" value="KER23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172329.1">
        <property type="nucleotide sequence ID" value="XM_009174065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE70"/>
    <dbReference type="GeneID" id="20322488"/>
    <dbReference type="KEGG" id="ovi:T265_08309"/>
    <dbReference type="CTD" id="20322488"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15577" checksum="914905F341EFB976" modified="2014-10-01" version="1">MGPDMISLDGQPIICVSNRMCCIRPPHVSFGMLFEISRYMYIRNTRVSRYLKYRTNSSMRRLGTANSVAWKPKLFAKHNANKFHQFYRNPSSWQGIQVDETKRPHSARNLMSDFGDAERSCFGTEGTYVQLGPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEL9</accession>
    <name>A0A074ZEL9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate-specific endoribonuclease</fullName>
            <ecNumber evidence="11">4.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA</text>
            <dbReference type="Rhea" id="RHEA:67792"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17354"/>
            <dbReference type="Rhea" id="RHEA-COMP:17356"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173117"/>
            <dbReference type="ChEBI" id="CHEBI:173224"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170638.1">
        <property type="nucleotide sequence ID" value="XM_009172374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEL9"/>
    <dbReference type="STRING" id="6198.A0A074ZEL9"/>
    <dbReference type="GeneID" id="20321147"/>
    <dbReference type="KEGG" id="ovi:T265_06968"/>
    <dbReference type="CTD" id="20321147"/>
    <dbReference type="OrthoDB" id="430326at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF11">
        <property type="entry name" value="URIDYLATE-SPECIFIC ENDORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="12">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="232" mass="26498" checksum="9477786B846AE563" modified="2014-10-01" version="1">MKNSNPQADEAPHPLFAEVNLPALISRIRTIPAFTKLLDNYVASVGVPETRTSEHEEEIRSFLTEIMKTDILKETRKFLKQEGMRFISEADFFHFLEQLWFAPYKRKRHNDSSAFEHVFVGEKKGSEVSGFHNWIQFLRLESSGVLDYQGYFAKQCGDPPRIVTLAFRMKDGSTKPRGSMFLGTSPEFEMALYTVIFLSGHNHVNVRLDSCKAVVTCHPIHGGSYIGTCYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEX7</accession>
    <name>A0A074ZEX7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596764">
        <property type="protein sequence ID" value="KER25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170407.1">
        <property type="nucleotide sequence ID" value="XM_009172143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEX7"/>
    <dbReference type="STRING" id="6198.A0A074ZEX7"/>
    <dbReference type="GeneID" id="20328291"/>
    <dbReference type="KEGG" id="ovi:T265_14125"/>
    <dbReference type="CTD" id="20328291"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="18090" checksum="091D105DA8A70E07" modified="2014-10-01" version="1" fragment="single">GLDAAGKTTILYKLKLGEVVTTIPTIGFNVEMVEYKNISFTVWDVGGQDRIRRLWRHYFQNTQGLIFVVDSNDRERVNEAADELKRMLSEDELRDVVILVFANKQDLPNAMSSAELTDKLGLREIRNRPWFIQQACATQGQGLFEGLDWLSNEVSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFJ1</accession>
    <name>A0A074ZFJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171844.1">
        <property type="nucleotide sequence ID" value="XM_009173580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFJ1"/>
    <dbReference type="GeneID" id="20322099"/>
    <dbReference type="KEGG" id="ovi:T265_07920"/>
    <dbReference type="CTD" id="20322099"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="16483" checksum="3EE7D1B5D149EA55" modified="2014-10-01" version="1">MGYEYAARQSRRVDVLKCEAVLGFTLPRRQWVKWNEWNKQDVNLGHPEEEFDPTLLAELFDGTRLATAELYFNPTRCWLARDRSVEEAARAISSGQVAHLWTKNNGCDRSLYELSMDIVNMCRAYQRRAVTMKCIPHILLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFR1</accession>
    <name>A0A074ZFR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170246.1">
        <property type="nucleotide sequence ID" value="XM_009171982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFR1"/>
    <dbReference type="STRING" id="6198.A0A074ZFR1"/>
    <dbReference type="GeneID" id="20320841"/>
    <dbReference type="KEGG" id="ovi:T265_06662"/>
    <dbReference type="CTD" id="20320841"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="350" mass="40500" checksum="DED843625393C710" modified="2014-10-01" version="1">MGNAQTAKKGDPADVKAFLEEAKKEFLERWEKPTQNTSTLDAFDRIKTLGTGSFGRVMLVQHKASKNYYAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVRLDYHFKDNSNLYMVLEFVNGGEMFSYLRRVGRFNECHARFYAGQVVLAFEYLHYLELVYRDLKPENILIDQFGYLKITDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKTHKWFATTDWIATYKRELDAPFTPKCSGAGDASNFDDYEEEPLRIATTEKCAKEFNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFS0</accession>
    <name>A0A074ZFS0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170194.1">
        <property type="nucleotide sequence ID" value="XM_009171930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFS0"/>
    <dbReference type="GeneID" id="20320796"/>
    <dbReference type="KEGG" id="ovi:T265_06617"/>
    <dbReference type="CTD" id="20320796"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="23111" checksum="CC2962903BFABFCC" modified="2014-10-01" version="1">MLHVFVSSSSGNPLVKNKQQYVLNLLSALKIPYKTRDISQCEEDKQFMMKVLRELGKPVIAPQLFLDNEYIGGYDELVEANENEQLSDFLRIPVNRTPHNVHKPACRQSDSRIRCYLWGGGWTKWLKREFTDRKVRGSNPTSATRLPLFGLGQPGSSPALLPSSCGMAVRHILILGLAGERLSPHIHMRSHNYSGLAYFYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG32</accession>
    <name>A0A074ZG32_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glypican</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170046.1">
        <property type="nucleotide sequence ID" value="XM_009171782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG32"/>
    <dbReference type="STRING" id="6198.A0A074ZG32"/>
    <dbReference type="GeneID" id="20320687"/>
    <dbReference type="KEGG" id="ovi:T265_06508"/>
    <dbReference type="CTD" id="20320687"/>
    <dbReference type="OrthoDB" id="10010764at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF30">
        <property type="entry name" value="DALLY-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="666"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120396" checksum="6EFCCDFFECED2C38" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHH8</accession>
    <name>A0A074ZHH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596885">
        <property type="protein sequence ID" value="KER22685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173566.1">
        <property type="nucleotide sequence ID" value="XM_009175302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHH8"/>
    <dbReference type="GeneID" id="20323447"/>
    <dbReference type="KEGG" id="ovi:T265_09274"/>
    <dbReference type="CTD" id="20323447"/>
    <dbReference type="OrthoDB" id="10466201at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8147" checksum="AD26D88A88C2D5CD" modified="2014-10-01" version="1">MAKSLGTLNKKYTHSQISLVGTRDSTESLVYDILQRNVLHTGTIFEISQYISMMESTHKVAENSSTAHDRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHS0</accession>
    <name>A0A074ZHS0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173454.1">
        <property type="nucleotide sequence ID" value="XM_009175190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHS0"/>
    <dbReference type="STRING" id="6198.A0A074ZHS0"/>
    <dbReference type="GeneID" id="20323358"/>
    <dbReference type="KEGG" id="ovi:T265_09179"/>
    <dbReference type="CTD" id="20323358"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="140"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="260" mass="28808" checksum="C5418A0F8057B993" modified="2014-10-01" version="1">MPPPRLASTSAPFNLMPPVNYQTILLSSYFFLIPPLPKLPKSASHGLPTEGELSGTLHRPDSVWLVPLPNPDPAVKGMRIPSPISASSMTLTGLSTNRACFPVFIRIVSSSGVVCTTSPVMSQMNAVSDDYDACELKFPKEFENADTLMLSEVKLLLEHRKEQNESATVHELELSQAFTKTLNYATQLSRFNNRETIESVRSLLSQKRFHGFELAAIANLLPDTAEEAKALIPSLDSSRFTDEELQQLLDEIQSKRSFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIT5</accession>
    <name>A0A074ZIT5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596858">
        <property type="protein sequence ID" value="KER23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172993.1">
        <property type="nucleotide sequence ID" value="XM_009174729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIT5"/>
    <dbReference type="STRING" id="6198.A0A074ZIT5"/>
    <dbReference type="GeneID" id="20322996"/>
    <dbReference type="KEGG" id="ovi:T265_08817"/>
    <dbReference type="CTD" id="20322996"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="553" mass="60573" checksum="EA27D11F74B5EA39" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK03</accession>
    <name>A0A074ZK03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 7"/>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168863.1">
        <property type="nucleotide sequence ID" value="XM_009170599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK03"/>
    <dbReference type="STRING" id="6198.A0A074ZK03"/>
    <dbReference type="GeneID" id="20319740"/>
    <dbReference type="KEGG" id="ovi:T265_05558"/>
    <dbReference type="CTD" id="20319740"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="491" mass="55239" checksum="0FD6E6054F549955" modified="2014-10-01" version="1">MFTGSINLKTKEGCIIRIHKTDGHTKGHRERKSLSSLTQVAANPHIYRCFGSAFTRQMHLVQTTPSFLKKLEQKIAPYRPEYRRAKGIDHSELLVIVAPDAARIPPSLSGYSYGSAICVEIKPKFGAFFLWPSTDSVHTVKSSSGLFCLRQNHSTKQSRWQQLSNYCPCDLFSGDRNRMARSLWALLDTPQINLRIHLDTQLIFSYEVDRLDRGLDSFFWDTTYKTCGGANGLNGLNGVCENGCNEESVHKCKKNRECPFTNDRDRLIRGLLLDALLHELNSENDSSAPISLYPGDRVAFSMNCRFHRALRRAQYPQLDASKVPINGDSSTTSSDQLPPDGSILGRVLATQLLSRVDICFVVPHYERVCECLIANRLTWDDYVGLADSDRTHLLGDSPELVKSFDIVEKYLISLVARDCSIMICLRRALPGCPDWVPTVGNTCACVPRMIMNAVIIDLDPKPLKKIRDRLSVEESIVHQTLAQHPWLLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKJ1</accession>
    <name>A0A074ZKJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172370.1">
        <property type="nucleotide sequence ID" value="XM_009174106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKJ1"/>
    <dbReference type="GeneID" id="20322517"/>
    <dbReference type="KEGG" id="ovi:T265_08338"/>
    <dbReference type="CTD" id="20322517"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="21985" checksum="4D6CBF92EAC88C14" modified="2014-10-01" version="1">MTSTSPATTSTHSAGKTACQPSGLSKFAVSTSTRALSGCGSSPRVQGSGISSGFGVQSGRGEFLPEGEQDGERAPDLRRLGGSAVRNLPADGLIHSRSQTLVVIWYDGTKVISFLKNTTYRSNTGISAGRPRTPPSGTGRPSVVVAGRKAIASTGSMLILARTKCASVSDTRSTRRRRRPSCLACCCCSVVDAAVSDPAASSCRTDWLATAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKX6</accession>
    <name>A0A074ZKX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596826">
        <property type="protein sequence ID" value="KER24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172231.1">
        <property type="nucleotide sequence ID" value="XM_009173967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKX6"/>
    <dbReference type="STRING" id="6198.A0A074ZKX6"/>
    <dbReference type="GeneID" id="20322403"/>
    <dbReference type="KEGG" id="ovi:T265_08224"/>
    <dbReference type="CTD" id="20322403"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="303" mass="33872" checksum="9554C4FF0222928D" modified="2014-10-01" version="1">MHPSTKAVQRPLLLSTLVFVDLETTGLPSSTFKPEITELCMLATSRFSVEQSEVTHIRVQNKLNLCFYPNRTMNAVAARVSGLNKTNLFHQKDFDSTAVKMIQLFVKRLDPPVCFLAHNGNHFDFPLLRAQLCGVKGEEFRLLDCEDSPIICADTLPLFAELNHLLLPRNPGNDSGFDSMDDRTGPDNKVFPLLHSSPKKPSVSFRLGDVYSRVFGSGHAHAHSAEGDCIAMLKLVHHLGLSAVDWLQVHYTDFNSIPPMYRHPLADPPSDPTDFPYKRRLGDSVSSSALKDTVEELSKFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMV5</accession>
    <name>A0A074ZMV5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167512.1">
        <property type="nucleotide sequence ID" value="XM_009169248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMV5"/>
    <dbReference type="GeneID" id="20318675"/>
    <dbReference type="KEGG" id="ovi:T265_04493"/>
    <dbReference type="CTD" id="20318675"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19177" checksum="A1DB7AAAB8133A57" modified="2014-10-01" version="1">MENSKSEQFCPNALSANATVEPLATPDRAEVVPGKPYCGNGVSASSKQKLTATSDRTVSQHNPSLSMTKYKTPAKHRSSLRIQELSVASDKDARVPNTSPGLSITLIFSAKEFQEFQERALDITVISDASNYGIGAVNRVTGTPYWKAYKKNAQTLRDLLLAFLPSHALSSSRFAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN00</accession>
    <name>A0A074ZN00_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Roc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171552.1">
        <property type="nucleotide sequence ID" value="XM_009173288.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZN00"/>
    <dbReference type="GeneID" id="20321879"/>
    <dbReference type="KEGG" id="ovi:T265_07700"/>
    <dbReference type="CTD" id="20321879"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1439" mass="157961" checksum="33AC6DBBBB358155" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP04</accession>
    <name>A0A074ZP04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167391.1">
        <property type="nucleotide sequence ID" value="XM_009169127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP04"/>
    <dbReference type="STRING" id="6198.A0A074ZP04"/>
    <dbReference type="GeneID" id="20318570"/>
    <dbReference type="KEGG" id="ovi:T265_04388"/>
    <dbReference type="CTD" id="20318570"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37328" checksum="ABFF72D1137DCD08" modified="2014-10-01" version="1">MKSMSFKEKRPQPITITSTEVRDMSDSPADSPASPTSGSNQTTKSEEPVKVVVLGSAKVGKTSIIQRFLYNRFESKYIPTVEDMHTKKLIARDHIVRLVLIDTAGSFDFPAMIRLCIDKAHAFILVFSHDNPGSLVQAGIFLNQIKSQRKDYAPLVSTMPHNISEKSSVVAPTSASPIGPGSPPITVVCNKSDLPLSCSRISESVIMEWLLTNGLKPSQFVYASAKSNDSIQAIFKSLWIQNETTKSIQLEPWDNSRRSSIHSVRPQTPTLPATDFSALSGTVQQAEESGDGPNNAESEKTPFKSRPNLFRSSLRLARRTSSKHNKAKPEFEHVDCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR03</accession>
    <name>A0A074ZR03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium bile acid symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168033.1">
        <property type="nucleotide sequence ID" value="XM_009169769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR03"/>
    <dbReference type="GeneID" id="20319091"/>
    <dbReference type="KEGG" id="ovi:T265_04909"/>
    <dbReference type="CTD" id="20319091"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58805" checksum="316F366759172D50" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR52</accession>
    <name>A0A074ZR52_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166629.1">
        <property type="nucleotide sequence ID" value="XM_009168365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR52"/>
    <dbReference type="GeneID" id="20317981"/>
    <dbReference type="KEGG" id="ovi:T265_03794"/>
    <dbReference type="CTD" id="20317981"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10817" checksum="2E8F6EA595945648" modified="2014-10-01" version="1">MFHLHSRLHGPPDSCPNNTIIVCVQPATSQMLFILLWRSSEIPVKLFQDIYRYIWRSLESMTSRCLWSSEKGGEILLVNCKQIDLRLISYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRA8</accession>
    <name>A0A074ZRA8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166312.1">
        <property type="nucleotide sequence ID" value="XM_009168048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRA8"/>
    <dbReference type="STRING" id="6198.A0A074ZRA8"/>
    <dbReference type="GeneID" id="20317723"/>
    <dbReference type="KEGG" id="ovi:T265_03536"/>
    <dbReference type="CTD" id="20317723"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="312" mass="36130" checksum="4F182F80FFDC0E02" modified="2014-10-01" version="1">MAVPFINQDSGILAMVEEGEDQAPRGNTLKLWGNQQTMNLNTMVYTNIVQSPYFKANLIELRTYHEVIDEIYYKVEHLEPWERGSRRVGGQSGMCGGVRGVGAGGIVSTAFCLLYKLFTLKLTRKQLKGLLDHPDSPYIRALGFMYIRYCLPPEDFWWWYAPYLDDTEEIDVKAGGGSMMTIGSMIQHWLTKLDWFGTLFPRIPVPVQKKLEEKLRAHGPAPTLQGPIAPTAHKVISQSVREMDTSNHKKHGHSHKSKHSDRERHRHHGRRSRSRSHERRRSNSPRGRESSFERDLKRARERQERDRRRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRE3</accession>
    <name>A0A074ZRE3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167884.1">
        <property type="nucleotide sequence ID" value="XM_009169620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRE3"/>
    <dbReference type="GeneID" id="20327765"/>
    <dbReference type="KEGG" id="ovi:T265_13598"/>
    <dbReference type="CTD" id="20327765"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF83">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="223"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="542"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1191" mass="136485" checksum="4D10BBBA90290AD7" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRT4</accession>
    <name>A0A074ZRT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL617412">
        <property type="protein sequence ID" value="KER18024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178229.1">
        <property type="nucleotide sequence ID" value="XM_009179965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRT4"/>
    <dbReference type="GeneID" id="20330515"/>
    <dbReference type="KEGG" id="ovi:T265_16350"/>
    <dbReference type="CTD" id="20330515"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8548" checksum="9F660525CDE31EBF" modified="2014-10-01" version="1" fragment="single">CMGQQSLWNSKAMGICSKGRDFKLPMNLSIELRCNHRPTFPLLRNLWRKDNNEIIPTSIPGRLMTIHRKLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSI9</accession>
    <name>A0A074ZSI9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ribonuclease Z</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_03450</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166198.1">
        <property type="nucleotide sequence ID" value="XM_009167934.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSI9"/>
    <dbReference type="GeneID" id="20317637"/>
    <dbReference type="KEGG" id="ovi:T265_03450"/>
    <dbReference type="CTD" id="20317637"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ENTH" evidence="17">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1347"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1421"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="343"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1347"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1421"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER30086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1455" mass="160944" checksum="659CC66F3CF6DADE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSN6</accession>
    <name>A0A074ZSN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604564">
        <property type="protein sequence ID" value="KER18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177974.1">
        <property type="nucleotide sequence ID" value="XM_009179710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSN6"/>
    <dbReference type="STRING" id="6198.A0A074ZSN6"/>
    <dbReference type="GeneID" id="20330332"/>
    <dbReference type="KEGG" id="ovi:T265_16167"/>
    <dbReference type="CTD" id="20330332"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="41" mass="4727" checksum="B6BDAFEC56673E47" modified="2014-10-01" version="1" fragment="single">MKTVIARNLAEKRPSVRLLIARLRVEPETSSAHEQRERIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT29</accession>
    <name>A0A074ZT29_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
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        <property type="protein sequence ID" value="KER30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166021.1">
        <property type="nucleotide sequence ID" value="XM_009167757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT29"/>
    <dbReference type="STRING" id="6198.A0A074ZT29"/>
    <dbReference type="GeneID" id="20317498"/>
    <dbReference type="KEGG" id="ovi:T265_03311"/>
    <dbReference type="CTD" id="20317498"/>
    <dbReference type="OrthoDB" id="6225866at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="451" mass="50359" checksum="DEF30A337E76BEC3" modified="2014-10-01" version="1">MTDDRVVRWLNEIRVLDGGVGSECQKRSHLPIDGHKAWSCRLLKEDPNLVCEVHKSYLRAGCDVLSTNTYQASPPTLAKALKISDSEARELMRHAVRLVRRAIATTDEESFASNTHQWKNRKLPVLVAGSLGPYGACLADGSEYSGSYADRMTFDELVEFHYARAKILVDAGADFLAWETIPILMEVVAIVEVMRRLPQSLAWLSVASSNGQTTVGGDPLHQVALEIQKCDQIFGIGVNCCIEHDKIGLALSNLNIGQDGCGPGTDDGYHPPPCSKRPDHLDKLSTKPRKLLVLYANSGEMWLPPPKGLSRRRGRWVWPPNKGPSVWARTIVQFSMRRCADWEKELLNGVAVRLSDPEAVYPKAQWVGGCCRVGPMEIRHLAILMKPDEVQNIFLETALTSSSVQSPASTVLFRRQSARNKRRLPGNYRRRIQPPRAVKTRHSVGHNQEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU26</accession>
    <name>A0A074ZU26_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166913.1">
        <property type="nucleotide sequence ID" value="XM_009168649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU26"/>
    <dbReference type="GeneID" id="20327547"/>
    <dbReference type="KEGG" id="ovi:T265_13380"/>
    <dbReference type="CTD" id="20327547"/>
    <dbReference type="OrthoDB" id="6280584at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8660" checksum="59DDBC92EA3F82AE" modified="2014-10-01" version="1" fragment="single">MFAKTNRIRSKPIFCTPNHRYFNACDWPESKPVQPLMTCNSFGQTSEFILKVSQFSELNYVPNFRRGYPIYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUI8</accession>
    <name>A0A074ZUI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165431.1">
        <property type="nucleotide sequence ID" value="XM_009167167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUI8"/>
    <dbReference type="GeneID" id="20317011"/>
    <dbReference type="KEGG" id="ovi:T265_02823"/>
    <dbReference type="CTD" id="20317011"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34719" checksum="2E27A5BF4079E40B" modified="2014-10-01" version="1">MIRRTIKSLRCVLAGMFGENLKENPRVEPAVINVEPLDREYLFPNPVICKSVDRFAKDGMSECLNSESHRRLKQKLKSVLGVKKLYDDFRPTPWDCPVYFVRDDYMSRKSANYPLPPGMDELLPTMHQLAAEELYWEYLGMKHHWDENLHVVMSGVLKMILCSMRHFTRVPKFQLYSCHDSTLMLLLYALECFDGYWPPFAADLILELYVDENVVKILTEGDSSPQADNNNRRLSDLQYTPLDALWIKVSYLGQVVPLGCLWKTPYTDAGRYNMGYVPLRFLLERWSSSAPSFEDLALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUR0</accession>
    <name>A0A074ZUR0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165019.1">
        <property type="nucleotide sequence ID" value="XM_009166755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUR0"/>
    <dbReference type="STRING" id="6198.A0A074ZUR0"/>
    <dbReference type="GeneID" id="20316680"/>
    <dbReference type="KEGG" id="ovi:T265_02492"/>
    <dbReference type="CTD" id="20316680"/>
    <dbReference type="OrthoDB" id="10386064at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="221" mass="24149" checksum="1B3D09F133B00D1C" modified="2014-10-01" version="1">MSQPTQLLVLDTFFNGSTRYTTENTLSNCLVTDSPTPTHASYGSETTIVEHLKTSQVRCSNRPILTAIQQNSPYCSSIHTCLKLANANRALQVHAFTSSVTLHSELIQLPRYVKRSTTSSASPWIVSGVFSDCTSTSMTLHFVGAKCIPKDGMTLVSLDLLGLDWINELRLLDEPLSAVCDKTTANGPDTPTRTSPPDDFVIATVTAKPETRWSIRDTANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV72</accession>
    <name>A0A074ZV72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deubiquitinating enzyme A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165168.1">
        <property type="nucleotide sequence ID" value="XM_009166904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV72"/>
    <dbReference type="STRING" id="6198.A0A074ZV72"/>
    <dbReference type="GeneID" id="20316794"/>
    <dbReference type="KEGG" id="ovi:T265_02606"/>
    <dbReference type="CTD" id="20316794"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22752">
        <property type="entry name" value="OTU_OTUD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF4">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="9">
        <location>
            <begin position="209"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="61797" checksum="0FC2F8CD153679A8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWB4</accession>
    <name>A0A074ZWB4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164818.1">
        <property type="nucleotide sequence ID" value="XM_009166554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWB4"/>
    <dbReference type="STRING" id="6198.A0A074ZWB4"/>
    <dbReference type="GeneID" id="20316528"/>
    <dbReference type="KEGG" id="ovi:T265_02340"/>
    <dbReference type="CTD" id="20316528"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="440" mass="50013" checksum="A207994159484C1C" modified="2014-10-01" version="1">MFLLHHDFLYDAQSRFTALYIIWDMYKSDPRYLNPFLGFLVSYLQDDTMSKLPWSAVLVLHTILSQPDQINEFLKYTPMEILNLRVNNTSRKPDWSALQTELQALIEKLPKVASCGIPCVVPDKDVPSSFYSEESTPIQLRRHCLDSLLSRTEPFSCQDGLRPEFIRVAPPLLPCPQGNGIPRILTKDDEAEDSCSSADNRTVEKRQTNVFSGWHEELIWLNPPTIVHDFHWDVDDEQAAPITELRTLLNKAMNSTLQQSDQQTIVQMISENPNLVHSLGINVENLPNLVNRNPVIAIEILAVLVDSPKAEEFYDALVSMEVTVDSLEVVNRLATRVSLPKEFIQSYISRCMTYCQSLQDKSTQQRNVRIVCVLIQSFIRNKILDIHNENILIEVQRFCVEFNKVPGANPLYRTIKNMESSTSGTSQSSTSGNPTDSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXF9</accession>
    <name>A0A074ZXF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_12905</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164477.1">
        <property type="nucleotide sequence ID" value="XM_009166213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXF9"/>
    <dbReference type="STRING" id="6198.A0A074ZXF9"/>
    <dbReference type="GeneID" id="20327073"/>
    <dbReference type="KEGG" id="ovi:T265_12905"/>
    <dbReference type="CTD" id="20327073"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="81"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="23570" checksum="8DF26AEC6F80A8B2" modified="2014-10-01" version="1" fragment="single">MTDFTCQTSEDETYDWLEAEEAEDPEYAEQLRRYSMWLQPKAESLIPQTAFWSACRRDLADRLHSMPVNIAIIALASLDALILICVMLLEIEALKLEPGEKQTILQEARFALECVSVCILSVFTMELTLKLIAVGPRHFFTQWLEVLDACVTIVSLVIDAVVIADHAIHMQNSHGDSHESGLGIGRGALDAFGAAAGLLIVFRLWRVVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXL8</accession>
    <name>A0A074ZXL8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165660.1">
        <property type="nucleotide sequence ID" value="XM_009167396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXL8"/>
    <dbReference type="STRING" id="6198.A0A074ZXL8"/>
    <dbReference type="GeneID" id="20327313"/>
    <dbReference type="KEGG" id="ovi:T265_13145"/>
    <dbReference type="CTD" id="20327313"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
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    </dbReference>
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    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="143"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER30657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="610" mass="70983" checksum="7B2B9B39EFECDDA4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXZ6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_15402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20064.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009177927.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_15402"/>
    <dbReference type="CTD" id="20329567"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="8908" checksum="768CF99EBD8C0498" modified="2014-10-01" version="1" fragment="single">MKSKERNQKLSNGRPDTASTINNPSHCSLGARAPELRILTDITSYYSTNQYSRPTNKESGKSHHQTINIFRVTGRKTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY21</accession>
    <name>A0A074ZY21_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009177897.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZY21"/>
    <dbReference type="GeneID" id="20325449"/>
    <dbReference type="KEGG" id="ovi:T265_11281"/>
    <dbReference type="CTD" id="20325449"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="1780"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="632"/>
        </location>
    </feature>
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        <location>
            <begin position="858"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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        </location>
    </feature>
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        <location>
            <begin position="2046"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2060" mass="231261" checksum="865FC286F329BE99" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYA5</accession>
    <name>A0A074ZYA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
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        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 75 kDa subunit family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165583.1"/>
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    <dbReference type="KEGG" id="ovi:T265_12805"/>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="595"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="13">
        <location>
            <begin position="673"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="864" mass="93895" checksum="CD072E51DF5BBB25" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYN7</accession>
    <name>A0A074ZYN7_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER32156.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYN7"/>
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    <dbReference type="KEGG" id="ovi:T265_01770"/>
    <dbReference type="CTD" id="20315958"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6895" checksum="67AEB8AC71C3428A" modified="2014-10-01" version="1">MSSCLLGQHEFGYWTSDVPLVLDLDVIPYFEELNKSMRTIQLSSSRAPRMSLARLDILLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYP5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32161.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYP5"/>
    <dbReference type="GeneID" id="20315965"/>
    <dbReference type="KEGG" id="ovi:T265_01777"/>
    <dbReference type="CTD" id="20315965"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11266" checksum="273699E40B5EF09E" modified="2014-10-01" version="1">MKRLLRHRFGEQRGETKKSTQCNKRLLSSPTVYKERPGALRRVRQVAGGHYPPTKLESSRSNRAPHYLSSAPTKLGQCCEEIDGPTLKSFDFLGAQRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ23</accession>
    <name>A0A074ZZ23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163882.1">
        <property type="nucleotide sequence ID" value="XM_009165618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ23"/>
    <dbReference type="STRING" id="6198.A0A074ZZ23"/>
    <dbReference type="GeneID" id="20315747"/>
    <dbReference type="KEGG" id="ovi:T265_01559"/>
    <dbReference type="CTD" id="20315747"/>
    <dbReference type="OrthoDB" id="420169at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16784" checksum="078BED1991059A05" modified="2014-10-01" version="1">MRTQSTSFASGELALENTARRTVYIILLDIHRKIAAISAPPHKLAHKDRKFSQTVGCDEVFNHLKKAPAPILKYPDLSDAEEFVLNTDINLSLTTVTQREMLALVYFFQHFQPYLLGWHFLVSTEHHLLQCLQSYHDPYCQVSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZY6</accession>
    <name>A0A074ZZY6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175558.1">
        <property type="nucleotide sequence ID" value="XM_009177294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZY6"/>
    <dbReference type="GeneID" id="20324983"/>
    <dbReference type="KEGG" id="ovi:T265_10815"/>
    <dbReference type="CTD" id="20324983"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7959" checksum="0E67AF3B2F193B47" modified="2014-10-01" version="1">MDEQGKRSAYKRRATQQQVNKPQQKEIAERGTEQGEKIHDWNTLELIHVRPFDRKLSGSTRTILRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A033</accession>
    <name>A0A075A033_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163614.1">
        <property type="nucleotide sequence ID" value="XM_009165350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A033"/>
    <dbReference type="GeneID" id="20315532"/>
    <dbReference type="KEGG" id="ovi:T265_01344"/>
    <dbReference type="CTD" id="20315532"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="16003" checksum="F56CD5B526E1DEC9" modified="2014-10-01" version="1">MKTIQKINARIHEADCRSYCRIPALGTKSPPNISKALYTRYIWYSVFMVNLHLSTASKEGIATTPVFNTVGYAERKNRLLNFLLRNESSALTKSSSNSAGENLRRQKRVQLQEVDSFICDLGSFRSLDKKKRAKFGIPKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A063</accession>
    <name>A0A075A063_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiamin pyrophosphokinase thiamin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163447.1">
        <property type="nucleotide sequence ID" value="XM_009165183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A063"/>
    <dbReference type="STRING" id="6198.A0A075A063"/>
    <dbReference type="GeneID" id="20315386"/>
    <dbReference type="KEGG" id="ovi:T265_01198"/>
    <dbReference type="CTD" id="20315386"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="5">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28520" checksum="F68F8285AB7D67C6" modified="2014-10-01" version="1">MYKYEDPSRTPQNLWLDIDDERGQEPNHLLIYTTILRLNDFHATFCFTTKYTCCSTQYIRTDARKALIFLNSADSTLHPLFKGIWVNSFVDGFANQVFCLPDKECYIPDFVTGDFDSISGDALSYYRSQDKPAAIAVVHMSGGRLDHEFGLIQTLYEAHRMNSIPVHLVSECCVSILLPAGMHQIHTNTGLEADHCGLVPVGAPSLVTTTGLKWNLRNQLLSFGHLVSTSNQLAAPLIEVTCDSPLLMILEYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0X7</accession>
    <name>A0A075A0X7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596997">
        <property type="protein sequence ID" value="KER21064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175192.1">
        <property type="nucleotide sequence ID" value="XM_009176928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0X7"/>
    <dbReference type="STRING" id="6198.A0A075A0X7"/>
    <dbReference type="GeneID" id="20324701"/>
    <dbReference type="KEGG" id="ovi:T265_10533"/>
    <dbReference type="CTD" id="20324701"/>
    <dbReference type="OrthoDB" id="5853681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="480" mass="54669" checksum="0FF97CDBBA459939" modified="2014-10-01" version="1">MYRDISNIVATETRGGLAQHIQLPGHITNERFSWVLFETKFTIEQGSKTLICNLVTKTGHRSSPERVFLEIHCLQSFVCQIKANVTKWPREFRNRIPFFNRRKAKFYEQHILLACPPISILNNSEDFYYGIVGIGTPPKEFRLLFDTGSPILWVHSKNARHDLRPFKNTFDPYGSSTFVDSTTEFKAKYANFEVYGFVSTDILQVLMDKYGYINKQIGGRSLSGTFGPVLLFKGQPTQHSWNDGILGLGRRQAYSQFKTMFVDQLFEQGLITRRTFAFVFCRYPPRKATVIFGEITKDHIPGDVSFVKVSKTEQFPYHWVVLVNRIELSIGGTLATGVHALVDTGTPMSYLPADLTTRLYALIGVRQQATRNVVDCNRIPSMPTLRFNFGSFELLLESQQYIFVVILGLSLPSYRSRQNNHQSCTRSINTKNEVKNSCTALRIYSVSGYNFLEFLTRSGAPLATGIWPILGHDWLLGPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A137</accession>
    <name>A0A075A137_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163153.1">
        <property type="nucleotide sequence ID" value="XM_009164889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A137"/>
    <dbReference type="GeneID" id="20315162"/>
    <dbReference type="KEGG" id="ovi:T265_00974"/>
    <dbReference type="CTD" id="20315162"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17617" checksum="CA3506111F558861" modified="2014-10-01" version="1">MGVQKRAASVPDVSRLLQAQLHYLWRQHCSTNKRWDPPIVILLTYRFCIASGGEERSVKIDETCQPYIPCTTNATITRWDIGENEFSVLSVRVIDYFIGIAVSVLVQLKDRLPVDGTTNCVYKIKCNDCTKIYIGLTGNSTPESVSISDPLTDHPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A167</accession>
    <name>A0A075A167_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_10467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175110.1">
        <property type="nucleotide sequence ID" value="XM_009176846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A167"/>
    <dbReference type="STRING" id="6198.A0A075A167"/>
    <dbReference type="GeneID" id="20324635"/>
    <dbReference type="KEGG" id="ovi:T265_10467"/>
    <dbReference type="CTD" id="20324635"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="920"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="691"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER21134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124022" checksum="8C63D1A81EDD740C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2J3</accession>
    <name>A0A075A2J3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase, family 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163828.1">
        <property type="nucleotide sequence ID" value="XM_009165564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2J3"/>
    <dbReference type="GeneID" id="20315711"/>
    <dbReference type="KEGG" id="ovi:T265_01523"/>
    <dbReference type="CTD" id="20315711"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52694" checksum="3C704B9E21FE69C8" modified="2014-10-01" version="1">MFPKIDRNPKPYAIHLVHDTLARSITLLKSVLYYRGSLRSKRPECYLRRIPSPHLCAKQRVIERIAIHLHLVVEQRLLSAAYSYVSQWRVAQFNWTVYELDPYLPRVKWISNKHRSGVAALSKMLIPDVLPTNVTKAIVLDTDILLNADILELWKLFDNFDQHQIFGMAWEFDSVDAKCNKIRIPQMIQSDSTHSATDLPFQETQSEFPRTTHTTRKPPSVETVVVRSLSIDKFGGRDPTDDTTVSSSIVQWLAEKNGVNSGVVLMHLSRMRKAKWSTLFEWAVHKVLLIDGTLLVGEQIQTGILTKAHHGQYSNKHRHILINVYAIASTRAQNQHAHTRWSHPISSVIHICFHGKSALNVLIQRRPELYYRIPCEWNLQLFPEAAQIFCPVIWTDRLSEEAICSEYESPKHGDLAHPGIPNLVHCNFSPGKPESGGNAPSSFRASLNASKAQTSKALRCSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A310</accession>
    <name>A0A075A310_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596942">
        <property type="protein sequence ID" value="KER21774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174482.1">
        <property type="nucleotide sequence ID" value="XM_009176218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A310"/>
    <dbReference type="GeneID" id="20324149"/>
    <dbReference type="KEGG" id="ovi:T265_09981"/>
    <dbReference type="CTD" id="20324149"/>
    <dbReference type="OrthoDB" id="10050666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="7185" checksum="6BE00607C53A0AEC" modified="2014-10-01" version="1" fragment="single">CFPLKLFRQSKGRWVYNGMLKRMNFASPLYTSGWPQVSYLTQVFGKRLVKEYIPLLQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A317</accession>
    <name>A0A075A317_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 25 member 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166227.1">
        <property type="nucleotide sequence ID" value="XM_009167963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A317"/>
    <dbReference type="STRING" id="6198.A0A075A317"/>
    <dbReference type="GeneID" id="20317650"/>
    <dbReference type="KEGG" id="ovi:T265_03463"/>
    <dbReference type="CTD" id="20317650"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45160" checksum="DA7F71BA3DC85C5C" modified="2014-10-01" version="1">MTTKDDEFEVIELSMLDKRKFYPLSGLGSFTVHSMLYPLVLLRIRLQLQEGAHLYTGLAHATSCILREEGFRGLYSGYFVKSAQIISSVFYASTYETVRHMSSGIPGLSQTQRSFIGGGVASMLLQTVLVPVDVISQHLMVLSRTSSISPCSSAAPQSIAPSVKLKSKSSGQSVMTDVRLEQVRALSPIRLSSSELSTSWARFRAVTSYVAHKHGIRGFYNGYVISLFTFVPSSAMWWGFYDKFCRLIASTVSKLDDTLFASNATNSSGSPLVPRLAVQLIAAPLAGIASATLVNPIDCVRVRMQLDDTLFASNATNSSGSPLVPRLAVQLIAAPLAGIASATLVNPIDCVRVRMQDAIDNVSFIWTSSLNEDAVRRICLARSVVGRRVNGEIKRLLNCKQFVDHYWLSWGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A352</accession>
    <name>A0A075A352_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAD superfamily hydrolase, 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162535.1">
        <property type="nucleotide sequence ID" value="XM_009164271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A352"/>
    <dbReference type="STRING" id="6198.A0A075A352"/>
    <dbReference type="GeneID" id="20326715"/>
    <dbReference type="KEGG" id="ovi:T265_12547"/>
    <dbReference type="CTD" id="20326715"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF15">
        <property type="entry name" value="CYTOSOLIC PURINE 5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="2"/>
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    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69830" checksum="7576755B93FA3409" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3S0</accession>
    <name>A0A075A3S0_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009167829.1"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="438"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER30175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="438" mass="49655" checksum="6787938A106F2C5A" modified="2014-10-01" version="1" fragment="single">LRVEFTGTYGDFLFSCSNLSLPSCRGARRRPEGRDTARLPKRRQGKSRGRGRVRTTELPSLTRSRDSSFLHSQITPYNCDSSDIDCRCRQVSVATSHALTPTYTQTCLHIGKPSTVSTQTCARARSRTTTTLHNPTELWNTCSSYTAEKTRSGRQDFHQETLTNDNTTYPINPSRERIPDIVLKLCRRKQIRRKGRPSYAPMMSLGLVTKRLQANCQARRTNQQPLGQPPVSEIGRGRSATKIHVQRTARTDCPVRLTSELAVISARLSVLTTSNIFKSIFKSPHPVYRATFNVRALKQDNKLLLLSHWTRLTMMRDVYQKRIQNKTAAAELIVPTDGMCDTVNFNFSDVFSFPLEWIAEGLDAQVSRLSASDIHSAGRIGLNSVSEDNRKRVLQLRADRSYLYATWCPSTEHKPRIQIDQVAINYRWYGSPTDGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A468</accession>
    <name>A0A075A468_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165900.1">
        <property type="nucleotide sequence ID" value="XM_009167636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A468"/>
    <dbReference type="GeneID" id="20317404"/>
    <dbReference type="KEGG" id="ovi:T265_03217"/>
    <dbReference type="CTD" id="20317404"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="16248" checksum="D3AB23A28B3B030B" modified="2014-10-01" version="1">MDLFTGVKYDTCSILCQTNNKVAKKVTSGISPFSGYKKGHQSRIPEENVAERTTDCGLSEHPSYLDFYRAREDIQYSDQRIDEIALTHPAWFRIDFPPLLLDAFQHRAVSRMFSGEQKIEGNERNLKDMEMKNQRPSTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4F2</accession>
    <name>A0A075A4F2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_09604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173983.1">
        <property type="nucleotide sequence ID" value="XM_009175719.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A4F2"/>
    <dbReference type="GeneID" id="20323772"/>
    <dbReference type="KEGG" id="ovi:T265_09604"/>
    <dbReference type="CTD" id="20323772"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF1">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1309"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1452"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1507"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM SLOG" evidence="10">
        <location>
            <begin position="92"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="11">
        <location>
            <begin position="409"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="TRPM-like" evidence="11">
        <location>
            <begin position="584"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="926"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1544"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1750"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1842"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1931"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1983"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2083"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2243"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1562"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1842"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1877"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1900"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1983"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2013"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2090"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2107"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2249"/>
            <end position="2267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER22279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2275" mass="254644" checksum="E81C3634AD8D6560" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5C9</accession>
    <name>A0A075A5C9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165452.1">
        <property type="nucleotide sequence ID" value="XM_009167188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5C9"/>
    <dbReference type="STRING" id="6198.A0A075A5C9"/>
    <dbReference type="GeneID" id="20317032"/>
    <dbReference type="KEGG" id="ovi:T265_02844"/>
    <dbReference type="CTD" id="20317032"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="315"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="794" mass="87764" checksum="99F5D96DFD2E9F33" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A606</accession>
    <name>A0A075A606_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165181.1">
        <property type="nucleotide sequence ID" value="XM_009166917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A606"/>
    <dbReference type="GeneID" id="20316807"/>
    <dbReference type="KEGG" id="ovi:T265_02619"/>
    <dbReference type="CTD" id="20316807"/>
    <dbReference type="OrthoDB" id="6251906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13551" checksum="1EAE05480061B3D2" modified="2014-10-01" version="1">MASEETQALEVDNVIYVKLPEFGSRDPRLWFAQLEAIFESRRITSQNSRYNHVVGCLPDFIAREVSDLIYSRPPTDPYDVLKSAIISRTGASDEQNLRKLLSGVDFGDKSPSQHLHHMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8R3</accession>
    <name>A0A075A8R3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172363.1">
        <property type="nucleotide sequence ID" value="XM_009174099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8R3"/>
    <dbReference type="STRING" id="6198.A0A075A8R3"/>
    <dbReference type="GeneID" id="20328700"/>
    <dbReference type="KEGG" id="ovi:T265_14534"/>
    <dbReference type="CTD" id="20328700"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8365" checksum="2F3ACD4D6ABD7C94" modified="2014-10-01" version="1" fragment="single">MESYFVNQRETIFRNVEVLIYVFDIDNYEVAKDLNYYRSCLEAVNQNSPGARIFCLIHKMDLVPENKQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8S1</accession>
    <name>A0A075A8S1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="8">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KATNA1</name>
        <name evidence="12" type="ORF">T265_08318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Microtubule organizing center</location>
            <location evidence="8">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle pole</location>
        </subcellularLocation>
        <text evidence="8">Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172348.1">
        <property type="nucleotide sequence ID" value="XM_009174084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8S1"/>
    <dbReference type="STRING" id="6198.A0A075A8S1"/>
    <dbReference type="GeneID" id="20322497"/>
    <dbReference type="KEGG" id="ovi:T265_08318"/>
    <dbReference type="CTD" id="20322497"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000003">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="333"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="598" mass="65732" checksum="C1BCAAAAEB090A48" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A994</accession>
    <name>A0A075A994_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164045.1">
        <property type="nucleotide sequence ID" value="XM_009165781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A994"/>
    <dbReference type="STRING" id="6198.A0A075A994"/>
    <dbReference type="GeneID" id="20315903"/>
    <dbReference type="KEGG" id="ovi:T265_01715"/>
    <dbReference type="CTD" id="20315903"/>
    <dbReference type="OrthoDB" id="6614841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="351" mass="39745" checksum="AB75DEFF63DFCFC3" modified="2014-10-01" version="1">MSVLNFIARIDWRRRSKFGVDMYESSFFFFLGLSYGFVQIGVQQFKVMFDTGGFSRWIPSSRSAADHFPNRVKYDENSPTRTSLEKQYVVSYSGEQYEGNVVMDNILIAGQSVEQFTLNEMICSSITVDASVGHDGIFGMSKPSKGPMGKEIFEVNLLDHFLAVGTVQEAVFTFRFCGQPGMRRFSWFVNGDLIFGGVRDEFHHLPIVYLPTYQSKQWMVYIDSIVYGDVILCMSCYALLDTGTPGTRAPGKALQMLLQDSVVEVYDAAVLHVPHQRLPYLLPITINLRSHAFTLHPEQLVRPVGNVYVFAIDGTQDASENNWLIGISFLRHFHTIFDQQNNRVGFAAVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABK9</accession>
    <name>A0A075ABK9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163103.1">
        <property type="nucleotide sequence ID" value="XM_009164839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABK9"/>
    <dbReference type="STRING" id="6198.A0A075ABK9"/>
    <dbReference type="GeneID" id="20326825"/>
    <dbReference type="KEGG" id="ovi:T265_12657"/>
    <dbReference type="CTD" id="20326825"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22847" checksum="E0C37B329A985FF1" modified="2014-10-01" version="1" fragment="single">SFRSLIPNYIRDSAVSIVVYDVTSRDSFDRTIEWIRKIRDERDTSSLIFLVGNKVDLEEERVITTEEGIELAKKEGIFFLETSAKSNIGVQRTQQPGLLLPITFQDSSRLQKDYLACIETNMKIWFLHDWDGVGLSYDLLESLFTTHFQSVAPDVLNPLVGHLNHGSFIIVEDGVKGLADMQAARTEWPFKVATHSIQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADJ0</accession>
    <name>A0A075ADJ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162018.1">
        <property type="nucleotide sequence ID" value="XM_009163754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADJ0"/>
    <dbReference type="STRING" id="6198.A0A075ADJ0"/>
    <dbReference type="GeneID" id="20314285"/>
    <dbReference type="KEGG" id="ovi:T265_00097"/>
    <dbReference type="CTD" id="20314285"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="282"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="567" mass="61469" checksum="AA7FF3C06B18D2C6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE85</accession>
    <name>A0A075AE85_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169675.1">
        <property type="nucleotide sequence ID" value="XM_009171411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE85"/>
    <dbReference type="GeneID" id="20320385"/>
    <dbReference type="KEGG" id="ovi:T265_06203"/>
    <dbReference type="CTD" id="20320385"/>
    <dbReference type="OrthoDB" id="6239008at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12471" checksum="B207079CA837530B" modified="2014-10-01" version="1">MSAAPDWKADLAAKRRQRERETDVERRWQDVMDKNGEGAPEWLKEAAMKKKAMQKQDDGLVPWMREVKRTNKDLARKIAEVHQAEKEAAEVTAAQQPPITAKETTIQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF23</accession>
    <name>A0A075AF23_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168942.1">
        <property type="nucleotide sequence ID" value="XM_009170678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF23"/>
    <dbReference type="GeneID" id="20319801"/>
    <dbReference type="KEGG" id="ovi:T265_05619"/>
    <dbReference type="CTD" id="20319801"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11548" checksum="0BDB822457FBD1F7" modified="2014-10-01" version="1">MKRLQPNCPAQRTSQRPSTLPELPTFSSIEFLKCFLLQGSRPWFAKWRLIDLIIRIRIRMIDSMISVFNADASLPYNRDLFETIIMNLRMKMNRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFN6</accession>
    <name>A0A075AFN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168264.1">
        <property type="nucleotide sequence ID" value="XM_009170000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFN6"/>
    <dbReference type="GeneID" id="20319265"/>
    <dbReference type="KEGG" id="ovi:T265_05083"/>
    <dbReference type="CTD" id="20319265"/>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="27406" checksum="8457C472955D643B" modified="2014-10-01" version="1">MGQVSPSESAFRSCVKMVVSQPMNPSGSHLAAAFTGASLPFERNSSPPARSRDAPKLTQVAGSKGAISDRTKIFKQDAKPNLTQVASEYARQKQMFGLTGLPVKRKRGRPREYTTLTVFQTPPATRSSQHSGVSTARNSMPSFSYTTATPGSQPTQSATTPTIASSTVMPTLSIYTPLTVGAPLPELYSAGLLLPGPNMPLNNLDTAVTRTDSPVTGNVYSSSTSYTLAMTVSSQHVWLRNAQFTPRNSSRIHTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFQ9</accession>
    <name>A0A075AFQ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168235.1">
        <property type="nucleotide sequence ID" value="XM_009169971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFQ9"/>
    <dbReference type="GeneID" id="20319242"/>
    <dbReference type="KEGG" id="ovi:T265_05060"/>
    <dbReference type="CTD" id="20319242"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7450" checksum="21334EAA6CBE7492" modified="2014-10-01" version="1">MSQTTVVLPKYHGRVTTSPGQGRVARLYNPVIDLDLTLYSITPDFRFRLNTRTTDESPRAPDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH17</accession>
    <name>A0A075AH17_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167035.1">
        <property type="nucleotide sequence ID" value="XM_009168771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH17"/>
    <dbReference type="GeneID" id="20327584"/>
    <dbReference type="KEGG" id="ovi:T265_13417"/>
    <dbReference type="CTD" id="20327584"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19544" checksum="A6530CE0CCABFC82" modified="2014-10-01" version="1" fragment="single">MVTLGMRHSQHIYFSNVWARPDKCLEFCGQNWGALTKHVCGSKTSRVIFIKETIHKVAENSSTAQDRFRPSWDSSGRHSPRVSVNLMIYLNQNWTAFEKYTHLQINLVFTRDSTEAPVYVFLLLGTNKTTKGANAFHELRKYLRAMAHRETFSSDGAPVVSSFSPTPLALCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH60</accession>
    <name>A0A075AH60_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 99</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166830.1">
        <property type="nucleotide sequence ID" value="XM_009168566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH60"/>
    <dbReference type="STRING" id="6198.A0A075AH60"/>
    <dbReference type="GeneID" id="20318145"/>
    <dbReference type="KEGG" id="ovi:T265_03959"/>
    <dbReference type="CTD" id="20318145"/>
    <dbReference type="OrthoDB" id="10262255at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039341">
        <property type="entry name" value="CFAP99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34649:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="58496" checksum="67EF1BD11B46DA5E" modified="2014-10-01" version="1">MDEIGLKGLRKILQLTSSQVAVALLKVFTSEESQIKLKEAWSHLYGEEFVENLLVKSFERWQPMLKQFSETYEASLQKKKSQSETKRTTVCRPFKLTQPLPRGIPIPWPIANMEKARPVPRSVFAQPKEFQNIEEQKKQNRERIKELCLESDAKQPSCARLSKRKKKKPEFYRSSMFKAQPVKRVNNKADVRLNTASIVREWEVYKKIEEEQEKKFCDLEAGAFDCIAYKSWRSEQEKRKISDRQALAEKLRLSSLLSRESAFHAKRKLLQEKRINASSLEEESHRLQEQLERTNKAELIKASSVAKIVKANRRGVRLAARKVQVDKRNTAKLVDYEKQRDHEKINEQLVEDRRRKASIIKRIRSEEEAWLLQKENYPKPYDPTDIPGHGLLSEMSLAELKERLFLLRQQNSITLADKINDIKCQRQTKSENITELQKLISCFRNAKTTSRKRQKNCEGGKEDLYDSHPELKDLAQLLLKRRRERQELQSAKALVKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHH5</accession>
    <name>A0A075AHH5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166392.1">
        <property type="nucleotide sequence ID" value="XM_009168128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHH5"/>
    <dbReference type="STRING" id="6198.A0A075AHH5"/>
    <dbReference type="GeneID" id="20327454"/>
    <dbReference type="KEGG" id="ovi:T265_13287"/>
    <dbReference type="CTD" id="20327454"/>
    <dbReference type="OrthoDB" id="5950413at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026146">
        <property type="entry name" value="Ribosomal_uS3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21244:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14955">
        <property type="entry name" value="MRP-S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="18504" checksum="11825BB9AEE3F50E" modified="2014-10-01" version="1">MTLPGRNFLTGVARTFHSSRLVCKNTRVGVVRRTRNQSIPLTYEQAKKPHQIGLMKSWNSWNTSNLENESLYTPDITVQDELIRAFIRGTFPVAVESEVIIKRQWNVVRIAFLLSSRVQPIEAHFLIGYSEEMLSHLLRCMVKLEVQVIASKKDVVFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHK5</accession>
    <name>A0A075AHK5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166212.1">
        <property type="nucleotide sequence ID" value="XM_009167948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHK5"/>
    <dbReference type="STRING" id="6198.A0A075AHK5"/>
    <dbReference type="GeneID" id="20327414"/>
    <dbReference type="KEGG" id="ovi:T265_13247"/>
    <dbReference type="CTD" id="20327414"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="17255" checksum="E104855B5A21F18E" modified="2014-10-01" version="1" fragment="single">VDTLSKSELEELQVAFTAYDKDGNGSIDVRELEEALSRVGRRPTRLEVANIMRRFDSDGDGRINFPEFIVMVMKKKKFASVEADLRRSFNYFDRNGDGFISQEELRSVIRLFGDKLKNLDAEAIMNEADENGDGLLNYEEFLTLMSECYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJC1</accession>
    <name>A0A075AJC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163192.1">
        <property type="nucleotide sequence ID" value="XM_009164928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJC1"/>
    <dbReference type="GeneID" id="20315201"/>
    <dbReference type="KEGG" id="ovi:T265_01013"/>
    <dbReference type="CTD" id="20315201"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="13957" checksum="BB1841BCC0388AAB" modified="2014-10-01" version="1">MCVVQTIKTFWIEEAASVPSISEEDENYCYMGCCPITNNEEVSPQKDNHRSVCGSCGCTPLNACEQAVPPIMDTVCYTKSAHPSVEVCAHVRYTKGVRKKNVLGNPNCTLDITRHSRGVLVLGWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJD7</accession>
    <name>A0A075AJD7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="13">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_00897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="13"/>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163056.1">
        <property type="nucleotide sequence ID" value="XM_009164792.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJD7"/>
    <dbReference type="GeneID" id="20315085"/>
    <dbReference type="KEGG" id="ovi:T265_00897"/>
    <dbReference type="CTD" id="20315085"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
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    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
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        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CATATPASE"/>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="83"/>
            <end position="99"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="348"/>
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            <end position="1133"/>
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        <location>
            <begin position="1562"/>
            <end position="1581"/>
        </location>
    </feature>
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            <begin position="33"/>
            <end position="77"/>
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    </feature>
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            <begin position="1059"/>
            <end position="1151"/>
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        <ligand>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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                <person name="Tan P."/>
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                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <submittedName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597543">
        <property type="protein sequence ID" value="KER18898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177357.1">
        <property type="nucleotide sequence ID" value="XM_009179093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW41"/>
    <dbReference type="GeneID" id="20329929"/>
    <dbReference type="KEGG" id="ovi:T265_15764"/>
    <dbReference type="CTD" id="20329929"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9064" checksum="AFB78649EACC4607" modified="2014-10-01" version="1" fragment="single">MFSDLYSNVGNCVPLSLIAQSTGRATIAGIKWRQRVRKVPTAERLLVHKSPAAASMRNLRPRYGRAGTASTGACLFRNVAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX90</accession>
    <name>A0A074YX90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597266">
        <property type="protein sequence ID" value="KER19263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176991.1">
        <property type="nucleotide sequence ID" value="XM_009178727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX90"/>
    <dbReference type="GeneID" id="20329767"/>
    <dbReference type="KEGG" id="ovi:T265_15602"/>
    <dbReference type="CTD" id="20329767"/>
    <dbReference type="OrthoDB" id="424490at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="691" mass="77610" checksum="E5C3AAE99D0644BD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYK5</accession>
    <name>A0A074YYK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604843">
        <property type="protein sequence ID" value="KER18272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177981.1">
        <property type="nucleotide sequence ID" value="XM_009179717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYK5"/>
    <dbReference type="GeneID" id="20326492"/>
    <dbReference type="KEGG" id="ovi:T265_12324"/>
    <dbReference type="CTD" id="20326492"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6885" checksum="AE890FA3322C46F9" modified="2014-10-01" version="1">MEFKKSEVIAACITRGEIRQDLEDSNLVTYTIAYDEYHEDLVKKGQIGYLSSKTVLTTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZE3</accession>
    <name>A0A074YZE3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_15962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL599535">
        <property type="protein sequence ID" value="KER18582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177671.1">
        <property type="nucleotide sequence ID" value="XM_009179407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZE3"/>
    <dbReference type="STRING" id="6198.A0A074YZE3"/>
    <dbReference type="GeneID" id="20330127"/>
    <dbReference type="KEGG" id="ovi:T265_15962"/>
    <dbReference type="CTD" id="20330127"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER18582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="23952" checksum="92CA9810D757A43F" modified="2014-10-01" version="1" fragment="single">MENRMSPYQVNEKSRDLTGSVLHASPDVTTSEDELFSQSSVKDDPVLPSEASSGKTTQNLYTCKVCDKPFQFRSKLERHQAIHDNIKKHQCKFCDAKFNDPSAVRRHQKLQHSDEETMRSFRKHVCPLCGKRFLFATDIPNHLVVHTNEKDFVCEVCGATFTVLSTLMRHKRAFHEESGKGKLENNFEAMAKETGQEQDSEPTVDCSDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZJ2</accession>
    <name>A0A074YZJ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ALIX V-shaped domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599103">
        <property type="protein sequence ID" value="KER18627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177626.1">
        <property type="nucleotide sequence ID" value="XM_009179362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZJ2"/>
    <dbReference type="STRING" id="6198.A0A074YZJ2"/>
    <dbReference type="GeneID" id="20326379"/>
    <dbReference type="KEGG" id="ovi:T265_12211"/>
    <dbReference type="CTD" id="20326379"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13617" checksum="30011FEA9BDA5B02" modified="2014-10-01" version="1">MLAKRFEQDLPMFELLSKSNDEILAAIRGESAVSASSPTGNEAAREALARTCSQIESLKADRNSLTDQMNAMKLSEDFCKCFQLPPSYLPATVFDAFFISDYLLCLWFFMGNFDPLRWVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z293</accession>
    <name>A0A074Z293_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596993">
        <property type="protein sequence ID" value="KER21113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175140.1">
        <property type="nucleotide sequence ID" value="XM_009176876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z293"/>
    <dbReference type="GeneID" id="20324661"/>
    <dbReference type="KEGG" id="ovi:T265_10493"/>
    <dbReference type="CTD" id="20324661"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11538" checksum="DBCCA88C6073A61E" modified="2014-10-01" version="1">MIGVNESSGRFKKTRSREDGCPVFNPKLWQSAKVLAAHVGQLDMNQVAVHLFVERATDGVQRDEKITGVMNFFKAVCATTSLLINKFTHWTQACRYEVAIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2M8</accession>
    <name>A0A074Z2M8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597142">
        <property type="protein sequence ID" value="KER19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176486.1">
        <property type="nucleotide sequence ID" value="XM_009178222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2M8"/>
    <dbReference type="GeneID" id="20325710"/>
    <dbReference type="KEGG" id="ovi:T265_11542"/>
    <dbReference type="CTD" id="20325710"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10117" checksum="0396A7E2AB9AC928" modified="2014-10-01" version="1">MRITKPALVDEQLGKLGGLVSRWLSDDDLFPNPDSEENTTKSDVGSGSGEPISLFRFAIAQERICRVMRKAEPVHLLRFLPVRFLDDLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2S3</accession>
    <name>A0A074Z2S3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597134">
        <property type="protein sequence ID" value="KER19812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176441.1">
        <property type="nucleotide sequence ID" value="XM_009178177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2S3"/>
    <dbReference type="STRING" id="6198.A0A074Z2S3"/>
    <dbReference type="GeneID" id="20329616"/>
    <dbReference type="KEGG" id="ovi:T265_15451"/>
    <dbReference type="CTD" id="20329616"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="101"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="650" mass="71196" checksum="25518B316212E038" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Z7</accession>
    <name>A0A074Z3Z7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL614937">
        <property type="protein sequence ID" value="KER18045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178208.1">
        <property type="nucleotide sequence ID" value="XM_009179944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Z7"/>
    <dbReference type="STRING" id="6198.A0A074Z3Z7"/>
    <dbReference type="GeneID" id="20330500"/>
    <dbReference type="KEGG" id="ovi:T265_16335"/>
    <dbReference type="CTD" id="20330500"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10281" checksum="D16DEBA95FD092F8" modified="2014-10-01" version="1" fragment="single">MYLQRPSETPLMSFPMYESPKNYSTPASSSYRLGDTSHVTESEENIPVWLSTRDGYKAATLLNCLPNGRGRILILPEQEELEIDIECLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z453</accession>
    <name>A0A074Z453_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174381.1">
        <property type="nucleotide sequence ID" value="XM_009176117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z453"/>
    <dbReference type="GeneID" id="20324071"/>
    <dbReference type="KEGG" id="ovi:T265_09903"/>
    <dbReference type="CTD" id="20324071"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10007" checksum="B4BF8A7514EDCACA" modified="2014-10-01" version="1">MQSCGSSSRIPIASAIDSSLDRTSRGPFRGTHHIPGTSERTTTGTIQTTIDRRGDRNPTAGSTTLHPKENCATSELELAYETSGPTTCPTVTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z565</accession>
    <name>A0A074Z565_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596912">
        <property type="protein sequence ID" value="KER22198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174055.1">
        <property type="nucleotide sequence ID" value="XM_009175791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z565"/>
    <dbReference type="GeneID" id="20323819"/>
    <dbReference type="KEGG" id="ovi:T265_09651"/>
    <dbReference type="CTD" id="20323819"/>
    <dbReference type="OrthoDB" id="10508173at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9476" checksum="10D3837574BF7F73" modified="2014-10-01" version="1">MLLAVPETRREMRAEDESVCKQKNLARIELISSAYPMAVPGFEPRIPDMRGERVVTTPPTHVGRIWIFTSEQANVFTLERCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5U1</accession>
    <name>A0A074Z5U1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596895">
        <property type="protein sequence ID" value="KER22506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173759.1">
        <property type="nucleotide sequence ID" value="XM_009175495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5U1"/>
    <dbReference type="GeneID" id="20329005"/>
    <dbReference type="KEGG" id="ovi:T265_14839"/>
    <dbReference type="CTD" id="20329005"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="18768" checksum="8237FA47EF16FB3F" modified="2014-10-01" version="1" fragment="single">MTLSFFGAIRTPTNPPVMLHSDCKTMIMPDVSCVFDVVVIAAAVELPLTARAKVQNTACTPLSSSLSTCGAGTCPREPGEPRERFEMPNSVCQKTIDTALLLTASSAGPENYMSGRFAHSSATDINILLPVRHCLQLCPIYTYSGASVLTERQTNRGSNSELFGWRASVPPTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z718</accession>
    <name>A0A074Z718_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596875">
        <property type="protein sequence ID" value="KER22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173375.1">
        <property type="nucleotide sequence ID" value="XM_009175111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z718"/>
    <dbReference type="GeneID" id="20323299"/>
    <dbReference type="KEGG" id="ovi:T265_09120"/>
    <dbReference type="CTD" id="20323299"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13347" checksum="889E0ECF7698F99D" modified="2014-10-01" version="1">MSAEALANVPMLKSYDLRMRCYRFPISDEQHNAPTPGSTQQESITFGFMAIRSSKSAYLNAQERLSNVVKTKHILMVQACTPRELTINVYLGSIFIGILQTRISRLRERKRSLEPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7A4</accession>
    <name>A0A074Z7A4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597339">
        <property type="protein sequence ID" value="KER19090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177162.1">
        <property type="nucleotide sequence ID" value="XM_009178898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7A4"/>
    <dbReference type="GeneID" id="20329830"/>
    <dbReference type="KEGG" id="ovi:T265_15665"/>
    <dbReference type="CTD" id="20329830"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8577" checksum="920B86F3A009D044" modified="2014-10-01" version="1" fragment="single">MSLHPKPPCIPRALPLSWMIKTLEARVTMPMSRARPFTKAQRNPPSSEKLGITSFADLVTKYQKIISCTEIYICGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L1</accession>
    <name>A0A074Z7L1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173099.1">
        <property type="nucleotide sequence ID" value="XM_009174835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L1"/>
    <dbReference type="STRING" id="6198.A0A074Z7L1"/>
    <dbReference type="GeneID" id="20328863"/>
    <dbReference type="KEGG" id="ovi:T265_14697"/>
    <dbReference type="CTD" id="20328863"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="17116" checksum="5C81980B4F1C2B2D" modified="2014-10-01" version="1" fragment="single">CCVHAPASNAQLPTLPLWIIGEQTCGSYNHCTISTRLLKLDNDMMPILQKESAACCVHAPASNAQLPTLPLWIIGEQTCGSYNHCTISTRLLKLTMMMMTILQKESAAVSHSLQYQAFLVIPFPTIDVTHLGVPSRKMAVTSAAELAGNGFHTSLPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8C6</accession>
    <name>A0A074Z8C6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596938">
        <property type="protein sequence ID" value="KER21817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174425.1">
        <property type="nucleotide sequence ID" value="XM_009176161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8C6"/>
    <dbReference type="STRING" id="6198.A0A074Z8C6"/>
    <dbReference type="GeneID" id="20324104"/>
    <dbReference type="KEGG" id="ovi:T265_09936"/>
    <dbReference type="CTD" id="20324104"/>
    <dbReference type="OrthoDB" id="10035275at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703971" description="MATH domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="93308" checksum="AE3F5DBF387EEF4D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8D3</accession>
    <name>A0A074Z8D3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172768.1">
        <property type="nucleotide sequence ID" value="XM_009174504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8D3"/>
    <dbReference type="GeneID" id="20322817"/>
    <dbReference type="KEGG" id="ovi:T265_08638"/>
    <dbReference type="CTD" id="20322817"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3 4">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="56851" checksum="2654ACAA5ECCBFF5" modified="2014-10-01" version="1">MIGNRKLFDRSCFEFSRVDQMTRMITTPGILDHVWIILDALLLRVAFTSSLFDNASAQKINLRDAFCNDLLPPRLSFEHYDLTLGTLGKKYHTLESLFSSQVMNALKPIMRLECLDGNVSVACIRTVRTHLYGAFEKLLSLPGENTTFGRNHSLLFINFISKNGDWLESTRTLFAMSCLTICKVLYEQQDQRFNWFCPNPCQLQTSCALEHCTPRGIFAHHFRCRCPNGQVWNEEMSTCLPVKEVARITNTWTPTECEDKCYKTGTLSCYPSAIDDELSICLCKPGFTGPSCSQEQNPCTEKIEHSALPSGGMVLAGDDACNVHNGNTCRGQILADGTVHYMCICDGVHWQKNHTLGYDNCLWRKSACDSIICTYGRCVSSASGKLWVGIWSQWSPWDKCRPQCGDLRYSVRSRDCQSMKPEVEKKFDCVGASIEYASCAPHPCARSEGLYMNSYFAIRQNAMAAGISTAAISCAIVSVFWLAFLSTMLSRTVWLLVRSIGTERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z971</accession>
    <name>A0A074Z971_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597140">
        <property type="protein sequence ID" value="KER19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176474.1">
        <property type="nucleotide sequence ID" value="XM_009178210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z971"/>
    <dbReference type="STRING" id="6198.A0A074Z971"/>
    <dbReference type="GeneID" id="20325699"/>
    <dbReference type="KEGG" id="ovi:T265_11531"/>
    <dbReference type="CTD" id="20325699"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="31627" checksum="1ED12108F8307BE2" modified="2014-10-01" version="1">MTSSPTPFFHLCLSGERQPLNDKNKTDPGNLDKSLDPVYQSIRRYIDSYNRAYVITFNNPRNQKINELRHYLKDGQIIFGKNKVTILALGKRSGKALRPHLDELSKFIRGQCALLLTNLSVQELREKFDALRSSEFARPGVRAPQTVTLAAGPCHKFAHTLEPYLRELGLPVKLVRGIVTLEEDYIVCRRDQELTPEQCRVLKLFELQLSEFRVAIIAFWSEEEGVLEVSDSDSRQMITSLAPAVRVTCQKLDDGQYYFIPEVVPDEPEDALMTDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9G8</accession>
    <name>A0A074Z9G8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596837">
        <property type="protein sequence ID" value="KER23753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172506.1">
        <property type="nucleotide sequence ID" value="XM_009174242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9G8"/>
    <dbReference type="GeneID" id="20322620"/>
    <dbReference type="KEGG" id="ovi:T265_08441"/>
    <dbReference type="CTD" id="20322620"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="17366" checksum="01993895529DA83A" modified="2014-10-01" version="1">MPETSREAQRTMRLTRNPAESLKFDVSRKPNVLHQAASDFSPYDIRGFAIHISFSFQVEHKIDGKSGTAPTCLQPNTAGLRGPPEPDHTAMSRWKFIFPPTTHLPRKRRNEAKETLVPHNSNVNRLQISVFVEISPIWVQVEHKVDGKSGTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9J1</accession>
    <name>A0A074Z9J1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597119">
        <property type="protein sequence ID" value="KER19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176344.1">
        <property type="nucleotide sequence ID" value="XM_009178080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9J1"/>
    <dbReference type="GeneID" id="20325594"/>
    <dbReference type="KEGG" id="ovi:T265_11426"/>
    <dbReference type="CTD" id="20325594"/>
    <dbReference type="OrthoDB" id="6252736at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="22181" checksum="18795D655A3D0D23" modified="2014-10-01" version="1">MIYLNANCTVFEKYTYLQLNVLDQAASCFSRYDIREIAIYIFCNALIVRLLKVRRQPTTAFPSLGAHQTTECAALGRLMFQLIRYWRYRNTYTTHKGGFCGAKDYYETCSQTTQHLLDRTCYSERYINLFDCSFLVLKKASAAELFIRKYQLESYRLFYRRKKLSYTSCLQKLNISLLLERVFLNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBK7</accession>
    <name>A0A074ZBK7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597039">
        <property type="protein sequence ID" value="KER20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175651.1">
        <property type="nucleotide sequence ID" value="XM_009177387.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZBK7"/>
    <dbReference type="GeneID" id="20325057"/>
    <dbReference type="KEGG" id="ovi:T265_10889"/>
    <dbReference type="CTD" id="20325057"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="919"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="919"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1265"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1387"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1500"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1768"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1396"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1430"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1789"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1852" mass="211925" checksum="CD7C8299B900D5F0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBM6</accession>
    <name>A0A074ZBM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597037">
        <property type="protein sequence ID" value="KER20630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175624.1">
        <property type="nucleotide sequence ID" value="XM_009177360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBM6"/>
    <dbReference type="STRING" id="6198.A0A074ZBM6"/>
    <dbReference type="GeneID" id="20325035"/>
    <dbReference type="KEGG" id="ovi:T265_10867"/>
    <dbReference type="CTD" id="20325035"/>
    <dbReference type="OrthoDB" id="6276451at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26387" checksum="97439B0E0F95D1A5" modified="2014-10-01" version="1">MFDDFIGFNQQPRKLRLPPVPTTSTDSDPILASILHLQAKFDVLTNRIQRLKINNKINKINKTNKHPPRSQSRSLFSARPFWCCYHQSYGPKARTCQPPCSFQHPFKHPGQSVTARTVCIPPRISRLFHITDRSSGLRFLADTGAEVSLLPHKNPLSDSASFSLQAANGTRIATYSKRSLTLDLGLRRAFKWIYPLADVQAPIIGADFLTHYNLPVDVQNKRLLDMLTPISVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCI0</accession>
    <name>A0A074ZCI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172958.1">
        <property type="nucleotide sequence ID" value="XM_009174694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCI0"/>
    <dbReference type="STRING" id="6198.A0A074ZCI0"/>
    <dbReference type="GeneID" id="20322973"/>
    <dbReference type="KEGG" id="ovi:T265_08794"/>
    <dbReference type="CTD" id="20322973"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="4">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="5">
        <location>
            <begin position="456"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="932" mass="105251" checksum="1DD32C39698B5CB5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCN3</accession>
    <name>A0A074ZCN3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_08704</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172848.1">
        <property type="nucleotide sequence ID" value="XM_009174584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCN3"/>
    <dbReference type="STRING" id="6198.A0A074ZCN3"/>
    <dbReference type="GeneID" id="20322883"/>
    <dbReference type="KEGG" id="ovi:T265_08704"/>
    <dbReference type="CTD" id="20322883"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705047" description="Endoplasmic reticulum chaperone BIP" evidence="16">
        <location>
            <begin position="20"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="648" mass="71442" checksum="ADC5117FAC35685E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDH4</accession>
    <name>A0A074ZDH4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596779">
        <property type="protein sequence ID" value="KER25351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170870.1">
        <property type="nucleotide sequence ID" value="XM_009172606.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZDH4"/>
    <dbReference type="GeneID" id="20321334"/>
    <dbReference type="KEGG" id="ovi:T265_07155"/>
    <dbReference type="CTD" id="20321334"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="788"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1561" mass="170386" checksum="54FEC7A1BF0AC9D6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDY0</accession>
    <name>A0A074ZDY0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170748.1">
        <property type="nucleotide sequence ID" value="XM_009172484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDY0"/>
    <dbReference type="GeneID" id="20321234"/>
    <dbReference type="KEGG" id="ovi:T265_07055"/>
    <dbReference type="CTD" id="20321234"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12954" checksum="14F7A8C7033F8BF1" modified="2014-10-01" version="1">MDGELCQVDSKSLSDMRGKKNTEQAQQANEAANQIGRKKAAPERDHFSDWTPCDWSVEWLARLREKTGNDEDHLWNIQLQQTGTSSTVEPSPALEQDSVLERRTLWHLSSPAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEG0</accession>
    <name>A0A074ZEG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170707.1">
        <property type="nucleotide sequence ID" value="XM_009172443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEG0"/>
    <dbReference type="GeneID" id="20321201"/>
    <dbReference type="KEGG" id="ovi:T265_07022"/>
    <dbReference type="CTD" id="20321201"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="24239" checksum="4C0474BF4CE32AF6" modified="2014-10-01" version="1">MNRFGGEMRSVTKLRRMTGTTFADQECESFAVVYQRFQGTQSIFGNTRHVAVEDDKKRPWVRKDSDILENMQALVCATQYMSFRMTTQALKRTNPPPPYSVIALQIDGFYSEEKLLQKGNHTPRVVVGPSEIKRGPRDPHCAWLGTLNIWLPKDVSGVFVVSFYRDCLSECLEIVVKKVGGPGREHSRLTRPCTLSRSVDSGTLNAVAAPRKDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEM3</accession>
    <name>A0A074ZEM3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170548.1">
        <property type="nucleotide sequence ID" value="XM_009172284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEM3"/>
    <dbReference type="GeneID" id="20321075"/>
    <dbReference type="KEGG" id="ovi:T265_06896"/>
    <dbReference type="CTD" id="20321075"/>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="582" mass="64936" checksum="3767A6FC5FCF904A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF06</accession>
    <name>A0A074ZF06_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GPI alpha-1,4-mannosyltransferase I, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GPI mannosyltransferase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Phosphatidylinositol-glycan biosynthesis class M protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_08096</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596819">
        <property type="protein sequence ID" value="KER24207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172059.1">
        <property type="nucleotide sequence ID" value="XM_009173795.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZF06"/>
    <dbReference type="GeneID" id="20322275"/>
    <dbReference type="KEGG" id="ovi:T265_08096"/>
    <dbReference type="CTD" id="20322275"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="866"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1076"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1100"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1124"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1160"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1230"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="19">
        <location>
            <begin position="418"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="20">
        <location>
            <begin position="493"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="589"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KER24207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1283" mass="145726" checksum="A66D79DD5926132B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF89</accession>
    <name>A0A074ZF89_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596933">
        <property type="protein sequence ID" value="KER21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174353.1">
        <property type="nucleotide sequence ID" value="XM_009176089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF89"/>
    <dbReference type="STRING" id="6198.A0A074ZF89"/>
    <dbReference type="GeneID" id="20324050"/>
    <dbReference type="KEGG" id="ovi:T265_09882"/>
    <dbReference type="CTD" id="20324050"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="481" mass="55180" checksum="36079620954D3074" modified="2014-10-01" version="1">MDTPTYSLAKKLWRKIKYLINKSQHSIKNAQQFLDKLKNVTIEEDETMVSFDVSSLFTSVDLHSAKTTVAELLDSHGPPSGPLRKEDICELLSLCLTTYFEFNGEYYEQLKGAPMGSPISGFIAEIAMQKLERTVLPDINPKLWVRYVDDTFVIIKKRELQRAIQLINSVSDDIKFTMEEENNNKLAVLDVLVTRLPNGQMQTEVYRKATHTDQILSYHSNHPNCHKESCIRTLFKRIETHCNTVESKVKEEKRLYRIFQRNGYPRNFVWRSLRKCNSTNATTRNTSKTITLPYIKNISEMTARILQQHAIKVAHRPTDTLRRVLSKPKGTLNAMEKTNVIYKIQCKNCEKHINAILRDSLVGFIAYGVEMLLEHFLAGLNTDVEHYCPTADDDDDDDDDDDDDDEDDDDDDDDDDDDDDDENEDDDGDDGNDNVCDVYNSSNPEGVNLGYQTLALALKATSFPYKSDPLARLEYRANRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF99</accession>
    <name>A0A074ZF99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171938.1">
        <property type="nucleotide sequence ID" value="XM_009173674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF99"/>
    <dbReference type="GeneID" id="20322172"/>
    <dbReference type="KEGG" id="ovi:T265_07993"/>
    <dbReference type="CTD" id="20322172"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="10041" checksum="F84575265C938595" modified="2014-10-01" version="1">MGPSEIRNGPLAHQDMVISVFVLAHVSQPIWLRRIAETTEQLAKPNTKKRDSDQRFVAVSTDKKFAGVIREEHLPGWRQESTFESQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFC4</accession>
    <name>A0A074ZFC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170352.1">
        <property type="nucleotide sequence ID" value="XM_009172088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFC4"/>
    <dbReference type="STRING" id="6198.A0A074ZFC4"/>
    <dbReference type="GeneID" id="20320922"/>
    <dbReference type="KEGG" id="ovi:T265_06743"/>
    <dbReference type="CTD" id="20320922"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="452" mass="49006" checksum="6FCE1E16B470C173" modified="2014-10-01" version="1">MLRTLLLLFYLYLLEGIPYGLQSRFLPLLLRSSGLSLTALGFYKLLYVPWLLKSFYAPLVDLCLTKRYWLFGSLVGLLTVTLTLALGENLIPRETSSQTTGSASVVPLALCLFLYNLFAATQDIAVDGVALQLLSSDQLSVGNTIQVVGYKFGAIVGGGFLTAATSLFSASQLLGIIACVYVIGAMLCITSTTLRDVEAAWSENQTTICVQENGQLDDGQVGRMKDDGCMGSVRQASYVATLSEAVINSVGSRHLIALLLVYKLGEQGAMNMLPLMLFDRGASVAKIGLWSGMVGQLSSILGSTFAHKLQAPGRSSADVLERLMLFRAILQLPLLLIAVEHVGVGFHEHSFAVAMLFMNLTLFVSGAITTVMFTIMMQCTRAESPVQTQATHYTVLSTAELLGKLIFGVVAAPFTDYLGYGTANLTFVLLSVVPVYFVRARRDCFLFERKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFZ8</accession>
    <name>A0A074ZFZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170084.1">
        <property type="nucleotide sequence ID" value="XM_009171820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFZ8"/>
    <dbReference type="GeneID" id="20320716"/>
    <dbReference type="KEGG" id="ovi:T265_06537"/>
    <dbReference type="CTD" id="20320716"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14767" checksum="6EBA86A074EBA6C6" modified="2014-10-01" version="1">MNKLTLSGKTYHSYSYLSFPILEFNSTLTGRSHTHFTISKCPHEYAPAYDMDRLLRNVASKWHITGPQDLRVPRTRFMTTNASETSLVSYGVNGIPNWFFYVLGRDVEFISKRWDNALFTWSHSAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGS0</accession>
    <name>A0A074ZGS0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169826.1">
        <property type="nucleotide sequence ID" value="XM_009171562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGS0"/>
    <dbReference type="GeneID" id="20320511"/>
    <dbReference type="KEGG" id="ovi:T265_06329"/>
    <dbReference type="CTD" id="20320511"/>
    <dbReference type="OrthoDB" id="10583717at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14978" checksum="33DC52D05A444A89" modified="2014-10-01" version="1">MPLGRRLSIMRHNRHEETGPYNGVAVCVPRRPIELYWGVSARYSQSLSYQAGTLAFAHRRWSATQATTLPNPLGCLSKDTVAPDNLSSMREDDSGKKCYELETRLDESYESTWGQPKLYLTLNMQKLALLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGT6</accession>
    <name>A0A074ZGT6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171370.1">
        <property type="nucleotide sequence ID" value="XM_009173106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGT6"/>
    <dbReference type="GeneID" id="20321735"/>
    <dbReference type="KEGG" id="ovi:T265_07556"/>
    <dbReference type="CTD" id="20321735"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="22730" checksum="AE822265AA607CCF" modified="2014-10-01" version="1">MSEESKQCVGFNTNALFSPFDARFAGCQRSVQRWTGANLVTLTVIMISIILAVNMIVNMVIVTIIVNLIIIVIVVSYNTLRGYKRHLSAKKNANEPYGSTLSRTLSENAVQLITGGMFEMVNHPAGLKSQSQEGNETPFLVQTAKNKRNKVFVEGFDTPVDRQAAMRRFKTARMAPGCDPTVFFASLQHPLDRALLGLDSVAPPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHK0</accession>
    <name>A0A074ZHK0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596883">
        <property type="protein sequence ID" value="KER22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173524.1">
        <property type="nucleotide sequence ID" value="XM_009175260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHK0"/>
    <dbReference type="GeneID" id="20323414"/>
    <dbReference type="KEGG" id="ovi:T265_09235"/>
    <dbReference type="CTD" id="20323414"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6565" checksum="23B480ECB691721C" modified="2014-10-01" version="1">MILEGQVPGQPQATVMPSLRWSDNLEREAMNEAEKCMIPRETVPGEIQIYSRDENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHT4</accession>
    <name>A0A074ZHT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596877">
        <property type="protein sequence ID" value="KER22835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173410.1">
        <property type="nucleotide sequence ID" value="XM_009175146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHT4"/>
    <dbReference type="STRING" id="6198.A0A074ZHT4"/>
    <dbReference type="GeneID" id="20323323"/>
    <dbReference type="KEGG" id="ovi:T265_09144"/>
    <dbReference type="CTD" id="20323323"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19574" checksum="65320F71E59788EE" modified="2014-10-01" version="1">MGKAAFPYGGRGLLVRFLSTTLKMAREPMNFSWVSDSVAGFAFPYDKEEWEYLSNVAKLSHVITMCHESPHYASEYQNIKHHHLPVDDLSPANLSIIQKAMKIIQDAEAKEQKVGVHCQLGRGRAGTILACYLARKNGWDADTAIRELRRLRPKSIDVDQEQAVLKYVQSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI84</accession>
    <name>A0A074ZI84_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual serine/threonine and tyrosine protein kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dusty protein kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Receptor-interacting serine/threonine-protein kinase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_05863</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169248.1">
        <property type="nucleotide sequence ID" value="XM_009170984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI84"/>
    <dbReference type="STRING" id="6198.A0A074ZI84"/>
    <dbReference type="GeneID" id="20320045"/>
    <dbReference type="KEGG" id="ovi:T265_05863"/>
    <dbReference type="CTD" id="20320045"/>
    <dbReference type="OrthoDB" id="122279at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051302">
        <property type="entry name" value="Dual_SerThr-Tyr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392">
        <property type="entry name" value="DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46392:SF1">
        <property type="entry name" value="DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="743"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER27033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="977" mass="109392" checksum="372F88FDB97CFAB1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJV1</accession>
    <name>A0A074ZJV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168592.1">
        <property type="nucleotide sequence ID" value="XM_009170328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJV1"/>
    <dbReference type="STRING" id="6198.A0A074ZJV1"/>
    <dbReference type="GeneID" id="20319519"/>
    <dbReference type="KEGG" id="ovi:T265_05337"/>
    <dbReference type="CTD" id="20319519"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11712" checksum="2356F347F49C7458" modified="2014-10-01" version="1">MYIFAQYDGHFAPDEIFNSLYLSPMDIEELSPFFDNLFQNWSRGSRWPRWLEQEFTDRKVRGSNPTSSSRLTLSRLGQSGSIPGLVLPSGSMAARHRKGVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKR6</accession>
    <name>A0A074ZKR6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Radial spoke protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168602.1">
        <property type="nucleotide sequence ID" value="XM_009170338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKR6"/>
    <dbReference type="STRING" id="6198.A0A074ZKR6"/>
    <dbReference type="GeneID" id="20319529"/>
    <dbReference type="KEGG" id="ovi:T265_05347"/>
    <dbReference type="CTD" id="20319529"/>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="52587" checksum="100E7AF913491E8C" modified="2014-10-01" version="1">MTTLVQRNTEGTYSFASQPKAVAGRSKYRDGELKFPGVERESYGNIMYDKRVIRGNTYALRVASTHWGSTKNVGSTASSRKFNKLRRTQEDYKVHEFLISLSSEPFAVLSRLSQLPPAELSGRLHVPVQTEQYLEALTDIIDEADVECQTDAFLDRPPTPQFVPAKTGADVETQIYEGDVSICFECLITFVFLPLIFYPSPLKPPNVNVCTKLFDFDLEVREILEVLLGKTLEQALLEVAEEEELADLRAQQSAFEEIRSAEIAEVQRLMEQDKRLRTEKEERRQQYVAAVAQQKELAAKVAARAFAKAYLSDLQPRVFDKLKEQGYFYDPVEHDIENGFIPWLMEEVEEELELDNRARALLDLMIREVVTERYNEYHQLELMDEQRAKDLLIKSQQADLQKPEEPQDSLSVVQSDVQQPKVEETEEQPVEREMTSLDEVEEVEEKEEPTEDTEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLI7</accession>
    <name>A0A074ZLI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_13959</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169624.1">
        <property type="nucleotide sequence ID" value="XM_009171360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLI7"/>
    <dbReference type="STRING" id="6198.A0A074ZLI7"/>
    <dbReference type="GeneID" id="20328126"/>
    <dbReference type="KEGG" id="ovi:T265_13959"/>
    <dbReference type="CTD" id="20328126"/>
    <dbReference type="OrthoDB" id="21182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="12">
        <location>
            <begin position="561"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="697"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="890" mass="99001" checksum="74F19D321D050801" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLM0</accession>
    <name>A0A074ZLM0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_05102</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168283.1">
        <property type="nucleotide sequence ID" value="XM_009170019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLM0"/>
    <dbReference type="STRING" id="6198.A0A074ZLM0"/>
    <dbReference type="GeneID" id="20319284"/>
    <dbReference type="KEGG" id="ovi:T265_05102"/>
    <dbReference type="CTD" id="20319284"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="295"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="247"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER27981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="39582" checksum="12BD13E9F9F1E2A7" modified="2014-10-01" version="1">MCEFDVVVVGSVNTDLSIFVERHPNAGETVMGRSFAMGFGGKGSNQAVAARLLGSNVALIAKIGSDTFGQNFIVRLDALGIDRRGVTETVEASTGTAFITVEHTRGENRIIVVPGANMLLSAEEINVAQQLGLLNGRVVVCQFEVCATASLCAMELAQQNGAVTILNPAPPTVPIQGANHLEVLKKLLAVSDYCCPNETEALQLAHCYGHIAPEFDPKKSNMDPLLSTFRQCLLWLSNQGVKHPIITMGSKGTVALLETTKIPDQLPPDVSIVHTKQLRTGILANFVILHLSAPTISDAVDTTGAGDSFVGALAHFISRHPNLGPVEHIRRAIWVASQSIRKAGTQSSYPGRNELPSSLFGTDEFIWPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM49</accession>
    <name>A0A074ZM49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 222</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169389.1">
        <property type="nucleotide sequence ID" value="XM_009171125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM49"/>
    <dbReference type="GeneID" id="20320155"/>
    <dbReference type="KEGG" id="ovi:T265_05973"/>
    <dbReference type="CTD" id="20320155"/>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33308" checksum="E0CF1B2D286145C2" modified="2014-10-01" version="1">MEKITERLGAGGATHPLGWGSRDPHCLRLETLQEMAVNRCQWRSGCLDNLTVSQPSCVLLVARQLSIERALQPNHYYTIITSTYIIDSQNDKLEYSDTARMGEMSPTHEDRIPVVEFQGPTRSRVDQLPVSPHLHRFPHSLVWTPIPLLTWLFPIIGHMGITNTAGIIYDFAAPYTICEDNMAFGWPTMYCQLDLSHVESREMWDKAVFGANEVYKLRVHNLFCDNCHSHVARALNGMRYRGRSNWNMFSVTLLFFSRARYVNKSVLPSVGTRIHITNNRQSNDQSQRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMA1</accession>
    <name>A0A074ZMA1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Kynureninase</fullName>
            <ecNumber evidence="1 2">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="1 2"/>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168059.1">
        <property type="nucleotide sequence ID" value="XM_009169795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMA1"/>
    <dbReference type="STRING" id="6198.A0A074ZMA1"/>
    <dbReference type="GeneID" id="20319109"/>
    <dbReference type="KEGG" id="ovi:T265_04927"/>
    <dbReference type="CTD" id="20319109"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="474" mass="53262" checksum="176FFF822737281B" modified="2014-10-01" version="1">MDYRQLADKQNLRFDCIEFAQWLDSNDPLGWLREEFDHPTFECLEKMTTISITPKEKRSGNTVTYLCGNSLGLPPKKLASVLQDTIQNWSGLGVHAYMNGPLPASLCDITLTEDIAKYIVGAETDEVAVTANLSVNMHILLATFYRPEGTKSCILIEKGAFPSDYYVIESQIAWHGLDPKDNIIMLEPRPGEWCLRTEDIVQTIKDNSHRIALIWLPGVQFITGQSFDMERITEAGHKFAQCCVGWDLAHSVGNVVLELHKWNVDVAVWCSYKYLNGSPGALGGLFVHRRHHHQPGINGSRISRPGIIPTGPQLTGWWSHRIETRFQMTGNMELATGAQAYRISNPPLLLAAALKTSVDLFKQCGGVSELRKKSVLLTGYLEYLIEHGQFSLPNNLFEIVTPKEKEARGAQLTLFVQKNLQQLYEGLASEGIIVDTRPPNCIRIAPVPLYNRFIDVFNFVRLLHCLVSKLPMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN69</accession>
    <name>A0A074ZN69_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169120.1">
        <property type="nucleotide sequence ID" value="XM_009170856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN69"/>
    <dbReference type="STRING" id="6198.A0A074ZN69"/>
    <dbReference type="GeneID" id="20319958"/>
    <dbReference type="KEGG" id="ovi:T265_05776"/>
    <dbReference type="CTD" id="20319958"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="181" mass="20839" checksum="21ED6D6800710427" modified="2014-10-01" version="1">MRDYVGRIPLIIAQLDAEVRIVTSRLEVCSYSGFKVYPGHGKRAIRLDGRGFYFINSKCERSHYLKRNPREICWTVLYRRKNKKGLSEEQSKKRTKRSTKTTRAIAGASLAEIMAKRNQKPEVRKAMRDQAIRAAKDKQRQKELEKKAKKMEAKKKPAAAQPKQKPTKITQKAAPRVGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNQ5</accession>
    <name>A0A074ZNQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171270.1">
        <property type="nucleotide sequence ID" value="XM_009173006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNQ5"/>
    <dbReference type="GeneID" id="20321652"/>
    <dbReference type="KEGG" id="ovi:T265_07473"/>
    <dbReference type="CTD" id="20321652"/>
    <dbReference type="OrthoDB" id="6311203at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="219" mass="25125" checksum="F107760A031B42D5" modified="2014-10-01" version="1">MGLKEIRRLRLPYEPQKEKWLLICSPSLAIDLQTFRHHSRRHLQCAVGWRSRPRRNTDREWANQNPGYSAKAAHYRLYKRGHKERNYPTNSALKMSPRMVTKRLQINCQARRTDQQPPNQLPTNTTKLPIFQNITNFKGYLTGFIPCMPLLFSGDDDDDVADDDFDDDDDDDDDDDDDGDCGDGDDHDTSKYAIECAAPGQLIFQVKHMVAGNSVTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNX6</accession>
    <name>A0A074ZNX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168738.1">
        <property type="nucleotide sequence ID" value="XM_009170474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNX6"/>
    <dbReference type="GeneID" id="20319645"/>
    <dbReference type="KEGG" id="ovi:T265_05463"/>
    <dbReference type="CTD" id="20319645"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7432" checksum="CE964E1311541793" modified="2014-10-01" version="1">MVPFKGGISAALNPDHHVKVAALGREKQKYGAGEYALAIISALHAIGCYVDFLVHQPMIIYYRGICFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS50</accession>
    <name>A0A074ZS50_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170086.1">
        <property type="nucleotide sequence ID" value="XM_009171822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS50"/>
    <dbReference type="GeneID" id="20328217"/>
    <dbReference type="KEGG" id="ovi:T265_14051"/>
    <dbReference type="CTD" id="20328217"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="137" mass="15381" checksum="B6819B678199CEDA" modified="2014-10-01" version="1" fragment="single">RTGSTHLKHLNRSVTKRTPTSRKPSEPRCRATSCKLGSTLTNGKEFSTKLSEILMAGSPPLHVYEHHSYPGSDKRMAYVLLILNIYTMHLIIFQSPAELFGLAPGQNPDQGSRRFFSRITFKIVTNECSFSTDFSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSI1</accession>
    <name>A0A074ZSI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AGC-kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166194.1">
        <property type="nucleotide sequence ID" value="XM_009167930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSI1"/>
    <dbReference type="STRING" id="6198.A0A074ZSI1"/>
    <dbReference type="GeneID" id="20317633"/>
    <dbReference type="KEGG" id="ovi:T265_03446"/>
    <dbReference type="CTD" id="20317633"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9410" checksum="98C845C38030AE86" modified="2014-10-01" version="1">MNHSFFRPIDWVALEQKQVAPPYRPSYTDDYDLTHFDPTFTDEPVVFTPDNPEKIAKIDQTEFEGFEYVNPLLMSLEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSR6</accession>
    <name>A0A074ZSR6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169834.1">
        <property type="nucleotide sequence ID" value="XM_009171570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSR6"/>
    <dbReference type="GeneID" id="20320519"/>
    <dbReference type="KEGG" id="ovi:T265_06337"/>
    <dbReference type="CTD" id="20320519"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10951" checksum="E8206E6384CB4465" modified="2014-10-01" version="1">MSEQANVFTLERCDWCARLIERQPSVTEDAQPLLASNNIQEQKELVAASLSRAHSTRLTGLFCLTCLTTRNALKGGKHNKLFVFPDFLTCEIIRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSY3</accession>
    <name>A0A074ZSY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazolonepropionase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166074.1">
        <property type="nucleotide sequence ID" value="XM_009167810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSY3"/>
    <dbReference type="STRING" id="6198.A0A074ZSY3"/>
    <dbReference type="MEROPS" id="M38.980"/>
    <dbReference type="GeneID" id="20317536"/>
    <dbReference type="KEGG" id="ovi:T265_03349"/>
    <dbReference type="CTD" id="20317536"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26492" checksum="49A116DDB99D8CA1" modified="2014-10-01" version="1">MEIHESGGGINYTVSKTSAADEATLYNLLRQRLLGMIRKGTTTVECKTGYGLHWSVEEKLLRVLNRAKMELPMDISITFLSAHSVPKDSNASEFTEHIVSEQIPKLKNLIQQNISVDNIDVFCEKGVYDIEQSAKILRAGKSIGLNLNFHADELSDTGGAELAGRLGARAASHLEEASPAGVAAMAASGTAAVLLPTTAHLLRLRPPSARAIIQAGVPVALGTDFNPNAYCLSMASYSGYMVVQSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT56</accession>
    <name>A0A074ZT56_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ndr family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER29017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167284.1">
        <property type="nucleotide sequence ID" value="XM_009169020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT56"/>
    <dbReference type="GeneID" id="20327638"/>
    <dbReference type="KEGG" id="ovi:T265_13471"/>
    <dbReference type="CTD" id="20327638"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46391" checksum="DFD0287AF5FAC067" modified="2014-10-01" version="1">MEVPLVEFQGATNLHHRGPNAPLFSGSTSCGDEFSGGMPLHRTTPQLEEHEILTSTGVPQRVYVQRGHGKLALLTYHDIGTNHTSFLGFFNHPDMRVITKHFVVYHVCAPGHHENAPNVSLDDAAASNHSQSLLVDKEGGPEKAASTVSTRASHPTLPMGRAASSEVGLQYPNLDQLAEMVTSILVHFGIDYFVGFGMGAGSNVLSRYALHHPDNVLALFLLNPTATTHTYYQKYRCLWWDIPYLKQGVLTDYLLEQLDAHWFGYGLAENDDILHFYHQLARSLNPLNLAGYIRAFIDRTEINLIRPIGPAMPGEPEAPASEPTVIKTDVCLVTGHRAVDLCRILEEMNGQMDPKKTQFLTIPDCTGMVMEEDPDKLAVDFLHFLRSIGLWMAVDSSASACLAYLGVFGRRSSQTTGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUB1</accession>
    <name>A0A074ZUB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597951">
        <property type="protein sequence ID" value="KER18789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177465.1">
        <property type="nucleotide sequence ID" value="XM_009179201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUB1"/>
    <dbReference type="GeneID" id="20329991"/>
    <dbReference type="KEGG" id="ovi:T265_15826"/>
    <dbReference type="CTD" id="20329991"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9904" checksum="6363263458CE3E3A" modified="2014-10-01" version="1" fragment="single">MQEAVVTTTESQTNLKEDELTMRPLRWGLLVGFGPRDCCEKLLYQDHIDVPFTDKHGSAKIMQGIGATGMKQNEWLLKAIRTDHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUH3</accession>
    <name>A0A074ZUH3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165103.1">
        <property type="nucleotide sequence ID" value="XM_009166839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUH3"/>
    <dbReference type="GeneID" id="20316748"/>
    <dbReference type="KEGG" id="ovi:T265_02560"/>
    <dbReference type="CTD" id="20316748"/>
    <dbReference type="OrthoDB" id="10611527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33413" checksum="1FCD6617D2873469" modified="2014-10-01" version="1">MNFHAYRSRKTRGAVETGKRSVALNYGECKTDLSFQQNLALYSISRGSQVFSYGCRLAPPLTRKRGHTQNSDLSRLVCLGVLDHFNGAWVFDLLVYDALTDDSPWKSLLRVPIHENDQEIQILESQYHCKYNNIHIQHTSTDSPPRYNYQPEDKAQFTSPQNRYRHNQADIDGEQPQKSQCPIKVRKSYKNSSVKQGGFSSSGQGESVWGLAVTWGWKREHTVDKLSSTPPPKTPADFPPSSYGHSWLKYFTYPKFRVDLHQYAKRELLTRQLPVVSLYAMSSKTHLPPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUH7</accession>
    <name>A0A074ZUH7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597730">
        <property type="protein sequence ID" value="KER18854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177401.1">
        <property type="nucleotide sequence ID" value="XM_009179137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUH7"/>
    <dbReference type="GeneID" id="20326296"/>
    <dbReference type="KEGG" id="ovi:T265_12128"/>
    <dbReference type="CTD" id="20326296"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7658" checksum="7402A28011C69323" modified="2014-10-01" version="1">MEHFQEGPKATESADTVSSTTGSTLKPAFNVKLPEESGFLLDDEDDDLILQWFDARNLHVTLQAGPSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUP7</accession>
    <name>A0A074ZUP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169155.1">
        <property type="nucleotide sequence ID" value="XM_009170891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUP7"/>
    <dbReference type="STRING" id="6198.A0A074ZUP7"/>
    <dbReference type="GeneID" id="20319979"/>
    <dbReference type="KEGG" id="ovi:T265_05797"/>
    <dbReference type="CTD" id="20319979"/>
    <dbReference type="OrthoDB" id="8916892at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="756" mass="81815" checksum="4696EA6A1FAA083C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV25</accession>
    <name>A0A074ZV25_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166608.1">
        <property type="nucleotide sequence ID" value="XM_009168344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV25"/>
    <dbReference type="STRING" id="6198.A0A074ZV25"/>
    <dbReference type="GeneID" id="20327487"/>
    <dbReference type="KEGG" id="ovi:T265_13320"/>
    <dbReference type="CTD" id="20327487"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="202" mass="22308" checksum="21F99FD5902710EE" modified="2014-10-01" version="1" fragment="single">MFTRKMTLLSSNMAEVPMLFLGFCLVDGETARWLERGFTDWKGRGSNPTSASRLPLLRLGQPSSIPALELIERNQCVELGFHGLTRLLMDATLRPQPGDPVHSRLCHHPRIATPQFLHTRLGQKLNGLVTLIECERLRCSRFQNVALRSLDSCSVATDFVGVLGHVTTASADLVACLVEPNIERLCDPPGTAGLSQFSISWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVA0</accession>
    <name>A0A074ZVA0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166492.1">
        <property type="nucleotide sequence ID" value="XM_009168228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVA0"/>
    <dbReference type="STRING" id="6198.A0A074ZVA0"/>
    <dbReference type="GeneID" id="20317873"/>
    <dbReference type="KEGG" id="ovi:T265_03686"/>
    <dbReference type="CTD" id="20317873"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15794" checksum="02283A2450D3D0D5" modified="2014-10-01" version="1">MAEDNERAYATVVQVYSPLQLVKPTGVTHMKGDVVTKPEYESRHAEWFHQKEKQANFRTSSHHSLPTALRRIMAWAVSIRKAYTKTKRSSEDSPLGARKTDTAILEGQQNRFPLGNSSADPKLMVHSMVVMVPWTLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVL0</accession>
    <name>A0A074ZVL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164749.1">
        <property type="nucleotide sequence ID" value="XM_009166485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVL0"/>
    <dbReference type="GeneID" id="20316469"/>
    <dbReference type="KEGG" id="ovi:T265_02281"/>
    <dbReference type="CTD" id="20316469"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="8922" checksum="DC0379D31534BD78" modified="2014-10-01" version="1">MLSKKMEKRYPRDEAIMMNAHQKSVQHDSKKPRVKRLPTKGSQSGISPGQPAPREKLISQPRQLSDSCPLRGLLCNVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWD6</accession>
    <name>A0A074ZWD6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166061.1">
        <property type="nucleotide sequence ID" value="XM_009167797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWD6"/>
    <dbReference type="STRING" id="6198.A0A074ZWD6"/>
    <dbReference type="GeneID" id="20317523"/>
    <dbReference type="KEGG" id="ovi:T265_03336"/>
    <dbReference type="CTD" id="20317523"/>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="539" mass="60468" checksum="BBF666ED7418BE7E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWH2</accession>
    <name>A0A074ZWH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164450.1">
        <property type="nucleotide sequence ID" value="XM_009166186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWH2"/>
    <dbReference type="GeneID" id="20316226"/>
    <dbReference type="KEGG" id="ovi:T265_02038"/>
    <dbReference type="CTD" id="20316226"/>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="454" mass="52500" checksum="00AF6C9364897A97" modified="2014-10-01" version="1">MNHIYPLIGGTDDENDCDSVDSNGPLTTAQECKVWRNPYSLFRGAEYQRFFRETNRDPLTYYDMNLSAQDHQTFFTCEADAGRPEYELMQMAWRERNHEERLKKTKEALTKNPECATAMILLAEEECSHIVEVEKMYKQAHKVAEAALRRSQQTQNHSPAHEAMYHRDIHVYVFIRRRQAMCARKLGKLKEAIKMMKDLIKDYPNLNLFNIHENLIECYLAAQQYADAQAFLAKYDDIHYPKSATICYTAALLKARQVADKFSPDIASRRGLTPAELSAVEAIHRAVEFNPHVPKYLLEMKPLILPTEHILKRGDSEAIAYAFFHLAHWKAVEGALNLLYCTWEGTFRLIPYPLEKGNLFYPYPHSATATDRELLPSFHNISVYPKKEVPFFILFTAALCSLTAVLACLTHVYPEHMGMLSKKTILWFFSPINYMLDKLESFLLFISPSSPRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX36</accession>
    <name>A0A074ZX36_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168314.1">
        <property type="nucleotide sequence ID" value="XM_009170050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX36"/>
    <dbReference type="STRING" id="6198.A0A074ZX36"/>
    <dbReference type="GeneID" id="20319308"/>
    <dbReference type="KEGG" id="ovi:T265_05126"/>
    <dbReference type="CTD" id="20319308"/>
    <dbReference type="OrthoDB" id="10657112at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="290" mass="32359" checksum="EFA6B8E25598DEAB" modified="2014-10-01" version="1">MFIMIPRASLLPSAENLMGGAPPFFRLCFEGERKPPNEHKHPDAGRLSETFDAVYQHANPPGNVHSTRRSRCSKNAKALVTTRKNSVRTRMHYGGDEAEEGEVYDGSDQEEADSDQNATSDASPRHPKFTSQGQRLPMRPGVASGYLKSDPHYRRYPIPHGPVTRTFPLSRSTDHLPPIRPVHHDTGTRVYEAPENNSYDGRSQTNQNDRSHPAEPNVPYSHERLGPPPHYPPRPELPNGPPPLPFPKPQLPGLPAPPLTAVGSQEEIERFSRISVKVSEMAQLVRAQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXJ4</accession>
    <name>A0A074ZXJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597117">
        <property type="protein sequence ID" value="KER19929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176332.1">
        <property type="nucleotide sequence ID" value="XM_009178068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXJ4"/>
    <dbReference type="GeneID" id="20329595"/>
    <dbReference type="KEGG" id="ovi:T265_15430"/>
    <dbReference type="CTD" id="20329595"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="432" mass="49394" checksum="A3E54B8BE27E729C" modified="2014-10-01" version="1">MDNVWQNAKVAELEAFSDVRPISQIPPNDYWISRSRNAWVLLAFQDGDCMILTVPGWRHYKIWLSTDVNGVLVASFYPDCLSEHLEVLTELFEVQFSWPPATQNLETVHKDERNVNLNCSSEEMKYKISALKRGKASGPDRLNPALFKGGEYLMIYLAKQIGAIRYKEKVPTEWVTSTIIFVFKKRTRTLLGLNPTSPVLGQPGSIPALVLPSGGMAAKHRKMIQLNDYQLPSVTKRLDLTVLVNPPVWGLEHGVRWLKWLEREFTDLNVRGTNLAVSQPSCFLRVAWRLGTDRVLQLNDLSFIYLEHTFESKALVEDPSSSTFPSELTQLPKYVRLPTTSGDSPSMVRDMFNDCMSWSMTLHFEFSARTSKSRIKFANLRHLWRLHVPGYSKGCVVIWVRDVATESRCDASSDFRPPMPQKRCCFWMTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZE2</accession>
    <name>A0A074ZZE2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163809.1">
        <property type="nucleotide sequence ID" value="XM_009165545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZE2"/>
    <dbReference type="GeneID" id="20315692"/>
    <dbReference type="KEGG" id="ovi:T265_01504"/>
    <dbReference type="CTD" id="20315692"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33060" checksum="00F75040DA9F6FB5" modified="2014-10-01" version="1">MGILDLLRQRRTMERAKTWRQATIASNILLIITGFIVCISVLAMYINPRWLSLIQSINQLVDMHVKLGALILFGLLYTLAGLAALRSLKVRSTFLLGLQIFAVLILTVVVLATLYAVASQWIATMPTGVSFSVQGFKPGDPKNMAMANIQSVLKCCGRESYRDYYIANEAIPIRWVPFSCCNLNEHSYATCKNVSKPVHRGKLGRWFDPVPPSPDATVVPESFSYTNGCEWLIQHCLLPLLFLGFIVPSLCALISCTFASVYLHFAEKEDPDFDRPLDLSMFTFISGVKNERKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZF6</accession>
    <name>A0A074ZZF6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163823.1">
        <property type="nucleotide sequence ID" value="XM_009165559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZF6"/>
    <dbReference type="STRING" id="6198.A0A074ZZF6"/>
    <dbReference type="GeneID" id="20315706"/>
    <dbReference type="KEGG" id="ovi:T265_01518"/>
    <dbReference type="CTD" id="20315706"/>
    <dbReference type="OrthoDB" id="10070774at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="353" mass="40479" checksum="DD801969FF7E93FF" modified="2014-10-01" version="1">MSDSSIRLQTYVVCGVMIGCFSLLYPRIFHPMLMHALGFSKAASSDADSHHLNRPPFDPHGAFNRPRPSIRAVDAETQKPSGKRGGLMSVVLPVYAVGIVLYLIYTLSKIYRSRNRKNNDHKEEFLRHYYRDFHYDTRHGKFRMGHGSSDEGEEDEESEDIPKGSLGLLSSTRASRLGKPKFTNKDGRFDWAAAYGAEGQRDIFRSAKSLPRDLEALLLKIESEDVVNHDEFTALRIRLEQTEKEMTRLLSAMNQAERMVGRLDVDDDVDPQQLDRHAAPGPAQEDTEYEATASEDELGKFCYQLDLNTRILKILQCSPHFMNNVTKQKWKVDFLVEHELLRHILLRKRVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZQ4</accession>
    <name>A0A074ZZQ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167504.1">
        <property type="nucleotide sequence ID" value="XM_009169240.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZQ4"/>
    <dbReference type="GeneID" id="20327682"/>
    <dbReference type="KEGG" id="ovi:T265_13515"/>
    <dbReference type="CTD" id="20327682"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
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            <end position="342"/>
        </location>
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        </location>
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        </location>
        <ligand>
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            <position position="1"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Gao S."/>
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                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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            <end position="39"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
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                <person name="Tan P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="803"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="HATC_C_dom"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_BED"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1511" mass="164955" checksum="CABA09F33F253D70" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A349</accession>
    <name>A0A075A349_OPIVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_03485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_03485"/>
    <dbReference type="CTD" id="20317672"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18471" checksum="9292BD91B9FD0C03" modified="2014-10-01" version="1">MTARFRGQPHPTNLPEPPCAPVVCNRAVTRFRKKLEARLPKWLEREFTDRKVSGSNPTSASRLPLSRLEQHVSIPAPVARQRVTELSKISHSTYTVHSTPYGSKHLGVLRARRLKCLEREFTDRKVRGSNPTSVSRLPLSRLRQPGSIPAPVPPSCDTAVKACYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A398</accession>
    <name>A0A075A398_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation initiation factor 5A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-5A family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A398"/>
    <dbReference type="STRING" id="6198.A0A075A398"/>
    <dbReference type="GeneID" id="20324077"/>
    <dbReference type="KEGG" id="ovi:T265_09909"/>
    <dbReference type="CTD" id="20324077"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="8">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21017" checksum="E9D3611136C85CC2" modified="2014-10-01" version="1">MAHFDDDDFDVVDTGASATKPQQCSSLRVNGFVVMKGRPCQITSMSVSKTGKHGAAKVHLVGVDIFTGKKYELQDSSTATIAVPNISRKEYQLIDIKDNFLSLMGDDLSVRENIPLPEGEVGKEIMEKWENKGDEDVVTLVGSTGQKKPGVSEMTERQFTPYIVVSDGLCTLKDITAGLLQHNRWENPAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3D8</accession>
    <name>A0A075A3D8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163499.1">
        <property type="nucleotide sequence ID" value="XM_009165235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3D8"/>
    <dbReference type="GeneID" id="20315438"/>
    <dbReference type="KEGG" id="ovi:T265_01250"/>
    <dbReference type="CTD" id="20315438"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="10175" checksum="610637181EB407F6" modified="2014-10-01" version="1">MLTRMTHHSRGSIPIIAQEKNGYHQRFRTSDKLDMDEDMEEELLSSREYSSHGRVKHVARIKANCGTNSLKQLMNEEVSFSRSLVPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3E8</accession>
    <name>A0A075A3E8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161966.1">
        <property type="nucleotide sequence ID" value="XM_009163702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3E8"/>
    <dbReference type="STRING" id="6198.A0A075A3E8"/>
    <dbReference type="GeneID" id="20314233"/>
    <dbReference type="KEGG" id="ovi:T265_00045"/>
    <dbReference type="CTD" id="20314233"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="287"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="807" mass="89637" checksum="76BD4B85F02F7E80" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3Y5</accession>
    <name>A0A075A3Y5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162285.1">
        <property type="nucleotide sequence ID" value="XM_009164021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3Y5"/>
    <dbReference type="GeneID" id="20326665"/>
    <dbReference type="KEGG" id="ovi:T265_12497"/>
    <dbReference type="CTD" id="20326665"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="395" mass="45339" checksum="48E1A82D732A1442" modified="2014-10-01" version="1" fragment="single">LLTRWLKWLEREFSDRKVRGSNPTSATRLPLSRLGQPDSIPALVLPSGGMAARHRKGATAERLLLLLHSYWCFRKSLRMNRAKRYRSLFSSTLPVPSCHPKGRRHEGCDSARLPRPRQERLSCRDQIRTTDLPVRKLQSYLQTANYCREITIIITQKCYSHNKPHYIKVNGMKTMHNDSLEKADDLPYWPVRKQGLAYPSVDNHQCRRLKRITWFGTTLLAICSLTTSHRYRAGQKVLCEVDGPTKMKSFSCDTLPVPNCHATRRKHEGWDTVRLPKPRQGKSRGGGRVRTTDLPVLQSPKTSNTINRSGSVTSYAFPKTIHRDECCSPIRNRLRDSWLRRETADWKAHGSNRTPASRSLLSRVGNPDEISDHVLPSNGMVARHRKHVTDELLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A445</accession>
    <name>A0A075A445_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165876.1">
        <property type="nucleotide sequence ID" value="XM_009167612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A445"/>
    <dbReference type="GeneID" id="20317380"/>
    <dbReference type="KEGG" id="ovi:T265_03193"/>
    <dbReference type="CTD" id="20317380"/>
    <dbReference type="OrthoDB" id="6247845at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="306" mass="33892" checksum="4F0D0A776CF29555" modified="2014-10-01" version="1">MINLLELLALPNMMSYVVTLNVRFQSLTKSIKASEAANARTLDPLVKNLYKMVPSTLVTFLVAIGFHTCSSSSVSNAANQLDIWCGADGQNFAQPSNSCFYTKNISAVPLYRLVNHYADSMAANEPKSGMFSNECCSYHMHVHFAWRQADVRLSRVALALQNNRWKIVGSNLVSSIGTLIELPAKGTIGELLDFLFGCYCFAVPQSTIVGDATVYVSNFRSSRSSTIDQALLTETTQNFLKLAAPGSYYLAWSDAPEMVRVFTALKYEQLICGDTPMGKNPCHWSRVGMDDEEAKSRCLYRIQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A548</accession>
    <name>A0A075A548_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_02933</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165561.1">
        <property type="nucleotide sequence ID" value="XM_009167297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A548"/>
    <dbReference type="STRING" id="6198.A0A075A548"/>
    <dbReference type="GeneID" id="20317121"/>
    <dbReference type="KEGG" id="ovi:T265_02933"/>
    <dbReference type="CTD" id="20317121"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="443"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="650"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="699" mass="77128" checksum="004C859D257F0AD3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6T7</accession>
    <name>A0A075A6T7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RHO protein GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164906.1">
        <property type="nucleotide sequence ID" value="XM_009166642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6T7"/>
    <dbReference type="STRING" id="6198.A0A075A6T7"/>
    <dbReference type="GeneID" id="20316597"/>
    <dbReference type="KEGG" id="ovi:T265_02409"/>
    <dbReference type="CTD" id="20316597"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9175" checksum="8EA7A025C1A90499" modified="2014-10-01" version="1">MTLEFQITSPPSRSTFDRSSAMMGSYAPQNEVRVWKSDTFEAPKGAMHRGTYHIKSRFVDADKNEYVSWKWDIQVVKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7X9</accession>
    <name>A0A075A7X9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172675.1">
        <property type="nucleotide sequence ID" value="XM_009174411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7X9"/>
    <dbReference type="GeneID" id="20322745"/>
    <dbReference type="KEGG" id="ovi:T265_08566"/>
    <dbReference type="CTD" id="20322745"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="276" mass="30779" checksum="2CBC3973E4DB1711" modified="2014-10-01" version="1">MRPVTSDVHFLLEGYDASDGVVEDENDTPTNFSTKSTSRVGDLPSGPGYWCVKAKVRMVYKLVPGYKWSFLACSVCGPGAHAMWNAASTVLTTIRPIFLSGVPHKVDCCQILTNQNRDDAASRVIAATSEAMADEVQSRMCANNFQMTSIKTNRNKMTTDEGGFQSTHICKEVNILTLKFLFRPQGFCRKIHCASSRWRRDQEISVTLMIDQLARVVDRKRQPGRLKTNTVFIGVKRGSCSPRSSATFPSKEDGIQSFSPGCYPHLIQQDHQPDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7Z2</accession>
    <name>A0A075A7Z2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carrier protein PET8 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_02036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164448.1">
        <property type="nucleotide sequence ID" value="XM_009166184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7Z2"/>
    <dbReference type="STRING" id="6198.A0A075A7Z2"/>
    <dbReference type="GeneID" id="20316224"/>
    <dbReference type="KEGG" id="ovi:T265_02036"/>
    <dbReference type="CTD" id="20316224"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="84"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="194"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31926" checksum="F4E42D8F492D1EFB" modified="2014-10-01" version="1">MFEYNLKAFLAGATAGLCVDVSLFPIDTIKTRIQSAQHSIQRVPGNQRLFAGLPAVLVGSAPGAAVFFLTYEFVKNEVYSVGMPPICSSVWAACLAEVAACVVRVPCEVLKQRAQNSPHLAMRAIFSRAVNTEGVFGLYRGYLSTVLREIPFSFIQFPIWEHLKLLTIRWNQRHQPQGHPVSGFANPHELHFWQSALCGSLSGAIAGALTTPLDVAKTRIMLAEAHTPLASGNIVTALKTVFRELGLRGLFRGIVPRVSYLALGGAIFLGMYDTSYRLWNRVIHTMPSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8W6</accession>
    <name>A0A075A8W6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172266.1">
        <property type="nucleotide sequence ID" value="XM_009174002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8W6"/>
    <dbReference type="STRING" id="6198.A0A075A8W6"/>
    <dbReference type="GeneID" id="20322433"/>
    <dbReference type="KEGG" id="ovi:T265_08254"/>
    <dbReference type="CTD" id="20322433"/>
    <dbReference type="OrthoDB" id="189655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70861" checksum="14EDFD55FF8D3220" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8X0</accession>
    <name>A0A075A8X0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164116.1">
        <property type="nucleotide sequence ID" value="XM_009165852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8X0"/>
    <dbReference type="GeneID" id="20315950"/>
    <dbReference type="KEGG" id="ovi:T265_01762"/>
    <dbReference type="CTD" id="20315950"/>
    <dbReference type="OrthoDB" id="10543289at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705454" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="18448" checksum="2DEC409BD88034FF" modified="2014-10-01" version="1">MNKMIFLMTRSVMTDFLIAVCPHTVYCPEGGTPYYRKSGPICFVPKPVAPSTANKCIHAPRVTLNSQCYVIAPSAGPTSNYSLTSCFIALQEAEAFIATANGLSTLPSVSPVELLSHGPEATDAARLLAIATTTPEADSTCARHRPHDLPSLRVTPVSKYACELGYLSSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A911</accession>
    <name>A0A075A911_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163955.1">
        <property type="nucleotide sequence ID" value="XM_009165691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A911"/>
    <dbReference type="GeneID" id="20315813"/>
    <dbReference type="KEGG" id="ovi:T265_01625"/>
    <dbReference type="CTD" id="20315813"/>
    <dbReference type="OrthoDB" id="6314131at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10497" checksum="DAD21C5BAC33AA1A" modified="2014-10-01" version="1">MAMISGDPSNLGDPRCPNSDEQALITELVGIVLPGKSVDVFYIRPHGGDKALHFQLMTRHDGSNCTLANVFGTNPVGQRLTVVQKDAECPSSAICGPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9U7</accession>
    <name>A0A075A9U7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171945.1">
        <property type="nucleotide sequence ID" value="XM_009173681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9U7"/>
    <dbReference type="GeneID" id="20322179"/>
    <dbReference type="KEGG" id="ovi:T265_08000"/>
    <dbReference type="CTD" id="20322179"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="21262" checksum="700FC88DC290077E" modified="2014-10-01" version="1">MFRRVRALCTEEIDRMAAQIEIANKLQEIGYPAIVCGENGAHFEVTDHEHWRREPWRNNQRQSASRHEVSVQKCLAEQVADEGKRPRVIGADQFGGDKCEDLEWKSIRRRHNAVIEVFGKERKHRKVIDVNILLPVCQSLQVRLYCTYLRAPTPMENRPTGYRTRIIQAAGKSATRVSPLSDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAH3</accession>
    <name>A0A075AAH3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">T265_14394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596805">
        <property type="protein sequence ID" value="KER24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171693.1">
        <property type="nucleotide sequence ID" value="XM_009173429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAH3"/>
    <dbReference type="GeneID" id="20328560"/>
    <dbReference type="KEGG" id="ovi:T265_14394"/>
    <dbReference type="CTD" id="20328560"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="636" mass="72379" checksum="933962CC262DC19D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB48</accession>
    <name>A0A075AB48_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163127.1">
        <property type="nucleotide sequence ID" value="XM_009164863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB48"/>
    <dbReference type="STRING" id="6198.A0A075AB48"/>
    <dbReference type="GeneID" id="20315136"/>
    <dbReference type="KEGG" id="ovi:T265_00948"/>
    <dbReference type="CTD" id="20315136"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="73804" checksum="8FBB76BA4C6960B8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACV3</accession>
    <name>A0A075ACV3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162410.1">
        <property type="nucleotide sequence ID" value="XM_009164146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACV3"/>
    <dbReference type="STRING" id="6198.A0A075ACV3"/>
    <dbReference type="GeneID" id="20326678"/>
    <dbReference type="KEGG" id="ovi:T265_12510"/>
    <dbReference type="CTD" id="20326678"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="39676" checksum="E2DDD621014AC54A" modified="2014-10-01" version="1">MVSSTEVCISEEEAALYDRQLRLWGVEAQNRLKRSRILLLGMTPLAAELAKNLVLVGIQSLTVVDDVLATEEDVSCNFLIPCEAVGKPVIAPIPADYSLKRSTAALPRIQALNSMVRVSALSAGCNNPIQEGHTYDVVILTSSCLESDISNWIALKNNLRKSTGQVPGAHIVLASTMAFFGVAFLDLGYHEFMAEEVLPKKRPAPSATGVKKSQAASGTESTFVKKVARYSDLQDCLDMTWSSTGTCPSLSPKSMPKGFLLLEVLRRCTIADLPLNVEFLKSVWTSVSATLGVDSGFLSDEEFACCCGAPSPSVNAVLGGVVAQEIVRAITGKGAPYGNWYFFNGLQCSMTVEWLPKEDICPAPTTNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD10</accession>
    <name>A0A075AD10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170448.1">
        <property type="nucleotide sequence ID" value="XM_009172184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD10"/>
    <dbReference type="STRING" id="6198.A0A075AD10"/>
    <dbReference type="GeneID" id="20320989"/>
    <dbReference type="KEGG" id="ovi:T265_06810"/>
    <dbReference type="CTD" id="20320989"/>
    <dbReference type="OrthoDB" id="6262889at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="803"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="892" mass="98393" checksum="BFBCB769954180B1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADB0</accession>
    <name>A0A075ADB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162239.1">
        <property type="nucleotide sequence ID" value="XM_009163975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADB0"/>
    <dbReference type="STRING" id="6198.A0A075ADB0"/>
    <dbReference type="GeneID" id="20314455"/>
    <dbReference type="KEGG" id="ovi:T265_00267"/>
    <dbReference type="CTD" id="20314455"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="24381" checksum="EABC37CE62DADE4C" modified="2014-10-01" version="1">MKLVGPPQLPATRNFQPSHTLVSLIQHCSAEVSLFAHGNIPGHYVFQQPTNTLQDNPSLEMPTDVYLYPSLQPKVTGALQPLRAMQAVQPSADEIGKQFAAQYYQTLQTSRPAIRNFYHFPVINCPQEQARMIYEGDEVVGRENIAQKLQNIKCNTLQFALSSVDAQPCGNAILILVCGQLQSDEDRPLPFSETFLLTPIDSSLLVCNSMFRLNLHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADL9</accession>
    <name>A0A075ADL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170106.1">
        <property type="nucleotide sequence ID" value="XM_009171842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADL9"/>
    <dbReference type="GeneID" id="20320725"/>
    <dbReference type="KEGG" id="ovi:T265_06546"/>
    <dbReference type="CTD" id="20320725"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7694" checksum="7C82831A5E04B6A4" modified="2014-10-01" version="1">MNGLSRHHDLCRGVTIIDIHLSTRIQLSNSERAPDQVPVNPRVLEHRVRVHRKITVPGSMNVGPPRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADQ3</accession>
    <name>A0A075ADQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphate carrier protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170082.1">
        <property type="nucleotide sequence ID" value="XM_009171818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADQ3"/>
    <dbReference type="STRING" id="6198.A0A075ADQ3"/>
    <dbReference type="GeneID" id="20320714"/>
    <dbReference type="KEGG" id="ovi:T265_06535"/>
    <dbReference type="CTD" id="20320714"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="184"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER26184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42613" checksum="019E7109654341CF" modified="2014-10-01" version="1">MRILALASILPRAENIKSSATPFFHLCLSGERQPLTDKNKTDPGNLGKCFDPVYQIVNPSNVDAALLAPTDTMSSGSQVSCEYGTAKYYGLCSLGGVLSCGTTHTALTPLDLVKCRIQVDRAKYKNITNGIRVTVAEGGIRGLGRGWAPTAIGYSLQGLGKFGFYEVFKHLYNGMLSEENAYLWRTTVYLAASASAEFFADIMLCPMEAVKVRIQTMPGWANTLREGVPKMLKDEGLFGFYKGIVPLWGRQIPYTMMKFACFERTVEALYKYVVPKPRDDCSKAEQLVVTFAAGYIAGVFCCIVSHPPDTIVSKLNKDPNARLVEVAKNLGLLGMWSGIGPRIIMIGTLTALQWFIYDGFKVAMALPRPPPPVMPVSLREKLEHRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEC5</accession>
    <name>A0A075AEC5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169655.1">
        <property type="nucleotide sequence ID" value="XM_009171391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEC5"/>
    <dbReference type="GeneID" id="20320372"/>
    <dbReference type="KEGG" id="ovi:T265_06190"/>
    <dbReference type="CTD" id="20320372"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7332" checksum="3AD3B5D1C5F19C51" modified="2014-10-01" version="1">MARPKNTNSANEIKKPHLKFFHNGGYNSGAARFPTTSVNVSSQVQSLSFGPKRLAALCGCKHTGRNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AED2</accession>
    <name>A0A075AED2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dual specificity phosphatase, catalytic domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169591.1">
        <property type="nucleotide sequence ID" value="XM_009171327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AED2"/>
    <dbReference type="STRING" id="6198.A0A075AED2"/>
    <dbReference type="GeneID" id="20320316"/>
    <dbReference type="KEGG" id="ovi:T265_06134"/>
    <dbReference type="CTD" id="20320316"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF6">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="251"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="314"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50970" checksum="E719CA03361F215F" modified="2014-10-01" version="1">MDRFSTTYSRSYRPFDEFQRNIPLRCLNGTQTSSTILNGSRSPGVARLARCWPSDLPTSQTTSFASSIGDTCSSTSTYAIYQPPFTRSANDDDSPGFALPWDVSKPIIDKQRPTPPGMCASSTTANRLGFSFDDTVTSGLSSISTCATNKDCTSSCSTVISADKLNACHGLSNGVTEDLTFATKTPLLFCAPQARTLPTISNAIGCNSDIGSDLTHGNCRKIPVTTERALTVNPTSPPPGSQLDFSQMYSQVARINNHLYLSSLNALTPDRLRQYGITLLVSAMVDPPPAQLRNAVISSMHVPVEDMEGANLRAHFDRVGDRIASEQRRGGRTLVHCMAGVSRSSSLVLAYLMRHMNMTLADAYQHVRSIRPCIQPNPSFWRQLLEYEERIHGRRSVRLLPPVGYMGSCGISPTSRLYAGDRPSPRTSHLDMYSRPTSDLLPYRPITSVHSLDSGKPYIGCRQPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGY8</accession>
    <name>A0A075AGY8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microtubule-associated protein 1A/B/S-like MBL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167054.1">
        <property type="nucleotide sequence ID" value="XM_009168790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGY8"/>
    <dbReference type="STRING" id="6198.A0A075AGY8"/>
    <dbReference type="GeneID" id="20318318"/>
    <dbReference type="KEGG" id="ovi:T265_04132"/>
    <dbReference type="CTD" id="20318318"/>
    <dbReference type="OrthoDB" id="5371837at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026074">
        <property type="entry name" value="MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057480">
        <property type="entry name" value="MAP1A/B/S-like_MBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF12">
        <property type="entry name" value="ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
        <property type="entry name" value="MBL_MAP1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microtubule-associated protein 1A/B/S-like MBL-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="974" mass="103746" checksum="4BFAFEAE1EE8EC3C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI40</accession>
    <name>A0A075AI40_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Platelet-derived growth factor (PDGF) family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165220.1">
        <property type="nucleotide sequence ID" value="XM_009166956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI40"/>
    <dbReference type="GeneID" id="20316842"/>
    <dbReference type="KEGG" id="ovi:T265_02654"/>
    <dbReference type="CTD" id="20316842"/>
    <dbReference type="OrthoDB" id="6241716at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="82130" checksum="0610F26002C7DB3A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIZ5</accession>
    <name>A0A075AIZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163668.1">
        <property type="nucleotide sequence ID" value="XM_009165404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIZ5"/>
    <dbReference type="STRING" id="6198.A0A075AIZ5"/>
    <dbReference type="GeneID" id="20315566"/>
    <dbReference type="KEGG" id="ovi:T265_01378"/>
    <dbReference type="CTD" id="20315566"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="347" mass="39464" checksum="D1AE582C24F0E791" modified="2014-10-01" version="1">MVGTNQSSSKRKEIYKYDAPWCIFSLNWSVRPDRRFRLAIGSFIEEYNNEVQVICLDEDQGEFSVQSTFAHHYPTSKIMWIPDTKNQFPDLLATSGDYLRVWRVQEDNNVKFECRLNNNTNSDYCAPLTSFDWNEVDPNILGTSSIDTTCTIWALETQQALGHTNVISGHVESQLIAHDKEVYDIGFSRMGTGREMFASVGADGSVRMFDIRNLKHSTIIYEDANHAPLLRLAWNKQDSNYLATFAMDSVEIIILDLRVPCTPVARLNSHRAYVNGLAWAPHSSCHLCTASEDCQALIWDIQSMPRAIEDPILAYTAAGEINQIQWSSTQPDWIAICYNSSMEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ97</accession>
    <name>A0A075AJ97_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163295.1">
        <property type="nucleotide sequence ID" value="XM_009165031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ97"/>
    <dbReference type="GeneID" id="20315276"/>
    <dbReference type="KEGG" id="ovi:T265_01088"/>
    <dbReference type="CTD" id="20315276"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11506" checksum="EBA7672FA06E47C2" modified="2014-10-01" version="1">MRQSKITATRGISYGGAYEASNKLIRQHKQQRKITLPYIRKVAEMTERHLRQHGIAVAFRPTNTLRTLSKPKGVTPINSQLLYGADTPDDIASAFFITTAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJM6</accession>
    <name>A0A075AJM6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162606.1">
        <property type="nucleotide sequence ID" value="XM_009164342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJM6"/>
    <dbReference type="GeneID" id="20314726"/>
    <dbReference type="KEGG" id="ovi:T265_00538"/>
    <dbReference type="CTD" id="20314726"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9029" checksum="CF2428A1859B6863" modified="2014-10-01" version="1">MLTKDCSTTEQMDLALISVHAAYLGRCWEAQSGEVVTDPITMLTEAKAPCGGDPVSKPRDSRNRGRKKISQPNWMMTQLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJP2</accession>
    <name>A0A075AJP2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162454.1">
        <property type="nucleotide sequence ID" value="XM_009164190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJP2"/>
    <dbReference type="STRING" id="6198.A0A075AJP2"/>
    <dbReference type="GeneID" id="20314605"/>
    <dbReference type="KEGG" id="ovi:T265_00417"/>
    <dbReference type="CTD" id="20314605"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="669"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="671"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="707" mass="73065" checksum="7BD053482CDB3C18" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTS8</accession>
    <name>A0A074YTS8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607648">
        <property type="protein sequence ID" value="KER18176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178077.1">
        <property type="nucleotide sequence ID" value="XM_009179813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTS8"/>
    <dbReference type="GeneID" id="20330407"/>
    <dbReference type="KEGG" id="ovi:T265_16242"/>
    <dbReference type="CTD" id="20330407"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7359" checksum="F93F624BCA6DEEE4" modified="2014-10-01" version="1" fragment="single">MVEKNILRRENDDGFVYYLVVQINGHLPSQYTDWGHSQSVQTQLTNQVQENRANAHVKSGNDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVI2</accession>
    <name>A0A074YVI2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598878">
        <property type="protein sequence ID" value="KER18658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177595.1">
        <property type="nucleotide sequence ID" value="XM_009179331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVI2"/>
    <dbReference type="STRING" id="6198.A0A074YVI2"/>
    <dbReference type="GeneID" id="20330076"/>
    <dbReference type="KEGG" id="ovi:T265_15911"/>
    <dbReference type="CTD" id="20330076"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER18658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6994" checksum="957C8BB14A742659" modified="2014-10-01" version="1" fragment="single">MEYAKNGEVFDHLLRIGRMPEKEAQKLFRQLFSAVEYCHQKNIVHRDLKVSKRSSVSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWE7</accession>
    <name>A0A074YWE7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597339">
        <property type="protein sequence ID" value="KER19091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177163.1">
        <property type="nucleotide sequence ID" value="XM_009178899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWE7"/>
    <dbReference type="GeneID" id="20329829"/>
    <dbReference type="KEGG" id="ovi:T265_15664"/>
    <dbReference type="CTD" id="20329829"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="53" mass="6060" checksum="744A849E7F716748" modified="2014-10-01" version="1" fragment="single">MIPSYCDAYELFPFIYQIIIIPRAILAGTDDATMPGRPKQSSQNRSSETPYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWP7</accession>
    <name>A0A074YWP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597298">
        <property type="protein sequence ID" value="KER19186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177070.1">
        <property type="nucleotide sequence ID" value="XM_009178806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWP7"/>
    <dbReference type="GeneID" id="20329793"/>
    <dbReference type="KEGG" id="ovi:T265_15628"/>
    <dbReference type="CTD" id="20329793"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="248" mass="28291" checksum="16DD789A5DA616F4" modified="2014-10-01" version="1" fragment="single">MSRSDQFYLMDRRRDRCVLKTFESCLTTGASEALRESGGNITFVMLTHGGWLFRESIFPRKKRLFHRLRWLGHILHMPDGCLLHTARYARQRMEKTQGWAIPQITLARPQTSYARWLFASYSPLRPATDGKDSGVVSPRPGMRDLASKLSRVGKWLSRMGRVKENKPMWMSENTLFTSSFTPATDGKDSGVVSPRPGMRDLASKLSRVGKWLSRMGRVKENKPMIDSYLQKSFRCSAVLIGQEAACPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXF8</accession>
    <name>A0A074YXF8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Legumain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597195">
        <property type="protein sequence ID" value="KER19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176767.1">
        <property type="nucleotide sequence ID" value="XM_009178503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXF8"/>
    <dbReference type="GeneID" id="20325924"/>
    <dbReference type="KEGG" id="ovi:T265_11756"/>
    <dbReference type="CTD" id="20325924"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703645" description="Legumain" evidence="2">
        <location>
            <begin position="30"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33535" checksum="77D4436406B0E870" modified="2014-10-01" version="1">MKFQVILNMMRRCSFLIALLLCIDHVAWLEAIGIHNWSSLFNNNPSKNWVVLAAGSKSWGNYRHQADVYHAYQLVRKNNVPPENIITFAYDDIANNPSSPLSFSLTRAQKDIKKRTLEEQYEEVKRNTKSSHVMKYGEMAMGSLPVGKFQGHYDLLMNRNGGVIALGHIVKDTFRDFVEHVKTNHKPTLKGLSKRDELMCFKTVFDQFRTHCFTIQQPNAVGRKPSCQAHLISKTRRLIQAATEEEHETAWRKLHRALQVPEVAQHTTHLMELCKAGYEAETLIDSVRNICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ35</accession>
    <name>A0A074YZ35_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597099">
        <property type="protein sequence ID" value="KER20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176197.1">
        <property type="nucleotide sequence ID" value="XM_009177933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ35"/>
    <dbReference type="STRING" id="6198.A0A074YZ35"/>
    <dbReference type="GeneID" id="20329569"/>
    <dbReference type="KEGG" id="ovi:T265_15404"/>
    <dbReference type="CTD" id="20329569"/>
    <dbReference type="OrthoDB" id="6287242at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="25905" checksum="847E1EA5E50DBB81" modified="2014-10-01" version="1" fragment="single">MIWTKLAVETTHKVAENYLAAHDRFRPPASGSSGWRCTRVFVKLMFHSNPNCTVFEKYTHLQVDLVFTRDLNESLAASCFSWHDIRYIAVYFHTGNYSQDMRFPPTGCVELYFSSDPILLQEHNDNLDRGGYQWTSADRESSILSVGIGGERQRVLPRHGILVTDQTRRDRTFPAVEQQKLIETRKPLSILITTQEYIITAPSALFTGQIQITQAPMWSDAGIHGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z018</accession>
    <name>A0A074Z018_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175986.1">
        <property type="nucleotide sequence ID" value="XM_009177722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z018"/>
    <dbReference type="STRING" id="6198.A0A074Z018"/>
    <dbReference type="GeneID" id="20329525"/>
    <dbReference type="KEGG" id="ovi:T265_15360"/>
    <dbReference type="CTD" id="20329525"/>
    <dbReference type="OrthoDB" id="6261948at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13191" checksum="3E4264669141C747" modified="2014-10-01" version="1" fragment="single">MTLDDLFAKKAKKKTKKHNPQDLFEKLTKEVSKQHVQEGDVNSDNTKAIANLVKDDEWETIEDDEKEIDLQTIQLGNLALNVSGEPKQQSKDKSEKEGAGEAVEEKKVWGTKIPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z035</accession>
    <name>A0A074Z035_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-tubulin N-acetyltransferase</fullName>
            <shortName evidence="3">Alpha-TAT</shortName>
            <shortName evidence="3">TAT</shortName>
            <ecNumber evidence="3">2.3.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetyltransferase mec-17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-lysyl-[alpha-tubulin] + acetyl-CoA = N(6)-acetyl-L-lysyl-[alpha-tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15277"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.108"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase ATAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.108" evidence="3"/>
    <dbReference type="EMBL" id="KL597072">
        <property type="protein sequence ID" value="KER20278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175982.1">
        <property type="nucleotide sequence ID" value="XM_009177718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z035"/>
    <dbReference type="STRING" id="6198.A0A074Z035"/>
    <dbReference type="GeneID" id="20325308"/>
    <dbReference type="KEGG" id="ovi:T265_11140"/>
    <dbReference type="CTD" id="20325308"/>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial for catalytic activity" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="361" mass="41576" checksum="C2A26821AB4F617F" modified="2014-10-01" version="1">MEFAFRIRDFLNNEIAHLTPDLLNKPPFTHGNVNTTWNNIRELIDTMGEYSAHAQNLPHVVTNFKKFSASDHNLYVLSDVNLNRVIGFLKTGKKRLFMHDSQGLCTEAEPLCVLDFYIHESCQRKGHGKRLFDYMLQVENVAPPSLAIDSPSRKMLHFLSRHYHLDRPIFSSNNFVIYPGFFSFSNNIRKVYQDFRTVYSTNDRKTVLPYGDRSSPRKSRSSQLVRTVDNRVQPHHSTPHTEITVRSAMELTSPSQAKTDWKPSSLAHTNEQSITSTNPRNKTSKSIDSDCKNPEKSSKDDVDKNPSGHFPCIDTKARENYSVISSQELRLLRGLPDGRRTSHEYSYLNAVRNHNGHRKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z091</accession>
    <name>A0A074Z091_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597555">
        <property type="protein sequence ID" value="KER18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177361.1">
        <property type="nucleotide sequence ID" value="XM_009179097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z091"/>
    <dbReference type="GeneID" id="20326279"/>
    <dbReference type="KEGG" id="ovi:T265_12111"/>
    <dbReference type="CTD" id="20326279"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15224" checksum="83591ACF636BC37D" modified="2014-10-01" version="1">MHFRCPECVVSFRFFPQLTRPVYQVDITADDVMQVEFLLHTEPPNKMVASSKGATGPAQGLTNGVVEVSVNPSLKDFHCDWRFKCSKCELKSVAISGTKADKSINSFMVVKWAFAPHYYHGLACNIREEGTKRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0R0</accession>
    <name>A0A074Z0R0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597357">
        <property type="protein sequence ID" value="KER19057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177197.1">
        <property type="nucleotide sequence ID" value="XM_009178933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0R0"/>
    <dbReference type="STRING" id="6198.A0A074Z0R0"/>
    <dbReference type="GeneID" id="20329846"/>
    <dbReference type="KEGG" id="ovi:T265_15681"/>
    <dbReference type="CTD" id="20329846"/>
    <dbReference type="OrthoDB" id="6042339at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF30">
        <property type="entry name" value="MEMBRANE FRIZZLED-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER19057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="14127" checksum="09AADA701296DCE8" modified="2014-10-01" version="1" fragment="single">YAFLLVTATHDAVVQWRCSHILTNYTGIIESPNFPLDYPNLMTCSWRIGLPPGCTVKLNISSFDLEYNHDTLTIYDGYDNSSSPVVLTGYNFPDPFYSTGQYLYIEMETDREVQKSGFHATYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z170</accession>
    <name>A0A074Z170_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597030">
        <property type="protein sequence ID" value="KER20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175562.1">
        <property type="nucleotide sequence ID" value="XM_009177298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z170"/>
    <dbReference type="STRING" id="6198.A0A074Z170"/>
    <dbReference type="GeneID" id="20324987"/>
    <dbReference type="KEGG" id="ovi:T265_10819"/>
    <dbReference type="CTD" id="20324987"/>
    <dbReference type="OrthoDB" id="10020956at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="805" mass="87545" checksum="20D3135DF9F1A979" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1A7</accession>
    <name>A0A074Z1A7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597025">
        <property type="protein sequence ID" value="KER20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175496.1">
        <property type="nucleotide sequence ID" value="XM_009177232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1A7"/>
    <dbReference type="GeneID" id="20324933"/>
    <dbReference type="KEGG" id="ovi:T265_10765"/>
    <dbReference type="CTD" id="20324933"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14205" checksum="1480D6C20AEDAFA3" modified="2014-10-01" version="1">MVTGHAVRIGCGDLEHENECGDLSEEEMEYWSVLLSKLAARMQCFLLGNKMVNTCSREIHKKKGTNEVMESACFRPPVLEEESVAESEFDGVPWVLAKAADAAAAAASEGSGIGGGERAESRLTEIGGAACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1U6</accession>
    <name>A0A074Z1U6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597007">
        <property type="protein sequence ID" value="KER20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175296.1">
        <property type="nucleotide sequence ID" value="XM_009177032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1U6"/>
    <dbReference type="STRING" id="6198.A0A074Z1U6"/>
    <dbReference type="GeneID" id="20324778"/>
    <dbReference type="KEGG" id="ovi:T265_10610"/>
    <dbReference type="CTD" id="20324778"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11869" checksum="97B1D39D4B932D4B" modified="2014-10-01" version="1">MKGKNCFMYSGLVHKKAIGIKPEKYGKGIVLITKKPGYDHKPAKAVVRTKYVRGRRRTLQKIRNMICRQKYRRELKMLALRRASALMLNMKPTAPPTAKPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2A9</accession>
    <name>A0A074Z2A9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597164">
        <property type="protein sequence ID" value="KER19637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176622.1">
        <property type="nucleotide sequence ID" value="XM_009178358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2A9"/>
    <dbReference type="GeneID" id="20325816"/>
    <dbReference type="KEGG" id="ovi:T265_11648"/>
    <dbReference type="CTD" id="20325816"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="21963" checksum="527A4EFC81FDDA35" modified="2014-10-01" version="1">MNELREEQTNGLRLALQDVNLTMTYNQAELVVRMAGDTLVLLSGIANRTYCTLTYQNHRGGRAYKKHLRRCLGLTNNLTAMRRKHVSELAATYNCAWNGLTGMPNRRTTVHLQMSITIEPVSTNCAPHVTLKGGNGVIPGRLHIRVECDHATSDGKLIYPFSAYMWTGRSSDCGQQLSGRTSLVRRGQFTPVGERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2G0</accession>
    <name>A0A074Z2G0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596982">
        <property type="protein sequence ID" value="KER21236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175024.1">
        <property type="nucleotide sequence ID" value="XM_009176760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2G0"/>
    <dbReference type="GeneID" id="20324564"/>
    <dbReference type="KEGG" id="ovi:T265_10396"/>
    <dbReference type="CTD" id="20324564"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="17365" checksum="23C72433F9E3F413" modified="2014-10-01" version="1">MAISLNQWGSCAGTIAFTAYLPHSLPNPAPSGLTSPLQPNTSNCWVAGSPMKTPLAAASQVTFGSKARDRVAEQNPASFHCFVGRTFVPKAQEGPSFEPDPCPSRLPLSRLEQTDSIPALVQPSGGMAMVVGEMAQRLGSKFTDQKVYGSNPTSASRRALFRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z313</accession>
    <name>A0A074Z313_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174791.1">
        <property type="nucleotide sequence ID" value="XM_009176527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z313"/>
    <dbReference type="GeneID" id="20324386"/>
    <dbReference type="KEGG" id="ovi:T265_10218"/>
    <dbReference type="CTD" id="20324386"/>
    <dbReference type="OrthoDB" id="10030336at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="309" mass="33737" checksum="EC6D44A3899B2CCA" modified="2014-10-01" version="1">MTRGGVQLSAKWSKEHIFATPPNNLPNSTSLTVIGKRDLSSESSNLSKHYLGRDSPIVRNGSVRPIPSSGNPFRIPRSFSTYAEVELKPDISPRINGLRTNLPVNSVVSYQSSTNGARTAGEEKTDAEYDEFLQLANRQEAFKPVHKAPITSRPFADDQVGLWPGQSVPMKTLGSINLPRSTSAYSDSLFPSHDPQTKSLATTRNFGPILPMSTEDDNRSPWNKHSPFIVSDSSPYTTDAESQMLGTPITSVPKPIPPPPQRQSQSSRQASSGPLQLQGNDNSSEVQPPTHWSPSPSAVEGDTKQDQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3X3</accession>
    <name>A0A074Z3X3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL616387">
        <property type="protein sequence ID" value="KER18030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178223.1">
        <property type="nucleotide sequence ID" value="XM_009179959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3X3"/>
    <dbReference type="STRING" id="6198.A0A074Z3X3"/>
    <dbReference type="GeneID" id="20330512"/>
    <dbReference type="KEGG" id="ovi:T265_16347"/>
    <dbReference type="CTD" id="20330512"/>
    <dbReference type="OrthoDB" id="6081310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9630" checksum="EBAAAD1DEC806D1A" modified="2014-10-01" version="1" fragment="single">MVSKFAHTGKCNFKTPQSFPLTVQQLGVEDKIRLLHGCCLDLVTLRATHSFSLSAQAQGIVNESSNGERIPFNGNVADGRADYATSHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z526</accession>
    <name>A0A074Z526_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596914">
        <property type="protein sequence ID" value="KER22181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174079.1">
        <property type="nucleotide sequence ID" value="XM_009175815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z526"/>
    <dbReference type="STRING" id="6198.A0A074Z526"/>
    <dbReference type="GeneID" id="20323833"/>
    <dbReference type="KEGG" id="ovi:T265_09665"/>
    <dbReference type="CTD" id="20323833"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052661">
        <property type="entry name" value="Ras-like_GTPase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350:SF2">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45676" checksum="5F25D51402D7057A" modified="2014-10-01" version="1">MFSLLKASVDLCICVPTILRKISNPRKETRGYKTRAEYLDRDPAARLAGWEQVSTLDDEEVSLRRAQSVFTGANASSNTTQSPPKSIPQAISVVPPTRLQTARKSPHEAEKLSSNQSARICCSAKRGPETHEWVPLKKITDVTAPISAIARIPNGSSYLLNAIPEKDEFSAVECASVLRIPIVGSRHSGKTSLVRQFVHCVDVVNPTPTLTRPEYYDRVITFNDRLFNLRMIDCPSIMGRYPTTSAEEWSHYRGWGLRSASAFVLVFDITSDQSFQYTRHLRDQIVSEHADIPVLLVANKIDKLHITEPNSCATHCSPQSTAPTALTTLAGTDSLSRHTISNLRREVAALVKKQWKGTVLVECSARYNWHVVTVFKELMKLLETKEQSHKPTAARAVQNVLRRNQCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5B4</accession>
    <name>A0A074Z5B4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597028">
        <property type="protein sequence ID" value="KER20712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175542.1">
        <property type="nucleotide sequence ID" value="XM_009177278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5B4"/>
    <dbReference type="GeneID" id="20324972"/>
    <dbReference type="KEGG" id="ovi:T265_10804"/>
    <dbReference type="CTD" id="20324972"/>
    <dbReference type="OrthoDB" id="6256092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="29842" checksum="A8CD0C5AFAFD8ABE" modified="2014-10-01" version="1">MSKSTSQTKIRKRPKRCALGIYHTGAVLLFIGILVAIAGLATPRLFDVYISDLRKPARFLYARIAVGLFSVAPEVKWLSLEQDSLQHGLELTDSQWIGAKYAVISGLLVATASFILHVVLACRSTVLTWRSVVFEICGLLIAVIAVLVGLSLAENEIEYVHDHGDEALKRFLSVNQLLSESEFEQAGSANQDRVIVDAVATNLAEARGNLDGGDFALSLTAPQINFALLIAADFLFLVAFLFVLIYFVRLCEKAIETNKQLRSARTSSLDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5X4</accession>
    <name>A0A074Z5X4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597008">
        <property type="protein sequence ID" value="KER20947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175321.1">
        <property type="nucleotide sequence ID" value="XM_009177057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5X4"/>
    <dbReference type="STRING" id="6198.A0A074Z5X4"/>
    <dbReference type="GeneID" id="20324800"/>
    <dbReference type="KEGG" id="ovi:T265_10632"/>
    <dbReference type="CTD" id="20324800"/>
    <dbReference type="OrthoDB" id="6250658at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="72675" checksum="490F590EC599CBD3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6D5</accession>
    <name>A0A074Z6D5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596884">
        <property type="protein sequence ID" value="KER22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173551.1">
        <property type="nucleotide sequence ID" value="XM_009175287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6D5"/>
    <dbReference type="GeneID" id="20323435"/>
    <dbReference type="KEGG" id="ovi:T265_09262"/>
    <dbReference type="CTD" id="20323435"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="260" mass="28651" checksum="289F928607C64D6F" modified="2014-10-01" version="1">MPACNEIFKGNEKIDRRVPKHIIVAGLCNLTEEGGQMVQVVRGSNPTSASRFPLSRLWQPDSIPALVLPSCGMAARHRKGATAERLRKSNSHWKGVWQNRNSTVPIEKPINTLEEQQSIKNRSAVAPFRCLAVIPSEGCTTAGILPGCPSLDRRSRETEVGFKPRTFWSVASGDPDTRVRGIYGVGIALIPKAKSVLLDWTRVTYALSGGLVQLRLTQIDAVNGVCLSYHRMLPTDGSSETKRGEFYQDLSRLLRSGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z793</accession>
    <name>A0A074Z793_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173284.1">
        <property type="nucleotide sequence ID" value="XM_009175020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z793"/>
    <dbReference type="GeneID" id="20323230"/>
    <dbReference type="KEGG" id="ovi:T265_09051"/>
    <dbReference type="CTD" id="20323230"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="386" mass="41970" checksum="B6279174E7321968" modified="2014-10-01" version="1">MQTILNNLNNSAARFSVCFTPAKRREMLQDGEGSDQNPILVHWSFHTTDKLVYLGWLEMRLLFKSATPGELPLTAGFCGAPFVCQEQSEIHSALRVKNLATACTGCTKSCQCLTTCASEVPVKSGGSISLKESSSCDILSAPSYRAAAGNTRAGILPGCPNPGRGSREAEVGIEPRTFQSRCELITPPTDVGRKGSCGPINSCARWPKWLEREFTDRKVRGSNPTSATRLPLSRLGQPASIPTVVLPSAGTAARHRKGATVERFLSFCAERKRDRLTRSTAVANFQIGLASIRPYSTAFVGYSTCIAHEFRLIVPFPDDLGEEADCYALRIVADISEMAQWLNREFTDRKFRGSNPNTVSRLPTGHGQPGSISTLMLPSGGMEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7E2</accession>
    <name>A0A074Z7E2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596868">
        <property type="protein sequence ID" value="KER23023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173225.1">
        <property type="nucleotide sequence ID" value="XM_009174961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7E2"/>
    <dbReference type="STRING" id="6198.A0A074Z7E2"/>
    <dbReference type="GeneID" id="20323183"/>
    <dbReference type="KEGG" id="ovi:T265_09004"/>
    <dbReference type="CTD" id="20323183"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28544" checksum="E57AF9E997A5CC20" modified="2014-10-01" version="1">MLFMFTIAKKFYSKRKQLKNAGEWAIVTGAAAGIGQAYARELAKDGLNIMFIDIDVAGLSSMATELADNFSVKAITFVCDFIPVTSMQCFQRVACPCGLAEDLVYFLDPLSCGRNLLSSQGAWSQALCTQTVQTFDSFRIYTELGKFNVHSMIILTHIVLPRLLKQNKPGSAIINLKSFTGIIPCPGLSLYGASKALIKHFVKSLIPDIKDSDVIIQAVCPLVVFNSPVRDWRPSFFIPTPNEYVRSAIDMLGVGEITIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W8</accession>
    <name>A0A074Z8W8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597161">
        <property type="protein sequence ID" value="KER19655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176597.1">
        <property type="nucleotide sequence ID" value="XM_009178333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8W8"/>
    <dbReference type="GeneID" id="20325797"/>
    <dbReference type="KEGG" id="ovi:T265_11629"/>
    <dbReference type="CTD" id="20325797"/>
    <dbReference type="OrthoDB" id="75801at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="23095" checksum="2F5D451CF6B94481" modified="2014-10-01" version="1">MHDFVSRDAPQPVGAKAGAYKSGDIHYRMSKKIAQLTKVIYMLNCKKEDVDILVKELQMLHKEEILELQRASEVKLKKYRAFAKESYESNLKQSQLSSNMESLQEKLKMQKEVSHQKQITFCSDTTRSSTNDSVVVKTAGVPLTDLWYGTQPDRCVAGDRRDHTEFNTRCQSADGTAVVSNANGSFVDRFVVSKQNVTSEEHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z935</accession>
    <name>A0A074Z935_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596839">
        <property type="protein sequence ID" value="KER23711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172552.1">
        <property type="nucleotide sequence ID" value="XM_009174288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z935"/>
    <dbReference type="STRING" id="6198.A0A074Z935"/>
    <dbReference type="GeneID" id="20322655"/>
    <dbReference type="KEGG" id="ovi:T265_08476"/>
    <dbReference type="CTD" id="20322655"/>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="107240" checksum="3B16AB6B60C86E8A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9C4</accession>
    <name>A0A074Z9C4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597128">
        <property type="protein sequence ID" value="KER19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176410.1">
        <property type="nucleotide sequence ID" value="XM_009178146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9C4"/>
    <dbReference type="STRING" id="6198.A0A074Z9C4"/>
    <dbReference type="GeneID" id="20325647"/>
    <dbReference type="KEGG" id="ovi:T265_11479"/>
    <dbReference type="CTD" id="20325647"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017213">
        <property type="entry name" value="Peptidase_S54_rhomboid_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037470">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="184"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037470-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="385" mass="43245" checksum="38F7C1E38CF98CC2" modified="2014-10-01" version="1">MSVVRRDTLRRHLDKYDADGIPLAELKSLLADSDLPERQISVLVKAADKDGNQRIAYDEFVRQIMSEDEGVWKRLRIRARVLNRAVLAIDPAAGRRHQQDVMVKSGIDSPDTYNWGEADVDNYVEAYDCRPPPIFIPVITLVEIGVFIYYGLLHAWDSDPYNDVTAASGVPIYSPLIYDPRKRHEAWRFLTYMFIHNGYVHLAFNCLLQLVLGMLLELVHKFWRCGLVYLLGVIAGSLAHSVTDPYVLLAGASGGCYALIGAHLASIIMNWKAMQDKWLDNPINFLSSGVVRLFLILLLAGSDTGLAIYARYKNPLGTRVGFSAHLGGFVAGILLGIPILRNLQVEKWEKVCFWICIVVFACFVMAAILFNGFCIRINYCPASVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9T2</accession>
    <name>A0A074Z9T2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596905">
        <property type="protein sequence ID" value="KER22332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173919.1">
        <property type="nucleotide sequence ID" value="XM_009175655.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z9T2"/>
    <dbReference type="GeneID" id="20323719"/>
    <dbReference type="KEGG" id="ovi:T265_09550"/>
    <dbReference type="CTD" id="20323719"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1664" mass="189416" checksum="CFA3E24F6581E3A5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCZ1</accession>
    <name>A0A074ZCZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596997">
        <property type="protein sequence ID" value="KER21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175188.1">
        <property type="nucleotide sequence ID" value="XM_009176924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCZ1"/>
    <dbReference type="GeneID" id="20324697"/>
    <dbReference type="KEGG" id="ovi:T265_10529"/>
    <dbReference type="CTD" id="20324697"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9610" checksum="56A2CDE14C1CCCCC" modified="2014-10-01" version="1">MQRFSCLETSQTRDSAGFQCCTDFGKTSLVKSVWWNSTRIPLYRSHSDAATAEKPISRKIGQEFRTHGGPASSQDLIGRKSGPNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDB6</accession>
    <name>A0A074ZDB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170956.1">
        <property type="nucleotide sequence ID" value="XM_009172692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDB6"/>
    <dbReference type="GeneID" id="20321406"/>
    <dbReference type="KEGG" id="ovi:T265_07227"/>
    <dbReference type="CTD" id="20321406"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16973" checksum="CDCA22867CB1E42C" modified="2014-10-01" version="1">MNDGDIIVHSAGRLKAESEEERGARWNRHNRTDSVISYWELLQPPSDQGNVSFTRQWDVIPWNYSMTSKAALFQNQPITERVRTGCITRHGTLLNDFKSCPVSESANHRAGQNRLQPAFTQSEADLTWMSAVYHAVGDQRLVVIPPHSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDH5</accession>
    <name>A0A074ZDH5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171007.1">
        <property type="nucleotide sequence ID" value="XM_009172743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDH5"/>
    <dbReference type="GeneID" id="20321444"/>
    <dbReference type="KEGG" id="ovi:T265_07265"/>
    <dbReference type="CTD" id="20321444"/>
    <dbReference type="OrthoDB" id="6275211at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16404" checksum="2A87C1D8129387BD" modified="2014-10-01" version="1">MGSVKARLLAPQCRPYYVLIISVFTAIYLVITGLVVDNRYESKLQGPTSSTMDKTVGAFDILAVILLIVTLVLIFMAIILDQKRKLVNLICFVLLTVTLAITLGTTYSLQANTHTPIPAMPTPFCAIMAAMVAVFLSLMILILPCLEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDZ1</accession>
    <name>A0A074ZDZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170759.1">
        <property type="nucleotide sequence ID" value="XM_009172495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDZ1"/>
    <dbReference type="STRING" id="6198.A0A074ZDZ1"/>
    <dbReference type="GeneID" id="20321245"/>
    <dbReference type="KEGG" id="ovi:T265_07066"/>
    <dbReference type="CTD" id="20321245"/>
    <dbReference type="OrthoDB" id="6063370at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="14110" checksum="FAB02C628216DBF8" modified="2014-10-01" version="1">MWRWTNFAKTGNPNLDDAGRQDFVQWPRFKAQTESDDYELLILDIPTRTERNIHKAGCRFWDDEIPGIIEKGIKKESNGCSHRHQLTVHTVNLILFNAFGYILLANGGVPVVINFSPTPLVLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEC6</accession>
    <name>A0A074ZEC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174678.1">
        <property type="nucleotide sequence ID" value="XM_009176414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEC6"/>
    <dbReference type="STRING" id="6198.A0A074ZEC6"/>
    <dbReference type="GeneID" id="20324303"/>
    <dbReference type="KEGG" id="ovi:T265_10135"/>
    <dbReference type="CTD" id="20324303"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="31556" checksum="858927E27F4C66D4" modified="2014-10-01" version="1">MNGLECFDDNSDFIHEETPGFFGCYILVSLNPTARGRTYIGFTVNPNRRIRQHNGGRIKGGAKSTAGRGPWDMVLIVHGFPNDISALRVRVALYKFLSFFPQFEWAWQNPNLSRRLAHLVSPRRPKESPFDYRFRVLSVMLSSGPWNRLGLIVRWINQRYFREFDGVCVPPLHMPIVFGPLHPGESKMPRDPLPQLKACGICSVEFSPSASPEEAVPLTCPALCPSGQWHMTCLARHLTARSADNGQESDYLIPLCGSCPACGSADLFWPNLIAQWKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEV0</accession>
    <name>A0A074ZEV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170444.1">
        <property type="nucleotide sequence ID" value="XM_009172180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEV0"/>
    <dbReference type="STRING" id="6198.A0A074ZEV0"/>
    <dbReference type="GeneID" id="20328305"/>
    <dbReference type="KEGG" id="ovi:T265_14139"/>
    <dbReference type="CTD" id="20328305"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59227" checksum="6257E6FBF86CD2E7" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFB1</accession>
    <name>A0A074ZFB1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171950.1">
        <property type="nucleotide sequence ID" value="XM_009173686.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZFB1"/>
    <dbReference type="GeneID" id="20322184"/>
    <dbReference type="KEGG" id="ovi:T265_08005"/>
    <dbReference type="CTD" id="20322184"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012957">
        <property type="entry name" value="CHD_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009462">
        <property type="entry name" value="CHD_II_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08074">
        <property type="entry name" value="CHDCT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06461">
        <property type="entry name" value="CHDII_SANT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01146">
        <property type="entry name" value="DUF1086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="526"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="827"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1223"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1818"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1818"/>
            <end position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1881" mass="212079" checksum="C783636F7F7E4A98" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFF7</accession>
    <name>A0A074ZFF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Folate receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER21970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174288.1">
        <property type="nucleotide sequence ID" value="XM_009176024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFF7"/>
    <dbReference type="STRING" id="6198.A0A074ZFF7"/>
    <dbReference type="GeneID" id="20324006"/>
    <dbReference type="KEGG" id="ovi:T265_09838"/>
    <dbReference type="CTD" id="20324006"/>
    <dbReference type="OrthoDB" id="567542at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF14">
        <property type="entry name" value="FOLATE RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705145" description="Folate receptor-like domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="265" mass="30579" checksum="229D5642E8DD851D" modified="2014-10-01" version="1">MPLGNTMVAHSLLTVLLIMAANAYDNRLNEIRSVDDYLNICMNGTHHKKAPSPEPTDDHICTDWASMSCCEHKTMRSVQESLLYNFNHSHCKPMSPKCMDMFKRELCFYECSPHVGPWLVKTRSRRRMERSYHVPLCEEDCNMWYEACKIEETCVRDWSVEFEWSKGMNVCPSTSACELFSDVYKNASDFCHAIWDGGWKVEKAPRCMHFVAVDERSKEHNQRVARQAAEEIIRRLSGTSSAYSQFSGLVFLLSSTIPLVFGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGF9</accession>
    <name>A0A074ZGF9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171526.1">
        <property type="nucleotide sequence ID" value="XM_009173262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGF9"/>
    <dbReference type="GeneID" id="20321862"/>
    <dbReference type="KEGG" id="ovi:T265_07683"/>
    <dbReference type="CTD" id="20321862"/>
    <dbReference type="OrthoDB" id="10581076at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="13215" checksum="8653D634E55C6888" modified="2014-10-01" version="1">MEVIPEPVRHVNRPPEKREPLYFATGMELEPPIVNADTSLLVYCYEPNVGKYSTTNKPSLRTTMLPNNALMMSSRLVMKRLQSNCPAQRTSQRPSALPKIPTFSFWGFKNRWKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGI0</accession>
    <name>A0A074ZGI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171482.1">
        <property type="nucleotide sequence ID" value="XM_009173218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGI0"/>
    <dbReference type="GeneID" id="20321824"/>
    <dbReference type="KEGG" id="ovi:T265_07645"/>
    <dbReference type="CTD" id="20321824"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="366" mass="41229" checksum="4E38EDF6E582AF5D" modified="2014-10-01" version="1">MPSTQQNSLETKYFTYSSGYLCNYSLFVIIIIIDSMMSVFNTDASLPYNHDLFESLIVKKRIRVNEGWPPLCLPHSELGMENSDPLSYTGECPRDTHRVSHTRGLTNTISWPSRLGVGTCGDLLRRNGNAFAFPTKHRCLAVRLLTQSLWLRTLIVLLSRCGCPGSIPALNSLKLSIKLTSPSEGSGKPVTALKVKTHSFQWTWRFRLIQRAPCNPDFNSRHRQGCAFLRSTIEKKIRFHRIPNPVLTNQNAPICLGGGEMDQARGSNPTSGSRLPLSRLGQPGIIPALVLPSWQLGTERVLQPNDLFWMQVAENFSTVHDRFWPSWGSSDRRSSRVPVSLIFYLNPTCTKSERYSRLIGDSTEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH00</accession>
    <name>A0A074ZH00_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596894">
        <property type="protein sequence ID" value="KER22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173725.1">
        <property type="nucleotide sequence ID" value="XM_009175461.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZH00"/>
    <dbReference type="GeneID" id="20323579"/>
    <dbReference type="KEGG" id="ovi:T265_09410"/>
    <dbReference type="CTD" id="20323579"/>
    <dbReference type="OrthoDB" id="6262327at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="8">
        <location>
            <begin position="382"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="678" mass="74614" checksum="5E7B65609BBFE3C3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI87</accession>
    <name>A0A074ZI87_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169562.1">
        <property type="nucleotide sequence ID" value="XM_009171298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI87"/>
    <dbReference type="STRING" id="6198.A0A074ZI87"/>
    <dbReference type="GeneID" id="20320294"/>
    <dbReference type="KEGG" id="ovi:T265_06112"/>
    <dbReference type="CTD" id="20320294"/>
    <dbReference type="OrthoDB" id="6243387at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="190"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="785" mass="85346" checksum="18C6CDC4AEDCE6A9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIV2</accession>
    <name>A0A074ZIV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596857">
        <property type="protein sequence ID" value="KER23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172973.1">
        <property type="nucleotide sequence ID" value="XM_009174709.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20322981"/>
    <dbReference type="KEGG" id="ovi:T265_08802"/>
    <dbReference type="CTD" id="20322981"/>
    <dbReference type="OrthoDB" id="6251695at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="409" mass="46374" checksum="25A7C60DD48279C2" modified="2014-10-01" version="1">MKTISFLDTSLLPTHFGYPAHFGPHCFLPEAEFRIVWRFLRCNRCSFRHLYHKLLLDENVRAGFAASHGPANNAQPLHSLTRAIKTILHGFALNKHLPSRLVIASSGSGAPHPISPDAYFTTVLQASFRFQRKFVVCPSHGRELFSFLYFEDDSDSVSSVELDSSLRTKIVPRGHSHFFQSCALHANDQTTDENDSKHVAFTPIRVFAVAAKGVLTTTLETHTYCNITPNTWCNPIPNESVLFSEKTCLSRLEEINHKWNLAYQSTEVEGQMVFAAANSNRFVRFPAPNVVSKVHNLITYATALRLERRNRIWELEAQHRLFDRYRRLLSEGHDPSAATELSQTFTEDEEEEITNCRTAITRNADXVRSSGTKSTNCIERNNCGSWTPVDPEPVTFTYQSTGTQMKMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIY3</accession>
    <name>A0A074ZIY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172962.1">
        <property type="nucleotide sequence ID" value="XM_009174698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIY3"/>
    <dbReference type="STRING" id="6198.A0A074ZIY3"/>
    <dbReference type="GeneID" id="20328837"/>
    <dbReference type="KEGG" id="ovi:T265_14671"/>
    <dbReference type="CTD" id="20328837"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER23300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10445" checksum="D1F5E619AA2BA6B8" modified="2014-10-01" version="1" fragment="single">MSHKQTPRDFLKLIIGRPVVVKLNSGADYRGVLISLDGYMNVVLEQTEEYVDGQLKNKYGDTFIRGNNGLFVILPALNNARILVFYISTQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIY9</accession>
    <name>A0A074ZIY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170549.1">
        <property type="nucleotide sequence ID" value="XM_009172285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIY9"/>
    <dbReference type="GeneID" id="20321076"/>
    <dbReference type="KEGG" id="ovi:T265_06897"/>
    <dbReference type="CTD" id="20321076"/>
    <dbReference type="OrthoDB" id="75950at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="60967" checksum="1880B9D99ED00801" modified="2014-10-01" version="1">MMKDAGCASKHIREFQGSQPGLIGLRERGPTKGTQNPWELTRKREEVRLVALDDLARLEAEQKRIKWEEETRRRMIDDETLRRFKQIKQQQTVEQARKSELLRKTLEEEETALLKQLPAVRDEISERRAKNRAKAKQQEEERRRAERITNSNFALSKQKTLENGRDLQVQLIMKEQERIWKKQEEDLFNQILMKQQLEKDAKLSTDQVKTREANKKLADELQQESRRKEEQKKAIREMNLREEQVELEKIKQQLDDERITGLREKFFRQCKIERNLKECMEERQAAQFLERLREESSAKGILISRDDTDESRALEKERVKKETLQYLDYVHQAKISEKLFENKVEQAAQHALKREAQRVAARKAQEEASRRRLAWETAYVCQQQTQFKEQQRQLEKLMKKHEAEELKTLNDAVQKELSEQITRKRNRIEAYKKELEQQIAGHEIRKAMELAEAERQIEAQNRAEQVLQERIDQAIHSRILDPHRHPWRKMCCQDDATRETPDQTLCGCVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJN9</accession>
    <name>A0A074ZJN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169066.1">
        <property type="nucleotide sequence ID" value="XM_009170802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJN9"/>
    <dbReference type="STRING" id="6198.A0A074ZJN9"/>
    <dbReference type="GeneID" id="20319911"/>
    <dbReference type="KEGG" id="ovi:T265_05729"/>
    <dbReference type="CTD" id="20319911"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="28686" checksum="FF5C71D7CA7D09AF" modified="2014-10-01" version="1">MFFASVVQLNFLEDSDSIEENVGSSGSVDGDRWLVREQANDHHSDSSYCWDLSSTNRNWFRAEHCGESINSPKNEYNFQDAWRALTSPSFPLLQQNERFGRNASDFRLYTHLQTNLVLRETHVELSRTSRLRCFQTTECAAPRRLMFQSLRYSRNRDTFLELIQLSTYVQRCTTSSVSPWMANGVSGDCVSRRMTLHFVGEKCMLRHWMTLEDDIVYIFQIDKVFVHCHMKTRVLKTFRRSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI3</accession>
    <name>A0A074ZKI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172368.1">
        <property type="nucleotide sequence ID" value="XM_009174104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI3"/>
    <dbReference type="STRING" id="6198.A0A074ZKI3"/>
    <dbReference type="GeneID" id="20322515"/>
    <dbReference type="KEGG" id="ovi:T265_08336"/>
    <dbReference type="CTD" id="20322515"/>
    <dbReference type="OrthoDB" id="26722at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53717" checksum="964370BA9C7D69DC" modified="2014-10-01" version="1">MLTQLRTIASPFQSDNLGPIYLGILNTKELLSRPTLGDNRSTNTLPARSFPADTNTIFAGPNWEKSELTFTNNLSFGFSMTSADLRDRSMQLVQVQGFSSILRDVRREHTAIKKKYKYLSKSISFLLKLIHPNVIRTFGIWSEDSSRMSLPSLVSEWPNQGPLDEYLKKNFNSSLVLLDDQLRCKLQVVVYCEPLHMHSSNGTTYVPPEFKHFDESEKELNRNESPIFATLLLNNQYVPNEINNSTKCELSPSPTQPPSLPKESHCVSLTQLHLILCERLTPKSMCDLECKQHGSSCTFNAGNTFVRMKAEDILAFGRIQIELLLAHLILKDEPLLNDCAIVSASPSPFVPCKLRSHGELQQVGTAPVVDSNGYFYNLQHPEDSRQVYEHPVPIFFMKPVHSNPLTTSNHVTLWNLHDFGAFCTLLREAYPTLDLETMLQQCYPKCPCWKVNIDQVSNVCRTIFSELKESSPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL35</accession>
    <name>A0A074ZL35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168493.1">
        <property type="nucleotide sequence ID" value="XM_009170229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL35"/>
    <dbReference type="GeneID" id="20319442"/>
    <dbReference type="KEGG" id="ovi:T265_05260"/>
    <dbReference type="CTD" id="20319442"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="416" mass="47235" checksum="AF8661D9E0DA7391" modified="2014-10-01" version="1">MENPTTNLPFNPREYLEACEKLTQESGAEDRMVCTLLSVVGWICAYILPIICGTGLVGSTMIIIIIVSKPRHLTRPLIYLICMLISGWVSNILIGWIRLFPSRGLPYATNGTIYFYVRHISPLSCTATSMVSNWFFALYSNVLIVASLDRFMAIFYPVRTMHLRNRHAWMAVGTASLFTTLTILPTSSSITWVSLGSQRACWYRKDRTASLVIEQLFSYILPPFVIVTLNVLFYGRIRIMYGKRGKLGKHSTEFQQLRASLTLFLLSTCYVVFTMPGTVFIFDSLVNIGKEEQRGHIIQISRGTVYLLWAVFFLRELANNCVIIIQVPVVRSVVQRKFLSLHKYVAKNSLTAHDLFRPPLGSSSRRSPRVSVNPIFYLKSNCTKLAKYTHLQTILVFARDSLGFQLNLPFVMIPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL46</accession>
    <name>A0A074ZL46_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER26512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169739.1">
        <property type="nucleotide sequence ID" value="XM_009171475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL46"/>
    <dbReference type="STRING" id="6198.A0A074ZL46"/>
    <dbReference type="GeneID" id="20328143"/>
    <dbReference type="KEGG" id="ovi:T265_13976"/>
    <dbReference type="CTD" id="20328143"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1105" mass="122770" checksum="23EBF372A3283A0D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU2</accession>
    <name>A0A074ZLU2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167895.1">
        <property type="nucleotide sequence ID" value="XM_009169631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU2"/>
    <dbReference type="STRING" id="6198.A0A074ZLU2"/>
    <dbReference type="GeneID" id="20318975"/>
    <dbReference type="KEGG" id="ovi:T265_04793"/>
    <dbReference type="CTD" id="20318975"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="437" mass="46704" checksum="044A82DCE93B7700" modified="2014-10-01" version="1">MANVQTSFPLMTKEAAEKTARSIFVGNIPYEATEEKLIELFGKAGPVIGFRLVYDRESGKPKGYGFCEYNNPAIAASALRNLQNIEFNGRPLRIGPAAGEQNSAELALSNPAVGPPLESPYGDKCDPQAAPEAISRAVASLPPEQMYELMKQMKLCIQNNPNEARNMLLQNPQLAYALLQAQIVMKIVDPKVAIAMLNRSHDQIPPAMPDEGETRQKPNAPTSSPAPMPMNNAAPAVAQMMTPHTAPVSIPGMPPTSYSSHPGTIPMGGSHPGAYPMEQHPSAVPVQNTRISQFYPGGGMAPPGGGFPPASNIQPPVQHQQPPPPMPYDYPGNAPQQPRPGMPNPPMNFHPNAPSQMQAAPRPIRPQGPQPITPAIAAAAAANMGPNSILAGQGEQEKVALIMQVLQLSDEQLAMLPEDQRRSIMILKEQLGKTGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMB7</accession>
    <name>A0A074ZMB7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_05904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169303.1">
        <property type="nucleotide sequence ID" value="XM_009171039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMB7"/>
    <dbReference type="STRING" id="6198.A0A074ZMB7"/>
    <dbReference type="GeneID" id="20320086"/>
    <dbReference type="KEGG" id="ovi:T265_05904"/>
    <dbReference type="CTD" id="20320086"/>
    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704155" description="Serpin domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="30038" checksum="D97CFA218E2990A1" modified="2014-10-01" version="1">MDQDYLACPLGVLFLLSSIVGSRAVGGQTGVELVRALRLRSPIADNSLQLAMYESKLLHRELVDDLVAEQSVVNRKRLGIITVSNGMFLRDDYRMRSDFLRSIQNDFQVTVQQNTRFSFIVVLPTERWERTWIDRMLTGQYNIRDLVAAQQPEVVSLKMPKFRMQQTSDLTSALKSMGVISVFQKGEADFSGMTDTNNVHIGMVKQGAVMSVNEIGVDPAGVTASISGASTRLEPTVEFIVDQPFVCMIYDEQLKLPVFTARVIRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP39</accession>
    <name>A0A074ZP39_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167339.1">
        <property type="nucleotide sequence ID" value="XM_009169075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP39"/>
    <dbReference type="STRING" id="6198.A0A074ZP39"/>
    <dbReference type="GeneID" id="20318536"/>
    <dbReference type="KEGG" id="ovi:T265_04354"/>
    <dbReference type="CTD" id="20318536"/>
    <dbReference type="OrthoDB" id="10392651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="21021" checksum="9822E708CBA976C2" modified="2014-10-01" version="1">MFFDGNTVSKGDDDDAHSSLKCPCLCLGNLSVSQPSCLVRMAWHLGTERVYRLKDYYITNSIQTQTKAVSYRNTHIFKQIWFCERLNCNPAESLVCDVSEQLNVLHQTASCFSPYDIRDMAIHVAENSSTAHDQFRPSWDSSGRRSPRVSVNLMFYLKSNCTKLAKYTHLQTNLIFRGTHLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPG7</accession>
    <name>A0A074ZPG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin/FtsZ family, GTPase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168562.1">
        <property type="nucleotide sequence ID" value="XM_009170298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPG7"/>
    <dbReference type="STRING" id="6198.A0A074ZPG7"/>
    <dbReference type="GeneID" id="20319497"/>
    <dbReference type="KEGG" id="ovi:T265_05315"/>
    <dbReference type="CTD" id="20319497"/>
    <dbReference type="OrthoDB" id="6234632at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="9">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="904"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="111157" checksum="F301E3618CCF2E00" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPK1</accession>
    <name>A0A074ZPK1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14251</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171032.1">
        <property type="nucleotide sequence ID" value="XM_009172768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPK1"/>
    <dbReference type="STRING" id="6198.A0A074ZPK1"/>
    <dbReference type="GeneID" id="20328417"/>
    <dbReference type="KEGG" id="ovi:T265_14251"/>
    <dbReference type="CTD" id="20328417"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="155"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="354"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER25245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="61763" checksum="C8F7BFE573746703" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPS8</accession>
    <name>A0A074ZPS8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596714">
        <property type="protein sequence ID" value="KER27817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168455.1">
        <property type="nucleotide sequence ID" value="XM_009170191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPS8"/>
    <dbReference type="STRING" id="6198.A0A074ZPS8"/>
    <dbReference type="GeneID" id="20319418"/>
    <dbReference type="KEGG" id="ovi:T265_05236"/>
    <dbReference type="CTD" id="20319418"/>
    <dbReference type="OrthoDB" id="7758825at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="26185" checksum="D7E629689504B03D" modified="2014-10-01" version="1">MLSSDMLLTHYDPKLPITVVADASNCGVVAVILHAFPDGSEKAIMHASKSLASAEQRYGQIEKEALALGQHRLPETLVSDNGSQFLSSCFQEFCRENTIPHVRSPPHNPQYNGQAERFVDTFKRALLKSRGEGTPFEALQRFLLVYRTTPNESVEDRKSPTEALMGRKLRTTNSAMCPAPMARSRPEVNTNPNQFQIGGSVFVYLDRHKNQLSLRHLLEPPASQSDLPLDILLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQG5</accession>
    <name>A0A074ZQG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nocturnin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166895.1">
        <property type="nucleotide sequence ID" value="XM_009168631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQG5"/>
    <dbReference type="STRING" id="6198.A0A074ZQG5"/>
    <dbReference type="GeneID" id="20318199"/>
    <dbReference type="KEGG" id="ovi:T265_04013"/>
    <dbReference type="CTD" id="20318199"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="335" mass="38322" checksum="79C186937E504F66" modified="2014-10-01" version="1">MTSENPAFNGYERDYCPLLPNVDSMSVAKLRFMQWNVLAHAFATVDQFIHCPTKFLPLENRCEQIVAEIFRFDPDLICLQEVDFLSRLLNRLNANSDKYAAAFSPKVQSPCLKIEDNIGPDGAAIIYRSDRLIALKTMELPLDNLHERSALLCRFQFDSSTKFPSFYVVSVHLKAKLSYVETRLEQGKFLRDGLVKLLSEHGNSDQRSPLFVCGDFNAQPHEPVIELMQQNVFSMTLGWNLTSAYAMANNGKEPDYTTWKIRHSSDEEQPTEIFHTIDYIFYSRDCVYLCGLWWPPLRETIGPTALPSSLFPSDHMNLVADFALPVLDNTEIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH9</accession>
    <name>A0A074ZRH9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166610.1">
        <property type="nucleotide sequence ID" value="XM_009168346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH9"/>
    <dbReference type="GeneID" id="20327489"/>
    <dbReference type="KEGG" id="ovi:T265_13322"/>
    <dbReference type="CTD" id="20327489"/>
    <dbReference type="OrthoDB" id="6265061at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704290" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22666" checksum="9E3B6CD001210048" modified="2014-10-01" version="1">MWWQCRSVISQNMNLFLIGILCPFRSSVHFGSEEDAPVDHILIILSDNKSDNPKRIRSGKPSVKGEDLVDQAGETYLFIDITADGTATPQQIDTSHGPFADFRDNISMEFQMKLIEQLLVDSLSLYQRSKKLAEEKEVHKIVVGHELMETADKLKLRAISLLRRLSKSIVQRDAQNNVRFSDALEKQHLAVLDQIEDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSL7</accession>
    <name>A0A074ZSL7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596691">
        <property type="protein sequence ID" value="KER28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167436.1">
        <property type="nucleotide sequence ID" value="XM_009169172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSL7"/>
    <dbReference type="GeneID" id="20318609"/>
    <dbReference type="KEGG" id="ovi:T265_04427"/>
    <dbReference type="CTD" id="20318609"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="404" mass="45259" checksum="D31A824FFA9BD0A5" modified="2014-10-01" version="1">MFGAQLHRDTDTSALRPCNKWEPDVSTYTAAYSYLTISDEHLFLDPLEACGLNFDVAVSLLYELYGVIQTLMYLYLCEVEVFTDIEYADDIAILDEPIELAGKFVYPGGCTSPGSLAKDDISIRSGKTRAAFVTLHHPRRASYTRLSAEDRVYNTAVRSILLHGLETWPLHAGDVKNLSLIDLRSLSESGGNKSLRWNESGRPDNNLGASSESPYQQNQLCLSLPSPWMGTSGWNTSMFRDIVRHGPIAPSMALCIHAVHSSLPNPPTNRPLTVLYLRTNLSALASNAQLPSPPPKIIGLRNRGSYNRCTLSCLHTDNNKNARLQWIALWYGFCRIQLHSVFFEIKFLADRVLFTAHEKIDLESFLSIGQLVVQRHFLAESEHLLSSRVEAERRCQTGAQKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSX6</accession>
    <name>A0A074ZSX6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166065.1">
        <property type="nucleotide sequence ID" value="XM_009167801.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSX6"/>
    <dbReference type="GeneID" id="20317527"/>
    <dbReference type="KEGG" id="ovi:T265_03340"/>
    <dbReference type="CTD" id="20317527"/>
    <dbReference type="OrthoDB" id="8931646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039165">
        <property type="entry name" value="CREBRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552">
        <property type="entry name" value="ADULT RETINA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552:SF2">
        <property type="entry name" value="CREB3 REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="90661" checksum="FFC7644FFC348720" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTD0</accession>
    <name>A0A074ZTD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Class II Aldolase and Adducin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165648.1">
        <property type="nucleotide sequence ID" value="XM_009167384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTD0"/>
    <dbReference type="STRING" id="6198.A0A074ZTD0"/>
    <dbReference type="GeneID" id="20317193"/>
    <dbReference type="KEGG" id="ovi:T265_03005"/>
    <dbReference type="CTD" id="20317193"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="4">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="5">
        <location>
            <begin position="152"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="969"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="704"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115014" checksum="20FF64513709F84B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTT3</accession>
    <name>A0A074ZTT3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167075.1">
        <property type="nucleotide sequence ID" value="XM_009168811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTT3"/>
    <dbReference type="STRING" id="6198.A0A074ZTT3"/>
    <dbReference type="GeneID" id="20327593"/>
    <dbReference type="KEGG" id="ovi:T265_13426"/>
    <dbReference type="CTD" id="20327593"/>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="979" mass="111468" checksum="A2F135EFBBCADAD3" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW3</accession>
    <name>A0A074ZTW3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167003.1">
        <property type="nucleotide sequence ID" value="XM_009168739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW3"/>
    <dbReference type="GeneID" id="20318279"/>
    <dbReference type="KEGG" id="ovi:T265_04093"/>
    <dbReference type="CTD" id="20318279"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11764" checksum="FBE2141579E40224" modified="2014-10-01" version="1">MLYKRTQARKKYPTNCALMKSPRMVTKRLQAHCQVWRTDQQPPDQQPIHGQRGLHIITGEHRRRMNNRRKYTKRLSRTSNALDKGHRMDLENGEVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVN9</accession>
    <name>A0A074ZVN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165143.1">
        <property type="nucleotide sequence ID" value="XM_009166879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVN9"/>
    <dbReference type="GeneID" id="20316788"/>
    <dbReference type="KEGG" id="ovi:T265_02600"/>
    <dbReference type="CTD" id="20316788"/>
    <dbReference type="OrthoDB" id="6279852at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22846" checksum="878FFFA97310E2ED" modified="2014-10-01" version="1">MEQNSRWAMRNDFPLSEGLPKNSHIYGPSKSDFHVPTIDLSHFENYQTAIRTERLGRCKTVDHGLPFIVFAGIHSSTFFAVSSARFRMSVDLYIDRFIPELAKALSTETKDPRITVDLLVQAIILPFFQKRRSTSCLPRGKLMVDFTSAHRGFFTQPTAMYGERNSHPEKRTSEEFTGHTHVETLSPTPLRLLNRMSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWD9</accession>
    <name>A0A074ZWD9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597190">
        <property type="protein sequence ID" value="KER19519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176739.1">
        <property type="nucleotide sequence ID" value="XM_009178475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWD9"/>
    <dbReference type="STRING" id="6198.A0A074ZWD9"/>
    <dbReference type="GeneID" id="20329683"/>
    <dbReference type="KEGG" id="ovi:T265_15518"/>
    <dbReference type="CTD" id="20329683"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38264" checksum="A701C35FB7494C3F" modified="2014-10-01" version="1">MDWLMGKARGVSKGLVNTNSSTLPVVSDSVVQSSPTSPGTVAILSGNVEGDVKGVSPTSCEPFIPNGSRSVSPVCSPTAPAFVSTSATSSGSIFGQRSLILGKGPSSSKSAPTSPETGASDCPLFMQEKYVMQQLTGSNPSKYVDFRDLVEPFPAMDQNEWLAAHTIALFDNMSTVFDAVHELCTCSQLLPDTMSFVSASVWSNAIDSNSVASPDEDKSKKSKHSGTVVNNSPGPARQQIHSALSSCQELIQSARIFPVRQGEPFPPDLPNYVTLICKNLLLCIMHLYFAHFHHLEQLELVSHLNTLARHFFEFTTRFSLVEDRHLGPLSSFYRVLLDSNPTLIQAPVTPASNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWP9</accession>
    <name>A0A074ZWP9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165985.1">
        <property type="nucleotide sequence ID" value="XM_009167721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWP9"/>
    <dbReference type="GeneID" id="20327371"/>
    <dbReference type="KEGG" id="ovi:T265_13204"/>
    <dbReference type="CTD" id="20327371"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705545" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21685" checksum="48484A3A2A477340" modified="2014-10-01" version="1" fragment="single">FNIRSWLLFVTYEALVLSTVAEEKTKQELSGVYNTRGGIAENKNVQILSGLVNEILTKTLYISRYMSRFLLLKAMLLSDLQKLKEQISGYLSGIISTIDGQISLVDDNKTEAKVVAALFVLDTLKKVDEYLKQQLPHLEEKLVDLNKKLKAANESALEALRGQLSSVLMQVKDEVENKLKKLRGMTYCMINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXV6</accession>
    <name>A0A074ZXV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164024.1">
        <property type="nucleotide sequence ID" value="XM_009165760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXV6"/>
    <dbReference type="STRING" id="6198.A0A074ZXV6"/>
    <dbReference type="GeneID" id="20315882"/>
    <dbReference type="KEGG" id="ovi:T265_01694"/>
    <dbReference type="CTD" id="20315882"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="17593" checksum="B3EC5A8394D58500" modified="2014-10-01" version="1">MATRVFFDITADGSQLGRIIFELYADVPKTVENFRALCTGEMGYGYKGSKFHRIIPQFMCQGGDFTAGNGTGGKSIYGNKFDDENFKHKHTKPGLLSMANAGPNTNGSQFFITTVPCSWLDDKHVVFGEVKEGMDVVKKMEALGSSSGKTSKTVVIADCGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY67</accession>
    <name>A0A074ZY67_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597090">
        <property type="protein sequence ID" value="KER20119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176140.1">
        <property type="nucleotide sequence ID" value="XM_009177876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY67"/>
    <dbReference type="GeneID" id="20325434"/>
    <dbReference type="KEGG" id="ovi:T265_11266"/>
    <dbReference type="CTD" id="20325434"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7550" checksum="FF6EA96FB06D3D8D" modified="2014-10-01" version="1">MIVKPEADQNDSYFCLNSAARGGTGDMQIYVILVHRSVYGGISGYLDDDSQDSLRVAFQMENTSRITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYH6</accession>
    <name>A0A074ZYH6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167854.1">
        <property type="nucleotide sequence ID" value="XM_009169590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYH6"/>
    <dbReference type="STRING" id="6198.A0A074ZYH6"/>
    <dbReference type="GeneID" id="20318947"/>
    <dbReference type="KEGG" id="ovi:T265_04765"/>
    <dbReference type="CTD" id="20318947"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="175"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="835" mass="92611" checksum="424E1C1C89EABAC2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYK5</accession>
    <name>A0A074ZYK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163755.1">
        <property type="nucleotide sequence ID" value="XM_009165491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYK5"/>
    <dbReference type="STRING" id="6198.A0A074ZYK5"/>
    <dbReference type="GeneID" id="20326959"/>
    <dbReference type="KEGG" id="ovi:T265_12791"/>
    <dbReference type="CTD" id="20326959"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="648" mass="71449" checksum="9381C1CE68DC0FD1" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ52</accession>
    <name>A0A074ZZ52_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167679.1">
        <property type="nucleotide sequence ID" value="XM_009169415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ52"/>
    <dbReference type="GeneID" id="20318815"/>
    <dbReference type="KEGG" id="ovi:T265_04633"/>
    <dbReference type="CTD" id="20318815"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9251" checksum="21523ED20C9043E6" modified="2014-10-01" version="1">MRATELHTDPALTLAVRCCYVREAHPTQEWPKSPRVTCLFGIKPRSDWPKVRTQQPITTHYAPNGVCQWRIQNASEFSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZW6</accession>
    <name>A0A074ZZW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163298.1">
        <property type="nucleotide sequence ID" value="XM_009165034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZW6"/>
    <dbReference type="GeneID" id="20315279"/>
    <dbReference type="KEGG" id="ovi:T265_01091"/>
    <dbReference type="CTD" id="20315279"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8666" checksum="FD8BF97D2470A7BC" modified="2014-10-01" version="1">MPEQDDDRSDESGWGPRDPHCAWLKTLQDMAANRCQWCSCCQFLSRLPEGSEASVLNTDVILPMMMMMMMMMMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A041</accession>
    <name>A0A075A041_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597022">
        <property type="protein sequence ID" value="KER20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175474.1">
        <property type="nucleotide sequence ID" value="XM_009177210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A041"/>
    <dbReference type="GeneID" id="20324913"/>
    <dbReference type="KEGG" id="ovi:T265_10745"/>
    <dbReference type="CTD" id="20324913"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="12234" checksum="A46CBBC16FD1577A" modified="2014-10-01" version="1">MVHTKRFSSSERTYSSGIFFPHFWYELCGPPLPRRLPMLILERSSKQYCTCSYASPCDCKSTTRKLGQKRPLCASLKTAKQSKWSKYFFHGLAWTYNPIILSIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0M9</accession>
    <name>A0A075A0M9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164441.1">
        <property type="nucleotide sequence ID" value="XM_009166177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0M9"/>
    <dbReference type="STRING" id="6198.A0A075A0M9"/>
    <dbReference type="GeneID" id="20316217"/>
    <dbReference type="KEGG" id="ovi:T265_02029"/>
    <dbReference type="CTD" id="20316217"/>
    <dbReference type="OrthoDB" id="6274522at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27737" checksum="AEF9D53934CC25B9" modified="2014-10-01" version="1">MATEALQELLKDYDLEQNGFLDKTEWIKLCAQDGINLSPDLASALFDGLDTDADGQVQIGDIVKELSNSETAMEFPQTPLLSDRRSLSFDQSHQGNESPSAVPLNQANRPRESRRKMKRNYQQKDHSRFLSQSSGAHSDNNGGLFTTKKELAEDGSEVFCTTPVPIHPRYKNLMELETEISRSYPKLLPSFNNVIEDFRTEIISSRQEQSSLEQNYLRQPNMLHQAASCFSRYDIRDIVIHVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A110</accession>
    <name>A0A075A110_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164272.1">
        <property type="nucleotide sequence ID" value="XM_009166008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A110"/>
    <dbReference type="GeneID" id="20316070"/>
    <dbReference type="KEGG" id="ovi:T265_01882"/>
    <dbReference type="CTD" id="20316070"/>
    <dbReference type="OrthoDB" id="6265342at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="859" mass="95829" checksum="F27D80A30B81EABB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1E4</accession>
    <name>A0A075A1E4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162752.1">
        <property type="nucleotide sequence ID" value="XM_009164488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1E4"/>
    <dbReference type="STRING" id="6198.A0A075A1E4"/>
    <dbReference type="GeneID" id="20314848"/>
    <dbReference type="KEGG" id="ovi:T265_00660"/>
    <dbReference type="CTD" id="20314848"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="41"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="512" mass="54892" checksum="9DB4D1106153667A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1X1</accession>
    <name>A0A075A1X1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162800.1">
        <property type="nucleotide sequence ID" value="XM_009164536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1X1"/>
    <dbReference type="GeneID" id="20314875"/>
    <dbReference type="KEGG" id="ovi:T265_00687"/>
    <dbReference type="CTD" id="20314875"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="9758" checksum="9ACC4D214401D4C2" modified="2014-10-01" version="1">MIKVLLHASDPSQTTAIDMMDMVNQGPRPPATLTAADNTPHQVASSLGATDYKRNWSESKSKTSKRDFLVTSSIAGTINTPGGKRKRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2E6</accession>
    <name>A0A075A2E6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166597.1">
        <property type="nucleotide sequence ID" value="XM_009168333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2E6"/>
    <dbReference type="GeneID" id="20317967"/>
    <dbReference type="KEGG" id="ovi:T265_03780"/>
    <dbReference type="CTD" id="20317967"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="236" mass="26644" checksum="1211DE8CC2B0345F" modified="2014-10-01" version="1">MAESELLAQSPSFRQPYALLETITYVYLVPRLPPVLSSSNDIHRRFPVACLFYSRVKSSGRLSCMDLGAIVTFDVVGVDPGSARPEAVLSVQRTELFPSLMPPHALVDTILEISRYMDRRNTLLIRLLKILRQPTTSFAHLGAHQVRGSNPTSASQLLLSRLERPGSIPALVQPLGGMAFRHRKAFNNYIHLKINFVFTRDPTKSLVYDILQLNVLHTGHLMFQLARYSRYRSIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U0</accession>
    <name>A0A075A2U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166374.1">
        <property type="nucleotide sequence ID" value="XM_009168110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2U0"/>
    <dbReference type="STRING" id="6198.A0A075A2U0"/>
    <dbReference type="GeneID" id="20317778"/>
    <dbReference type="KEGG" id="ovi:T265_03591"/>
    <dbReference type="CTD" id="20317778"/>
    <dbReference type="OrthoDB" id="6273320at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="331" mass="34290" checksum="2709881C24816006" modified="2014-10-01" version="1">MLQRKSSRRCSAQYYLSAEDHVENEVKHERLLTETSRLSSSWASLSVSGNDKAESDCSSSSVSANNSPNHRPNSFSGPLVISVTCSGNSCQSAHGCHPAQPSSSRCTPTSPTPHSLSSGHASPAASPVSSRVQCYSPGLAPSLSSPTTRRPNTASPLLLPSALCRKRGYFSTMLTAGCSSGDASREGSPDSSLSSGRGCKSMRQADGRAYSFCDAPQFRWPPGPPVTSNPPSPSCHLFPSLLPTGTAPSSPSTSSLPSPRLSFTSSLITFPGSPASSAALNSTTSSGGVPQLLPSPKSETKLTSVMDTEATTSVPPTDDSDRNESASASEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A300</accession>
    <name>A0A075A300_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163576.1">
        <property type="nucleotide sequence ID" value="XM_009165312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A300"/>
    <dbReference type="GeneID" id="20315494"/>
    <dbReference type="KEGG" id="ovi:T265_01306"/>
    <dbReference type="CTD" id="20315494"/>
    <dbReference type="OrthoDB" id="10469510at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="21187" checksum="64CAF4C188B85983" modified="2014-10-01" version="1">MRFTVHSRFLIDEFTFGFEQPFLIHSSTRQPLFVFWNNLHIHPLAQLTGVHSLASDELQTRCFFPLFIPDSASVTYKNKPMKGLRPINDRQRKWMPLPEVLRTNTPEQTVVIDKVGILFLPGSSISEPVLNTMLRAAARYYATLTGKPVSTEEDEFQTTIEHCPEGQSSLENYGFQITKRRPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3N2</accession>
    <name>A0A075A3N2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162137.1">
        <property type="nucleotide sequence ID" value="XM_009163873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3N2"/>
    <dbReference type="STRING" id="6198.A0A075A3N2"/>
    <dbReference type="GeneID" id="20326625"/>
    <dbReference type="KEGG" id="ovi:T265_12457"/>
    <dbReference type="CTD" id="20326625"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704491" description="Peptidase M14 domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="125"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="415" mass="47903" checksum="E9499350F531F6BE" modified="2014-10-01" version="1">MRCFVAALCTLVLHILCVNALYEGYRLVRIFPRGENETKAIQVLEHLGSPHYDIWSIDRRMDRPVCMMVSPEGWNNLSRILDRFNMTCEVLIENLKTEIDHQAREKTRQLRLQMFRTKVKSEHDTYRTVEEIEAAVDRYARKHPFVQIEVLGYTAESRPVRAMKISKDTSKPIIWIDAGIHAREWIAPAATLYFVDRLLTRGGQAFLKDFQFFIVPLVNPDGYHYTHQADRLWRKNRSPTAGEHCVGVDLNRNFPLKWGYGDGTSPRACDDIYRGDGPASELESQALINKLTELKDQIVLYLNLHSFGQFILTPYGFARYRYPGNYNNMINLGELVQKEIQKRYNYVYRVGSASDLLYEASGGAEDFVAGVLNVPYAYTIELCDEGRYGFLLPPAYIRTVGRQLWTAVKVFAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A423</accession>
    <name>A0A075A423_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162095.1">
        <property type="nucleotide sequence ID" value="XM_009163831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A423"/>
    <dbReference type="STRING" id="6198.A0A075A423"/>
    <dbReference type="GeneID" id="20326583"/>
    <dbReference type="KEGG" id="ovi:T265_12415"/>
    <dbReference type="CTD" id="20326583"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057616">
        <property type="entry name" value="PH_2_platyhelminthes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF21">
        <property type="entry name" value="CYSTS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25407">
        <property type="entry name" value="PH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="75"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="815"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116913" checksum="7DF9BDE722CBFBF6" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A434</accession>
    <name>A0A075A434_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174126.1">
        <property type="nucleotide sequence ID" value="XM_009175862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A434"/>
    <dbReference type="GeneID" id="20323874"/>
    <dbReference type="KEGG" id="ovi:T265_09706"/>
    <dbReference type="CTD" id="20323874"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19687" checksum="661E1D35870598FE" modified="2014-10-01" version="1">MRIRFICCRLWEKTLGNGRLVSSGLLCLLITHWIVVLTLPKTVFMKLWVPFRPGDMGVKCLAVLPPEKSTRAGDTARLSKPRHGGSRGRCRIRTTDLPVSKFMLLSLSHLVWQSLVTRATETVQQGMICYTLSVPSCHATRRKHEGWDIVRLRKLVRGSRGRRLNLPVNKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A496</accession>
    <name>A0A075A496_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161952.1">
        <property type="nucleotide sequence ID" value="XM_009163688.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A496"/>
    <dbReference type="GeneID" id="20314219"/>
    <dbReference type="KEGG" id="ovi:T265_00031"/>
    <dbReference type="CTD" id="20314219"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031053">
        <property type="entry name" value="ALC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47157:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="47"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="410"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="709"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1393" mass="157411" checksum="C2A8B74B79A3A743" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4B4</accession>
    <name>A0A075A4B4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4201 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163186.1">
        <property type="nucleotide sequence ID" value="XM_009164922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4B4"/>
    <dbReference type="GeneID" id="20315195"/>
    <dbReference type="KEGG" id="ovi:T265_01007"/>
    <dbReference type="CTD" id="20315195"/>
    <dbReference type="OrthoDB" id="10351629at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34979" checksum="711E01348B5B7516" modified="2014-10-01" version="1">MTSRRSLRAVICTVPSKWSQTSHGSANTVTITELLETKRNCEAPDHILLRQQETSDLLTQRHNLRFRSSCTVDKYRRLDARIKCSIINAEREAVITEMQEACRKNEASLSAYKNNLICSLQMNNALLRASMRRTKAEIFRTAKEEKPTKLDFSLAQKDNTAFSERLEELSSTINRTKCIHSKLRFQYRTVKDNLLRQISEKAQLQRKISQKQAIMASVVEAVKKLNTNLREEKLHHQHRQSMRNIYAAPSVNDCIQQIKLSQSIDREIKLCEQRERLSQLIYQQKLNVLTKLCCSMSRKGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4E3</accession>
    <name>A0A075A4E3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_00840</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162999.1">
        <property type="nucleotide sequence ID" value="XM_009164735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4E3"/>
    <dbReference type="STRING" id="6198.A0A075A4E3"/>
    <dbReference type="GeneID" id="20315028"/>
    <dbReference type="KEGG" id="ovi:T265_00840"/>
    <dbReference type="CTD" id="20315028"/>
    <dbReference type="OrthoDB" id="9995605at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="421" mass="48257" checksum="007B2F6EE3B3146E" modified="2014-10-01" version="1">MMKCYFETEHARWPKWLEREFTDRKVLGSNPTSASRLPPSRLGQPGTIPALVQPSGGMARYGVRTTNRVKQSIGYVGSSVWKCSTVVRPTSAIDLSLVTPYPTKNRRKVCFSIYNIFHFRNAGTKRLFEVKPSDFLNARALDTLHFYTMLGLVPCLVLVFLVNVFVGPAELTDIPEGYEPRYWEYHKHPISRFMAKYMSPHPQKVYESFLGQLEDIREQKELIFEDRWLRSSDRAHGDYRGWYFIPANPAGVNRARKELELDQEMGELDRWLRSSDRAHGDYRGWYFIPANPAGVNRARKELELDQEMGELWLEFTDRKVRGSSPTSASRFHLSRLGQSGNMPAPVLPSADMAVRHRKGATAERLLLYLLIRQSVVSAADPLQCLVSERRDSQKGTQQLYSEQASVRAKVTTAPRYLKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Y4</accession>
    <name>A0A075A5Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162671.1">
        <property type="nucleotide sequence ID" value="XM_009164407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5Y4"/>
    <dbReference type="STRING" id="6198.A0A075A5Y4"/>
    <dbReference type="GeneID" id="20326751"/>
    <dbReference type="KEGG" id="ovi:T265_12583"/>
    <dbReference type="CTD" id="20326751"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="71470" checksum="F995F64BFFB71004" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6B2</accession>
    <name>A0A075A6B2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596870">
        <property type="protein sequence ID" value="KER22984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173255.1">
        <property type="nucleotide sequence ID" value="XM_009174991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6B2"/>
    <dbReference type="STRING" id="6198.A0A075A6B2"/>
    <dbReference type="GeneID" id="20323206"/>
    <dbReference type="KEGG" id="ovi:T265_09027"/>
    <dbReference type="CTD" id="20323206"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="876" mass="96256" checksum="D3379C5EAD42D0CF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6E7</accession>
    <name>A0A075A6E7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162381.1">
        <property type="nucleotide sequence ID" value="XM_009164117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6E7"/>
    <dbReference type="STRING" id="6198.A0A075A6E7"/>
    <dbReference type="GeneID" id="20314560"/>
    <dbReference type="KEGG" id="ovi:T265_00372"/>
    <dbReference type="CTD" id="20314560"/>
    <dbReference type="OrthoDB" id="1244179at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18317">
        <property type="entry name" value="BTB_POZ_Kv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="9">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="404" mass="46056" checksum="24CA3F4478E96A14" modified="2014-10-01" version="1">MTDSPEPASISISQAPMDDQTIDTRWRAKNPNLETPHSGTVTSDKSQPQYRDLRRRSSNFHPKRLLRSLSNAFISQPSTNGRSNGYHLERRRRYGVWHPVHYLVSSAQSKLKQHPRPHSCASHQNPTQPVTGGYHGRFFIGHPNGCSAKIVDSAEESSTMQNGSNKTRQTFVETRESDSDSLNQNDSWPSKLGSDERSVTFMNSDLIRCLCILPPDEPVIVRINVSGVQFHVLSTTLQRDPYVYSKFMEDAIWLPDQREYFVERDPEVFRFIHNYLRHGEVHLPCGICGPLLEKELDDWGLPLGLDIQRCCLGPVMNTKFKLESLQQFENKLQAKYVKPNIWIKHASIIASEQANVLTLRRCDSLVRCIERRPSTFMVGQLTRLSGLPSQVALRAPEIFLTAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A784</accession>
    <name>A0A075A784_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172952.1">
        <property type="nucleotide sequence ID" value="XM_009174688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A784"/>
    <dbReference type="STRING" id="6198.A0A075A784"/>
    <dbReference type="GeneID" id="20322967"/>
    <dbReference type="KEGG" id="ovi:T265_08788"/>
    <dbReference type="CTD" id="20322967"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77968" checksum="DEEE9289048A2860" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8M9</accession>
    <name>A0A075A8M9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164225.1">
        <property type="nucleotide sequence ID" value="XM_009165961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8M9"/>
    <dbReference type="STRING" id="6198.A0A075A8M9"/>
    <dbReference type="GeneID" id="20316039"/>
    <dbReference type="KEGG" id="ovi:T265_01851"/>
    <dbReference type="CTD" id="20316039"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="911" mass="103631" checksum="71FA5DAA5FC0F4D6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8P5</accession>
    <name>A0A075A8P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164075.1">
        <property type="nucleotide sequence ID" value="XM_009165811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8P5"/>
    <dbReference type="STRING" id="6198.A0A075A8P5"/>
    <dbReference type="GeneID" id="20315909"/>
    <dbReference type="KEGG" id="ovi:T265_01721"/>
    <dbReference type="CTD" id="20315909"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="266" mass="30232" checksum="233E1D9A0B9BA891" modified="2014-10-01" version="1">MKETTHKVAENSSTVHDRFRPSKGSSYRRSPRVSINLMFYLNPNRSVFKRYTHLKINLIFTRDSTPGHRQTNDSGHTSTGTGRGKPKGHVVIDQSGHRITEQPMELPVGTVSHDRRKLLTRLLKTLRQPTSGLVLLGAHQMDRVLSRMPGSPPVARPRVSCSPQRPLASAPVSGAVKRPDRLSWNGFQPQAKTRFREIHSFANQFGFHERLNGISRISYSTTECAAHRPPHDSFGTIFEISQCIFIKETTYKFAENILRYLEYRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A915</accession>
    <name>A0A075A915_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163960.1">
        <property type="nucleotide sequence ID" value="XM_009165696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A915"/>
    <dbReference type="GeneID" id="20315818"/>
    <dbReference type="KEGG" id="ovi:T265_01630"/>
    <dbReference type="CTD" id="20315818"/>
    <dbReference type="OrthoDB" id="10340646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="27087" checksum="3D5385F8BDDDFB9E" modified="2014-10-01" version="1">MLPTSCHPTKQRYDVTSKTCHSSGLTYTFSYLDGVQTGNVVTDNLVLGGHLIPEFLFVEVLHSTCQSSPGEEYDGLFGMRKPPGDSRTRIFDPTLVKLAVLAGLADKEVFTFQFCGIEYDDQIICELCNCLIDTGTPTTIMPHEAANRILRNSEIKDNGQGLFHVLHEDLPRVKDLKITIGVYVFVLPPKALLIRKPRYNIYGLAHVPHYQEDKCIIGVSVLRSFVSIFDEKDSQMGFAVVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAF4</accession>
    <name>A0A075AAF4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171710.1">
        <property type="nucleotide sequence ID" value="XM_009173446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAF4"/>
    <dbReference type="GeneID" id="20321996"/>
    <dbReference type="KEGG" id="ovi:T265_07817"/>
    <dbReference type="CTD" id="20321996"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12955" checksum="4084E7C001448682" modified="2014-10-01" version="1">MDTCRLTGVIHTQPVIADKRSQFPQFGDNRFVSHEDGFWTRLIFNVDYQFACTSGRKSPETAGPRGCLVRTSTVLIININSMMSGFKTDASLPYNHDLFENPIVKKRIKLDGEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB05</accession>
    <name>A0A075AB05_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171487.1">
        <property type="nucleotide sequence ID" value="XM_009173223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB05"/>
    <dbReference type="STRING" id="6198.A0A075AB05"/>
    <dbReference type="GeneID" id="20321829"/>
    <dbReference type="KEGG" id="ovi:T265_07650"/>
    <dbReference type="CTD" id="20321829"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10360" checksum="14A287D6097681CB" modified="2014-10-01" version="1">MEENKKLAEANQSLETSFLFQRTELGNAYSEVLKAKSRYQELRSKIDAVKAKYAPDTIWALMMTKKCETEEQSKVVGSTFYLTSPLLESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADA3</accession>
    <name>A0A075ADA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spermatogenesis-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPATA6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162229.1">
        <property type="nucleotide sequence ID" value="XM_009163965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADA3"/>
    <dbReference type="STRING" id="6198.A0A075ADA3"/>
    <dbReference type="GeneID" id="20314445"/>
    <dbReference type="KEGG" id="ovi:T265_00257"/>
    <dbReference type="CTD" id="20314445"/>
    <dbReference type="OrthoDB" id="5963614at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042769">
        <property type="entry name" value="SPATA6_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032732">
        <property type="entry name" value="SPATA6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435:SF6">
        <property type="entry name" value="IP09370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16435">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14909">
        <property type="entry name" value="SPATA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 6 N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="316" mass="37216" checksum="6202788F1058115B" modified="2014-10-01" version="1">MPTYKFEAELTLHCVRPALKITNCLQVHSPGTWLANRDKLYVIVDVFNSCRRTRLVEPIFPLLIHEKFVFQKIFYSALSACNVIDRLDDERIRIELRQITDVYCGGTLLAYFETTARELFCPCAHMCTRTVPKNEITLLRTIDFPGISPRLEYSASSEIKYHPHPPYVSCMRSSDLFYQELPYGTCRHDCLTHYSRPLTPNYHRPTVTSALRCRCPDNPERLYTPLESTYREVRSKSPSVRSRTGSHKQKARPSSEKPYDDLYTTRIPVLSHKFTVAPSWDLRDRVIRDAQDRSDRYWNLYRFWQLEADRRRARHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADC9</accession>
    <name>A0A075ADC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596760">
        <property type="protein sequence ID" value="KER25989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170270.1">
        <property type="nucleotide sequence ID" value="XM_009172006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADC9"/>
    <dbReference type="GeneID" id="20320860"/>
    <dbReference type="KEGG" id="ovi:T265_06681"/>
    <dbReference type="CTD" id="20320860"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6634" checksum="CABB6AC19265AF5B" modified="2014-10-01" version="1">MIGTSRQLGVWKCDEASMSEEPPNSAGPGGTYTGGALEKTTAVPGSPINESEDYVSQRTTAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE16</accession>
    <name>A0A075AE16_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via cytoplasmic region) with ILK.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169796.1">
        <property type="nucleotide sequence ID" value="XM_009171532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE16"/>
    <dbReference type="STRING" id="6198.A0A075AE16"/>
    <dbReference type="GeneID" id="20320487"/>
    <dbReference type="KEGG" id="ovi:T265_06305"/>
    <dbReference type="CTD" id="20320487"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="208" mass="24504" checksum="619CF1770B0CB731" modified="2014-10-01" version="1">MVFFYKCELVHPAYIIYMGADKNENEELIRWGWPEDVWFHVDKLSSAHVYLRLREGETLDDVPDAVLKDCAQLVKENSIQGCKLNDVTVVYTMWENLKKTGDMAVGQVGFHSGKAVRKITVEKRIGEVIKRLEKTKEERLNFDYRAEREERDQRIRAKEKAAQTARKKAEREAQKIREAEAERRSYDRLFVESKMRTNEDGYDSDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE83</accession>
    <name>A0A075AE83_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169670.1">
        <property type="nucleotide sequence ID" value="XM_009171406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE83"/>
    <dbReference type="GeneID" id="20320380"/>
    <dbReference type="KEGG" id="ovi:T265_06198"/>
    <dbReference type="CTD" id="20320380"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="264" mass="29737" checksum="060322F20A4D2E87" modified="2014-10-01" version="1">MKNTNVRNTVYRDECCSPCLLQDDVNREVDSVSLGRKGVVGLLVVLYGFQDGVTVCCWVLVVLYGFQDGVTVTPSVLGWSCCKKWALINVSGVRTVSFFPDCLIERLEVGQYDFTPRPPRTTITRSAGSRCSRSGCSPLAFLAWLCLVERSSSQSSPRDHCGTQARPPRQARRIIRRQAKMSVHHSEWSRKPRTGTELHDRSARYSTCRPRSLVIKTDESQEDENTRRLSQLVHATGDRKPPVSETIKDQSEAIISNKKERFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AES8</accession>
    <name>A0A075AES8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein orai-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_05855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169240.1">
        <property type="nucleotide sequence ID" value="XM_009170976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AES8"/>
    <dbReference type="STRING" id="6198.A0A075AES8"/>
    <dbReference type="GeneID" id="20320037"/>
    <dbReference type="KEGG" id="ovi:T265_05855"/>
    <dbReference type="CTD" id="20320037"/>
    <dbReference type="OrthoDB" id="61124at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24993" checksum="6E095CDA2E64AE4B" modified="2014-10-01" version="1">MSSDLASHCSEARVRRATITPQTVANLLHFYLAREKLTAASRVSALLAGFSLVAIIELDTSVGLNAPQILLAVFTTVSCLTIVCLTLSLMISSCIEPHIDCYAGLFSYLPSEEPPHIRFRIIIEVAWVFGTLIGMSLFLAVMLRACWVKFWYNNTISLITSAVVIVPAMILFIAFSAMFNRTLTHYAVEHSKRIIDYLEPRLSLLESGLLTHDTNKEDDEFSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF35</accession>
    <name>A0A075AF35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168967.1">
        <property type="nucleotide sequence ID" value="XM_009170703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF35"/>
    <dbReference type="GeneID" id="20319826"/>
    <dbReference type="KEGG" id="ovi:T265_05644"/>
    <dbReference type="CTD" id="20319826"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="500"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="738" mass="80612" checksum="CA399A451A99C7D3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFM9</accession>
    <name>A0A075AFM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168325.1">
        <property type="nucleotide sequence ID" value="XM_009170061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFM9"/>
    <dbReference type="STRING" id="6198.A0A075AFM9"/>
    <dbReference type="GeneID" id="20319319"/>
    <dbReference type="KEGG" id="ovi:T265_05137"/>
    <dbReference type="CTD" id="20319319"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="348" mass="40072" checksum="9B8AF74E16346F06" modified="2014-10-01" version="1">MNFACEMMDLCRGTQEVEAVISDFLEDGTNIRDPLGRLRLAIQFEEKKFVAHPNCQQYLTTIWYGSETAFLQSWSLIRKIGLSIAATPLLPLLCLIYIMFPTSNLARSMRCPAAKFATHVVSHFSFLILLAAATFRLEENYDEMMDQEMAGIGDTNSVREWVAKSFRPSKSIITHVQIYIVLWVAGLLLADVKHIYFAGFRSYIANSYNILNFCILSMYIGSYTLRIIVDRWVRESDLYFNATMQINYLLKNNDSQLIHKLVRNWTKSGPFDKSYFITACKSAPLLIGMRTHSTNFLFIHTCWLQMFRIVPPSIHSYLSMRRRKTNLSSYGGLGSLQRIKTVNNKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG47</accession>
    <name>A0A075AG47_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167882.1">
        <property type="nucleotide sequence ID" value="XM_009169618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG47"/>
    <dbReference type="GeneID" id="20327763"/>
    <dbReference type="KEGG" id="ovi:T265_13596"/>
    <dbReference type="CTD" id="20327763"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9632" checksum="7CEC5288BA4CB508" modified="2014-10-01" version="1" fragment="single">ITEFGQPLSTYKAYSSFPRIHLSAETARRKTKTLTLSIANTLSVSATEMGIPKLSNDRLTERFALKNSQTSYILRESITALKHDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH92</accession>
    <name>A0A075AH92_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166810.1">
        <property type="nucleotide sequence ID" value="XM_009168546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH92"/>
    <dbReference type="GeneID" id="20318132"/>
    <dbReference type="KEGG" id="ovi:T265_03946"/>
    <dbReference type="CTD" id="20318132"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="490"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1242" mass="137445" checksum="6FAF0B5FCB15529A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUU4</accession>
    <name>A0A074YUU4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600869">
        <property type="protein sequence ID" value="KER18473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177780.1">
        <property type="nucleotide sequence ID" value="XM_009179516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUU4"/>
    <dbReference type="GeneID" id="20330195"/>
    <dbReference type="KEGG" id="ovi:T265_16030"/>
    <dbReference type="CTD" id="20330195"/>
    <dbReference type="OrthoDB" id="6243234at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="252" mass="29429" checksum="55077E90257AFFEF" modified="2014-10-01" version="1" fragment="single">MPYHDYPTNYPDIENDDRERMRIWHNGVWETKKHVIIGFRVKNDTSLIHFKAHDLKTGLVEFECDFGPAVEGECCVDNRDRVTMQVTDACEKRVVATEFTEDHRDVYYISRLPGSSWNTSIINIKVQTPNGTRRYFYAKPETVSPMVCPEILRGGHESDIPGLVVRLSTTEEHSMSYHILETTGVYIAESEWYHITIRTFQRPDDILTGYEVYYDETVDVQNAHRMHDQTTHPADADFTLATERVQLFQDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVZ9</accession>
    <name>A0A074YVZ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597730">
        <property type="protein sequence ID" value="KER18853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177400.1">
        <property type="nucleotide sequence ID" value="XM_009179136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVZ9"/>
    <dbReference type="GeneID" id="20329953"/>
    <dbReference type="KEGG" id="ovi:T265_15788"/>
    <dbReference type="CTD" id="20329953"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12298" checksum="61DF1D32D7F67993" modified="2014-10-01" version="1">MPQPYKPLDTSWQASVIIDLSHHQLWFTLILYPVADAVKRNYVYRQGAIDAGFPNGDTELRRRNVEVLGDTTNKHIVMLLVIGLLSLAKPYPTCVVCAQDNVFLLFLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ72</accession>
    <name>A0A074YZ72_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600361">
        <property type="protein sequence ID" value="KER18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177736.1">
        <property type="nucleotide sequence ID" value="XM_009179472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ72"/>
    <dbReference type="GeneID" id="20330170"/>
    <dbReference type="KEGG" id="ovi:T265_16005"/>
    <dbReference type="CTD" id="20330170"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8522" checksum="900ABC86AB3204E1" modified="2014-10-01" version="1" fragment="single">VSAITRSKEDREYRRLTSRTKYHAARYKATNPAIVKSNMDDFSLQRNKHWDREWSKASFGTVSEFGVQKRGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZE1</accession>
    <name>A0A074YZE1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597101">
        <property type="protein sequence ID" value="KER20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176214.1">
        <property type="nucleotide sequence ID" value="XM_009177950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZE1"/>
    <dbReference type="GeneID" id="20325493"/>
    <dbReference type="KEGG" id="ovi:T265_11325"/>
    <dbReference type="CTD" id="20325493"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="16675" checksum="1A22E164075D0A50" modified="2014-10-01" version="1">MNFFLKLDCTVVAPFRCLVSIPMEGGIRTRIEPCCPSLDKSSRDAEVGLERRTYRSTSWHLSQNLEELLKNNDQQLSYTWILERFLALFNPDTKRCDSSCPTANVIIIIDSMASLFNTDASLSHNHDLFESLVVEKRVKVDGEGISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZG7</accession>
    <name>A0A074YZG7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597097">
        <property type="protein sequence ID" value="KER20073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176179.1">
        <property type="nucleotide sequence ID" value="XM_009177915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZG7"/>
    <dbReference type="GeneID" id="20329565"/>
    <dbReference type="KEGG" id="ovi:T265_15400"/>
    <dbReference type="CTD" id="20329565"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9344" checksum="F9C8202825DB0728" modified="2014-10-01" version="1" fragment="single">AAEESLTARDRFRLGGYQTDFDKYTHLQINLVFTENSIESLVYGILQLNVLHKGLSHVLFIINDRFSWVSDRVIKKMSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZG8</accession>
    <name>A0A074YZG8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599246">
        <property type="protein sequence ID" value="KER18607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177646.1">
        <property type="nucleotide sequence ID" value="XM_009179382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZG8"/>
    <dbReference type="GeneID" id="20330107"/>
    <dbReference type="KEGG" id="ovi:T265_15942"/>
    <dbReference type="CTD" id="20330107"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7376" checksum="B9AE749601B2BCEB" modified="2014-10-01" version="1" fragment="single">CDLLTTGHCVVLIYFCQRRVDDDYSNLVRSHDLVAAEACTDSVGPSSFYLHELSTFPLVLFHKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z052</accession>
    <name>A0A074Z052_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597070">
        <property type="protein sequence ID" value="KER20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175962.1">
        <property type="nucleotide sequence ID" value="XM_009177698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z052"/>
    <dbReference type="STRING" id="6198.A0A074Z052"/>
    <dbReference type="GeneID" id="20329516"/>
    <dbReference type="KEGG" id="ovi:T265_15351"/>
    <dbReference type="CTD" id="20329516"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="67"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="536" mass="59834" checksum="5AFAC50C371CE6B6" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Q6</accession>
    <name>A0A074Z0Q6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_15274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175635.1">
        <property type="nucleotide sequence ID" value="XM_009177371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Q6"/>
    <dbReference type="STRING" id="6198.A0A074Z0Q6"/>
    <dbReference type="GeneID" id="20329439"/>
    <dbReference type="KEGG" id="ovi:T265_15274"/>
    <dbReference type="CTD" id="20329439"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098560">
        <property type="term" value="C:cytoplasmic side of late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF28">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="17627" checksum="203CA6FDCC4E7E22" modified="2014-10-01" version="1" fragment="single">AVSSCIPDDTLPSGWHRDTVSTSRGHPAKLRLYLCPVGFFIWFACVQFLDDGQDSEKPDPTNPMKATNQADIRQENPVTIFSPPFGPQSVLSTCPICRQNVETKVEYTDGSFTWLLCGLLSMFGLVFGCCLLPFFCQCAKDVSHSCPNCGNRLGVYHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z102</accession>
    <name>A0A074Z102_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175555.1">
        <property type="nucleotide sequence ID" value="XM_009177291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z102"/>
    <dbReference type="STRING" id="6198.A0A074Z102"/>
    <dbReference type="GeneID" id="20324982"/>
    <dbReference type="KEGG" id="ovi:T265_10814"/>
    <dbReference type="CTD" id="20324982"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="424" mass="47066" checksum="5F02D9E0EE2F305C" modified="2014-10-01" version="1">MCPTLEGAPVRPYTVYAEERAVFYTRFRAAEAGRWPTLDLVEITKRSVAVGGDRLPRMGWRDPHCAWLETLQDMTAYRRCLNDHLEGCAPQNDRSAIFTFFAVQGHTNTMLFEMTVHFSGLVGIDAESAKREAGLVELDLLKCRLRAAKADVEELRARLEQLSDQRSLVEDMLEHVACGRAAISERISTVSRATSRIGSYMMKLDRAISFRISQLIHQLVEIFGTELGARDPKNTVPPDTMTEDVARPITFVPLSPSHLNLDYPNSATVRQHTTEPITTDHSLSTNQTVNVIANGSGTKSVNPVESDFVLAASKLGVIAQLLRFVAAVFSHPLRHPLDLTEGTSRAKVTDYLAQELVEGEPNFPLYLSRSSLLPAYKHAVSLLNRDLADLRASAGLSTSVEETTTWNLCTFLQHCLSENVCLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3X8</accession>
    <name>A0A074Z3X8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597079">
        <property type="protein sequence ID" value="KER20202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176047.1">
        <property type="nucleotide sequence ID" value="XM_009177783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3X8"/>
    <dbReference type="GeneID" id="20325356"/>
    <dbReference type="KEGG" id="ovi:T265_11188"/>
    <dbReference type="CTD" id="20325356"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="20897" checksum="3C438D6E9848F1AD" modified="2014-10-01" version="1">MNGPRNQSHEILDITTGGRGYCSRRHRVFGGIYLCKFATVLEENNRDKTLRTSPHQLQTAAGLKIFCAKHHSSIMLLSPEWKQSLSTAIDQLSALLNDSQKPNVIILRHNEKHLLYWAVKRFNAYLFTIAIDNDALFLTSSSKITSGAICRYRATVDSFNYTIIHRNAKGCELATINLCGRVQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z499</accession>
    <name>A0A074Z499_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174343.1">
        <property type="nucleotide sequence ID" value="XM_009176079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z499"/>
    <dbReference type="STRING" id="6198.A0A074Z499"/>
    <dbReference type="GeneID" id="20324042"/>
    <dbReference type="KEGG" id="ovi:T265_09874"/>
    <dbReference type="CTD" id="20324042"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="33885" checksum="19B5829231F02F9B" modified="2014-10-01" version="1">MKSGDARVALIGFPSVGKSTLLNSLTSTHSECASYEFTTLTCIPGVIEYNGANIQLLDLPGIIEGASQGKGRGRQVIAVARTADLVIIMLDATKPDIHRTLLERELEAVGIRLNKRKPNIYFKQKKTGGLKITSMVPLTRINEKMTQMILQEYKIFNAEVIFREDCTPDEFIDVVSGNRVYMGCLYVGCPVTPHSPQVYNKIDQISLQEVDRLAREPHSVVVSCNLKLNLDYLLEKLWEHLDLIQVYTKKRGGKSQFLFHMANTSLHRTTGFRRRTYIEERRNGRACGKHVQSQLLNLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4I5</accession>
    <name>A0A074Z4I5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607041">
        <property type="protein sequence ID" value="KER18185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178068.1">
        <property type="nucleotide sequence ID" value="XM_009179804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4I5"/>
    <dbReference type="STRING" id="6198.A0A074Z4I5"/>
    <dbReference type="GeneID" id="20326516"/>
    <dbReference type="KEGG" id="ovi:T265_12348"/>
    <dbReference type="CTD" id="20326516"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8162" checksum="BF8D2BFA5005911F" modified="2014-10-01" version="1" fragment="single">VPVSSISSTSGLEDNDQPWQLRCEDLRKRDGHRKRHGDTSSLWSSGSSYGRNELARVAGSAEASTLSTKQKDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4T5</accession>
    <name>A0A074Z4T5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596921">
        <property type="protein sequence ID" value="KER22073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174178.1">
        <property type="nucleotide sequence ID" value="XM_009175914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4T5"/>
    <dbReference type="GeneID" id="20329112"/>
    <dbReference type="KEGG" id="ovi:T265_14946"/>
    <dbReference type="CTD" id="20329112"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="16308" checksum="63BB2C794A0CAC44" modified="2014-10-01" version="1" fragment="single">HVIYFLIQADVYHAYQVVRKHKVPAKNIITFAYDDIATNPKNPFQGKVFHDYEHEDVYKGMVIDYRGKRRVDPLGRTPDIRSYRTAAHDRVQPSDFGLSVFVTTSAKENEQSFGIFCFDKDIDVCLANEYSYAWVLDSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5R5</accession>
    <name>A0A074Z5R5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599233">
        <property type="protein sequence ID" value="KER18610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177643.1">
        <property type="nucleotide sequence ID" value="XM_009179379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5R5"/>
    <dbReference type="GeneID" id="20326386"/>
    <dbReference type="KEGG" id="ovi:T265_12218"/>
    <dbReference type="CTD" id="20326386"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="10848" checksum="2276F83A294DA36C" modified="2014-10-01" version="1">MLPCALTMPKASANPAFSPDDHGSGSTPCPRPHFEQAPGVSCAHFRPIHRAENSSLLDVPFGDEDEDYQRLSDFSSIMADLRLRPRVPIRSGEMRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z682</accession>
    <name>A0A074Z682_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598171">
        <property type="protein sequence ID" value="KER18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177508.1">
        <property type="nucleotide sequence ID" value="XM_009179244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z682"/>
    <dbReference type="STRING" id="6198.A0A074Z682"/>
    <dbReference type="GeneID" id="20326341"/>
    <dbReference type="KEGG" id="ovi:T265_12173"/>
    <dbReference type="CTD" id="20326341"/>
    <dbReference type="OrthoDB" id="6286998at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17018" checksum="445463F04B6F2728" modified="2014-10-01" version="1">MEQPNGNIKVKRKSTDSFGLVGSDHTEPATPYPAADKRDEIGNEPLASPAAIPDHPSSAQVTRKPALKPKPVFPPLVPPHGGVTKKPMEPSSQVPPAPVPPDHHYPKVSSKAPTSATRRRHGSQRITDTQVYERLKAVVSKGDPYQKYRLVEKVGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7E1</accession>
    <name>A0A074Z7E1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597323">
        <property type="protein sequence ID" value="KER19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177131.1">
        <property type="nucleotide sequence ID" value="XM_009178867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7E1"/>
    <dbReference type="STRING" id="6198.A0A074Z7E1"/>
    <dbReference type="GeneID" id="20329817"/>
    <dbReference type="KEGG" id="ovi:T265_15652"/>
    <dbReference type="CTD" id="20329817"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="234" mass="25727" checksum="64A8BF58E4A88776" modified="2014-10-01" version="1" fragment="single">KQEGDKGGRNNPKQIIQKLPPTEAEKLLVQLVTVLKSQQPGIPNITPAERRALNTLTKVDNIVITKANKGKAAVAMNKSDYLQVKQHPAEDPYRVIDNANITSIMNRNKAEVGKYLRSVMNHIGEGNWYPLYPKSAIQARLYGLPKIHKPDIPVRPIVNGKGSPPHELARFLAGILKPLTGKSSTYIKYSYDFANKVAGVTVEPDDILGSLSSLVIPKQTMKPQLMLAYASKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L0</accession>
    <name>A0A074Z7L0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal acetyltransferase B complex subunit NAA25 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174688.1">
        <property type="nucleotide sequence ID" value="XM_009176424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L0"/>
    <dbReference type="STRING" id="6198.A0A074Z7L0"/>
    <dbReference type="GeneID" id="20324313"/>
    <dbReference type="KEGG" id="ovi:T265_10145"/>
    <dbReference type="CTD" id="20324313"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119415" checksum="4904B3072B38A0DD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L5</accession>
    <name>A0A074Z7L5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in reproduction of the worm. Involved in host-parasite interaction. Delivered into the host cell by means of parasite exosomes. Binds to acidic phospholipid membranes in a calcium-dependent manner in vitro. Causes aggregation of liposomes in the presence of calcium, but not in its absence. Likely to promote membrane fusion. May provide structural integrity within the tegument.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular exosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173085.1">
        <property type="nucleotide sequence ID" value="XM_009174821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L5"/>
    <dbReference type="STRING" id="6198.A0A074Z7L5"/>
    <dbReference type="GeneID" id="20323072"/>
    <dbReference type="KEGG" id="ovi:T265_08893"/>
    <dbReference type="CTD" id="20323072"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF233">
        <property type="entry name" value="ANNEXIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0041">Annexin</keyword>
    <keyword evidence="5 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="39226" checksum="916315D33C8E1938" modified="2014-10-01" version="1">MSCRCYYVGPDGESYNPSLKAPKTFDVEKDCIALREAMKGMGTDENTIIDILGHRNTEQRLKIRDHYKTMYGKDLIEKLKGELTGNFERLVVMLLTDGPTIKAKALYDAMKGAGTKESVIIEILCTASNDEIAEIKQAYENLIFNCIAFLCSSIDSSLEQDVSSDLSGCFKHFVTALLQGKRDEVTDEQFERMKKEGVSSILDMAKVGQDVADIYDAGVGKLGTDESVFIRLLAGRSIWHLQAVSKAYEKTTGHSLMEAIDSETSGDFRDALMLTLCACILRLRAYSDLLACSMAGLGTNDSSLMRIIVTRCEIDLKDISLQFEADQGKSLAQWIKEDTSGDYCKLLLTLLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7R8</accession>
    <name>A0A074Z7R8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597263">
        <property type="protein sequence ID" value="KER19270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176985.1">
        <property type="nucleotide sequence ID" value="XM_009178721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7R8"/>
    <dbReference type="STRING" id="6198.A0A074Z7R8"/>
    <dbReference type="GeneID" id="20329764"/>
    <dbReference type="KEGG" id="ovi:T265_15599"/>
    <dbReference type="CTD" id="20329764"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000151">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000125">
        <property type="entry name" value="Neurogenic locus notch protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="426"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="497"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="550"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="634" mass="68117" checksum="D76CADB10BACDE2D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7S1</accession>
    <name>A0A074Z7S1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597261">
        <property type="protein sequence ID" value="KER19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176979.1">
        <property type="nucleotide sequence ID" value="XM_009178715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7S1"/>
    <dbReference type="STRING" id="6198.A0A074Z7S1"/>
    <dbReference type="GeneID" id="20326066"/>
    <dbReference type="KEGG" id="ovi:T265_11898"/>
    <dbReference type="CTD" id="20326066"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF45">
        <property type="entry name" value="SVOP LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="26554" checksum="3E3494F956A599E4" modified="2014-10-01" version="1">MAKSLGSVKQLFGKRYLVTTLMLPMIWFGAAFGYYGVVLLSAEIFRFRHSCFGAPSTPPEVLNATLLSDDTPPVDTSCCRDMNDDDFVAMLVSSVGEFINVPLMVLVIDCFGRKITMGVWNGLTGLMFFLLYVCMSKEAMTGVLFVVRAFSAGLLSLAYLYTTEVYPTSCRAIAVGSFSSISRVGAIVTPYVAQVMMPEVSQIGALSLYAAVGVLSSILAFSLPIETAGRELPSHAEEIPVEYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8R9</accession>
    <name>A0A074Z8R9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597168">
        <property type="protein sequence ID" value="KER19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176640.1">
        <property type="nucleotide sequence ID" value="XM_009178376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8R9"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325831"/>
    <dbReference type="KEGG" id="ovi:T265_11663"/>
    <dbReference type="CTD" id="20325831"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50280" checksum="2E96A6DE44C3B5A6" modified="2014-10-01" version="1">MRPLADVYHAYHVVRKNNVPAENIITFAYDDIANNPRNPFKGKVFHDYGHEDAYNGVIIDYRGKDVTRDNFVKVLKGDGKLEANKKKVLKRWVGVEVDIFAALADHSWNSSFAGPRLLFSILAINLLYAMELNDTLAYMHSKKTFNKLVLYVEACNSGSMFKDVLPSNMGTDLPASHNSNLPISLTRTQNDLKTRTLEEQYEEVKKSAASTHVMKYGEIAMGRLPVGKFQGHYDLLTHRNDVATAPNAVDRKSSCKAHLLSKSRRLMEATNDEEQETTWRKLRRALQLGHIVKEMYHDIVMDVTTQHMPTLKGLSKKNELMCFKAVFDQFRTHCFTMQQASCIRDAWKHGFINGTIFIRVGQEMIDTNADVSSPESLSRYSKEEISDIPDAQFRTEISTMDRPNTRGGRITAQELTNKTPCDSTGRLATRLIHKKYVQPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z964</accession>
    <name>A0A074Z964_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597141">
        <property type="protein sequence ID" value="KER19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176478.1">
        <property type="nucleotide sequence ID" value="XM_009178214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z964"/>
    <dbReference type="GeneID" id="20325703"/>
    <dbReference type="KEGG" id="ovi:T265_11535"/>
    <dbReference type="CTD" id="20325703"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704008" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11189" checksum="B837B0E2015FAF0F" modified="2014-10-01" version="1">MRYRMLYLLIRQSVVSAADPLQCLVSERKDSQKGTQQLYSEQASGFDKLAFYMDTFCNPHGQVVEKRCLEGQSSLNSSRPVGTWTEHCVGFSLSCLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9L5</accession>
    <name>A0A074Z9L5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="EMBL" id="KER23808.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="RNase_III_sf"/>
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    </evidence>
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            <dbReference type="EMBL" id="KER20115.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A074ZAI6_OPIVI</name>
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        </submittedName>
    </protein>
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        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="21443" checksum="430D0D6CEE5BFFA7" modified="2014-10-01" version="1">MRNSVSIARTPLSIAQWVAEIHKPLHHGGVLIGKSSLLEVTSICQFIARDQYAFQFNLPLQQLSKNSKQTLTEAEILQLRGHDGFSLLEIAVERFNPTVATVAKTLNDLELDNALSILIPFGFGNVAVPQPSYLLLVTRQLGIGRVLQPNEDENNPLVIVHPSLQITYTVAVPFTVRLYQINPSIDSLDIQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAL2</accession>
    <name>A0A074ZAL2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171910.1">
        <property type="nucleotide sequence ID" value="XM_009173646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAL2"/>
    <dbReference type="GeneID" id="20322148"/>
    <dbReference type="KEGG" id="ovi:T265_07969"/>
    <dbReference type="CTD" id="20322148"/>
    <dbReference type="OrthoDB" id="10024116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="358" mass="40762" checksum="1746F0458E030457" modified="2014-10-01" version="1">MKLNQANNFWTHRLITLGSVEKKQHPLDNLGEQIRRITLHKIKTRICACSENLTMLGAECLQIPKHPTAHILLVFMEETTPSFQSSATTIKPNTGLLWAFPNFFAPNGSGTYEHRNHVWKELTTVSVSERFCEKSVTTVSSSTTAYPIAANGRHVDHKTSSLANLACPIWAPQFKEMGMETPKTKEHYRAIASRTRVCCGPSPTSLRQTALVLMSTEIVFGRSPGDTIGRFNSQSPSLGARQSLINAKVIMATNYLQFRSDPVLVEVDIPKFSQMKFYKHRFHQKVFYNRFSCPTSFSVVTRIPRASVHRVMRRHLHLCPYHFTLLQNTTEQDKEQRVTFANWLLDNEEVQQSSPVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAP7</accession>
    <name>A0A074ZAP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172117.1">
        <property type="nucleotide sequence ID" value="XM_009173853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAP7"/>
    <dbReference type="GeneID" id="20322319"/>
    <dbReference type="KEGG" id="ovi:T265_08140"/>
    <dbReference type="CTD" id="20322319"/>
    <dbReference type="OrthoDB" id="10422365at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704010" evidence="2">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="182" mass="20126" checksum="72AD2A97530632CA" modified="2014-10-01" version="1">MSTHFHLVVTTLFVIMSEVRPLTCYVCDKCPDDLKDVGTMDKCPACVVEKFFDVTDLLRTNRLCGECPRNRITVTNNNRTVNDCCYTNLCLGSVSGTNVQKVQPATTSITRTETNTPKHVTVASEKESIPVRPNKTDDLSMESTAKTATQHLENSSSATCHMSAWYLAFSTSLICLLVACFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB40</accession>
    <name>A0A074ZB40_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173492.1">
        <property type="nucleotide sequence ID" value="XM_009175228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB40"/>
    <dbReference type="GeneID" id="20323394"/>
    <dbReference type="KEGG" id="ovi:T265_09215"/>
    <dbReference type="CTD" id="20323394"/>
    <dbReference type="OrthoDB" id="6254539at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="525" mass="60732" checksum="7A22AA7AC1085715" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBC6</accession>
    <name>A0A074ZBC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">39S ribosomal protein L38, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596875">
        <property type="protein sequence ID" value="KER22882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173370.1">
        <property type="nucleotide sequence ID" value="XM_009175106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBC6"/>
    <dbReference type="STRING" id="6198.A0A074ZBC6"/>
    <dbReference type="GeneID" id="20323294"/>
    <dbReference type="KEGG" id="ovi:T265_09115"/>
    <dbReference type="CTD" id="20323294"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF133">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER22882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="465" mass="53746" checksum="37328F4F5DD097A8" modified="2014-10-01" version="1">MRPLLTNRSLPLFLCFRNHWYRRGFLPPDVEPGRYPFPKRQVPSCGRLSFSERMTELNKKPLSLETLEPVDIGLPFRAPLLSSQRFHTKRPDLEPAARKRQLTVPIDSVHSALEDTQAPLRRLSAARHFDIFNALFGPPHFFVPQINFDVYYPYVAADVQPSAGSTASDSTSVVPVFSGNLITPECAMVPPLIDLSTTPTDHLWTLVMSCPDEPIGGDDGSNAANEYLHWVVTNLQVCGEDEPAKGDEIVPYLPPLPYVGTGYHRYVFILYRQDNGRVDFTPMKRGKAVGDLRTQRQFNTLEFYRQYESELTPGGLSFFQSSWDPSVRNYYRTVLDVSEPIFEIEWPSPRVPPQERFPLANSWNKARRHPHGLPLIRERYGVHNDVSFDVYLDRYRDRKELAEELVRERLQIEGNPLDPNEPRRKQMEYPAAVPLPEGMPSWWVRQEMQRRLRRGRWRHLEGHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBI7</accession>
    <name>A0A074ZBI7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597041">
        <property type="protein sequence ID" value="KER20585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175683.1">
        <property type="nucleotide sequence ID" value="XM_009177419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBI7"/>
    <dbReference type="GeneID" id="20325074"/>
    <dbReference type="KEGG" id="ovi:T265_10906"/>
    <dbReference type="CTD" id="20325074"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9823" checksum="5E2DCE13279EC08D" modified="2014-10-01" version="1">MSLTIDMARLGVPIQENGNDQRREGPTDERHRGSDPIQNTKYTQWLNVSGLWLQNELCNIEMQDPTQSTDEYITLSSYSNPEYSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBW7</accession>
    <name>A0A074ZBW7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171648.1">
        <property type="nucleotide sequence ID" value="XM_009173384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBW7"/>
    <dbReference type="GeneID" id="20328545"/>
    <dbReference type="KEGG" id="ovi:T265_14379"/>
    <dbReference type="CTD" id="20328545"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="44943" checksum="C70E47B1921D7594" modified="2014-10-01" version="1" fragment="single">MMHCNVNPGAVLLAGEGKWKLGGLNFMEKVIDTTKASPKFTGYSAKFPKAAQPNLDFIAPEAQMHNSMSPLADMFSLGMVLCAIYNEGHSLIESDFNPTVYAKRISELKIFNEPTVLSYEGLLSLESRSINQKKEFFNRFAKVVPEYDPVLRYKRILPLLLNWYEKSTELSPFVLPSLLTMIHVAENDDFEAYLREPLMKIMTQRKTLQLKLCVLECIERLLPSLSSPGVAQEIVAFLSTVRTTDSSMLSCILAINRHLLSERKFGITCSTIAGKLLPPLLDALTSPLLGLNDFRLLMDVLRFMLDTIDRQRTCELILRERKSQGGSCSNISSSYYLLRKRNMCYITHFQFFSLSCFYSTPTGLGRNLPLISMQKPTVDADFMGSDIDDARFSRTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBZ0</accession>
    <name>A0A074ZBZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597028">
        <property type="protein sequence ID" value="KER20710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175540.1">
        <property type="nucleotide sequence ID" value="XM_009177276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBZ0"/>
    <dbReference type="GeneID" id="20324969"/>
    <dbReference type="KEGG" id="ovi:T265_10801"/>
    <dbReference type="CTD" id="20324969"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22785" checksum="7BE953612CFAA87B" modified="2014-10-01" version="1">MQQKRGIARQMGDRRPPVYSQPNSPVSKTTRAIVMDELDWLQLLKCERFGGERHGRESDFERCCGVIDIFMRSYRRSEIRQFPPIGLSYDPIVNLWNESVEHSHQTTGVNTMQNQRLTSARCVLMSPIITGTAIIQGLKWSGNTILLLTEKEKMIQETTLFTRECKKSARFSSSAVEISAEPETGRYGVKSMGKRSPVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBZ6</accession>
    <name>A0A074ZBZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597027">
        <property type="protein sequence ID" value="KER20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175532.1">
        <property type="nucleotide sequence ID" value="XM_009177268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBZ6"/>
    <dbReference type="GeneID" id="20324964"/>
    <dbReference type="KEGG" id="ovi:T265_10796"/>
    <dbReference type="CTD" id="20324964"/>
    <dbReference type="OrthoDB" id="10435576at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="20249" checksum="544C659A04F4CBB4" modified="2014-10-01" version="1">MLPYVSDSEILALPSEEFNFFKSAESFRICSYIIRKTAQWPNLIHGCEVLKPDKFVQQPPWPQVSLMLIVDKNEYDRLGHTGSAFNLESKFSSFYWYQMAFNLDPKLPTAEILTRMRGVKNDKELAVKKEEDPEFGPDETKPDSSMTHDIGLAIKSANEYFIAAKRKTLFVDNRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCL9</accession>
    <name>A0A074ZCL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597008">
        <property type="protein sequence ID" value="KER20945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175319.1">
        <property type="nucleotide sequence ID" value="XM_009177055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCL9"/>
    <dbReference type="GeneID" id="20324798"/>
    <dbReference type="KEGG" id="ovi:T265_10630"/>
    <dbReference type="CTD" id="20324798"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13119" checksum="5F5DFDFC88D197A2" modified="2014-10-01" version="1">MRQPGVAHSVSWVPGRVTFVASNYDHQRILIRCLQEINQPRAGKIKQKDANRILPGGVPSFGNPNLAFVDVELMSIRLPEPDLCAQEQVVRTLKLTRIAALRYPNYQEDQIPESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCQ7</accession>
    <name>A0A074ZCQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597005">
        <property type="protein sequence ID" value="KER20980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175272.1">
        <property type="nucleotide sequence ID" value="XM_009177008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCQ7"/>
    <dbReference type="GeneID" id="20324759"/>
    <dbReference type="KEGG" id="ovi:T265_10591"/>
    <dbReference type="CTD" id="20324759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10217" checksum="00A30869F9BF8DA3" modified="2014-10-01" version="1">MSNAPLQRIKRTPVEINAQLNSLTALTIAPGTMYNGENYARNLSMASEPWQNCGIKHPHIVRVFSRKSVLSSVKDKTKTLVTDEYESRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCU1</accession>
    <name>A0A074ZCU1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171170.1">
        <property type="nucleotide sequence ID" value="XM_009172906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCU1"/>
    <dbReference type="STRING" id="6198.A0A074ZCU1"/>
    <dbReference type="GeneID" id="20328441"/>
    <dbReference type="KEGG" id="ovi:T265_14275"/>
    <dbReference type="CTD" id="20328441"/>
    <dbReference type="OrthoDB" id="9991441at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="480" mass="52645" checksum="B46183792E5BAB82" modified="2014-10-01" version="1" fragment="single">ENSRCKPPISPSNGTVRFNGTDIGDSAEYTCDAGFVVRGPRNRHCLATLSWSGEDPSCSNQTNTCFSPPYMPNTRTRSRARPEQISMFSLDIDRDDYKSGEVIEIACQPGYKDPERDYVEAACVGSEWKVTKLNCERVHCGPIRDPPHGHVVYKSDRRYQAEALAVCAEGFIADCGPSSGTQDSTIAITCPRLDAPENGGISTYSTEVNSIVKVHCNHGYELIGPEQKQCLPTGKWDGERTICKERDCGPVPTVVNGRVTAEKTTFGGRATLTCDPDTTASSDTDSLHCGLIDNKTSWLPQPIPTCNRHCYLFTVDHGDVVLMHKPNTPSQRFIPITSENYPQLESIGNALTSSDGIILPGSRVRHGAQLNVTCHRGYQLVKTDQPVTTCMDGVWSVRSKCVPASCRTRPPPAPGARVRFYSLKHEAKGRYECFVGHTLRVDETKQIVQPLNAAGSNDDPLGVIRCLHGEWVGIPVFCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD73</accession>
    <name>A0A074ZD73_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171005.1">
        <property type="nucleotide sequence ID" value="XM_009172741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD73"/>
    <dbReference type="GeneID" id="20321442"/>
    <dbReference type="KEGG" id="ovi:T265_07263"/>
    <dbReference type="CTD" id="20321442"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="14687" checksum="36BE3152485A6AAB" modified="2014-10-01" version="1">MDSFIKIRGVDSVGEARQSDDKEEKWSNANQATFWMARSMRNFAMTKQTKERVKLLNTLFESRYTQSARSRLCPDTIVAENVITKQYLASSGAVEDNAYVSRFLQLCIKRDNETVPRNVVVKLWRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDA3</accession>
    <name>A0A074ZDA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L49, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596782">
        <property type="protein sequence ID" value="KER25271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170993.1">
        <property type="nucleotide sequence ID" value="XM_009172729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDA3"/>
    <dbReference type="STRING" id="6198.A0A074ZDA3"/>
    <dbReference type="GeneID" id="20321434"/>
    <dbReference type="KEGG" id="ovi:T265_07255"/>
    <dbReference type="CTD" id="20321434"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000009">
        <property type="entry name" value="39S ribosomal protein L49, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="22064" checksum="8455556FCD6B599A" modified="2014-10-01" version="1">MLSFAFRVQRGILVASHKKYSINVRWWPNLQNPWEEASRSQSSKLQVPKVPFDISKDDFEWVRKVITINDIPLPNENINSATPSGWVPPNPEISKNYSYSVRRSKNHMLPVYYKQKERKKAERSHGTRNLTIIRHIDGDMWALAEDLRQLLQPKCDGGLFLCQVDEATRQIKMEGIFLEEVSSFLLSCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEM0</accession>
    <name>A0A074ZEM0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170545.1">
        <property type="nucleotide sequence ID" value="XM_009172281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEM0"/>
    <dbReference type="GeneID" id="20321072"/>
    <dbReference type="KEGG" id="ovi:T265_06893"/>
    <dbReference type="CTD" id="20321072"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14030" checksum="148E84F9D19642A9" modified="2014-10-01" version="1">MAKSRNRVPIQLALQSDIHILLDGSNEDCLGNPIPSKDSQLKLQKIKCCFEELQPVNVPSPENPSDGITSKHAKGKDNVKLKIGSHLTGTMSVEETVRYGSVTSAVEYLKTSQNPRPVWPGPTAVQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEN1</accession>
    <name>A0A074ZEN1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170485.1">
        <property type="nucleotide sequence ID" value="XM_009172221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEN1"/>
    <dbReference type="STRING" id="6198.A0A074ZEN1"/>
    <dbReference type="GeneID" id="20321018"/>
    <dbReference type="KEGG" id="ovi:T265_06839"/>
    <dbReference type="CTD" id="20321018"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705411" description="Protein phosphatase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="364" mass="40089" checksum="284AAFA0710A9484" modified="2014-10-01" version="1">MSIFLSHLRLLLRPLAQAVGIHNGSSVRGMARLSLLTSVAGYDNKHPNCLTSLPSQWVYGDDACFISRTNTSYVLGVADGVGGWRAYGVDPGRFSRAVMKNCERLVSSGRFRPNQPGLLIAQSYEDVLTSKEPILGSATLCVISLQRNEHRIYTATLGDSGYLVVRRGRIVERSVHQKHTFNTPFQLACPPPVQSRNFYQDRPTQAVQTSMLVEPGDVLVVGTDGLFDNLTETVILQEVGTVKLLDMNALESLHQCARRLVERARQAAFVPDSSSPFANEARRYGINVAGGISGDITVILGLVVIEDQFPTPGCDFQTQAPYIEKAQSHVGDQRTRSVFSRSAVRPLRIRSRSCSERYLHPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF77</accession>
    <name>A0A074ZF77_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170437.1">
        <property type="nucleotide sequence ID" value="XM_009172173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF77"/>
    <dbReference type="STRING" id="6198.A0A074ZF77"/>
    <dbReference type="GeneID" id="20320987"/>
    <dbReference type="KEGG" id="ovi:T265_06808"/>
    <dbReference type="CTD" id="20320987"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="922" mass="97815" checksum="A62B6E11AF8657B0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF92</accession>
    <name>A0A074ZF92_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171954.1">
        <property type="nucleotide sequence ID" value="XM_009173690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF92"/>
    <dbReference type="GeneID" id="20328617"/>
    <dbReference type="KEGG" id="ovi:T265_14451"/>
    <dbReference type="CTD" id="20328617"/>
    <dbReference type="OrthoDB" id="6272556at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49194" checksum="893B62A3850C69D4" modified="2014-10-01" version="1" fragment="single">IEQSHFDRNCHSYTTVTPGENAYFYISRDSCGFDLRDVPPKAFAIQPETDIGSDVTLFANDGDCTRAPRKLQKTTDRYISSSGKMHIHTTGRNTQDSVSQGFGVLAFPGDERRERHMKDAACNVHLNDKSIQVKTEVSGEQEPLLRDCVVRKSLNAADNSLRIILTRDADGDDCRLRINVAPGFRINMNVEFTSQNPNTYMLLFDGTTCLTEAHLLSEKHKVHTGKSAGGEINILTNAAFVIKYGEISASEPTTNHFEQEVCTNSDEEDEEAEINQESTGGSPRVNEFCVHSYTAPRGFKAELSFTSMNVFEGSGDLHNFLDITGGPYCGVESIDRLGQWPHKKVVSRGPKLCVILVTDCCHGEPWSVTGVFKSSYYSNLNGLTHRMSFVHHFCSHGQNMEYVKTLELSVIRPLMHERYLNHLGSCIILPHKKEHPCAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFR5</accession>
    <name>A0A074ZFR5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170190.1">
        <property type="nucleotide sequence ID" value="XM_009171926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFR5"/>
    <dbReference type="GeneID" id="20320792"/>
    <dbReference type="KEGG" id="ovi:T265_06613"/>
    <dbReference type="CTD" id="20320792"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7107" checksum="A1D0F5ABF31074F5" modified="2014-10-01" version="1">MTECETVVGAASGFRLMLTGLEEKSCVGQTVFWQAGYMLQPAQPMEREKFISRGASVVQPPPSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFW3</accession>
    <name>A0A074ZFW3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170119.1">
        <property type="nucleotide sequence ID" value="XM_009171855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFW3"/>
    <dbReference type="GeneID" id="20320738"/>
    <dbReference type="KEGG" id="ovi:T265_06559"/>
    <dbReference type="CTD" id="20320738"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="294" mass="33631" checksum="6288E8EDC4D97302" modified="2014-10-01" version="1">MANVCLFVVVFCPTETKSHDQREINGLHTRANKKKVHDDSDDDDDDDDDDDDDDDDDDDDDDDDDDDVDDDDDDSDDSDDDDDASDDDDDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDHDHDDDGMIRGDYKIFAAIQKRVAKCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHV4</accession>
    <name>A0A074ZHV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170940.1">
        <property type="nucleotide sequence ID" value="XM_009172676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHV4"/>
    <dbReference type="GeneID" id="20321399"/>
    <dbReference type="KEGG" id="ovi:T265_07220"/>
    <dbReference type="CTD" id="20321399"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705260" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7183" checksum="638AAE5C2ACFF054" modified="2014-10-01" version="1">MNVMSDLLLWLRLQLYVMCATLSTQNVNRSVVNDLPTSENKWNLGLQQDGVADLYRGFYTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI48</accession>
    <name>A0A074ZI48_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173301.1">
        <property type="nucleotide sequence ID" value="XM_009175037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI48"/>
    <dbReference type="GeneID" id="20328911"/>
    <dbReference type="KEGG" id="ovi:T265_14745"/>
    <dbReference type="CTD" id="20328911"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14023" checksum="4A73A214D914B907" modified="2014-10-01" version="1" fragment="single">MFDTIVSNWPSTMPAITSVFPASSTMSVEKFQLHVFDEVSARISKVRITLANLRHLLPQKGISLNLKGRVCQATVRAVLLYGFSTADASETWLVFDGVSVLVTRLLENGYLVELQLFQSGKTSSITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIJ6</accession>
    <name>A0A074ZIJ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169125.1">
        <property type="nucleotide sequence ID" value="XM_009170861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIJ6"/>
    <dbReference type="STRING" id="6198.A0A074ZIJ6"/>
    <dbReference type="GeneID" id="20328015"/>
    <dbReference type="KEGG" id="ovi:T265_13848"/>
    <dbReference type="CTD" id="20328015"/>
    <dbReference type="OrthoDB" id="6233422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="516" mass="59337" checksum="430B14E5481D5AE0" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK10</accession>
    <name>A0A074ZK10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Torsin-1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172561.1">
        <property type="nucleotide sequence ID" value="XM_009174297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK10"/>
    <dbReference type="STRING" id="6198.A0A074ZK10"/>
    <dbReference type="GeneID" id="20322662"/>
    <dbReference type="KEGG" id="ovi:T265_08483"/>
    <dbReference type="CTD" id="20322662"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704172" description="Torsin-1A C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="332" mass="37995" checksum="F8BB0BC2CD76F04D" modified="2014-10-01" version="1">MPSTTFLLLVLLSFVTNISAFPFVALVPVSGLLAAFLARDGIECLLRECCSQGVWFNQTGLKHVLTHHLHGQHIVTERVFHHLSAHMLDRNPPKALALSFHGYTGVGKNFVSNLIASHVFKRGTKSRFFHFYDSTIHFAHRQKVHEYKVRLHKELREAVSACPYSVFVFDEMHNMPSGLLDVLAPLLDFHESIDGVDFRRSIFLFLSNAGGNSINRRLYDHLKDGKKREDLLYTDMDRIITKSAFNDDGGLRYSELIQKHLITAMVPFLPLQAEHVRLCIRDVTVQRQVPLTDNLVNFVLDELEWSPENTQLFSVSGCKRVYEKVAFYLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK54</accession>
    <name>A0A074ZK54_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168844.1">
        <property type="nucleotide sequence ID" value="XM_009170580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK54"/>
    <dbReference type="STRING" id="6198.A0A074ZK54"/>
    <dbReference type="GeneID" id="20327967"/>
    <dbReference type="KEGG" id="ovi:T265_13800"/>
    <dbReference type="CTD" id="20327967"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF1">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL SUBUNIT B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="599" mass="67145" checksum="A3BCB04D59584AE6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKJ9</accession>
    <name>A0A074ZKJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">p53 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172378.1">
        <property type="nucleotide sequence ID" value="XM_009174114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKJ9"/>
    <dbReference type="GeneID" id="20322525"/>
    <dbReference type="KEGG" id="ovi:T265_08346"/>
    <dbReference type="CTD" id="20322525"/>
    <dbReference type="OrthoDB" id="6266945at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00870">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="p53 DNA-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="519" mass="58183" checksum="DCA6F102C1507E04" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL66</accession>
    <name>A0A074ZL66_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169724.1">
        <property type="nucleotide sequence ID" value="XM_009171460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL66"/>
    <dbReference type="STRING" id="6198.A0A074ZL66"/>
    <dbReference type="GeneID" id="20320432"/>
    <dbReference type="KEGG" id="ovi:T265_06250"/>
    <dbReference type="CTD" id="20320432"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13634" checksum="64D9F28B61063AC3" modified="2014-10-01" version="1">MSQPTQLLVLDTFFNGSIRCTTGNALSNHLVTDTPTPTHTSYGSEGTIVEHLETFQFRCLNRSSLTVIHTTQQPSLDTHVTSDYGINHSDTIDYYYNDDDDDDDDDRGGGDDGDKSSLSTEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLA1</accession>
    <name>A0A074ZLA1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">SNF-related serine/threonine-protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SNF1-related kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_05206</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168414.1">
        <property type="nucleotide sequence ID" value="XM_009170150.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLA1"/>
    <dbReference type="GeneID" id="20319388"/>
    <dbReference type="KEGG" id="ovi:T265_05206"/>
    <dbReference type="CTD" id="20319388"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14074">
        <property type="entry name" value="STKc_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14339">
        <property type="entry name" value="UBA_SNRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000166">
        <property type="entry name" value="SNF-related serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="184"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="698"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="900"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1139"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1420"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1497"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1424"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1501"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1517"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00077142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KER27851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1574" mass="174473" checksum="CDC1CF3F9FC6C2B3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLH7</accession>
    <name>A0A074ZLH7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168091.1">
        <property type="nucleotide sequence ID" value="XM_009169827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLH7"/>
    <dbReference type="STRING" id="6198.A0A074ZLH7"/>
    <dbReference type="GeneID" id="20327803"/>
    <dbReference type="KEGG" id="ovi:T265_13636"/>
    <dbReference type="CTD" id="20327803"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="725" mass="81843" checksum="F6FBF70588DBE7BC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLW1</accession>
    <name>A0A074ZLW1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596813">
        <property type="protein sequence ID" value="KER24350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171889.1">
        <property type="nucleotide sequence ID" value="XM_009173625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLW1"/>
    <dbReference type="GeneID" id="20322133"/>
    <dbReference type="KEGG" id="ovi:T265_07954"/>
    <dbReference type="CTD" id="20322133"/>
    <dbReference type="OrthoDB" id="10616314at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19905" checksum="A8DC3CB3D92E4423" modified="2014-10-01" version="1">MTSIYTDCPLQPVMDHSRCGRNGCPSNVKRGMKCQTCKVWWHFKRTGLQDDQISRLANSPDPFVCASCLYVKGAMHTAAKRRAPKNALIGILDAKLERLSKALEDSNTKNATKVDKELSSLNEYLAISIPGPLAAEKVIQSFSKNNEWVGFRYKLYKFLIKDGMHTKRLAVCAFMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM11</accession>
    <name>A0A074ZM11_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169434.1">
        <property type="nucleotide sequence ID" value="XM_009171170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM11"/>
    <dbReference type="GeneID" id="20320193"/>
    <dbReference type="KEGG" id="ovi:T265_06011"/>
    <dbReference type="CTD" id="20320193"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13874" checksum="D8FAD788C773585A" modified="2014-10-01" version="1">MKQPQGQYFETEQLCGAACAMTRDKGDHFRRSKIKVRNATPARMKQPQGQYFETEQLCGAACAMTRDKGDNTFPAPHMVHREDVDLLDSKESRSCHVLSFHWAFEPLWTFGIFGGLSKLCDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM53</accession>
    <name>A0A074ZM53_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168108.1">
        <property type="nucleotide sequence ID" value="XM_009169844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM53"/>
    <dbReference type="STRING" id="6198.A0A074ZM53"/>
    <dbReference type="GeneID" id="20319149"/>
    <dbReference type="KEGG" id="ovi:T265_04967"/>
    <dbReference type="CTD" id="20319149"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51699" checksum="4CEE3EC331342ABC" modified="2014-10-01" version="1">MEMMILDELTKVIPSFGMHFAPTKCKVMLVDVQSLNTPLTIQGEVLEVVERFTYLGSCISSDCSVTEEVNARICKDRAAFANLRHLWRQNDRGSRETEVGFERRTFRSVNSRCNHLSHLAPLHSSPDKLWQFFICGCTLPASISCSHECLFRTFPQYPSLDRGSRETEVGFERRTFRSVNSRCNHLSHLAPLHSSPDKLWQFFICGCTLPASISCSHECGKTRKFVPNFETERKRSAVAPFRCLAAMPPEIKHEGWDTARLPKPRQGKSSGGGRIRTTDLPSMMDTDMPNRTRNQFIQFIRYKPCAISTLVPAVTVSVSGNWESVGHTAKHWTHVRLVLELSSYALKTIALMHNAETFHTSGSIQKFQQWKKKQKLRKETTHKVAENSSTAHDRFRPSTSGSSGRRSPRVSVNLMIYLNPNSTVFEKYTHLQINMVFTSVISSGPRSVSPFLGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMJ7</accession>
    <name>A0A074ZMJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169286.1">
        <property type="nucleotide sequence ID" value="XM_009171022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMJ7"/>
    <dbReference type="STRING" id="6198.A0A074ZMJ7"/>
    <dbReference type="GeneID" id="20320075"/>
    <dbReference type="KEGG" id="ovi:T265_05893"/>
    <dbReference type="CTD" id="20320075"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="457" mass="50402" checksum="233C0C4DB8A617DA" modified="2014-10-01" version="1">MHSSFSNPHLAPRGGPLILLDLCTNLSSPACNAQLPTPPQSSVDEIAVVQALYDEYAVITADDYEILGRQGGKPEDVYDSHQSLASRIVKIEHKVDAIDVKIDRLVSLCRTDRSGFHHLGTSNHRRLPAPPDTFSHYLHPKCDDLEDQLQPLNETVDPVLHSAKIPDTQTNLPPGFHPAPLVTRFVVPKEQRSESIDTTVTEYKNPETSSTVCVEEVSPQPEAPSHHVLRQCTSLPPATQPIITASDAVGSQHLVAAHGPSTTRMVRSEHHPGVSQATGETSPSWRSTDCLPRTTATECAAPGRLMFQSLRYLKYRDTCIFVYEAATCCILRRRCLSLINADSRCLGLVQGCDALHIEGALSIWLTSSAPESLGRFWAFCGCFQEADLPDTNHNNSIHLLLVQKIWQKSNSAQGNYLLATRSPLIGRAFFPKFAPDGFRRLQQSSAAQVYTSRSMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMX7</accession>
    <name>A0A074ZMX7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Neurotransmitter-gated ion-channel ligand binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_14364</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171591.1">
        <property type="nucleotide sequence ID" value="XM_009173327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMX7"/>
    <dbReference type="STRING" id="6198.A0A074ZMX7"/>
    <dbReference type="GeneID" id="20328530"/>
    <dbReference type="KEGG" id="ovi:T265_14364"/>
    <dbReference type="CTD" id="20328530"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="270"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="487"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="709"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER24670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="96491" checksum="A44171B7768A05A3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN10</accession>
    <name>A0A074ZN10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169095.1">
        <property type="nucleotide sequence ID" value="XM_009170831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN10"/>
    <dbReference type="STRING" id="6198.A0A074ZN10"/>
    <dbReference type="GeneID" id="20319933"/>
    <dbReference type="KEGG" id="ovi:T265_05751"/>
    <dbReference type="CTD" id="20319933"/>
    <dbReference type="OrthoDB" id="6227366at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="82"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="554" mass="61862" checksum="A839A71EA34BC88C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN84</accession>
    <name>A0A074ZN84_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167407.1">
        <property type="nucleotide sequence ID" value="XM_009169143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN84"/>
    <dbReference type="GeneID" id="20318586"/>
    <dbReference type="KEGG" id="ovi:T265_04404"/>
    <dbReference type="CTD" id="20318586"/>
    <dbReference type="OrthoDB" id="10302026at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="195" mass="21372" checksum="89F0FD2C313B951B" modified="2014-10-01" version="1">MNASSDRKKPPAESQRHSRESRHPHKYRTRPTAKVEPHRISDHREASVRRAPDVPHRGVKYFNWYPASSSTEDNEDTFNLDVRSPTEGDIPQWQDSPSCVRTRVIPEISSVHRDLPLPPLAQPCTAQPKPCTTTLVNESSHPEEFLVNKSIASRHIAAPVPKPGTGARTGDSAVWAGVVALGTSPVVPVGGATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNF8</accession>
    <name>A0A074ZNF8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167627.1">
        <property type="nucleotide sequence ID" value="XM_009169363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNF8"/>
    <dbReference type="STRING" id="6198.A0A074ZNF8"/>
    <dbReference type="GeneID" id="20318770"/>
    <dbReference type="KEGG" id="ovi:T265_04588"/>
    <dbReference type="CTD" id="20318770"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46450" checksum="0A03584E0015740C" modified="2014-10-01" version="1">MGFTPKKRSRRIRGKCKAFPKDRRSLPPHLTAFLGYKAGMTHIVREVDRPGSKVHKREIVEPVTILECPPMVIVGLVGYAPTARGLRTFKTVWAEHLTEECRRRFYKDWCKSKKKAFTKASKKWADEAGLREINRDLKKVKKYCTVVRAIAHTQMRLMKHRQKKAHIMEIQVNGGTVSQKVDWIRQHFEKQIPIMNVFSQDEMIDVIGVTKGKGFKGVTSRWHTKKLPRKTHKGLRKVACIGSWHPARVGSTVARAGQKGYFHRTELNKKIYRIGLGVQAQLEAAKAEAAKEESKDKSALIKPKGNASTDFDLTAKNITPMGGFPHYGEVRNDYVMIKGCCMGPKKRVITLRKTILAQVNRRSKEKIVLKFIDTSSKFGHGRFQTRAEKKAVMGPLKKDHEREKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNV5</accession>
    <name>A0A074ZNV5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171263.1">
        <property type="nucleotide sequence ID" value="XM_009172999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNV5"/>
    <dbReference type="STRING" id="6198.A0A074ZNV5"/>
    <dbReference type="GeneID" id="20328466"/>
    <dbReference type="KEGG" id="ovi:T265_14300"/>
    <dbReference type="CTD" id="20328466"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="502" mass="57061" checksum="86DE56B41006269D" modified="2014-10-01" version="1" fragment="single">MIQVENNQVLLFKINRLPQTSKILGAELHYLHSSCQEIQCNHSDKKGRRSPRYLHFCFHQSVANQPLQLIGSRRIFTRPNRWMVIELNNSVILSSEAQIKFSVTLSPPSKCRMQPVSRQCTQSSFFRQNGAFMVIYLREEHHSIRTLSPPRNAVFNLGSDITGSVHLTTIVPNLNKSNEQVAKRRELQKNSEPVYQQPGNSHALFQRIRANGQKRADINETICEEDGTVIHFVNCRLERPAEPIQDNRWKDQAELNETSTLTRHQKRKTSMIYQPYTTISAQEGYAKSIMLSAQYPSHLRCSSALFCSVPPLQTSDVRRLSESEDYFLFCRSSETVATEGVRSKFISLMRVLYVNHCGRVRVYGKFSPEFTTSSSVRQCCPPSPSPVKFFIDLLHEIPLHCEEGLQNWVGSDPNLMLAEEPIELLEMGLSLESRGPVQPLLISDTYCAHVTSVFCQGGAIHTASWVRNLASMFREHTLSVSVFKALVESGGKIGLVMLRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPN3</accession>
    <name>A0A074ZPN3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170969.1">
        <property type="nucleotide sequence ID" value="XM_009172705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPN3"/>
    <dbReference type="STRING" id="6198.A0A074ZPN3"/>
    <dbReference type="GeneID" id="20328400"/>
    <dbReference type="KEGG" id="ovi:T265_14234"/>
    <dbReference type="CTD" id="20328400"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="240"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="441"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="882" mass="99268" checksum="3B1A722B0A8460B2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX0</accession>
    <name>A0A074ZPX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_13696</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168380.1">
        <property type="nucleotide sequence ID" value="XM_009170116.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZPX0"/>
    <dbReference type="GeneID" id="20327863"/>
    <dbReference type="KEGG" id="ovi:T265_13696"/>
    <dbReference type="CTD" id="20327863"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1561"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1623"/>
            <end position="1978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KER27862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2126" mass="236875" checksum="EBF1C851BB86B05B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQG7</accession>
    <name>A0A074ZQG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168219.1">
        <property type="nucleotide sequence ID" value="XM_009169955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQG7"/>
    <dbReference type="STRING" id="6198.A0A074ZQG7"/>
    <dbReference type="GeneID" id="20327841"/>
    <dbReference type="KEGG" id="ovi:T265_13674"/>
    <dbReference type="CTD" id="20327841"/>
    <dbReference type="OrthoDB" id="5790032at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="27100" checksum="B9B8F2917DFEE583" modified="2014-10-01" version="1" fragment="single">MVLDTGSAVVWVPSITASAIWTKHNLYDPSQSETASLKDSPFRRTYGTKVIKGRIFEDRIKVGELTFESFAFGAADEVVDYPIYEHFDGVLGMAIKSEHEGMRRTFLERLANRKFGLFFRSGEEESIMVVGDEAEKYMPREAYQIPLTSESYWTVKFHWMFVGRVSFNMNGYRAALDTGSIVAELPTHIMEAIDMELKVTGLQGVLHQVDCSKIKELPAIELLGDEVQLKILPSQYILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQI7</accession>
    <name>A0A074ZQI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166832.1">
        <property type="nucleotide sequence ID" value="XM_009168568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQI7"/>
    <dbReference type="GeneID" id="20318147"/>
    <dbReference type="KEGG" id="ovi:T265_03961"/>
    <dbReference type="CTD" id="20318147"/>
    <dbReference type="OrthoDB" id="6156608at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14001" checksum="CFBE47AB400395F7" modified="2014-10-01" version="1">MSIDVDALLSRLSPTMSSSTKAELGSVLSEYTDVFAWKDSDVGRTKQVQHCADTGDATPIRLPPRRVPIQYQHQLNQMIDDMLSKDIIKPSAEPDTPLNPHVFRGSENKPLNLRSCASVWTVGESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS42</accession>
    <name>A0A074ZS42_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165993.1">
        <property type="nucleotide sequence ID" value="XM_009167729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS42"/>
    <dbReference type="GeneID" id="20317470"/>
    <dbReference type="KEGG" id="ovi:T265_03283"/>
    <dbReference type="CTD" id="20317470"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="24202" checksum="A152C721084777FA" modified="2014-10-01" version="1">MDSNFGVEKVVDTTDGLLKKAIHPSSSRSLAISIDSLDDEDLLAAPRVGGLRFRCRPTANLCCIPARSGDTFCADKEPSVSACNGLLTSIEWLELPRARSLVQSSPYNEPKEEYASFRYMKFSEDAGSSALMASGSGIDSLEILYLYSVASMKDCHSRWRLASSAKFSVTLLSLPFKFTLPSNLPTLRVPPSNSSFARIAGLLNPPPTRLFPALATSKCSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU46</accession>
    <name>A0A074ZU46_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598432">
        <property type="protein sequence ID" value="KER18714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177539.1">
        <property type="nucleotide sequence ID" value="XM_009179275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU46"/>
    <dbReference type="GeneID" id="20330037"/>
    <dbReference type="KEGG" id="ovi:T265_15872"/>
    <dbReference type="CTD" id="20330037"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9731" checksum="6C5B8D78F3EBEDF3" modified="2014-10-01" version="1" fragment="single">MASVCRYRSCFIAPNSPGLKPCSNTYLVASCFLLVYTIALELHRPTCLACKTSNEYPKASKLRPREITVPLSTSENATPARKKPQVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUB9</accession>
    <name>A0A074ZUB9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166773.1">
        <property type="nucleotide sequence ID" value="XM_009168509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUB9"/>
    <dbReference type="GeneID" id="20318095"/>
    <dbReference type="KEGG" id="ovi:T265_03908"/>
    <dbReference type="CTD" id="20318095"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="12298" checksum="042AA8002E2854A6" modified="2014-10-01" version="1">MFDLLLFCQSKTTFMCMYTEADSSTPNQENKIPPTDRPRQTMPCHAESTSETECETMFDRSSRHRLHVMLSRNRQKQTWRDEAVVSKVKRYPNENYRLFTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUC1</accession>
    <name>A0A074ZUC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597900">
        <property type="protein sequence ID" value="KER18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177450.1">
        <property type="nucleotide sequence ID" value="XM_009179186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUC1"/>
    <dbReference type="GeneID" id="20326315"/>
    <dbReference type="KEGG" id="ovi:T265_12147"/>
    <dbReference type="CTD" id="20326315"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="16366" checksum="9E86850CB279F8A0" modified="2014-10-01" version="1">MFCPAPIHLSGSPVRPGTAQQSSAGTGVRAQLLPTVGPHLVSHMDGPDKRPVPSLSPYYAAAAAQVRLPCQPGSHVMCWRVCTADCGAAQRDAGRSGTRAGNCTCAAPYGEKIFSTQRPPTGKLALGRKNYPIRAPRTLQLTASIPLRTRTCSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUN4</accession>
    <name>A0A074ZUN4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165366.1">
        <property type="nucleotide sequence ID" value="XM_009167102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUN4"/>
    <dbReference type="GeneID" id="20316965"/>
    <dbReference type="KEGG" id="ovi:T265_02777"/>
    <dbReference type="CTD" id="20316965"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10770" checksum="78499280F79B89EF" modified="2014-10-01" version="1">MCELNWRDDREEDRLRKANIAHSTLMLVSKTDQPYAEPVVESRSGCGQVKTIEESTIYDLAEKYVIPISFVLKPSAYLDQDPETRLIPIVNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUT8</accession>
    <name>A0A074ZUT8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169100.1">
        <property type="nucleotide sequence ID" value="XM_009170836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUT8"/>
    <dbReference type="STRING" id="6198.A0A074ZUT8"/>
    <dbReference type="GeneID" id="20319938"/>
    <dbReference type="KEGG" id="ovi:T265_05756"/>
    <dbReference type="CTD" id="20319938"/>
    <dbReference type="OrthoDB" id="6279429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39323" checksum="5D9B530164A895D6" modified="2014-10-01" version="1">MVVFKIITPSERTQDKTEVTRWAVKDDWCERIWDEFIKLLQRIFNTKSSRFFISWYDGTDYCTVREFADLSQAVEFFTEEGSQDKAIRLFVSPDTTEHKTIFGEKPTEDKEEEEVENDTCVVESYELLETQDIQETEEEQTPEQPTQAEEVEECLARTTLDEGGDSNEVPTQTHMPAPAPVPTPAYPAMPMYPYMYTMNTVGQPIMYPQWPVPPVVPPLAPVPVPAVAPIAEPEQNDQETSTFSGASALPPVPASAQAPVPLPEPAPAPAPAPEPAPAPMPAPTPKPKNDPAYPTKLPVCPGGNKSNSKTSYVRKALVILRQLGFQQDDRTLKKLIKQHKGNLNAIIDALSSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWV0</accession>
    <name>A0A074ZWV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164263.1">
        <property type="nucleotide sequence ID" value="XM_009165999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWV0"/>
    <dbReference type="GeneID" id="20316061"/>
    <dbReference type="KEGG" id="ovi:T265_01873"/>
    <dbReference type="CTD" id="20316061"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8555" checksum="84FD96721EF8E699" modified="2014-10-01" version="1">MRRSRRSRAGGKGTDIHDKTSHVLRKKNIHVDGRVLVSIDGHVFRVWEECGHGLVFVFSMLYDPVFPRTKKHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX27</accession>
    <name>A0A074ZX27_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165765.1">
        <property type="nucleotide sequence ID" value="XM_009167501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX27"/>
    <dbReference type="GeneID" id="20317283"/>
    <dbReference type="KEGG" id="ovi:T265_03096"/>
    <dbReference type="CTD" id="20317283"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="769" mass="81261" checksum="E9D82C203B44D982" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXS7</accession>
    <name>A0A074ZXS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163995.1">
        <property type="nucleotide sequence ID" value="XM_009165731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXS7"/>
    <dbReference type="STRING" id="6198.A0A074ZXS7"/>
    <dbReference type="GeneID" id="20315853"/>
    <dbReference type="KEGG" id="ovi:T265_01665"/>
    <dbReference type="CTD" id="20315853"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="724" mass="80800" checksum="544DA253CBD748F5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZL5</accession>
    <name>A0A074ZZL5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164866.1">
        <property type="nucleotide sequence ID" value="XM_009166602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZL5"/>
    <dbReference type="GeneID" id="20327156"/>
    <dbReference type="KEGG" id="ovi:T265_12988"/>
    <dbReference type="CTD" id="20327156"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9724" checksum="2452C18647BDDA99" modified="2014-10-01" version="1" fragment="single">TFIHAIWTETDKNATDIGWQPYLVVSPTRHSEDHAVPILEAAMPTEEGTRGEIQPGHPSLDRSSQDDEVVFKPRTFWSVSWRLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZZ1</accession>
    <name>A0A074ZZZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164672.1">
        <property type="nucleotide sequence ID" value="XM_009166408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZZ1"/>
    <dbReference type="GeneID" id="20316408"/>
    <dbReference type="KEGG" id="ovi:T265_02220"/>
    <dbReference type="CTD" id="20316408"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="15041" checksum="B62478962C8AD94A" modified="2014-10-01" version="1">MASSPAAVAAATAYQQALMAAGYPPQRYTCAQTTHSGLVPTTAVTVSSAPVSQSTTATEYTNHRGSPNSPSAIGQRMGFSQPNQWADERDVVTADDTTKSTIAAAAATATTATASCDSNECSAKHHNLDALQPSANLDNLFSYIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0P5</accession>
    <name>A0A075A0P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162979.1">
        <property type="nucleotide sequence ID" value="XM_009164715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0P5"/>
    <dbReference type="GeneID" id="20326801"/>
    <dbReference type="KEGG" id="ovi:T265_12633"/>
    <dbReference type="CTD" id="20326801"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17475" checksum="2774263C84801C92" modified="2014-10-01" version="1" fragment="single">MASFASDVLYVRYASETAAAMVVFLLWRIIRIINALMMHKQQQYELRIAMQKRARRLLGRKMEIIRTEKEMQDKHIGALEDLLRELGASAEVIRRCKPRYKKCTKEQTNNALKSIAALTTGVMGGLVGAPSNFQGVISKYGGTAINTPTASQKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0W6</accession>
    <name>A0A075A0W6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163299.1">
        <property type="nucleotide sequence ID" value="XM_009165035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0W6"/>
    <dbReference type="STRING" id="6198.A0A075A0W6"/>
    <dbReference type="GeneID" id="20315280"/>
    <dbReference type="KEGG" id="ovi:T265_01092"/>
    <dbReference type="CTD" id="20315280"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="25840" checksum="22246385357F2F0E" modified="2014-10-01" version="1">MVDTVLNNEGIALHNKLRERHGCGPLSYDSSLARSAQLWAEELATTKCMRHSDMATYGENLAYRCIEGRGPFGADEATKSWYDQSSMYDFGEGFTYETSYFSQLVWKDSKLVGFGRATSSDGTASYIVAHYSPKGNIRDRFHENVPYASRRLTHSSLQELRPPEISSRPVSTLSSKELKEREKQEKKLRERQEKERKELEKRMKKEQKQREKLEKKEKRKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A359</accession>
    <name>A0A075A359_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162500.1">
        <property type="nucleotide sequence ID" value="XM_009164236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A359"/>
    <dbReference type="STRING" id="6198.A0A075A359"/>
    <dbReference type="GeneID" id="20314651"/>
    <dbReference type="KEGG" id="ovi:T265_00463"/>
    <dbReference type="CTD" id="20314651"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12035">
        <property type="entry name" value="SH3_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001592">
        <property type="entry name" value="Peripheral plasma membrane protein CASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="8">
        <location>
            <begin position="359"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="509"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="596"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="725"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="104390" checksum="42AEE8AFED1B4F6C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3D7</accession>
    <name>A0A075A3D7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162116.1">
        <property type="nucleotide sequence ID" value="XM_009163852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3D7"/>
    <dbReference type="STRING" id="6198.A0A075A3D7"/>
    <dbReference type="GeneID" id="20326604"/>
    <dbReference type="KEGG" id="ovi:T265_12436"/>
    <dbReference type="CTD" id="20326604"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47049" checksum="417DD0A0D67439FA" modified="2014-10-01" version="1" fragment="single">IVSILYLWATCHRIPSKPISTIYFLIARLVANCTNISVQMVSVRLVRDRDTDAFKGYAYVDFEDETSFQTALKTDGSIVEGFRLRVNPAQEKRGSRGGPRGGPPRAMGNGYGRGGGGGAYQGRGNQDNWSSRGRPNMGPGGGRFTERGPRGGGGGMGGRGGPQRQSYHPPGLARDPIVNDRPDTGDLNSNSSGEERPRLKLKPRTVPLNQTDDRHLSERSKAIFGTGRPREPSPLREEAPTTSSYMGKRFYCDYCDKSFPDNATNRRAHLNGVQHQQARRLHFDRYLGRCPGVFETTFGTAPQEKLVLERAKKPCIGFARTGAFSACPVIHFTGECNYGVLCKYSHMTPEMLHQLEQQAKEKASDVLRLSYLSSEQNIEALLQKLESVVLKRRMERERFGSTSESHSLVLPVGFENADLPPSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A408</accession>
    <name>A0A075A408_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162240.1">
        <property type="nucleotide sequence ID" value="XM_009163976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A408"/>
    <dbReference type="GeneID" id="20314456"/>
    <dbReference type="KEGG" id="ovi:T265_00268"/>
    <dbReference type="CTD" id="20314456"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16518" checksum="1548AEDE62FC4CC5" modified="2014-10-01" version="1">MFRPVEALSKERTNRTTADIEVKNRFHESAYVVRGLNPTYTSQLTLFRLGQPGSIPAVTLPSGGVTPGYRKGVTAERFFFADCVNEPCLPVTIGMPLPWSPSQKASDKQPERAPNKGRQKLDQQLSKRNWWKLRAKMEVVWCNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A420</accession>
    <name>A0A075A420_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163118.1">
        <property type="nucleotide sequence ID" value="XM_009164854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A420"/>
    <dbReference type="STRING" id="6198.A0A075A420"/>
    <dbReference type="GeneID" id="20315127"/>
    <dbReference type="KEGG" id="ovi:T265_00939"/>
    <dbReference type="CTD" id="20315127"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="67"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="373" mass="41951" checksum="A527796913E0E191" modified="2014-10-01" version="1">MDFVLYPKMLHMGSRHYRINPTRHELSQNLLIPVSQLDENDLTEHPWADTEDTLSNEFTETIEPDNEGFRVKLRIPTLFHGFIIGHRREKLKQLEQEFSCRVIFPPLGSTSSDITVRAASRASVAGACRRLLWIQTNARMRANPTHFICLPANSPELQRNFLSFRQTALDFAARDTCGDFMGLSIDVFKSPASLHFTIIPLLLADSSEVQLACDLMHSFSQSDIGRTVFSDGPFRLTIQGLEYMSDDPEKVKVLYAKIAPSADRDRLQRMSNGLTKLFQEHNLLGGKLHRPDGDVLLHLTLLYASDSSASQSSSSPFNVTGLLRELGNFTFAEDHCFDTLHLCLMGSQTGDEFYSSCCQLNFSDPSNPILTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4E2</accession>
    <name>A0A075A4E2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_00079</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162000.1">
        <property type="nucleotide sequence ID" value="XM_009163736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4E2"/>
    <dbReference type="STRING" id="6198.A0A075A4E2"/>
    <dbReference type="GeneID" id="20314267"/>
    <dbReference type="KEGG" id="ovi:T265_00079"/>
    <dbReference type="CTD" id="20314267"/>
    <dbReference type="OrthoDB" id="9986177at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11722">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057835">
        <property type="entry name" value="EF-hand_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032393">
        <property type="entry name" value="SOAR_STIM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037608">
        <property type="entry name" value="STIM1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15136:SF5">
        <property type="entry name" value="STROMAL INTERACTION MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25578">
        <property type="entry name" value="EF-hand_STIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16533">
        <property type="entry name" value="SOAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="550"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="753" mass="84923" checksum="9D0B95C7E2D1BEC3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5P5</accession>
    <name>A0A075A5P5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactate/malate dehydrogenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596883">
        <property type="protein sequence ID" value="KER22724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173532.1">
        <property type="nucleotide sequence ID" value="XM_009175268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5P5"/>
    <dbReference type="STRING" id="6198.A0A075A5P5"/>
    <dbReference type="GeneID" id="20323422"/>
    <dbReference type="KEGG" id="ovi:T265_09243"/>
    <dbReference type="CTD" id="20323422"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="32347" checksum="7A6F8E3A6339F759" modified="2014-10-01" version="1">MISGAGVSNTTKTAGWLQDGVYCENVPHGSGTKRITSWCRHQALRTPQRHLSGQPSQNAQETTRTKSRLKSLINSKSGRPKGGGETATTLNSSNSKAAEAVLKCLFTNCLSFFNKLDYVKQSACLEQPSRIALTETRFAPDGIPTELVIVDLNVEKVEAEISDLQNARQYLPKVSIYGGSNYKLSANSNIAILCAGVDKRDNENQLSHVQRNVDALKSNLLTTSLIATAVIPHLVENSPKCTIIVLIKPGTSQACMLIRPQLMFWPMWLGESVDFQKTAFLDLGQWLILPDSVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA09</accession>
    <name>A0A075AA09_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171875.1">
        <property type="nucleotide sequence ID" value="XM_009173611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA09"/>
    <dbReference type="STRING" id="6198.A0A075AA09"/>
    <dbReference type="GeneID" id="20322125"/>
    <dbReference type="KEGG" id="ovi:T265_07946"/>
    <dbReference type="CTD" id="20322125"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="19255" checksum="AEDEB74D04390AB2" modified="2014-10-01" version="1">MLNGDNPLMDDRDQVPNDLREAFALFDVNRDGRITASELESVLNFLGMRTTRAEVSQMIKDADCDGNGSVDFEEFLRMMRRYSQRERSKSPDAELREAFNVFDHNQDSVIDFEEIKRTMHFLGEAVTDAEVHEMIREADRDNDGKVDFEEFKYLMRLVRSRDGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAB5</accession>
    <name>A0A075AAB5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CPC1/SPEF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171740.1">
        <property type="nucleotide sequence ID" value="XM_009173476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAB5"/>
    <dbReference type="STRING" id="6198.A0A075AAB5"/>
    <dbReference type="GeneID" id="20328568"/>
    <dbReference type="KEGG" id="ovi:T265_14402"/>
    <dbReference type="CTD" id="20328568"/>
    <dbReference type="OrthoDB" id="6275805at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054517">
        <property type="entry name" value="SPEF2_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22946">
        <property type="entry name" value="SPEF2_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPC1/SPEF2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="578" mass="66073" checksum="54066059F059B318" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB14</accession>
    <name>A0A075AB14_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171503.1">
        <property type="nucleotide sequence ID" value="XM_009173239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB14"/>
    <dbReference type="STRING" id="6198.A0A075AB14"/>
    <dbReference type="GeneID" id="20321845"/>
    <dbReference type="KEGG" id="ovi:T265_07666"/>
    <dbReference type="CTD" id="20321845"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="554" mass="61947" checksum="B04B070E6C7EC69E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABA1</accession>
    <name>A0A075ABA1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163216.1">
        <property type="nucleotide sequence ID" value="XM_009164952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABA1"/>
    <dbReference type="STRING" id="6198.A0A075ABA1"/>
    <dbReference type="GeneID" id="20326857"/>
    <dbReference type="KEGG" id="ovi:T265_12689"/>
    <dbReference type="CTD" id="20326857"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="359"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="659" mass="75955" checksum="5D67CB9AB1293EFE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABZ8</accession>
    <name>A0A075ABZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isy1-like splicing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162824.1">
        <property type="nucleotide sequence ID" value="XM_009164560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABZ8"/>
    <dbReference type="STRING" id="6198.A0A075ABZ8"/>
    <dbReference type="GeneID" id="20314899"/>
    <dbReference type="KEGG" id="ovi:T265_00711"/>
    <dbReference type="CTD" id="20314899"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33604" checksum="53B1BD5D97875DA4" modified="2014-10-01" version="1">MVSPHHLLLILMFRSRRAAQKKQSSLGEYKLRDLNDDINKLVREKGHWEDHIKTLGGPDFKAEAPKMLEKEGKEVPGNRGYRYYGAARDLPGVRELFEEAPIAQKVAEWKARREDPNFRSKVAKRDLPIEDQEEFDEDTADLRNIYAAGDNPADDELMRLYEAIDIDEPAASTDVPTVEQLAALGQNVDEDEEDEYIAMVNGRVSSKTMSSLGNVKRAFVAHVPVFTQEQIEASLLAQRKREILEKYMSSDLIASMAETGEILGMEDGTIETNPDANAVDANDFKGSDVEEEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACA1</accession>
    <name>A0A075ACA1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170936.1">
        <property type="nucleotide sequence ID" value="XM_009172672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACA1"/>
    <dbReference type="STRING" id="6198.A0A075ACA1"/>
    <dbReference type="GeneID" id="20321395"/>
    <dbReference type="KEGG" id="ovi:T265_07216"/>
    <dbReference type="CTD" id="20321395"/>
    <dbReference type="OrthoDB" id="6287439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="418" mass="42961" checksum="63C80354ABE1FE8D" modified="2014-10-01" version="1">MQGTWGKTHLTLGSIGHRVNYTAATQHIAHEQISSASATVSSGCITIASATTGVHGPSVVAHVSSPAPVLSPTNSTVLSPTIAVLCTAPGASSTPSSNVPVGGSGARVRVSGPSTAPNSHRTHPPKAPHTHSLHGQSDQSAHVDVQHHRQHSHGHPPQAHTPANHLGTHNRSCSQPVPMSVGHDGSAATGHLQQATSASSRSGTQPQLSGPILGLSASSSLIGLSVASASCGPLVGQVPHLGSATTNSSSGQLVQGLECLRLNTSTSPASALATSPHMLEAQSSQRQQRGQQQQQQAQTQQQQTQHAQTPYMLPVNALSPSLQGGSIRFASNVVTPTPLSAAQHSHQGSMDSGVGQSLTGQSSASADQTPEHAVMLFCDPRLNECNTEHMEGISYPSEEIGCTPYNVFDNIDISDITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACQ1</accession>
    <name>A0A075ACQ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162450.1">
        <property type="nucleotide sequence ID" value="XM_009164186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACQ1"/>
    <dbReference type="GeneID" id="20314601"/>
    <dbReference type="KEGG" id="ovi:T265_00413"/>
    <dbReference type="CTD" id="20314601"/>
    <dbReference type="OrthoDB" id="6261141at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705653" evidence="1">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="323" mass="35490" checksum="A5958C158807F1D7" modified="2014-10-01" version="1">MTRWCLFSLLIMRELLTLVAVPAVAHLTIPSQTSDVFGLPNTLSSGLLSSQTKGIIPSQWDTQNLFSTLPTVVSDNPVTSVTTLPGNLATNVGLGDGLVQTPILDTTARSSGLLQPNLLTNLPSISTLPSTTTLDTTLPAVSNILTHPRMTDLVTPNNLAIGTLDTPVSTLPVINPLGTAVRSGAIETPGSIQTDSVISPKITVNTVRTINLPNVVDSSTVPLWRPRPRVLIYVVPKVKYIPHKKMKKFVLRKKRLLHKYAEDPTDDLYDGMRRTYYDPYIGWPDDFGGPYGIPPRPPRWKGFGMRRHRLHGRHGPVFPREVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD91</accession>
    <name>A0A075AD91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional adapter 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170326.1">
        <property type="nucleotide sequence ID" value="XM_009172062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD91"/>
    <dbReference type="STRING" id="6198.A0A075AD91"/>
    <dbReference type="GeneID" id="20320904"/>
    <dbReference type="KEGG" id="ovi:T265_06725"/>
    <dbReference type="CTD" id="20320904"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="96542" checksum="3E924F4D0DD9EA2F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEW9</accession>
    <name>A0A075AEW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neuropeptide Y</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPY family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169127.1">
        <property type="nucleotide sequence ID" value="XM_009170863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEW9"/>
    <dbReference type="GeneID" id="20328017"/>
    <dbReference type="KEGG" id="ovi:T265_13850"/>
    <dbReference type="CTD" id="20328017"/>
    <dbReference type="OrthoDB" id="9972427at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001955">
        <property type="entry name" value="Pancreatic_hormone-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020392">
        <property type="entry name" value="Pancreatic_hormone-like_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00159">
        <property type="entry name" value="Hormone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00265">
        <property type="entry name" value="PANCREATIC_HORMONE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50276">
        <property type="entry name" value="PANCREATIC_HORMONE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER27139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14899" checksum="E0099906349694A9" modified="2014-10-01" version="1">MRAYGLALPYRSYTDVTVPGIRIIIRLFVMVLIISSMFNVTRSINENVPFISKKLNSSCSTSSSIWPSFYTLSAVKRILTLSILPTADARAVDSSFPNPPAYFRDQEHMQNYVRALNYYFQVFGRPRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFT3</accession>
    <name>A0A075AFT3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_05041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168205.1">
        <property type="nucleotide sequence ID" value="XM_009169941.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AFT3"/>
    <dbReference type="GeneID" id="20319223"/>
    <dbReference type="KEGG" id="ovi:T265_05041"/>
    <dbReference type="CTD" id="20319223"/>
    <dbReference type="OrthoDB" id="6778822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="13">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="652"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="731"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1585"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1757"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1934"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1585"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1759"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1956"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER28064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2064" mass="228548" checksum="4607061F78030C52" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGL2</accession>
    <name>A0A075AGL2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the jagunal family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167382.1">
        <property type="nucleotide sequence ID" value="XM_009169118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGL2"/>
    <dbReference type="GeneID" id="20318561"/>
    <dbReference type="KEGG" id="ovi:T265_04379"/>
    <dbReference type="CTD" id="20318561"/>
    <dbReference type="OrthoDB" id="8914197at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009787">
        <property type="entry name" value="Jagunal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20955:SF1">
        <property type="entry name" value="PROTEIN JAGUNAL HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07086">
        <property type="entry name" value="Jagunal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21597" checksum="DAB8A5F5F9BB7CD4" modified="2014-10-01" version="1">MTSRAGARPTGTDGTDFRHREKVAMQYNQGPLLKRRIRVVFMLHFALWLLMFVRLFPELCLRFGFKTRSLVEKSNLWEYVWCFGSLVPTVFGYLSLNKNRAGLMRIAVTGTVVFGLGSVVVGCFQNALELLEYYGTRKARHFFYGFPLIVLIYIFFSLCVQVHGFSVYFGYKLYSLWSQHSARKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ6</accession>
    <name>A0A075AIJ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164535.1">
        <property type="nucleotide sequence ID" value="XM_009166271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIJ6"/>
    <dbReference type="STRING" id="6198.A0A075AIJ6"/>
    <dbReference type="GeneID" id="20316300"/>
    <dbReference type="KEGG" id="ovi:T265_02112"/>
    <dbReference type="CTD" id="20316300"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="23762" checksum="56835D6B4C1C994D" modified="2014-10-01" version="1">MFTIRNAGNFVPCGEPPSESICTVLGTLDLACVRGKVNELIVCGHSDCKNEKDLKTSKPRNSARFQAMHLLNSIGPSLVRGELPVSQMSPIEKWVAINGLASYRKHTLTSDVLHFPVVDPQVRKSNFNLKLSSLKDFEECDRLSQVNVVQQMTNFYCQPLLAERLRSGLLNVHGLWFHIQSGQLHMFSRDRQSFVPVTSDTLPDLVKELDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJE0</accession>
    <name>A0A075AJE0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163066.1">
        <property type="nucleotide sequence ID" value="XM_009164802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJE0"/>
    <dbReference type="GeneID" id="20315095"/>
    <dbReference type="KEGG" id="ovi:T265_00907"/>
    <dbReference type="CTD" id="20315095"/>
    <dbReference type="OrthoDB" id="10554438at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="23520" checksum="455055F4D7030424" modified="2014-10-01" version="1">MKAIRELRPPCVQIWLCSVPTVVARRVISKVWRTNRVSNDRIKFIFCSCSHHSRLHDRATVLAYLFWRVHTQEKHWTRVSLLLELVSSTYPMTVPGFEPRRSDMRGECETTTPPTHVGRDACEFSRLNRPTRSHLSDVIRVPNSSNDDPATVLVMTIDLHASQDFPVSVTYPVSPHQGEALNSNSALIRAHQQCISNGRAGIRTPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJP5</accession>
    <name>A0A075AJP5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trypsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162521.1">
        <property type="nucleotide sequence ID" value="XM_009164257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJP5"/>
    <dbReference type="STRING" id="6198.A0A075AJP5"/>
    <dbReference type="GeneID" id="20326701"/>
    <dbReference type="KEGG" id="ovi:T265_12533"/>
    <dbReference type="CTD" id="20326701"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF10">
        <property type="entry name" value="SERINE PROTEASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="221"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52041" checksum="A6B975BA901C64E5" modified="2014-10-01" version="1" fragment="single">CYDTSALSPKSGVVYSHARYGKEKYPSELHCSYEIRGTANSEFKVDIVDMDIEESGHYSGQFSVHLYTKIFEFIFALLAKGCYDTSALSPKSGVVYSHARYGKEKYPSELHCSYEIRGTANSEFKVDIVDMDIEESGQCLFDYMSIGAYESDDPYYFCGKDKPSFPILIPSSSLLITFASDAANDAKGFNLTYEAIEKEPLNTTQCGFAPKQKTVSKIARLIGGMPVTLGQWPWMVSLWDSGVFKCGASILNKNWLLTAAHCFAKDFTPSTWHAVVGDLLLDRFDTQEQHIEVKQIHIHPEYRSRGRYDNDIALIELKSPIIYGRTAIPICLESPDSQTTVEADALEPNSNVTCYIAGWGRSETQAVSNELRQLKLSFLSLAQCNKTEAYKGKLTSSMLCAGYMSGGKDSCKGDSGGPLMCQEEKSGRWFQLGIVSFGKQCAAPGTPGLYSRVSVFLDWIKSLAELEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJT5</accession>
    <name>A0A075AJT5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162387.1">
        <property type="nucleotide sequence ID" value="XM_009164123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJT5"/>
    <dbReference type="GeneID" id="20314566"/>
    <dbReference type="KEGG" id="ovi:T265_00378"/>
    <dbReference type="CTD" id="20314566"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="10133" checksum="0EFAA9B01AF9B8D7" modified="2014-10-01" version="1">MRSECIHWKLVCTVWTTMRFGRKLKIRRFRSYDDNLKVKWETVTQNTNRHHERRLSAYVLTAELIPGSLGATSNKQVMAPHKACDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTR7</accession>
    <name>A0A074YTR7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL608274">
        <property type="protein sequence ID" value="KER18161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178092.1">
        <property type="nucleotide sequence ID" value="XM_009179828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTR7"/>
    <dbReference type="GeneID" id="20330418"/>
    <dbReference type="KEGG" id="ovi:T265_16253"/>
    <dbReference type="CTD" id="20330418"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12181" checksum="D74D8985A646EDB1" modified="2014-10-01" version="1" fragment="single">RERARKIERNKQSVLFVSSFSRPYNRSDQLVSKLLSSEPNRLHAKCCEMLILTNEGLSDGNGTITGKNKSRNAVGSTVFAPQLSGSQHRSIRLSPGPQYLNSTSVEMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTZ5</accession>
    <name>A0A074YTZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604844">
        <property type="protein sequence ID" value="KER18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177982.1">
        <property type="nucleotide sequence ID" value="XM_009179718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTZ5"/>
    <dbReference type="STRING" id="6198.A0A074YTZ5"/>
    <dbReference type="GeneID" id="20330338"/>
    <dbReference type="KEGG" id="ovi:T265_16173"/>
    <dbReference type="CTD" id="20330338"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11256" checksum="64EE5E24282EF22D" modified="2014-10-01" version="1" fragment="single">RGILVHAVHDDGIVAEDGRIAVGDRLLAVNGVDLRDADHETGKKIIRNAGDSLRLLIYREPPTCLGETEQPQEIEVTIVRKPGESLGLSLFGRSPYSTGTAIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVL9</accession>
    <name>A0A074YVL9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IFT121 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598556">
        <property type="protein sequence ID" value="KER18703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177550.1">
        <property type="nucleotide sequence ID" value="XM_009179286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVL9"/>
    <dbReference type="STRING" id="6198.A0A074YVL9"/>
    <dbReference type="GeneID" id="20330044"/>
    <dbReference type="KEGG" id="ovi:T265_15879"/>
    <dbReference type="CTD" id="20330044"/>
    <dbReference type="OrthoDB" id="10260567at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="3">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER18703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14464" checksum="15749DAA3CDF7DD5" modified="2014-10-01" version="1" fragment="single">MNSFSNLLYFRSSKLAIVDDSGVLTMHLTTDGTPNGGALLEDRQKLNDFVRKDVWDIRFSEDNPDMFAIMEKTRMFIFDRLQASDTVQTSTFICSFHNLEVLGVLLDELVALEDQPSKDCLLRVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVR3</accession>
    <name>A0A074YVR3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XRRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597674">
        <property type="protein sequence ID" value="KER18861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177391.1">
        <property type="nucleotide sequence ID" value="XM_009179127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVR3"/>
    <dbReference type="GeneID" id="20329947"/>
    <dbReference type="KEGG" id="ovi:T265_15782"/>
    <dbReference type="CTD" id="20329947"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="2">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="17005" checksum="3A070319ABB146F3" modified="2014-10-01" version="1" fragment="single">IKILLASRTQHYLYAKQSQENCLWIANVHPFLDEHSLFEFFSQFGEVQQVEHHVIESGALVRFTDADTCRKILSTPMDSQYSIKLTKHDFPTATELLQSEWLTDYQLAKKHAEAELEAYFRQRLDKKTQVDEDGWIVVDKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW73</accession>
    <name>A0A074YW73_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597460">
        <property type="protein sequence ID" value="KER18933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177321.1">
        <property type="nucleotide sequence ID" value="XM_009179057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW73"/>
    <dbReference type="GeneID" id="20326261"/>
    <dbReference type="KEGG" id="ovi:T265_12093"/>
    <dbReference type="CTD" id="20326261"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7302" checksum="14436E037CB50A0E" modified="2014-10-01" version="1">MNTVDERCSPSRRLPAEEQFRPGLIQDTHVRINGFSPLAALSITEAIVLDNTTQFASRDLVWWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWG4</accession>
    <name>A0A074YWG4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL597330">
        <property type="protein sequence ID" value="KER19106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177146.1">
        <property type="nucleotide sequence ID" value="XM_009178882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWG4"/>
    <dbReference type="STRING" id="6198.A0A074YWG4"/>
    <dbReference type="GeneID" id="20326172"/>
    <dbReference type="KEGG" id="ovi:T265_12004"/>
    <dbReference type="CTD" id="20326172"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007263">
        <property type="term" value="P:nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF76">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="237"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER19106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="701" mass="79766" checksum="2CFC9D9570041D72" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWP6</accession>
    <name>A0A074YWP6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597335">
        <property type="protein sequence ID" value="KER19098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177155.1">
        <property type="nucleotide sequence ID" value="XM_009178891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWP6"/>
    <dbReference type="GeneID" id="20326177"/>
    <dbReference type="KEGG" id="ovi:T265_12009"/>
    <dbReference type="CTD" id="20326177"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="20357" checksum="EB66C84330BA3CBD" modified="2014-10-01" version="1">MPVGHKAKISLESWNLLNDNIEQQSLALSIDFPQKCRGVVDLDRWKASELRQFPLFIRPVVLRDILHCDFYECFKPFNFSHDNMLIFLIDVFKVSVSKFAAIYGPSHLVYNIHLFSRLFKFVKLYGSLDRFSCFPYESELGAIEALHTWSKTTGRSALPPTVRACGIGCCRKEDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ59</accession>
    <name>A0A074YZ59_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597095">
        <property type="protein sequence ID" value="KER20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176170.1">
        <property type="nucleotide sequence ID" value="XM_009177906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ59"/>
    <dbReference type="STRING" id="6198.A0A074YZ59"/>
    <dbReference type="GeneID" id="20325458"/>
    <dbReference type="KEGG" id="ovi:T265_11290"/>
    <dbReference type="CTD" id="20325458"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="384" mass="42384" checksum="AED5BE0F06A326B6" modified="2014-10-01" version="1" fragment="single">ARSIHAAFWIRDLVSTRSGHTRDVDVSEALVGSVGNIGKSVSQSTIQPTGQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINHQINQSINQSINQPINQSINQSINQSINHQSINQFNQLSIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ64</accession>
    <name>A0A074YZ64_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597094">
        <property type="protein sequence ID" value="KER20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176163.1">
        <property type="nucleotide sequence ID" value="XM_009177899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ64"/>
    <dbReference type="STRING" id="6198.A0A074YZ64"/>
    <dbReference type="GeneID" id="20325451"/>
    <dbReference type="KEGG" id="ovi:T265_11283"/>
    <dbReference type="CTD" id="20325451"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28797" checksum="6A8F25592FB0CBE2" modified="2014-10-01" version="1">MGTTACGWRRCKMCLLVDVSGALVFGFYSERMIWSGVVSVRSGYYTGGIFDLRLQIPSDFPSPELPRVYLPKGFFHPYVQAQTGELSITSAFSRWQPDRHHLWHVLHHVRSLLTSPTSCIREHSAEQIHMLTRSSIYPIDPADSSCMTYPNPEAADLIVNHKTLFEARARNCVMTLSLWSPSYKNGVDPLLDVYPISIDGWQDNTFIKRARERMKLEATPPPPDTSLSRGFSWIDTSTMTIFSNEPNNSKHGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ68</accession>
    <name>A0A074YZ68_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597094">
        <property type="protein sequence ID" value="KER20091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176168.1">
        <property type="nucleotide sequence ID" value="XM_009177904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ68"/>
    <dbReference type="STRING" id="6198.A0A074YZ68"/>
    <dbReference type="GeneID" id="20325456"/>
    <dbReference type="KEGG" id="ovi:T265_11288"/>
    <dbReference type="CTD" id="20325456"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131041" checksum="C0AB70EA25343499" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZQ6</accession>
    <name>A0A074YZQ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175994.1">
        <property type="nucleotide sequence ID" value="XM_009177730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZQ6"/>
    <dbReference type="GeneID" id="20325316"/>
    <dbReference type="KEGG" id="ovi:T265_11148"/>
    <dbReference type="CTD" id="20325316"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="1">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="13468" checksum="3290EF7A2E9C2630" modified="2014-10-01" version="1">MKQNTWFAVSSWIVFSGVSEWKLNINWEHMSRHQLFLFLLTGAFMSNACFPREKDICKHRYNTGGCFVTATTKYHFDVQKKQCVPYKDTCGNSENRFDTIDQCKMKCKHLMDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z089</accession>
    <name>A0A074Z089_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M16 inactive domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175786.1">
        <property type="nucleotide sequence ID" value="XM_009177522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z089"/>
    <dbReference type="STRING" id="6198.A0A074Z089"/>
    <dbReference type="GeneID" id="20329477"/>
    <dbReference type="KEGG" id="ovi:T265_15312"/>
    <dbReference type="CTD" id="20329477"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="202"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46749" checksum="4120D710EC959BBC" modified="2014-10-01" version="1" fragment="single">HAKLCQAGYHVRSAVTSAAAKPSTVPSPQLSTSEEGFQLACISQPSLWPCYSRVAIVFNAGSRYEREGKDRGITHLIRRSCGLSTFDHSAVNMTRHLQQMGARVTSTTTREHMIYTVDVAPNLVSRAGSILAELATGSVFYHWELKSIANKLMKKDIDLLNRRHLPALAMELLHEAAFGLNPLGSGLGYSLFAPADRVGSYTIDQIEKFHQYFFTPANTTIALVGHESDQDGLELLRHIKGGLKVRAPKTVPEKVTYVVTWLQHPASNETAFDLAASLLTGAIGRVAYSHGQTQTHLAPGNIDDGVEAVAFHKAYTGDGLFGVSVSGPTAQAVEGRLFNIVSAIRAAKFTTEELARAKALRKADILMSFESPLTLATDLAVQVSKPGHMYQSPEDRTAAVDKVFSQMAKSSRAALSVVGPEAGEVLPLTVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0W8</accession>
    <name>A0A074Z0W8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597328">
        <property type="protein sequence ID" value="KER19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177141.1">
        <property type="nucleotide sequence ID" value="XM_009178877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0W8"/>
    <dbReference type="GeneID" id="20329822"/>
    <dbReference type="KEGG" id="ovi:T265_15657"/>
    <dbReference type="CTD" id="20329822"/>
    <dbReference type="OrthoDB" id="6288808at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="609" mass="66742" checksum="C911A81190A7F112" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z356</accession>
    <name>A0A074Z356_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597114">
        <property type="protein sequence ID" value="KER19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176294.1">
        <property type="nucleotide sequence ID" value="XM_009178030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z356"/>
    <dbReference type="GeneID" id="20325557"/>
    <dbReference type="KEGG" id="ovi:T265_11389"/>
    <dbReference type="CTD" id="20325557"/>
    <dbReference type="OrthoDB" id="6240229at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705313" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18946" checksum="14FD0EC33AFBBA5C" modified="2014-10-01" version="1">MFRRIHIILVLLPTATRALCPPDYTRLSADVCTIQLNESRHFCDACNLCSNYGKQHNQLVFLHGRNVNLVKTILQPGSRAWNGMHGFLGIPEFKSVAGWRDLDPKTPEITSAPDLFKWAVNQPDGNQPNLAYHKKYDAMYDIHSGPANYVREVHCECALDSTCRSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z424</accession>
    <name>A0A074Z424_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit d 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit d 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_11160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597074">
        <property type="protein sequence ID" value="KER20257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176009.1">
        <property type="nucleotide sequence ID" value="XM_009177745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z424"/>
    <dbReference type="STRING" id="6198.A0A074Z424"/>
    <dbReference type="GeneID" id="20325328"/>
    <dbReference type="KEGG" id="ovi:T265_11160"/>
    <dbReference type="CTD" id="20325328"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="399" mass="44960" checksum="88EC9D9A373C6AF3" modified="2014-10-01" version="1">MKEITKSVGAVSATCLSGWGPRNLHCAWLGTLEDMAANQCITASTMVGVSSVSMLNFNADNGYLEGLARGIKSGLLKQSDYHVLVQCETLDDLKLHLQDTDYGDFLANEAGPLAVSTIEEKIRDKFVCEFRHLRHQAVEPLSTFLDYITYGYMIDNIVLLITGTLHARPIPELMTKCHPLGTFLEMEALHIASNPAELYNAVLVDTPLAPYFINCISEQDLDELNIEIIRNTLYKAYLEDFYAFCKAIGGKTAEVMCEILAFEADRRAFIITINSFGTELSNEDRSKLYPECGKLYPEGLTALSKANDYDQVKAVAGYYANYSSLFDDTGDNFGDKTLEDKFFEYEVQLNVSSFLHQFHFGIFYSLLKLKEQEMRNIVWIAECVSQRQRAKIDSYINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5U4</accession>
    <name>A0A074Z5U4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173811.1">
        <property type="nucleotide sequence ID" value="XM_009175547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5U4"/>
    <dbReference type="GeneID" id="20329019"/>
    <dbReference type="KEGG" id="ovi:T265_14853"/>
    <dbReference type="CTD" id="20329019"/>
    <dbReference type="OrthoDB" id="8187528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="279" mass="31854" checksum="D54B4CADA4FA168D" modified="2014-10-01" version="1" fragment="single">GRRWSDICPPEFRLVTFIDLTPRSSLFLCFIQDVWDGEEANIVNGILPLTTPSSCSFQLMKFTAPEADELDATENWVNRMYCKTTGACTPKGFMTLEPCYAESGYSIPLYLSFPYFMDADTRVTGRIDGVPKADRNKHRIYLLAEPVSPRLCSETQRYGNMSGPYYFPLAWVELEIVTPLAPVKFFKENILDLRHKVPYLMSILAVVCGIISLILIITFAFRLRFYRTHGSVNLALNLHDANDSPDTDKKEPIHFRIYHTLPESDSREILQSTSESDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z698</accession>
    <name>A0A074Z698_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596890">
        <property type="protein sequence ID" value="KER22603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173666.1">
        <property type="nucleotide sequence ID" value="XM_009175402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z698"/>
    <dbReference type="GeneID" id="20323534"/>
    <dbReference type="KEGG" id="ovi:T265_09365"/>
    <dbReference type="CTD" id="20323534"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6972" checksum="FF805A0270BBB049" modified="2014-10-01" version="1" fragment="single">CRSFLHLVKNLDRLFADRTTRVVQVCTLKAVCLLIAIYRRQIPPSGTSTWTEWQPVWHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6C0</accession>
    <name>A0A074Z6C0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596994">
        <property type="protein sequence ID" value="KER21107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175149.1">
        <property type="nucleotide sequence ID" value="XM_009176885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6C0"/>
    <dbReference type="STRING" id="6198.A0A074Z6C0"/>
    <dbReference type="GeneID" id="20329331"/>
    <dbReference type="KEGG" id="ovi:T265_15166"/>
    <dbReference type="CTD" id="20329331"/>
    <dbReference type="OrthoDB" id="6614329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF29">
        <property type="entry name" value="FOLLISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="45517" checksum="321DF4AE5C5B1134" modified="2014-10-01" version="1" fragment="single">TDGTCFTQRLSNGNCIGFISGVTTRQRCCEANGYFLNRVLTDYEFLRDHLIMETGTSNCVHACSEMYQPTCEDYICPEGHECQVLKGEPRCVCQTKCEPSDFESGVVCTTNLQQFTNRCQLKKARCESVHHGFSEIPCPQNQIKCASNSILSDLEKRSTDLLLAQSERRAVKMSPWIRQWLVDKRGTFQMERFRRKSLGGSIRVSRETQELEEWSSGLQCMNGEFCMLRQLNALPECVPWSKENKYGDCIEEDGTRGPFCGTNNRTYADRCELRHAGLRRQLEMRIAYMGQCRSDAMCENVKCPRSGMSCRLHHRTRQPVCVDCMQLPDDCNVSYQQQERPPEKRSEGDPVWTPQTNTKGWPTVCGSNGKVYSNACFLHVVNCFTDEFVELQHSSYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6L2</accession>
    <name>A0A074Z6L2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596988">
        <property type="protein sequence ID" value="KER21172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175088.1">
        <property type="nucleotide sequence ID" value="XM_009176824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6L2"/>
    <dbReference type="GeneID" id="20324617"/>
    <dbReference type="KEGG" id="ovi:T265_10449"/>
    <dbReference type="CTD" id="20324617"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="31639" checksum="E4483C0DDC601371" modified="2014-10-01" version="1">MFCLDSAESSVKTKLLYTGQIALRRNLVSHETLSGTGLHQKQAIEGSPPGKQNQRLSEKLSTVRELHIGIGEHSRKNRPPRNADEYQALLEDSAIAEHALDTGHKTDLENTYPAESLGFDVSRQLNVLHQATSCFSYYDVRNRRRGTGKGVENGLGSIEVTRVGVRSSEGGVVIIWIPLNLTHPLPKLCNIHMPTKIRGNLTEAPERPCGCHLILVVTRLLTSPLLQYEKSPVLSNKGDSDRKRLHTDTLTQQRMISSLKAHLQKALSNEDIHSVRNCSTSSLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7F7</accession>
    <name>A0A074Z7F7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">T265_08929</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173132.1">
        <property type="nucleotide sequence ID" value="XM_009174868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7F7"/>
    <dbReference type="STRING" id="6198.A0A074Z7F7"/>
    <dbReference type="GeneID" id="20323108"/>
    <dbReference type="KEGG" id="ovi:T265_08929"/>
    <dbReference type="CTD" id="20323108"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127468" checksum="3254A6C757599624" modified="2014-10-01" version="1"> </sequence>
</entry>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
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                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <dbReference type="EMBL" id="KER23053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">T265_11961</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KER19180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10044" checksum="ED8D0F633EBBC170" modified="2014-10-01" version="1">MLLWLGFALGTEITPPRVISAGLKPLYQFYAPCSTTLECLTISTPLAAKLWMESTPQLPDIGGNVESTDEERPALRAKSTIFRTLTYIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F7</accession>
    <name>A0A074Z9F7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER23738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009174230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9F7"/>
    <dbReference type="STRING" id="6198.A0A074Z9F7"/>
    <dbReference type="GeneID" id="20322608"/>
    <dbReference type="KEGG" id="ovi:T265_08429"/>
    <dbReference type="CTD" id="20322608"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="4">
        <location>
            <begin position="410"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="727" mass="81198" checksum="866E44F46FD10A35" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9G3</accession>
    <name>A0A074Z9G3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596912">
        <property type="protein sequence ID" value="KER22192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174049.1">
        <property type="nucleotide sequence ID" value="XM_009175785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9G3"/>
    <dbReference type="GeneID" id="20329083"/>
    <dbReference type="KEGG" id="ovi:T265_14917"/>
    <dbReference type="CTD" id="20329083"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="14756" checksum="1E610EFE66961AAC" modified="2014-10-01" version="1" fragment="single">MVVRSEAFVLNIAVFIRMGTSCQNNPMWLKREFTDRKVRGSNPTSASRLFLSRLWQPDSIPALVLSSGDIAARHRKGVTAERRFHFFGIQYIMIMSPIKSELERYVKQYRSIQCFEAASVFLSMLMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA08</accession>
    <name>A0A074ZA08_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172293.1">
        <property type="nucleotide sequence ID" value="XM_009174029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA08"/>
    <dbReference type="GeneID" id="20328682"/>
    <dbReference type="KEGG" id="ovi:T265_14516"/>
    <dbReference type="CTD" id="20328682"/>
    <dbReference type="OrthoDB" id="6246848at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="12030" checksum="B328E7D3FBF6963E" modified="2014-10-01" version="1" fragment="single">MVSPLRARQPAKWEVASTNQKLESYYNRKHGAKWRHSDIEKSVSVKDYHGNRVSWSQGEITRRIGNVIYDVEVAWQTWVRQANQLKQAYSRPADRVNVLYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAF0</accession>
    <name>A0A074ZAF0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_11205</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="KL597082">
        <property type="protein sequence ID" value="KER20185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176065.1">
        <property type="nucleotide sequence ID" value="XM_009177801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAF0"/>
    <dbReference type="STRING" id="6198.A0A074ZAF0"/>
    <dbReference type="GeneID" id="20325373"/>
    <dbReference type="KEGG" id="ovi:T265_11205"/>
    <dbReference type="CTD" id="20325373"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="381"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER20185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="597" mass="67900" checksum="D4C62B385F35C19E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB02</accession>
    <name>A0A074ZB02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171776.1">
        <property type="nucleotide sequence ID" value="XM_009173512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB02"/>
    <dbReference type="STRING" id="6198.A0A074ZB02"/>
    <dbReference type="GeneID" id="20328577"/>
    <dbReference type="KEGG" id="ovi:T265_14411"/>
    <dbReference type="CTD" id="20328577"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="24976" checksum="3331ED579D6AE8F3" modified="2014-10-01" version="1">MLSVGYIQNGVGSFSKRKLLTRLLKMLRQPTTSFAILGAHQKYTHLQINLFHVTKGRHVSSCICRTPPYFKSTTKRHDFELVAHQSQLDIRITNCFVTHMEHGSVVYFAILKILLPLLCLGIISSAIQTHGNQESSAPYQALVTLTGCCTILSNLFIVQFFVWLRDAGSWLAIGTSIAHYGIAMGISLLTFVLLFVGLGMLRLESPMKLCMFSRQSFHTIDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB97</accession>
    <name>A0A074ZB97_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597050">
        <property type="protein sequence ID" value="KER20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175757.1">
        <property type="nucleotide sequence ID" value="XM_009177493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB97"/>
    <dbReference type="GeneID" id="20329470"/>
    <dbReference type="KEGG" id="ovi:T265_15305"/>
    <dbReference type="CTD" id="20329470"/>
    <dbReference type="OrthoDB" id="10615971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="19050" checksum="B466379C4B239351" modified="2014-10-01" version="1" fragment="single">RYGQFSLISAHKDQEGHEFDWSGVCILAHARTKNEREFMEAWSSTEEAINKHIPATKSERTPKMQADCQARRTEQQPPDQQPINSPELAIFQQNFSAYSSLATPESRTVGIYKTAGHFQAASSQWQETMGAMFGGWSVCRAWQLARRRFVTDKENLIRERLGEMVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC53</accession>
    <name>A0A074ZC53_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_14323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171383.1">
        <property type="nucleotide sequence ID" value="XM_009173119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC53"/>
    <dbReference type="STRING" id="6198.A0A074ZC53"/>
    <dbReference type="GeneID" id="20328489"/>
    <dbReference type="KEGG" id="ovi:T265_14323"/>
    <dbReference type="CTD" id="20328489"/>
    <dbReference type="OrthoDB" id="6259803at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="254"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER24891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64952" checksum="3695136B5B2DB34C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCD5</accession>
    <name>A0A074ZCD5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cathepsin B-like cysteine proteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_07607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Thiol protease. Has a role as a digestive enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171435.1">
        <property type="nucleotide sequence ID" value="XM_009173171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCD5"/>
    <dbReference type="STRING" id="6198.A0A074ZCD5"/>
    <dbReference type="MEROPS" id="C01.062"/>
    <dbReference type="GeneID" id="20321786"/>
    <dbReference type="KEGG" id="ovi:T265_07607"/>
    <dbReference type="CTD" id="20321786"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="37610" checksum="36B9D79FB15E615E" modified="2014-10-01" version="1">MPWLILVFGTVLAAAGEVTGSIGMREYVDSETGAKWIYAEPPETFRQGNLQLMFRAIREPEEQRSKRPTVSHESLGDENIPKTFDAREQWPHCPTIGQIRDQSSCGSCWAFGAVEAMSDRLCIHSNGTFTKSLSSIDLVSCCGYCGFGCQGGYPPAAWDFWQAYGIVTGGSKEDPMGCRSYPFPKCSHHGSKKYPPCPHRIYDTPKCVPKCDTPNIDYETDKTRANITYNVQRSQMAIMKEIMINGPVEAAFEVYEDFLGYKQGVYFHSTGEFIGGHAIRILGWGEENGTPYWLIANSWNEGWGEDGYFKMLRGKNECGIEDEVTAGLPELSIIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCM7</accession>
    <name>A0A074ZCM7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171216.1">
        <property type="nucleotide sequence ID" value="XM_009172952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCM7"/>
    <dbReference type="STRING" id="6198.A0A074ZCM7"/>
    <dbReference type="GeneID" id="20321613"/>
    <dbReference type="KEGG" id="ovi:T265_07434"/>
    <dbReference type="CTD" id="20321613"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16294" checksum="1D184A72E8E09024" modified="2014-10-01" version="1">MTYHQMYRRTTLGNTLQEALDEMVEHKLLQQKTALKVIQKFDQCISLALAKRVKNRLSLKGHLNTYRFCDNVWTLVMNDVEIKDSSAIMTVDKIKIVACEGKSAKPTSASNVSKTTTSANPERQADAAPADEEKHTSYLSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCX2</accession>
    <name>A0A074ZCX2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009176945.1"/>
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    <dbReference type="STRING" id="6198.A0A074ZCX2"/>
    <dbReference type="GeneID" id="20324712"/>
    <dbReference type="KEGG" id="ovi:T265_10544"/>
    <dbReference type="CTD" id="20324712"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
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        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
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            <end position="326"/>
        </location>
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        </location>
    </feature>
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        </location>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KER21040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="714" mass="80695" checksum="F42D9AECD6785DDB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCX6</accession>
    <name>A0A074ZCX6_OPIVI</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="KER21045.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Opisthorchiata</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="160"/>
        </location>
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        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
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            <end position="237"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="487"/>
        </location>
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        </location>
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        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117498" checksum="B1DBECEAB1DE0273" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEH6</accession>
    <name>A0A074ZEH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596953">
        <property type="protein sequence ID" value="KER21625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174628.1">
        <property type="nucleotide sequence ID" value="XM_009176364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEH6"/>
    <dbReference type="GeneID" id="20324262"/>
    <dbReference type="KEGG" id="ovi:T265_10094"/>
    <dbReference type="CTD" id="20324262"/>
    <dbReference type="OrthoDB" id="6264453at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14185" checksum="B4AA22A1B6E329D6" modified="2014-10-01" version="1">MVLFVSIVFSILLQSVRMVTLEEGLKNPEKYIFYDQNPFNIGMHAGISLLITYSILAIVLGFIATISRALGYRRKRAILQFKSRLSGHPTMISVILAAQLISRCGPRHPRRQVQTRKIQFVKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEW7</accession>
    <name>A0A074ZEW7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P25-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170546.1">
        <property type="nucleotide sequence ID" value="XM_009172282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEW7"/>
    <dbReference type="GeneID" id="20321073"/>
    <dbReference type="KEGG" id="ovi:T265_06894"/>
    <dbReference type="CTD" id="20321073"/>
    <dbReference type="OrthoDB" id="6224953at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17226" checksum="25C6580F45307E48" modified="2014-10-01" version="1">MASSNADLKKAFLAYCSVIDHESTKGNSSCVRKMCTDSGINKTKMKQNDIDLEYVRCFGTSKEGIDFKAFLVFVEEYLGPVYGRMNGMEKEDAIAEVKQKLSCISPQLRNATKPSNDAVVQRLTDPNAFPQAHKSQPSAKPRQYNPAPGRQLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFS2</accession>
    <name>A0A074ZFS2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174166.1">
        <property type="nucleotide sequence ID" value="XM_009175902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFS2"/>
    <dbReference type="STRING" id="6198.A0A074ZFS2"/>
    <dbReference type="GeneID" id="20323905"/>
    <dbReference type="KEGG" id="ovi:T265_09737"/>
    <dbReference type="CTD" id="20323905"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15622" checksum="93FE012FAAFFAF23" modified="2014-10-01" version="1">MILFQIDAKSLPNGEPEHNELHAFQILDVPAQLVVEAINKARESEKKFPNIPVLICPEVEENYSSKPSSSGSIGDSYSRNTRKISLQGSTDSSNKIITATRPDEVAGQFDFKRFITNRGDIISALLRSVVVRSGGLVVMHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGG1</accession>
    <name>A0A074ZGG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="9"/>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169883.1">
        <property type="nucleotide sequence ID" value="XM_009171619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGG1"/>
    <dbReference type="STRING" id="6198.A0A074ZGG1"/>
    <dbReference type="GeneID" id="20328174"/>
    <dbReference type="KEGG" id="ovi:T265_14007"/>
    <dbReference type="CTD" id="20328174"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="523" mass="57694" checksum="E2D24A38054335D4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH15</accession>
    <name>A0A074ZH15_OPIVI</name>
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        </submittedName>
    </protein>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="32544" checksum="99E6501422BE2918" modified="2014-10-01" version="1">MLVYSTYGWGPRDPHCAWSEETLQDMAANRCQWRSCCQFLFRSPEALDDDGDDEDDDDDDDDIVRTFYYKHKTVSNLPSFVNADDPLFGSNMSKEFGSNLSVLSTCDGILRSHPVVVSAGVEAQSCLLRAEVRVICGRTQFPGVAAHVRCLHGRSVVPRTGVLGVTGRIRYCQPGLQEPQACLRLKVFGGRGRVVKMPVHNLSTRSWLLDRPAYMAECVRPTVPLRNDPRGWYFLYGSVGAFHQTAPLWVVRCCPRFMDPQECTYFPQQVALKGWALIRVENDWYPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_06237"/>
    <dbReference type="CTD" id="20320419"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER26518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11625" checksum="1CDA4DB3B7786889" modified="2014-10-01" version="1">MESPRLGVQAANQENMLSICGDHFVFIHFLGALLKRMTNQNIYCPVHTESHWKQDSADNQENKRELKMIGLFRADQDGRPFQRPASGPHIGALKLPADPVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHN1</accession>
    <name>A0A074ZHN1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER26773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171225.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZHN1"/>
    <dbReference type="GeneID" id="20320237"/>
    <dbReference type="KEGG" id="ovi:T265_06055"/>
    <dbReference type="CTD" id="20320237"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="465"/>
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        </location>
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    <feature type="domain" description="TANC1/2-like winged helix" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like winged helix" evidence="8">
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF25521"/>
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        <source>
            <dbReference type="EMBL" id="KER26773.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1991" mass="217008" checksum="9FA3F9246A843708" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHT6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169394.1">
        <property type="nucleotide sequence ID" value="XM_009171130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHT6"/>
    <dbReference type="GeneID" id="20320160"/>
    <dbReference type="KEGG" id="ovi:T265_05978"/>
    <dbReference type="CTD" id="20320160"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8942" checksum="F45C27AD3FCF639B" modified="2014-10-01" version="1">MELNSHILASRLERFIMPAEMEPLDASNKAIKHDQSTFSIKETTHKVAENSLTTHDLFRTSWGLSDRRSPRVSVNLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHV3</accession>
    <name>A0A074ZHV3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169415.1">
        <property type="nucleotide sequence ID" value="XM_009171151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHV3"/>
    <dbReference type="STRING" id="6198.A0A074ZHV3"/>
    <dbReference type="GeneID" id="20320181"/>
    <dbReference type="KEGG" id="ovi:T265_05999"/>
    <dbReference type="CTD" id="20320181"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="44632" checksum="D31F6700503C6A47" modified="2014-10-01" version="1">MGSLPCLFLNPTGPPRVASTLSLPHTGIGPSQISVLPPAGFQHLGLSNFPPTASLTRSLLSISTLHDAAGHMNSPRLRATSCQPLSRTTINRFTEPRLFFPESTHDNAQPLDLTLKSSADVKATTDSQLHHDPGALQPVPPCSEHVCSTVNHTNSLVTNVENNEKTMVHQLDRGSSQRRRKTMSSCTTKSPYPSGITEGKNPQSTVPEDAYKMFRGRTVVERALLSTVSDNEEYVAVSNGDDQTSPSFVTVHLLRPRRSQSANEDRFVNGKYNDPETKEVSSISKDSKPIESGDSLKDDVKLVKTFKVVHEKADSSVCNPRMRRFPEMTPREVKDETYWEKRVKNNEAARRSRRARKTKETKLREYAEKLEKTNAKLLGEIEILKSEVCRLKSSKLDAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIL7</accession>
    <name>A0A074ZIL7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169392.1">
        <property type="nucleotide sequence ID" value="XM_009171128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIL7"/>
    <dbReference type="GeneID" id="20320158"/>
    <dbReference type="KEGG" id="ovi:T265_05976"/>
    <dbReference type="CTD" id="20320158"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="10020" checksum="1EA0794ADE072D5C" modified="2014-10-01" version="1">MCARSGSPGITTDSTESLVHGILQLNVLHTGRVMFQLARFKQNIRLTETRGLRLPDEPQEERNRLWAIEVFRNLRTQESLLNFITPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK38</accession>
    <name>A0A074ZK38_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168820.1">
        <property type="nucleotide sequence ID" value="XM_009170556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK38"/>
    <dbReference type="STRING" id="6198.A0A074ZK38"/>
    <dbReference type="GeneID" id="20319704"/>
    <dbReference type="KEGG" id="ovi:T265_05522"/>
    <dbReference type="CTD" id="20319704"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41794" checksum="E36AE673627E7680" modified="2014-10-01" version="1">MADEEIQQLVCDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNTPAMYVGIQAVLSLYASGRTTGVVLDSGDGVSHTVPVYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESSGIHETSFNSIMKCDVDIRKDLYANTVLSGGTTMFPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEIRRAGPGIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKC9</accession>
    <name>A0A074ZKC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168507.1">
        <property type="nucleotide sequence ID" value="XM_009170243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKC9"/>
    <dbReference type="GeneID" id="20327905"/>
    <dbReference type="KEGG" id="ovi:T265_13738"/>
    <dbReference type="CTD" id="20327905"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11514" checksum="00D1D128DC7C1C65" modified="2014-10-01" version="1" fragment="single">ETTHKVAENFSTAHDRFRPSWGSSDRRSPRVSVNLMIYLNEATHKNTEKSSTAHDRFRPSWGSSGRRSPLVSVNFMFYLNPNRTDFYKYTHLQMIFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKG5</accession>
    <name>A0A074ZKG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_13708</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168422.1">
        <property type="nucleotide sequence ID" value="XM_009170158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKG5"/>
    <dbReference type="STRING" id="6198.A0A074ZKG5"/>
    <dbReference type="GeneID" id="20327875"/>
    <dbReference type="KEGG" id="ovi:T265_13708"/>
    <dbReference type="CTD" id="20327875"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF244">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="16">
        <location>
            <begin position="135"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER27823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="620" mass="69057" checksum="6295B3D880766BF9" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLD1</accession>
    <name>A0A074ZLD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169636.1">
        <property type="nucleotide sequence ID" value="XM_009171372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLD1"/>
    <dbReference type="GeneID" id="20320353"/>
    <dbReference type="KEGG" id="ovi:T265_06171"/>
    <dbReference type="CTD" id="20320353"/>
    <dbReference type="OrthoDB" id="6142323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="23256" checksum="26577D934BFF9257" modified="2014-10-01" version="1">MRRRCKSKIRQQNIRKQVTILETSPGKTKSWPPATQPVEIMHTGEWNVNLDRTSEEEIRYEIAVLMCDSEALPSSKKAEIPWWPTLQSLLVLCGTKRKCLKNGPCRHMAVRHRKGATAERFFLSTVIPVFKKGTRTLCENYRGISLPLTVLDLCTNLSARACNAQLPNPPIIGERNCGSYNHCTTSTRFLQLTMMMMMMIRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLN4</accession>
    <name>A0A074ZLN4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Legumain prodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168221.1">
        <property type="nucleotide sequence ID" value="XM_009169957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLN4"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20319228"/>
    <dbReference type="KEGG" id="ovi:T265_05046"/>
    <dbReference type="CTD" id="20319228"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Legumain prodomain" evidence="3">
        <location>
            <begin position="378"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="439" mass="50910" checksum="784872E84DF3209B" modified="2014-10-01" version="1">MKRLAMFFLPNDVQKNKFWRIHIGAFKEKRYNTALVRDTGLHQLWFVDAAFDRGLKDVLANVYHAYHVLRANRIPAENIIPIAYDDIANNPKNPFKGQVFHDYTHKDVYKDVVIDYRGKDVKPFFFTKVLTGDKKLEREGKKVLKSGPDDNVFVYYSGHGAYRYISFPEGQLNAAEFNDIFAHMHLKRKYNKLVLYMDSCNSGSMFLDILPPDVGIYVTTSAKEDEDSWAIFCDDRRIDACLATEYSYDWITDSETSDLKKRTLDQQYEEVKRRTKDSHVRKYGEMTMGSLPVGKFQGHYDLLMHQNGGAIAPNVVDKKPSSRVHLFSMSRRLMEATTEEEHEIAWRKLHRALQLGHIVKETFHEIAMDVTTHHKPTVKGLSKRDELMCFKAVFDHFRTHCFTIQQVPEVAQHTVHLMELCKAGYEAETLIQSVHTVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLQ5</accession>
    <name>A0A074ZLQ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596816">
        <property type="protein sequence ID" value="KER24295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171981.1">
        <property type="nucleotide sequence ID" value="XM_009173717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLQ5"/>
    <dbReference type="STRING" id="6198.A0A074ZLQ5"/>
    <dbReference type="GeneID" id="20322209"/>
    <dbReference type="KEGG" id="ovi:T265_08030"/>
    <dbReference type="CTD" id="20322209"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8284" checksum="D2EC9AC2D47B7F6D" modified="2014-10-01" version="1">MQELQGHMQLHGAEGLDVTTRKYDGVTELCKRLSTSQTEGLFNKELTQRGEVFGANVIPPTPPKTFLQLRWAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNJ9</accession>
    <name>A0A074ZNJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168881.1">
        <property type="nucleotide sequence ID" value="XM_009170617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNJ9"/>
    <dbReference type="STRING" id="6198.A0A074ZNJ9"/>
    <dbReference type="GeneID" id="20327972"/>
    <dbReference type="KEGG" id="ovi:T265_13805"/>
    <dbReference type="CTD" id="20327972"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000104">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER27362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="794" mass="89216" checksum="918A792EF3141B72" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNR8</accession>
    <name>A0A074ZNR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER27437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009170582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNR8"/>
    <dbReference type="STRING" id="6198.A0A074ZNR8"/>
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    <dbReference type="KEGG" id="ovi:T265_13802"/>
    <dbReference type="CTD" id="20327969"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="224" mass="24689" checksum="02D44C4EF53AE5C2" modified="2014-10-01" version="1" fragment="single">MEDVGDRKTPIIVNETKDNSSGEENAKQSDSTLSSDGVDSDDPSPDQHSDSSSDVIRLITSTRNLLRASLTSSTEDHPFKTGPDELNPEVDIPSPIEMDTECSPVVYVTQDVVESKFDDISSACEPTTSSNECLDPSQVFRDDPPQSEDLPSSELQPDLQKPTKTPLFLEQVNIPRRQTEHFKSSSTTGDYQVSSRVCEKESVAALPDFLPYSQRTQGSMKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSI8</accession>
    <name>A0A074ZSI8_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER26330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSI8"/>
    <dbReference type="STRING" id="6198.A0A074ZSI8"/>
    <dbReference type="GeneID" id="20320562"/>
    <dbReference type="KEGG" id="ovi:T265_06383"/>
    <dbReference type="CTD" id="20320562"/>
    <dbReference type="OrthoDB" id="6262303at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045323">
        <property type="entry name" value="CCDC34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025259">
        <property type="entry name" value="CCDC34/181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247">
        <property type="entry name" value="NY-REN-41 ANTIGEN L15 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13904">
        <property type="entry name" value="CCDC34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="3">
        <location>
            <begin position="212"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="397" mass="45145" checksum="B3383117E9C8049E" modified="2014-10-01" version="1">MSLSNIKYDSQDSSPDSAASSSTADLLKILSKSDVILEDSLSASDLSLDATRIPYNGPKDVHTDRYATKRPPRNRSISGPGKSGTRNQVRPLRRHTLDSLEKTNSAAHPGFAQSLKRHITVAKPSLSTVNTKLVRQRSCPRTRKDQGAQEQRVDDAICHREDESNTPSYSLDFTDDLCSHSRPDEIEQDPNLLDSSSKNSDRSAIATKVEELTPWERWLLQKEKIRRQELKRLRQKEANLRAKQAQAAASQAEKEQRSLAKCKEWLESKQRLLKERNEAAAMARKEQLLKERFKKESKKLESERKYALWCEQKKHEAKETAELIRQKELAAAASAQRRKEEAMVKFVAWMKSAQQRKPNPPVSYGYADGTVICYFDRSANPKPSYINPNPWISPMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSJ8</accession>
    <name>A0A074ZSJ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165811.1">
        <property type="nucleotide sequence ID" value="XM_009167547.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSJ8"/>
    <dbReference type="GeneID" id="20317321"/>
    <dbReference type="KEGG" id="ovi:T265_03134"/>
    <dbReference type="CTD" id="20317321"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
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        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
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            <end position="735"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="2115"/>
        </location>
    </feature>
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            <end position="355"/>
        </location>
    </feature>
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            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="645"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
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            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1851"/>
            <end position="1864"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2115" mass="242347" checksum="596A4F0C6EA89E90" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSN5</accession>
    <name>A0A074ZSN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167415.1">
        <property type="nucleotide sequence ID" value="XM_009169151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSN5"/>
    <dbReference type="GeneID" id="20327671"/>
    <dbReference type="KEGG" id="ovi:T265_13504"/>
    <dbReference type="CTD" id="20327671"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10276" checksum="50C3910008C9C95F" modified="2014-10-01" version="1">MLTFVVIMFGVCWLPSHVYFLLSDFTNLIDQLGPDNSRIAYGVCHWIAMSNSFVNPIIYLLMSKSFKDPTWTVSQNTIKIHLSSSSARDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTA0</accession>
    <name>A0A074ZTA0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_04247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167204.1">
        <property type="nucleotide sequence ID" value="XM_009168940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTA0"/>
    <dbReference type="STRING" id="6198.A0A074ZTA0"/>
    <dbReference type="GeneID" id="20318433"/>
    <dbReference type="KEGG" id="ovi:T265_04247"/>
    <dbReference type="CTD" id="20318433"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER29062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9068" checksum="3F2D4FCD88B8B96D" modified="2014-10-01" version="1">MSANQRMKVQNERAHGNVRNRGNVPKSLKSQDSQSNMNAWILGLIVFVVCGSGWRIPNSGEFTRSVVCTLPSASSSYINSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTE7</accession>
    <name>A0A074ZTE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_03132</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165809.1">
        <property type="nucleotide sequence ID" value="XM_009167545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTE7"/>
    <dbReference type="STRING" id="6198.A0A074ZTE7"/>
    <dbReference type="GeneID" id="20317319"/>
    <dbReference type="KEGG" id="ovi:T265_03132"/>
    <dbReference type="CTD" id="20317319"/>
    <dbReference type="OrthoDB" id="6258810at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="69"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="268"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="474" mass="53081" checksum="680BCF769B940C35" modified="2014-10-01" version="1">MVNVTTDYRHYKLVWRTAGMRECISVHIGQAGTQIGNACWELYCLEHGIQPDGTAIISESSPEDDRSSFATFFSEVGSERHVPRAIFVDLESTVVDEIRTGVYRHLFHPEQIISGKEDAANNYARGFYTIGKDLIEKVLDRIRKMTDQCSGFQGFLMFHSFGGGTGSGFTSLLMERLSNEYGKKTKLEFAVYPAPHISSAVVEPYNTILTTHTTLEHSDCTFMVDNEAIYEICNRNLAIERPSYRNLNRLIGQVVSSITASLRFKGALNVDLTEFQTNLVPYPRVHFPLTAYAPVISAEKARHEQLSVAEITSACLDPSNQMVKCDPRRGKYMACCLLYRGDVIPKEVNAAINKIKTRTSVHFVDWCPTGFKVGLNQQPPSVVPGGDLAKVPRALCMLSNTTAIAEAWKRLDQKFDLMFAKRAFVHWYVGEGMEEGEFSEAREDIAALEKDYEEVGLDSIGGEQDDHSDISETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG0</accession>
    <name>A0A074ZTG0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165823.1">
        <property type="nucleotide sequence ID" value="XM_009167559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG0"/>
    <dbReference type="GeneID" id="20317333"/>
    <dbReference type="KEGG" id="ovi:T265_03146"/>
    <dbReference type="CTD" id="20317333"/>
    <dbReference type="OrthoDB" id="6268813at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45531" checksum="151C45FB5D5BAA20" modified="2014-10-01" version="1">MLETCWTHFVNFAYLYVDSTVEFQKRFLLLIFRIVKPTCDSKFRVGKNDTVDFNEISNDNTSFVFSNFRLMIFMLYGYVKLQPVLLETHIHTVLDHIHYECAPFTQSDFQAVYTDFINILDLIIHRLGNQPKPKLNDRFVIHAVTSLMKAFGRRLQDYFNSSTLFQQPTRFMCAFQAVAKNEIARVTWEWNYDIIIKRITGNVLVICSKRIKALKNITTGGFAIFSGLVYTELLEPSPNMVLDISFKLPIEFITVDYICARYNPTAKKDKYLWDTRDSCSMKERKGTTIRCICRQTGYYAILYPQKDIEAIGIKFYGILRSYRMYLVHAVTSGFLLFGLSYLLAVQLKIKQNKSPVDSEALSYIAAFKFYAAKFAKVMKKSILRTGPELALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTY2</accession>
    <name>A0A074ZTY2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166929.1">
        <property type="nucleotide sequence ID" value="XM_009168665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTY2"/>
    <dbReference type="STRING" id="6198.A0A074ZTY2"/>
    <dbReference type="GeneID" id="20318216"/>
    <dbReference type="KEGG" id="ovi:T265_04030"/>
    <dbReference type="CTD" id="20318216"/>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="8">
        <location>
            <begin position="107"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="496" mass="57679" checksum="C916D11CB75FCDBA" modified="2014-10-01" version="1">MTQIARELEEVEERLARCQTKMQELQISVNAEKAKMDTVEDTVFHDFCVQIGVDNIRQYEDRELRVARERDRKRLEFTNQLQRINNQLDYERSRDTEGAVKRWEETVAAEKIEMDKCKKQEKKVKEEMEQEERRKTELESRLGDLKLRAEELDMELSEVKRRLVAKQRDIQKQQKELNQSEARLESRRAERHSLLQSAKMEDLEIPLKPGASPIAELESQLSADPESLDPSSEEMARIYELEARLPIDFKRLEKPLRQLSDDKDISRKAEELQNQVDSMLNNLSRIQAPNLRAGDKLGSVEERLRSTEAEFEDTRRRAKRAKARFERVRRLRYNAFMNCFLSITDNIDPIYKSLSRNPGAQASLLPTNAEEPYLEEIQFQCVAPGKRFQQMDSLSGGEKTIAALALLFAMHRYNPSPFFVLDEIDAALDNTNIGKVASFIREYATQRAQIIVISLKEEFYSRADSLIGIYPDIENNCLVSRVLSFDISKYIDTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU79</accession>
    <name>A0A074ZU79_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165272.1">
        <property type="nucleotide sequence ID" value="XM_009167008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU79"/>
    <dbReference type="GeneID" id="20316894"/>
    <dbReference type="KEGG" id="ovi:T265_02706"/>
    <dbReference type="CTD" id="20316894"/>
    <dbReference type="OrthoDB" id="6138332at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19424" checksum="43EE54D80A01B833" modified="2014-10-01" version="1">MSFRNSRSRLATWCPPTTGRPQTQIDHIAISYRWRGSITDCRSFWNTFVDSDHALVRSRFSLRFPGPRKVRTNRMATRRLADPDVRQTYKNRLLESLPSAPPSNVNSYWDEIATSLLRAGNFAWKTPGYTYTSPLKGRRPSLQKTPTELLHTIEQESKTHMHLVYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUF4</accession>
    <name>A0A074ZUF4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_05851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169236.1">
        <property type="nucleotide sequence ID" value="XM_009170972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUF4"/>
    <dbReference type="GeneID" id="20320033"/>
    <dbReference type="KEGG" id="ovi:T265_05851"/>
    <dbReference type="CTD" id="20320033"/>
    <dbReference type="OrthoDB" id="6242979at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="956"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="144"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="275"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="408"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="519"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="644"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="788"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="877"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER27020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1278" mass="139812" checksum="48F98278CDF49838" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV03</accession>
    <name>A0A074ZV03_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169056.1">
        <property type="nucleotide sequence ID" value="XM_009170792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV03"/>
    <dbReference type="GeneID" id="20319901"/>
    <dbReference type="KEGG" id="ovi:T265_05719"/>
    <dbReference type="CTD" id="20319901"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13632" checksum="E60E4C901AF7E1CE" modified="2014-10-01" version="1">MGVVSRLNNASLFLKHTGKGVNGSIVHGVLQTNELRYNETVWQPAIKHTSMQMRFECNNMRDGLELDQCAHMRSLRIEQGEKFSGRWSGGSPSLARQIAPYRQVFPRFVLAYRREIPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVD9</accession>
    <name>A0A074ZVD9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166425.1">
        <property type="nucleotide sequence ID" value="XM_009168161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVD9"/>
    <dbReference type="GeneID" id="20317813"/>
    <dbReference type="KEGG" id="ovi:T265_03626"/>
    <dbReference type="CTD" id="20317813"/>
    <dbReference type="OrthoDB" id="6241907at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704319" evidence="2">
        <location>
            <begin position="17"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="45619" checksum="DA56B319C0E9D3FF" modified="2014-10-01" version="1">MFLNLLFVGGWTAVPAYLDPPKIIPVGPVDTTTVLTAAQKQNNQRTNIVEDKPRLIGTGTLEDPIDLTGRVPNSVTELIIQSQSTCASVKHDLQWRCENSFLTWQALKLIPGTLEDEVSIRIQDEMKRTAHVPAYLDPPKIIPVGPADTTTVLTAAQIQNNQRTNIVEDKPRLIGTGTLEDPIDLTGRVPNSVTELIIQSQSTCASVKHDLQWRCENSTRSFSLRPSVVQAIPDTGTRRLGTLSFAPQLPCPNGLYSITGQVRIGCDSRMKTSSSSDRGTRENALVGLNRIKCTPNHGRDQAFIDQTFSREAANLYAQRISSMQLTSSGFYDDCLPIDPTQRNKQRSACVYVLCPGPVEPWFTLSERVAIAVSVPVFILLCLLLCYVTQRRRRSKQKSNLAPGQNHEIELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW91</accession>
    <name>A0A074ZW91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164794.1">
        <property type="nucleotide sequence ID" value="XM_009166530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW91"/>
    <dbReference type="STRING" id="6198.A0A074ZW91"/>
    <dbReference type="GeneID" id="20316504"/>
    <dbReference type="KEGG" id="ovi:T265_02316"/>
    <dbReference type="CTD" id="20316504"/>
    <dbReference type="OrthoDB" id="10050940at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="357"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="587" mass="67108" checksum="F75F81BDF1B76031" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWM8</accession>
    <name>A0A074ZWM8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597175">
        <property type="protein sequence ID" value="KER19584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176674.1">
        <property type="nucleotide sequence ID" value="XM_009178410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWM8"/>
    <dbReference type="GeneID" id="20325859"/>
    <dbReference type="KEGG" id="ovi:T265_11691"/>
    <dbReference type="CTD" id="20325859"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="10346" checksum="DC26F899BDACC3C3" modified="2014-10-01" version="1">MPTLGSSHESCVHLNSRDYKTTHNKSINSAFKQEEEQEDEYEYENEDEEEEEDEYEYEDEDEDDDKDENEDEDEDYDENEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWR5</accession>
    <name>A0A074ZWR5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164656.1">
        <property type="nucleotide sequence ID" value="XM_009166392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWR5"/>
    <dbReference type="STRING" id="6198.A0A074ZWR5"/>
    <dbReference type="GeneID" id="20316392"/>
    <dbReference type="KEGG" id="ovi:T265_02204"/>
    <dbReference type="CTD" id="20316392"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="628" mass="66508" checksum="A23774D596BEAA3F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX44</accession>
    <name>A0A074ZX44_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597145">
        <property type="protein sequence ID" value="KER19739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176512.1">
        <property type="nucleotide sequence ID" value="XM_009178248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX44"/>
    <dbReference type="STRING" id="6198.A0A074ZX44"/>
    <dbReference type="GeneID" id="20325733"/>
    <dbReference type="KEGG" id="ovi:T265_11565"/>
    <dbReference type="CTD" id="20325733"/>
    <dbReference type="OrthoDB" id="6232912at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="231" mass="25297" checksum="A81572E0257DD6A1" modified="2014-10-01" version="1">MQPAWQNVPTNGVITTQPTNVHPITGQKEWENQLWDLPDFGTFALSCLCPWAVMASVAEDVGYSYSWCCFASLCTLATFQWPCHCLLGCIVRGRVRRTFNIRGNPCCDLCAYCCCYSCTLNQAALQVEYELARARGRQNTTGFSIRLGQRQFMVGAQKVDPPPMIPLVPTQQPNPVSTMSNPLTSPLLTPVQATLPTASTEVGYTNGTAQVVPQNQTPAEDNSIPTLSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXA5</accession>
    <name>A0A074ZXA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_05106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168287.1">
        <property type="nucleotide sequence ID" value="XM_009170023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXA5"/>
    <dbReference type="STRING" id="6198.A0A074ZXA5"/>
    <dbReference type="GeneID" id="20319288"/>
    <dbReference type="KEGG" id="ovi:T265_05106"/>
    <dbReference type="CTD" id="20319288"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="11">
        <location>
            <begin position="597"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="716"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="977"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="907"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER27985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1186" mass="135653" checksum="CB07DCD1E189702D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY55</accession>
    <name>A0A074ZY55_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597091">
        <property type="protein sequence ID" value="KER20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176143.1">
        <property type="nucleotide sequence ID" value="XM_009177879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY55"/>
    <dbReference type="GeneID" id="20325437"/>
    <dbReference type="KEGG" id="ovi:T265_11269"/>
    <dbReference type="CTD" id="20325437"/>
    <dbReference type="OrthoDB" id="10438282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="18759" checksum="169B278703B5D150" modified="2014-10-01" version="1">MVRGSDSISSDFFCGQRGSIAAVVLPSSGVTARHPKDGSCHLIPHHLQFSCLPFIVQQSIQIGRGDIMEAGSIALLDTGSSKIFLPAYIFYELKRILDGRRMLSDRFLVDCSKFGRFPPIHLLIAKHRFTLHAEDYIVRVIVYFEFHCISDILIVDKASITLFSGWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY99</accession>
    <name>A0A074ZY99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164207.1">
        <property type="nucleotide sequence ID" value="XM_009165943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY99"/>
    <dbReference type="GeneID" id="20316021"/>
    <dbReference type="KEGG" id="ovi:T265_01833"/>
    <dbReference type="CTD" id="20316021"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="399" mass="42711" checksum="CC6F9BB2C9672070" modified="2014-10-01" version="1">MTLTTNNTLMPHRPSRGAMSRVALLAAYNRAVLKPRRPVYLAAFNVCTLKQTGQKAALAPTPESLGIDVCCVSETTIQDASTVIELTAPSVSTRFRVRTSGDPEAAAAGCAGVGIVLSHRVEVSLLDWMPVDSRLCAVRLATSVKESQKREVHRCLLIVSVYAPTDFSSDSVKGRFYDALNAPLQRVRSSDIVVGGGDMYAQVGRLSASETQLGGRHGLDSPAASTHLEPTDEAEPWTVNVKPPAAPEVYGCICPLKRHRAPGPDDLPPALFKDGDEVLSQRLSDLFACIWEKESVPDNWEASAIVPVFQKGRVVYFRQVFLVESATNCVSAWSSGTGAAGLIGALSYAALTSVLSPETTLLLVTMVPVSLLLVFGEMFTVAADAGDLIIGSEAEEWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYJ8</accession>
    <name>A0A074ZYJ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597076">
        <property type="protein sequence ID" value="KER20229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176022.1">
        <property type="nucleotide sequence ID" value="XM_009177758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYJ8"/>
    <dbReference type="GeneID" id="20325337"/>
    <dbReference type="KEGG" id="ovi:T265_11169"/>
    <dbReference type="CTD" id="20325337"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13649" checksum="7EE62B4126C57C42" modified="2014-10-01" version="1">MTDTPKQHLCKCFVTVSDLMKRLEYLNVGLVFDVGNEYRYLSNVHAIWCSPAVTNHDHQELELSSFRESSPHFLAQGPSSCISLGVLAKDDICVRTGKARAVLVNLHHLWHRCDINLSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYV5</accession>
    <name>A0A074ZYV5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164052.1">
        <property type="nucleotide sequence ID" value="XM_009165788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYV5"/>
    <dbReference type="GeneID" id="20326995"/>
    <dbReference type="KEGG" id="ovi:T265_12827"/>
    <dbReference type="CTD" id="20326995"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="26084" checksum="EA01BDCB0933A582" modified="2014-10-01" version="1" fragment="single">KEYTHLQINLGFTRDSTESLVYDILQLNVLHTGRLVFQLARYSSFQQPWHLSVRLRESSTKFLSARRPKWLEREITDRKVRGSNPSSASRLPLSRLGQPGSIPALVQPSGGMAVRHRKGATAERLNKKISPWGFKYNWTNLMIDWSTHASIKVSYREPQPATAGTLPRLYDRLEWWKIENYRLPEANRHRSHLKPLISTHKVRVRQCCLIDVRQHFPKQHFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ95</accession>
    <name>A0A074ZZ95_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164880.1">
        <property type="nucleotide sequence ID" value="XM_009166616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ95"/>
    <dbReference type="STRING" id="6198.A0A074ZZ95"/>
    <dbReference type="GeneID" id="20316571"/>
    <dbReference type="KEGG" id="ovi:T265_02383"/>
    <dbReference type="CTD" id="20316571"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="358"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="781" mass="87564" checksum="8271FB4A92B56AE5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZQ9</accession>
    <name>A0A074ZZQ9_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">T265_01041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZZQ9"/>
    <dbReference type="GeneID" id="20315229"/>
    <dbReference type="KEGG" id="ovi:T265_01041"/>
    <dbReference type="CTD" id="20315229"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeobox protein aristaless"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="677"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
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            <end position="738"/>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="759" mass="84253" checksum="46D81E34930A50CE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZS6</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_01059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZS6"/>
    <dbReference type="GeneID" id="20315247"/>
    <dbReference type="KEGG" id="ovi:T265_01059"/>
    <dbReference type="CTD" id="20315247"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="21128" checksum="F7F36FB2C86AE842" modified="2014-10-01" version="1">MTRFNSLSVTVTQRMADADKYDEQPLCAQLITKNIDVWAIGAMLGKCSLHQKNNGHPIYDVRLNSKVIPEGYQGKANLFGWYVNTQVLPDGNCDTTIDVPGRPHLSNKALVFLTGPEDNNICHKLREATLGGVRIVNCYQIKTEIVEVQKLGTYHIETEKGVDYSTVQLLAEKANEGQTGCAYNAFPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I9</accession>
    <name>A0A075A1I9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I9"/>
    <dbReference type="GeneID" id="20314678"/>
    <dbReference type="KEGG" id="ovi:T265_00490"/>
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    <dbReference type="OrthoDB" id="6256441at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="62501" checksum="97A6DB35D0194055" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1K7</accession>
    <name>A0A075A1K7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1K7"/>
    <dbReference type="STRING" id="6198.A0A075A1K7"/>
    <dbReference type="GeneID" id="20326735"/>
    <dbReference type="KEGG" id="ovi:T265_12567"/>
    <dbReference type="CTD" id="20326735"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="404"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="872" mass="97024" checksum="002AF9CF5955950A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1W8</accession>
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        </recommendedName>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176594.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075A1W8"/>
    <dbReference type="GeneID" id="20324442"/>
    <dbReference type="KEGG" id="ovi:T265_10274"/>
    <dbReference type="CTD" id="20324442"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="70"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
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            <end position="358"/>
        </location>
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    <feature type="repeat" description="RCC1" evidence="3">
        <location>
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        </location>
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        <location>
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            <end position="580"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="838" mass="86874" checksum="FC4E2D3A43D96D41" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A240</accession>
    <name>A0A075A240_OPIVI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
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        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A240"/>
    <dbReference type="GeneID" id="20324373"/>
    <dbReference type="KEGG" id="ovi:T265_10205"/>
    <dbReference type="CTD" id="20324373"/>
    <dbReference type="OrthoDB" id="6231043at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="27557" checksum="11ED0E58DD4BE035" modified="2014-10-01" version="1">MMPRSTKKEGDTEATQSPAPPAPLPPPPPETEADPVAPEAHFLHIPGGITAYTLSKWQVKLDLPYINGVLAVGYTVIGALLCFFSLVLLPYNDFSRGTLHCKEGYCAYRASSASQLLFNHNTMTDFHPYNWTMLMTGVFLLVYGLVVWSKITSHVINAGYALNVATLIYTTYATVLSYYHWDNPPYKVFSPFSFTGVLHSFFGPILLHMTTLCLLVQAIINVPGVYVHGIHYYPEIALDPTASEHTKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A268</accession>
    <name>A0A075A268_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162877.1">
        <property type="nucleotide sequence ID" value="XM_009164613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A268"/>
    <dbReference type="STRING" id="6198.A0A075A268"/>
    <dbReference type="GeneID" id="20314952"/>
    <dbReference type="KEGG" id="ovi:T265_00764"/>
    <dbReference type="CTD" id="20314952"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="757" mass="84470" checksum="8A146C71157F86ED" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A278</accession>
    <name>A0A075A278_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596962">
        <property type="protein sequence ID" value="KER21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174755.1">
        <property type="nucleotide sequence ID" value="XM_009176491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A278"/>
    <dbReference type="GeneID" id="20324360"/>
    <dbReference type="KEGG" id="ovi:T265_10192"/>
    <dbReference type="CTD" id="20324360"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12715" checksum="F26815EEF96D64C9" modified="2014-10-01" version="1">MNGARWVKWLEHEFTDRKVRGSNPTSASRLPLSRLGQTGSIPALVPPSCDMAARHRKGLVFTRDSTEPLVYDSLQPNVLHTGRLLIQLALYSRYRACVQHIQLWDIINEGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2G8</accession>
    <name>A0A075A2G8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC-50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162755.1">
        <property type="nucleotide sequence ID" value="XM_009164491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2G8"/>
    <dbReference type="STRING" id="6198.A0A075A2G8"/>
    <dbReference type="GeneID" id="20314851"/>
    <dbReference type="KEGG" id="ovi:T265_00663"/>
    <dbReference type="CTD" id="20314851"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47717" checksum="8FA48AF9C2D8697F" modified="2014-10-01" version="1">MRDCECRADTPHYSSMGRRVTQTATPVSMWRAAPRTALNHDPPMSSVHINVTDSLPRSVCTKMLTCSQPCHPGSMHRILSAAEKRSRYFRRLLKFKHMDFEYAFWQMAQLIFTPQRLFRNFQYRNCMSFIWQQAIYCLVGSRRQWARDDPAFLVLVFTMFLVSSIIFATFTLHTLELRIKFVLWVAFFDFFAMALLAATFFWIVTNRILIDRSGRFSSDLLSEVPDTQSNQDVEWAYAFDIHLNAVFPAALVYLLQLPLFYFILSDGLAGRFVGNTCWLIAALYYNYITFLGYSALPFLKRATVLLWPMTASVLLFIIATFVLQWNFTNPHTPIAQRLTVTVASAWYECRNHRGISLTPVVTGLLESIVLRCITVAREILTREQQAEFRSDKGCVDQIFTLRQVLEQRHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2W5</accession>
    <name>A0A075A2W5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166293.1">
        <property type="nucleotide sequence ID" value="XM_009168029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2W5"/>
    <dbReference type="STRING" id="6198.A0A075A2W5"/>
    <dbReference type="GeneID" id="20317704"/>
    <dbReference type="KEGG" id="ovi:T265_03517"/>
    <dbReference type="CTD" id="20317704"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="29556" checksum="ECB8C64E127B30A7" modified="2014-10-01" version="1">MPIGHKARLSLESWNLLNDNIKQQSLALSVDFPRKCRGAVDLDRWKASELRQFLLYIGPVVLRDILHPDVYECFMLFTFFSQHYANFLIDVSKVAVCKFTAIFGPSHLVYNIHLFFHLFNFVKLYGCLDRFSCFPYESELGHLKHYMRGPKPSAVQLYCRLSKHVGLDVVERKGCRFFENFPDNCILLDGQPAVIVDFSKDTMVYQKFKTVLPFYTHVLISTDILVFQCSDLQHTRLFASVDHLVYSSKMTMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3R2</accession>
    <name>A0A075A3R2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162077.1">
        <property type="nucleotide sequence ID" value="XM_009163813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3R2"/>
    <dbReference type="STRING" id="6198.A0A075A3R2"/>
    <dbReference type="GeneID" id="20314344"/>
    <dbReference type="KEGG" id="ovi:T265_00156"/>
    <dbReference type="CTD" id="20314344"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="38033" checksum="8159CE8ED3DF59EE" modified="2014-10-01" version="1">MDLSRITAPFAMITTPDFHTLKVEWFDSLEELEMLGLKCAVEVSIRKTDHSNWEVIYLGRSDQCVYSKMEPGMEYMVRLRLNMGDKFGPYGEEQPIEMPPEPNTGSDLHKAIKFEDMDQLRSILSVGQVDLEVADQFDFTPLMAVANRNLRNFVTVLIKYGAKVNTTNKLGKTALMIAANKGFIEIAECLLQNGADPNLQDINGMHAVFYAVDGENGNMIRLLHKWGAHINLEDRDNQWTPLIRLACLANNGNPRVGSALIDCGADVNHRDKYGQTALIHCAFHRNHTDLAKLLLSCGADPDIRNKKNHTAWDIAKSLENLNFCQLVEKFKRSVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A467</accession>
    <name>A0A075A467_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596915">
        <property type="protein sequence ID" value="KER22159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174080.1">
        <property type="nucleotide sequence ID" value="XM_009175816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A467"/>
    <dbReference type="GeneID" id="20323835"/>
    <dbReference type="KEGG" id="ovi:T265_09667"/>
    <dbReference type="CTD" id="20323835"/>
    <dbReference type="OrthoDB" id="10043502at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57611" checksum="CC43DD146C493A4F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Z4</accession>
    <name>A0A075A4Z4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162802.1">
        <property type="nucleotide sequence ID" value="XM_009164538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Z4"/>
    <dbReference type="GeneID" id="20314877"/>
    <dbReference type="KEGG" id="ovi:T265_00689"/>
    <dbReference type="CTD" id="20314877"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="8165" checksum="01D49623D77DFAD7" modified="2014-10-01" version="1">MRLIRRIFCSGAVRIRSTERLDPTCRCTYTVLCRIPYGAYVRPLLEYANQVVYSGRTKDVTLIERSLNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7X0</accession>
    <name>A0A075A7X0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164478.1">
        <property type="nucleotide sequence ID" value="XM_009166214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7X0"/>
    <dbReference type="STRING" id="6198.A0A075A7X0"/>
    <dbReference type="GeneID" id="20327074"/>
    <dbReference type="KEGG" id="ovi:T265_12906"/>
    <dbReference type="CTD" id="20327074"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="62497" checksum="845C2E1BC4E1BE85" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A905</accession>
    <name>A0A075A905_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164144.1">
        <property type="nucleotide sequence ID" value="XM_009165880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A905"/>
    <dbReference type="GeneID" id="20315978"/>
    <dbReference type="KEGG" id="ovi:T265_01790"/>
    <dbReference type="CTD" id="20315978"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="8779" checksum="9B949847644F111F" modified="2014-10-01" version="1">MFLAPSRSATAQARSALAAEKAIQFTLKRYYFIVFDSIKSIANSVLLVPISLSHRRCTPAPESLQTTAVLSDQGKIKHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB34</accession>
    <name>A0A075AB34_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171444.1">
        <property type="nucleotide sequence ID" value="XM_009173180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB34"/>
    <dbReference type="STRING" id="6198.A0A075AB34"/>
    <dbReference type="GeneID" id="20328498"/>
    <dbReference type="KEGG" id="ovi:T265_14332"/>
    <dbReference type="CTD" id="20328498"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="16759" checksum="76E2F5C2FF1E19BC" modified="2014-10-01" version="1" fragment="single">SDNFDYAETIGFRRWLKWLEREFTDRKVRGSNPTSATRLPLSRLGQPDSIPALVLPSGGMAARHRKGATVERCALSISDPHQGRAVDLSPCGDEIARWLNRPLTDRKVCVSNTTSASRLSRFGQPEITAALVHPGVAASHRNGWTAKRKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACX9</accession>
    <name>A0A075ACX9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 72 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170523.1">
        <property type="nucleotide sequence ID" value="XM_009172259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACX9"/>
    <dbReference type="STRING" id="6198.A0A075ACX9"/>
    <dbReference type="GeneID" id="20321050"/>
    <dbReference type="KEGG" id="ovi:T265_06871"/>
    <dbReference type="CTD" id="20321050"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="32255" checksum="DA0F5EB5A37D6088" modified="2014-10-01" version="1">MSYASNTEPKRSKPTESSKSTAQQIDEQTEPKPKSTIKEKATGSTEGEVATFESRVLRQRTVPSTSESTGTESKSRRNDSTALRRQAMLAEIAQRKNVPEVRRLTQEELLAEAKLTEEINRRSLARYQRMEIEKKKVHFQKSKSTVPMIRYHSFTVPLVEDQPHLYGVSVDPQSSTVRAGPIITDPSARCSRNLITFADEQCLRASMPKTITPLPDPNNPAPVAPRPRRIMRICPITGLPARYLDPVTLTPYANLAAFRVLRRLYQLHLETNTPAIDLLREYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD44</accession>
    <name>A0A075AD44_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trematode Eggshell Synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170434.1">
        <property type="nucleotide sequence ID" value="XM_009172170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD44"/>
    <dbReference type="GeneID" id="20320984"/>
    <dbReference type="KEGG" id="ovi:T265_06805"/>
    <dbReference type="CTD" id="20320984"/>
    <dbReference type="OrthoDB" id="6243337at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32727" checksum="D027D3F5BFBE833F" modified="2014-10-01" version="1">MALAAMIAKPVVGRRGVFSNLMSSALQYNGGVFVISVELLIMKRPVAKATDLSSIPEVPATLVDGYGRGQRAKVGRFYRGAYEDATGADVSSYDYNLRGGLSAHGDSVYDGTSVEHDQEAEAGYYTQGGSFFTHGKAEDNTDHGLDSYLKAKGKFYGTGYEDESSEYQTVTKFRSGGAQNGYSKKKHYNQYESYGQAKKTGDKKLKSNFDLYGKLKAQGKFNGYGKSDIFSKFDKYAEYGQEGKTKGTADKDVYGKLKGRSKYDAYGKLSGYGSGNDYSKYGSHGDYDKLGNLGEYYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADD0</accession>
    <name>A0A075ADD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161933.1">
        <property type="nucleotide sequence ID" value="XM_009163669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADD0"/>
    <dbReference type="GeneID" id="20314200"/>
    <dbReference type="KEGG" id="ovi:T265_00012"/>
    <dbReference type="CTD" id="20314200"/>
    <dbReference type="OrthoDB" id="6250137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="482" mass="52817" checksum="0AE6C84AD7E0D857" modified="2014-10-01" version="1">MREIVSASSVYKGPQRMESEMETRELVIVQPESPLEFEKSPHDTEPTSSSNFGTTCIGIKTIQQNTHSQNDPSTGIPSIGGQMSTEQELETNGSVITDKFQDGKLSENFGEQTERKHFSEREITYNLVLRKLVDGFMDRSVTYSHQPKSLLHTLCSTLARNFPELGDAYHRERICAYLKACRRNAKKKHGEPYVRMSARYLSAGTAARLAEEIYLKEKDYLLNGQRSLEDSVSYQFHTPPNSTERGEIEASKPSDEATSINGGTPVTLQSLNTPSLCFQSPLDSVSPILIPLPSSVPMASLPAIVATTPLIRREVELNEVTAPGCDEADGTSRPLSESSKQPYMQCVPLGEFVMLTKLAEAVISKSLFKPRHPICLAAFSVRTLKKAGQQAALALTLDSLGIGVCCVPGTRIQHTSSVTELTATPVSIRFRLRTSGDPEVSVAGCAGVGTVISHRAEVSLLDWIPVDSHLCEVRLVTSVKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADU5</accession>
    <name>A0A075ADU5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169929.1">
        <property type="nucleotide sequence ID" value="XM_009171665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADU5"/>
    <dbReference type="GeneID" id="20320586"/>
    <dbReference type="KEGG" id="ovi:T265_06407"/>
    <dbReference type="CTD" id="20320586"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10291" checksum="9858D26E2B438FF6" modified="2014-10-01" version="1">MCPQASPAHAPHKRLRTISAHSLATSSMAGKQDEVADSLSDVASCGGSNSQGSVLGPELFELHVNYLKGLEILSSTYAGGLGLVATSDVNHFRNDPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGT0</accession>
    <name>A0A075AGT0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167175.1">
        <property type="nucleotide sequence ID" value="XM_009168911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGT0"/>
    <dbReference type="STRING" id="6198.A0A075AGT0"/>
    <dbReference type="GeneID" id="20318404"/>
    <dbReference type="KEGG" id="ovi:T265_04218"/>
    <dbReference type="CTD" id="20318404"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="272" mass="29403" checksum="D813A3B534FB46CC" modified="2014-10-01" version="1">MIPELHVWTAAVERSACTLAVAPFQCLAAMLPEGSTRAGIMPGCPSLDRGGRIRTTDLPVSKFALHLLGPPRPLNNIGSCFLMLHCGRPQLSSCPDVSDLTVSQLPMNRTYTNKLRPHQPSRSAVSRVALLAAYSRVGKRKQFSSKTSLLSLSHTFTSNICASSGADSLRHFEINVQTSASCPSECFQSSHSETSGTTSCSCSHTEFAWNRLSYVSESIIQDVITAAAAGCGEFGIILSHQIEGYVLDYIRVDSRLYAVRLATSLKVSQVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH97</accession>
    <name>A0A075AH97_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166736.1">
        <property type="nucleotide sequence ID" value="XM_009168472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH97"/>
    <dbReference type="GeneID" id="20318067"/>
    <dbReference type="KEGG" id="ovi:T265_03880"/>
    <dbReference type="CTD" id="20318067"/>
    <dbReference type="OrthoDB" id="5814089at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="57181" checksum="3B87DF7A5A2E9CE6" modified="2014-10-01" version="1">MGMITTVNLEPGLCFGPLPTDWMIADPAYLIAQTTTDQLPELPTVIVNPLQLSDPHRLIEWVCNLRSARYPGEQNVELIRDPTTGHSFYYIIRPIDAGQEMFVWFRRADINPLAERVLKQRLAVDAWLGLDEASDMTQAACDQTPGRVSASMQCELCNAEFRFIYPYIAHFLFKCGGHKLIREIQVHLDGQTSSHPNLLPRDTVCGHQPVIKPSDGNSPSLSWKLKTHLRLPETIKDVVRVPPVDVPGLSLIQNSSSSWYPQPNLPPEHQAGPVDGESVSATNSRMKNKAYEKPPRPIPKPNSVRCFGEQKTQRRLEANKLQKQLCGQYQNSQRNRKASCYPASSYPHKDSPFASRTRNPLVEQLLQTIIHRLNQPAAGKTALPLPSTSLRLAQNWCARCFTTFRLTSDLVQHMRTCHNKEQTGMRIRAPPPERCASGQPVAEENRRESMSTVDTYNSKATQQEQPPEARSRLEVADLTRTSLVCHLCGETFRERHHLTRHMTSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHE0</accession>
    <name>A0A075AHE0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin repeat and MYND domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166545.1">
        <property type="nucleotide sequence ID" value="XM_009168281.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AHE0"/>
    <dbReference type="GeneID" id="20317921"/>
    <dbReference type="KEGG" id="ovi:T265_03734"/>
    <dbReference type="CTD" id="20317921"/>
    <dbReference type="OrthoDB" id="48314at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053064">
        <property type="entry name" value="Ankyrin-MYND_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15897">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15897:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="835"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="899"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1078"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1382" mass="154795" checksum="6909DBC02F3B045F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI43</accession>
    <name>A0A075AI43_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165230.1">
        <property type="nucleotide sequence ID" value="XM_009166966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI43"/>
    <dbReference type="GeneID" id="20316852"/>
    <dbReference type="KEGG" id="ovi:T265_02664"/>
    <dbReference type="CTD" id="20316852"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="18314" checksum="3CE070BA1F8D4BC0" modified="2014-10-01" version="1">MTYYLDILPGHHICFLISARQTKCFDHRNGQSSCLPDVTKLKTSVKDQWDIQPNGLKSTDNCIVSLGTNQRKIQIVRKPSNEKCFPQPISASFSVVVSLCCFSLQQLSFDLQRSSDYKNFSANGLKDVIKAMDLNRFLIHKLSMYLSAFCNFEIPFPKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI57</accession>
    <name>A0A075AI57_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165180.1">
        <property type="nucleotide sequence ID" value="XM_009166916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI57"/>
    <dbReference type="GeneID" id="20316806"/>
    <dbReference type="KEGG" id="ovi:T265_02618"/>
    <dbReference type="CTD" id="20316806"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="7999" checksum="387640C6929AECC0" modified="2014-10-01" version="1">MNRTGLSIIFFTHLQGVEVILIGLLVQGSYRPIIYPQLEEVHSAKDEEKANVPSLDLGASHLAGKKGSDQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJC5</accession>
    <name>A0A075AJC5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutathione transferase</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="function">
        <text evidence="1">GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163006.1">
        <property type="nucleotide sequence ID" value="XM_009164742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJC5"/>
    <dbReference type="STRING" id="6198.A0A075AJC5"/>
    <dbReference type="GeneID" id="20315035"/>
    <dbReference type="KEGG" id="ovi:T265_00847"/>
    <dbReference type="CTD" id="20315035"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="24292" checksum="A4847773D2722383" modified="2014-10-01" version="1">MADEHYTLFYFHFRARAEAIRMILHANGVHFEDVRFGMNEWPERRNQIPGSRVPLLQVKKAKEVVNYVESMAIARMLAKRFNMMGDSEEEYYNVERMIGECADLDKEFYTAFFAPPDQKEEMLKKSMSEAVPKMLDLISKSISESGGKFVAGDKVTLGDICLLTSMDHVRKHDPEFLGKHYPKLLALEQEVLKAKPKLAEYIRTRPETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJW6</accession>
    <name>A0A075AJW6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00271</name>
        <name evidence="6" type="ORF">T265_00274</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162243.1">
        <property type="nucleotide sequence ID" value="XM_009163979.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162246.1">
        <property type="nucleotide sequence ID" value="XM_009163982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJW6"/>
    <dbReference type="STRING" id="6198.A0A075AJW6"/>
    <dbReference type="GeneID" id="20314459"/>
    <dbReference type="GeneID" id="20314462"/>
    <dbReference type="KEGG" id="ovi:T265_00271"/>
    <dbReference type="KEGG" id="ovi:T265_00274"/>
    <dbReference type="CTD" id="20314459"/>
    <dbReference type="CTD" id="20314462"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="18591" checksum="DF9A1C4BAB5EEAF2" modified="2014-10-01" version="1">MDSSVLIKPDPHSTQSHPPKITTNQLEYIKKEVVGRLLKEKSVRPFTQPVDYERPNLPDYPRIVKHPMDLSTMKQRLNLKFYHSSSKCLDAIFTMFRNCYIFNKPGDDVVAMAMKLEQLARERLKSVPSPETEICPQKNSKSTKPVPSLRSTDDPLHNRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU97</accession>
    <name>A0A074YU97_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL602266">
        <property type="protein sequence ID" value="KER18371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177882.1">
        <property type="nucleotide sequence ID" value="XM_009179618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU97"/>
    <dbReference type="GeneID" id="20326460"/>
    <dbReference type="KEGG" id="ovi:T265_12292"/>
    <dbReference type="CTD" id="20326460"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8496" checksum="977DA8016EEC878C" modified="2014-10-01" version="1">MNEYKSGSPRITICSGGEFYKRTDGHGSQDVRDNSSFKVDRKTKAGVPKERAHKQSRILKERLLLLLSSSLLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUA9</accession>
    <name>A0A074YUA9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604035">
        <property type="protein sequence ID" value="KER18298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177955.1">
        <property type="nucleotide sequence ID" value="XM_009179691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUA9"/>
    <dbReference type="STRING" id="6198.A0A074YUA9"/>
    <dbReference type="GeneID" id="20330315"/>
    <dbReference type="KEGG" id="ovi:T265_16150"/>
    <dbReference type="CTD" id="20330315"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14425" checksum="F1F87885B95397CF" modified="2014-10-01" version="1" fragment="single">SLTVSIFPSIPSDIQPSSCGTSSPRSSRLSVSSQQSRHSPVTSGLAGLDYGFATTDSKRHQAAKASYMSPIADRIRNLRSGDSKTSFQTNNVVLISVRPRKLETNHEQVVDKLANMMAERAHMKSPNLEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUG9</accession>
    <name>A0A074YUG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL602556">
        <property type="protein sequence ID" value="KER18353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177900.1">
        <property type="nucleotide sequence ID" value="XM_009179636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUG9"/>
    <dbReference type="STRING" id="6198.A0A074YUG9"/>
    <dbReference type="GeneID" id="20330282"/>
    <dbReference type="KEGG" id="ovi:T265_16117"/>
    <dbReference type="CTD" id="20330282"/>
    <dbReference type="OrthoDB" id="10023951at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF31">
        <property type="entry name" value="LD44824P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="195" mass="21771" checksum="F5CD934538BF6D29" modified="2014-10-01" version="1" fragment="single">GQLAGTHESVIENGSKAVNGTSHLTEKDDFPTEQRTEESENKSVAAVPQSPIIDGHYYLRQAAHSEAELLGLIDRAEFDLSDKALDEESSGLLRTAIGKARLLIAEKFAQFRGLCQLNLEWNQQTAPSDPDVKHLFTSLEDLDGFWAIVRLQIDDVHRLFDQIERLRSNNWRTPNEVDSNSLASGQKKTAKNNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW49</accession>
    <name>A0A074YW49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597391">
        <property type="protein sequence ID" value="KER19001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177252.1">
        <property type="nucleotide sequence ID" value="XM_009178988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW49"/>
    <dbReference type="STRING" id="6198.A0A074YW49"/>
    <dbReference type="GeneID" id="20326229"/>
    <dbReference type="KEGG" id="ovi:T265_12061"/>
    <dbReference type="CTD" id="20326229"/>
    <dbReference type="OrthoDB" id="10055895at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF16">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="453"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117854" checksum="354CEE6AB395268A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXJ9</accession>
    <name>A0A074YXJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Malectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_11724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597185">
        <property type="protein sequence ID" value="KER19526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176723.1">
        <property type="nucleotide sequence ID" value="XM_009178459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXJ9"/>
    <dbReference type="STRING" id="6198.A0A074YXJ9"/>
    <dbReference type="GeneID" id="20325892"/>
    <dbReference type="KEGG" id="ovi:T265_11724"/>
    <dbReference type="CTD" id="20325892"/>
    <dbReference type="OrthoDB" id="10013439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703651" description="Malectin domain-containing protein" evidence="12">
        <location>
            <begin position="24"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="13">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER19526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="267" mass="30182" checksum="5537375E645F57B9" modified="2014-10-01" version="1">MDCTLWNTGFCIFLLTATPLTWAEVVWAVNCGGPAHIDVHGIEYIADPLLQGTASEYGRQLVINRVRMEDQILFQTERFHTDHFSYDLPHLGDGSYVLTLGFSEVWFAEPNQKVFDVQLNKEITLLQDLDIFNEVGFATGLVYDFPFRIADGVLHVGESSTPISRDSITLNFLRTGRDNPKINMIRIIRGTLKDLRAIVPSDLVSAPEPKEQHHIPKYEPEPQPRKRPAGSPRVPDPYENTDSSYWLLPILGSVAAFLPILFCLCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6268343at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
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            <end position="323"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER20101.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZZ8"/>
    <dbReference type="GeneID" id="20325341"/>
    <dbReference type="KEGG" id="ovi:T265_11173"/>
    <dbReference type="CTD" id="20325341"/>
    <dbReference type="OrthoDB" id="6241791at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="274"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57083" checksum="39BB5E06175C07B1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0J7</accession>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13118" checksum="16A793CA69F341B5" modified="2014-10-01" version="1">MDDHLKVLVASPSVSLCVQPVPPNNGGAVQCDASLESRCPVVPSRMSATVCQTPTFVMNPSVFAQGLFGLTTTANVFHSVWRDHALHIQRVVEMRLFGRRRENGGLTDDLRFGLQEIVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A074Z0K7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009177502.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20325141"/>
    <dbReference type="KEGG" id="ovi:T265_10973"/>
    <dbReference type="CTD" id="20325141"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="130" mass="15202" checksum="70BC25D396AE656F" modified="2014-10-01" version="1">MVPRKQTTSQRHPDEYYLIEQKRKQFGLFPPKYKVQHQLASLQKLRSIYDQEKRIQPSVAMTNYHCLLTSKHSPLKSLSSIELRKNNTRVQYIMSFDGDATKKGSPKDRPSPPVGQTRMNKLRVELRCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z262</accession>
    <name>A0A074Z262_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175117.1">
        <property type="nucleotide sequence ID" value="XM_009176853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z262"/>
    <dbReference type="GeneID" id="20324641"/>
    <dbReference type="KEGG" id="ovi:T265_10473"/>
    <dbReference type="CTD" id="20324641"/>
    <dbReference type="OrthoDB" id="10047254at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17315" checksum="A35973FBFB05C881" modified="2014-10-01" version="1">MVDPYVISRPSHGNGQVERLSGTLWNAIQLDRASKYEPVVEEVELINCNPHYARVRFPGGKESTASVRHLAPCGDRTHVNDFTRTSSNEDNGVHAPPLSDLHTPPLNNIGDDIDHTSVSPPCPGNAPASPDTYDPSISDLARLQQRTRPYILRNREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2F7</accession>
    <name>A0A074Z2F7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597158">
        <property type="protein sequence ID" value="KER19672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176585.1">
        <property type="nucleotide sequence ID" value="XM_009178321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2F7"/>
    <dbReference type="GeneID" id="20325788"/>
    <dbReference type="KEGG" id="ovi:T265_11620"/>
    <dbReference type="CTD" id="20325788"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16867" checksum="57118A40AE768441" modified="2014-10-01" version="1">MCSHLITEHLEVTLEDYHAKLELCSNNTTVACLIQRGSYHQMNSKLSGTPALRKFLDIPDQETMTEASSLFRGRNPKNVPRFRKELLFRVQYPDQSETNAGLSDSAMENWFLFGGSLLSCGIHCTNKIEAPGVEQRVKRVSYLAYLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Q8</accession>
    <name>A0A074Z3Q8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596946">
        <property type="protein sequence ID" value="KER21711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174551.1">
        <property type="nucleotide sequence ID" value="XM_009176287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Q8"/>
    <dbReference type="GeneID" id="20329195"/>
    <dbReference type="KEGG" id="ovi:T265_15029"/>
    <dbReference type="CTD" id="20329195"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7115" checksum="B3E1988F31AE7340" modified="2014-10-01" version="1" fragment="single">MFDVGLARRFSGSQSDTDQFYRQMEAKNPTEIAMQEFGSARQHAGVASRSEATLFEDLRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4Q3</accession>
    <name>A0A074Z4Q3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604432">
        <property type="protein sequence ID" value="KER18285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177968.1">
        <property type="nucleotide sequence ID" value="XM_009179704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4Q3"/>
    <dbReference type="STRING" id="6198.A0A074Z4Q3"/>
    <dbReference type="GeneID" id="20330327"/>
    <dbReference type="KEGG" id="ovi:T265_16162"/>
    <dbReference type="CTD" id="20330327"/>
    <dbReference type="OrthoDB" id="6226968at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="6859" checksum="531D5069144F6F34" modified="2014-10-01" version="1" fragment="single">MSAVTISSAPFSSDAEALIAAPRILSSIEGLTEVPEGEPVHLELRVSPPGDLQVQWYKDGHSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z503</accession>
    <name>A0A074Z503_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175631.1">
        <property type="nucleotide sequence ID" value="XM_009177367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z503"/>
    <dbReference type="STRING" id="6198.A0A074Z503"/>
    <dbReference type="GeneID" id="20325041"/>
    <dbReference type="KEGG" id="ovi:T265_10873"/>
    <dbReference type="CTD" id="20325041"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7234" checksum="DAA6B669EFD9EC26" modified="2014-10-01" version="1">MNPKMSGRSAATCLGLRRLFAILDTNGDGKIDLQELTDGLRIFGFKPAGIQVDVANFVLLNTPKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5U9</accession>
    <name>A0A074Z5U9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173801.1">
        <property type="nucleotide sequence ID" value="XM_009175537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5U9"/>
    <dbReference type="GeneID" id="20323631"/>
    <dbReference type="KEGG" id="ovi:T265_09462"/>
    <dbReference type="CTD" id="20323631"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8801" checksum="BEB15E6436812660" modified="2014-10-01" version="1">MDNSSFLLWRTDLVINNEKGNVQCSRAKRMKKPPFSPMYGTRNTANLIDQSSEGQPPHARRPHGGLAMVYGNKKNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6F7</accession>
    <name>A0A074Z6F7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lecithin:cholesterol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596882">
        <property type="protein sequence ID" value="KER22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173508.1">
        <property type="nucleotide sequence ID" value="XM_009175244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6F7"/>
    <dbReference type="STRING" id="6198.A0A074Z6F7"/>
    <dbReference type="GeneID" id="20323404"/>
    <dbReference type="KEGG" id="ovi:T265_09225"/>
    <dbReference type="CTD" id="20323404"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52131" checksum="21341247E723A63E" modified="2014-10-01" version="1">MTQSSLTLPDSLSFTSQFVKVAHPSLGAYPLACNLSQSLTLLMFLLLVVCLILLHSPYYVIAETQSPIVLVPGDGGSQAYCSPTGSVESFLLWVNLRYFITPGTLAQYFSIIYDPRTGEIHDSDLCNVTFPGWGDTWSIENLDTYKHSGTVYFEHLVTSLRQDPFYVSNRTLRGTPFDFRRAPNENPDFQQRLRLLIEETYIIAGSRRVVLLGHSLGSLYCLAFLHAQSNDWKRKYIKAFLSVSGPLGGSVKALKLEVSGDNFGVLIRSPLSFREVQRSLPSTAFLMPDPRLWPPSEPIIITPKLNYSAHDYQKLFSDINFPQGYAFLQNTKPSVDGFMGPTGLDEVYCIHGSKVSTTYQLVYPEPSFFHKGFPDEYPTLITGDGDGTVHLRSLQLCRLWPGAKYIVLEGAEHLHIVGDERFLKLIHEIAGVQQSHCRRRKHNTRIPQSNGKLTRTTHLTIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Q3</accession>
    <name>A0A074Z6Q3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596882">
        <property type="protein sequence ID" value="KER22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173512.1">
        <property type="nucleotide sequence ID" value="XM_009175248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Q3"/>
    <dbReference type="GeneID" id="20323408"/>
    <dbReference type="KEGG" id="ovi:T265_09229"/>
    <dbReference type="CTD" id="20323408"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="342" mass="39000" checksum="CF458647D700BD7F" modified="2014-10-01" version="1">MSPNWKGETGRGLSESFQQPYLCRERCAPVKKVHRISAVKKHPLALQLETNGLEREFADQKVRGLNPTSASQHPLSRLEQPGSISALVLPSGDTVARHQKGVAAKRFLYKSVFIKETTHTVAESPSAVQGRFRPSLGSEFPSTLCSTGTQIGPTATNTLSCKSILFSREKRLSYFFQLVQPNVANFSRYFLLTEVVDVRPETKNLTYKIRSKFCNFPPKHNPLLICMNTNRFILAYSISFSKKLFILRHSSIISHDICFVGYYYIVFTDSVRRFGDYQQRFLTKETTHRVAENSLTAHYRFRPSCGSSGRRSRRVSVNLMFYLNPNWTDCFRQILSLANQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7K9</accession>
    <name>A0A074Z7K9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calreticulin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_15627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597298">
        <property type="protein sequence ID" value="KER19185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177069.1">
        <property type="nucleotide sequence ID" value="XM_009178805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7K9"/>
    <dbReference type="STRING" id="6198.A0A074Z7K9"/>
    <dbReference type="GeneID" id="20329792"/>
    <dbReference type="KEGG" id="ovi:T265_15627"/>
    <dbReference type="CTD" id="20329792"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703995" description="Calreticulin family protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="484"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67350" checksum="20E3D090FE91C577" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8F9</accession>
    <name>A0A074Z8F9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C2 calpain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596847">
        <property type="protein sequence ID" value="KER23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172749.1">
        <property type="nucleotide sequence ID" value="XM_009174485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8F9"/>
    <dbReference type="STRING" id="6198.A0A074Z8F9"/>
    <dbReference type="GeneID" id="20322802"/>
    <dbReference type="KEGG" id="ovi:T265_08623"/>
    <dbReference type="CTD" id="20322802"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C2 calpain" evidence="5">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="29015" checksum="09826418A3231A2C" modified="2014-10-01" version="1">MDAQVGQLSAEAVRFGVNAPRTANGDLLLQLCADPQSYATNPQFQFDVPENENEDHELVVISLLLCDFRKRSPPKIRQIGFRIYSLTQPHNSPLSAVELTSLPTVYNTECQSRATVTVLLQLIQGSYLIVPSTEEPNQRGDFKIRLVSLFKASIWELDRPNKQLEISAEQEMMTPSVVQSDHNIRTCIRKFDRHCDKESFTLDAAQLRKLFRENHPKGKFKVFKFPLVEILSYMFVCKHLATRGIIFCTLEVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8S0</accession>
    <name>A0A074Z8S0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596846">
        <property type="protein sequence ID" value="KER23528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172741.1">
        <property type="nucleotide sequence ID" value="XM_009174477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8S0"/>
    <dbReference type="STRING" id="6198.A0A074Z8S0"/>
    <dbReference type="GeneID" id="20328795"/>
    <dbReference type="KEGG" id="ovi:T265_14629"/>
    <dbReference type="CTD" id="20328795"/>
    <dbReference type="OrthoDB" id="10013157at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042651">
        <property type="entry name" value="Rgs22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583:SF2">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="628" mass="72536" checksum="1B7C28FB4F80AF8D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z955</accession>
    <name>A0A074Z955_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596919">
        <property type="protein sequence ID" value="KER22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174152.1">
        <property type="nucleotide sequence ID" value="XM_009175888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z955"/>
    <dbReference type="GeneID" id="20323893"/>
    <dbReference type="KEGG" id="ovi:T265_09725"/>
    <dbReference type="CTD" id="20323893"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11861" checksum="B27CB14D4B3CAA7B" modified="2014-10-01" version="1">MANIHGCFEHASLCFSHQTTSRTPEDPMCCMSEWDGGNEPAASILIVFTLNRPQRSHMESVALKYLPSLYNLKQYIIGNKNFPVRCLMARQVARFEAICSSEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9I4</accession>
    <name>A0A074Z9I4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ligand-gated ion channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_08425</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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        <location>
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        <location>
            <begin position="683"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="869"/>
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    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="470"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
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            <begin position="481"/>
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        <location>
            <position position="562"/>
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        <ligand>
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        <location>
            <position position="567"/>
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        <ligand>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
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        <source>
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    <sequence length="1067" mass="119214" checksum="7CB6B5C8FFBE5497" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Opisthorchis viverrini</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
            <begin position="500"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
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        <location>
            <begin position="131"/>
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        <location>
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        <location>
            <begin position="69"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="74996" checksum="2B27E2EA2275D7C4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBR3</accession>
    <name>A0A074ZBR3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171522.1">
        <property type="nucleotide sequence ID" value="XM_009173258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBR3"/>
    <dbReference type="GeneID" id="20321858"/>
    <dbReference type="KEGG" id="ovi:T265_07679"/>
    <dbReference type="CTD" id="20321858"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16313" checksum="002056186859626F" modified="2014-10-01" version="1">MPPTADPQSGESGQYMIHNKLGMNLTNMRITAPGQKEDCSNESGVKVWVGPIIPLKMTAILSQCVSLTPSSSSPRTRNGKELADELWNQHILSPHPGTERKLIPGPWRRAGREKYVKENERVVSTNLLRLSALLCAAIKATRSMAPPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC23</accession>
    <name>A0A074ZC23_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171579.1">
        <property type="nucleotide sequence ID" value="XM_009173315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC23"/>
    <dbReference type="GeneID" id="20321898"/>
    <dbReference type="KEGG" id="ovi:T265_07719"/>
    <dbReference type="CTD" id="20321898"/>
    <dbReference type="OrthoDB" id="6275016at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="327" mass="36006" checksum="1FBE63CFE2F36FAA" modified="2014-10-01" version="1">MSFVCTSIHSAEPNTRNGMALTMDQLHPGSTEMEPPSSASTIRTLRSRSQIVPPPLPPISTSYDLKIPPTPRRTKPSWVIHDMDGTKPTLRISQQVRSERRHDVYVNAAKCPVPDHHGSQPNGRSAVGRLSPPAVWTQLLPYRVSTVPPNLSERLKKSETLPNDVWTYSQSSPQDHSQRAVSGVLSGTKGQQFEDIRSEGPRSPPPRPPMRTTSQIPTSMCVKDHLGATGHASSARKAGVQQKGVSNYQSLADMYGVRESFDNSPVLCRYAQLYSMPFHPKTPTSRGSSCSTTKAQQSPSAVSIHSPLKENRRKSPASYMERLHLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCL3</accession>
    <name>A0A074ZCL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596853">
        <property type="protein sequence ID" value="KER23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172915.1">
        <property type="nucleotide sequence ID" value="XM_009174651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCL3"/>
    <dbReference type="STRING" id="6198.A0A074ZCL3"/>
    <dbReference type="GeneID" id="20322941"/>
    <dbReference type="KEGG" id="ovi:T265_08762"/>
    <dbReference type="CTD" id="20322941"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="138" mass="15653" checksum="BADAFB03266C2107" modified="2014-10-01" version="1">MPLKRINKALQNLGCDCFSKRSSGPFVDNFFTLQATVMGIPMMLMREAFLPEDYRPFKPSPPSPKLNLNTKIHQPNTNENGSIQISQVATLSNLLLSIRQLLTNPNLDDPLLPDTALQYNSDRKTVEFAQQWTQKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCR0</accession>
    <name>A0A074ZCR0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172823.1">
        <property type="nucleotide sequence ID" value="XM_009174559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCR0"/>
    <dbReference type="GeneID" id="20322864"/>
    <dbReference type="KEGG" id="ovi:T265_08685"/>
    <dbReference type="CTD" id="20322864"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23318" checksum="11090B74205C8073" modified="2014-10-01" version="1">MFQLMDYETAANGGMTSAARERQMSSACDSSSDCPFGTTVPIGDVPMSKRLGGRLENTFAHCIHYPVSQKLSQDQFQKPELGNTSEGFSCTIQRFLFSRSTQPMNPEPKGQHTNRYKQKKFSDLSCWHIERSQTPVHLIVSPAEALLPSSEHRATLTSSKTMKEQSNRHHGTTALSFTKRQSAVSRLHRQTPQDTSFVGAVVPYEIHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF28</accession>
    <name>A0A074ZF28_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596937">
        <property type="protein sequence ID" value="KER21835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174416.1">
        <property type="nucleotide sequence ID" value="XM_009176152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF28"/>
    <dbReference type="GeneID" id="20324098"/>
    <dbReference type="KEGG" id="ovi:T265_09930"/>
    <dbReference type="CTD" id="20324098"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10440" checksum="30D83F4D554DD812" modified="2014-10-01" version="1">MPGHTIVPIPSSVSLCKPLCDVAVDTNMYFALSGRLRRLSFQDQTSKLPFKADDMFRPSYNKTTTGASDVLSAASVPKWFEVQALEVKGFKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF31</accession>
    <name>A0A074ZF31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172039.1">
        <property type="nucleotide sequence ID" value="XM_009173775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF31"/>
    <dbReference type="GeneID" id="20322259"/>
    <dbReference type="KEGG" id="ovi:T265_08080"/>
    <dbReference type="CTD" id="20322259"/>
    <dbReference type="OrthoDB" id="6232294at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="380" mass="43306" checksum="8768E89D9F8CF3D8" modified="2014-10-01" version="1">MPLRFLRYYSLFGTTSNYSLPFSNISNVSCDLLYNYTSYNRWETLRTDPTIMLYLIINVAGVIGNSLIIALLRKRTLGGRLPTILFRAQSILDLTVNLESIAFGIFSELWNVSSDPLLNLWICHLWHSQFLFWFSVQLSIGNLVLVGMERFLALSFPLLYQRLIPHKVALYWMLTNTIYNLVLASPNILETRIDDGCCVGQKHMDSVRGILRTYAIVWFFMIYLLALILLILFYGGVVLALRQSVVISRAPTRSKVMMRFTRMAIVITFVYITCVSYDAFAYLAGRTGLWSYQYNTVWHRIGMLTVSINSSANPFIYYAFVLRDSCRRNFGLHGCSARSGTNVVNVSQPSPHSNGFRGKPCHASVDSSPSIQPKLKMEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFQ3</accession>
    <name>A0A074ZFQ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174187.1">
        <property type="nucleotide sequence ID" value="XM_009175923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFQ3"/>
    <dbReference type="GeneID" id="20323920"/>
    <dbReference type="KEGG" id="ovi:T265_09752"/>
    <dbReference type="CTD" id="20323920"/>
    <dbReference type="OrthoDB" id="6253943at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704032" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10630" checksum="BEDB61AD94774989" modified="2014-10-01" version="1">MTRILILSSLVIFALVLDNCMARDSKWVTYRGQQSYPGYRQTSPVKTHNKPARPPRPAVPPRADIRGVKLYGPRRNEKEYREGLSELAGLMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG83</accession>
    <name>A0A074ZG83_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-nucleotidase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173973.1">
        <property type="nucleotide sequence ID" value="XM_009175709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG83"/>
    <dbReference type="STRING" id="6198.A0A074ZG83"/>
    <dbReference type="GeneID" id="20323762"/>
    <dbReference type="KEGG" id="ovi:T265_09594"/>
    <dbReference type="CTD" id="20323762"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="303"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66198" checksum="DE6A411517BA2BB1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGQ0</accession>
    <name>A0A074ZGQ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169887.1">
        <property type="nucleotide sequence ID" value="XM_009171623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGQ0"/>
    <dbReference type="STRING" id="6198.A0A074ZGQ0"/>
    <dbReference type="GeneID" id="20328178"/>
    <dbReference type="KEGG" id="ovi:T265_14011"/>
    <dbReference type="CTD" id="20328178"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="1">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20695" checksum="F8E64F8D569D2E99" modified="2014-10-01" version="1" fragment="single">SQGANVLGVDITPCNSFPCTFTIGKQYTVRVGFAATTDIWGGSVVANSIYNGVTKALRLRDPVLCNHLIPPCPVRTGRSYVFSYTGTISWKIPDPIYAEKPRSTVQLFHPYWESSAVRFSRNSEESRTCDLSASSLNTTIKIYLQWQLVNQYTWPFLCIQFPVKFIEEKANSANVPPNHHSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH91</accession>
    <name>A0A074ZH91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596890">
        <property type="protein sequence ID" value="KER22590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173656.1">
        <property type="nucleotide sequence ID" value="XM_009175392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH91"/>
    <dbReference type="STRING" id="6198.A0A074ZH91"/>
    <dbReference type="GeneID" id="20323524"/>
    <dbReference type="KEGG" id="ovi:T265_09351"/>
    <dbReference type="CTD" id="20323524"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23706" checksum="A855379B84A8BA6F" modified="2014-10-01" version="1">MNFFLIKHILFFLNGIYMVLSLILIGLAAYARLSVYITSVSIVGGIIACGVFLFLLSLLGFIGTARHSQAALFFYIVLLFSLFLIQFSVACACLTLSTSDQRTIVEAAWQKSTNATKIDMMRTFQCCGFRRVDLPHDHPMGCPPCHFSELSCCEGDHDRQADCCTVEQKLERGIRVTGTVGLFFSLVELAGVWLALQYRHKRDPSIDPNCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHE3</accession>
    <name>A0A074ZHE3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171119.1">
        <property type="nucleotide sequence ID" value="XM_009172855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHE3"/>
    <dbReference type="GeneID" id="20321535"/>
    <dbReference type="KEGG" id="ovi:T265_07356"/>
    <dbReference type="CTD" id="20321535"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="23755" checksum="767F9DFADFD26C61" modified="2014-10-01" version="1">MILLHLTSASFKLLLQEWVGSNPNLMLADNDEKNGGDKAEYGSDDDGDDDDGGDEHPLRKGFTDTSSYPNISYAFLILKFDSASVRVTHRKKVCRRQRNILKMIDQSYDAVDSCECSTGEMKIIVLSTQDPTNGILQLEQVQRLFSHLSIKFRKTGRLIRRFLFSVFGVAELDSVGLVGGLTAEGSEKDAVSQREYGAEFEDSELKPMDDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHY8</accession>
    <name>A0A074ZHY8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calpain family cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170863.1">
        <property type="nucleotide sequence ID" value="XM_009172599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHY8"/>
    <dbReference type="SMR" id="A0A074ZHY8"/>
    <dbReference type="STRING" id="6198.A0A074ZHY8"/>
    <dbReference type="GeneID" id="20328380"/>
    <dbReference type="KEGG" id="ovi:T265_14214"/>
    <dbReference type="CTD" id="20328380"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16182">
        <property type="entry name" value="EFh_PEF_Group_II_CAPN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
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        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="11">
        <location>
            <begin position="98"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="86131" checksum="032EFE791F10EF72" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI43</accession>
    <name>A0A074ZI43_OPIVI</name>
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        <recommendedName>
            <fullName evidence="1">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">T265_14744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173300.1">
        <property type="nucleotide sequence ID" value="XM_009175036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI43"/>
    <dbReference type="STRING" id="6198.A0A074ZI43"/>
    <dbReference type="GeneID" id="20328910"/>
    <dbReference type="KEGG" id="ovi:T265_14744"/>
    <dbReference type="CTD" id="20328910"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
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    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="587"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="655" mass="72229" checksum="1F1B40BFC9C6DAF7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIP0</accession>
    <name>A0A074ZIP0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173066.1">
        <property type="nucleotide sequence ID" value="XM_009174802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIP0"/>
    <dbReference type="GeneID" id="20323059"/>
    <dbReference type="KEGG" id="ovi:T265_08880"/>
    <dbReference type="CTD" id="20323059"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13225" checksum="B0E0502F8444ED45" modified="2014-10-01" version="1">MFISEGDSYGSNTELQQQSSSKPQEELHPNLVQEGGDTLQHHRTTEEGKKPSIQSILEQWKQSNAIFGRFSGEKMRCDPGNMFISEGDSYGSNTELQQQSSSTGRALSNSNSTNKPPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ93</accession>
    <name>A0A074ZJ93_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172844.1">
        <property type="nucleotide sequence ID" value="XM_009174580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ93"/>
    <dbReference type="GeneID" id="20328811"/>
    <dbReference type="KEGG" id="ovi:T265_14645"/>
    <dbReference type="CTD" id="20328811"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33665" checksum="9B2F2E9FFF2365AB" modified="2014-10-01" version="1" fragment="single">MTWWAEHKFTERKVPGSNPTSNSRPFPSRLGQPGGTPFLVLPPDGMAARHRKGVLELINYQAVCSNQRAFESLVHNSRWLRSSNPTWWLLLRHRFKLAGSQFKKEWKAPSLITPWFPRNWCGFDKQTHLQVDLVSTGDSSESLVYDVIQLNVLHTDHFTFQSKSFQQPCLSNLIVSQPLVLPLGGTAARHRRGARSKMGRRRWGCRDVNCLPDCQLHDPSFPRVRSMLPRMSNYRLWRGLRQNACYLFAELKHPFSVKLPCHLKEARGLGYRQAAWTREVERQRSGSNHGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJP3</accession>
    <name>A0A074ZJP3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169070.1">
        <property type="nucleotide sequence ID" value="XM_009170806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJP3"/>
    <dbReference type="GeneID" id="20319915"/>
    <dbReference type="KEGG" id="ovi:T265_05733"/>
    <dbReference type="CTD" id="20319915"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9748" checksum="564E65F5B8C23FD7" modified="2014-10-01" version="1">MNVPSLIQIDQKYHIISKASDPMRRGHGDNHGEEVVDECIERLEQESSRVWWRRVCGCGWKTRSKGFYARFEDKPNTTRIGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK23</accession>
    <name>A0A074ZK23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172574.1">
        <property type="nucleotide sequence ID" value="XM_009174310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK23"/>
    <dbReference type="GeneID" id="20322675"/>
    <dbReference type="KEGG" id="ovi:T265_08496"/>
    <dbReference type="CTD" id="20322675"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16811" checksum="59882558408A8FF5" modified="2014-10-01" version="1">MSIQKCWKGLPLRQRARWPKWLKREFTDYRVRGSNLTSAFRLPLTMFGRPGSIPALVQPSGGMACKFCWKPFASHAAHDSHRSRQNNHQRCTRSTNAQNEIRNSCTALRIYSVSGYYFLEFLTRSGAPLATGIWPILGHDWLLGPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKW1</accession>
    <name>A0A074ZKW1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168289.1">
        <property type="nucleotide sequence ID" value="XM_009170025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKW1"/>
    <dbReference type="STRING" id="6198.A0A074ZKW1"/>
    <dbReference type="GeneID" id="20319290"/>
    <dbReference type="KEGG" id="ovi:T265_05108"/>
    <dbReference type="CTD" id="20319290"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36984" checksum="6F2796B11012DF57" modified="2014-10-01" version="1">MPPEGSPMTGILPGCQSVDREAGLKSAVARTLDSVCIDACSLSETCIQDLDVPCGVLRRAIEQRRLLDWIPVDNRDCADRLVVSENFDDDHLLEFHQRLTNLNRLDLTGCGWFADRHLLRFLEGTSLTHLDLSHCYRLFGGPPVCSKLASRLKLLSEKLSQLCPNLVHLGVCSVFTLTIEPRDESIQNQSLLTMIVESFPSLHSLNLSENTSLVEYVSWWINANSDSQILLPFFRTFMGSKMSRKGTTMELHLNRWPLACTHAMLIAADSLLTESTSSKFVLHFEHPFLLQDLTSSPKLVLQSSLRTAERKHSLPDKDPALSTAKNSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM19</accession>
    <name>A0A074ZM19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171857.1">
        <property type="nucleotide sequence ID" value="XM_009173593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM19"/>
    <dbReference type="GeneID" id="20328597"/>
    <dbReference type="KEGG" id="ovi:T265_14431"/>
    <dbReference type="CTD" id="20328597"/>
    <dbReference type="OrthoDB" id="10606851at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17099" checksum="BA96907A5CBA543F" modified="2014-10-01" version="1" fragment="single">MTDNMSPVLAKLREIECVLVCQSEGGHYSHICSSRWQQIALFRRFSDVLRADPENADVCLLPRPQRGHLTMLTWTEAQITSTMCPLILCASEFSGPQRNYSTAVTQRFDFPIKPVHRTAFQLVQSVGSRASAEQVTVNHTTVTCNQITTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPF0</accession>
    <name>A0A074ZPF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166947.1">
        <property type="nucleotide sequence ID" value="XM_009168683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPF0"/>
    <dbReference type="STRING" id="6198.A0A074ZPF0"/>
    <dbReference type="GeneID" id="20318234"/>
    <dbReference type="KEGG" id="ovi:T265_04048"/>
    <dbReference type="CTD" id="20318234"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="334" mass="36455" checksum="874953E7988824C5" modified="2014-10-01" version="1">MPVKGVFVSESSETTLSRLFRTTRCFLAEFLGTALICYVSVIYQHGPVPAAFVVGLTLAWIAWVFGPVSGAHVNPVVSLMMLLVRKVWFLDALIYIVAQLLGSMAGSWIGTLAVPAVDAGNTLGMTTISANITVGQAIGLEIVATALLLLVILSAVDELRPKPWNVGNVTIFPFIFGATLALLASLLGDLTGASMNPARSFGPAVVNNNFTDLWVYIVGPFIGALLATVLYEFLLTEGACCNRVKAWFTEADYDRARDYRVPDGNSLNLPSRNTAVIQTKRREHFLITVQKFDVFIFILSDHLPRRLLVSKKSENSLLFYLLTELANTSVVSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPH8</accession>
    <name>A0A074ZPH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168571.1">
        <property type="nucleotide sequence ID" value="XM_009170307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPH8"/>
    <dbReference type="GeneID" id="20319506"/>
    <dbReference type="KEGG" id="ovi:T265_05324"/>
    <dbReference type="CTD" id="20319506"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10788" checksum="9D26CCBE66CD70ED" modified="2014-10-01" version="1">MMLSATTALDEILTTDEILHSNQELWKLSRTPDTVALKMGTTPISFDNRLSLGMFLQESDSQIGFILRRWLLILLSEVNKQAMASARTAYQTLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQU3</accession>
    <name>A0A074ZQU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cation transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_03886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166742.1">
        <property type="nucleotide sequence ID" value="XM_009168478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQU3"/>
    <dbReference type="STRING" id="6198.A0A074ZQU3"/>
    <dbReference type="GeneID" id="20318073"/>
    <dbReference type="KEGG" id="ovi:T265_03886"/>
    <dbReference type="CTD" id="20318073"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022260161" description="Cation transporter family protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="111"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="331"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER29511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="80594" checksum="B6A03707578DBD43" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRD0</accession>
    <name>A0A074ZRD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167856.1">
        <property type="nucleotide sequence ID" value="XM_009169592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRD0"/>
    <dbReference type="STRING" id="6198.A0A074ZRD0"/>
    <dbReference type="GeneID" id="20318949"/>
    <dbReference type="KEGG" id="ovi:T265_04767"/>
    <dbReference type="CTD" id="20318949"/>
    <dbReference type="OrthoDB" id="6243489at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="502" mass="56229" checksum="67BDAB38E9A82E1A" modified="2014-10-01" version="1">MLPFQLHDQLSLIQNAWPELFVINVAQASTPHTPESFRSHNSPELFEATPAGTNNQGLCYNLSPSRKSPCSQEGMDATRSNSKEEIPSTSELVDRFQDQVDRLRMLQLDMAEFVSLKGILLFNAEAPGLCDSATVECIQEKIQSALEEYDRSQFSHTQPFRFGRLLLRLPRLRQVTGEWIKRLFFPHFDKHVSVEQLIREVLYHGPPPVGSNGIDQPTVLDLSSESNTIPVGTLASGLPQCTPEKPEGINYQKTNCHSATAERPLNTSGSSVRSLLYAERKYSDPLRDTRSIPISNDLPYLDQNLTSKNVPLPFPLMYTSLQHPLQRCVEHKFVRSTGHHEKDVDFTVESGLQHHHRSDYQSRPPDPFSTAIRTRTGCNPHFEFKLGIPQDQATCLSTEAVEKALRGSTTTMSPASTDGKNTSLLSKKNNESLQFDSIPFSTPPHITALQLYYAVMRQQLQMLHKRSLPAWSDNVTEAVTSVTSPTTPTVHPNADSSDLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRP6</accession>
    <name>A0A074ZRP6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166477.1">
        <property type="nucleotide sequence ID" value="XM_009168213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRP6"/>
    <dbReference type="GeneID" id="20317858"/>
    <dbReference type="KEGG" id="ovi:T265_03671"/>
    <dbReference type="CTD" id="20317858"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="16840" checksum="7FDA14B7CD6B3357" modified="2014-10-01" version="1">MSKDFQCLTIDVFGALPESGGNTGPAILKYAQDALISVGGACVLARTACACKREIQLGFRTHHSSGSDRHRNIFGHPLKIQGENGYQPPTAHAQTARRSDACPIESTSKNGGYEEFPDTEADIFASAMPSPPEHAQKIGQTTSGNLFVAGYVYRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRR2</accession>
    <name>A0A074ZRR2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166496.1">
        <property type="nucleotide sequence ID" value="XM_009168232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRR2"/>
    <dbReference type="GeneID" id="20317877"/>
    <dbReference type="KEGG" id="ovi:T265_03690"/>
    <dbReference type="CTD" id="20317877"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10814" checksum="B5651370FBEFFE04" modified="2014-10-01" version="1">MCEAPTKLAPYPITSKVTGWLNGSFEALLKVLPEMNPSTSDQVVLRQLYHAEDWSASSPVRRCFSCGQCVKPGYTVMHDCQHNRHIERPPQITSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS38</accession>
    <name>A0A074ZS38_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165986.1">
        <property type="nucleotide sequence ID" value="XM_009167722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS38"/>
    <dbReference type="STRING" id="6198.A0A074ZS38"/>
    <dbReference type="GeneID" id="20317463"/>
    <dbReference type="KEGG" id="ovi:T265_03276"/>
    <dbReference type="CTD" id="20317463"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32180" checksum="130477CEDF4BFFCF" modified="2014-10-01" version="1">MTDQTPSSAVKAKTEAREFLDNLCDKLLTVHVTDGRRFVGQLWCTDSAANLVLGSCVEYPSPSDSFYDDSRRNLMAVIFTYFILKTRTSKNALICCTIIVLGYGYGVNIEGSLGSLSLLGAIFGISSSITCALNSIFTARSLPLVDGSVWRLTFYNNVNAVILFIPYILLVESGNLIGSFWFSPRFWSMMILSGVFGFAIGYVSALQIQVTSPLTHNVCGTAKAAAQTVLAVIIYAEIKTFSWWMSNIVVLLGSAAYTYVRHRELNSNFEANKENHSASSELPYTSPGSKTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSA8</accession>
    <name>A0A074ZSA8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166270.1">
        <property type="nucleotide sequence ID" value="XM_009168006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSA8"/>
    <dbReference type="GeneID" id="20317693"/>
    <dbReference type="KEGG" id="ovi:T265_03506"/>
    <dbReference type="CTD" id="20317693"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12346" checksum="9B49292C76708FA5" modified="2014-10-01" version="1">MQGTAKTDRQRQYLLNFQTDDCGSRTQLLRMPIDDLPHSEAVPSPLDGIGPRGLWTKPQSVKRRFSSDVFIRSKINAVILNVKNQPRGDWSTQFPPGMQTSLENEGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSG5</accession>
    <name>A0A074ZSG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165886.1">
        <property type="nucleotide sequence ID" value="XM_009167622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSG5"/>
    <dbReference type="STRING" id="6198.A0A074ZSG5"/>
    <dbReference type="GeneID" id="20317390"/>
    <dbReference type="KEGG" id="ovi:T265_03203"/>
    <dbReference type="CTD" id="20317390"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45398" checksum="FBD1DFC7E26F3034" modified="2014-10-01" version="1">MARETLNLENKEGFRPDRGCVDYTFTLYQALEQRHMYRRPTILVFLDFRGAFDSVDQSVLLTTLVQQCMPQKFVNIIRSPYSHSSVWDLCFAMVFKVEGDIICVLQIDKALASNNLNTEVSKTVQCSPHYFINYEVEQEWREWTSLSDTTFCRFYQMIQNEGHTLDRSRNTDAADLRMNVNAGSKLSNLIPFAVNSFKRPCCRKVIWKSTAGGVAKTVACAERFKQIVLSSSKQTPDSPPFFNVLKDEPITQLYQLTKISTVKRNCVDRDTMVTYVLEESAIIISLSKDPIPEETFVQLVTSENPSVSSNIPSSLTSFQNPKPLSRRQLVHSKKRKREPTKDPLSKQLDPFRSRPNSALSDKQPVKSIDFPPVMHQSPRLAPALLAVSGAVKKSKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSL0</accession>
    <name>A0A074ZSL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605049">
        <property type="protein sequence ID" value="KER18254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177999.1">
        <property type="nucleotide sequence ID" value="XM_009179735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSL0"/>
    <dbReference type="STRING" id="6198.A0A074ZSL0"/>
    <dbReference type="GeneID" id="20330350"/>
    <dbReference type="KEGG" id="ovi:T265_16185"/>
    <dbReference type="CTD" id="20330350"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="18912" checksum="77F7B9D5A160B0C1" modified="2014-10-01" version="1" fragment="single">MNVGNISKDGTLFLNRLPRGGDYVFRCTVYCTCENEETSSNAQISIYIESELDVGEEDRSEGTARFREPEGEIGVEQSENERELHKISEILSDPAAGLDLLDSKEKQLLKEKLSSLLDRSDGKSPLTPTDEWELRNQLESLVPRGGGQPSDSPGGNRLLRQLLNELTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUB6</accession>
    <name>A0A074ZUB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597921">
        <property type="protein sequence ID" value="KER18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177459.1">
        <property type="nucleotide sequence ID" value="XM_009179195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUB6"/>
    <dbReference type="GeneID" id="20326321"/>
    <dbReference type="KEGG" id="ovi:T265_12153"/>
    <dbReference type="CTD" id="20326321"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15138" checksum="466F3B37A50DFE5C" modified="2014-10-01" version="1">MSDAIKFDACLLSKNIATNIFSSISYNQPADILNKQSENRAGDDYSKADRTDDQTRQAYQEGPLSALPCGQPSPYLSVNKRHQEKLDRTADICCKLTEQSFGNEEDLQQQMKRIHSGGVYMPLGTSRHPVRESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUC3</accession>
    <name>A0A074ZUC3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166778.1">
        <property type="nucleotide sequence ID" value="XM_009168514.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZUC3"/>
    <dbReference type="GeneID" id="20318100"/>
    <dbReference type="KEGG" id="ovi:T265_03913"/>
    <dbReference type="CTD" id="20318100"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="5">
        <location>
            <begin position="146"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1330"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1352" mass="150408" checksum="6B53C468F00AED8C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUD2</accession>
    <name>A0A074ZUD2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165566.1">
        <property type="nucleotide sequence ID" value="XM_009167302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUD2"/>
    <dbReference type="GeneID" id="20317126"/>
    <dbReference type="KEGG" id="ovi:T265_02938"/>
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    <dbReference type="OrthoDB" id="6142323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32781" checksum="F2FA3CC4FCADBFC3" modified="2014-10-01" version="1">MSREDASPLHLPTPFSCAQLSIPLDQHVTRGSNPAFSVNRIQHTTTNNPHKKSGGGPTYSLLVLSVLVRSRCGFAHGLTPTTTAIWVGFSNRAFGSGPQSSYLYLGVLTAYQPTTVCFLESWRQIPPGRHHNSTRRIIRRQVKLSVRADREAWWTRKVEEMEDAKNAGNVRKLFQLIRSTGPRKPLVSETIRDQNGSLICSKAELGNLKEEDKGHQMKIGYVADEPMEERAMQLTRLSLRFLSASCVPKQGSSIHKLQQISLAQEYRADLTRKLVAAAKAIPATSDCDDARRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUU3</accession>
    <name>A0A074ZUU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165084.1">
        <property type="nucleotide sequence ID" value="XM_009166820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUU3"/>
    <dbReference type="GeneID" id="20327196"/>
    <dbReference type="KEGG" id="ovi:T265_13028"/>
    <dbReference type="CTD" id="20327196"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17747" checksum="CBD656BCE79BAC34" modified="2014-10-01" version="1" fragment="single">MQGPTIFTAYNVVRLLGNILVLLLVCFGGALAGTSTYVLVLYENIAEVFGRYVFYGCLYAVLACGIFAIVLGLFAFYDFTQENRFTTILTVVSSICLFTIVLILGIILFSYPRTMQDRVLQAMTSTLPEYGQTNQMTKAWDMMQSFLRCCAIYNLGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV86</accession>
    <name>A0A074ZV86_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165177.1">
        <property type="nucleotide sequence ID" value="XM_009166913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV86"/>
    <dbReference type="STRING" id="6198.A0A074ZV86"/>
    <dbReference type="GeneID" id="20316803"/>
    <dbReference type="KEGG" id="ovi:T265_02615"/>
    <dbReference type="CTD" id="20316803"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF699">
        <property type="entry name" value="INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="236" mass="25916" checksum="5D39D64AECCA22B6" modified="2014-10-01" version="1">MYIANLGDSKVVLGRMVRDLHPVSSDNGDSNKSEESPSGSYSLSAVCLTRDHNPMDYEERQRIQASGASVQNGRVNNILEVSRSFGDYQFKKQGVTCIPDVKKCQLTPNDRFLLIACDGLWKSFPPDEAVALTNRLLLKEFEALSSNGSQSDLSSNPPTCGLTQRHLESVCSHLVNEAVLRMSGDNVTCILLVFPDAFKSPNSISPASQVVKDPLLVKMNSEDTSSEPPPKQSRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVG9</accession>
    <name>A0A074ZVG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166387.1">
        <property type="nucleotide sequence ID" value="XM_009168123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVG9"/>
    <dbReference type="GeneID" id="20327449"/>
    <dbReference type="KEGG" id="ovi:T265_13282"/>
    <dbReference type="CTD" id="20327449"/>
    <dbReference type="OrthoDB" id="6272845at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="33952" checksum="0F034B9EC18283FA" modified="2014-10-01" version="1" fragment="single">LRILLKTVLDPVQIKDAERIGALFSLVHSALCTQKRMKISRMKTTEYNNMQQMRLYVQVEGDAIMSRDGDICQEAIDLTATMAERGHQVNVVYQTVLNYDHRKVVKFLVYHVSIIPTLEIAFPEKWKVGLQGVIDSLGLANSHVTNFQVPLFHDQITTEERVKGVAEPKMQNSFFSRFTDNIHVEIMLKHLLPALVLGEFHCFPYTHVYGYNDGLFSRVKAFVPKTSIQTPRSSEYSDLALVELFKSTWSELSFSLYTHKDEPTYGLLILRDENLAEPNALFITGNNVRYDVTFVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVI4</accession>
    <name>A0A074ZVI4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165156.1">
        <property type="nucleotide sequence ID" value="XM_009166892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVI4"/>
    <dbReference type="STRING" id="6198.A0A074ZVI4"/>
    <dbReference type="GeneID" id="20327216"/>
    <dbReference type="KEGG" id="ovi:T265_13048"/>
    <dbReference type="CTD" id="20327216"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="182" mass="20448" checksum="666DD88C9B2B07FF" modified="2014-10-01" version="1" fragment="single">MQVYFTLVKKLNKYTWSIQKYRMNESPGVGTTFANACDEAQMVNICCLCGKTFTSPSLLHKHFELMHEGTEIDSEQYDLSGLTGESTSSNGGADGFRVLNCAFCNKVFTKNCNLSAHIKTVHKGVKPFECVLCYKGFTRNSDLHKHIDAVHKGLKPFGCKLCRKTFSQKSSLRRHIEAIHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVP7</accession>
    <name>A0A074ZVP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168800.1">
        <property type="nucleotide sequence ID" value="XM_009170536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVP7"/>
    <dbReference type="GeneID" id="20327955"/>
    <dbReference type="KEGG" id="ovi:T265_13788"/>
    <dbReference type="CTD" id="20327955"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15900" checksum="28506B0C855D4A8D" modified="2014-10-01" version="1" fragment="single">MSVVQTRPLHLELSRPGLNNLVLSQPSCLRHSVVFRHRNAVTAERFISNEAKGPTILNLVCYLDYLNSEIHQSRIRRKLFFRFYALLLRSEHSSDSSIRDPKSAAFERAEEPAGADVCLPGVFAVSTPKPVRPSSTALGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVP8</accession>
    <name>A0A074ZVP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165078.1">
        <property type="nucleotide sequence ID" value="XM_009166814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVP8"/>
    <dbReference type="GeneID" id="20327190"/>
    <dbReference type="KEGG" id="ovi:T265_13022"/>
    <dbReference type="CTD" id="20327190"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="226"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="334"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="552"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
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            <begin position="414"/>
            <end position="436"/>
        </location>
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            <end position="881"/>
        </location>
    </feature>
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            <position position="1"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="941" mass="102925" checksum="C6E5CBBE0F25B0F6" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVY3</accession>
    <name>A0A074ZVY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF5745 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="545730at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CEP95"/>
    </dbReference>
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        <property type="entry name" value="CENTROSOMAL PROTEIN OF 95 KDA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="381"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31266.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="57741" checksum="855D789A278C6A70" modified="2014-10-01" version="1" fragment="single">SSPACVLTEHLDKISEVTQVPICHIRASDLLDSDLTAWGNLLEILEFLVNFVRTNESHESLEQSLSSYESTQSLCSPVKHSALEDVRDRVNNLLTELDSKKFPVTSREKAEGQARGDHFSEYSSSDIVDRNLGCAPKTQHNASRLLYLREKLRGCLQDKEFAHLPIDRLRSDPRATSFKHTNGNSCSRTSTSVCGSECGNSGGLVKPRARPLTWYTHDRRTQRPKTPEMETVLTNLLDEPGDLLDKLLAAFPTLDLDGHDTRVLRRKAAQLLGACSAVSSRPTSLPGISPSNRHKLTWVEERNRRRLAQLLRHSMRMSRFRDQKTADEEDRRLRAQLQERRRQLIRIRSYYQQYVSDFRAKKMAKVFEEEKVFRNFFQGLLAQERENLMDIQKLEREERNKCRILKEEQMANLEYTRRARMAFIKERLEQEEAQRTNSQRQQRLELIKQRRELRHTLETNVRELQRIMLENNDSVYFREKDASRMLQHRNEFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX79</accession>
    <name>A0A074ZX79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX79"/>
    <dbReference type="GeneID" id="20325693"/>
    <dbReference type="KEGG" id="ovi:T265_11525"/>
    <dbReference type="CTD" id="20325693"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8387" checksum="0B1B205F72F5ED8E" modified="2014-10-01" version="1">MTAIRLNFIDKQSEVVYKLRTHELTEEVTLLVPSACITEVDDADGAECYFPPSVHPSTSEFTKLSGTKIAVSRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXS0</accession>
    <name>A0A074ZXS0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165511.1">
        <property type="nucleotide sequence ID" value="XM_009167247.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZXS0"/>
    <dbReference type="GeneID" id="20317082"/>
    <dbReference type="KEGG" id="ovi:T265_02894"/>
    <dbReference type="CTD" id="20317082"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="696"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1388" mass="150202" checksum="A83EA844CB390747" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY26</accession>
    <name>A0A074ZY26_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_01578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163901.1">
        <property type="nucleotide sequence ID" value="XM_009165637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY26"/>
    <dbReference type="GeneID" id="20315766"/>
    <dbReference type="KEGG" id="ovi:T265_01578"/>
    <dbReference type="CTD" id="20315766"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="33"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="380" mass="44003" checksum="0531697F1776A6AB" modified="2014-10-01" version="1">MGCLESEYRREEIMVYQFRGYVTPVLVLLGIVGNVLVLATFIVLQNKQKSRFNVHIMWIATFETLDLIFDALLDDFLGRGIHWISDCVIHIKLDTLSSWSCKLMSYSTLLTSFSSNTLLVLFTFDRFLTTYNPIRFRGDFFVGRLSYFLSVVIICLCVLLSPQLVHADVVTDGKTLDQSCMYPNPLHWGVQFILWLMNCGAYIIPTCLIIILNALIIGKFKSNQRNRHRMGVTVNQTQNELPRIVGHLILTSVFLLLTLPLVIVIILRQRADRGNYVTKYPVFEKQLKDLSKLFSSFESINRASLFPICLMFLPNFQQRADRGNYVTKYPVFEKQLKDLSKLFSSFESINRASLFPICLMFLPNFQQVWTRLLYHPRDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYN0</accession>
    <name>A0A074ZYN0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED6</name>
        <name evidence="7" type="ORF">T265_04746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167823.1">
        <property type="nucleotide sequence ID" value="XM_009169559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYN0"/>
    <dbReference type="STRING" id="6198.A0A074ZYN0"/>
    <dbReference type="GeneID" id="20318928"/>
    <dbReference type="KEGG" id="ovi:T265_04746"/>
    <dbReference type="CTD" id="20318928"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="30812" checksum="61BE04DB0D90046E" modified="2014-10-01" version="1">MTSEEENLYGISWSNPAWSHLLCAANVLDYFCDLSNPFYDRQCNNEVIRMQRLSAEQLLCMTGVEFYLHHAQEPILFIIRKQQRLTSTQVTPLAYYYIINGTVLQAPDLTTLLSSRLLTTVNSLNKALQTLAPCARYHPSDGSYSWDDPNTLLGLTNVDTEGVVSPVKSGQSSKSEQPPANLFQVQRADFLLAEWANRFPLPSPAFANAVSGASFPSSTVALPMTTSHSISLPGTIKEEPTTGEPVQMVRPSVKPTVLPPNVPAPGSFPSSPQMDKKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZA7</accession>
    <name>A0A074ZZA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163506.1">
        <property type="nucleotide sequence ID" value="XM_009165242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZA7"/>
    <dbReference type="GeneID" id="20315445"/>
    <dbReference type="KEGG" id="ovi:T265_01257"/>
    <dbReference type="CTD" id="20315445"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12840" checksum="86C037761CC882CE" modified="2014-10-01" version="1">MDSEYIRHIRMSTGHAAHLRARWRSLGYSVLKNSNPPSPAHRFLYGNEEKNRLMKHTTRPKVTASQQYRGMEPRRRSNASFEANALDMSGARPALATSTAGKLLACATPALMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZJ2</accession>
    <name>A0A074ZZJ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167578.1">
        <property type="nucleotide sequence ID" value="XM_009169314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZJ2"/>
    <dbReference type="STRING" id="6198.A0A074ZZJ2"/>
    <dbReference type="GeneID" id="20318732"/>
    <dbReference type="KEGG" id="ovi:T265_04550"/>
    <dbReference type="CTD" id="20318732"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13290">
        <property type="entry name" value="PH_ORP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000089">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000014">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF200">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="868" mass="96849" checksum="CDC63CE3C31DF525" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZJ3</accession>
    <name>A0A074ZZJ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597040">
        <property type="protein sequence ID" value="KER20589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175660.1">
        <property type="nucleotide sequence ID" value="XM_009177396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZJ3"/>
    <dbReference type="GeneID" id="20329450"/>
    <dbReference type="KEGG" id="ovi:T265_15285"/>
    <dbReference type="CTD" id="20329450"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="34282" checksum="085C44F2AB8B93C2" modified="2014-10-01" version="1" fragment="single">AYSPGSRQPYVLLEPELDCFREIHSFANQFGPDCAYLCEIFEKYTHLQIDLIFTRDSTETLVYNNLQPKVLHTGRLMFHLARYSRYRSIFSQRNLLIRLLKTLRQPTPSWSSSGRRSPRVSVMFYLTFYFLRAMVRPDWRVSRSSQPGQLLGRRSMCRAHQSHRSSVNAFACSEVTFQMRPTCVSGVVVTRSHRMSDVRGSNPGTGIGYALLRNLSQVLPLGVDGLTGIITPEHEHGRSRESGVTMNRKTTLQVRWARSSSFRQPYVLLEPKLSKYTHLQINLVLTGEFFLFMMFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZP5</accession>
    <name>A0A074ZZP5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167460.1">
        <property type="nucleotide sequence ID" value="XM_009169196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZP5"/>
    <dbReference type="STRING" id="6198.A0A074ZZP5"/>
    <dbReference type="GeneID" id="20318629"/>
    <dbReference type="KEGG" id="ovi:T265_04447"/>
    <dbReference type="CTD" id="20318629"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="825" mass="90919" checksum="B0FB1655F3955E21" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZX4</accession>
    <name>A0A074ZZX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167404.1">
        <property type="nucleotide sequence ID" value="XM_009169140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZX4"/>
    <dbReference type="GeneID" id="20318583"/>
    <dbReference type="KEGG" id="ovi:T265_04401"/>
    <dbReference type="CTD" id="20318583"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7439" checksum="70594DD91DC17BA9" modified="2014-10-01" version="1">MWVSNKPDLEMGMFDIPSGLRRLNRSTKVTADQEEARGFRGKPTSREDIRSGANNPALFVVMTDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A014</accession>
    <name>A0A075A014_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163603.1">
        <property type="nucleotide sequence ID" value="XM_009165339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A014"/>
    <dbReference type="GeneID" id="20315521"/>
    <dbReference type="KEGG" id="ovi:T265_01333"/>
    <dbReference type="CTD" id="20315521"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10929" checksum="A3CD575D7D7B5C1A" modified="2014-10-01" version="1">MNAQVWMTKSGRSTLPLAMRSYLPLPQTIGERNCGSYNHSTKSTRLLQLTMMMMMISGQCELPTQTLTLSYLETTYHKTVVDSVGPYGYQLPMESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A035</accession>
    <name>A0A075A035_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163620.1">
        <property type="nucleotide sequence ID" value="XM_009165356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A035"/>
    <dbReference type="GeneID" id="20315538"/>
    <dbReference type="KEGG" id="ovi:T265_01350"/>
    <dbReference type="CTD" id="20315538"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12062" checksum="CE5D77B2E0F7F337" modified="2014-10-01" version="1">MLLIQHEFISPLALQKHNVAIHVRTWQTIEFCMSTEIRTLSKHKSDFGIRFSSPDETDLWEGPVKQVTEVVWDENIASSQKPFFKIPKFVSAEIEEGILHKPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A122</accession>
    <name>A0A075A122_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162848.1">
        <property type="nucleotide sequence ID" value="XM_009164584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A122"/>
    <dbReference type="GeneID" id="20314923"/>
    <dbReference type="KEGG" id="ovi:T265_00735"/>
    <dbReference type="CTD" id="20314923"/>
    <dbReference type="OrthoDB" id="6256068at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="525" mass="57336" checksum="DCB16C5D4B78177B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A186</accession>
    <name>A0A075A186_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_00610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:34936"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Gly) + glycine + ATP = glycyl-tRNA(Gly) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16014"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162702.1">
        <property type="nucleotide sequence ID" value="XM_009164438.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A186"/>
    <dbReference type="GeneID" id="20314798"/>
    <dbReference type="KEGG" id="ovi:T265_00610"/>
    <dbReference type="CTD" id="20314798"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
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        <property type="entry name" value="aa-tRNA-synt_IIb"/>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="Anticodon-bd"/>
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        <property type="entry name" value="Anticodon-bd_dom_sf"/>
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        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
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        <property type="entry name" value="GlyRS-like_core"/>
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        <property type="entry name" value="tRNA-synt_gly"/>
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        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
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        <property type="entry name" value="WHEP-TRS_dom"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA-synt_2b"/>
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        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRNASYNTHGLY"/>
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    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="18">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="209"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="564"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="743"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="835"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="930"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="985"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1169"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1219"/>
            <end position="1292"/>
        </location>
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        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
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        <location>
            <begin position="634"/>
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        </location>
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        <location>
            <begin position="672"/>
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        <location>
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        </location>
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        <location>
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        <location>
            <begin position="937"/>
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        <location>
            <begin position="1019"/>
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        <location>
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        <location>
            <begin position="1230"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019404"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048436"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049523"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142738" checksum="471753DF83A3897D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2K8</accession>
    <name>A0A075A2K8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="342" mass="39056" checksum="47858C62AABCBACF" modified="2014-10-01" version="1" fragment="single">EDTVLISRSKKIWCQPSRRRGSDRQIINEYKLNPGMAIGYALLMSINKSETRVQCFLWCGPTGIIAPEQEDGRSNESGVTTNKIHIPRKPQNCNYRFIGRVPLSNKLQPPRSSALFVHKYEPVTKSGNKHNALVCQEIIVYVHRTQRVCKAWLTCFLGYFFPETKVPLEALSVLVLVRRSFVIATVVNQRVLQFRWITHDTGCVRTNQVAWELANSYQFSGMHIFEELRAPTSASFIKPHLCAFQGPLAAVTNFSLNAFAFFGIKEAEKRYLLFFPLITSALHIILREADFLVHQKMIIFIEAAALLSLSRLLLKCVFQRSRAVCELAVFALYDSFICSRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A474</accession>
    <name>A0A075A474_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">T265_14930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175826.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20329096"/>
    <dbReference type="KEGG" id="ovi:T265_14930"/>
    <dbReference type="CTD" id="20329096"/>
    <dbReference type="OrthoDB" id="6260475at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705616" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="248" mass="28181" checksum="5A813EA1F18E8FF5" modified="2014-10-01" version="1" fragment="single">MVGKLLCVFVSLLHVCYGIERSRGALGPRVFTFVHGDDSARLDFMTADSYCRTRVGTEQPPSKPVGIIEHEDGVFAKQRHRSFSNETNSDDLMLETRLASLHSYPETLALVKWISKQEKHSFWIGGTVTKTLNEYLRPIYVLQWTDGSRGDFSFLKLPSEELSEIRVGEQRCISVDYLSGQWGLHPCEEKRYFVCLTVPVLRNKVRHTLPTTIPSPAKQPSWVAPPPVLRSPSPRNQLTAEELRRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A651</accession>
    <name>A0A075A651_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162541.1">
        <property type="nucleotide sequence ID" value="XM_009164277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A651"/>
    <dbReference type="STRING" id="6198.A0A075A651"/>
    <dbReference type="GeneID" id="20326721"/>
    <dbReference type="KEGG" id="ovi:T265_12553"/>
    <dbReference type="CTD" id="20326721"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8230" checksum="B5FEB1249E74048C" modified="2014-10-01" version="1" fragment="single">MVNELSHSIESVKLEMEYVALRTNIHWNINQNTNFRVVLWAAFEAVLIITMSIGQVFYLKRFFEVRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7U0</accession>
    <name>A0A075A7U0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164519.1">
        <property type="nucleotide sequence ID" value="XM_009166255.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20316284"/>
    <dbReference type="KEGG" id="ovi:T265_02096"/>
    <dbReference type="CTD" id="20316284"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1479" mass="163468" checksum="4CDD252AF1F08BE5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8S0</accession>
    <name>A0A075A8S0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164091.1">
        <property type="nucleotide sequence ID" value="XM_009165827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8S0"/>
    <dbReference type="GeneID" id="20315925"/>
    <dbReference type="KEGG" id="ovi:T265_01737"/>
    <dbReference type="CTD" id="20315925"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13876" checksum="8E88F81223AA7584" modified="2014-10-01" version="1">MFKIMTRKSFKEPHQTEFAKTFPTTLILKVFDLTQCEFIECKMCPVIYGDRLESLPQSTAKVSGKLQQQRPKFFEPISSATANLNPVHCQFYATPKNDKRLGRRNLSMRYSCPSKRHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB10</accession>
    <name>A0A075AB10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl-hydrolase family 116 catalytic region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171497.1">
        <property type="nucleotide sequence ID" value="XM_009173233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB10"/>
    <dbReference type="STRING" id="6198.A0A075AB10"/>
    <dbReference type="GeneID" id="20321839"/>
    <dbReference type="KEGG" id="ovi:T265_07660"/>
    <dbReference type="CTD" id="20321839"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 N-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="3">
        <location>
            <begin position="601"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1200" mass="135830" checksum="B4CC8FB6CA42D257" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD01</accession>
    <name>A0A075AD01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170497.1">
        <property type="nucleotide sequence ID" value="XM_009172233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD01"/>
    <dbReference type="GeneID" id="20321030"/>
    <dbReference type="KEGG" id="ovi:T265_06851"/>
    <dbReference type="CTD" id="20321030"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704575" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13020" checksum="58B03C369C38A62D" modified="2014-10-01" version="1">MLPLKLKAILFVTAISTSFQFGFHTGVINAPYQVVDFVSLPSVQLISDFIGNVTADRHGSADEAYEKGDSSPISPLCPRLYFHHGLPSSQILRNHHCWQTSCGCCLWYVLHCQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADF8</accession>
    <name>A0A075ADF8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161956.1">
        <property type="nucleotide sequence ID" value="XM_009163692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADF8"/>
    <dbReference type="STRING" id="6198.A0A075ADF8"/>
    <dbReference type="GeneID" id="20314223"/>
    <dbReference type="KEGG" id="ovi:T265_00035"/>
    <dbReference type="CTD" id="20314223"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="391" mass="43875" checksum="3463B40B44B7D00A" modified="2014-10-01" version="1">MSDHESEELDVLDDVVVTKYKMAAEVTNSTCEFQLMLLLSEGVLSELIKLSLPGAKIVELCKLGDQRIQDESAKLFKREKTMKKGISYPTSISVNNIICHYSPIDGEENEIVELKDGAHIDGYAAVVGHTFVVGSSSDNKVTGRKADVIIAANTAAEVAVRLLRSNYEVFSLHNPTVCAGMQSHQMRRMVYDAEKSIVLNPSEEHKKSIEKTNFELNEVWNIDILLSTGSGKPRDHKARTTIYKKNETLYQLKMKSSRQLHSEIASKFLAYPFNIRALEDLKKARLGITECAKHDVVQALPVYCEKDDEFVAQFRFTVLLMPNGPMRITGFPFDASLYKSEFKPRDAEVKVCLLMSSYFAKDILLQPIKTQNKKKKGAKPSSQSTGETDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADQ7</accession>
    <name>A0A075ADQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170016.1">
        <property type="nucleotide sequence ID" value="XM_009171752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADQ7"/>
    <dbReference type="GeneID" id="20320657"/>
    <dbReference type="KEGG" id="ovi:T265_06478"/>
    <dbReference type="CTD" id="20320657"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17645" checksum="FD010EB19C1970EE" modified="2014-10-01" version="1">MLRPLGLYREMMGEIRLLSTFQTDKLAANMQPVSVVFAHEVILRYSPIQRARIYQWNICIFVTETLGEQVAHSPPQGLHAQRCTAKHLLNDTTTYKLNDHVPSSNIINPINMTLKKLRATQGITRQGRWKMKADDTNVAQFYGLKRCTKKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADW4</accession>
    <name>A0A075ADW4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169894.1">
        <property type="nucleotide sequence ID" value="XM_009171630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADW4"/>
    <dbReference type="STRING" id="6198.A0A075ADW4"/>
    <dbReference type="GeneID" id="20320561"/>
    <dbReference type="KEGG" id="ovi:T265_06382"/>
    <dbReference type="CTD" id="20320561"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34869" checksum="0AEFFC1132EAC1C4" modified="2014-10-01" version="1">MKEITKRLGAVGATRLPGWGQRDPHCAWLKTLQYMGANRCQCSSCCQLLSRSPALSNKSWLYGSEASVLNTDVMLSIMMMSHGSHILSVWLTSGAKKMLSSRLSSLVTRPPRIFQRAPPLVTINRLTSQTLAYPSVPTLVMFTKPDCSLCRAAIEQLRPYANKYHAPELQVLRWKRNMMFVGAWWKSDWGADLLTGRSVVRTRPLPLDLPCLCLGDLAVFQPSCFIRAAWQLGTEKFRLQLVDITEAKNSVWRKYQYDIPVFHILSVGTQLTHENKGTYLMKHHVDWNRLKNSIPELDQCPELDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGX4</accession>
    <name>A0A075AGX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167092.1">
        <property type="nucleotide sequence ID" value="XM_009168828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGX4"/>
    <dbReference type="GeneID" id="20318344"/>
    <dbReference type="KEGG" id="ovi:T265_04158"/>
    <dbReference type="CTD" id="20318344"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10879" checksum="2B34555690FD379E" modified="2014-10-01" version="1">MKSSATPFFHLCLSATDRQEQNLETWAKASILCMNLTAFVHKPPFERVGFWGFARNSMWFNRLLESTHSTQIRKSNLKYPVDLRRSAELKSGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGY6</accession>
    <name>A0A075AGY6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167049.1">
        <property type="nucleotide sequence ID" value="XM_009168785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGY6"/>
    <dbReference type="STRING" id="6198.A0A075AGY6"/>
    <dbReference type="GeneID" id="20318313"/>
    <dbReference type="KEGG" id="ovi:T265_04127"/>
    <dbReference type="CTD" id="20318313"/>
    <dbReference type="OrthoDB" id="6152726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="19658" checksum="4D760EA59EA35634" modified="2014-10-01" version="1">MEYAIQAWSPWLQKDIILLQRIYHRATKLVIGLQNKPYEDRIASLNLFDFYYRRIRGDLILTYNILKTPNHPLEDLFVRRRTRTGRRHNFSLAVPHSRVNCRRNFFAVRVCFIWNSLPPNVVHSPKCPLVAALNAQMTQRSLTEALSRPDGTRNLKKPNESEFITNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH37</accession>
    <name>A0A075AH37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166879.1">
        <property type="nucleotide sequence ID" value="XM_009168615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH37"/>
    <dbReference type="GeneID" id="20318183"/>
    <dbReference type="KEGG" id="ovi:T265_03997"/>
    <dbReference type="CTD" id="20318183"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="20019" checksum="F487AD125750A15B" modified="2014-10-01" version="1">MKLAKYTHSHSHSIQLLEKCALTVHNLNINVSERLCSRRVSWSSSWHTISVDIVKVSGDIEQDGQWLERELTDRKVRGSNLTSASRIPLSTLGKGETRMWKGHKHYNHSEMPKPPETHSGNLDICHSGESTPKGEKHWTRVSRLLKPTSSAYPTAVPGSGLRTSVVRGERLTTNPQAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHB9</accession>
    <name>A0A075AHB9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166676.1">
        <property type="nucleotide sequence ID" value="XM_009168412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHB9"/>
    <dbReference type="GeneID" id="20327505"/>
    <dbReference type="KEGG" id="ovi:T265_13338"/>
    <dbReference type="CTD" id="20327505"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8849" checksum="1192580518E61222" modified="2014-10-01" version="1">MQQDVENALLRRADLLSDGCLQRNMQKVPTSWRILPEFIRVLQPKMHLEMQVEELQYTACKKLPLNQQSCTQNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHH0</accession>
    <name>A0A075AHH0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED8</name>
        <name evidence="9" type="ORF">T265_03567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166350.1">
        <property type="nucleotide sequence ID" value="XM_009168086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHH0"/>
    <dbReference type="STRING" id="6198.A0A075AHH0"/>
    <dbReference type="GeneID" id="20317754"/>
    <dbReference type="KEGG" id="ovi:T265_03567"/>
    <dbReference type="CTD" id="20317754"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="476" mass="53867" checksum="B992E3071AE6B228" modified="2014-10-01" version="1">MEARASGTTEDAGGFRKPRGWITLSLQAETAPCFNWFDKRVKRRRVSVRQCARKTKWQFTPSIVILSGGLSTSKNVSSGLLQRNRWKNQVGPNGTLTPTHHKQPESTRQGTWPGWCTPRTLQRRWRGPDEQSDKHCRRFGTKTIPAEWSASTVIPVFKKGARPSCKNHRGINLVSVVSKVLSGIILRRFLDYRERHIRENQAGFRRGRGCIDHIFTLRQTLEQRRPSDIPRSCDKADGSITDEVNARIVKALSTSFRVRHPWRSSNIRLPVKDGIYSVPICPATERRQMESVKTLYNALYKLKQKVQDLVIKLETQGESCDWPRYLSTLALCASELSEIRKVLESDRFSSEHTLALTPMLLNPEPDPTLAKATEDRLALFNHDTVPQYLRTKLDPKLESQCLAQSSRASAVPSDQLTKLINQTNRAVDASLKEVSLLKQELEADFSDRQSKTTGSVEDFNALLSLVISGKGLNTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHW2</accession>
    <name>A0A075AHW2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165706.1">
        <property type="nucleotide sequence ID" value="XM_009167442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHW2"/>
    <dbReference type="GeneID" id="20317240"/>
    <dbReference type="KEGG" id="ovi:T265_03053"/>
    <dbReference type="CTD" id="20317240"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704650" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8384" checksum="4B6364792C37F5AA" modified="2014-10-01" version="1">MLLILWGLLMNNPGERLSTCNYPVVEQDQSGAVSDRFQEDERTALQALRTMVVLVKMQIHLVNAALGCQMATGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI62</accession>
    <name>A0A075AI62_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165202.1">
        <property type="nucleotide sequence ID" value="XM_009166938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI62"/>
    <dbReference type="GeneID" id="20316828"/>
    <dbReference type="KEGG" id="ovi:T265_02640"/>
    <dbReference type="CTD" id="20316828"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14372" checksum="099BDE14F81D2F7C" modified="2014-10-01" version="1">MTSFSPSIKREGPDDPRAEKGKVVMRRYFVSTQKTGHPHAKKPVSDICFVFTNKKISFRLSSKFTEDKKLPRVLYPFSYVLLTIGFRRLIQRRRILVSVRGKPIVVQTVNIAVYSDEDPSAPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIU5</accession>
    <name>A0A075AIU5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164006.1">
        <property type="nucleotide sequence ID" value="XM_009165742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIU5"/>
    <dbReference type="GeneID" id="20315864"/>
    <dbReference type="KEGG" id="ovi:T265_01676"/>
    <dbReference type="CTD" id="20315864"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15319" checksum="17C889301D118598" modified="2014-10-01" version="1">MLKTNSDISEIKKPDEDEVVSLTGANLDSRVHLAAACNSCRFWMPSNTGSSYLVVDRVVIEEAGCLRTDTSSGPQKIEDDNSGVSREEMRWRLMQQIGRYSAALINTALGGVTQNPRTAAPGDGKTVCASSLLELTTGNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ37</accession>
    <name>A0A075AJ37_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_12742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163529.1">
        <property type="nucleotide sequence ID" value="XM_009165265.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJ37"/>
    <dbReference type="GeneID" id="20326910"/>
    <dbReference type="KEGG" id="ovi:T265_12742"/>
    <dbReference type="CTD" id="20326910"/>
    <dbReference type="OrthoDB" id="2156623at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="810"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1094"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1784"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1950"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1500"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1574"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1784"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1950"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1984" mass="222738" checksum="2CF64974186B6D18" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ56</accession>
    <name>A0A075AJ56_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">[Acyl-carrier-protein] malonyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_12760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II malonyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163547.1">
        <property type="nucleotide sequence ID" value="XM_009165283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ56"/>
    <dbReference type="STRING" id="6198.A0A075AJ56"/>
    <dbReference type="GeneID" id="20326928"/>
    <dbReference type="KEGG" id="ovi:T265_12760"/>
    <dbReference type="CTD" id="20326928"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000005">
        <property type="entry name" value="Malonyl-CoA-acyl carrier protein transacylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="367" mass="41316" checksum="B4352FB5ED2DC351" modified="2014-10-01" version="1">MYLRLVAHISKIRTVCTHYLSRKLCQTDSSVRGSWKGWTQYENRPQHTDIEQTSVFLFPGQGSQFAGMGKNLLRVPKVREMFQCANEMLRTDLLKTCLEGPQSKLDQTVHCQPATYIISLASVAKLQEDEDEVVRNCVATAGFSVGEVTALVFAGSMTFEQGLHVIRVRAEAMQKACDRIKGAMTSVFLSHDSQLKLAISAALEHCKTHYKLENPECRIANYLYSDCKVVAGHLQAIEFIEQHAPQFRIRRVKRLPVNGAFHTSLMRSAVEPVSRAVSRIDQLKSPSIPVVSALDILPYTTVESVRRKLSLQLVRPVKWEQTLHALYIRPPDTPFPVTVEPGPGKQLGAMLRMTNRKAFAHYRALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJD3</accession>
    <name>A0A075AJD3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163041.1">
        <property type="nucleotide sequence ID" value="XM_009164777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJD3"/>
    <dbReference type="GeneID" id="20315070"/>
    <dbReference type="KEGG" id="ovi:T265_00882"/>
    <dbReference type="CTD" id="20315070"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19436" checksum="88E81F669D376A35" modified="2014-10-01" version="1">MAVPGFELRTADMRGERVATIPPAYHSFGAELPCHPKEARELGYCQVAQAQTGKIERQRSGSNHGSSGQKIRALTTLAISLSINSPNTDRTNTRANEIETAQWLTRESNDGKFRSLKPNLNIFTAPVWPDSTSAVLPPSGDTTSKHRKDITPNMNQYEFSKDRETEFPHQTSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG7</accession>
    <name>A0A075AJG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162793.1">
        <property type="nucleotide sequence ID" value="XM_009164529.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJG7"/>
    <dbReference type="GeneID" id="20314868"/>
    <dbReference type="KEGG" id="ovi:T265_00680"/>
    <dbReference type="CTD" id="20314868"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="644"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="963"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="893"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1410"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="157176" checksum="C169DC648BD497C4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJM2</accession>
    <name>A0A075AJM2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162588.1">
        <property type="nucleotide sequence ID" value="XM_009164324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJM2"/>
    <dbReference type="GeneID" id="20314708"/>
    <dbReference type="KEGG" id="ovi:T265_00520"/>
    <dbReference type="CTD" id="20314708"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9866" checksum="BE7C6DA3AFF89C3F" modified="2014-10-01" version="1">MAPSDRLSPEQSLLIHVVIAGTTLIVRCVWRTSPSGMFATPLITGRIEFIMHWQLGNDIPLSLCQPSAPESGHEGLDSPELYDHSDRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJM4</accession>
    <name>A0A075AJM4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U transporter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_00530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162598.1">
        <property type="nucleotide sequence ID" value="XM_009164334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJM4"/>
    <dbReference type="STRING" id="6198.A0A075AJM4"/>
    <dbReference type="GeneID" id="20314718"/>
    <dbReference type="KEGG" id="ovi:T265_00530"/>
    <dbReference type="CTD" id="20314718"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024721">
        <property type="entry name" value="Snurportin-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11538">
        <property type="entry name" value="Snurportin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="13">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="406" mass="46479" checksum="F83061E45B61358B" modified="2014-10-01" version="1">MSMKSLVNESVAETALLLWTKLKELTGKSMEDACMESILSQLDSGLAVDFNHSSTVVEDRQKHPRITLYKNSGRIADQQRRWREELAAVNRKKQRDGKFDTNRGLRSLEDATQENTEDDSALLCNPWAQKPKKYHGKSWRSYSAHLMLAEWLLFLPPTFHENYMMKLCPKGRHVFVWAAQGSTRIISRTGWVLKKTVSRLPGGGLGQSEHQNATYCTMLDCILLNLTAPSGDNSMQICDGDNASTDLPLEFKVLDLIRYRGTCYASLPFRERCCWMEQYLHSQIEESQEDDPVRFEVIPAYSCDLESMNAVLSVKPKYEVDGILFYHEVVTYEPGATPLVGWLKPYMLSEWFPEVTLHPDHMADIPADYTDYRNEVRAQEERARCKLKSPNKQVNCDSVGEHSIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJV5</accession>
    <name>A0A075AJV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162199.1">
        <property type="nucleotide sequence ID" value="XM_009163935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJV5"/>
    <dbReference type="STRING" id="6198.A0A075AJV5"/>
    <dbReference type="GeneID" id="20314415"/>
    <dbReference type="KEGG" id="ovi:T265_00227"/>
    <dbReference type="CTD" id="20314415"/>
    <dbReference type="OrthoDB" id="6286681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="22636" checksum="50E73D975B369E97" modified="2014-10-01" version="1">MDGGVATFTGMEMLIAWRKHYCSQSPVAAINMGKPKRPLGCPQRPRHARVSVDNAMKYQVIDTALQFPKSPERRLVIIMGCLPHLFRARVTPFPKVPHLTSPDQLRPISVSSILVRCFHKVLADRSSRRLQLFSLQFAFMHRDGCLEATSLLHALLRHSSATASNLSLAFVDKSKVFDSVSHDTIVRSAEAFGALSPLVRYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTI5</accession>
    <name>A0A074YTI5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL611028">
        <property type="protein sequence ID" value="KER18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178147.1">
        <property type="nucleotide sequence ID" value="XM_009179883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTI5"/>
    <dbReference type="GeneID" id="20326543"/>
    <dbReference type="KEGG" id="ovi:T265_12375"/>
    <dbReference type="CTD" id="20326543"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8303" checksum="D31DEB18221BC875" modified="2014-10-01" version="1">MNSNHVYQIEWNVTSDYRPKLHISHPTGPEAPESMHRILNDEVCILVRQPPWNLSGFTDNPKDNQHQTLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUR1</accession>
    <name>A0A074YUR1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601251">
        <property type="protein sequence ID" value="KER18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177810.1">
        <property type="nucleotide sequence ID" value="XM_009179546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUR1"/>
    <dbReference type="GeneID" id="20326440"/>
    <dbReference type="KEGG" id="ovi:T265_12272"/>
    <dbReference type="CTD" id="20326440"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8772" checksum="C31F6DEC42C49439" modified="2014-10-01" version="1">MTVFSLGRYIIRTQQHWSRLSGLSRFTHSVAPSPLFPWLPKELEPKFLSYKKHLFAEYEHLTNLIANGAGQQSNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWN8</accession>
    <name>A0A074YWN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597301">
        <property type="protein sequence ID" value="KER19171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177081.1">
        <property type="nucleotide sequence ID" value="XM_009178817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWN8"/>
    <dbReference type="STRING" id="6198.A0A074YWN8"/>
    <dbReference type="GeneID" id="20326133"/>
    <dbReference type="KEGG" id="ovi:T265_11965"/>
    <dbReference type="CTD" id="20326133"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="27564" checksum="D0D386D2D0A2ABAC" modified="2014-10-01" version="1">MQIGEYAIPGFNVQLIENLRLLPNFLRYFSGKLGLAPTSDLLAENFVQALQRLLPNEPVFTFWFRPDEDGVFRSGIFSFGGIHDYRSEGQVIYHPLVSVDSWIIQATKILLGQVVLCEQHCNIQFNTALPYLYGPQEKIEEAQRLLDVETNRMHLGAHVMDCNENYPLLIVHFGGQQLQWRMNDFWEKRMDRRKVTCILGMRASSSGPGWIFGHRVMFRLFTVFDRIGSRIGIAKANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWV0</accession>
    <name>A0A074YWV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597262">
        <property type="protein sequence ID" value="KER19271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176980.1">
        <property type="nucleotide sequence ID" value="XM_009178716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWV0"/>
    <dbReference type="GeneID" id="20329762"/>
    <dbReference type="KEGG" id="ovi:T265_15597"/>
    <dbReference type="CTD" id="20329762"/>
    <dbReference type="OrthoDB" id="6235099at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="400" mass="45199" checksum="6268D2F92AC44379" modified="2014-10-01" version="1" fragment="single">MGNCLQTNDKQRQTKAKQMASVSELGNKNTNIRHRERLRSDIQNPNDPSYPDSSLRIRQDVPQEQAKFIQAHGDKDVAPQQQTSGSIAVRSGGDGIKTVGTDQKTGKADPSWVRYLSQAKARDDMAMDGDVSSAFGENWDPELFDRCGSPMDLSRYPNEEPMVHRNYTDKQSFAQGSKLQKSEWEKWASEESLTVSPKRSRFPIISSSVLGFSPLRPNAEDTMEWFRNGELESPQPNTTNFLIKGKQKQCERDDLNDNPSDPEFVGSESATKEVYGHREGWIRYTMFLHQERADICGFYAKLRNAKHVFLSLEAKTGCELRLSKRLFLHRGKLVRTVVIDGPSRKHILRCHSSLPSILTKLMIQECERPSDSDAKPVVKAHCAESLIDNYPTMFQSTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWY6</accession>
    <name>A0A074YWY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KL597244">
        <property type="protein sequence ID" value="KER19321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176927.1">
        <property type="nucleotide sequence ID" value="XM_009178663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWY6"/>
    <dbReference type="STRING" id="6198.A0A074YWY6"/>
    <dbReference type="GeneID" id="20326032"/>
    <dbReference type="KEGG" id="ovi:T265_11864"/>
    <dbReference type="CTD" id="20326032"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="7">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="8">
        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="381" mass="41600" checksum="DEA2CB5DC21776FC" modified="2014-10-01" version="1">MQRFKRYDIKYLVKNRIPCRKGTVRNKKTSAAPNPSHLGIFWEMYAEDNTPLLNFIIKLIRLAVRLLQSQLFLLLMSGDTGFSVDGSVMEGGGQILRTAVACAAIICRPVHVNNIRAGRPKPGLSNQHLTGIILCAEISGGELSHCRLGSTELQFKPRSVRCGTYEADAKTAGSISLLLQVALPVLAYAGSGSSSILLLKGGTDAQFAPPIDYMSEITLYFLEKMGLDCELEVIRRGFYPQGGGVVKAQVHRLSSPLLPITMLDPGPVDHVSGYAFVAGRVPVKVAHEMERECVRCCSQSFPSCPVKIRVFREDDNHCTGNVSTFLFIVHTKNGSRLAVSGLGNPRGPHHTKLVQDAIARLTTLVHLRACCDDNMQDQVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY55</accession>
    <name>A0A074YY55_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597171">
        <property type="protein sequence ID" value="KER19603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176650.1">
        <property type="nucleotide sequence ID" value="XM_009178386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY55"/>
    <dbReference type="GeneID" id="20325840"/>
    <dbReference type="KEGG" id="ovi:T265_11672"/>
    <dbReference type="CTD" id="20325840"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="17719" checksum="08C0CD1728C91B97" modified="2014-10-01" version="1">MAFFLLSSHKPVQGLPPAADGHLGSGHSEATRTIADLGILNVLSEAQLIDYKRFTILCVCNFLVRNAVGAALSGNVYVVDCGQINQLPTLIYTFQGFELSLLPEQYVQERETRGPTQCFSSIVSDPGIRNEDMVLGMSSMEHFLTMFDQETKSVGFQPRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY69</accession>
    <name>A0A074YY69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL609676">
        <property type="protein sequence ID" value="KER18132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178121.1">
        <property type="nucleotide sequence ID" value="XM_009179857.1"/>
    </dbReference>
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        <source>
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        <source>
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    <sequence length="146" mass="16136" checksum="2E0C1346388EBEA3" modified="2014-10-01" version="1" fragment="single">MAFLKTGQVGFIHCAFDEVLEKAHRPSHHVSYRMNNTESGVLIDLAQPESVSIAIDPANTNFTVRRYKVVGISAKEYTGLLITTCTSVFSNLTAELDIYSPDRSVEINCSRTFTIQEPANGELEIKTIAQNYAHQPVPLGTEFICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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            <taxon>Opisthorchiidae</taxon>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
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        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
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    </dbReference>
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            <end position="395"/>
        </location>
    </feature>
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        <location>
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            <end position="373"/>
        </location>
    </feature>
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            <end position="387"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KER19841.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44919" checksum="A3FD648F9BE01D1A" modified="2014-10-01" version="1">MLVVFLDRKAAFDSVDRQKLRWCLIFKGVPSKFISFMTALYANSRGFVRQGCPLSSFLFNFVIHVLLEISLPDSETSEVEMLSLYYPMDASTETGQPINELSLPLVELFVKAAPSNPSEIAPGLLDHQWLMVLRVLEDKHLIRLRVTPISIKNPPESYIKLNVARCIPIAWIESGLLEGENAAGSVINSSGSLETLMVKVGLSYLDPKLKLDDIKEAESVFEDLYKNLMHYVRNNVSSRLLSSLTKLNQYMASKPGPYLLGPELSYADCQLMPKLQHVRVAGHAYKEFEIPRDLTHLWKYIATMYKCEYFRNSCPSDRDMLMQYAERDPLSKDFHPGLLGPGFSDAIPEDVQFGHQQQQSLQTEHKEYEEHPENTTPQFEAQHSQENGDVEVDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
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    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER20583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="CTD" id="20325072"/>
    <dbReference type="OrthoDB" id="6239425at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="836"/>
        </location>
    </feature>
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            <begin position="1162"/>
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        </location>
    </feature>
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            <begin position="1287"/>
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        </location>
    </feature>
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            <begin position="1373"/>
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    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER20583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1420" mass="154272" checksum="DD834FBDBFBD4E6C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1B3</accession>
    <name>A0A074Z1B3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrator complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1B3"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="139584" checksum="5A130E645AD0B853" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1M3</accession>
    <name>A0A074Z1M3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10655</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
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    </dbReference>
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    </dbReference>
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            <end position="590"/>
        </location>
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    </feature>
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            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="816" mass="90951" checksum="8D4989132F689AEE" modified="2014-10-01" version="1"> </sequence>
</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KER20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7585" checksum="CDA2FA683250AD9F" modified="2014-10-01" version="1">MKIRLRGNTKQGKEFLGVSQSTVDSSNLHIEINSAYALLRAKDHQLSVVTLSQYRLSDRRTKKPDSP</sequence>
</entry>
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        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">T265_15477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <ligand>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="339" mass="39127" checksum="D8FBB590CBB49A73" modified="2014-10-01" version="1">MHPVTYQEPKYWCSVVYYELNNRVGEAFNALQPSIIIDGFTDPSNNADRFCLGLLSNVNRNSTIENTRRHIGKGEKFVVPTDQLQLYYLPSFPPYSRSYSGNRLGSKTFKPRKHIPDDDRQHEILQDAVATLDSGDLRLAVRLPEGEDLHEWIAFNTVEFFNQINMLYGTLLEFCTEESCPVMSAGPKYEYHWADGQLVKKPVKCSAPHYVNCLMVWIQRQLENEAIFPSKIGAPFPRDFISVVKVILKRLFRVYAHVYHAHFADVRELQEEAHLNTSFKHFIFFVLEFDLVQKRELVPLQQLIDILTANEQSTTSDGRSPVSDRHQPPQENKSSVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Z4</accession>
    <name>A0A074Z2Z4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4550 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">T265_11437</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597121">
        <property type="protein sequence ID" value="KER19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Z4"/>
    <dbReference type="STRING" id="6198.A0A074Z2Z4"/>
    <dbReference type="GeneID" id="20325605"/>
    <dbReference type="KEGG" id="ovi:T265_11437"/>
    <dbReference type="CTD" id="20325605"/>
    <dbReference type="OrthoDB" id="188352at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027876">
        <property type="entry name" value="DUF4550"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15084">
        <property type="entry name" value="DUF4550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4550" evidence="2">
        <location>
            <begin position="115"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="878" mass="99261" checksum="A2B817DA93AC5D64" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4P2</accession>
    <name>A0A074Z4P2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604857">
        <property type="protein sequence ID" value="KER18270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177983.1">
        <property type="nucleotide sequence ID" value="XM_009179719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4P2"/>
    <dbReference type="GeneID" id="20326493"/>
    <dbReference type="KEGG" id="ovi:T265_12325"/>
    <dbReference type="CTD" id="20326493"/>
    <dbReference type="OrthoDB" id="6239126at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="19060" checksum="2DA73E0E85CC7F8F" modified="2014-10-01" version="1">MIPRERKDCATLLRDERSSRQKHNNITRKRRLDLMRELVRTYDARSYNELYKRLSVQDTDDIYAEYGPTWKETAEHSIANYCKEIILEQETMTFEQILTSNHHSRTCQHPADTRQGEEWLDLLINVNHINKREIPHSSDEQIVYTKKRLRHRGTHNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5F4</accession>
    <name>A0A074Z5F4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ion transport N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5F4"/>
    <dbReference type="GeneID" id="20323700"/>
    <dbReference type="KEGG" id="ovi:T265_09531"/>
    <dbReference type="CTD" id="20323700"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ion transport N-terminal" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22676" checksum="2BB71EB15E720C60" modified="2014-10-01" version="1">MASIQVCQVKHESPHLSDTRSNTRLHRNFNFEDDSQPSPTSRQKGNLLKLTQEAVRMPFSLLRPRGYSSAFLDQVPSCVEDVHTSQKRRFTINLSESPCDEVEHRFLKHLETDSSKVGIGGDNSILQEIRENSWPDAQRERSWSAVHLKEQFIGFFQPANNRLAMKLFGNKVALACERRRQREQGKWVIHPCSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5V4</accession>
    <name>A0A074Z5V4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173804.1">
        <property type="nucleotide sequence ID" value="XM_009175540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5V4"/>
    <dbReference type="GeneID" id="20323634"/>
    <dbReference type="KEGG" id="ovi:T265_09465"/>
    <dbReference type="CTD" id="20323634"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8137" checksum="73A65098915C2B2E" modified="2014-10-01" version="1">MLFSKYKSSRPVGGSATAASMDEDPDSQITQVGRNGPITQSMTLVYRSFRSKRDELDTLVGGVANNEEQWGPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6D4</accession>
    <name>A0A074Z6D4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597896">
        <property type="protein sequence ID" value="KER18805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177448.1">
        <property type="nucleotide sequence ID" value="XM_009179184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6D4"/>
    <dbReference type="GeneID" id="20329982"/>
    <dbReference type="KEGG" id="ovi:T265_15817"/>
    <dbReference type="CTD" id="20329982"/>
    <dbReference type="OrthoDB" id="6224156at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10553" checksum="B5646DD6242C093E" modified="2014-10-01" version="1" fragment="single">MTFEEQCGWGLSLDMPARRGYRGRLGRPNDSQLNTSYPLPACCDSCRKCDELCDGEDSFFRHPDTDDSFLCTWCKKEYPLILAASCGHQFCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Q6</accession>
    <name>A0A074Z6Q6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173403.1">
        <property type="nucleotide sequence ID" value="XM_009175139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Q6"/>
    <dbReference type="STRING" id="6198.A0A074Z6Q6"/>
    <dbReference type="GeneID" id="20323321"/>
    <dbReference type="KEGG" id="ovi:T265_09142"/>
    <dbReference type="CTD" id="20323321"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="776" mass="85821" checksum="3902AAFB2217CBAE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z708</accession>
    <name>A0A074Z708_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596875">
        <property type="protein sequence ID" value="KER22878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173379.1">
        <property type="nucleotide sequence ID" value="XM_009175115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z708"/>
    <dbReference type="GeneID" id="20328928"/>
    <dbReference type="KEGG" id="ovi:T265_14762"/>
    <dbReference type="CTD" id="20328928"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="315" mass="35070" checksum="10DD02BF3B533152" modified="2014-10-01" version="1" fragment="single">MKSSECSYLCSCSGGCQHRLCALEQRRLENDRRFEDVYPEGSRRDEKIALDNSPSPCHYASLIDSSCICRVNGDVWCDVTQNIGPNVLLDYQFVLRYDSGELISVVQLLTENLVNSELQYLNSLISIGRLLVDILRNSTGDRDCGLVLNEHRIEADASHGASTPRLLGGADAPDSSDRGKTGYLVYAIITRPSLLIDWQSAHTNRDSDQDARSLCVQSLKLLELMVNRRYGEIRFPAVLSVLKRADIVFRSKSTGTTSAHERPAVSLLDSVADDRQNVNQATWRHPRTSVAKPSGLSHRSNRGNTQSFRSCTLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7P4</accession>
    <name>A0A074Z7P4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">T265_15051</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="KL596954">
        <property type="protein sequence ID" value="KER21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174649.1">
        <property type="nucleotide sequence ID" value="XM_009176385.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z7P4"/>
    <dbReference type="GeneID" id="20329217"/>
    <dbReference type="KEGG" id="ovi:T265_15051"/>
    <dbReference type="CTD" id="20329217"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05748">
        <property type="entry name" value="Ig_Titin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000321">
        <property type="entry name" value="Bent, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000160">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000050">
        <property type="entry name" value="Titin isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000003">
        <property type="entry name" value="Titin isoform E"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000127">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000056">
        <property type="entry name" value="twitchin isoform X4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="57"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF151">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="17" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="23" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="28">
        <location>
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            <end position="194"/>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
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                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="758" mass="84522" checksum="22F2BEE3ED319069" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z850</accession>
    <name>A0A074Z850_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_15019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596944">
        <property type="protein sequence ID" value="KER21727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174511.1">
        <property type="nucleotide sequence ID" value="XM_009176247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z850"/>
    <dbReference type="STRING" id="6198.A0A074Z850"/>
    <dbReference type="GeneID" id="20329185"/>
    <dbReference type="KEGG" id="ovi:T265_15019"/>
    <dbReference type="CTD" id="20329185"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="157"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER21727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="698" mass="78034" checksum="84435126E964F7E5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Z8</accession>
    <name>A0A074Z8Z8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172606.1">
        <property type="nucleotide sequence ID" value="XM_009174342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8Z8"/>
    <dbReference type="STRING" id="6198.A0A074Z8Z8"/>
    <dbReference type="GeneID" id="20328757"/>
    <dbReference type="KEGG" id="ovi:T265_14591"/>
    <dbReference type="CTD" id="20328757"/>
    <dbReference type="OrthoDB" id="6275914at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20939" checksum="DA9C41B6B6A69828" modified="2014-10-01" version="1">MDSFIDIFVSIDKDGTNVITYPELEQYVAENKLDPSMIEKWKQLFDPDNTGSITIESFCDKLGLKPAEITDFREHKDLHAAPPSLPPEIVVISANMSLEDQIKIARETIQIAPGAQTSEELGRLTENLKSFADKTFGGCWQVMVVDGSYWITQTFIPNMSFQFELYNRAYLFWQTSEDEVVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9E7</accession>
    <name>A0A074Z9E7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172523.1">
        <property type="nucleotide sequence ID" value="XM_009174259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9E7"/>
    <dbReference type="STRING" id="6198.A0A074Z9E7"/>
    <dbReference type="GeneID" id="20322631"/>
    <dbReference type="KEGG" id="ovi:T265_08452"/>
    <dbReference type="CTD" id="20322631"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="7">
        <location>
            <begin position="46"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="276"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57919" checksum="A615DFA7D8857D41" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA36</accession>
    <name>A0A074ZA36_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596827">
        <property type="protein sequence ID" value="KER23988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172244.1">
        <property type="nucleotide sequence ID" value="XM_009173980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA36"/>
    <dbReference type="GeneID" id="20322412"/>
    <dbReference type="KEGG" id="ovi:T265_08233"/>
    <dbReference type="CTD" id="20322412"/>
    <dbReference type="OrthoDB" id="6134060at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36085" checksum="1C87B9C6E9A2B592" modified="2014-10-01" version="1">MKATTNGLGAIGGERLISTKDIKKRTLKEQYEAVKRKTVLSHVMKYGDMDVTRDNFVKVLKGDKKLESNEKKVLRSGPDDNVFIFFSGFGTTSYIAFLGGYMNAMELNDTLAYMHSKKKFNKLVLYVESCKSGSMFKDVLPSNMGIYVTTSAKEDEQSWAVFCFDSKIDVCMGNEYSYEWITDSEQNDIKKRTLKEQYEAVKRKTVLSHVMKYGDMTMESLPVGKFQGHYDQLLHRNGTIAAENEEEHEAARRRLHRALQLGHIVKETFRNIVMDVTTHHKPTIKGLSKRDELMCFRAVFDQFRTHCFTIQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAC3</accession>
    <name>A0A074ZAC3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172021.1">
        <property type="nucleotide sequence ID" value="XM_009173757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAC3"/>
    <dbReference type="GeneID" id="20322241"/>
    <dbReference type="KEGG" id="ovi:T265_08062"/>
    <dbReference type="CTD" id="20322241"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10921" checksum="8B15C3FDD2085B4F" modified="2014-10-01" version="1">MYRGCYMRWLALEVKKSRYLRTHLQIHLVFTRDSTESLVYDILQLNVLHTSRLMFQLNLSSSTLPISSSPVVALAWPRAAYASRPTSSKGPSCTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAE2</accession>
    <name>A0A074ZAE2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597083">
        <property type="protein sequence ID" value="KER20175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176074.1">
        <property type="nucleotide sequence ID" value="XM_009177810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAE2"/>
    <dbReference type="STRING" id="6198.A0A074ZAE2"/>
    <dbReference type="GeneID" id="20325380"/>
    <dbReference type="KEGG" id="ovi:T265_11212"/>
    <dbReference type="CTD" id="20325380"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="590" mass="66046" checksum="E7580E712EB97A88" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBP3</accession>
    <name>A0A074ZBP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase, E subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_07698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171550.1">
        <property type="nucleotide sequence ID" value="XM_009173286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBP3"/>
    <dbReference type="STRING" id="6198.A0A074ZBP3"/>
    <dbReference type="GeneID" id="20321877"/>
    <dbReference type="KEGG" id="ovi:T265_07698"/>
    <dbReference type="CTD" id="20321877"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005722">
        <property type="entry name" value="PRK07539.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33232" checksum="6FCB6B6F6FCAE72F" modified="2014-10-01" version="1">MDESSRWQDYYPAPKGERKLLNGKSKPGPGRLGEGLHPHRDTPDNNPSIPFEFTEENKKRLDSIIACYPSAHKAAAMIPALDLAQRQHGWLPISAMNKVAEILGVPPMRVYEVATFYTMFNRQPVGKFHVQLCTTTPCMLGGVGSDLILDTIQKHLGIKAGQTTKDNLFTLTEVECLGACTNAPMMQINDDYYEDLTADDTIRILDELKAGKKPKKGPQSGQGGRFASEPKGGLTSLTTEPPGPGFKVRADFCSTLLVPSCRATRRLHEGWDTVRLPKPRQGKSSGRGRVRTTDLPVSKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBW2</accession>
    <name>A0A074ZBW2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596797">
        <property type="protein sequence ID" value="KER24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171452.1">
        <property type="nucleotide sequence ID" value="XM_009173188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBW2"/>
    <dbReference type="GeneID" id="20321799"/>
    <dbReference type="KEGG" id="ovi:T265_07620"/>
    <dbReference type="CTD" id="20321799"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF87">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="92"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="322"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="892" mass="104061" checksum="6172BF3C6322AAB4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCF3</accession>
    <name>A0A074ZCF3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein FAM76A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171395.1">
        <property type="nucleotide sequence ID" value="XM_009173131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCF3"/>
    <dbReference type="GeneID" id="20321753"/>
    <dbReference type="KEGG" id="ovi:T265_07574"/>
    <dbReference type="CTD" id="20321753"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67424" checksum="8B2E71E87540271E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD19</accession>
    <name>A0A074ZD19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596845">
        <property type="protein sequence ID" value="KER23547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172704.1">
        <property type="nucleotide sequence ID" value="XM_009174440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD19"/>
    <dbReference type="GeneID" id="20322767"/>
    <dbReference type="KEGG" id="ovi:T265_08588"/>
    <dbReference type="CTD" id="20322767"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11941" checksum="69808546C29ECDAD" modified="2014-10-01" version="1">MNFAEFAIKHASVFDPMLDNLITTVGQWPFFRSIRILKKPPKRFLRQMLPSVESTITAPPATLPTEGGTRTWILPGRPSLDRNSRDSEVGFEQQAFRSVSRSLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD67</accession>
    <name>A0A074ZD67_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171064.1">
        <property type="nucleotide sequence ID" value="XM_009172800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD67"/>
    <dbReference type="STRING" id="6198.A0A074ZD67"/>
    <dbReference type="GeneID" id="20321492"/>
    <dbReference type="KEGG" id="ovi:T265_07313"/>
    <dbReference type="CTD" id="20321492"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011332405" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="532" mass="60632" checksum="84EBE8697F333066" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDE6</accession>
    <name>A0A074ZDE6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170917.1">
        <property type="nucleotide sequence ID" value="XM_009172653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDE6"/>
    <dbReference type="GeneID" id="20321376"/>
    <dbReference type="KEGG" id="ovi:T265_07197"/>
    <dbReference type="CTD" id="20321376"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8448" checksum="54321D3B00ECE0E4" modified="2014-10-01" version="1">MAIQTCVEEADRVDMEGTQEKILAPFRSTAVVKIEGSTRNELLLSCSHLDRCNRKAEIGFEQWTFRSQASPFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDZ3</accession>
    <name>A0A074ZDZ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596832">
        <property type="protein sequence ID" value="KER23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172401.1">
        <property type="nucleotide sequence ID" value="XM_009174137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDZ3"/>
    <dbReference type="STRING" id="6198.A0A074ZDZ3"/>
    <dbReference type="GeneID" id="20322540"/>
    <dbReference type="KEGG" id="ovi:T265_08361"/>
    <dbReference type="CTD" id="20322540"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705408" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="94"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="518" mass="59159" checksum="13F18430A91CF536" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI37</accession>
    <name>A0A074ZI37_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trs120/TRAPPC9 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NIBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169276.1">
        <property type="nucleotide sequence ID" value="XM_009171012.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZI37"/>
    <dbReference type="GeneID" id="20320065"/>
    <dbReference type="KEGG" id="ovi:T265_05883"/>
    <dbReference type="CTD" id="20320065"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="108"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2024" mass="223794" checksum="52B84F78235F7FCC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ08</accession>
    <name>A0A074ZJ08_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169278.1">
        <property type="nucleotide sequence ID" value="XM_009171014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ08"/>
    <dbReference type="GeneID" id="20320067"/>
    <dbReference type="KEGG" id="ovi:T265_05885"/>
    <dbReference type="CTD" id="20320067"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704182" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24911" checksum="27F7618F88F1CA48" modified="2014-10-01" version="1">MFISTILLLLLIPHYHSTPIRDYADVYYSCTNLGDVISVCCCFRGWRGYPVFPRLSGFDVAAQRLKRRPADRKIRGSNPTSASRPLFGQPGTRASFGCNTLLVPSCHATQRKHEGWDTAQGCPSLDRGSRQAEVGFESRTFRSVNSRSNHLSHLALINYGADVTSGYLSMVESKTLRCVPYGCIGDKHGRCALRAISDFEPLCEPDENVESTVPKSSTSSSAVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ10</accession>
    <name>A0A074ZJ10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168972.1">
        <property type="nucleotide sequence ID" value="XM_009170708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ10"/>
    <dbReference type="STRING" id="6198.A0A074ZJ10"/>
    <dbReference type="GeneID" id="20327994"/>
    <dbReference type="KEGG" id="ovi:T265_13827"/>
    <dbReference type="CTD" id="20327994"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16182">
        <property type="entry name" value="EFh_PEF_Group_II_CAPN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="49"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="703" mass="80389" checksum="45A7663011EADA4B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ25</accession>
    <name>A0A074ZJ25_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170512.1">
        <property type="nucleotide sequence ID" value="XM_009172248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ25"/>
    <dbReference type="GeneID" id="20321045"/>
    <dbReference type="KEGG" id="ovi:T265_06866"/>
    <dbReference type="CTD" id="20321045"/>
    <dbReference type="OrthoDB" id="6244438at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="298" mass="32917" checksum="0D3F29551F9440CF" modified="2014-10-01" version="1">MFVSKPNCLDPLWIDMSPTALELILRISISKLQILRNSMQPTAELTVLRMTSYGEKPVVAENSKHDVHQPNLNKEPVRARFRQRTVSNGLFRSLMITIIGKKARSVLVHEQMRNKSAVDVHQIPIRNVTPYASISKASGSPMSYSEVDRKISRFSVPVPCEANLTTSSSADYLNQNPTRPTECPKRPGVLLTDVSTTKPKQFKWDTPIVLNLPQEKRIGEICQNLALTKPKPAEANDTLFLSESSEPLDESICFGIIRPGNPPLQLPGDNSVAKHTGSGDIRLAVLDGVSLMLVDGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKR4</accession>
    <name>A0A074ZKR4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168342.1">
        <property type="nucleotide sequence ID" value="XM_009170078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKR4"/>
    <dbReference type="GeneID" id="20327857"/>
    <dbReference type="KEGG" id="ovi:T265_13690"/>
    <dbReference type="CTD" id="20327857"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8793" checksum="F837E3D081BB5D09" modified="2014-10-01" version="1" fragment="single">MMKSSAETSMAMYGDMQQSVQYAVHAWRPAIPNNRTSHRLDECVTCRTQTKRRYALIGQNASQSRSSTFNSTHPAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLY7</accession>
    <name>A0A074ZLY7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169507.1">
        <property type="nucleotide sequence ID" value="XM_009171243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLY7"/>
    <dbReference type="GeneID" id="20328106"/>
    <dbReference type="KEGG" id="ovi:T265_13939"/>
    <dbReference type="CTD" id="20328106"/>
    <dbReference type="OrthoDB" id="10640287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="23968" checksum="F39A80E0C9C9AB6F" modified="2014-10-01" version="1" fragment="single">GLPPEGDTKGEVLLGCPSVNRGSGESGVRISNPTLPFDIRDCPTYASLEVPYREPQQKLPTRKVCHAGASQLETQSYYYQAEQFYLHMVAQLETEAEFVSSNLASQSFVFVLDVFRILDCRLSSGVTTPFRCQTVMPPEGLSFLREHESWDTVRLPEPRQDKSSHGGRVRTSDLPAKNLPKSGIELLSSNDQRNENNKRFRAISMIFSPKCDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLZ2</accession>
    <name>A0A074ZLZ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_07943</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171872.1">
        <property type="nucleotide sequence ID" value="XM_009173608.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLZ2"/>
    <dbReference type="GeneID" id="20322122"/>
    <dbReference type="KEGG" id="ovi:T265_07943"/>
    <dbReference type="CTD" id="20322122"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000414">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="18">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="19">
        <location>
            <begin position="702"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER24385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1355" mass="154341" checksum="177600A72BFDF90A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMK7</accession>
    <name>A0A074ZMK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169219.1">
        <property type="nucleotide sequence ID" value="XM_009170955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMK7"/>
    <dbReference type="GeneID" id="20320016"/>
    <dbReference type="KEGG" id="ovi:T265_05834"/>
    <dbReference type="CTD" id="20320016"/>
    <dbReference type="OrthoDB" id="6247291at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="585" mass="65312" checksum="EBDB8286DB53C0AA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMM6</accession>
    <name>A0A074ZMM6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167876.1">
        <property type="nucleotide sequence ID" value="XM_009169612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMM6"/>
    <dbReference type="GeneID" id="20327757"/>
    <dbReference type="KEGG" id="ovi:T265_13590"/>
    <dbReference type="CTD" id="20327757"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10711" checksum="811423B9FC1DC3ED" modified="2014-10-01" version="1" fragment="single">NTSLLPSLPVNDADFSGSVIIDADLRTPKETAFDSGLCADPALQASRLLFWSYRHYERSGTEVEDPFAHNAQLGWSGQWPNRSSIARITTGQSMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN51</accession>
    <name>A0A074ZN51_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009173249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN51"/>
    <dbReference type="STRING" id="6198.A0A074ZN51"/>
    <dbReference type="GeneID" id="20328512"/>
    <dbReference type="KEGG" id="ovi:T265_14346"/>
    <dbReference type="CTD" id="20328512"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000003">
        <property type="entry name" value="Pre-mRNA processing factor 40 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="782" mass="90545" checksum="6735A99A1FA0DE29" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNA7</accession>
    <name>A0A074ZNA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169021.1">
        <property type="nucleotide sequence ID" value="XM_009170757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNA7"/>
    <dbReference type="GeneID" id="20319870"/>
    <dbReference type="KEGG" id="ovi:T265_05688"/>
    <dbReference type="CTD" id="20319870"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="7029" checksum="290FBBE914965173" modified="2014-10-01" version="1">MESWFYESHLNVVLGFTGQELSRALIPKSRNMFRRCFNPHLEQEGYSDEITNDTAWSCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNS1</accession>
    <name>A0A074ZNS1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171284.1">
        <property type="nucleotide sequence ID" value="XM_009173020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNS1"/>
    <dbReference type="GeneID" id="20321666"/>
    <dbReference type="KEGG" id="ovi:T265_07487"/>
    <dbReference type="CTD" id="20321666"/>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="16274" checksum="7010BEC4B9501060" modified="2014-10-01" version="1">MYSPDRNQIDFFQPPTSLDSPLTVLDLCTNLSPPACSGQLPTPYPQIIGERNCGSYNHCTTSSRLLQLMLLMIQSSHQSDTEEHHGAEIYTNFTLSETPIRNRTSMPPEGSTKAGIPPGCPSLDRGGREADVGLEPRTFQSINSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNS3</accession>
    <name>A0A074ZNS3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167188.1">
        <property type="nucleotide sequence ID" value="XM_009168924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNS3"/>
    <dbReference type="GeneID" id="20318417"/>
    <dbReference type="KEGG" id="ovi:T265_04231"/>
    <dbReference type="CTD" id="20318417"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11746" checksum="7D65FF14F02B8E29" modified="2014-10-01" version="1">MYFTRTLSSSDGTSNHSSEYFHQPQKKRNSEWYGEIDNNSLTTDYRFCFWILSFILNQLLYINQTGMDGSAWEKQGAKARSINFIQMTIYSPPLPLLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX3</accession>
    <name>A0A074ZPX3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03939</name>
        <name evidence="3" type="ORF">T265_03940</name>
        <name evidence="4" type="ORF">T265_03941</name>
        <name evidence="5" type="ORF">T265_03942</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168541.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPX3"/>
    <dbReference type="GeneID" id="20318125"/>
    <dbReference type="GeneID" id="20318126"/>
    <dbReference type="GeneID" id="20318127"/>
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    <dbReference type="KEGG" id="ovi:T265_03939"/>
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    <dbReference type="CTD" id="20318125"/>
    <dbReference type="CTD" id="20318126"/>
    <dbReference type="CTD" id="20318127"/>
    <dbReference type="CTD" id="20318128"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="16647" checksum="DF3F37C7DB415732" modified="2014-10-01" version="1">MTSAKTPSYENNDQCSILPNPQRDSRRLAQNSGCNTHTAPNAANTRIPHEEKTIYPQPKQSVEYKQQSLHNQYHKQPKPHTNTKPTASDTHNQSSHMAKQQTHSTRPQCQTTTQTNQITSIKHHQSSISNTRHSKPTISISPQTEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ10</accession>
    <name>A0A074ZQ10_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009172545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ10"/>
    <dbReference type="GeneID" id="20321281"/>
    <dbReference type="KEGG" id="ovi:T265_07102"/>
    <dbReference type="CTD" id="20321281"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="23180" checksum="92577CC7E9C7D893" modified="2014-10-01" version="1">MKNFRKTSQLISFYKSANQMSFRKRSDCSKEALMVSVPHVYVDGAKWLEFTDRKFHVSNPTSASRLPLSELRQPRSIPALEFPSDGMVARHRKDVTAERLRLFITCLRLMIWWLIRWMQFPSTLRFTVEPNRAAFDKETHLRVAENSSTAHERREFHAIWFRVEQKVDGNSRLCLPYEPQEGRNRSWTVEEFSAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ45</accession>
    <name>A0A074ZQ45_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER29191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ45"/>
    <dbReference type="STRING" id="6198.A0A074ZQ45"/>
    <dbReference type="GeneID" id="20318312"/>
    <dbReference type="KEGG" id="ovi:T265_04126"/>
    <dbReference type="CTD" id="20318312"/>
    <dbReference type="OrthoDB" id="6281719at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704281" evidence="2">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="216" mass="22084" checksum="C6EF2EAD48449FC2" modified="2014-10-01" version="1">MTSMLLLFLVLTSWLQAGSSQETSEPLPSDNITTAKDDSSEVAQTSAIDGATSTVTAVQETTQKMSDPATEPQGTTLQVDAQDSSTSSAAHVSSVAAADETTQVSTADPTQTTAAGEVSTENSVQETATKMPEFASTESSSVITTQADAKGSATQAPDGQNTMDTATPGKNGGVTPGTSATPKTTKSGVDRTRKGLSNWLFTSALCFVGSYGIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS76</accession>
    <name>A0A074ZS76_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166242.1">
        <property type="nucleotide sequence ID" value="XM_009167978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS76"/>
    <dbReference type="GeneID" id="20317665"/>
    <dbReference type="KEGG" id="ovi:T265_03478"/>
    <dbReference type="CTD" id="20317665"/>
    <dbReference type="OrthoDB" id="10018421at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="13039" checksum="865E068CA8815773" modified="2014-10-01" version="1">MSNSCDQFNLLNLYVLCHLSPLNLWIHRRNYNAKIGADHATRYQIEHMGTTCGRHFTIETGENKKFASLDVLVTRTTNGQLQTEVYRKEKHRDQILNYHSNHPKCHRRSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS99</accession>
    <name>A0A074ZS99_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167580.1">
        <property type="nucleotide sequence ID" value="XM_009169316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS99"/>
    <dbReference type="STRING" id="6198.A0A074ZS99"/>
    <dbReference type="GeneID" id="20318734"/>
    <dbReference type="KEGG" id="ovi:T265_04552"/>
    <dbReference type="CTD" id="20318734"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="69"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="675" mass="75516" checksum="83B87F4B5DA8617A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSF9</accession>
    <name>A0A074ZSF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169935.1">
        <property type="nucleotide sequence ID" value="XM_009171671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSF9"/>
    <dbReference type="GeneID" id="20320592"/>
    <dbReference type="KEGG" id="ovi:T265_06413"/>
    <dbReference type="CTD" id="20320592"/>
    <dbReference type="OrthoDB" id="6234005at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER26295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="409" mass="47325" checksum="DAD92C75135A337E" modified="2014-10-01" version="1">MIKHTTVQRETHSPKDLSRQNKSLDVKDARWKALRELDGWNFDGDRLKAINCDAMSIAASKFKRISFRKYDWFGNQLFSYGKEVDIFRQICHFRRGSLVSHTLHQQSRTIPMLINFPKLCEVTDNERGTLDLLILIKSRNTHYSLREAIRKTWGNDMCWLGKTVRHVFVLGKHNDSKEQERIVQEAKYHGDIIQRDFIDHYSNNTYKTMFAFQWAIAYCPEAPIYLFVDDDFFVSPVEVVAFLEKLDPWIVQHQIVGSQILMSRVVRNGTGPSKWALSKAVYPNAYYPNYVSGGFYMIGRELALDLYIATQFTGFLPIDDAYLGLALNKLLVQMGHKNYIHMGGKRKMLKSHFERFLGLHGYHTASRQRLTWKLVVPKTVCSTSLPDKASGMISPIRRMGNKNDIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSJ1</accession>
    <name>A0A074ZSJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605573">
        <property type="protein sequence ID" value="KER18234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178019.1">
        <property type="nucleotide sequence ID" value="XM_009179755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSJ1"/>
    <dbReference type="STRING" id="6198.A0A074ZSJ1"/>
    <dbReference type="GeneID" id="20330369"/>
    <dbReference type="KEGG" id="ovi:T265_16204"/>
    <dbReference type="CTD" id="20330369"/>
    <dbReference type="OrthoDB" id="10028852at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7788" checksum="655912FE96A4880C" modified="2014-10-01" version="1" fragment="single">MSNEGAYLSFKRAFDEQRCEIQRLYDRVAKLEEANSKVLTYVKQTGNLPLLDGGTIKCQVTPDAHPQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSQ4</accession>
    <name>A0A074ZSQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167406.1">
        <property type="nucleotide sequence ID" value="XM_009169142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSQ4"/>
    <dbReference type="GeneID" id="20318585"/>
    <dbReference type="KEGG" id="ovi:T265_04403"/>
    <dbReference type="CTD" id="20318585"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16354" checksum="3667A0D177CC59B8" modified="2014-10-01" version="1">MARLLFKDFLLTPSIIVFYILLSTLREHTTFLSFLGISSMTWRRRTIDDITPVPVDSVEGRRGADTYVVLNSGIHLDSNFEVHLDPICVYFKDPAALGRVPSNMQEEAILLKKYVIILNLEDPCSDGDYVVPMKNLKFTGETQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSS1</accession>
    <name>A0A074ZSS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_13488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167367.1">
        <property type="nucleotide sequence ID" value="XM_009169103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSS1"/>
    <dbReference type="STRING" id="6198.A0A074ZSS1"/>
    <dbReference type="GeneID" id="20327655"/>
    <dbReference type="KEGG" id="ovi:T265_13488"/>
    <dbReference type="CTD" id="20327655"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="125"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER28882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1151" mass="125503" checksum="A41A8D364D56AA51" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSY6</accession>
    <name>A0A074ZSY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_12290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KL602046">
        <property type="protein sequence ID" value="KER18384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177869.1">
        <property type="nucleotide sequence ID" value="XM_009179605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSY6"/>
    <dbReference type="STRING" id="6198.A0A074ZSY6"/>
    <dbReference type="GeneID" id="20326458"/>
    <dbReference type="KEGG" id="ovi:T265_12290"/>
    <dbReference type="CTD" id="20326458"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER18384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25075" checksum="DB4DF4D2A0B01F26" modified="2014-10-01" version="1">MQLLAGIQVLSVGDTPKDRALFNGAQKLFGMVITIGQASVYVMSGIYGAPSELGAGICLIIIFQLTFAGLLVLMLDELLQKGYGLGSGISLFIATNICETIVWRAISPTTINTGRGKFASRIVQMDSGTEFEGAIISLFHLLATRTDKVRALREAFYRQNLPNLMNILATVLSFRVDIAVKSIRYRGQSSSYPIKLFYTSNAPIMLQSALVSNLYVMSQVSSFHRVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW0</accession>
    <name>A0A074ZTW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169454.1">
        <property type="nucleotide sequence ID" value="XM_009171190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW0"/>
    <dbReference type="STRING" id="6198.A0A074ZTW0"/>
    <dbReference type="GeneID" id="20320213"/>
    <dbReference type="KEGG" id="ovi:T265_06031"/>
    <dbReference type="CTD" id="20320213"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10471" checksum="709BEA3757304831" modified="2014-10-01" version="1">MAVDRGQWRSYCQFLFRLPELISGDRHPHCPLVLIKQSDAPNIVWSSSASKLSRVGNCHLPVWGPRDSTCQWLTALAVMAQSYSQWRSKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU35</accession>
    <name>A0A074ZU35_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169374.1">
        <property type="nucleotide sequence ID" value="XM_009171110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU35"/>
    <dbReference type="GeneID" id="20320145"/>
    <dbReference type="KEGG" id="ovi:T265_05963"/>
    <dbReference type="CTD" id="20320145"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="23558" checksum="CDCA65DC41926441" modified="2014-10-01" version="1">MGQENSSLHSRLQIRGAVNISSIFYEEANPSWAKIESLHEGSGGNKNLSQTAVPKSVVVFPMHHHIGAELSRIAEISGSNQRYLQCIFNSTNGKSSSVYLFTTAVYKVYSSNLASLSVYARQPIIFIYEYSTVKVPNKMESWIRRRLTAQNVLRLQVVFLHFPLLQWSVKSLMKLLARIMLLKSAGFMTDLDSERLVKEIWIHEHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVT2</accession>
    <name>A0A074ZVT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168760.1">
        <property type="nucleotide sequence ID" value="XM_009170496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVT2"/>
    <dbReference type="STRING" id="6198.A0A074ZVT2"/>
    <dbReference type="GeneID" id="20327942"/>
    <dbReference type="KEGG" id="ovi:T265_13775"/>
    <dbReference type="CTD" id="20327942"/>
    <dbReference type="OrthoDB" id="6627613at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="408"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="592" mass="66794" checksum="57F67D83DAB7B5B7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWX1</accession>
    <name>A0A074ZWX1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_02125</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164563.1">
        <property type="nucleotide sequence ID" value="XM_009166299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWX1"/>
    <dbReference type="STRING" id="6198.A0A074ZWX1"/>
    <dbReference type="GeneID" id="20316313"/>
    <dbReference type="KEGG" id="ovi:T265_02125"/>
    <dbReference type="CTD" id="20316313"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="307"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="659" mass="74310" checksum="22D62938DFBC5830" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXC0</accession>
    <name>A0A074ZXC0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165701.1">
        <property type="nucleotide sequence ID" value="XM_009167437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXC0"/>
    <dbReference type="GeneID" id="20317235"/>
    <dbReference type="KEGG" id="ovi:T265_03048"/>
    <dbReference type="CTD" id="20317235"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10544" checksum="4DDDAD224F64A687" modified="2014-10-01" version="1">MDRPGKTVAISTVVQTSSKTSNLELEFGCEPTKPQPNSQWKQLSPEVCHPRFAASAPNSPYDMIFGMALLRHYATILAINHLKTHLKDVKYCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXJ3</accession>
    <name>A0A074ZXJ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168140.1">
        <property type="nucleotide sequence ID" value="XM_009169876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXJ3"/>
    <dbReference type="GeneID" id="20319168"/>
    <dbReference type="KEGG" id="ovi:T265_04986"/>
    <dbReference type="CTD" id="20319168"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12853" checksum="CE6E4F72636C1AF2" modified="2014-10-01" version="1">MTAGSRAIYPKNAEQRRRWMTETAKLYLKKSSNKPLRSCQNRFSIPRLPAGYPFLLYLADTRLKRIAALEIRASKMCEAMKNEVFAPLCIHTMFHIAAANEETMGFVRNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXV0</accession>
    <name>A0A074ZXV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_01686</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164016.1">
        <property type="nucleotide sequence ID" value="XM_009165752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXV0"/>
    <dbReference type="STRING" id="6198.A0A074ZXV0"/>
    <dbReference type="GeneID" id="20315874"/>
    <dbReference type="KEGG" id="ovi:T265_01686"/>
    <dbReference type="CTD" id="20315874"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="14">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="528" mass="59127" checksum="8DB94C3273F05D3E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYD7</accession>
    <name>A0A074ZYD7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167896.1">
        <property type="nucleotide sequence ID" value="XM_009169632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYD7"/>
    <dbReference type="STRING" id="6198.A0A074ZYD7"/>
    <dbReference type="GeneID" id="20318976"/>
    <dbReference type="KEGG" id="ovi:T265_04794"/>
    <dbReference type="CTD" id="20318976"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="862" mass="93942" checksum="B45EA38DD3B008AD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ27</accession>
    <name>A0A074ZZ27_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_11006</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KL597057">
        <property type="protein sequence ID" value="KER20444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175807.1">
        <property type="nucleotide sequence ID" value="XM_009177543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ27"/>
    <dbReference type="STRING" id="6198.A0A074ZZ27"/>
    <dbReference type="GeneID" id="20325174"/>
    <dbReference type="KEGG" id="ovi:T265_11006"/>
    <dbReference type="CTD" id="20325174"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000046">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER20444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="282" mass="31576" checksum="C27061B28277784B" modified="2014-10-01" version="1">MDQSASSQQQEYQYFMSQTGEAWDPETRSNQKLATGNACLLRITKDLRTIYSDPAPGIVVAPDEADLTKVHALITGPFDTPYEGGFFLFLIRFPPEYPLKPPRVKLMTTGNGTVRFNPNLYKNGKVCLSILGTWTGPEWTPAQSLWSVLVSIQSLMNDEPYYNEPGFRHEHSPGDSKRYNNIIQHETIRCAVCDVLEGRSWCPPDLLGVIQSSFEEYYDQYMEVCEKNAQLTGQPMNDPFGEQRGSFDFVTLSRRLKDIRAKLKRTSNAGGDAGSSGPNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ47</accession>
    <name>A0A074ZZ47_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyl-coenzyme A synthetase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163448.1">
        <property type="nucleotide sequence ID" value="XM_009165184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ47"/>
    <dbReference type="STRING" id="6198.A0A074ZZ47"/>
    <dbReference type="GeneID" id="20315387"/>
    <dbReference type="KEGG" id="ovi:T265_01199"/>
    <dbReference type="CTD" id="20315387"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="381" mass="42696" checksum="1B619EF197D17BDB" modified="2014-10-01" version="1">MTVLRPHQCYFHFYSPTLVYYPPRITNTRNLDARTWIVGNVRGGALPTENHVTAQSKSPDDVTDPIVGVCMADGTVLLMNPATEDEAERVLWCIQLHFRGELFGLSKVNLTRGHTDELCVCAWDGTTYVFNHRKQILRFPMGQSCQAFLAGWYAVEPGRNEPVFVYATCEHSLLIYHNLNVDHLVEPCLFHELSNDASIASSLQALQIDLPMSTTLWTPSSNSGISMLEFMHFVEQKHNLNFGGDYHKFYTWSIEQLNQFWLDFFFHACVRHSVPPTQAIDTTAKMSSIPKWFPDCRLNYAENILSGGKPPDVALLAFCAVTAEKPGPLEVRPEFATLAGPASRRDLIGQQSGPNSQSGPSIDQMPVANGAPEHVRNSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZI4</accession>
    <name>A0A074ZZI4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_01380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163670.1">
        <property type="nucleotide sequence ID" value="XM_009165406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZI4"/>
    <dbReference type="STRING" id="6198.A0A074ZZI4"/>
    <dbReference type="GeneID" id="20315568"/>
    <dbReference type="KEGG" id="ovi:T265_01380"/>
    <dbReference type="CTD" id="20315568"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="27"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="363" mass="40974" checksum="0CFEAEA71FDC2DDF" modified="2014-10-01" version="1">MGDDFTLADYVATLTMLGIVSVLGTIGNLLVVGVYLQHLLWPHLQRHFQKGYQINYSEKQCATLTASYDDATLTDQFCDRQMTTPTFFILVLAIVDLIVCCFVVPLAFYLEFVELKASSELWCKLHAFGSVCNTMFSSLLVIAIALDRYFAICHPLKNVLTMRRAKILTAALAIFCCVYGILSQDMMALDVGKLSNDNVPRCHDAIELANITSTKVYFYHIIQKGNSSCFVLSILVVLILYSLILRAALKAQRRIRNNALWREIRAAIVLFVVAVVYIIVFAPSLLSANHLIPGTLFGYNSYYLNNMSNPLIYCFMSQAFRRRLKVLLCSACINSVQSQDDAMFSRSGRRERIRRLMQTVEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0B0</accession>
    <name>A0A075A0B0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164605.1">
        <property type="nucleotide sequence ID" value="XM_009166341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0B0"/>
    <dbReference type="GeneID" id="20316355"/>
    <dbReference type="KEGG" id="ovi:T265_02167"/>
    <dbReference type="CTD" id="20316355"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="669" mass="75733" checksum="62608B63E74C311B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A174</accession>
    <name>A0A075A174_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162686.1">
        <property type="nucleotide sequence ID" value="XM_009164422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A174"/>
    <dbReference type="STRING" id="6198.A0A075A174"/>
    <dbReference type="GeneID" id="20314782"/>
    <dbReference type="KEGG" id="ovi:T265_00594"/>
    <dbReference type="CTD" id="20314782"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="22458" checksum="C525D89A3060930C" modified="2014-10-01" version="1">MYRTAYQSGLLSIFYSVGQKPLLNWAVSAKAGTVRRISDPDIRSLILDLRSSNVTTTYIECPSDPDETLGIRMPIFVLLFKNMNRYFSFQIEVTDYSGTRRRFRASNFNRVTSIRDFTTNMPLVLHPGWNTVVFDLQRLMEYCYRQRLLEVNRIRVNANCRLRRIYFCDRPYADSELPKEYKLQLVPSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1A2</accession>
    <name>A0A075A1A2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166966.1">
        <property type="nucleotide sequence ID" value="XM_009168702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1A2"/>
    <dbReference type="STRING" id="6198.A0A075A1A2"/>
    <dbReference type="GeneID" id="20318253"/>
    <dbReference type="KEGG" id="ovi:T265_04067"/>
    <dbReference type="CTD" id="20318253"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="260" mass="30143" checksum="EAF243794013E70C" modified="2014-10-01" version="1">MQKYNEPTILLSDLNDYITCRLCKGYLIDAVSITECLHPFCKSCIVKYLEERYDCPSCGILIHQSHPLNYISYDRTLQDIVYKVVPDLKRRKFNGFGLLRTTTGERQRRQDFYCSMGKSPPPSEELVRERLSPNGLDSSGDASTGQFSSPSASNLSHAPDYHRSDEQVNVHLEPGSDSLEPLTFKYLRLSSRATVTHLRKYVAQQVLHDISRFRDIDIFIQNNEDGTFLGRDHILKFVRVVYWNDDEPMPLQYRFNQTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M3</accession>
    <name>A0A075A1M3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PI31 proteasome regulator C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166791.1">
        <property type="nucleotide sequence ID" value="XM_009168527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M3"/>
    <dbReference type="STRING" id="6198.A0A075A1M3"/>
    <dbReference type="GeneID" id="20318113"/>
    <dbReference type="KEGG" id="ovi:T265_03926"/>
    <dbReference type="CTD" id="20318113"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="5">
        <location>
            <begin position="230"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="322" mass="34812" checksum="8E45EC264F407F28" modified="2014-10-01" version="1">MTGLPGDSGTKAGVTELSSLVANKPNSVEMSILELVHFIHHRDVTRRGQLISLLLHAQLLSRGARPTQSEGQSQFAVLAEEVLNSDPIRIPYTLVPRPKTETLATVASQLQLSVVETDAQIFISLTDTTTDKFGHVELSGLEHVRLDCVSECAAGHWNTVYPQLDELLSIFEESLWKAVLPSPPLNRFGETERKKDRRDPGPPPDDPQRYPPTGFDPVRPTAPGFPFPDYGRSDLDPFGSLGGRGGMILDPRRPLGGSPFGSGGGTFMGGPDVLPPGAVPPGARFDPFGPGVIPPRPRFSNPQRGQPDPDHALPPGFEDVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A205</accession>
    <name>A0A075A205_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162457.1">
        <property type="nucleotide sequence ID" value="XM_009164193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A205"/>
    <dbReference type="GeneID" id="20314608"/>
    <dbReference type="KEGG" id="ovi:T265_00420"/>
    <dbReference type="CTD" id="20314608"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="26239" checksum="08E478FC2DCB3CF7" modified="2014-10-01" version="1">MERKSEAVRHTGRLQLWKRHLDDKFIMAHKRSVEEGAFHVPSPIQDYSMVSEATLVIRRQSETMSHLIYRKTVVRTLQNTHISPPSVLEIGPDMPSKGVDLLALARGLQSGIMTPEQVLSLLDFHASRTFPYTGKLHPDAAVSRPIGCRSTESRSVGPTTPLSRLYTTKDEKVQRLVSPMGDGRIYTKMAKSQGSTTRLDLDRATYGRSSPLYDPLNGQFIPRPGQAHVKDAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A370</accession>
    <name>A0A075A370_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166267.1">
        <property type="nucleotide sequence ID" value="XM_009168003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A370"/>
    <dbReference type="STRING" id="6198.A0A075A370"/>
    <dbReference type="GeneID" id="20317690"/>
    <dbReference type="KEGG" id="ovi:T265_03503"/>
    <dbReference type="CTD" id="20317690"/>
    <dbReference type="OrthoDB" id="5873004at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="651"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="829"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127388" checksum="FADD51A7B65C589E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3B3</accession>
    <name>A0A075A3B3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase, T1 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163471.1">
        <property type="nucleotide sequence ID" value="XM_009165207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3B3"/>
    <dbReference type="STRING" id="6198.A0A075A3B3"/>
    <dbReference type="GeneID" id="20315410"/>
    <dbReference type="KEGG" id="ovi:T265_01222"/>
    <dbReference type="CTD" id="20315410"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18772" checksum="624F121D24394FF4" modified="2014-10-01" version="1">MYMHAHTLYSAIRPFGVSLLLGSCEEDGPHLYVVEPSGLSFAYRGCAIGKAKQNATTEIEKLKPMELSSNDLVKEAAKMFRLRTSGDAEAAAAAYAGVGSVLSEQAEASLLDWILVFSRLCAVRLAKSVRESRESEVHRTLFVVSAYAPTDCSPESAKDRLKAQISLWLLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3U6</accession>
    <name>A0A075A3U6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174186.1">
        <property type="nucleotide sequence ID" value="XM_009175922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3U6"/>
    <dbReference type="GeneID" id="20323919"/>
    <dbReference type="KEGG" id="ovi:T265_09751"/>
    <dbReference type="CTD" id="20323919"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9427" checksum="E622DA48CFFAF800" modified="2014-10-01" version="1">MTKYRLTRDSTLAIKNSIYFLSFIIYSGAAISRHHIQNKEHGFKVLGSTAFTSVDVAYIGLDRTSCNLGNLHLPILCLKPISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3W6</accession>
    <name>A0A075A3W6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166010.1">
        <property type="nucleotide sequence ID" value="XM_009167746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3W6"/>
    <dbReference type="STRING" id="6198.A0A075A3W6"/>
    <dbReference type="GeneID" id="20317487"/>
    <dbReference type="KEGG" id="ovi:T265_03300"/>
    <dbReference type="CTD" id="20317487"/>
    <dbReference type="OrthoDB" id="2339771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033471">
        <property type="entry name" value="DIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045831">
        <property type="entry name" value="LIN9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06584">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19438">
        <property type="entry name" value="LIN9_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01135">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIRP" evidence="5">
        <location>
            <begin position="59"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="672" mass="75559" checksum="F173AB4CBDA2C264" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4W3</accession>
    <name>A0A075A4W3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162991.1">
        <property type="nucleotide sequence ID" value="XM_009164727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4W3"/>
    <dbReference type="STRING" id="6198.A0A075A4W3"/>
    <dbReference type="GeneID" id="20326813"/>
    <dbReference type="KEGG" id="ovi:T265_12645"/>
    <dbReference type="CTD" id="20326813"/>
    <dbReference type="OrthoDB" id="447516at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="642" mass="70242" checksum="E8533AFF652ECF67" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A584</accession>
    <name>A0A075A584_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">Ribosomal protein L30p/L7e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A584"/>
    <dbReference type="STRING" id="6198.A0A075A584"/>
    <dbReference type="GeneID" id="20314948"/>
    <dbReference type="KEGG" id="ovi:T265_00760"/>
    <dbReference type="CTD" id="20314948"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF58">
        <property type="entry name" value="IP16805P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33793" checksum="A092FFF390F06A13" modified="2014-10-01" version="1">MAHLLTGRTVPPLKSAGFKPSLPAARAAPLDALLRRTSHRIRQLPSAMTEPEVQLKSLPVTLLKRRKRANKDIIKEQRERSEQLRKRAKLRRSQVRRPAFFIASARKKARDEMRLSRQAIRKSPVVATDAARLGVIIRLKREDEELSDDCRAVFRLLRLDTYNQAVFVKVNQAMLELLGLVAPYVAWGYPTLQTVRDLLAKRGRTFFNHRKHAIDNKIIESRLGHHGILCLEDVVHELVTIGPQLRAVLRFLQPFKLMPPSKSWLSGSKRCRSAADRLTGMREENINEMIRRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6X0</accession>
    <name>A0A075A6X0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162096.1">
        <property type="nucleotide sequence ID" value="XM_009163832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6X0"/>
    <dbReference type="GeneID" id="20326584"/>
    <dbReference type="KEGG" id="ovi:T265_12416"/>
    <dbReference type="CTD" id="20326584"/>
    <dbReference type="OrthoDB" id="6249047at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="18580" checksum="CE93A3ABC5873598" modified="2014-10-01" version="1" fragment="single">RVAGAVTSEGTEIPDDPTCSYESKYSKCCGSPTVTISSSSAETTVSVRRSPVRRVRPDAFRRTLRLRRRTCLFRLHVQNRPAPEMFDPVQAPNSSNPPTQFSNIRPYQLSLQDPTTGSQLSFETYLAQPVEIRYPFNYVADLFEDASPTSAQSRESSPFPPTELQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A758</accession>
    <name>A0A075A758_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161965.1">
        <property type="nucleotide sequence ID" value="XM_009163701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A758"/>
    <dbReference type="GeneID" id="20314232"/>
    <dbReference type="KEGG" id="ovi:T265_00044"/>
    <dbReference type="CTD" id="20314232"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="15211" checksum="29A5F7D7AEF0D666" modified="2014-10-01" version="1">MNAGRWTRGSYGSHCEFNRARRMPTSLPQENFYRIKKTDERDNVGRNLEYELIMLTFNSHAPVPYGLSGTLYCDQQALKDQLGCDLNWLIRNSAANQELSSPLTPSCKIRTVMDLTRRLRQLDYTQFAASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7A8</accession>
    <name>A0A075A7A8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 63 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162135.1">
        <property type="nucleotide sequence ID" value="XM_009163871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7A8"/>
    <dbReference type="STRING" id="6198.A0A075A7A8"/>
    <dbReference type="GeneID" id="20326623"/>
    <dbReference type="KEGG" id="ovi:T265_12455"/>
    <dbReference type="CTD" id="20326623"/>
    <dbReference type="OrthoDB" id="10007333at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="98150" checksum="BCBCF4AE6F72A1AE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7G5</accession>
    <name>A0A075A7G5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein bicaudal D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172867.1">
        <property type="nucleotide sequence ID" value="XM_009174603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7G5"/>
    <dbReference type="STRING" id="6198.A0A075A7G5"/>
    <dbReference type="GeneID" id="20322902"/>
    <dbReference type="KEGG" id="ovi:T265_08723"/>
    <dbReference type="CTD" id="20322902"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="673"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122904" checksum="42ADED8947B833AD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A882</accession>
    <name>A0A075A882_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164324.1">
        <property type="nucleotide sequence ID" value="XM_009166060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A882"/>
    <dbReference type="GeneID" id="20327053"/>
    <dbReference type="KEGG" id="ovi:T265_12885"/>
    <dbReference type="CTD" id="20327053"/>
    <dbReference type="OrthoDB" id="6258424at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705636" description="EB domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35834" checksum="8F1AA92558FD386F" modified="2014-10-01" version="1">MTANERKQSVLSENYHIQLFLLTSLLSLTLADQFHVVSPGPCLHEGDSFCTRRVANSMCSREKNECFCKPGYVAIQEIFGLTCKTRRCDPRVMIYLNPNWTVLKKYTHLRISLVFTRDSTESLAYDIPRLNVLHTCRLLARYSRYCSIFSLSKLLARLVKTLRQPMSAFALLETHQVGTVPEFPLNLCSLILLSNLKCQVDNDCVHVTNSVCHPGAGYCACPSGTIYVPQQHSCCEFTGPFFQRLTWNPAESLVYDVFRQLNVVHQAASCFSRYDIRDIAIHIYFLETTHKVTDNTSTGFALLRAPSGSAVPECLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9I2</accession>
    <name>A0A075A9I2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">tRNA nucleotidyltransferase/poly(A) polymerase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172111.1">
        <property type="nucleotide sequence ID" value="XM_009173847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9I2"/>
    <dbReference type="STRING" id="6198.A0A075A9I2"/>
    <dbReference type="GeneID" id="20322313"/>
    <dbReference type="KEGG" id="ovi:T265_08134"/>
    <dbReference type="CTD" id="20322313"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="71252" checksum="9100E14BE9B39D84" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9N8</accession>
    <name>A0A075A9N8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172031.1">
        <property type="nucleotide sequence ID" value="XM_009173767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9N8"/>
    <dbReference type="STRING" id="6198.A0A075A9N8"/>
    <dbReference type="GeneID" id="20322251"/>
    <dbReference type="KEGG" id="ovi:T265_08072"/>
    <dbReference type="CTD" id="20322251"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="38512" checksum="3C32622BD12088AC" modified="2014-10-01" version="1">MPINSKDGMATIAWSRQGVNMSACEKKETAGREINTFKGTQRLSSSVALQSLQARLLTMEDELAHWKRKYSCLEDSFNSQATVITEFRSSIHNQSDANAASSMQPLQTCLDELTSPYRSNSAPTSSTTDTSVVDQMAADMFADQGQLTCKPFVAIRGDIIGERPSVCLPYRSPVSLRCKPVTRHGDQTNSYPNWPLTSPSSMNNGRERSPSPTDEAFDNVPEKQMIRPSKDKWKISQRRNPSHPESTRWSIRAKPVRQKDPFRAFYPGSSRSYYIWSLWKMYGIAWDDSYRQGPERLEKKHVTLVVELCGSPSEVDHLDGFQMRQAFPLCVQISFNDYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC03</accession>
    <name>A0A075AC03_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171049.1">
        <property type="nucleotide sequence ID" value="XM_009172785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC03"/>
    <dbReference type="GeneID" id="20321477"/>
    <dbReference type="KEGG" id="ovi:T265_07298"/>
    <dbReference type="CTD" id="20321477"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="17872" checksum="9FEF9BB178B1A5C7" modified="2014-10-01" version="1">MDSLSYRSGNINRSALAPFRCLAAVPPEGSTRAGILPGCPSLDRGSRKAEVGFEPRTFRSVNSHSNQLDHLDPLSVSGQYELLTGAFASSNLAATKRKPTMYLAESRGRQPPIENRSAVTSLRCLAAIPPEESWDTARLPKPRQGTSRGRGRVRTTDLPISNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACI2</accession>
    <name>A0A075ACI2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596776">
        <property type="protein sequence ID" value="KER25454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170780.1">
        <property type="nucleotide sequence ID" value="XM_009172516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACI2"/>
    <dbReference type="STRING" id="6198.A0A075ACI2"/>
    <dbReference type="GeneID" id="20321257"/>
    <dbReference type="KEGG" id="ovi:T265_07078"/>
    <dbReference type="CTD" id="20321257"/>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="37031" checksum="ADCE04CE318E5457" modified="2014-10-01" version="1">MLGKHLNFSLSRDKDTDKPIALVHTTASGSDLCQIVCEDITQFYVTLANEPSLAYFRIQEHIRKVTPSLSNERSKIVQVNSELQGCCFDVDYSIRDPHGKLARWALRLQEYEFTIQHLPGKENHLADWLPKPKPEDEVSRIMVAANSLVVKLDPGSAVNSASRATPHLNRLNELLKSSLFTKLQLDYAKKYSTGFEVGVDLVSALASQQQPTMSTTSRKKIPAGSQLPSSSYSFGRNTSPTVEPVNSSPSTTLAGSSQLTGALLTTAIRQNPASINKRAEVTRSADFSGLNGSNLSTSLRNGKARSVVLNPSYSFSYGVSPDQSAETGVEAVELHDSTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF17</accession>
    <name>A0A075AF17_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169012.1">
        <property type="nucleotide sequence ID" value="XM_009170748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF17"/>
    <dbReference type="STRING" id="6198.A0A075AF17"/>
    <dbReference type="GeneID" id="20327999"/>
    <dbReference type="KEGG" id="ovi:T265_13832"/>
    <dbReference type="CTD" id="20327999"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF3">
        <property type="entry name" value="NA(+)_H(+) EXCHANGE REGULATORY COFACTOR-LIKE PROTEIN NRFL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="530" mass="58253" checksum="8879554DC917E7E6" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFC9</accession>
    <name>A0A075AFC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168686.1">
        <property type="nucleotide sequence ID" value="XM_009170422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFC9"/>
    <dbReference type="STRING" id="6198.A0A075AFC9"/>
    <dbReference type="GeneID" id="20327932"/>
    <dbReference type="KEGG" id="ovi:T265_13765"/>
    <dbReference type="CTD" id="20327932"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28032" checksum="B885F19501B90915" modified="2014-10-01" version="1" fragment="single">SSSDGAYEPPCVLRLVDSDFHDRLVNAFDRGLTTFVCLDDISQPTEAVKKQLLQLLVPDRLDPLSTQRIRMVLFTSCPQTEANEETERDIILKQYFVLRAIRSPNVERWSMPDGLEISTTTRDLLRKSELSTHAGCVSENGHLDSSSQKNLSQLAFGFDEQSDQSIDSSKLCSSFESSGFLLALLRRKHATCSDVKIQISPACAGRVMGTRSPRISDVRSSNLGTTKATRYRLVHYRLVQFFPPRPFGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFY4</accession>
    <name>A0A075AFY4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168072.1">
        <property type="nucleotide sequence ID" value="XM_009169808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFY4"/>
    <dbReference type="GeneID" id="20319122"/>
    <dbReference type="KEGG" id="ovi:T265_04940"/>
    <dbReference type="CTD" id="20319122"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8216" checksum="9D576D1CBC4A597D" modified="2014-10-01" version="1">MNMLSECHSPPISATSDHLMLQTTHRPPQHAMNNSPWRIPMFAAQPTRILQTLEERTAAPENRCNCEIYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHW4</accession>
    <name>A0A075AHW4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165716.1">
        <property type="nucleotide sequence ID" value="XM_009167452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHW4"/>
    <dbReference type="GeneID" id="20317250"/>
    <dbReference type="KEGG" id="ovi:T265_03063"/>
    <dbReference type="CTD" id="20317250"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11569" checksum="42D196730E3DB7E3" modified="2014-10-01" version="1">MQKEGRLKATRARFKQNRPMNLKLQVVFVQAERLRVVDLLHTLLQRPVPNLRRPRPGQTPLQKRSRFHRLLDHPKHHHCHCSQRIGHFHLVAARTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN8</accession>
    <name>A0A075AIN8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo/beta-catenin-like repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164283.1">
        <property type="nucleotide sequence ID" value="XM_009166019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN8"/>
    <dbReference type="STRING" id="6198.A0A075AIN8"/>
    <dbReference type="GeneID" id="20316081"/>
    <dbReference type="KEGG" id="ovi:T265_01893"/>
    <dbReference type="CTD" id="20316081"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16711" checksum="476100353E12EA76" modified="2014-10-01" version="1">MAILNLSLKSNTDGGKDIAAQALARLSITSYPRVAFPGQRSLELVQPLLRLLSIDRDALQNVEGLFALTNLASLDDLHRHRIMAEHGVPQIDQCLFHEHPMLRRAATECVANLAQYHAFVVVCGGTLPLEEEDLGAKLYLSSSTERVKLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIT9</accession>
    <name>A0A075AIT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163978.1">
        <property type="nucleotide sequence ID" value="XM_009165714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIT9"/>
    <dbReference type="GeneID" id="20315836"/>
    <dbReference type="KEGG" id="ovi:T265_01648"/>
    <dbReference type="CTD" id="20315836"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="10724" checksum="0F15D5AD8F452B4D" modified="2014-10-01" version="1">MFRFFGIKSQVIAAATTTSTVRACCLKASVANLPLLLHRARTSAAVLETDNLNMEKCSSSSFTEPVFGFLYAVHTSDYCSQAATVGDICQAESPEPVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIX5</accession>
    <name>A0A075AIX5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163939.1">
        <property type="nucleotide sequence ID" value="XM_009165675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIX5"/>
    <dbReference type="STRING" id="6198.A0A075AIX5"/>
    <dbReference type="GeneID" id="20315804"/>
    <dbReference type="KEGG" id="ovi:T265_01616"/>
    <dbReference type="CTD" id="20315804"/>
    <dbReference type="OrthoDB" id="6277693at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30817" checksum="68C34E0D19CD4C08" modified="2014-10-01" version="1">MHTNLVFIPVSTHSLVHVVLTTNDRRTGNIWMLLSTFVPRGLFVALFRYVLYIGMRGCYRSALDYCKILLSLDVEDDPLAVLLMVDHYALLSGQYEWLISLYEWLNPSRNLYLLPNFALSVALSAKFLRDSRIQPSGIRDADLLIQDALILFPGFVTRLLKHASIGNVTNLDRSILFGGEVQREPESLGRLLDLYVARTRHLWTSPDVQTWLESNVETVLILVEPEKCPELSTQPHRPTDSRLMEYAKRYTSESPHICGGQIAKPVFWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ09</accession>
    <name>A0A075AJ09_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_12794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163758.1">
        <property type="nucleotide sequence ID" value="XM_009165494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ09"/>
    <dbReference type="STRING" id="6198.A0A075AJ09"/>
    <dbReference type="GeneID" id="20326962"/>
    <dbReference type="KEGG" id="ovi:T265_12794"/>
    <dbReference type="CTD" id="20326962"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="267" mass="30363" checksum="0A3B87DCC97550AD" modified="2014-10-01" version="1" fragment="single">YAICLGPESAISQTERKASDFLLTCKPTDLYGRLTAATLLMVTAILTFVWAIFSWPKRECANNLRVMLPTLREPTNQNASFPEPIRPLRVSRVLRSGSFNECPRFFRAISVGGRREKVCFLNQWVKLLGRISFEKDTQVPNAAIFTLNREDHTVGNMLTCQLLKDPRVLFAGYKAPHPLEHKIVIRVQTLPPTTPLDVFISALKDLVSEVSNIEEQFRVSFPSTFQPLSSTFRWQPNEDLVAIPPVHNCLFCIRNKELHAMFCSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJB0</accession>
    <name>A0A075AJB0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163147.1">
        <property type="nucleotide sequence ID" value="XM_009164883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJB0"/>
    <dbReference type="GeneID" id="20315156"/>
    <dbReference type="KEGG" id="ovi:T265_00968"/>
    <dbReference type="CTD" id="20315156"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12733" checksum="22FB8B4CD9384E02" modified="2014-10-01" version="1">MKIFYRLFVIGHGLFIGIPPVWLTKYVGNSIRKVSTEQLQTIGHGSKPLICILFKKRNIHLLLERVFLNFPGYLYTVTKLQANAMEQLHKFPNTGDLIINAKNNIHVKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJC4</accession>
    <name>A0A075AJC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163001.1">
        <property type="nucleotide sequence ID" value="XM_009164737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJC4"/>
    <dbReference type="STRING" id="6198.A0A075AJC4"/>
    <dbReference type="GeneID" id="20315030"/>
    <dbReference type="KEGG" id="ovi:T265_00842"/>
    <dbReference type="CTD" id="20315030"/>
    <dbReference type="OrthoDB" id="6287924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704645" evidence="2">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="514" mass="62705" checksum="D09F1C68F4E97DFE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJV6</accession>
    <name>A0A075AJV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162204.1">
        <property type="nucleotide sequence ID" value="XM_009163940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJV6"/>
    <dbReference type="STRING" id="6198.A0A075AJV6"/>
    <dbReference type="GeneID" id="20314420"/>
    <dbReference type="KEGG" id="ovi:T265_00232"/>
    <dbReference type="CTD" id="20314420"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000005">
        <property type="entry name" value="Transcription enhancer factor-like protein egl-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="185"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="185"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1008" mass="110181" checksum="28C4D122F564A672" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTH1</accession>
    <name>A0A074YTH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL611819">
        <property type="protein sequence ID" value="KER18091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178162.1">
        <property type="nucleotide sequence ID" value="XM_009179898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTH1"/>
    <dbReference type="STRING" id="6198.A0A074YTH1"/>
    <dbReference type="GeneID" id="20330462"/>
    <dbReference type="KEGG" id="ovi:T265_16297"/>
    <dbReference type="CTD" id="20330462"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13404" checksum="AE09755D25223644" modified="2014-10-01" version="1" fragment="single">MYEKRYYVSVAYAGNHIYALGGHNGENQGRLDTAERYTLDENLWQTIASMNRVRSDAAAAELGGRVYVAGGFEGRRYHDSAEYYEPDTNQWTLISRMHSPRGGISLAQQGGYLYAIGGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVI7</accession>
    <name>A0A074YVI7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598854">
        <property type="protein sequence ID" value="KER18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177590.1">
        <property type="nucleotide sequence ID" value="XM_009179326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVI7"/>
    <dbReference type="STRING" id="6198.A0A074YVI7"/>
    <dbReference type="GeneID" id="20330071"/>
    <dbReference type="KEGG" id="ovi:T265_15906"/>
    <dbReference type="CTD" id="20330071"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15636" checksum="C471F607229B32ED" modified="2014-10-01" version="1" fragment="single">MAFFRDNLLKHHREVLMTQLVPMQRSIGMFLIDTSTMRSLLLPSPNRCLELFHRLLPVDARAEVDRLVQETQEADYTLSLTPSTTVDFVKHLEFLVHMQTRIEPIEKEADVVKEIYDMIESFSVPVPPEDYAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW02</accession>
    <name>A0A074YW02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597686">
        <property type="protein sequence ID" value="KER18858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177394.1">
        <property type="nucleotide sequence ID" value="XM_009179130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW02"/>
    <dbReference type="GeneID" id="20326293"/>
    <dbReference type="KEGG" id="ovi:T265_12125"/>
    <dbReference type="CTD" id="20326293"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703769" description="RRM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13746" checksum="434BF64B23B686A6" modified="2014-10-01" version="1">MATRLMLRWFLHPLTPFLKSAATIDVLQSSGTVFVQNGPQQGHQTVHQCFTTFGKCEVQTTQAKAAVNMRARGLQLHLSNKTKFTQIDPPTFVNYVTKGSLLVQNHWCGNQDVKAASKEAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYB9</accession>
    <name>A0A074YYB9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_11526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176468.1">
        <property type="nucleotide sequence ID" value="XM_009178204.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YYB9"/>
    <dbReference type="GeneID" id="20325694"/>
    <dbReference type="KEGG" id="ovi:T265_11526"/>
    <dbReference type="CTD" id="20325694"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="763"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="843"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1684"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1524"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1691"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1713"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1723" mass="189916" checksum="B29C331409E2812E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYV0</accession>
    <name>A0A074YYV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597128">
        <property type="protein sequence ID" value="KER19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176403.1">
        <property type="nucleotide sequence ID" value="XM_009178139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYV0"/>
    <dbReference type="STRING" id="6198.A0A074YYV0"/>
    <dbReference type="GeneID" id="20329611"/>
    <dbReference type="KEGG" id="ovi:T265_15446"/>
    <dbReference type="CTD" id="20329611"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32785" checksum="C716F472E322369E" modified="2014-10-01" version="1" fragment="single">FRVLCATCSQEVSTLVSVRSYDFHSPEHFTLSHGKPFLCPNPVHMFSTFKLTGLKNERHDKVLELFKAIKTDKSTRVVVLSAQGEIFSAGMDLTEIPSIFAEAHSNDAARFALALRRVAEDLQETFNWLEKCNKPVIAAIHGACVGGAVDMVCAADIRYASEDAWFQVKELELGIAADVGALQRLPLLLGSDSLARELIYTARRFDASEALACGFVSRVFKTPEETLREAINTAIQIGNHSPIAVQTTKRSLLFSRDHGVMEGLNQLADLNQVMLQSADVVKAIQAAAKKQKAEFDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZZ1</accession>
    <name>A0A074YZZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598002">
        <property type="protein sequence ID" value="KER18782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177472.1">
        <property type="nucleotide sequence ID" value="XM_009179208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZZ1"/>
    <dbReference type="GeneID" id="20326326"/>
    <dbReference type="KEGG" id="ovi:T265_12158"/>
    <dbReference type="CTD" id="20326326"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7297" checksum="422D75C63D277DBE" modified="2014-10-01" version="1">MKTSESCTEPKGVKELAILEHILNGHIKTVHTDEHTEYETQKHTCELRGRRFVYRKDKDTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2C2</accession>
    <name>A0A074Z2C2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175065.1">
        <property type="nucleotide sequence ID" value="XM_009176801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2C2"/>
    <dbReference type="GeneID" id="20324599"/>
    <dbReference type="KEGG" id="ovi:T265_10431"/>
    <dbReference type="CTD" id="20324599"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="20311" checksum="F7DEF636501F9DE4" modified="2014-10-01" version="1">MPKKRSIRNTLLIHLLKNLTAHDRRTSGRLSFRASLNVTFYLNPNCTKLAKCTYSPAILVFTEDPLRTQLKFSFTICMQWPIKSGSAVTPFPCLAATPPEAGTRAKIVPGCPSLDRRSRGVGFAPRAFLTLVVAKASRQVASGSKSCRMIIILLACDGWTTDMVTGRTLTSTTEEFGSSAKTAVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2F6</accession>
    <name>A0A074Z2F6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596982">
        <property type="protein sequence ID" value="KER21231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175019.1">
        <property type="nucleotide sequence ID" value="XM_009176755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2F6"/>
    <dbReference type="GeneID" id="20324559"/>
    <dbReference type="KEGG" id="ovi:T265_10391"/>
    <dbReference type="CTD" id="20324559"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9490" checksum="A8C3F5676F7C1269" modified="2014-10-01" version="1">MSAETPIGAQARSGDKKRWTFDYHLGGNSSLRRFEKSNSDHEGAPDRAGNKNKSRNHQLQHSKPVCESDGDAIKWLHAHEVSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3J5</accession>
    <name>A0A074Z3J5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_11285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597094">
        <property type="protein sequence ID" value="KER20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176164.1">
        <property type="nucleotide sequence ID" value="XM_009177900.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z3J5"/>
    <dbReference type="GeneID" id="20325453"/>
    <dbReference type="KEGG" id="ovi:T265_11285"/>
    <dbReference type="CTD" id="20325453"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1568" mass="173868" checksum="5265C14A13B8870D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4T1</accession>
    <name>A0A074Z4T1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174173.1">
        <property type="nucleotide sequence ID" value="XM_009175909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4T1"/>
    <dbReference type="STRING" id="6198.A0A074Z4T1"/>
    <dbReference type="GeneID" id="20323912"/>
    <dbReference type="KEGG" id="ovi:T265_09744"/>
    <dbReference type="CTD" id="20323912"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22381" checksum="79C93E00530ED89C" modified="2014-10-01" version="1">MGISGDDFALLASDTRLCAEDRYFIYSRNSPHLYKMGNGKVLATTGFHGDVLTLTKLLENRVKTYRYDHGKEISTNAFAALLSVTLYTRRFFPFYVSSILGGLDEEGRGALYRYDPVGSFERVKCAAAGSSGVILQPFLDHRVEGKNLSSGLPPLEKAEAIKLAKDIFISAAERDINCGDAVLIQVITLDGIEEFQFPLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z732</accession>
    <name>A0A074Z732_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596874">
        <property type="protein sequence ID" value="KER22903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173360.1">
        <property type="nucleotide sequence ID" value="XM_009175096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z732"/>
    <dbReference type="GeneID" id="20323287"/>
    <dbReference type="KEGG" id="ovi:T265_09108"/>
    <dbReference type="CTD" id="20323287"/>
    <dbReference type="OrthoDB" id="6235976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="772" mass="86981" checksum="B444DA70A12D3055" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z752</accession>
    <name>A0A074Z752_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596869">
        <property type="protein sequence ID" value="KER23016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173249.1">
        <property type="nucleotide sequence ID" value="XM_009174985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z752"/>
    <dbReference type="GeneID" id="20323203"/>
    <dbReference type="KEGG" id="ovi:T265_09024"/>
    <dbReference type="CTD" id="20323203"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7562" checksum="C78D0F9BB6A7FAB2" modified="2014-10-01" version="1">MERFLDNYGSPTSTRFQSTLRQIQTTSASGGKQPRAVAEHTKYKAKDIDKNSCGFGFPSEYRRDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z806</accession>
    <name>A0A074Z806_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL597230">
        <property type="protein sequence ID" value="KER19375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176878.1">
        <property type="nucleotide sequence ID" value="XM_009178614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z806"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325998"/>
    <dbReference type="KEGG" id="ovi:T265_11830"/>
    <dbReference type="CTD" id="20325998"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Legumain prodomain" evidence="11">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="457" mass="52548" checksum="BF7C42A902F4E982" modified="2014-10-01" version="1">MKLQVNLNVMRRCSLLFGFLFCINHLSWLDAVGVQNWSSTFNNIPWKNWVVLVAGTNAWENYRHQADVFHAYQIVRKNKVPAENIITFAYDDIANNPKNPFKGKVFHDYLHEDVYQGVEIDYRGKDVTRDNFAKVLKGDQKLAANKKKVLESGPDDNVFIFFSGHAGCRGVERAPRPHAFEKKVQQIGALDAVELNGLLAHMHSKKKYNKLVLYVEACQSGSLFRNILPKNVGIYVTTSANEDGQSWSVFCSDKYIDVCLASEYAYAWIGDSEYHDLKTHTLDQQYEEVKKRTAYSHVMRYGEMAMKSLPVGKFQGHYDLPMYRNDSTIQPNAVDRKPSLQAHLFSKSRRLMEAATHEQHETARRKLHRASQLGHIVKETIRDIVRDVKTQPKPTLKDMSKTDELMCFKAVFDQFRTHCFTIQQVPEVAQHTRHLMELCKAGYKADILIESVHNVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z864</accession>
    <name>A0A074Z864_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_08783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172947.1">
        <property type="nucleotide sequence ID" value="XM_009174683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z864"/>
    <dbReference type="STRING" id="6198.A0A074Z864"/>
    <dbReference type="GeneID" id="20322962"/>
    <dbReference type="KEGG" id="ovi:T265_08783"/>
    <dbReference type="CTD" id="20322962"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000046">
        <property type="entry name" value="Glucosidase alpha, neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="140"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="481"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="816"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER23298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123029" checksum="CA8A860F1144152E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z876</accession>
    <name>A0A074Z876_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596943">
        <property type="protein sequence ID" value="KER21757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174496.1">
        <property type="nucleotide sequence ID" value="XM_009176232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z876"/>
    <dbReference type="GeneID" id="20324163"/>
    <dbReference type="KEGG" id="ovi:T265_09995"/>
    <dbReference type="CTD" id="20324163"/>
    <dbReference type="OrthoDB" id="6264219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="476" mass="52736" checksum="621F2BF8FB66155D" modified="2014-10-01" version="1">MQLGVHDVYTISYCKGGSCRNMCAGVVLIKALTGISTHLKHRIPTPSSAVPSYVGQPEAERRANYATIQILCHQRRKDAESAMSDGSWKDLHKDDWKNVREHLYRKKTASLKRRQLEVLIRSETVRDLYHDVVESIIDLYKDSGTGLHPWQHFRAAADKLAELHKFMKLTVARVYALGTAEGAATYSYDFFEKLRDVQAHSNSPTPCRLDFEALRLFSSVQIAEQVAMHFPTLTPEGQETVFVRPLPIEQPGMGYSASVARASPSIDPRVAEVHKPPHHDQSLSELGHVALDVDGFDTTDVNSGSHQFIPFDYLRGYLSQPDDPLPKRMRRNKRTARRRQRRYSNIKPNSSSNLLLTDSQTPACAHIPSELHVRQPNPSSSGRVADQCEKGQVSQSDALLPVLSNFHSSRGEAESYLSEDSSGASLCSCACGDDSFTDTSSSANEEDEADFHRGRSTASRPTVGSTSGPPPFSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8D1</accession>
    <name>A0A074Z8D1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597194">
        <property type="protein sequence ID" value="KER19490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176759.1">
        <property type="nucleotide sequence ID" value="XM_009178495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8D1"/>
    <dbReference type="GeneID" id="20325917"/>
    <dbReference type="KEGG" id="ovi:T265_11749"/>
    <dbReference type="CTD" id="20325917"/>
    <dbReference type="OrthoDB" id="10070415at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="232" mass="26149" checksum="A326870F34780C64" modified="2014-10-01" version="1">MQSLNTPLATQGGAAEVDVSGQVVNALTRRAMVRTQHRHLDFSHLDFVIIIIESMTSVFNTDASLPYNHDLFESLIHPCLPCHYKEARMLGYCQVVQAKTGEVLEQRHMYRRPTLLIYLDFKCVFDSVERSVLLTAPAQQGMPIMHGGLSKSFLIKSGMRQGCPLSPLLFTFVVDEIMARILVIKTPVSKMFLVTTFSIWSTQTTAFSSLKSEVQHKHHHTIVRHAPINSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8I8</accession>
    <name>A0A074Z8I8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596846">
        <property type="protein sequence ID" value="KER23531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172729.1">
        <property type="nucleotide sequence ID" value="XM_009174465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8I8"/>
    <dbReference type="STRING" id="6198.A0A074Z8I8"/>
    <dbReference type="GeneID" id="20322789"/>
    <dbReference type="KEGG" id="ovi:T265_08610"/>
    <dbReference type="CTD" id="20322789"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="19343" checksum="A91A6970CD6598FA" modified="2014-10-01" version="1">MTYALYVDLEASHTSSVMAFRHGWAVFVHISRDADAMTHGIYGVGVALSPKAEGTLLDWITANNRLCALQVDAKSSNKPLLAGTRLTHNYVRPNLSSALYISQSPVKLHHCQPQRLLSQAANDTPVARKYARGTSHATIIDSLFDSLRQADCDTVDANDLLDLGGVFQFPSPLCSNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8J2</accession>
    <name>A0A074Z8J2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597179">
        <property type="protein sequence ID" value="KER19550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176696.1">
        <property type="nucleotide sequence ID" value="XM_009178432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8J2"/>
    <dbReference type="GeneID" id="20325876"/>
    <dbReference type="KEGG" id="ovi:T265_11708"/>
    <dbReference type="CTD" id="20325876"/>
    <dbReference type="OrthoDB" id="6225793at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="246" mass="28871" checksum="C8D48E9C59E3631C" modified="2014-10-01" version="1">MNIKSIVAEVNDVIPIARCQTTHCRVHKQLPLTSPVYVYQQVRALAPQSRTLLAFRLSPPGYHPSEFFKCGLSVPQADAMGKPDERLRWNQNLNRVKHPLDRYRPWANDRSGLRLLDWEASDVDCLPPKLGNFDYLPVCLVDPSPLTQHFNALDNLNAQHPRYLLEHYVYRDPDEYHRAKEEGKYACYLDCDAREFRELKPMNQREIMRLRFATNNYRTFDDWKEDPNDELLGQFDRPKTQKEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z904</accession>
    <name>A0A074Z904_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597152">
        <property type="protein sequence ID" value="KER19705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176552.1">
        <property type="nucleotide sequence ID" value="XM_009178288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z904"/>
    <dbReference type="GeneID" id="20325764"/>
    <dbReference type="KEGG" id="ovi:T265_11596"/>
    <dbReference type="CTD" id="20325764"/>
    <dbReference type="OrthoDB" id="6270795at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704007" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28886" checksum="BB96164F3D0DE1A0" modified="2014-10-01" version="1">MMALKLCCLIFAVNSVLSNEIDVQVRILAPNGPLMDVSICETLKVRAPQFWEGGLFTQCSFDYLYRHDKDDLQVEIMYEVKTNISKFPEEFQADLPYDFQMWFLNRLLNGGETRCLTATGEAQDSDAYEVEGYIADYTAREKFILVAPFAEDFCLKFINKKFNQDQLEVSNCTLLEKSTIPVDGHILGKYALSTTERQLNFVPFQYHDIYIFFLKELNGDEGECNYNGYWANVKFVENKNTMPDDDDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9A7</accession>
    <name>A0A074Z9A7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176429.1">
        <property type="nucleotide sequence ID" value="XM_009178165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9A7"/>
    <dbReference type="GeneID" id="20325664"/>
    <dbReference type="KEGG" id="ovi:T265_11496"/>
    <dbReference type="CTD" id="20325664"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="344" mass="38061" checksum="E452EF3657CC6663" modified="2014-10-01" version="1">MKLGTLKLVTQSVTCERINCHCGGGKLVNLAIVAHAHASEFLLKDGFLNEVVKKSSSCSTLSVPNCHTTRRLHEGWDNARMPKPRQGKSRGRGRIRTTDLPISFVLHLTKKAKNRVENSVSFSATEFVVIVSNGESDQTDLELKSEQLSDGHRNQALVKILVVKIEPPTASEVYDRICSLKRGGAPSPQSACLICLQAFVKRNLSQTTGEIATTTSYAKTTHNYSIPGFPGAFDSVNRFALFDTLTHQRMSRKFVNIISFLVFSGFRTQSCVPLSPFPFNFEIGARWTKWLEREFTDRKVRGSNPTSATRLPLSRLGRPGSIPALVQPSCGMAARHRMVATAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAZ9</accession>
    <name>A0A074ZAZ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596883">
        <property type="protein sequence ID" value="KER22712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173539.1">
        <property type="nucleotide sequence ID" value="XM_009175275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAZ9"/>
    <dbReference type="STRING" id="6198.A0A074ZAZ9"/>
    <dbReference type="GeneID" id="20328960"/>
    <dbReference type="KEGG" id="ovi:T265_14794"/>
    <dbReference type="CTD" id="20328960"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="656" mass="74849" checksum="FFD1CFC1D6087080" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC60</accession>
    <name>A0A074ZC60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171541.1">
        <property type="nucleotide sequence ID" value="XM_009173277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC60"/>
    <dbReference type="GeneID" id="20328521"/>
    <dbReference type="KEGG" id="ovi:T265_14355"/>
    <dbReference type="CTD" id="20328521"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="138" mass="15171" checksum="3EBEE5F4240DB115" modified="2014-10-01" version="1">MLRIPVREWELEESGLHILVWKQASKDPQPKKGQTVWNALQGQALAQSRIAHQAQSVRHTVSGVKLNGKNVPSTPCATHKSVISTQGAHNGKQTQVTDCDLRKSQSNNSLSGFREADPSIGDDHRLLNQKVDITTDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCG6</accession>
    <name>A0A074ZCG6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597011">
        <property type="protein sequence ID" value="KER20895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175351.1">
        <property type="nucleotide sequence ID" value="XM_009177087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCG6"/>
    <dbReference type="GeneID" id="20324813"/>
    <dbReference type="KEGG" id="ovi:T265_10645"/>
    <dbReference type="CTD" id="20324813"/>
    <dbReference type="OrthoDB" id="6280720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="29627" checksum="3BEB3C9C29AAD1FF" modified="2014-10-01" version="1">MDLLDLSAKAVIELRLSKVTSFCLFFMLLLLRRRLKREQAIVKYLRNIPATPNPISAAILSYEYKLNDSCRNFRIVLYQFALLCGLRLFRGSAQLMQRFVTQRKVPKKEIKTAWFTLWNLATFVETILTTLPYFIWYAIVPEMSRNSCRRKHTNTGTKKTVTGTLSELDNYFAQALHNLGDTVVEERRFPLIMRHLKMCKMRLLNKYTEAKTKPYGEQLESVDPIPCVNAGGLSVSHPEDNLTRGVSELLTRRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCN7</accession>
    <name>A0A074ZCN7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171323.1">
        <property type="nucleotide sequence ID" value="XM_009173059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCN7"/>
    <dbReference type="STRING" id="6198.A0A074ZCN7"/>
    <dbReference type="GeneID" id="20328474"/>
    <dbReference type="KEGG" id="ovi:T265_14308"/>
    <dbReference type="CTD" id="20328474"/>
    <dbReference type="OrthoDB" id="64868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="3">
        <location>
            <begin position="511"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125357" checksum="ADD3DC56BEC24509" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCQ2</accession>
    <name>A0A074ZCQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597005">
        <property type="protein sequence ID" value="KER20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175267.1">
        <property type="nucleotide sequence ID" value="XM_009177003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCQ2"/>
    <dbReference type="GeneID" id="20324754"/>
    <dbReference type="KEGG" id="ovi:T265_10586"/>
    <dbReference type="CTD" id="20324754"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7607" checksum="9BC193C9D8039ED7" modified="2014-10-01" version="1">MTNICEVTSSLYYRVTGSRYALIDRMDNMPAILLGTFQFAPDKKQTDVIQEMEHFITSYFTDECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDP6</accession>
    <name>A0A074ZDP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174923.1">
        <property type="nucleotide sequence ID" value="XM_009176659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDP6"/>
    <dbReference type="STRING" id="6198.A0A074ZDP6"/>
    <dbReference type="GeneID" id="20324491"/>
    <dbReference type="KEGG" id="ovi:T265_10323"/>
    <dbReference type="CTD" id="20324491"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000234">
        <property type="entry name" value="Polyadenylate-binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="102"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="258" mass="29239" checksum="701ED6656B3B8FE3" modified="2014-10-01" version="1">MAVATQTAQSLPQTSLYVGDLHPLATEALLYSKFSEIGTVLSARICRDLATRNSLGYGYVNFEEPKDAERALENLNYESFMGRPIRIMWSQRDPSLRKSGKGNIFIKNLDKTIDQKQLYDTFSFIGKILSCKIAMDEHGNSKGYGFVHFEKEECAERAIEKINGMMINDRVVYVGKFIPSSDRKSASGKLRFNNIYVKNFPPDTTDEKLRDMFSEFGEIKSCCVEKNPEGKSKGFGFVCFHDPDHAEQAVRVIRTLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDQ7</accession>
    <name>A0A074ZDQ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170907.1">
        <property type="nucleotide sequence ID" value="XM_009172643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDQ7"/>
    <dbReference type="STRING" id="6198.A0A074ZDQ7"/>
    <dbReference type="GeneID" id="20321366"/>
    <dbReference type="KEGG" id="ovi:T265_07187"/>
    <dbReference type="CTD" id="20321366"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="67836" checksum="D7E2B7D5082ADD18" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE83</accession>
    <name>A0A074ZE83_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170665.1">
        <property type="nucleotide sequence ID" value="XM_009172401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE83"/>
    <dbReference type="GeneID" id="20321163"/>
    <dbReference type="KEGG" id="ovi:T265_06984"/>
    <dbReference type="CTD" id="20321163"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="42475" checksum="F30E3968714716F9" modified="2014-10-01" version="1">MKLLTRLLKTLRQFTTDFALLGSHQVAHSTWLIHEIKGNDCIKVSVGQRVRELHTTMGKRRRKINRKSRNADDYRAALKNSALKEHTLNTEHKIDLENIDARTMVHNGGHRTGKRVENCFDPVELTRYQELSSAEFRLTSSTFPPPTSPPPNEIYRWHPRKLVRSDGSEVNSELTDRKVHGSNPTTASRPLWSRLGQPGMMVTIALGTATVEEYMVIVAALFVKNLSSRLYCSTREIMNHIKRFGRVSTQYEGILYSKDIAPENVEVLRWSTSWRVIAEAAEIAKHPSVNRIEGVELASVWRSVLVKLSQNSRGHEDQRKSTSGTLKWKIKQQKAIRTNLRLEKYTLVFKSIWFSQETQLNLSFMMFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEF1</accession>
    <name>A0A074ZEF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170697.1">
        <property type="nucleotide sequence ID" value="XM_009172433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEF1"/>
    <dbReference type="STRING" id="6198.A0A074ZEF1"/>
    <dbReference type="GeneID" id="20321191"/>
    <dbReference type="KEGG" id="ovi:T265_07012"/>
    <dbReference type="CTD" id="20321191"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="478"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="590" mass="66600" checksum="F9D62419CB3A9377" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEQ2</accession>
    <name>A0A074ZEQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Immunoglobulin domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Tan P."/>
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                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
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                <person name="Hu M."/>
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                <person name="Tan P."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PORCUPINE"/>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="73356" checksum="EE3B68873E125A9C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGA4</accession>
    <name>A0A074ZGA4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171575.1">
        <property type="nucleotide sequence ID" value="XM_009173311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGA4"/>
    <dbReference type="GeneID" id="20321894"/>
    <dbReference type="KEGG" id="ovi:T265_07715"/>
    <dbReference type="CTD" id="20321894"/>
    <dbReference type="OrthoDB" id="10024116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32613" checksum="F5D4772F4B0752CC" modified="2014-10-01" version="1">MSPEGSMRAGILTGCPSLDRGSREAEVGFEPRTFRQLNVLHQAASCVSCYDIRNIAIHVYSYCTTHEVAENSSTAHDDRFRPSWGSPAVASFRCLTVTPPEESTRAGILPGCPSLDRGSREVEVRSEQRTFRIPLGESATTALHGYKTKHGLIKDPFTVSTITRLIAKFESTGSVLDFPGIGRKSLSDERAPIVQNAVEQLQSQSTMASSSIAEASQLTGIPRAKVHRIMRRHHHLHPYHFTLLQNITEEDKEHHVTFANWLLDNEEIVPNILWSDEANFSVDDIINKHNCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGJ1</accession>
    <name>A0A074ZGJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171495.1">
        <property type="nucleotide sequence ID" value="XM_009173231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGJ1"/>
    <dbReference type="GeneID" id="20321837"/>
    <dbReference type="KEGG" id="ovi:T265_07658"/>
    <dbReference type="CTD" id="20321837"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19621" checksum="FA26DCD8357BA818" modified="2014-10-01" version="1">MGIVADRDCQGAPRQKKKHMCRVTHPQGHHRLDMSGNFKSDSLCSQPTWLFCAQEYELSHAVTVTMRRVEVSVAIKTRHKRKPHLSVVRIRTWMLNHRRSDAGRWTLIMIGRLDGRYRSLDGWLGRKAKGHAECTEGARLKGHPIYQLASQQSDKLDRTSSLPVIIRGYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH57</accession>
    <name>A0A074ZH57_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169733.1">
        <property type="nucleotide sequence ID" value="XM_009171469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH57"/>
    <dbReference type="GeneID" id="20320441"/>
    <dbReference type="KEGG" id="ovi:T265_06259"/>
    <dbReference type="CTD" id="20320441"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14546" checksum="F5E4BC232F63DC90" modified="2014-10-01" version="1">MHQFTSSRVQCAATYPPPKSSVNETAAATTSVRRYIRTEFALALFRGLTAMQPEGSTRWDIARLPEPRQGKSRGRSQVRTTDLPRVAMPKTIARLPHVIKRKLPTVQRLFATYDLCRPARLAIILMPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHF3</accession>
    <name>A0A074ZHF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169612.1">
        <property type="nucleotide sequence ID" value="XM_009171348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHF3"/>
    <dbReference type="GeneID" id="20320337"/>
    <dbReference type="KEGG" id="ovi:T265_06155"/>
    <dbReference type="CTD" id="20320337"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="23587" checksum="92EBCEDC5B5481F2" modified="2014-10-01" version="1">MLVLEAAVTGCSGRQPRNPAIAGTGTNAISTFHYFESNFSAVTLFWCLAAMPPEWSTRKERLSGCPSLDKSIRDADVEFETLTSRHASQMQPEVIECRTVCEPLAFYSYASAVNLPNPVKKSSSLHSESSNGNGPNVETILQKCESVQMTAPFSMRFTSERCLSLLQDWVESNPNLMLADRPIDVVDAFVYLGTRISTCGNAVAFIAISPKLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIL8</accession>
    <name>A0A074ZIL8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596770">
        <property type="protein sequence ID" value="KER25642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170600.1">
        <property type="nucleotide sequence ID" value="XM_009172336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIL8"/>
    <dbReference type="GeneID" id="20321112"/>
    <dbReference type="KEGG" id="ovi:T265_06933"/>
    <dbReference type="CTD" id="20321112"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10305" checksum="F2F1A296CBBDA217" modified="2014-10-01" version="1">MNFKDEIDPTINSPVSTLKCKTPFTAVAWAPGSYDEDDYWIQTVSCLGSYDEDDYWIQTVDEFQRSHLPGSSDLLHSKYIATVVLQREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ19</accession>
    <name>A0A074ZJ19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER27328.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic spindle midzone assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="63113" checksum="04B2CD176A4ECBEB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ32</accession>
    <name>A0A074ZJ32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168906.1">
        <property type="nucleotide sequence ID" value="XM_009170642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ32"/>
    <dbReference type="GeneID" id="20319772"/>
    <dbReference type="KEGG" id="ovi:T265_05590"/>
    <dbReference type="CTD" id="20319772"/>
    <dbReference type="OrthoDB" id="10390671at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="12363" checksum="76677D7EF90D034F" modified="2014-10-01" version="1">MTKDRKFLFEAETMMYISTEKLSGMIITESTYEVSRSDLLKYTRRKISSGLLHKEHYLLIYPERRLKYPEWKIIRFRLHYVTVMKPGEITFPEQWQVGLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJD9</accession>
    <name>A0A074ZJD9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrator complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170374.1">
        <property type="nucleotide sequence ID" value="XM_009172110.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZJD9"/>
    <dbReference type="GeneID" id="20328285"/>
    <dbReference type="KEGG" id="ovi:T265_14119"/>
    <dbReference type="CTD" id="20328285"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1453"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1480"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1584"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1606"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1633" mass="182506" checksum="EE8AE14584020A4C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK75</accession>
    <name>A0A074ZK75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170120.1">
        <property type="nucleotide sequence ID" value="XM_009171856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK75"/>
    <dbReference type="GeneID" id="20320739"/>
    <dbReference type="KEGG" id="ovi:T265_06560"/>
    <dbReference type="CTD" id="20320739"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12411" checksum="E751969BD57C0B2E" modified="2014-10-01" version="1">MAQWLEREFTNRKVRGSNPISVSRLPLARLGKYPSPRAAYGHGERKLVFETLKMLFRSQEKGLTVELLPQPYGKEKSKCGRGKDLVLAHHNHSEVHTPPDIHSGNLDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK81</accession>
    <name>A0A074ZK81_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_05498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168784.1">
        <property type="nucleotide sequence ID" value="XM_009170520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK81"/>
    <dbReference type="STRING" id="6198.A0A074ZK81"/>
    <dbReference type="GeneID" id="20319680"/>
    <dbReference type="KEGG" id="ovi:T265_05498"/>
    <dbReference type="CTD" id="20319680"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="383" mass="44096" checksum="0FC7445D90AAC84F" modified="2014-10-01" version="1">MWMRTIRAETPTTCVEQVPRFNGTSSAHLEEGHGQLTVRALSNEMGPALACLRTGEHDAPTSEETLCERCLEPFLSAENIVSYRDGLFHQKCFVCVQCFQPLSLAEFYEHEERRYCKYDFQMLFAPFCHKCGEFVMSRVIKVLGRSWHPECLLCDQCGAELVVTGLHKFNGRPLCRACFNELSQVQSTGHLCQTCRTYVSKSEMIRFKGDPHHPHHFKCARCEVELGPDARERGGDLYCLQCFDKLGIPVCAACRRLVEGRIVWALGKPWHVEHFVCHQCEVPFMGGRFYELQGRAYCFPHYQARTGSTCHICCQPVMDILARFTNKAYCPGHFTCFICDRKLNEKSKLYEIDLKPACKECYDKLPTHWKKRLAKLHMLEAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL22</accession>
    <name>A0A074ZL22_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596824">
        <property type="protein sequence ID" value="KER24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172185.1">
        <property type="nucleotide sequence ID" value="XM_009173921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL22"/>
    <dbReference type="GeneID" id="20322371"/>
    <dbReference type="KEGG" id="ovi:T265_08192"/>
    <dbReference type="CTD" id="20322371"/>
    <dbReference type="OrthoDB" id="10395572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13400" checksum="27928EF48934514F" modified="2014-10-01" version="1">MQPEGSTRAGILPGCLSLDRGSREAEVGFEPRPFRSIPRTKGARWTKWLEREFTDRKVRGSNPTSATRLPLSRLRQPGSIPALVPPSCGMAARHRKGATAGRLPPNKTGLIALSALRCSGSVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL97</accession>
    <name>A0A074ZL97_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172154.1">
        <property type="nucleotide sequence ID" value="XM_009173890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL97"/>
    <dbReference type="STRING" id="6198.A0A074ZL97"/>
    <dbReference type="GeneID" id="20328658"/>
    <dbReference type="KEGG" id="ovi:T265_14492"/>
    <dbReference type="CTD" id="20328658"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55924" checksum="CEC81AC87A192273" modified="2014-10-01" version="1" fragment="single">MSSDNQTDTIRLSDLKAPTIGCSCFHLPRIKLHTKRIRQFSDSPSQLSLDIIQNGVSANKQVRCNVPKRDNDDVHETAWSDGCVFGNRAESLSELTEDASQVTALKLTVPDSKSQDNAPKQTKRRLKLCAPCTMENKFNASVQIRKAKKLFSVFCWAVLTTAMLSISLTIWILCGTQSFVLAQLPNDTTSLDCKRFITNRDDIVSGGLNNDVTDDVTSIGDEKFAITANRPITKQRTRTIYIPQHLLGYWSVRRDCQLDCKRFITNRDDIVSGGLNNDVTDDVTSIGDEKFAITANRPITKQRTRTIYIPQHLRPPSFLTQFATSWTLVLYPIYLICNVILRFEKASSNELLMQNYESIVFSSRNHMVILASDQPTIVKVLTRCILLSILWQLFLNCFLRSMEVVSPIDCAAIMAVLPCFHYLFSWIIVHRRFCALRVIAFILASSGVIFNIYSDQYSMWYKCLSSVAVVAFALFNVSCPYLSFQRFVLSSALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLP8</accession>
    <name>A0A074ZLP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13623</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168005.1">
        <property type="nucleotide sequence ID" value="XM_009169741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLP8"/>
    <dbReference type="GeneID" id="20327790"/>
    <dbReference type="KEGG" id="ovi:T265_13623"/>
    <dbReference type="CTD" id="20327790"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07847">
        <property type="entry name" value="STKc_CDKL1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF222">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="54"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="592" mass="66163" checksum="DE36EC771D73979F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM68</accession>
    <name>A0A074ZM68_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167775.1">
        <property type="nucleotide sequence ID" value="XM_009169511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM68"/>
    <dbReference type="GeneID" id="20318889"/>
    <dbReference type="KEGG" id="ovi:T265_04707"/>
    <dbReference type="CTD" id="20318889"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9175" checksum="4448BE6A44CDCD9A" modified="2014-10-01" version="1">MMEKKRQFWRRSTVTSTAGDGCVITWAHGRVDCIRLHTFGMPGFRHSKLGTEDSAHLGMLHTVYPPYLAVKDNVLQQRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM84</accession>
    <name>A0A074ZM84_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167738.1">
        <property type="nucleotide sequence ID" value="XM_009169474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM84"/>
    <dbReference type="GeneID" id="20327722"/>
    <dbReference type="KEGG" id="ovi:T265_13555"/>
    <dbReference type="CTD" id="20327722"/>
    <dbReference type="OrthoDB" id="6308191at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="459" mass="51379" checksum="6191971547B891C5" modified="2014-10-01" version="1" fragment="single">PQAPTNIRLERSKKRGLLATWDDNNECLKRQGPRYGVYVYDETNRLVYEIYVAEKSAFLGGLDVCSPYWVRISTIGIEGVSSASARIKTFDPPLAPSATRVNLRPNGNSATVSWEYRDTCAAESFQVSLYSSDGLTLRTVNTNDREVHLGDLPVNVPLLVDVSGQNAEGTGPRGERVQFILPTIPPSTQTNLVSYQEPRSPIDIAVSVLRGRPEVNVSWTVANSQTNQSFTVRLYNGSSVIQQRTTEYFNTSFQQVDPCSSWTVGVIAHNAHGTAEEWFTEEFRIPAGVEKCALVSPSRIISKSRQKITDSLRMLHKRTQSRKKYPLNCAQMMSPRVVTKRLQANCQARRTDQQPADQQPINYRSKSPEPPVGVTIQLHRRKRMVTVSWMHHCAHTFTVYLYTENTVTNEQTTRDHHMTFGNTPRSMNFRVGVVATNDYGTSVEAISAAFCTSGCCGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPZ2</accession>
    <name>A0A074ZPZ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166729.1">
        <property type="nucleotide sequence ID" value="XM_009168465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPZ2"/>
    <dbReference type="GeneID" id="20318060"/>
    <dbReference type="KEGG" id="ovi:T265_03873"/>
    <dbReference type="CTD" id="20318060"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6647" checksum="BA5D5D74B4079256" modified="2014-10-01" version="1">MGKRILRPESISAVTRRKHEGWDTAGSPKSRQGKSRGRGRVRTTDLPVSKLMLQRLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ04</accession>
    <name>A0A074ZQ04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13355</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Opisthorchiata</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
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</entry>
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                <person name="Nagarajan N."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Tan P."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18432" checksum="7D4EBB026FABA73C" modified="2014-10-01" version="1">MAFYKKPDEDESLNEKDPEGIKRGEYRKMGIYDFVRRDIERYHAHPEEAIVSPELLKSKELKPPPEFVRNVWGSAAGVGSGDFHIYRGIRRREYARLEYIEKTAEEEKLNKEFQERQRMLDETAEAKTAKKRLKRQKKKAKRIAKSGQLKNTDSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR44</accession>
    <name>A0A074ZR44_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170439.1">
        <property type="nucleotide sequence ID" value="XM_009172175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR44"/>
    <dbReference type="STRING" id="6198.A0A074ZR44"/>
    <dbReference type="GeneID" id="20328300"/>
    <dbReference type="KEGG" id="ovi:T265_14134"/>
    <dbReference type="CTD" id="20328300"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32401" checksum="A0690A24CCB9E309" modified="2014-10-01" version="1">MFKVDLPLDREGPQVQNRGFSAEGPLLVIGAGVGRTGTTSLKHAFEIIYGQPCYHGYELIERHPEHCPKWLEIDRLLDNSLGDDDVFDPSLFQQIYKGFRSGTDIPTSCYYKQLMKVYPDVKVVLTTRDSQKWLTSARETIFPRIPDVPTSWIGMLVCEVLVGMGFLRVKSRCSERMFGPQSDRDDDRKLLEAYERWNAQVKQAVPANQLLVFDIRDGWEPLCKFLNVPIPNEPFPCTNDRTIVAMIKRKIDRLTMVLRCTAVGTAVLICCYFTYRRLRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSD7</accession>
    <name>A0A074ZSD7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Malate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_16243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="7"/>
    <dbReference type="EMBL" id="KL607769">
        <property type="protein sequence ID" value="KER18174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178079.1">
        <property type="nucleotide sequence ID" value="XM_009179815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSD7"/>
    <dbReference type="STRING" id="6198.A0A074ZSD7"/>
    <dbReference type="GeneID" id="20330408"/>
    <dbReference type="KEGG" id="ovi:T265_16243"/>
    <dbReference type="CTD" id="20330408"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER18174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12035" checksum="A8BCBE5A07B50D10" modified="2014-10-01" version="1" fragment="single">MTRDDLFTTNASVVAQLAHACALNCPKAMICVVTNPVNSTVPIAAEIMRRHGVFDPQRLFGVTTLDIIRSNTFIAEAKGLDVQKVSCPVIGGHSGITILPVISQCSPTVSFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSG6</accession>
    <name>A0A074ZSG6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169943.1">
        <property type="nucleotide sequence ID" value="XM_009171679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSG6"/>
    <dbReference type="GeneID" id="20320600"/>
    <dbReference type="KEGG" id="ovi:T265_06421"/>
    <dbReference type="CTD" id="20320600"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15230" checksum="F871E0C38ADFCA18" modified="2014-10-01" version="1">MGEGISASLTQSFRGAYTSRHSLRLCEGRGTLSSIAQWIAEVRKPSHHGKVQFLRDGPRTFRSVSWRLNHWDISMVVNHSQHCNPQWRQKAFIQRVGEIFQFRRNSTLQCPVQHVGGGAVKRVHESGPQNDLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSS9</accession>
    <name>A0A074ZSS9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="OrthoDB" id="6256705at2759"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER28892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="12739" checksum="CC24F63DEB1ACE97" modified="2014-10-01" version="1">MMFPAILLLAYLLTGTDAITCLTCADCKLPIAAQGSTAVVSADNCAACSLIITFTGSRTPSTIAAACVADAANCNPAYAATQAGAVVTSCCTTANCNALPGVGRKLLPSYSSLIIPFVALFYSAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSV4</accession>
    <name>A0A074ZSV4_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009167522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSV4"/>
    <dbReference type="GeneID" id="20317304"/>
    <dbReference type="KEGG" id="ovi:T265_03117"/>
    <dbReference type="CTD" id="20317304"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="205" mass="23632" checksum="64EAC838C5EDEBB5" modified="2014-10-01" version="1">MLPSVLIQTNRCSRVHRKLRQEKALVRNDRGHSADNPVKSINELCRKIAARRFQKSSREGCLLICKSILTFTRDSTESLVYDILQLSVLHTGRLMIQIILRKAKKLVLKNRMGEIHKLNLLPSVLIQTNRCSRVHRKLRQEKALVRNDRGHSADNPVKSINELCRKIAARRFQKSSREGQLIVLHQAASCFDCYDSRDIAIHVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSW7</accession>
    <name>A0A074ZSW7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome component Ecm29 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169757.1">
        <property type="nucleotide sequence ID" value="XM_009171493.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSW7"/>
    <dbReference type="GeneID" id="20320455"/>
    <dbReference type="KEGG" id="ovi:T265_06273"/>
    <dbReference type="CTD" id="20320455"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="2">
        <location>
            <begin position="416"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2060"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2430"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2068"/>
            <end position="2095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2795" mass="301289" checksum="4E8B927F375C5D4D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUC8</accession>
    <name>A0A074ZUC8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597898">
        <property type="protein sequence ID" value="KER18804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009179185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUC8"/>
    <dbReference type="GeneID" id="20329983"/>
    <dbReference type="KEGG" id="ovi:T265_15818"/>
    <dbReference type="CTD" id="20329983"/>
    <dbReference type="OrthoDB" id="10002367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="40" mass="4722" checksum="71D587221E51F0D8" modified="2014-10-01" version="1" fragment="single">MARLWRAMKNTEPVLVMTRGLREPRASLTGNLVAFDRYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV34</accession>
    <name>A0A074ZV34_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169025.1">
        <property type="nucleotide sequence ID" value="XM_009170761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV34"/>
    <dbReference type="STRING" id="6198.A0A074ZV34"/>
    <dbReference type="GeneID" id="20319874"/>
    <dbReference type="KEGG" id="ovi:T265_05692"/>
    <dbReference type="CTD" id="20319874"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF259">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="341"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="541" mass="60378" checksum="A549269888B8F840" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV35</accession>
    <name>A0A074ZV35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164885.1">
        <property type="nucleotide sequence ID" value="XM_009166621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV35"/>
    <dbReference type="GeneID" id="20316576"/>
    <dbReference type="KEGG" id="ovi:T265_02388"/>
    <dbReference type="CTD" id="20316576"/>
    <dbReference type="OrthoDB" id="6283036at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="104"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="461" mass="50066" checksum="E186E2150928EFD3" modified="2014-10-01" version="1">MTLVTLSSPCTDNCLFPREPLEDIYLLLHDRTEMSCWQGVNHGVRTSTSKPSWFSSCSCSSSAMTVSSVCCYRNTSRKMTTSTATDVAPGLSPKNGQIPPTDPDSGDDVCHIPQPVFSLFVYLAQQGGHVNDMFRRPGNITQMRQILQEFTSGNPVNWSDYNVYTVANVAKKLLLSIPDGLFGVRGEALLLSTASGSSCSTEVDELLDPVLSSRSVVAESHCSRLFPPGDQKTVTFADDLNPLGSVSSRLPRGSVIQLTQLSEVAERRIAVFLRVLESLPSSHRQFSILVFGLLHQLVMNATSSAASCSLSSLVDLSRSSGTLLPKREDAKDVGLAVAEVPLLVLAEGVVKSVAGALFHTCCSSIHLVEQAAQVLRTLVLFFPAMGDSVTRFFVEAVANRLPPRKTLTTDSGRPVASRSFCVLCPETGKLPSFGDILRHFHFLSHIIGFCQSYTEHKFQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVB2</accession>
    <name>A0A074ZVB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166510.1">
        <property type="nucleotide sequence ID" value="XM_009168246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVB2"/>
    <dbReference type="STRING" id="6198.A0A074ZVB2"/>
    <dbReference type="GeneID" id="20317891"/>
    <dbReference type="KEGG" id="ovi:T265_03704"/>
    <dbReference type="CTD" id="20317891"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55687" checksum="9D1BE52A3B3CEB36" modified="2014-10-01" version="1">MSDSKSQTNAAPEAAANDVYRGPETKGWWRELCCIPLRMDSRLAVVTGANSGIGLSVTGELARRGATVIMACRDISKAQSAKDSLLRMYGAENPESTKTDVVDETISSILSPIQDEQLRLEQLDLSSFESIRNFVERFIKTNEPLDYLINNAAIISRTYEKSVDGQELQLAVNYLGPVLLTELLLPSLKKSPKGRIVNMTDALHYLGNLHKPTLHLSGSSYGPYVAYNQSKLALTMYTVELARRLEGTSVIPVSVYPGPVNTAFQKSSNSTLELRLEQLDLSSFESIRNFVERFIKTNEPLDYLINNAAIISRTYEKSVDGQELQLAVNYLGPVLLTELLLPSLKKSPKGRIVNMTDALHYLGNLHKPTLHLSGSSYGPYVAYNQSKLALTMYTVELARRLEGTSVIPVSVYPGPVNTAFQKSSNSTLEKMYTALTMPQRISPWEAAQQVIHALLRRRLIPGGYYDRYDRGFPDRLALTQLERTWLWDKTKEILQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVS0</accession>
    <name>A0A074ZVS0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165047.1">
        <property type="nucleotide sequence ID" value="XM_009166783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVS0"/>
    <dbReference type="STRING" id="6198.A0A074ZVS0"/>
    <dbReference type="GeneID" id="20316708"/>
    <dbReference type="KEGG" id="ovi:T265_02520"/>
    <dbReference type="CTD" id="20316708"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF2">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="450" mass="49479" checksum="0B00488D3463B778" modified="2014-10-01" version="1">MFHLDTSLILRCSPSTALWIFSRRFSEKLLYGDELIRKPSSRIKPNPVQRASVTVPNPHNSRTAVFTSGRESLKQARIAKQAYAELEGNDPRLCDAIEVARGRRARQSPVSPAMRTVVLEGEQLIMDALASGGHVHSLYFSSRHALQRLVSTERIEDIYYVPRHTLERFSSMKTCPGLLAIFEVPDPASLTTRYLSHGLWRPLPATLVLNGIRDPGNMGSLLRTAASFGLSSVLVSEGSVDIWNEKVIRAGMSSHFRIPVYQNLSWREIGERLADEAAQFLGTSGGNNVKVFVADVASEETEKRIAECSKIEAVATQAVGSDIDLEDDSEETFEATFPASFRSFVSDPATATAYRLPLPSAPHFRISYFSAGPPVDETPSCKLPSEKIDFKPVLVVGSEVEGLSPEAYYLAHLTGGSRIVIPSSPDTESLNVLAATSTILGEMQRQYLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWJ3</accession>
    <name>A0A074ZWJ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164739.1">
        <property type="nucleotide sequence ID" value="XM_009166475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWJ3"/>
    <dbReference type="STRING" id="6198.A0A074ZWJ3"/>
    <dbReference type="GeneID" id="20316459"/>
    <dbReference type="KEGG" id="ovi:T265_02271"/>
    <dbReference type="CTD" id="20316459"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="18233" checksum="23647B6018BFA27A" modified="2014-10-01" version="1">MKGFAFIEFEDPRDAEDAHYNMDHTRFMGRDIEVEFTRGYRKTPAEMRLKERRDGGRGPPGRRGRSRSRSRSRSASRRGRSEYNGRRSSDRRDDSRRRVTDARRSASRSRSPTRSRSPSHNGVEDGKGSRRHDRRDARASQSPRRRGSGSRSRSGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXQ4</accession>
    <name>A0A074ZXQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_04955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168096.1">
        <property type="nucleotide sequence ID" value="XM_009169832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXQ4"/>
    <dbReference type="GeneID" id="20319137"/>
    <dbReference type="KEGG" id="ovi:T265_04955"/>
    <dbReference type="CTD" id="20319137"/>
    <dbReference type="OrthoDB" id="6264340at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER28115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="472" mass="52488" checksum="021A8BE03E51487F" modified="2014-10-01" version="1">MFNSALNWVQEGVSRKDFECKDKRTVYWFTAKEGSQVIHFISAADFHVRPPAIIVLHSNFMDSTVSINCTAYEKNATFRNSVKVSAVTASYGLVLYELCDYIDIGDKAELPPDTDCHNYFGSNLDWELKDAMPNSANEVTVSFIGTKLNDSGDLFLPGGSVKVQFTVYAKDTKPYDAFYYEVAGGLCVEVRIVIDRLKAKNEQTRVAPVLLVFSNQSMEDDDDFVQVSGYSRTMFDGPLGKLPSQYILLDKRVKAGQMGHDTPPAYIQSVPVSITNPDPVGASHSLRLANLAYRKLVKHSSTAKKYSRSLVYAYYGDRFNQVHQGSHEGYVGAREQFVNLGTPKDGFYVASNYSAWTLLLHLGTPDLQPTGSQNPAVVASLTIVGLAVVAGGAGVAYRRRRQLLAQQLVHRVEPQFGEPVATTVRERMDPVEPFQRRKMFSLFRNRRPGETSTEPLLTDPPPSYDSVSNTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXU6</accession>
    <name>A0A074ZXU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165436.1">
        <property type="nucleotide sequence ID" value="XM_009167172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXU6"/>
    <dbReference type="GeneID" id="20317016"/>
    <dbReference type="KEGG" id="ovi:T265_02828"/>
    <dbReference type="CTD" id="20317016"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12939" checksum="3D7315D879C46193" modified="2014-10-01" version="1">MTEIIGRLFEFTPYGVRFFVAWNVNGAALYNEKSHNKPDVEVVGAEKEELAGPCGKEDSPESEGSEIQDVFSYIHGARYKEGRNVTHGLRAQQEEMNTNIYPKREVNERKQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYH3</accession>
    <name>A0A074ZYH3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165169.1">
        <property type="nucleotide sequence ID" value="XM_009166905.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYH3"/>
    <dbReference type="GeneID" id="20316795"/>
    <dbReference type="KEGG" id="ovi:T265_02607"/>
    <dbReference type="CTD" id="20316795"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="145912" checksum="2F8D2CEF0C14BAFC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14802" checksum="7BEA0DEC76E99E2F" modified="2014-10-01" version="1">MKTQMLPAYAGGVVAAHSPRMSNFELPHEQGDALLMSSNKSEARVQCSPLWCVRTMIHTKMAWNGSDSVYALLMRIHKPRHKELREVGSTKVTSRNPERSTTEVTKVSIRARRQKKPSSHFTWSSINHDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZI5</accession>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN0</accession>
    <name>A0A074ZZN0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009177369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN0"/>
    <dbReference type="STRING" id="6198.A0A074ZZN0"/>
    <dbReference type="GeneID" id="20325043"/>
    <dbReference type="KEGG" id="ovi:T265_10875"/>
    <dbReference type="CTD" id="20325043"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="9030" checksum="B2A5C60D9B2F1235" modified="2014-10-01" version="1">MKQETLHRGLLKLFSIVDLDGDNRVSYNELNLGFERFGFTERQIKGGKKDKNTDGPSGYDVVTDRRSCLIVPTMKRVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZS7</accession>
    <name>A0A074ZZS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167501.1">
        <property type="nucleotide sequence ID" value="XM_009169237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZS7"/>
    <dbReference type="STRING" id="6198.A0A074ZZS7"/>
    <dbReference type="GeneID" id="20318670"/>
    <dbReference type="KEGG" id="ovi:T265_04488"/>
    <dbReference type="CTD" id="20318670"/>
    <dbReference type="OrthoDB" id="302770at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12694">
        <property type="entry name" value="RRM2_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12424">
        <property type="entry name" value="RRM3_hnRNPL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006536">
        <property type="entry name" value="HnRNP-L/PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021790">
        <property type="entry name" value="PTBP1-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01649">
        <property type="entry name" value="hnRNP-L_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13893">
        <property type="entry name" value="RRM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11835">
        <property type="entry name" value="RRM_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="222"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="434" mass="48756" checksum="ED0D2348C0CAFF9B" modified="2014-10-01" version="1">MLDLREFSMGMFSDEPLRIGEHNIDVSFSTSKHVMQRASSKETSPDPSDPLSTVNHVLLYTVFNVQHPVTLKVIHQITSMFAEVVRIVMFRKSNIQAMVEFKSVEDARRVKQNLNGADIYSGCCTLKVDYARPTRLTVKRNDEDTWDFENNGATDAEPDDSFGSSRRMHGSLLGSYPKHDMGPPHANGSFHTPSFQTPPGRSLMRLPVTPDSSRYHPHPPTPVAMVFNLNPDEMNCERLFNLFCPYGNVLRVKFLHSTQGTAMVEMGDPESVDRLMDNLSGYTLMGSQLVIRRSKQNEVLNNTLPHKLFDGSPSFQDFSSSRNNRYTTMASASKNRLFKPSSTLHYWNCPLGFNLDDMRAICENLHAPLPSKFAAYTKGSGRSSSGLVQWDNESDALAALAIVNHHEIPNPDDGRHTFILKLSFAAESIRDTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0K5</accession>
    <name>A0A075A0K5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163060.1">
        <property type="nucleotide sequence ID" value="XM_009164796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0K5"/>
    <dbReference type="GeneID" id="20315089"/>
    <dbReference type="KEGG" id="ovi:T265_00901"/>
    <dbReference type="CTD" id="20315089"/>
    <dbReference type="OrthoDB" id="10327945at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="22537" checksum="9D86EE94011F6F1E" modified="2014-10-01" version="1">MIPVYPVAQPLVEVHCSSHRTVLTWDGLWTASTASSNPRDAGFLNSKTRVSNNLSKWTDSGYNSFGTPGQCQTKQRSNSSSGRPDFSIESLLADDCPVENERLYTKPLFQLQNIVGVQSPFTTQTQDIPIDLSMQTSGLWHRVKRSEDKCGIPNFSCRYCGKPYNSRSSSRSVNLLCVFERKQCIPSAILSQLDPSLKSKPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Z7</accession>
    <name>A0A075A0Z7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596995">
        <property type="protein sequence ID" value="KER21084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175167.1">
        <property type="nucleotide sequence ID" value="XM_009176903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Z7"/>
    <dbReference type="GeneID" id="20329333"/>
    <dbReference type="KEGG" id="ovi:T265_15168"/>
    <dbReference type="CTD" id="20329333"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10311" checksum="68AF0CE8A195F9F1" modified="2014-10-01" version="1" fragment="single">MIGANSLVIELDPGRLVQLQWQDPALRMVVPAFLNLTSPNVSIIGNFHLFIVLMEYQDQTNQEKESHILVFQLTRVAAEDIANPKRLDLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M2</accession>
    <name>A0A075A1M2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163085.1">
        <property type="nucleotide sequence ID" value="XM_009164821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M2"/>
    <dbReference type="GeneID" id="20315114"/>
    <dbReference type="KEGG" id="ovi:T265_00926"/>
    <dbReference type="CTD" id="20315114"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A250</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A250"/>
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    <dbReference type="KEGG" id="ovi:T265_10213"/>
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    <dbReference type="OrthoDB" id="6271936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="928" mass="102914" checksum="1F897F600FFC542C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Q6</accession>
    <name>A0A075A2Q6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase A2</fullName>
            <ecNumber evidence="1">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162168.1">
        <property type="nucleotide sequence ID" value="XM_009163904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Q6"/>
    <dbReference type="STRING" id="6198.A0A075A2Q6"/>
    <dbReference type="GeneID" id="20314384"/>
    <dbReference type="KEGG" id="ovi:T265_00196"/>
    <dbReference type="CTD" id="20314384"/>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="10">
        <location>
            <begin position="726"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="865"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="730"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="762"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="961"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="670"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1110" mass="122526" checksum="E052F5A8B193E98D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2W4</accession>
    <name>A0A075A2W4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="GeneID" id="20326745"/>
    <dbReference type="KEGG" id="ovi:T265_12577"/>
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    <dbReference type="OrthoDB" id="6264573at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <dbReference type="GO" id="GO:0046983">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="41730" checksum="02C74C0FB6B7E765" modified="2014-10-01" version="1" fragment="single">MRIEKSLEFRSADLQVFGTSTLEEPTEGLLKIIGISNGNFPPYLKLPRNNFIIVDLPTVSMSLALLFTTCHLNSAHPQRRSPYGASATDHRTADGREIVSGIGHPCWDLHTASIGVTSAKEHKMANKSLAMSSAPLQPRVNQKASVAHGEQTEPHAVVRFSRRGRRSTVPPEQREQIRRLKKQNMERRRRACITDKMNALHNLAMDLIGEDPKQYQKTEKADLLNICYAVFENVVSIVKEQPEIQLRIQQLSDQFRDKNTPESNHTGQNTMSIQAIGKRWEESEQKENQNNESLDHIQPLREDVSAIRPSNTHRLTPMRQNQTCNSAPKHKFLPFITDSLDSGIYNSDRSLDQSGGHLLPNFQDTFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3D3</accession>
    <name>A0A075A3D3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161954.1">
        <property type="nucleotide sequence ID" value="XM_009163690.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A3D3"/>
    <dbReference type="GeneID" id="20314221"/>
    <dbReference type="KEGG" id="ovi:T265_00033"/>
    <dbReference type="CTD" id="20314221"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="574"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="661"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="132146" checksum="4C82AF72BA750C39" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3I6</accession>
    <name>A0A075A3I6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162001.1">
        <property type="nucleotide sequence ID" value="XM_009163737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3I6"/>
    <dbReference type="GeneID" id="20314268"/>
    <dbReference type="KEGG" id="ovi:T265_00080"/>
    <dbReference type="CTD" id="20314268"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14329" checksum="292DAAD6621D40E0" modified="2014-10-01" version="1">MKACNEVVKLQRSDLSCQNNCEQEVTQVFLGTHREKLEAIIAQCDIASMDLSKGGASTKLFRSMMQPKSVHRQKLLPLGSLPSAGKKTHRREHNNYIPNKRVRGRECENTTALSQLLEGHCLNLVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3M6</accession>
    <name>A0A075A3M6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163388.1">
        <property type="nucleotide sequence ID" value="XM_009165124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3M6"/>
    <dbReference type="STRING" id="6198.A0A075A3M6"/>
    <dbReference type="GeneID" id="20315351"/>
    <dbReference type="KEGG" id="ovi:T265_01163"/>
    <dbReference type="CTD" id="20315351"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="29419" checksum="7F48C46DA1D78E41" modified="2014-10-01" version="1">MAVGGQKSGSKGGKKGGKKKTADPFTKKEWYDIKAPSMFHKRTCARTLVTRTQGTKIASEALKGRVVTLSLGDLSEKNEETFRKFKLQVEDVQGRHCLTNFHGLEITRDKLCSLVVRWRSTIEAHVDVKTTDGYHLRFFIISFTPNPKSARHECRHTYAQATRVKRLRARLVEVIQQEVSSCDLKEVVNKLIPDSIAQDARKAASWIYPQADTIIRKVKVLKKPKLDIGRLMELHGESKDAAPGEGVTRPDHYEPPQVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3V6</accession>
    <name>A0A075A3V6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166031.1">
        <property type="nucleotide sequence ID" value="XM_009167767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3V6"/>
    <dbReference type="STRING" id="6198.A0A075A3V6"/>
    <dbReference type="GeneID" id="20327377"/>
    <dbReference type="KEGG" id="ovi:T265_13210"/>
    <dbReference type="CTD" id="20327377"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65270" checksum="37B75CDE46F8AD7B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A449</accession>
    <name>A0A075A449_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">microtubule-severing ATPase</fullName>
            <ecNumber evidence="10">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_12427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162107.1">
        <property type="nucleotide sequence ID" value="XM_009163843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A449"/>
    <dbReference type="STRING" id="6198.A0A075A449"/>
    <dbReference type="GeneID" id="20326595"/>
    <dbReference type="KEGG" id="ovi:T265_12427"/>
    <dbReference type="CTD" id="20326595"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="229"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="54734" checksum="6D720298FAAAACD9" modified="2014-10-01" version="1" fragment="single">VPSEATVLQGKEIKHRETRFVVHGFEAGNHSRGGPLDTLNEGDVFLRESFGRDGKKYLSSSNITAKPDKENYAEARKLYLDAIVLFDKVVCSSKDATVQGRSKEFKDSAYQRVKFIVLPFLVWFHENDCARTGRRWLKRESYEHYQKQLAASSAEKKSSRTLPSKDTILRKVKNVSSSAVTRILNEVVEDCSSVTLADVAGNDRAKQLLTEAVILPTLRPELFTGLREPVRGVLLFGPPGNGKTMLAKAVSSESNCIFFNISAASLLSKWVGESENTVKALFAVAREVSPSIIFLDEVDSLLAARRADGGHEVSRRVLTQILAEMDGVQSGSERVLVLAATNRPQELDDAALRRFPRRVYVRMPDMRTRQEMLLKLLGKNVNHSLSRTDVERIARGTEGFSASDLKELAKEAALQPIREISTTQLRTISEHEVRPLALKDFIQSLKFVRPSVSGTSLAPYESWNKQFGESNEPVVASQVASSTGIGKRLLGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4S1</accession>
    <name>A0A075A4S1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165704.1">
        <property type="nucleotide sequence ID" value="XM_009167440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4S1"/>
    <dbReference type="GeneID" id="20317238"/>
    <dbReference type="KEGG" id="ovi:T265_03051"/>
    <dbReference type="CTD" id="20317238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="9023" checksum="5087F9C790CE88A3" modified="2014-10-01" version="1">MYVHYSMQDSRERPAKRGINLKVVRFYSMASCHGLNSSSCTYLSDPVGDLRHHELYIFGTTFQACLRNLLYITDRGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A810</accession>
    <name>A0A075A810_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596843">
        <property type="protein sequence ID" value="KER23604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172646.1">
        <property type="nucleotide sequence ID" value="XM_009174382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A810"/>
    <dbReference type="GeneID" id="20322724"/>
    <dbReference type="KEGG" id="ovi:T265_08545"/>
    <dbReference type="CTD" id="20322724"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="11650" checksum="8309BE1F0DD3E6DA" modified="2014-10-01" version="1">MSPRMVTKRLQANCQARRTDQQPPDQQPINAMATFDCTGLGSTASGTEVCTLLVGTGVVLGCTGGCTFGVRVPPETTASGCKLVGILDVLVGTGATFGPTFAGLLVTGCPAVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8S5</accession>
    <name>A0A075A8S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164096.1">
        <property type="nucleotide sequence ID" value="XM_009165832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8S5"/>
    <dbReference type="STRING" id="6198.A0A075A8S5"/>
    <dbReference type="GeneID" id="20315930"/>
    <dbReference type="KEGG" id="ovi:T265_01742"/>
    <dbReference type="CTD" id="20315930"/>
    <dbReference type="OrthoDB" id="6254633at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="910" mass="101510" checksum="98806827A73A7CD2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9A4</accession>
    <name>A0A075A9A4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163862.1">
        <property type="nucleotide sequence ID" value="XM_009165598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9A4"/>
    <dbReference type="STRING" id="6198.A0A075A9A4"/>
    <dbReference type="GeneID" id="20315727"/>
    <dbReference type="KEGG" id="ovi:T265_01539"/>
    <dbReference type="CTD" id="20315727"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="74"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="32870" checksum="CCA01A7B20EECC58" modified="2014-10-01" version="1">MSLKFNTDDYVRVPLPSRLEANDSSDPELDGDIEPTVETTTTRTERVPNAWNIEFYQQHFDVDTHQVLRRLAFSVIPNPRSNFIQHVLKPRADLYGPFWIATTLILASAIGGNISSYLQSRGRLASWRYDFRKVTLASTVIYMYWWLVPLGIVAFFYMQSRKSNSSSDGEDQDPLVAQPHSRVRGRHTGVKAHNFVELLSVYGYSLTIFVPVSIAGPLIIGIVLLHCAFSVGLMMTFFPGSPSVVTTPVVAPVVPVSGAVPAGPVALDSAKADVPRAVPDPTLKDKEKIVDVQKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAW4</accession>
    <name>A0A075AAW4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171548.1">
        <property type="nucleotide sequence ID" value="XM_009173284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAW4"/>
    <dbReference type="GeneID" id="20321875"/>
    <dbReference type="KEGG" id="ovi:T265_07696"/>
    <dbReference type="CTD" id="20321875"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="13120" checksum="01AB3E1C465F8702" modified="2014-10-01" version="1">MPVAKGAFRTRQKFKKVIAAYAIYTKRSTTFLDFVLGINRPCAPLVVVLTTQEPIMAQYWPNAGCQWRIQNASEISESYNRLRYIDEALYDCTTDFVWGVNIPYVPLVVVFFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB89</accession>
    <name>A0A075AB89_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171328.1">
        <property type="nucleotide sequence ID" value="XM_009173064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB89"/>
    <dbReference type="STRING" id="6198.A0A075AB89"/>
    <dbReference type="GeneID" id="20321698"/>
    <dbReference type="KEGG" id="ovi:T265_07519"/>
    <dbReference type="CTD" id="20321698"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="329"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="529" mass="59072" checksum="1FCFB7D00BA7075D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD76</accession>
    <name>A0A075AD76_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162201.1">
        <property type="nucleotide sequence ID" value="XM_009163937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD76"/>
    <dbReference type="STRING" id="6198.A0A075AD76"/>
    <dbReference type="GeneID" id="20314417"/>
    <dbReference type="KEGG" id="ovi:T265_00229"/>
    <dbReference type="CTD" id="20314417"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="9">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="386"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="590" mass="65205" checksum="A2BB3E3BF254D955" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADH1</accession>
    <name>A0A075ADH1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170223.1">
        <property type="nucleotide sequence ID" value="XM_009171959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADH1"/>
    <dbReference type="GeneID" id="20328253"/>
    <dbReference type="KEGG" id="ovi:T265_14087"/>
    <dbReference type="CTD" id="20328253"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16534" checksum="CFEC07CCA3AF7937" modified="2014-10-01" version="1">MGFRLHPSNPTGPQFLCFHSCAEWIPRFNFILFSFQRERKVRGSNQIYASRLSLSRLGNLTLSQPLCFCQVAWQLGTERVLQLNILYKTIWKKTFSCNALPASSCHATQKKHEGWGTSRLSKPRQGSRGAEVGTSNLAVRFALLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF46</accession>
    <name>A0A075AF46_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168915.1">
        <property type="nucleotide sequence ID" value="XM_009170651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF46"/>
    <dbReference type="GeneID" id="20319781"/>
    <dbReference type="KEGG" id="ovi:T265_05599"/>
    <dbReference type="CTD" id="20319781"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="18536" checksum="D4C5A9B895B8BE0C" modified="2014-10-01" version="1">MPLLGTKKSRIVMTCLAGLPVTLRSNQLINGLRQEHILLTITEVTLQGLELRLTVAENSSAAQGRFHYSTGSSGRHSPTVSIGFTFHLNSNWALIVRYTHLQSNLILARNLIKPKLNLSFMGRRLDRLAQTTDTGQARTSSVLTASSEFSVCAVLRFPVRMSLARSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFI5</accession>
    <name>A0A075AFI5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168499.1">
        <property type="nucleotide sequence ID" value="XM_009170235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFI5"/>
    <dbReference type="GeneID" id="20319448"/>
    <dbReference type="KEGG" id="ovi:T265_05266"/>
    <dbReference type="CTD" id="20319448"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="236" mass="26643" checksum="6ED7DC480E72AFBA" modified="2014-10-01" version="1">MSVPSRADAARKTDARRTESSVLSVGPAIGELLLGLWEVDEKLVEPLNILMRLSVALDKSPSGLGVNGTKGDKMTPKSTEGQYRQPKVVENYMNIEPSYCYESIITQNTKLNVPSKLKRIFFEWKKNGFNPLEKDLQIIVVLGLNMDEYPTFRISIITGDIPPNKHSRIAAPIKAIFSQKQYSGKHRVLPPQTSPNEVSEDDYPTITFMPSDIVVPISAEVDQATHRWRFKTRWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFQ4</accession>
    <name>A0A075AFQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168227.1">
        <property type="nucleotide sequence ID" value="XM_009169963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFQ4"/>
    <dbReference type="GeneID" id="20319234"/>
    <dbReference type="KEGG" id="ovi:T265_05052"/>
    <dbReference type="CTD" id="20319234"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13477" checksum="517F0F4E00B27A9C" modified="2014-10-01" version="1">MILRTPRTFEVQVPALWVSEVASFVSCGLTKIIAPRQEGCSNVSGVDEFNRFWNDLHAHFVMFQWINRLRVCLTILNGARGTRTIHALTGGTTLAILTNLVTLQPHAKIDHGRTTLLVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGY3</accession>
    <name>A0A075AGY3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167070.1">
        <property type="nucleotide sequence ID" value="XM_009168806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGY3"/>
    <dbReference type="GeneID" id="20327588"/>
    <dbReference type="KEGG" id="ovi:T265_13421"/>
    <dbReference type="CTD" id="20327588"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="18581" checksum="CF10E7D80DF9EBAF" modified="2014-10-01" version="1" fragment="single">TVCRGTAVLALAISFTGDRSKNHAVAPTALSVKPNVTTVPNWKTSCVIDSLLAFTCSKYSRSCYAVRIRNFKLFGKYVEFKTRGQSVNGTPTASNTNEFFVGDLMVSEQNVVSEERNTCEEPEVFIPRRSERLWLRPPSTCSFRVCGNPYAVHIYADSNTCVLLVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHS7</accession>
    <name>A0A075AHS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165816.1">
        <property type="nucleotide sequence ID" value="XM_009167552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHS7"/>
    <dbReference type="STRING" id="6198.A0A075AHS7"/>
    <dbReference type="GeneID" id="20317326"/>
    <dbReference type="KEGG" id="ovi:T265_03139"/>
    <dbReference type="CTD" id="20317326"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20881" checksum="63A4D209E5D8C032" modified="2014-10-01" version="1">MLPKNLSHWLCAFGSSVVLYKYHSYVGTVVYCEGISMEPTVNHGDYLVVERISVLRGRIKKGDVVVAGQPRKSHNCSHVLKRIKALGEEQVTFWDEGHWRMVTREIPADHIWLEGDNSVHSLDSRTYGPVPLSHLEYRVLFRLWPLHQFGRLEPPKAIEASHPSLSRRPADSCADVVCLDAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI33</accession>
    <name>A0A075AI33_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165325.1">
        <property type="nucleotide sequence ID" value="XM_009167061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI33"/>
    <dbReference type="GeneID" id="20316934"/>
    <dbReference type="KEGG" id="ovi:T265_02746"/>
    <dbReference type="CTD" id="20316934"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9759" checksum="5CB94F452BA79FA4" modified="2014-10-01" version="1">MAQNYSSLNYIRENNFVWTIMIILLAVHRETATGGHEGGDLETEYAALQPNSSGAAEVGNPGTSSNVPRNSPTRKLLIFIKSSYLDDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI89</accession>
    <name>A0A075AI89_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165059.1">
        <property type="nucleotide sequence ID" value="XM_009166795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI89"/>
    <dbReference type="GeneID" id="20316720"/>
    <dbReference type="KEGG" id="ovi:T265_02532"/>
    <dbReference type="CTD" id="20316720"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="18393" checksum="2EEBB4A70CC495D8" modified="2014-10-01" version="1">MPVVDLLVHAGLFESGFLRNTIKEDLQESTYETKQTLDSQITRSKNTPSSHVVKGIKPPDSAILVVGPPASDGRITSRFASTVIFTTEYEIIRERWPKQFWVAPAQRQHSDETAAVMLLSKYCDLNDCPSLSSKFRLCTSGDEEATAAGYAKVGIVLSERAEASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI95</accession>
    <name>A0A075AI95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164950.1">
        <property type="nucleotide sequence ID" value="XM_009166686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI95"/>
    <dbReference type="GeneID" id="20316625"/>
    <dbReference type="KEGG" id="ovi:T265_02437"/>
    <dbReference type="CTD" id="20316625"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="9115" checksum="A82CAF8A835805A4" modified="2014-10-01" version="1">MKPASRTHSTRLTGMFFLEEFVLQGMFRKFMDIIISSLYSLTFERVKVYRKTVQKLAYTKWCPSGLLILSFPNGFPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIB1</accession>
    <name>A0A075AIB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164932.1">
        <property type="nucleotide sequence ID" value="XM_009166668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIB1"/>
    <dbReference type="GeneID" id="20327162"/>
    <dbReference type="KEGG" id="ovi:T265_12994"/>
    <dbReference type="CTD" id="20327162"/>
    <dbReference type="OrthoDB" id="6240643at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="33293" checksum="9583BCCF17625233" modified="2014-10-01" version="1" fragment="single">MRHMQAVSAESEQANGRIDTSLALASNNGDLELRNDTTESAQTVHSVLPWRQPNAEDVKTDCCTRAQVMCCTESKSNTTQTTSDETDTEPNLISWLTDSCMQSTTSNGQNHKLASVHCENEYIMHHRETTYAHHKHCLHLHLRQQPCSPPYGYSAAFSATENQKLAQSRLCSELPPSSSDAHINTPPDFGASHFRDLYPHHHHHYHYFHHHNSQRPLSLPREQISDAAVLPHTRTDRLVELPSMPGLLTQGKLKRFGDFHIQSRTETESEFEEALHSLKMRVWEWLNGVQDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJQ8</accession>
    <name>A0A075AJQ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162510.1">
        <property type="nucleotide sequence ID" value="XM_009164246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJQ8"/>
    <dbReference type="GeneID" id="20314661"/>
    <dbReference type="KEGG" id="ovi:T265_00473"/>
    <dbReference type="CTD" id="20314661"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9641" checksum="2CFD5441B716B67E" modified="2014-10-01" version="1">MAEELRRSISLFDKNLFNSENRDSYQFGLHQFCTAFIWYDDGITHSVGRGKTGRRERQPLTDKSKTDLGNVGKSLDPVYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW58</accession>
    <name>A0A074YW58_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597488">
        <property type="protein sequence ID" value="KER18918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177334.1">
        <property type="nucleotide sequence ID" value="XM_009179070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW58"/>
    <dbReference type="GeneID" id="20326266"/>
    <dbReference type="KEGG" id="ovi:T265_12098"/>
    <dbReference type="CTD" id="20326266"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="9940" checksum="4DEE757E29655B15" modified="2014-10-01" version="1">MKKELSNQETSTKSTAFRIKFTNSQALTMLVIQVDFDSTGLCCDNKLAGVEYLFIASALCAAGASSAQQYLGRQLTKTVEQLALRPGDPASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYF0</accession>
    <name>A0A074YYF0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606157">
        <property type="protein sequence ID" value="KER18212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178041.1">
        <property type="nucleotide sequence ID" value="XM_009179777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYF0"/>
    <dbReference type="GeneID" id="20326507"/>
    <dbReference type="KEGG" id="ovi:T265_12339"/>
    <dbReference type="CTD" id="20326507"/>
    <dbReference type="OrthoDB" id="6614841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17813" checksum="6E65A7489B9C7A53" modified="2014-10-01" version="1">MYESSFFFFLGLSYGFVQIGVQQFKVMFDTGGFSRWIPSSRSAADHFPNRVKYDENSPTRTSLEKQYVVSYSGEQYEGNVVMDNILIAGQSVEQFTFVEMICSSITVDASVGHDGIFGMSKPSKGRRRWEIFEVNLLDHFLAVGTVQEAVFTFRFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0F6</accession>
    <name>A0A074Z0F6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597048">
        <property type="protein sequence ID" value="KER20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175739.1">
        <property type="nucleotide sequence ID" value="XM_009177475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0F6"/>
    <dbReference type="STRING" id="6198.A0A074Z0F6"/>
    <dbReference type="GeneID" id="20325121"/>
    <dbReference type="KEGG" id="ovi:T265_10953"/>
    <dbReference type="CTD" id="20325121"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="22512" checksum="0B1A6CC57D8F51E5" modified="2014-10-01" version="1">MLRRSLVDFLCPALSRYAIWSQQKPQCANIHMSSTNQDWIRRNTPRKPVLYKIPKVYTLLEEEMIDTVLPKPEVPVDEKLVQSVINSVNSSITENRSRYFAVVHLAGKQFKVTTDDLIMVKTPLFGTEVGDRIRLEKVLLLGSNEFTLIGRPLLSNQQVYVEAQVVEKTLEHPKLWFQFHRRRRHRRMRGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3M2</accession>
    <name>A0A074Z3M2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596952">
        <property type="protein sequence ID" value="KER21633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174609.1">
        <property type="nucleotide sequence ID" value="XM_009176345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3M2"/>
    <dbReference type="GeneID" id="20324245"/>
    <dbReference type="KEGG" id="ovi:T265_10077"/>
    <dbReference type="CTD" id="20324245"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="11066" checksum="8162995D6C22C532" modified="2014-10-01" version="1">MMLFERPSSSGWVILEIRDYEIYSPQSNLLTDAVTTALSYAQSFLRPFELRKYPFWTTWLADTHSTWPMIYNSGIAERTTNNPAIPYRPRSTLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Y2</accession>
    <name>A0A074Z3Y2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL615785">
        <property type="protein sequence ID" value="KER18035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178218.1">
        <property type="nucleotide sequence ID" value="XM_009179954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Y2"/>
    <dbReference type="GeneID" id="20330508"/>
    <dbReference type="KEGG" id="ovi:T265_16343"/>
    <dbReference type="CTD" id="20330508"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="57" mass="6072" checksum="4807B08100271231" modified="2014-10-01" version="1" fragment="single">VITYLPGLVAHVRIGAAKGTTERTGGPGRTHDYSEQLPIRGSSACRSPDQVRHGWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4B7</accession>
    <name>A0A074Z4B7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL609765">
        <property type="protein sequence ID" value="KER18130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178123.1">
        <property type="nucleotide sequence ID" value="XM_009179859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4B7"/>
    <dbReference type="GeneID" id="20330439"/>
    <dbReference type="KEGG" id="ovi:T265_16274"/>
    <dbReference type="CTD" id="20330439"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="38" mass="4123" checksum="06D8BEEC0B254BCA" modified="2014-10-01" version="1" fragment="single">ADEATDLTSPSPTSKFRADRFRAGRQSKDGRMSAYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4J5</accession>
    <name>A0A074Z4J5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606557">
        <property type="protein sequence ID" value="KER18200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178053.1">
        <property type="nucleotide sequence ID" value="XM_009179789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4J5"/>
    <dbReference type="STRING" id="6198.A0A074Z4J5"/>
    <dbReference type="GeneID" id="20326511"/>
    <dbReference type="KEGG" id="ovi:T265_12343"/>
    <dbReference type="CTD" id="20326511"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11185" checksum="A9592E0BB1E168F8" modified="2014-10-01" version="1">MGVHETHTDSTGELALSSNSTDDEQDVLKPTTTETFGDRTKKLCTRFAGLMSNLVNTVSLARMDYYLSLVCQGASECITEARQQLINPGLPLGVAGADAPGHLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z518</accession>
    <name>A0A074Z518_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597037">
        <property type="protein sequence ID" value="KER20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175626.1">
        <property type="nucleotide sequence ID" value="XM_009177362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z518"/>
    <dbReference type="STRING" id="6198.A0A074Z518"/>
    <dbReference type="GeneID" id="20325037"/>
    <dbReference type="KEGG" id="ovi:T265_10869"/>
    <dbReference type="CTD" id="20325037"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703908" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="16591" checksum="8DCF4493D2421324" modified="2014-10-01" version="1">MPVSFILICGAVFCVPCLAYSVSYTDCGSTGIFVVSVDIEPCNREPCKLIKGTSVIRAGGANIQGLYPAGPVRIPLQRNGICAQLVPTCPIEAGGVYTYQVARTMPNNVPDVSHNLKLGALASACFGPMTIRWELLIDSGLPFLCIELSVEIAVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5J8</accession>
    <name>A0A074Z5J8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597020">
        <property type="protein sequence ID" value="KER20802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175466.1">
        <property type="nucleotide sequence ID" value="XM_009177202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5J8"/>
    <dbReference type="GeneID" id="20329407"/>
    <dbReference type="KEGG" id="ovi:T265_15242"/>
    <dbReference type="CTD" id="20329407"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13173" checksum="B785E8D7AF8417D0" modified="2014-10-01" version="1" fragment="single">MQDCHSVKDFHKKLFLLRMGDSRCSLINSKIGDKSQLQQTEDGDVYGSDQVDVPSGPNTEQYGCVIWENALNFSNHGCRKPRGGQHMTWQKGVKEITKSLGAVGVVRLPGWGPRDPVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5W5</accession>
    <name>A0A074Z5W5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial glutamate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597008">
        <property type="protein sequence ID" value="KER20932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175306.1">
        <property type="nucleotide sequence ID" value="XM_009177042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5W5"/>
    <dbReference type="STRING" id="6198.A0A074Z5W5"/>
    <dbReference type="GeneID" id="20324788"/>
    <dbReference type="KEGG" id="ovi:T265_10620"/>
    <dbReference type="CTD" id="20324788"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="88"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="258"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44460" checksum="57009037F1701413" modified="2014-10-01" version="1">MPCDGRAININSSAVTLSVPSCHATRRKQEGWDTARLSKPRQGKSRGRGRIRTTDLPVSKFALLPLGPSRPMGRHPRPGQNVACASSVPFIPKVVNGGIAGIVGVTCVFPIDLVKTRLQNQQEGSRMYKNFCNTLSVPSRHATRKKHEGWDTARLPKPRQGKSRDRSRVRTMDLLATAMQPEGSMRAGIPPVEKQRSGSNHGPSGHLDCASKTYRAEGFFGMYRGSGVNLLLITPEKAIKLVGNDFFRYHLKQEGKSLTPFREMLAGAGAGTCQIIVTTPMELLKIQLQDAGRTASGLEANGLVSVRRTSATQLALQLVRERGIFGLYRGMAATFLRDVSFSMIYFPLFANFNALGPRRAPGSVEAVFYWSFGSGFTAGMIAAFAVTPCDGEFFYDICGVFFHLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z764</accession>
    <name>A0A074Z764_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596872">
        <property type="protein sequence ID" value="KER22938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173325.1">
        <property type="nucleotide sequence ID" value="XM_009175061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z764"/>
    <dbReference type="STRING" id="6198.A0A074Z764"/>
    <dbReference type="GeneID" id="20328916"/>
    <dbReference type="KEGG" id="ovi:T265_14750"/>
    <dbReference type="CTD" id="20328916"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="23197" checksum="F630A4BD4993A1F5" modified="2014-10-01" version="1" fragment="single">RLTWNPAAFLVCDVLRQLNVLHQAASCFRRYDIRDTAIHVYLCNALLIRLLGCRRIFSNLMSIYYCIGDETQNWIKKSFSCNTLPVPSCHSTRRKHEGWDTARLPKPRQEKSRGRGRVRTTDLRFKGALVQLNVRFSANRTGDCVYKIKCDDCTKVHMGRAVRTLLTKIAQHTQARNADKYRALLKDLAMAEQVLARDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7X1</accession>
    <name>A0A074Z7X1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metal cation transporter, ZIP family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173059.1">
        <property type="nucleotide sequence ID" value="XM_009174795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7X1"/>
    <dbReference type="STRING" id="6198.A0A074Z7X1"/>
    <dbReference type="GeneID" id="20323052"/>
    <dbReference type="KEGG" id="ovi:T265_08873"/>
    <dbReference type="CTD" id="20323052"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703963" description="Metal cation transporter, ZIP family" evidence="8">
        <location>
            <begin position="31"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65686" checksum="9F3816939CD4DDC5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z872</accession>
    <name>A0A074Z872_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596943">
        <property type="protein sequence ID" value="KER21752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174492.1">
        <property type="nucleotide sequence ID" value="XM_009176228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z872"/>
    <dbReference type="GeneID" id="20324159"/>
    <dbReference type="KEGG" id="ovi:T265_09991"/>
    <dbReference type="CTD" id="20324159"/>
    <dbReference type="OrthoDB" id="6244833at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="29118" checksum="4CD9BE7A95A0E80C" modified="2014-10-01" version="1">MSEHWCCYCCEPEEEIMDIEVVEDGDALQEYGVNRTLQLLRSMINQGGRPIIDQPPPAYKDFAKYPLAAEMEDKPSMMQTTGSGWYPTITQVQRTANSSDPRPSTWMEPFPKPPGEPPPVPQNWFFTRLASIRRSLMAHFSPSRMASTVLRDTTPTESVSNLPANAVVSRELIENSQQRGMTAVQTNAPYSSLTEAPNRLSSPVRPNNDRNTPFVRTVQLPRESYPTRARVNLTHSRSCEDMGSAREPIEGADRQTMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8T1</accession>
    <name>A0A074Z8T1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclic nucleotide-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_09823</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174270.1">
        <property type="nucleotide sequence ID" value="XM_009176006.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z8T1"/>
    <dbReference type="GeneID" id="20323991"/>
    <dbReference type="KEGG" id="ovi:T265_09823"/>
    <dbReference type="CTD" id="20323991"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="136"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="478"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="603"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1538"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1594"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="9">
        <location>
            <begin position="962"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="9">
        <location>
            <begin position="989"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1483"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1600"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1619" mass="180517" checksum="CEAADCA9563645AD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F9</accession>
    <name>A0A074Z9F9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597122">
        <property type="protein sequence ID" value="KER19885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176369.1">
        <property type="nucleotide sequence ID" value="XM_009178105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9F9"/>
    <dbReference type="STRING" id="6198.A0A074Z9F9"/>
    <dbReference type="GeneID" id="20325617"/>
    <dbReference type="KEGG" id="ovi:T265_11449"/>
    <dbReference type="CTD" id="20325617"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25413" checksum="44D9D9CCFAEC4D2C" modified="2014-10-01" version="1">MEYDRMYVTKDANPLKTVAPLILVSTEWFTKPQLEKHLSEEITDTQYEQWLVLMNRIAAQPLASMANSFISRFRANQIVVGATEKYPDPEIDPVTKQRFIKAYGQKRHCFAEATVYMPGSGQFTVNGKRLLERFPELGNREQIMFPLQLTKTLGQVDIVATVTETGTSSPANALRLAISRCLASLLPPETGRQRLCVSGLLIQDDRFAERKNPGQKKARKKPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA42</accession>
    <name>A0A074ZA42_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596827">
        <property type="protein sequence ID" value="KER23998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172254.1">
        <property type="nucleotide sequence ID" value="XM_009173990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA42"/>
    <dbReference type="GeneID" id="20322422"/>
    <dbReference type="KEGG" id="ovi:T265_08243"/>
    <dbReference type="CTD" id="20322422"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11394" checksum="7E1E6998685CA1A5" modified="2014-10-01" version="1">MARWFKWLGRGFTDRKVLGSNPTSASRFFLSMLEQPGSIPPLVFPSGGVAIRHVEATLGTRAKRRHALIGRNASQSGSTISDSTLLAPSRRFRPDLTEHSVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA72</accession>
    <name>A0A074ZA72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597088">
        <property type="protein sequence ID" value="KER20135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176123.1">
        <property type="nucleotide sequence ID" value="XM_009177859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA72"/>
    <dbReference type="GeneID" id="20325419"/>
    <dbReference type="KEGG" id="ovi:T265_11251"/>
    <dbReference type="CTD" id="20325419"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49941" checksum="4A05C7084D5F0CC0" modified="2014-10-01" version="1">MLSKGGHTFLVSNGTVFCTLGVVISGLSTLTVVPILRSTIGVPWIAFFFADASDCGVFSLSPTIFFDPLVLLLAADGYERLTLLLLLVRLLSLLLLRLRERSGTRAAGVFVNGVRLRGKRLFKEPSLVRASEDGRLCTAVDCCEVICLRTERNGVAVVSRALEIQWSAGGEGVRPSTGGLKTGGEHSTAGSEVCSGGGASEQDTTASFAVCGTIFAALPLLSLVLASVVEGFGVDIVTARAEPMKDRIALPEFDERCRGRARDSFGELERLELDEPDFFAELLSFGRFASSFLATREVIAPSEGLERLRISIAFPLLSVTFLGVEVFCRTEKRFRLIPTELVGVCTAASSSEESQETCEQEGFFLDLDLTASVERTLSEREALYCRLVARQFFVPRRVCIAVSPQGAEPGSRRSMLGIAEGNTTKAGVNRRRASASEELTETFPVLFEGEGMVSGRKDSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAA7</accession>
    <name>A0A074ZAA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596819">
        <property type="protein sequence ID" value="KER24191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172047.1">
        <property type="nucleotide sequence ID" value="XM_009173783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAA7"/>
    <dbReference type="GeneID" id="20322263"/>
    <dbReference type="KEGG" id="ovi:T265_08084"/>
    <dbReference type="CTD" id="20322263"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13015" checksum="2BA1074DDADCBFAE" modified="2014-10-01" version="1">MLSKAQCALAQSRLAHQAQSDRHTGSGVRLNGKNVPSTPCATHKSVISTQGAHNGKQTQVGARWTKWLDRESTDRTVRGSNPTSASRLPLSRLGRPGNIPALVPPSCGTHLGAERVLQLNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAN6</accession>
    <name>A0A074ZAN6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597071">
        <property type="protein sequence ID" value="KER20290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175971.1">
        <property type="nucleotide sequence ID" value="XM_009177707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAN6"/>
    <dbReference type="STRING" id="6198.A0A074ZAN6"/>
    <dbReference type="GeneID" id="20325300"/>
    <dbReference type="KEGG" id="ovi:T265_11132"/>
    <dbReference type="CTD" id="20325300"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="2">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="247" mass="27413" checksum="F470C356B02B99F8" modified="2014-10-01" version="1">MTDAGFFKGQGTSAEQDARFADKKKKLMKTMKFGDNLSQKVDMARVKLECIRPWIIKRITELLNFEDEVVCDYVFNQLEERHPDPKEIQINITGFLNSKNARVFLTELWDLLLSAMENPEGVPSLLLDAKKAEILQRQGEDKRVQQELSRQENVRAKNAAANNKASNISVACNQLVPDTQLNGSSQRISSTTPMEIEESTAMGSGIVGSSSLKAPSELGFGVARYASRNLYKISSVGPSPWTSEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAU6</accession>
    <name>A0A074ZAU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172035.1">
        <property type="nucleotide sequence ID" value="XM_009173771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAU6"/>
    <dbReference type="GeneID" id="20322255"/>
    <dbReference type="KEGG" id="ovi:T265_08076"/>
    <dbReference type="CTD" id="20322255"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19224" checksum="F0F104159036F587" modified="2014-10-01" version="1">MKHSISTRVKSTQSVTTTATNGQKPSSFNFIARFRSNRAVLPNSSMPLRPDGQPSQHHRPYFHAYNRNLTSNGIVITTRTAESHPHGSLPSERNPAIIRLSDTSPFQTDQFIYLFTQANHCFLTYGLNPAIFTGGYLVDCIHNHDADFMDKSADFTQVPPMLPQLLMVSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBD8</accession>
    <name>A0A074ZBD8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171626.1">
        <property type="nucleotide sequence ID" value="XM_009173362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBD8"/>
    <dbReference type="STRING" id="6198.A0A074ZBD8"/>
    <dbReference type="GeneID" id="20321936"/>
    <dbReference type="KEGG" id="ovi:T265_07757"/>
    <dbReference type="CTD" id="20321936"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="194"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="12">
        <location>
            <begin position="662"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115604" checksum="46A1041E8EF1861E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBN4</accession>
    <name>A0A074ZBN4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596869">
        <property type="protein sequence ID" value="KER23017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173250.1">
        <property type="nucleotide sequence ID" value="XM_009174986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBN4"/>
    <dbReference type="STRING" id="6198.A0A074ZBN4"/>
    <dbReference type="GeneID" id="20323204"/>
    <dbReference type="KEGG" id="ovi:T265_09025"/>
    <dbReference type="CTD" id="20323204"/>
    <dbReference type="OrthoDB" id="10050666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="144"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="28295" checksum="01B081DCC9B67439" modified="2014-10-01" version="1">MLDSYDDSVVDVQVDPQDKVKIYLAGIVSSTPIQAFDGNSRWCWRFIQQFKYYIEDRVQDSGQRMLYLIHYCRGPAKEAVAECPGLTPNDLLILNNRVHGVVPESMTERYTRGWQKVNYLTRVFWKHWVKEYIPLLQERYTRGWQKVNYLTRVFWKHWVKEYVPLLQARTKWQKPQRNFRKGDVVLVQSGASSREQWPGGVVDECETSDDGLVKTVVVRTMIDRLRRDVRKIGLIESYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBQ0</accession>
    <name>A0A074ZBQ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171555.1">
        <property type="nucleotide sequence ID" value="XM_009173291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBQ0"/>
    <dbReference type="GeneID" id="20321882"/>
    <dbReference type="KEGG" id="ovi:T265_07703"/>
    <dbReference type="CTD" id="20321882"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7027" checksum="E27C8F90D89CD15E" modified="2014-10-01" version="1">MTIYGCPTRGYSTTTTVENDFVQDIRLINEGLSRCSLLSTFVAGRKEAGFLQPRHIPKPALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBQ6</accession>
    <name>A0A074ZBQ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171517.1">
        <property type="nucleotide sequence ID" value="XM_009173253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBQ6"/>
    <dbReference type="GeneID" id="20321853"/>
    <dbReference type="KEGG" id="ovi:T265_07674"/>
    <dbReference type="CTD" id="20321853"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="12915" checksum="FC8B2ED56F569557" modified="2014-10-01" version="1">MYCPFINAFDDSITQPHTDRQLLTYSGARGCVKKRRRKRNVCPSTIIIVIITSVFNTDASLPYNHDLSESLIVKEGIKADGGGVLAYHNHSEVPTPPDIYAGNLDRNSKNSTGSHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDJ8</accession>
    <name>A0A074ZDJ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171034.1">
        <property type="nucleotide sequence ID" value="XM_009172770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDJ8"/>
    <dbReference type="GeneID" id="20328419"/>
    <dbReference type="KEGG" id="ovi:T265_14253"/>
    <dbReference type="CTD" id="20328419"/>
    <dbReference type="OrthoDB" id="6224711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="330" mass="36888" checksum="8743395ED731F4AA" modified="2014-10-01" version="1">MSRLISKVFCLTSYDGIEDTFQNFADHSLADIVSDFHLTTLMDDDFIAGFCTKGDVTILPLEASTAFDFSVEKWFRLDLRTPKFRRNSRLHQRLKGFLKASLDPIDSIRVPPDVLKPRPCLVCWSPRVEPTPHSESRSTPLPQSLAAHLTKNKYFKLRPTLTVERWSEPVHLPNLFDSPFDDQPGSDVNPDSARLAYTILSGLATGIVPPPSQSVAVQPNPCVCEPRLAPLFSLNIREATSLGTPYQNPVLIQLTGLFMPGQVDELEGTIRQIIKQRSNSRGFLFFATQPFSLGRSCNPCSADEYNVVARLFISDPAQKSPFVTINFKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE04</accession>
    <name>A0A074ZE04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596968">
        <property type="protein sequence ID" value="KER21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174829.1">
        <property type="nucleotide sequence ID" value="XM_009176565.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZE04"/>
    <dbReference type="GeneID" id="20324417"/>
    <dbReference type="KEGG" id="ovi:T265_10249"/>
    <dbReference type="CTD" id="20324417"/>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1507"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1601"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1682"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1444"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1785"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="312"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="453"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1836"/>
            <end position="1854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1890" mass="206584" checksum="A87A9E398A639ECB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEQ4</accession>
    <name>A0A074ZEQ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kringle domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174563.1">
        <property type="nucleotide sequence ID" value="XM_009176299.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZEQ4"/>
    <dbReference type="GeneID" id="20324213"/>
    <dbReference type="KEGG" id="ovi:T265_10045"/>
    <dbReference type="CTD" id="20324213"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705413" description="Kringle domain protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="7">
        <location>
            <begin position="462"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="951"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="145602" checksum="C1E9BFE1803C7767" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFG1</accession>
    <name>A0A074ZFG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL596927">
        <property type="protein sequence ID" value="KER21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174276.1">
        <property type="nucleotide sequence ID" value="XM_009176012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFG1"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20323994"/>
    <dbReference type="KEGG" id="ovi:T265_09826"/>
    <dbReference type="CTD" id="20323994"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="503" mass="58514" checksum="72C4A414AC03B06A" modified="2014-10-01" version="1">MKLQVTLDKMRRFSLLIAFLFCTDRVARLEAAVVHNLSSIFNNQPSKNWVILVAGTNTWESYRHQANVYHAYHIVRANKIPAENIITIAYDDIANNPKNPFKGKVFHDYEHKDVYKGVVIDYRGKDVKPYIFTMVMTGDERLEKEGKKVLKSGPDDNVFIYYTGHGFRNYITFPEGYLTAAQLNDILLHLYKKKKYNKLVFYMDACYSGSMVLDLIPPNVGIYVTTSANEKEESYGVFCTDKQIDVCLATEYSYAWITDSEHSDLKKRTLEQQYQEVKKRTTLSHVMKYGEMVSQKNTRGEIQFYHQSIMKMSAFVDMSLSDLKKRTLEQQYQEVKKRTTLSHVMKYGEMAMGSLPVEKFQGHYDLQMHQNDEAKKVKVVDRKLSSRMHLFSISRRLMGAATEEEHEAAWRNLHRALQLLHVVKDTVADIVRDVMIHHKPMVKRLPRWDELMCFKAVFDQFQTHCFTIQHVPGFAQLSVQLMELCEAGYEVEATIKSLHRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFH4</accession>
    <name>A0A074ZFH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170189.1">
        <property type="nucleotide sequence ID" value="XM_009171925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFH4"/>
    <dbReference type="GeneID" id="20320791"/>
    <dbReference type="KEGG" id="ovi:T265_06612"/>
    <dbReference type="CTD" id="20320791"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14477" checksum="945E4A6F99878D98" modified="2014-10-01" version="1">MGVFLENSLIWVQVEHKVDGSSGTARPSDEPQEGRNRSLIWVQVEHNVDGSSGTARPSDEPQEGRNRSWAVEQLSATFVRAKTNVKITDDKVRWMDTQVLTCSASESGSFEAQFQNGPWISPGISTGLPSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFL0</accession>
    <name>A0A074ZFL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596810">
        <property type="protein sequence ID" value="KER24427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171824.1">
        <property type="nucleotide sequence ID" value="XM_009173560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFL0"/>
    <dbReference type="GeneID" id="20322082"/>
    <dbReference type="KEGG" id="ovi:T265_07903"/>
    <dbReference type="CTD" id="20322082"/>
    <dbReference type="OrthoDB" id="10672469at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="26825" checksum="3030604CBA057281" modified="2014-10-01" version="1">MTREEFFKRVFAKVGNFIIRRAHLEGHVCKQKGEYISDGSIYSGHGESSTSRPSPRVYKQSRQKIKHSIPTKLAKLMNDDSDNIGISQPPLLCRHSPPRSSVADCLKSRRHTDRDYVKIRLEKEILKGSLFYESSDDESSVSGDCERVFSSSQQVVRFVAKVNPEESECAQPSTNLSRKDSASKPRTAAHEINGMHVHHCATAPGITVPKNEIHKFSWNPMEYGKFTKAFQMSAADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFN5</accession>
    <name>A0A074ZFN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">T265_07880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596809">
        <property type="protein sequence ID" value="KER24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171794.1">
        <property type="nucleotide sequence ID" value="XM_009173530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFN5"/>
    <dbReference type="STRING" id="6198.A0A074ZFN5"/>
    <dbReference type="GeneID" id="20322059"/>
    <dbReference type="KEGG" id="ovi:T265_07880"/>
    <dbReference type="CTD" id="20322059"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="17049" checksum="70F723B5C84D7652" modified="2014-10-01" version="1">MVSQFLSVYAHSQLPITLLKAAINLPMLVELKSGETYNGHLAACDDWMNIHLKEVICTSRDGDRFWRMPECYIRGSIIKYLRIPDDVIDKVKEDIQLAKARSRSQSADGARGGFHRNKGKGRGAPGTGGPRGGGRGGSVGRGGAPGGGGGGGPGRGSFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG38</accession>
    <name>A0A074ZG38_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">LIM domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14069</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170131.1">
        <property type="nucleotide sequence ID" value="XM_009171867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG38"/>
    <dbReference type="STRING" id="6198.A0A074ZG38"/>
    <dbReference type="GeneID" id="20328235"/>
    <dbReference type="KEGG" id="ovi:T265_14069"/>
    <dbReference type="CTD" id="20328235"/>
    <dbReference type="OrthoDB" id="9990008at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF168">
        <property type="entry name" value="PROTEIN APTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="433"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="435"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71217" checksum="2EBF98C37EB8213C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGQ5</accession>
    <name>A0A074ZGQ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169875.1">
        <property type="nucleotide sequence ID" value="XM_009171611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGQ5"/>
    <dbReference type="STRING" id="6198.A0A074ZGQ5"/>
    <dbReference type="GeneID" id="20320552"/>
    <dbReference type="KEGG" id="ovi:T265_06370"/>
    <dbReference type="CTD" id="20320552"/>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000004">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF2">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="4">
        <location>
            <begin position="64"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="26623" checksum="81BB953AEF62F5C7" modified="2014-10-01" version="1">MGNNACAAMRELVGGPSGPEKGTNLVSSKDLLVFATDPESSSTQAEMIFGNPGGPRFRGSPRLKGTTLAIIKPHAVSDGLIGSVWTAIRERGFCISAARLYRLSKADAAEFLEVYKGVAHEYPEMLDQLASGPCVALEIATMEEGVDVQKTFREFVGPVDPEIAKFLRPQTLRAKFGIDKIRNAVHCTDLPEDAELENLRVWGRKWRRVKGASLGLAGNLTNQGMPSFGPCPARDIRPNDVMFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH42</accession>
    <name>A0A074ZH42_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169639.1">
        <property type="nucleotide sequence ID" value="XM_009171375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH42"/>
    <dbReference type="GeneID" id="20320356"/>
    <dbReference type="KEGG" id="ovi:T265_06174"/>
    <dbReference type="CTD" id="20320356"/>
    <dbReference type="OrthoDB" id="6274314at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="442" mass="51621" checksum="B48FF9F0968FBBA2" modified="2014-10-01" version="1">MWRLVDSIHWRDHLVDSCASNRGTMGHDDPTDAKRVLVRSFLHYVELMKKDYDCMGQARTLQMLNELHARAKDEALIMLDSEIAADDPAVVEQFRNRLMQNIELQLDKRRNELEDLIKWKAVPRNGNNDGGIDERLKKELDQQKQHYELLMNNTLDEQKEHHARLMKVQLDEQKLFYETLLETKATEMNKLKQELNRISSEKEELQRRLEENTSEATEMADFLSRFGGQENGFDSIQQKQCVVMLRQLLETSNARTTKEMQNELDNQKAVYEEMLKSKDRELEELRQDRERLSGKVEELQCQLECSCNEAVATLEHRAAELGQLREERDRLSNEVNSLRQQVMTGTKEATEQAARHKAELEDLTGSWQQMLRTKEELLEFKTAELTRNPNLFLDRKDEEIRQLKTEILLKDRSIEDLKTLLHTVDNSNEIRKASLQVGGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP5</accession>
    <name>A0A074ZHP5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169430.1">
        <property type="nucleotide sequence ID" value="XM_009171166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP5"/>
    <dbReference type="GeneID" id="20320189"/>
    <dbReference type="KEGG" id="ovi:T265_06007"/>
    <dbReference type="CTD" id="20320189"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15330" checksum="C7CDAE8F6DDC97F6" modified="2014-10-01" version="1">MWMESVQEYTMLRGGQPLTWQRSMKKMTKRLGAVGATRLPEWIPRDPHCAWLDTLHDMAANRWLSNKSWLYGSEASVLNTDVMLSMMMTKVTMQEFLLPGSMNKSDADVLVRKNHTRNYHTSVGLTVYHGNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHQ6</accession>
    <name>A0A074ZHQ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169443.1">
        <property type="nucleotide sequence ID" value="XM_009171179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHQ6"/>
    <dbReference type="GeneID" id="20320202"/>
    <dbReference type="KEGG" id="ovi:T265_06020"/>
    <dbReference type="CTD" id="20320202"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23572" checksum="5873074E5888FECC" modified="2014-10-01" version="1">MSTELLINFQSSLDFGRNGMYRMLSQRLTAQDGVYGWRPCKIWLPIDVVIFNLVCLNERLKVWAPQNDCTQWLGRELTDRTVRSSNSVQASRLVLSRLGQCGSASALVLSLGGMVARHRKGGINEGANLLTGQSVVRTQSKHLDWFCLDLGNAAVPRPSSFLWVAWETLSRTSWWVKSPRMRRMKFTHDLLRSRTDVSRRWIFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHY6</accession>
    <name>A0A074ZHY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596874">
        <property type="protein sequence ID" value="KER22905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173361.1">
        <property type="nucleotide sequence ID" value="XM_009175097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHY6"/>
    <dbReference type="STRING" id="6198.A0A074ZHY6"/>
    <dbReference type="GeneID" id="20323288"/>
    <dbReference type="KEGG" id="ovi:T265_09109"/>
    <dbReference type="CTD" id="20323288"/>
    <dbReference type="OrthoDB" id="409048at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15136" checksum="0A03BE9E4B0E11C5" modified="2014-10-01" version="1">MGRSSKKTISPGDCGNYSGISLTPVVTRLLASIVLRRLTVAREILTREQQAGFRPGPALRTDDSVCHASALRTTYARHMAPTSPGIPESIFKPRHPVYLAAFHVCTLKQAGQQAALALTLDSLGIDVCCASETRIQNTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZII7</accession>
    <name>A0A074ZII7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170631.1">
        <property type="nucleotide sequence ID" value="XM_009172367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZII7"/>
    <dbReference type="GeneID" id="20321140"/>
    <dbReference type="KEGG" id="ovi:T265_06961"/>
    <dbReference type="CTD" id="20321140"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="13994" checksum="34F129788D7A065F" modified="2014-10-01" version="1">MSLCLMLQTITPRLPYQNLKTPNSLFLLNLIESKQSKKSSSLIAISQLQVSESGSANNWLIVTTQATYRNVEAIACRQQIMAADGCWMPDGATVPEFPVKPGGVSDGSNTLKADQDQMLSMVNESLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIK6</accession>
    <name>A0A074ZIK6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169102.1">
        <property type="nucleotide sequence ID" value="XM_009170838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIK6"/>
    <dbReference type="GeneID" id="20319940"/>
    <dbReference type="KEGG" id="ovi:T265_05758"/>
    <dbReference type="CTD" id="20319940"/>
    <dbReference type="OrthoDB" id="5783753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029160">
        <property type="entry name" value="UQCC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15013">
        <property type="entry name" value="CCSMST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="22078" checksum="290EDCB85C192EA6" modified="2014-10-01" version="1">MAVYLSQFLVIESGAAGTDVGLLSCRTIDRLADLYSETGEKQCLTRRNGGDRSEIQRLLYVRMEISPAKLMVSRLAVIISSRLRSLPDEVAACYALHIPNRRLLFQAIKSTPRTRFSQAADKSAVLPDGQLRYSTNKKWHAAMNFVPKPRDIPSYQYPVIIASAGVCLIYFCLLREENDLDRILAGEITVEDILKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJM0</accession>
    <name>A0A074ZJM0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596760">
        <property type="protein sequence ID" value="KER25987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170269.1">
        <property type="nucleotide sequence ID" value="XM_009172005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJM0"/>
    <dbReference type="GeneID" id="20320859"/>
    <dbReference type="KEGG" id="ovi:T265_06680"/>
    <dbReference type="CTD" id="20320859"/>
    <dbReference type="OrthoDB" id="410381at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28693" checksum="CE25F10C6AA32B17" modified="2014-10-01" version="1">MLVAHFQLCSGHELSLTTTNSQHKRSDCVIWRPPTVNQPWTQFDHVSISDRWPVNKKHANPSSSVNYHSPAVSVRANPTTLEDVSRVRKLSVVIVIKDSNISVATGASLTAALHKVMNDSSSKFLRVAPQEKPTWPDRDACRFWWISSNLSKSLCGTSEDEPASTDVIKRRTITGELELEPWNIRTTLDRVDSDSHERQITLVAKRLERWCVDIAAWNVTRLVKHEKLETEAGQSTVDGTRVCILQCPKTFLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJM1</accession>
    <name>A0A074ZJM1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169119.1">
        <property type="nucleotide sequence ID" value="XM_009170855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJM1"/>
    <dbReference type="STRING" id="6198.A0A074ZJM1"/>
    <dbReference type="GeneID" id="20319957"/>
    <dbReference type="KEGG" id="ovi:T265_05775"/>
    <dbReference type="CTD" id="20319957"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="521"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="691" mass="76453" checksum="8371B16669D2E8FF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK69</accession>
    <name>A0A074ZK69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596837">
        <property type="protein sequence ID" value="KER23750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172504.1">
        <property type="nucleotide sequence ID" value="XM_009174240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK69"/>
    <dbReference type="GeneID" id="20322618"/>
    <dbReference type="KEGG" id="ovi:T265_08439"/>
    <dbReference type="CTD" id="20322618"/>
    <dbReference type="OrthoDB" id="10419538at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8636" checksum="556BAE2FDEEED3B0" modified="2014-10-01" version="1">MIQLARYSKHHNERFSWVPVAKILDSKTSFPSKYLCNVLLIRLLKIRRQPTTGFTLPLGAHQVGPVPEFPSTLCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKC5</accession>
    <name>A0A074ZKC5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168737.1">
        <property type="nucleotide sequence ID" value="XM_009170473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKC5"/>
    <dbReference type="GeneID" id="20319644"/>
    <dbReference type="KEGG" id="ovi:T265_05462"/>
    <dbReference type="CTD" id="20319644"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="14697" checksum="64CAE86F52F80170" modified="2014-10-01" version="1">MKETTHKVAENSWTAHDRFRPSWNSSGRRDLSAICQPCVLLEPKVDRFGQILAFIYELAECAAPGYLMFQSLRYSRYRDTYICTTLLIRLLRRLSRSFQQPYEYESLVYNVNQLNMLRAGRLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKE2</accession>
    <name>A0A074ZKE2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172437.1">
        <property type="nucleotide sequence ID" value="XM_009174173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKE2"/>
    <dbReference type="STRING" id="6198.A0A074ZKE2"/>
    <dbReference type="GeneID" id="20328724"/>
    <dbReference type="KEGG" id="ovi:T265_14558"/>
    <dbReference type="CTD" id="20328724"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF10">
        <property type="entry name" value="PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="32673" checksum="4DED636CF8D01CF0" modified="2014-10-01" version="1">MYSFDRCPDSALDTYHSISNAYSELLSDLRLPYHKVLACAGPIGGHLSHEYHIPSSVGEDILCICQKCGKGYNAELEDGAERIGCTDSSCSHEFQKIRGSEVGHCFLLGRRYSSCFDANYHGLDGKITLEMGCYGLGLTRLVAVGVEYLSAAAFPDLPNEQISEIRWPQGLAPYRGCIVLQKETAKDAMNAKELNSIFDILADASYDLRFPGDILVDDRPGLSLGRKLVDIRRLGIPWIAILKSSAGSLGPFELIDLHRGRSHAAMVHEIRSAFEQPTLFNSSALPEWDMSSRKAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKT9</accession>
    <name>A0A074ZKT9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169890.1">
        <property type="nucleotide sequence ID" value="XM_009171626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKT9"/>
    <dbReference type="STRING" id="6198.A0A074ZKT9"/>
    <dbReference type="GeneID" id="20328181"/>
    <dbReference type="KEGG" id="ovi:T265_14014"/>
    <dbReference type="CTD" id="20328181"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="33341" checksum="17804D1D61DADEFF" modified="2014-10-01" version="1" fragment="single">MDALFVIQRKVEVNGPSVGENKMPSGVTAGCIDGLSGAQESVAITELAWLAAVHTWRGWMAQSKFAVLRLSRLPQYFGEKEVLEYLSQFGKVDAVYMPKSKKTLRHQGYAFVKISKELAPIVVSTLDSVLNFNKLMKYKPHRGDYQQVSSQIRILPPGNSAQYQPLHIPPQQPLDHQSLIPQTKGRTAPTIKNRPSVTLSMLSCHTTWRKHECRDTAKLPKARRGKSRGGGRFRTTDRLIPQTKGRTAPTIKNRPSVTLSMLSCHTTWRKHECRDTAKLPKARRGKSRGGGRFRTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKV1</accession>
    <name>A0A074ZKV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169828.1">
        <property type="nucleotide sequence ID" value="XM_009171564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKV1"/>
    <dbReference type="GeneID" id="20320513"/>
    <dbReference type="KEGG" id="ovi:T265_06331"/>
    <dbReference type="CTD" id="20320513"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10106" checksum="327175123BA160BD" modified="2014-10-01" version="1">MLGTVWLAKQDKSSDKGNVNEWLTFFFNKCFRERVLATGFFPEFDPCVLWLFNVPVATRARSDFLKPATGDNGLAVPSVWWSGIGSSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLM9</accession>
    <name>A0A074ZLM9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168292.1">
        <property type="nucleotide sequence ID" value="XM_009170028.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLM9"/>
    <dbReference type="GeneID" id="20319293"/>
    <dbReference type="KEGG" id="ovi:T265_05111"/>
    <dbReference type="CTD" id="20319293"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="802"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2606"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2612"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2630"/>
            <end position="2656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2947" mass="325402" checksum="B28AFE92CF5F40D2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU3</accession>
    <name>A0A074ZLU3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171911.1">
        <property type="nucleotide sequence ID" value="XM_009173647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU3"/>
    <dbReference type="GeneID" id="20322149"/>
    <dbReference type="KEGG" id="ovi:T265_07970"/>
    <dbReference type="CTD" id="20322149"/>
    <dbReference type="OrthoDB" id="6255108at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="631" mass="66561" checksum="CD43CB1216768E3F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLX6</accession>
    <name>A0A074ZLX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169473.1">
        <property type="nucleotide sequence ID" value="XM_009171209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLX6"/>
    <dbReference type="GeneID" id="20320221"/>
    <dbReference type="KEGG" id="ovi:T265_06039"/>
    <dbReference type="CTD" id="20320221"/>
    <dbReference type="OrthoDB" id="6266479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="486" mass="54710" checksum="8110C012996223A7" modified="2014-10-01" version="1">MKFCLVHDGPRWLKWSARKFTDRKVRGSNSTSTSRLPLSRLGQPGSIPALVLPPGCMEGRHRKGVTAEPLLYYLVHNTGQLKSRLVLETKHLGWIKFWVQRRSQTSQSKLPTICSGYLLSSTARTTIELFDIPNFYSNSTSAYSTSCSWVRFTIKIQKPRYTTKTTGVFTNQLSSAHTARIEKKSFSCSTLLVLNCHDTRSKLDGWDTARLPEARQGKPGGRGRVQTTDFLVNKYVLLPLSHLARCDAASGLFLFLVFRACLTRSDFTGSDTSHGFVSSLIVSEMQPHGHWYSTTVERCGSQTGRSHHGPCKYITVRTKGHSEETVDIEQAFSNTTQWDAEVRKLSHHDKAQSVCDASDDPYRFSGSQPVTFNFAATRPKNEHHPPWLVSGSRRKITSSVVQHLADAGHNVILSQSFRIVYETPANQPRLVQQRTIAVAEAITIRHDPLSLGIEQRFFRINLAGAEDQDPELPHRTRTYQLHICKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMH9</accession>
    <name>A0A074ZMH9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167682.1">
        <property type="nucleotide sequence ID" value="XM_009169418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMH9"/>
    <dbReference type="GeneID" id="20318818"/>
    <dbReference type="KEGG" id="ovi:T265_04636"/>
    <dbReference type="CTD" id="20318818"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17416" checksum="81E970905B0C1758" modified="2014-10-01" version="1">MYQNKQTHQQVVEREFTYRKVRGSNPTSASRLPLSSLRQSGSNLRVQPAANTNLQYTSLMVFLPVHLVTLLSSATNWILYTIKWLSKELDSEYYLVHLTTTQLELRLNPYRIVSFSCNALPVPSCNATRRKQEGWDTGRTPNLGKGSRGAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMM1</accession>
    <name>A0A074ZMM1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167927.1">
        <property type="nucleotide sequence ID" value="XM_009169663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMM1"/>
    <dbReference type="GeneID" id="20327774"/>
    <dbReference type="KEGG" id="ovi:T265_13607"/>
    <dbReference type="CTD" id="20327774"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="423" mass="47337" checksum="5DE7D636F14A43F0" modified="2014-10-01" version="1">MPPEESKRAGILPGCASLDRRSREAEVGFEPRTLRSVDSRSNHLGHLAPIRPSLFVTTLVDRLFFALHELLSICLSDLDLFRQIHNNFRSNDNRSFSPNKADRCSSLNPSIFTAVAWIYVATNPPLRTTTLPSNALTMSSRLAMKRLQSNCPAQRTNQRPSTLPELPKFSSIEDLLASSACLQRTSQFLPLQRIARDISVSVASFASSEQLFDHIRFSVERSAVTPLRCQAATSPKGSTRAETLPGCPSLDIISRGAWVEYESRAFWSAGIHADPTIPHVFRRCYGREAWPARGWPKIRDACRSGIKRRSDWSTIWTQQPIMTQYWPNAGCQWSSRTRQKFQKVIAAYAIYTKRCTTVPDFVLGIRPTDAPILPTGPSDMSLEMLLDTLISAPSQEVNQLLRQRPSPSTNYNRDAGQTGSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPK4</accession>
    <name>A0A074ZPK4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione gamma-glutamylcysteinyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="2.3.2.15" evidence="1"/>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166919.1">
        <property type="nucleotide sequence ID" value="XM_009168655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPK4"/>
    <dbReference type="STRING" id="6198.A0A074ZPK4"/>
    <dbReference type="GeneID" id="20327553"/>
    <dbReference type="KEGG" id="ovi:T265_13386"/>
    <dbReference type="CTD" id="20327553"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016756">
        <property type="term" value="F:glutathione gamma-glutamylcysteinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010273">
        <property type="term" value="P:detoxification of copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.30:FF:000001">
        <property type="entry name" value="Glutathione gamma-glutamylcysteinyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.30">
        <property type="entry name" value="Phytochelatin synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040409">
        <property type="entry name" value="PCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007719">
        <property type="entry name" value="PCS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038156">
        <property type="entry name" value="PCS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33447:SF2">
        <property type="entry name" value="GLUTATHIONE GAMMA-GLUTAMYLCYSTEINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05023">
        <property type="entry name" value="Phytochelatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51443">
        <property type="entry name" value="PCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0104">Cadmium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C83" evidence="5">
        <location>
            <begin position="66"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="546" mass="61264" checksum="BAFA3919B8C0B6DD" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPQ3</accession>
    <name>A0A074ZPQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596714">
        <property type="protein sequence ID" value="KER27787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168458.1">
        <property type="nucleotide sequence ID" value="XM_009170194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPQ3"/>
    <dbReference type="STRING" id="6198.A0A074ZPQ3"/>
    <dbReference type="GeneID" id="20327888"/>
    <dbReference type="KEGG" id="ovi:T265_13721"/>
    <dbReference type="CTD" id="20327888"/>
    <dbReference type="OrthoDB" id="6259957at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24265" checksum="FFF72BB4200D72C4" modified="2014-10-01" version="1" fragment="single">MTELSTQHPVIDISQQWSLACSLRAFCSARNNLIDWNLFIKETTHKVAENSSKPMTRFRPSSSGSSGRRSSRVSVKLMFNLNPNWTVFEKYTHLQTNLVFTRDSTKSLFTFGGQTYQQLKGTAMGSPISGLIAEAVMQRIERAVLPIINPKLGIRYVDDTFVVMKRNSVHDARELLNTTFDDIKFTIELERNNRLPFLDVLVNRKVDGTLETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQQ6</accession>
    <name>A0A074ZQQ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166456.1">
        <property type="nucleotide sequence ID" value="XM_009168192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQQ6"/>
    <dbReference type="GeneID" id="20317837"/>
    <dbReference type="KEGG" id="ovi:T265_03650"/>
    <dbReference type="CTD" id="20317837"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="27277" checksum="B626E344FA1439DC" modified="2014-10-01" version="1">MSLPLGAKRRKDTVSCLPSGRTMWAYCGLQETSSTSSTRGSYLETRSLRFKRIGPGTVSQYHTLPIPTGAAVNFHWKLQTIHQSIMRRFKRRSQSRIKRIQTQNDITKLSFIKPVRIEIRQQSSSDGGSIPVESVETRVLNLWSTQNGTKFSRHLEVKGWSPLCLRHSELGVENNAFFGKRRLGIRNTCLNQHNFCCFAHSSMGVPITQPKTRFLTVSLRNRRHQPTQGAVLRQRLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQS9</accession>
    <name>A0A074ZQS9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166484.1">
        <property type="nucleotide sequence ID" value="XM_009168220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20317865"/>
    <dbReference type="KEGG" id="ovi:T265_03678"/>
    <dbReference type="CTD" id="20317865"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2945" mass="291941" checksum="2A949DECBB47857D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR06</accession>
    <name>A0A074ZR06_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168049.1">
        <property type="nucleotide sequence ID" value="XM_009169785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR06"/>
    <dbReference type="STRING" id="6198.A0A074ZR06"/>
    <dbReference type="GeneID" id="20327797"/>
    <dbReference type="KEGG" id="ovi:T265_13630"/>
    <dbReference type="CTD" id="20327797"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="31027" checksum="82406DF23B0FC80E" modified="2014-10-01" version="1">MSPSKNRVPFPIQMRLDFGQKDLGATRCVDCGMVYNKGDKEDDKLHKIHHRKIVPDVAKLPRGRSQRILEEYFDGSRIVELVLNSTVGTSYFSRIARLMARDLGCDHSQGEGDFITHGETCCTSVTKIPKDWRVFACVQDVSQHVIGCAVVQELTPTLIKSKAYKLRVLPGGISDLLTWTVQAKDVHGSLLPNNNQNTAPPASDNPTSLGPVLCGVRRLWVNRQHRRKGVATKLLDCVLRHLVYAHPLTRKHIAFSDLTADGASFAAKFTGHEKFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRU2</accession>
    <name>A0A074ZRU2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170211.1">
        <property type="nucleotide sequence ID" value="XM_009171947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRU2"/>
    <dbReference type="STRING" id="6198.A0A074ZRU2"/>
    <dbReference type="GeneID" id="20320813"/>
    <dbReference type="KEGG" id="ovi:T265_06634"/>
    <dbReference type="CTD" id="20320813"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="411" mass="44276" checksum="99EE9BA3A2BED1F6" modified="2014-10-01" version="1">MISTSSQLRLPIGIEGISCLTYLQEDEAKQLFALGTTDGRVRIYRSLNGQFECTYQKRWHKSIRCLSLLPSTSHLVSASSQSGLKVHDVESGKRIWAQLHAHKKSPISSLLSTSPVVFVTGDEDAIVQVWDIRKPGAPCHFLRIQNEEQEEEDLFGAVNDMACGDSQNLILGALDNGSLAALNLRKARVEVLSDTLGYSARTVAVIKNNKVAVVGTEDGAICLFNWDEFELCADRFSPFAQKTSKPAAVGSVGVGPSISPSVEKVVKVTEDMIAVATDDGKISAVMIRPNEVLGTIGRHPGSEGDHGADCLNLAVSPHKHLASVCPESSIAQFFSLSEWINRSESLLSNPSGPKKKRRKVASNAMSPDRAEYLSGLLPEKSENGGSESASELESTENSGDDGEDDTDSDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRX3</accession>
    <name>A0A074ZRX3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166352.1">
        <property type="nucleotide sequence ID" value="XM_009168088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRX3"/>
    <dbReference type="STRING" id="6198.A0A074ZRX3"/>
    <dbReference type="GeneID" id="20317756"/>
    <dbReference type="KEGG" id="ovi:T265_03569"/>
    <dbReference type="CTD" id="20317756"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="391" mass="42924" checksum="E529B12B4035406C" modified="2014-10-01" version="1">MLRVRSLLTGVCRSLSSENMTVDLPPSQLRLPRPSKESSFKSVKNTFSSLKQLIENGTWTDIRSLVALIHQKAIDYTSTGVNATPNLHVCLRVLKIAREEALKVLRGSNAEFEENSTNRLFASGDTAYESVVKSDVLEAILGALDEFIVDINACYENISDLSLDLIHSDELILTHGSSQLAYRFLKRAAEKKRMYKVIVCEGYPDNLGHKFAEDLSKEGINVILVPDSHVFGLMSRVNKVIIGCNSVYPDGTMDAPTGTYSVLLAAKHFSIPTYVCLPQYKLSPVPMKASANTPPPYTVLPTKDPSNASPDWIDSPAKILPPDDPIVSSNNLVNLPPANGPVVWVPRWEHIPAGLISLFLTNLGSHAPSYLYALGQELFHPSDIQAIVSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRX6</accession>
    <name>A0A074ZRX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170147.1">
        <property type="nucleotide sequence ID" value="XM_009171883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRX6"/>
    <dbReference type="GeneID" id="20320759"/>
    <dbReference type="KEGG" id="ovi:T265_06580"/>
    <dbReference type="CTD" id="20320759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="20942" checksum="B3FE23887A8AECCA" modified="2014-10-01" version="1">MPSSKVTWASANGDTGQRSNQWNHPTEQLIATKGHPSRAARCDKDHNQLEPVKNCRAGFPLGWLHRSTKPEQSQGRDLGRLAEESQCSSRSTCDQEIHSKAARGPYVVTAPRIRQPMHQNDTLMIITPIRFAWIAWIKDYGGERVHVTKIEIAPNLIPTRNWKTTDGVEWKQSDMIHVIQIVECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS63</accession>
    <name>A0A074ZS63_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_06528</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170075.1">
        <property type="nucleotide sequence ID" value="XM_009171811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS63"/>
    <dbReference type="STRING" id="6198.A0A074ZS63"/>
    <dbReference type="GeneID" id="20320707"/>
    <dbReference type="KEGG" id="ovi:T265_06528"/>
    <dbReference type="CTD" id="20320707"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="47"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="348"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="14">
        <location>
            <begin position="464"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="610" mass="70399" checksum="E04C538C438B11B4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSZ8</accession>
    <name>A0A074ZSZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601897">
        <property type="protein sequence ID" value="KER18394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177859.1">
        <property type="nucleotide sequence ID" value="XM_009179595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZSZ8"/>
    <dbReference type="GeneID" id="20330253"/>
    <dbReference type="KEGG" id="ovi:T265_16088"/>
    <dbReference type="CTD" id="20330253"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="7606" checksum="2431AD373D11EC32" modified="2014-10-01" version="1" fragment="single">MSALVDCPELQLPDDDDSDTEDEYLDSSNLLFQSEAPVDIISAGIDVQPTDVVKQILAEAGLSVGITDPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUF0</accession>
    <name>A0A074ZUF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165499.1">
        <property type="nucleotide sequence ID" value="XM_009167235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUF0"/>
    <dbReference type="GeneID" id="20317070"/>
    <dbReference type="KEGG" id="ovi:T265_02882"/>
    <dbReference type="CTD" id="20317070"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="25267" checksum="7D19BFC879D600D2" modified="2014-10-01" version="1">MGTESSLGSNCRALNKTPTSKTIRATAKHELPLPFIPCLLQTTPEDCMQSSGAPPDWDALTQIGQLLCSRSSHRTNQSPLKRGYVRRLRREKSDASSIVVVTSSHRMPDFQPCQGTSTTYRKLNLVRLFEYYSRIFIVTQFGHCRGYLAAHAALGLRAGRFFIPEKSMSSAEYQASINSRSFCSCLGWYVDTRSVEFTSVLDRIKTTGIHTQAEDESASQRAETGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUT5</accession>
    <name>A0A074ZUT5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165046.1">
        <property type="nucleotide sequence ID" value="XM_009166782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUT5"/>
    <dbReference type="STRING" id="6198.A0A074ZUT5"/>
    <dbReference type="GeneID" id="20316707"/>
    <dbReference type="KEGG" id="ovi:T265_02519"/>
    <dbReference type="CTD" id="20316707"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="98"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29191" checksum="9640E9E183BD0B8B" modified="2014-10-01" version="1">MDYGQYPPVPPSSEHFQPNYFSPGDMQFSQFSYTSAPGAASSQDYPTAFPGDYFTPGPANKHVEDVEDYENEPPLLEELGINFSHITGKTFAVLAPYKESSQEVLEDADLAGPLVFCLIFGCTLLLAGKVHFNYIYGLGVFGCLGIYLLLTMMTPNGVTPTRVASTLGYCLLPMCLLSSLGILMSLTNLLGIVATVAVVLWCAISASKLFVRALDMQHQRILIAYPCALVYSVFALLRVNLEPFSGVTYPKPTGYSIGGWEVKTSHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV19</accession>
    <name>A0A074ZV19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169074.1">
        <property type="nucleotide sequence ID" value="XM_009170810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV19"/>
    <dbReference type="GeneID" id="20319919"/>
    <dbReference type="KEGG" id="ovi:T265_05737"/>
    <dbReference type="CTD" id="20319919"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12377" checksum="FC6376A52A9E94F5" modified="2014-10-01" version="1">MSQPTQLLVLDTFFNGSTRYTHRPTLTKLHSTDECANLRLTETRGLRLPDEPQEGRNRSWAVDKFSATLCVVHYKDIHVSHWIQDSVLPNIRLTETRGLHLPGEPQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW56</accession>
    <name>A0A074ZW56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168675.1">
        <property type="nucleotide sequence ID" value="XM_009170411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW56"/>
    <dbReference type="GeneID" id="20319595"/>
    <dbReference type="KEGG" id="ovi:T265_05413"/>
    <dbReference type="CTD" id="20319595"/>
    <dbReference type="OrthoDB" id="10056483at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="318" mass="35610" checksum="A68FB08701097A39" modified="2014-10-01" version="1">MTASAVPCFRLPTLVYAARNATQLMAPRDGRCPIDQPGTRDPVSVAGTPPGITQRLVEAHEPSLHGLFVTAQVKYQAQLSTSNNQQPINPPRTDTSRIRRPNLAASSERRRLTDGNKTDPGNLGKRLDPRRYRTAVVILAPESRIVHPYVTQRDSANALFLHRVKGPEDITGIISERNFCVNMPTKLSTHDARETQPSLDVSSELRKWLRALNQWKIESISRCLTPFLLGVSSPPRRPNDKLFILILTCLLTHYLIITFTLFEQGLANRFFTIDPAKHVSRRSSSLVLAPTNLLPRAEVIKSSDSPLFRLCLSDEHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWC2</accession>
    <name>A0A074ZWC2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164534.1">
        <property type="nucleotide sequence ID" value="XM_009166270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWC2"/>
    <dbReference type="GeneID" id="20316299"/>
    <dbReference type="KEGG" id="ovi:T265_02111"/>
    <dbReference type="CTD" id="20316299"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7874" checksum="E2089234B0D5C61A" modified="2014-10-01" version="1">MSRQKSRGDLCTTHSVEEYHRYGLPPDLDGVSRASFHVSNARSSTGFKTLQSDLSRLDAVAVSHMESTPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX00</accession>
    <name>A0A074ZX00_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168388.1">
        <property type="nucleotide sequence ID" value="XM_009170124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX00"/>
    <dbReference type="STRING" id="6198.A0A074ZX00"/>
    <dbReference type="GeneID" id="20327871"/>
    <dbReference type="KEGG" id="ovi:T265_13704"/>
    <dbReference type="CTD" id="20327871"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="253" mass="28799" checksum="B182CCFA677706ED" modified="2014-10-01" version="1" fragment="single">RTRVIHPSAERVSVGSKLDTGADRPSLSGFYSARQISNGEIASLPERLGPLLFVYHRLKKDIMGAILPTKSLPKGEVKKLVQKTHFSEHQIKKWYKEFIKDCPSGLLNRATFLSMYTQFFPDGKARPFYEHLFRTFDQDGSGNIDFTEFLTAISITQSGDPEEKLDLAFQLYDIDRNGTIEESEMTQIITAIHLMVGEVDTRDNNPGERTRAIFQKMDANSDKLLTKEEFIKGCLSDEHLYRLLAQSEDKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX46</accession>
    <name>A0A074ZX46_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168343.1">
        <property type="nucleotide sequence ID" value="XM_009170079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX46"/>
    <dbReference type="STRING" id="6198.A0A074ZX46"/>
    <dbReference type="GeneID" id="20327858"/>
    <dbReference type="KEGG" id="ovi:T265_13691"/>
    <dbReference type="CTD" id="20327858"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER27930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11330" checksum="0CBA4DE333BCDFA0" modified="2014-10-01" version="1" fragment="single">MLLFAVYHGIIIIVLVNMLIAMMSHSFESIQEECDVEWKFARMQLWLNYIDNGSTLPAPFNVLPTPHRLTNALRFIRNFFNDDSRFFNGNTRSTAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXG6</accession>
    <name>A0A074ZXG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164112.1">
        <property type="nucleotide sequence ID" value="XM_009165848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXG6"/>
    <dbReference type="STRING" id="6198.A0A074ZXG6"/>
    <dbReference type="GeneID" id="20315946"/>
    <dbReference type="KEGG" id="ovi:T265_01758"/>
    <dbReference type="CTD" id="20315946"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="888"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120918" checksum="3AE92EEEC87A8D3B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYW8</accession>
    <name>A0A074ZYW8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164023.1">
        <property type="nucleotide sequence ID" value="XM_009165759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYW8"/>
    <dbReference type="STRING" id="6198.A0A074ZYW8"/>
    <dbReference type="GeneID" id="20315881"/>
    <dbReference type="KEGG" id="ovi:T265_01693"/>
    <dbReference type="CTD" id="20315881"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="354"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="682"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="851"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="939"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126242" checksum="079ED1D8EDD917A8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ66</accession>
    <name>A0A074ZZ66_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="6"/>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163467.1">
        <property type="nucleotide sequence ID" value="XM_009165203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ66"/>
    <dbReference type="STRING" id="6198.A0A074ZZ66"/>
    <dbReference type="GeneID" id="20315406"/>
    <dbReference type="KEGG" id="ovi:T265_01218"/>
    <dbReference type="CTD" id="20315406"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="317" mass="36150" checksum="74084F25CFC1FD3F" modified="2014-10-01" version="1">MSEMVFGVELLKGSYEEMVIFLGAQYDTVDHNEKERIGPAQRDVDSQCIAKKSRSGTGEDQRRGPYAQKKYNSCHCLTVGVSEAFAGSGGDVVLVMLMEKELFRFIGYAGWNMYSACRKTVCLTEAFPPALCFYGYFLNPFSERPRIRTNTVDLDRLRKLPPNSFGNAYVAFLDHYKYSPDERHLVQFVDDPDLAYVMQRYREVHDLVHTLLEQPTDMLGEVVVKWVEGIQTGLPMCLTGGFAGSLRLAPVQTRNYLNTHLDYALRVGFEGRSLMNVYFEEHWEQPLDEFRSSLNIPPPPVRHFGRKRQKASTGVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN9</accession>
    <name>A0A074ZZN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164724.1">
        <property type="nucleotide sequence ID" value="XM_009166460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN9"/>
    <dbReference type="GeneID" id="20316444"/>
    <dbReference type="KEGG" id="ovi:T265_02256"/>
    <dbReference type="CTD" id="20316444"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9086" checksum="7F0845EE93F21316" modified="2014-10-01" version="1">MHFPIFSHSGGFVANFLLGGLGKSYGLIMDAFQEVYQSGSALFMLAGGLIYTLMFCLCNFSILLSETGDLPAVSTAQTILELSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A039</accession>
    <name>A0A075A039_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167320.1">
        <property type="nucleotide sequence ID" value="XM_009169056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A039"/>
    <dbReference type="GeneID" id="20327642"/>
    <dbReference type="KEGG" id="ovi:T265_13475"/>
    <dbReference type="CTD" id="20327642"/>
    <dbReference type="OrthoDB" id="6261007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="26893" checksum="3CA7B81DFA8136A2" modified="2014-10-01" version="1" fragment="single">MTMNSSFFSSEENSQTAYKINAFDGCSPLSSYLDDTRFRNQKSTYESSTKAVKHLKQDNLALKDLGCVNKSLNEGFSEPNNNSTYGKEIRQAYTEFLRCSSPKLQKIRDRLRSVRNEFIKHKSDCEKNKKMFPQEVLLRIKKELQHATDSLFTEPISEDGPHRTPQFLHSSDPSDLSDHAPPNMDLCKCEALCNRIQNSITKTTHILLDLRANMEEYLKQGGSGNSQRLVDDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A255</accession>
    <name>A0A075A255_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174763.1">
        <property type="nucleotide sequence ID" value="XM_009176499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A255"/>
    <dbReference type="GeneID" id="20324367"/>
    <dbReference type="KEGG" id="ovi:T265_10199"/>
    <dbReference type="CTD" id="20324367"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="20723" checksum="7E607E0684D799BA" modified="2014-10-01" version="1">MVPIRDTRNEQEESSPKTIHQGQDGDVWVQHLEPSVCNNNCNFHWFGAGLDRFHCRTIGSQSFRGTTASCVAFESATRRGTCCGQIGADGNNFLSISSRRSARPSESVGRNAMLGAGASQWTGLVMLETRSIVLKAVRIGIVRYDKWTTSLETLNVTKLIFIDRNTLTLTTFLEDPLPLLAKVDVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2E1</accession>
    <name>A0A075A2E1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162345.1">
        <property type="nucleotide sequence ID" value="XM_009164081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2E1"/>
    <dbReference type="GeneID" id="20314524"/>
    <dbReference type="KEGG" id="ovi:T265_00336"/>
    <dbReference type="CTD" id="20314524"/>
    <dbReference type="OrthoDB" id="6259922at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="61813" checksum="1CEB84A6D4F7D8F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2S4</accession>
    <name>A0A075A2S4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166357.1">
        <property type="nucleotide sequence ID" value="XM_009168093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2S4"/>
    <dbReference type="GeneID" id="20317761"/>
    <dbReference type="KEGG" id="ovi:T265_03574"/>
    <dbReference type="CTD" id="20317761"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="182" mass="20808" checksum="D331E000D82BBE50" modified="2014-10-01" version="1">MSGFIKCQLSFAFESDGSPSMLSIRIINAVGLRHSHSRIATHLLSTMGLLGAEHKQQYGSMPTTMNRLWAFNMISLLYECPGPAPQITRRILITDRITRLPSGLLKNKRIVWKSHVTQHAFSRWGVNISQKKTENRVEQCKGDRWDHCDKCVERDDHSRGRDCTAEHILVRLNRKAEVAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A316</accession>
    <name>A0A075A316_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162237.1">
        <property type="nucleotide sequence ID" value="XM_009163973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A316"/>
    <dbReference type="STRING" id="6198.A0A075A316"/>
    <dbReference type="GeneID" id="20314453"/>
    <dbReference type="KEGG" id="ovi:T265_00265"/>
    <dbReference type="CTD" id="20314453"/>
    <dbReference type="OrthoDB" id="6243574at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="464"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="937" mass="107843" checksum="8EE2D170EC4799EC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A326</accession>
    <name>A0A075A326_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.4</ecNumber>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="7">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="7"/>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162469.1">
        <property type="nucleotide sequence ID" value="XM_009164205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A326"/>
    <dbReference type="STRING" id="6198.A0A075A326"/>
    <dbReference type="GeneID" id="20314620"/>
    <dbReference type="KEGG" id="ovi:T265_00432"/>
    <dbReference type="CTD" id="20314620"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="10">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7 8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="34511" checksum="ACC524C0A4E0C6CC" modified="2014-10-01" version="1">MSCPRLLFSPTFFRSIMKTASRNVYADTRKHLMLDQNTKLICQGFTGKQGTFHCQQTLDYGTKLVGGVSPGKGGSKHLGLPVFNTVKEAKEATGATASVIYVPPPFAPAAINEAIDSEIPLIVCITEGIPQHDMIRIKKRLMEQSSSRLIGPNCPGIIKPNVCKIGIMPGHIHTPGKIGIVSRSGTLTYEAVFQTSQEGHGQSLCIGIGGDPFNGTNFIDCLEVFLKDPQTEGILLLGEIGGEAEEKAAAYLKEHNSGPNRKPVAAFIAGLTAPPGRRMGHAGAIISMGKGGAKEKMACLEDAGVCVTASPAQLGATMTKALREAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3F3</accession>
    <name>A0A075A3F3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596930">
        <property type="protein sequence ID" value="KER21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174314.1">
        <property type="nucleotide sequence ID" value="XM_009176050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3F3"/>
    <dbReference type="STRING" id="6198.A0A075A3F3"/>
    <dbReference type="GeneID" id="20324020"/>
    <dbReference type="KEGG" id="ovi:T265_09852"/>
    <dbReference type="CTD" id="20324020"/>
    <dbReference type="OrthoDB" id="6161488at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704488" evidence="2">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="394" mass="45336" checksum="AABF60CB1F05DEB8" modified="2014-10-01" version="1">MVRSRRRSHLVILVKQLSVKQLGCPCCPCPCPSNTCEDYRNQAEVLNTSQIVRANKIQAENKVTFAFDDIAKNIKTSFETTQTIRYKVQIVTTALCGLVQHRPYCIAGSRRCPQLLTDIQQQAVKELRCPRHRTQLLAKLSASECNDHIGFLSNEHQVDYSVEANHHWRQSDGKILTKVNENKRSIGYPSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQIRSDQISSVQFRSDHIRSGRRAGPLALPGMSDPPAGPNRKLRQIDSVQFTPLLILNGSNNGIKGKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3K1</accession>
    <name>A0A075A3K1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174257.1">
        <property type="nucleotide sequence ID" value="XM_009175993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3K1"/>
    <dbReference type="STRING" id="6198.A0A075A3K1"/>
    <dbReference type="GeneID" id="20323978"/>
    <dbReference type="KEGG" id="ovi:T265_09810"/>
    <dbReference type="CTD" id="20323978"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="249"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="455"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="894" mass="99060" checksum="2B3D0325B93BDECA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3N0</accession>
    <name>A0A075A3N0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163393.1">
        <property type="nucleotide sequence ID" value="XM_009165129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3N0"/>
    <dbReference type="STRING" id="6198.A0A075A3N0"/>
    <dbReference type="GeneID" id="20315356"/>
    <dbReference type="KEGG" id="ovi:T265_01168"/>
    <dbReference type="CTD" id="20315356"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="475" mass="54172" checksum="A4772A7E233526DA" modified="2014-10-01" version="1">MLSHLNHHRVPFQQLLCYVMFTHFDFFMGDSREHIYNTLIKVNKQFFSQLSYPVIIGRPNVTLGWQVRTYRSANYWFISPVIGVISCFSFRHFILVFCSRILFPDGTSPSKLKLNARVNPLGAVWAKDYQEAEANTYSAAMVDYLEQRLSANLERNNRIPPSFMNRSSLCRVVLFDHDNKGLEASVRLSVNDVITEVRGEFMMLEEYEHHFDPISDYNRYVMFYQGFGDRTIVLEATRYGNSARFVRRSCIPNCRLDHTVVQGKFQLLIRASMELVPGTELTIPFDLDYRACRYPLECACARSRCPVLKWCRKLVRHKVVPNLDYSKYIESQLRVLSKPLSQESPNSRTTSFEHSGLTGSPLLRSTMGSSMSSFSNLNTSPTPSTRLRKELSDTNSPLEDDSTKSSGYRPLRASGSCDGYTTVVDENEVPHCSKVVLDSAPNQENRSNASTLLCEDADKIVFATQSPPAVNRNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3N1</accession>
    <name>A0A075A3N1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162158.1">
        <property type="nucleotide sequence ID" value="XM_009163894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3N1"/>
    <dbReference type="GeneID" id="20314374"/>
    <dbReference type="KEGG" id="ovi:T265_00186"/>
    <dbReference type="CTD" id="20314374"/>
    <dbReference type="OrthoDB" id="10050565at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="360"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="559"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="97139" checksum="72AB69881B147BDA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3V1</accession>
    <name>A0A075A3V1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174191.1">
        <property type="nucleotide sequence ID" value="XM_009175927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3V1"/>
    <dbReference type="GeneID" id="20323924"/>
    <dbReference type="KEGG" id="ovi:T265_09756"/>
    <dbReference type="CTD" id="20323924"/>
    <dbReference type="OrthoDB" id="6251906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="226" mass="25710" checksum="56AC17E11951F006" modified="2014-10-01" version="1">MTEQPMEPPDRTTNRGQRSSPATSTYINTRNTTERTTTNPPLRTTTLPNNALMMSHRLVMKRLQSNCPAQRTNQRPSTLPELQTFTSIENMHICSKITANGFSNIQFAHIASDVCTPGDQLKRPRGIIVLKNQPTERRGSSCFFCPVIMETHFDSADLVENANSMRLPDYNQRNPRVWFHQVEAVFTTRRITSQAKQFSYVVQHLPCDVATEMEDLLEDVPKGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4B2</accession>
    <name>A0A075A4B2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165839.1">
        <property type="nucleotide sequence ID" value="XM_009167575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4B2"/>
    <dbReference type="STRING" id="6198.A0A075A4B2"/>
    <dbReference type="GeneID" id="20317349"/>
    <dbReference type="KEGG" id="ovi:T265_03162"/>
    <dbReference type="CTD" id="20317349"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF48">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="350"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="549" mass="61722" checksum="9DBBD60223D710D8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4X8</accession>
    <name>A0A075A4X8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_12651</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162997.1">
        <property type="nucleotide sequence ID" value="XM_009164733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4X8"/>
    <dbReference type="STRING" id="6198.A0A075A4X8"/>
    <dbReference type="GeneID" id="20326819"/>
    <dbReference type="KEGG" id="ovi:T265_12651"/>
    <dbReference type="CTD" id="20326819"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="167"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="277"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="434" mass="46919" checksum="F8A8023EC8A32C71" modified="2014-10-01" version="1" fragment="single">RFDVNNRTSKNDELETAPHRCCSRFALFFFAYEFLDVLNAIAIRRGISDLPESHVLLQKTCRMFATDYLIPRAAAHDTEKKCPREALSKLGELGLMSMLVPERYGGAGLDYLAYAIAMEEISRGCASVGTIMSVQNSLFFAPLLKYGTQNQIEAFLGPFLTGEKLGCFALSEPGNGSDAGAASTTATRKGPTWVLNGTKCWITNGLEAEAAIVFATTNRSLKHKGISAFLVRKPTEGLVVGKSEDKLGIRATSTVTLNFDDCVVHERDGCGLLGLEGNGFKIAMKTLDGGRIGIAGQALGIAQAALECALDYAGKRSAFGSPIGKLQAIQFKLADMETRLHSARLLTWQAAHLLDKEAPVTKAAAMAKLAASEAATFVSHQAIQILGGMGYVNSMPAERHYRDSRICEIYEGTSEIQRLVIAQNLFKEHGIPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A531</accession>
    <name>A0A075A531_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_13123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165579.1">
        <property type="nucleotide sequence ID" value="XM_009167315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A531"/>
    <dbReference type="STRING" id="6198.A0A075A531"/>
    <dbReference type="GeneID" id="20327291"/>
    <dbReference type="KEGG" id="ovi:T265_13123"/>
    <dbReference type="CTD" id="20327291"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="73"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="176"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="308" mass="35477" checksum="2BD809BCC57BE67B" modified="2014-10-01" version="1" fragment="single">VLAGQSAVCSTKQRTPQSTQRKLNLTAPTWEEIIARHTPGTSIHDAAKLCSEGSCTPLSSLYHIPTPDTVPPALWRPNNCTSSQAVALLIPYRNREMNLRIFLNNMFSFLCNQQLEYSIIIVEQLENTSFNRAALFNIGFRESERIRRFDCFILHDVDKLPEDEYLPYRCESNPVHLSGALDIFGYGMPYKEFFGGVSAISRDQMIRIRGLSNKYYGWGGEDDDLAQRLVHMRYQIKRHPLEFSRYTSIFHEPDKRNEKNPARHDLLKSAETRMMVDGYPETRYTITFAGPKLNGLIYWISVKIPEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5W9</accession>
    <name>A0A075A5W9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162627.1">
        <property type="nucleotide sequence ID" value="XM_009164363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5W9"/>
    <dbReference type="STRING" id="6198.A0A075A5W9"/>
    <dbReference type="GeneID" id="20314747"/>
    <dbReference type="KEGG" id="ovi:T265_00559"/>
    <dbReference type="CTD" id="20314747"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23710" checksum="51EA7D0B66D65A14" modified="2014-10-01" version="1">MPPEGSTRAGILPGCPSLDRGSRVAEVGFEPRTFWSVNSRSNHLGHLAQSRSHSRRIAYVCLKILKLFRLDFPVSSNGLLFKRTASEYRRATQTCQTDPTAGNTVLPTTTSEDFRPFIRRLPELLEKMPYHPFAFRHTCTVAIALSLFCTAFEFLDVPVFWPILVLYFLLLFYLTMKRQIMHMIKYHYLPFTYGKPRHHSSTAGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6E6</accession>
    <name>A0A075A6E6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596868">
        <property type="protein sequence ID" value="KER23019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173221.1">
        <property type="nucleotide sequence ID" value="XM_009174957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6E6"/>
    <dbReference type="STRING" id="6198.A0A075A6E6"/>
    <dbReference type="GeneID" id="20323181"/>
    <dbReference type="KEGG" id="ovi:T265_09002"/>
    <dbReference type="CTD" id="20323181"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="26085" checksum="8247E8360646F161" modified="2014-10-01" version="1">MPGNELSDMFHSIPLITRYWFSGTILFSLLGKLGIIDPMRMILFWDGVHKYEIWRPITALLFYPINPSTGFHFLINLYFLYSYSSRLENGKFRFPQFLLEPMVLTVIYIWSQMNRDVIVQFWFGMQFKAMYFPWVLVIFNLIVRGSVLMELTGIVVGHMYYFFTSQYPQEHGGPVLLKTPSFLYRLFPNQVGFVAGFGQAPRAREAPAAPSAPRFPGRGQALGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A790</accession>
    <name>A0A075A790_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162002.1">
        <property type="nucleotide sequence ID" value="XM_009163738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A790"/>
    <dbReference type="STRING" id="6198.A0A075A790"/>
    <dbReference type="GeneID" id="20314269"/>
    <dbReference type="KEGG" id="ovi:T265_00081"/>
    <dbReference type="CTD" id="20314269"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER34222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="470" mass="51326" checksum="5BFE5971BE74E8C2" modified="2014-10-01" version="1">MDTGTPRLREIVPACLFAGMGMVFAGTYLDKVKRTQAGQFDPQLLAIIPPLIGLKGNLEVTLSSRLATLMQGVSAAIVISTLCVIMYSPTEYKFANLLHLTAVSVITCALALCTLSFLVFALIVCCMYLGTDPDNVAPPMAAAFGDLGTVTLLLWANYYSTEFPDGAQILAFVIVLAVFFFGPFLLKCDETMNTPAELRGLLINRNTLMGSIMPLLSGQVLAHFDQRLKNLARLQIAINGVGGCFGSIVVSRMITRIHAARKRPLSPPWSRKPSNEVDQNQHEHYTSPECSSDVPHNSETNSSPFISSLPCNCWHLISTEHDYNVPNSQQRQLELDVESDSRRASRLILFCCLPIHLILAMVSLMLHKMLESEDAHETLPLSTIVAYLSAGFLQVFIVLHFATWIVVTCWRHLTSPRSGASCLCASHTTDPHPSLASLDLAAIALTTSLGDLIGSVLLATSMHLSQTMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8V5</accession>
    <name>A0A075A8V5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596829">
        <property type="protein sequence ID" value="KER23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172318.1">
        <property type="nucleotide sequence ID" value="XM_009174054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8V5"/>
    <dbReference type="GeneID" id="20322477"/>
    <dbReference type="KEGG" id="ovi:T265_08298"/>
    <dbReference type="CTD" id="20322477"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="37558" checksum="5F98D22CCFA26FF6" modified="2014-10-01" version="1">MPIGLLLDSVQTQCRGPKTGITLLLWYAEWCQNGLSLNLKGRVYQATVLAALLHGCETWPIRAAELRRLQVFDNRCLRTIARRSMKEITKRLGAVGATRLPGWGPRDPHCAWLETLQDMAANRCQWRSCCQFLSRLPELSNKSWLYGSEASVLNADVSADFPTERSVVRIRPLPLDFPCLGLGDLAVSQPSYFFRHRKGAHGSNPTRSASRLPLSDSIPALVQPSGGMAFGHRKGAKAERFLRCEFNDRNAHGSNPTLASLMLLSRLEKNGSTSVLVGLSRGAAARHTKRKLDRCALRTSKDFQCSTIDVLGALPESGGNTGSAILKYVEWYSGETTHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAU7</accession>
    <name>A0A075AAU7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163240.1">
        <property type="nucleotide sequence ID" value="XM_009164976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAU7"/>
    <dbReference type="GeneID" id="20315221"/>
    <dbReference type="KEGG" id="ovi:T265_01033"/>
    <dbReference type="CTD" id="20315221"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7344" checksum="DE03E01A17B01AB8" modified="2014-10-01" version="1">MYTHFETSKPRDSAGFQNSLIGLNDQRKSPSADGSSVSIRYRIVKQQVELCSGDARAISADDPLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD82</accession>
    <name>A0A075AD82_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170366.1">
        <property type="nucleotide sequence ID" value="XM_009172102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD82"/>
    <dbReference type="GeneID" id="20320936"/>
    <dbReference type="KEGG" id="ovi:T265_06757"/>
    <dbReference type="CTD" id="20320936"/>
    <dbReference type="OrthoDB" id="6271097at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27283" checksum="C1772A80A38D99BC" modified="2014-10-01" version="1">MQDQPDHDGINNQPITSPHDSCLTPFDSAHTVAYVPNSNSFPIFRLKEQLHEDQHYYSLNERDRIQDAGYRKSTSSYSFASSPKGGGINANFLDCRLRYIRQTRRLQKYLRVTPEGNLLVNDVKHLYHDATNWQPPESKESLASKRESNPFATLISTPKLKRIYAAFWNMESRHDYSSPNSTQLLKYVNSSDTQTLQQSHVSQAQESVHSPEQLQNNSSETGPTLDSSCEQETALEMAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGF9</accession>
    <name>A0A075AGF9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167573.1">
        <property type="nucleotide sequence ID" value="XM_009169309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGF9"/>
    <dbReference type="GeneID" id="20318727"/>
    <dbReference type="KEGG" id="ovi:T265_04545"/>
    <dbReference type="CTD" id="20318727"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="183" mass="20865" checksum="4D9AC68C7ACA6C9D" modified="2014-10-01" version="1">MPNHRLPKRVLFSMPNSEWRKQRGGQPLTWQRSMKEITKRLGAVGATRLPGWGPPECAARRPPHDSVGTIFEISQYIFIKETTHKVAENSSTAQDRFRPSWDSSGRRNLRVSVNLMIYLDPKICVKYGRPSGGQLMIWKPSMKYFNSKLETTSKCRLFQRGPPDKTKQSPTTLAAMAVSHSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI68</accession>
    <name>A0A075AI68_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165104.1">
        <property type="nucleotide sequence ID" value="XM_009166840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI68"/>
    <dbReference type="GeneID" id="20316749"/>
    <dbReference type="KEGG" id="ovi:T265_02561"/>
    <dbReference type="CTD" id="20316749"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49547" checksum="499A27FE2F7A462E" modified="2014-10-01" version="1">MLILCNVQDLLCVHYPLLQIKGKLIPFCGCSEVVVRTDRVLDSHFWRLCGSNFKAFAPLRLGWNRVECSCKHFSIHCRLCYSPAPDSFNVVQPLYVVCSDGNGSFQNENGYNSGSPESAVRRIGFAVQLLQSLTAESFFSEYGQRYTFACNEDRAELICRLHRSRLTCTEIYSSQPIDVWSKLARELCNAYPQAFMNTKWIAFMADTRYTAPESQSNLTYQELSKFAKAHFALGAGGLALLGTATLHAWPEDLGSLNTALWNTRRIDHSTVMDDTAYRHTYWAAFATGLGSVWHELGHCLGLDHSLEGIMNRGGDDVHLCIAFPPTGSTCGHGCDKLGPMVSTSDVDFIPLRLNPRPPMPTVLQHERCILRHQPEAADTDRPSAAFNPWSLCHSIWHQGSAFWGHEQIVKLLKSRWIVCASSVAKGNDYVSMKRKVTVDACPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ0</accession>
    <name>A0A075AIJ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_02088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164511.1">
        <property type="nucleotide sequence ID" value="XM_009166247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIJ0"/>
    <dbReference type="STRING" id="6198.A0A075AIJ0"/>
    <dbReference type="GeneID" id="20316276"/>
    <dbReference type="KEGG" id="ovi:T265_02088"/>
    <dbReference type="CTD" id="20316276"/>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="14993" checksum="7795A07EC126CB72" modified="2014-10-01" version="1">MGHQIYFYSAPYPVSMGNFPQPGNEDLPPPYPGPPGETSPPVHPTNTDMPYPPTETQTVIVTQPLGFTPGTTFCVYCQKSVITNVSYIPGSLTYLLCVVIFLLGGCLGCCFIPFCCNDCEDAVHTCSVCGTTLGVRTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ34</accession>
    <name>A0A075AJ34_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163636.1">
        <property type="nucleotide sequence ID" value="XM_009165372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ34"/>
    <dbReference type="STRING" id="6198.A0A075AJ34"/>
    <dbReference type="GeneID" id="20315554"/>
    <dbReference type="KEGG" id="ovi:T265_01366"/>
    <dbReference type="CTD" id="20315554"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051983">
        <property type="entry name" value="WSB_SOCS-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622:SF2">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15622">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="524" mass="58556" checksum="661D2BB9A58868FE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ91</accession>
    <name>A0A075AJ91_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163321.1">
        <property type="nucleotide sequence ID" value="XM_009165057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ91"/>
    <dbReference type="GeneID" id="20326875"/>
    <dbReference type="KEGG" id="ovi:T265_12707"/>
    <dbReference type="CTD" id="20326875"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9645" checksum="7039D04866966710" modified="2014-10-01" version="1" fragment="single">CRSPVAPFRYQNAMPPEESKRVGYWPGCPNLDGGSQEAEVGLEPRTFRKLLTRLLKTLRQPMTGFVLPLRAHQIGEVPEFSSTLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG0</accession>
    <name>A0A075AJG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162952.1">
        <property type="nucleotide sequence ID" value="XM_009164688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJG0"/>
    <dbReference type="GeneID" id="20315004"/>
    <dbReference type="KEGG" id="ovi:T265_00816"/>
    <dbReference type="CTD" id="20315004"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="216" mass="24576" checksum="CA54928ED12F6B88" modified="2014-10-01" version="1">MDGGEISKFHLRFHITSKYEDEVKAFRTFSKPCELHSLQACMREENQDHQPPRYSKPQKSTDELPEGFCRCVRLELRQPVIQLAEYSVSLCVHCDSSALAGPTSLICYICDLRICNVGWRLDCRSRLVPRRDASLTPDCTILLRDDAVASSAVGDKPPKLCDPYFVPLEESQIYGDQHPEWITLSLTICSSVTRKIIEFKNFGGAKYRNDNRLNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJQ3</accession>
    <name>A0A075AJQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Egal-1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162492.1">
        <property type="nucleotide sequence ID" value="XM_009164228.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJQ3"/>
    <dbReference type="GeneID" id="20314643"/>
    <dbReference type="KEGG" id="ovi:T265_00455"/>
    <dbReference type="CTD" id="20314643"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="371"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Egal-1 winged helix" evidence="2">
        <location>
            <begin position="628"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118968" checksum="A2F193BAE0D6F670" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJR6</accession>
    <name>A0A075AJR6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162307.1">
        <property type="nucleotide sequence ID" value="XM_009164043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJR6"/>
    <dbReference type="GeneID" id="20314486"/>
    <dbReference type="KEGG" id="ovi:T265_00298"/>
    <dbReference type="CTD" id="20314486"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10326" checksum="9E6400014D8A270B" modified="2014-10-01" version="1">MHQFIISRLQCAATYPSSKSLVNETAAATTTVPRVRGAATADKRSSNVIGPNTGSRIQGFTHSYTGSRLLPKFPGRFCSCQSVTVVHLKGTSEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTA8</accession>
    <name>A0A074YTA8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL616373">
        <property type="protein sequence ID" value="KER18031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178222.1">
        <property type="nucleotide sequence ID" value="XM_009179958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTA8"/>
    <dbReference type="GeneID" id="20330513"/>
    <dbReference type="KEGG" id="ovi:T265_16348"/>
    <dbReference type="CTD" id="20330513"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="10329" checksum="C838BA67E1F0CFFF" modified="2014-10-01" version="1" fragment="single">MGVVTLRRVDGTMQTGRVEALYVDAGGTMVGVMVGGLDVTGVEGFPRIVIAPSSRPDAVVSGAVGEGDAVSPSSPDQRPVEIVGDKAAVRAELIDAWCSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTB5</accession>
    <name>A0A074YTB5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL615688">
        <property type="protein sequence ID" value="KER18036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178217.1">
        <property type="nucleotide sequence ID" value="XM_009179953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTB5"/>
    <dbReference type="STRING" id="6198.A0A074YTB5"/>
    <dbReference type="GeneID" id="20330507"/>
    <dbReference type="KEGG" id="ovi:T265_16342"/>
    <dbReference type="CTD" id="20330507"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="7181" checksum="ECD6D91B85532D0F" modified="2014-10-01" version="1" fragment="single">MFSSPVVPEHVTELPCFRLLPPGCYWDRADGWTTFDMRTQFERFGLPNAAWTLTDINRDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTE7</accession>
    <name>A0A074YTE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_16318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL613411">
        <property type="protein sequence ID" value="KER18066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178187.1">
        <property type="nucleotide sequence ID" value="XM_009179923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTE7"/>
    <dbReference type="STRING" id="6198.A0A074YTE7"/>
    <dbReference type="GeneID" id="20330483"/>
    <dbReference type="KEGG" id="ovi:T265_16318"/>
    <dbReference type="CTD" id="20330483"/>
    <dbReference type="OrthoDB" id="1878647at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER18066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7538" checksum="BC092D43D56C9BFA" modified="2014-10-01" version="1" fragment="single">MSRSQNPLKGDWICSDSKCGNTNSGKWDSCRRCDKRRKGTQNANGAEGLGKEGAAKSKGLFSPDDWNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU16</accession>
    <name>A0A074YU16_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604073">
        <property type="protein sequence ID" value="KER18296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177957.1">
        <property type="nucleotide sequence ID" value="XM_009179693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU16"/>
    <dbReference type="GeneID" id="20326488"/>
    <dbReference type="KEGG" id="ovi:T265_12320"/>
    <dbReference type="CTD" id="20326488"/>
    <dbReference type="OrthoDB" id="10260387at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7755" checksum="94D782BEE8054757" modified="2014-10-01" version="1">MKRTDTFDVEKVYSQLVLGENSAVVGFIHGNGDDNLTQLLARLETEYAGNAIWTHEQDIDLRIMIRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW81</accession>
    <name>A0A074YW81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597371">
        <property type="protein sequence ID" value="KER19031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177223.1">
        <property type="nucleotide sequence ID" value="XM_009178959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW81"/>
    <dbReference type="STRING" id="6198.A0A074YW81"/>
    <dbReference type="GeneID" id="20326213"/>
    <dbReference type="KEGG" id="ovi:T265_12045"/>
    <dbReference type="CTD" id="20326213"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="214" mass="25328" checksum="F04A487F27BAB6AE" modified="2014-10-01" version="1">MAQRIIRNPVEVSVHFDRVVWWTGKVKEIGEAQKAGNAQRLFQLIRTIDPRKPTVEERLIPAAPGWRRYKVWLLTDVSGVLVVSFYPNCLSDCLEVQAPRSDYGYPEVNYVRTHVLYRDMPSRCQCGNWFKLVDMERFEQAREEKWQKIKDEPENAKLLKELAETEEELNQLFQKGRGMTMYTRGATEITEKLSIAWKRYRKTFLEIRKKMDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXA3</accession>
    <name>A0A074YXA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597211">
        <property type="protein sequence ID" value="KER19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176823.1">
        <property type="nucleotide sequence ID" value="XM_009178559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXA3"/>
    <dbReference type="STRING" id="6198.A0A074YXA3"/>
    <dbReference type="GeneID" id="20325965"/>
    <dbReference type="KEGG" id="ovi:T265_11797"/>
    <dbReference type="CTD" id="20325965"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="301" mass="33044" checksum="29B83F5B7FDF6537" modified="2014-10-01" version="1">MNSVPVWQTSLKCSNPHLKHMEEDLLYHLGLSTKSVNFRKEFGDVKFVCVAGSAYRIKAFAQMLAKEAGLSTDLPNLAADGGRFVLYKVGAVLAADHGMGAPSISILLHEMFKLLHYAHCTDVTFIRLGTSGGIGVEPGTLVITTEALDTAFESFYSLRILGKTVKRPAPLDPNLADELYELAQTLPDNVPVVKGKTVCANDFYEEQARLDGAFCQFTESEKMAYLNQACSMGVRNFEMECTCFAAQCYLAGVRAAIVCVTLVNRLESDQVRLNPKTYARIQQLPGQLVLALLRKHNALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYU3</accession>
    <name>A0A074YYU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin-folding cofactor D ARM repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL602288">
        <property type="protein sequence ID" value="KER18367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177886.1">
        <property type="nucleotide sequence ID" value="XM_009179622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYU3"/>
    <dbReference type="STRING" id="6198.A0A074YYU3"/>
    <dbReference type="GeneID" id="20330274"/>
    <dbReference type="KEGG" id="ovi:T265_16109"/>
    <dbReference type="CTD" id="20330274"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="1">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="18167" checksum="3B9F47285EF72009" modified="2014-10-01" version="1" fragment="single">MVTLDKLFVSSSKHRLGRMCNRLGSSMVSDVLAALLSLCTRLEPFTAWHGACLALAELGRRSLLLPSKLPEASQLVVVSQHHVIPVVLRALFYDERSGDHNYGSNVRDAACYVCWAFARAYRAQDFSPYVNQVASALILVSLFDREVNVRRAAAAAFQENVGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1E1</accession>
    <name>A0A074Z1E1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 DOCK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597020">
        <property type="protein sequence ID" value="KER20788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175452.1">
        <property type="nucleotide sequence ID" value="XM_009177188.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z1E1"/>
    <dbReference type="GeneID" id="20324896"/>
    <dbReference type="KEGG" id="ovi:T265_10728"/>
    <dbReference type="CTD" id="20324896"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="5">
        <location>
            <begin position="2581"/>
            <end position="3062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1910"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2024"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2179"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1929"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2035"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2054"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2179"/>
            <end position="2192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3092" mass="340095" checksum="07D889FBB9C25C24" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z256</accession>
    <name>A0A074Z256_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597175">
        <property type="protein sequence ID" value="KER19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178408.1"/>
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    <dbReference type="STRING" id="6198.A0A074Z256"/>
    <dbReference type="GeneID" id="20325857"/>
    <dbReference type="KEGG" id="ovi:T265_11689"/>
    <dbReference type="CTD" id="20325857"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19269" checksum="FF8B72026D24E283" modified="2014-10-01" version="1">MTQMPDSEGQKQVGGQHLTWQRSIKDITKPVGAVGAPCLPGWGLRDPHCSWLETLQDVAADRCCLGMIVGAPESILDRCTQVRTPNGRVLLTPELKDEILRKLATYATGRETLRCLALASRDDPPELSQFNLTDPTNFKEYETSHFTPCRLFEHPSGVPTSFLSNFVINELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Y5</accession>
    <name>A0A074Z2Y5_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596973">
        <property type="protein sequence ID" value="KER21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176640.1"/>
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    <dbReference type="STRING" id="6198.A0A074Z2Y5"/>
    <dbReference type="GeneID" id="20329277"/>
    <dbReference type="KEGG" id="ovi:T265_15112"/>
    <dbReference type="CTD" id="20329277"/>
    <dbReference type="OrthoDB" id="10070972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040436">
        <property type="entry name" value="Disconnected-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021:SF0">
        <property type="entry name" value="DISCO-RELATED, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15021">
        <property type="entry name" value="DISCONNECTED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="889"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
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        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
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            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="889" mass="96701" checksum="84A4C3B8E2BB4651" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Z9</accession>
    <name>A0A074Z2Z9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596971">
        <property type="protein sequence ID" value="KER21373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074Z2Z9"/>
    <dbReference type="GeneID" id="20329269"/>
    <dbReference type="KEGG" id="ovi:T265_15104"/>
    <dbReference type="CTD" id="20329269"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703919" description="Methyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="619" mass="70098" checksum="01B9BC5F0B4C2079" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5Z1</accession>
    <name>A0A074Z5Z1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_10599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597006">
        <property type="protein sequence ID" value="KER20967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009177019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5Z1"/>
    <dbReference type="GeneID" id="20324767"/>
    <dbReference type="KEGG" id="ovi:T265_10599"/>
    <dbReference type="CTD" id="20324767"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7157" checksum="2F8416517AC850FC" modified="2014-10-01" version="1">MGVKFVRLRDDLLKTDLKWNLALREGWKGTRGGQTMTWQRSGRAITSKLSCVDHCRIPGWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8G3</accession>
    <name>A0A074Z8G3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="ovi:T265_09925"/>
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    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    <dbReference type="Pfam" id="PF00079">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10227" checksum="7C93FF454354789A" modified="2014-10-01" version="1">MASEEVKQSVCNFAVDLYRQVVKKQGVGLSNVFISPLSIYTAVAMTMAGADGQTKNEILASLHLSKVDNPNEAVGSIVQQYLRSKTGVELALILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8I9</accession>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="STRING" id="6198.A0A074Z8I9"/>
    <dbReference type="GeneID" id="20322848"/>
    <dbReference type="KEGG" id="ovi:T265_08669"/>
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    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="F:galactosylceramidase activity"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="galactocerebrosidase precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23448.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="614" mass="68439" checksum="E8C9AC7E007E0A76" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Z3</accession>
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        </recommendedName>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="project" value="InterPro"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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                <person name="Tan P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="290" mass="32428" checksum="9F70DD0A2A099FD5" modified="2014-10-01" version="1" fragment="single">MLSEPRKKARYSTNPNGNLWVNDTAGFGRQMLERLGWTPGSGLGKKEDGISRPLKVFPHSLTHQTDRSFQPQGQKGREGLGKKLDYQLGGSKQLDDYAQLLKELNSSYESKKRSNSSTSLEDLSKSSSNRLHYPKFVRAKDASRYDEKSLAIILGLKPAESKQHSTPEPTEPPKDFGVKTVSSSLSINDYFKKRRAELQESRLQTNNKSTLHNPDLQNETGTSGKRRRSELEQNPSPKNPRSECSVSWDAHNRESSVGTPSGEIDSAQILLPADCNETITTRRTKNVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAX8</accession>
    <name>A0A074ZAX8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597061">
        <property type="protein sequence ID" value="KER20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175852.1">
        <property type="nucleotide sequence ID" value="XM_009177588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAX8"/>
    <dbReference type="GeneID" id="20325211"/>
    <dbReference type="KEGG" id="ovi:T265_11043"/>
    <dbReference type="CTD" id="20325211"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6824" checksum="E735065616F8B6A8" modified="2014-10-01" version="1">MKTETGAVDKASGAAAHGSLCCKRQDLCNSRYIKFGGTFSEGKNNAYNVERTSYDPEYESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBL7</accession>
    <name>A0A074ZBL7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175634.1">
        <property type="nucleotide sequence ID" value="XM_009177370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBL7"/>
    <dbReference type="STRING" id="6198.A0A074ZBL7"/>
    <dbReference type="GeneID" id="20325044"/>
    <dbReference type="KEGG" id="ovi:T265_10876"/>
    <dbReference type="CTD" id="20325044"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="230" mass="26482" checksum="569C19EBD9A76B2B" modified="2014-10-01" version="1">MKQETLHRGLLKLFSIVDLDGDNRVSYNELNLGFERFGFTESECSKFMRMFDKDSDGYLTLGEYKAAFGIPEDLQEESHCKVTKTMSKGALLALFEKLDVNWQDKITQEELHKGMLELGATEADVESLMSFLDMDDDGLISKNEYHVALCMSLDPEIDWDIVFEQLDCDRSGDISVTELKHVFDRIGIPIMTSGIMQWIKQHDKNNDGKLDYQEFLSFVGTQRKLSRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCF1</accession>
    <name>A0A074ZCF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597013">
        <property type="protein sequence ID" value="KER20880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175382.1">
        <property type="nucleotide sequence ID" value="XM_009177118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCF1"/>
    <dbReference type="GeneID" id="20324835"/>
    <dbReference type="KEGG" id="ovi:T265_10667"/>
    <dbReference type="CTD" id="20324835"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14287" checksum="1C5B995F9FE66501" modified="2014-10-01" version="1">MTFSVLGINHERLGIPVLGDGHFGLGYPSARRRLGDSYILNVLAEQQLIDYKRFTLLCVCADHRNDFEPDAQVVFGSHHKIYPEEFHMVQADVSHGGWKIEVLGLSTLAGQISSIGFTASLDSTTWLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCS9</accession>
    <name>A0A074ZCS9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171287.1">
        <property type="nucleotide sequence ID" value="XM_009173023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCS9"/>
    <dbReference type="STRING" id="6198.A0A074ZCS9"/>
    <dbReference type="GeneID" id="20321669"/>
    <dbReference type="KEGG" id="ovi:T265_07490"/>
    <dbReference type="CTD" id="20321669"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="62372" checksum="9F16F0501C265ACA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD52</accession>
    <name>A0A074ZD52_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172681.1">
        <property type="nucleotide sequence ID" value="XM_009174417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD52"/>
    <dbReference type="STRING" id="6198.A0A074ZD52"/>
    <dbReference type="GeneID" id="20322751"/>
    <dbReference type="KEGG" id="ovi:T265_08572"/>
    <dbReference type="CTD" id="20322751"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="36229" checksum="1AEDC10BC0F0DF0B" modified="2014-10-01" version="1">MVRITPELVENSPQFTNAIKDRELDLRGYKFPVVENLGSTLDQFDTIDLSDNEIRKLDGFPLLRRLKSLILTNNKIVRLAEDLGQQIPNLNTLILTGNAFSELKELEPLSTCDKLSFLSLVHCPVTMRANYRLFVISRLPALRFLDYRRVTQSERKLARSMFKRLPAIAATPTNVVKNPVGKQVNGLPSDHRTTTVKTFIPGAPINQPANMTSSGREENDSGSRGSSEAGATTNEPAMPPPPGPTHPGSKRPASGGTTQDLFAIQEAIKRAKSMDEVERLHQLLSSGQFAGFAAQWQQHLRQQQQQQQQQQPQQSPAPESEQSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDQ8</accession>
    <name>A0A074ZDQ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174930.1">
        <property type="nucleotide sequence ID" value="XM_009176666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDQ8"/>
    <dbReference type="STRING" id="6198.A0A074ZDQ8"/>
    <dbReference type="GeneID" id="20324498"/>
    <dbReference type="KEGG" id="ovi:T265_10330"/>
    <dbReference type="CTD" id="20324498"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="219"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="313" mass="34818" checksum="909E7BB0660F3FCE" modified="2014-10-01" version="1">MSKLREPRRYQLFQMSTEPVMRPEWARFVCGGIAGAVSRTMTAPIDRLKVLRQIGTPEMMGKNSIQCWRLMFLEGGITALWRGNGVNVLKNCPESAIRFGLHGWLKSVLFPEVKGNLRPDQRLLVASLAGAVSLTCTYPIEILKTRMAMRKSTDPKSIVACVRRVYGQGGLSGFYRGYKISMLSYVPYSGMELAIYEMLKRRYLHYRSSSSGIAPTKPVPALVTITLVTTSCCIPILIVYPANLLRTRYQASDSPRAAPVLSSLRSIWQTSGFCGLYQGMGASLSKTLPSVCITYVVFEFMSDLMRVPGLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEC4</accession>
    <name>A0A074ZEC4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_08251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596827">
        <property type="protein sequence ID" value="KER24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172262.1">
        <property type="nucleotide sequence ID" value="XM_009173998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEC4"/>
    <dbReference type="STRING" id="6198.A0A074ZEC4"/>
    <dbReference type="GeneID" id="20322430"/>
    <dbReference type="KEGG" id="ovi:T265_08251"/>
    <dbReference type="CTD" id="20322430"/>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="220" mass="24563" checksum="0CE68BF1CD6E88E1" modified="2014-10-01" version="1">MFDVMLCTASILNLAAISIDRYVAVTKPIFYSKHSNNYRVGISIAVAWILSFVIALPIACGLNNMPHRQNNICVLYNPEYIIASSFGSFYLPSAVMIILYYRVFDTIRSRTRRKIHTNGTMIVRPNSLYRDSNDVANMQCAGTSSTSRDSSALSENRLRIANIPVTVNDLTRPDTTDLSVIELSPQLTDKVQAYSACSKEIDGPRENLRSSSARMFSPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZET0</accession>
    <name>A0A074ZET0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596944">
        <property type="protein sequence ID" value="KER21735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174519.1">
        <property type="nucleotide sequence ID" value="XM_009176255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZET0"/>
    <dbReference type="GeneID" id="20329188"/>
    <dbReference type="KEGG" id="ovi:T265_15022"/>
    <dbReference type="CTD" id="20329188"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="14115" checksum="0127ED5D80F71309" modified="2014-10-01" version="1" fragment="single">MTSVLNTNASLPYSHDLFESLIVKKRIKVMGWPPLCLRHSELGMENSTPSRLSIHEVTIVRILFLVIPHVFEKYTHLQINLVFTRDSTESLVYDILQLNVLHTGHLMFQLARYSRYRSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFH9</accession>
    <name>A0A074ZFH9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170193.1">
        <property type="nucleotide sequence ID" value="XM_009171929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFH9"/>
    <dbReference type="STRING" id="6198.A0A074ZFH9"/>
    <dbReference type="GeneID" id="20320795"/>
    <dbReference type="KEGG" id="ovi:T265_06616"/>
    <dbReference type="CTD" id="20320795"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="140"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="466" mass="52913" checksum="E2754521439F4892" modified="2014-10-01" version="1">MDFQILYGAYVGPLLEYANQVAYTGRTKDATLIERVQRAATRMVAGLKSVDYETRLAMLDLFPLEHLFMRIFTLASILPRAENIKSSATPFFTCERQPLTDKSKTDPGNLGKRLDPVYQSATNMVSDESWVVRENISDPEALLHIAKLAEHAERFTDMAAAMKKFTELKKPLSNDERNLFSVAYKNVVGARRSAWRVITSIKNKDSEDEKSPTNELRRKIENELEQVCKEVLNILEKNSLPSETTDDGLVFYHKMKGDYYRYLAEVQTGDKRNESVQKSHQAYEEATEKAKQSLSETHPIRLGLALNYSVFYYEIENSPDKACELAKSAFDNAISRLDQIKDDCGRRSVKLTSDPDLSQLLFAIRASASCLVHSFLHHYNHTGLLRFKSGIPNTNFPVNDGCSLQTSFYVISRILFLNDRTTSMSIFMEAAMLPPSPGEDGVERSVLKTAHSDRPVFGRSVRYKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG27</accession>
    <name>A0A074ZG27_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171627.1">
        <property type="nucleotide sequence ID" value="XM_009173363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG27"/>
    <dbReference type="STRING" id="6198.A0A074ZG27"/>
    <dbReference type="GeneID" id="20321937"/>
    <dbReference type="KEGG" id="ovi:T265_07758"/>
    <dbReference type="CTD" id="20321937"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11626" checksum="34B91BF4FE3D1880" modified="2014-10-01" version="1">MVKQICTKAELNKEVSGNSGKLVVIDFYAEWCGPCRAIAPKVASMAEEFKDVVFLKVNVDVGEELSKAYCITCMPTFVFLKGGEKVDSFSGADEKKLLEMVKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGF0</accession>
    <name>A0A074ZGF0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 148</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169856.1">
        <property type="nucleotide sequence ID" value="XM_009171592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGF0"/>
    <dbReference type="GeneID" id="20320533"/>
    <dbReference type="KEGG" id="ovi:T265_06351"/>
    <dbReference type="CTD" id="20320533"/>
    <dbReference type="OrthoDB" id="448087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="58898" checksum="A9F74CCEA6AEDDF7" modified="2014-10-01" version="1">MHKSVTQLKHELAFEEKQYTEESEGTYSHCRTSHLFLAHRNDMNRFSLNPKEMGIPDEAWAWKAPNDEFRAELLSEYIQIEALFFNRLSVLREQAEAMLAASNENEWSVTELELVDFFWDIFQRRAGANRKKMATHFLVTLLKHRSPTQLECLLEQRVREKQLKDHAMSIKRSWLKAREDLSIRIRASLIQACEAAEHSRMERQQHQMQRDLCSLLREQVSRWRKQRAEMIALEEEEQSKLREQAEVVASEKRAKQAATRKATKQKVGWRKQRAEMIALEEEEQSKLREQAEVVASEKRAKQAATRKATKQKVAAYKAAKMASKAREMEKEANRLAILRDIHKKQARIDTDRLVQAEKQRLAELHSQRVLAKERVDQEASRRQSRLDCIAKKVRPVVKSDPERITSETRAWRIKLEQRRQEAELLAELEESIPSRLITTLTTFSDAQLYADRRTRITAALHSAGLLDSDYARTLLSGVQPTVPPRKDSQTCEQLKQMLNPQSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGW3</accession>
    <name>A0A074ZGW3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169791.1">
        <property type="nucleotide sequence ID" value="XM_009171527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGW3"/>
    <dbReference type="GeneID" id="20320482"/>
    <dbReference type="KEGG" id="ovi:T265_06300"/>
    <dbReference type="CTD" id="20320482"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="22770" checksum="E30DB9C3B0C0E95C" modified="2014-10-01" version="1">MEETQKASSARRLFQLVRATRPREPQVSETNHPTAGTNNFVTTRCHSSGTCSLSRAPNDGSVRFAPCFASSNCASPGADTLRQLEISLQASTPSLSGCSHSEENKSTSCSCSHWARLTLMSAVYQKQEFKMQAHCVCPAIHRPLRQDMQGLRKDPCLDVGPFTELGNPTAKLGGQTNPRSAPSCLHSATLPDPCLTRYPMIVASARYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHX5</accession>
    <name>A0A074ZHX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596779">
        <property type="protein sequence ID" value="KER25377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170891.1">
        <property type="nucleotide sequence ID" value="XM_009172627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHX5"/>
    <dbReference type="STRING" id="6198.A0A074ZHX5"/>
    <dbReference type="GeneID" id="20321355"/>
    <dbReference type="KEGG" id="ovi:T265_07176"/>
    <dbReference type="CTD" id="20321355"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="22778" checksum="B54D5A40E1478668" modified="2014-10-01" version="1">MKVITKILCTVSGAHLPRWGPLDPYCSRLETVVFLLSVSIQVRVSNPTSASRLPLSRLGQRGTIPALVLPSGGMASRHRKSATVERLQKWSRHKIGIVNMPNSKWRKQRGGQPLTRKRSMKGITKSLGAVGATRLSGWGPHDTYCAWLETLQDMATNRCQWRSCCQFLSRLFELSHESWLYGSEVSVANTDVVPPMLLMMTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIN6</accession>
    <name>A0A074ZIN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169116.1">
        <property type="nucleotide sequence ID" value="XM_009170852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIN6"/>
    <dbReference type="GeneID" id="20319954"/>
    <dbReference type="KEGG" id="ovi:T265_05772"/>
    <dbReference type="CTD" id="20319954"/>
    <dbReference type="OrthoDB" id="6241670at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="677" mass="77991" checksum="0C30BD9E547C98BA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIP7</accession>
    <name>A0A074ZIP7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169345.1">
        <property type="nucleotide sequence ID" value="XM_009171081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIP7"/>
    <dbReference type="STRING" id="6198.A0A074ZIP7"/>
    <dbReference type="GeneID" id="20320116"/>
    <dbReference type="KEGG" id="ovi:T265_05934"/>
    <dbReference type="CTD" id="20320116"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="515"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="968" mass="108623" checksum="AB1CF421265F66F6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ81</accession>
    <name>A0A074ZJ81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_05568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168873.1">
        <property type="nucleotide sequence ID" value="XM_009170609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ81"/>
    <dbReference type="STRING" id="6198.A0A074ZJ81"/>
    <dbReference type="GeneID" id="20319750"/>
    <dbReference type="KEGG" id="ovi:T265_05568"/>
    <dbReference type="CTD" id="20319750"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="571" mass="63354" checksum="F210F26B7AD743FA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJE0</accession>
    <name>A0A074ZJE0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172786.1">
        <property type="nucleotide sequence ID" value="XM_009174522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJE0"/>
    <dbReference type="STRING" id="6198.A0A074ZJE0"/>
    <dbReference type="GeneID" id="20328802"/>
    <dbReference type="KEGG" id="ovi:T265_14636"/>
    <dbReference type="CTD" id="20328802"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19561" checksum="ECA1EC830ADA9BF3" modified="2014-10-01" version="1" fragment="single">STYYTESQLGHPVFETKYGRIAVNICYGRHHPLNWLMYGLNGAEIVFNPCATIDTLSETLWPIEARCAAIANNYFTVAINRVGTETFPNEFTSGDTKPGHTDFGHFFGSSYITGPDGVRTPGLDRIHNGLLIAEVDLNSCRQVRDSWGFRMTQRPELYAESLTEYVKKLQHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJE7</accession>
    <name>A0A074ZJE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170339.1">
        <property type="nucleotide sequence ID" value="XM_009172075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJE7"/>
    <dbReference type="STRING" id="6198.A0A074ZJE7"/>
    <dbReference type="GeneID" id="20328271"/>
    <dbReference type="KEGG" id="ovi:T265_14105"/>
    <dbReference type="CTD" id="20328271"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="641"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="922" mass="102284" checksum="7478131EF1C90823" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJF6</accession>
    <name>A0A074ZJF6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DENR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168793.1">
        <property type="nucleotide sequence ID" value="XM_009170529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJF6"/>
    <dbReference type="STRING" id="6198.A0A074ZJF6"/>
    <dbReference type="GeneID" id="20319689"/>
    <dbReference type="KEGG" id="ovi:T265_05507"/>
    <dbReference type="CTD" id="20319689"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DENR N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="22484" checksum="C7BF49DD540C29EF" modified="2014-10-01" version="1">MTSDYQYMPRSRPVPGVEYPLTVAYCGECTMPIEYCEFSSAPDKCRSWMEKNLPEEFERLTACDGAPPAEAPAKGRQVRGGKGSAPRKPAKQKITVFKTSRGKKKFTTSVVGLSTFEFRDNSVGIRRTVPKKIQMLQSYPAGVRLFQLYLGVQYPHWIQIDCEHCQLYLEPLGLDDEGTQFRLFRPDEQCVRIVGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJZ6</accession>
    <name>A0A074ZJZ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172605.1">
        <property type="nucleotide sequence ID" value="XM_009174341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJZ6"/>
    <dbReference type="STRING" id="6198.A0A074ZJZ6"/>
    <dbReference type="GeneID" id="20328756"/>
    <dbReference type="KEGG" id="ovi:T265_14590"/>
    <dbReference type="CTD" id="20328756"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="201"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="277" mass="31275" checksum="3932F8B0F465F94B" modified="2014-10-01" version="1" fragment="single">MFFTSLQEEEEQTQKVFQDFVATFEGDSKQRTWVKGGVVNPGSDGGSSGSSSENRIYKPVSKISEKQLNTDGTKPESKPNLPEKPPSLGKRRGKEQKKSKLEQFKEELKLIQQQREQRHALRQGKNVSPSAASTIHSELDLSDVGSRNREYRNPPLGFTQQSSGVGLLGDSGSPSNIYGRRGQRDRRDDYPYDFDGDRTTTNLFLGNLNPKVVIFSLLTFPQMTEQQLCEAFGRYGPLASVKIMWPRTDEERSRGRNCGFVAFMNRKDGERALDNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKE9</accession>
    <name>A0A074ZKE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_05226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596714">
        <property type="protein sequence ID" value="KER27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168445.1">
        <property type="nucleotide sequence ID" value="XM_009170181.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZKE9"/>
    <dbReference type="GeneID" id="20319408"/>
    <dbReference type="KEGG" id="ovi:T265_05226"/>
    <dbReference type="CTD" id="20319408"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1219"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="144228" checksum="20594B4050CF5E80" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI2</accession>
    <name>A0A074ZKI2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_06466</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169998.1">
        <property type="nucleotide sequence ID" value="XM_009171734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI2"/>
    <dbReference type="STRING" id="6198.A0A074ZKI2"/>
    <dbReference type="GeneID" id="20320645"/>
    <dbReference type="KEGG" id="ovi:T265_06466"/>
    <dbReference type="CTD" id="20320645"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER26272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24713" checksum="640147D21D999475" modified="2014-10-01" version="1">MIYFTLIARVADGLPLAATIQEDDRLSRHIVQYQNQAKQLVCRLTPTSPSRCSLIAGPYVFHYLLDRGVCYLILTESQFNRTKAFAFLEAIQTQFYGDYSSKIDTVSRPYAFLDFDRFIHQTQKTYTDTRSSNMNQLNVALQDVQRIMVQNIDDVLQRGEALSALDTRASNLSTMSKKYRQDAASLNMQSAWVFYVLLCVVILAIFTYIYFRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKX4</accession>
    <name>A0A074ZKX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168226.1">
        <property type="nucleotide sequence ID" value="XM_009169962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKX4"/>
    <dbReference type="GeneID" id="20319233"/>
    <dbReference type="KEGG" id="ovi:T265_05051"/>
    <dbReference type="CTD" id="20319233"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7607" checksum="708143FC209981FE" modified="2014-10-01" version="1">MATNQAQMEADQSSTSSEPTVEQNLAYYISVVDECGQSHWDGRGCPNVKLKTAQCETKMSWEYEIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKY3</accession>
    <name>A0A074ZKY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168584.1">
        <property type="nucleotide sequence ID" value="XM_009170320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKY3"/>
    <dbReference type="STRING" id="6198.A0A074ZKY3"/>
    <dbReference type="GeneID" id="20327916"/>
    <dbReference type="KEGG" id="ovi:T265_13749"/>
    <dbReference type="CTD" id="20327916"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000457">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="257" mass="29508" checksum="52099729D8A015DB" modified="2014-10-01" version="1" fragment="single">MHVRTWNSWLTDCHDWCISRQLWWGHRIPAYHVSIFNSETGAYDMLDGTLNSSWVVGRTEQEALEHACQQFNCHPDVIRLTQDTDVLDTWFSSQLFPFSVFGWPDDTPDLRAYYPGNLLETGHDILFFWVARMVMVGLRLLGKLPFDTVYLHAMVRDAHGKKMSKSLGNAIDPVDVIHGISLEALQKQLETGNLDPRELKRACEAQAKDFPKGIPECGTDALRFALCAYTKQGRNINLDILRVQGYRFFCNKLWNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM94</accession>
    <name>A0A074ZM94_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171764.1">
        <property type="nucleotide sequence ID" value="XM_009173500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM94"/>
    <dbReference type="GeneID" id="20322039"/>
    <dbReference type="KEGG" id="ovi:T265_07860"/>
    <dbReference type="CTD" id="20322039"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27805" checksum="D8698E8EDE6DA902" modified="2014-10-01" version="1">MRNSAKNKRQAKLYSSLEMEKNFGEETWLSGGANLLNGRSVIQTEPDHFDCFCLDIGNLTASQSPCFLRVAWQLDTERILQLNVHGLSLNKKGRVYQATVRAALLYGCETWPIRAADLRRLQGARWLEWLESEFTDRKVRGSNPTSASRLPLSRFGQPGSIPAFVLSSVAWQLGTKRVLQLNDINGVSPLDNIPNPRHEMPQWLDHEFTDPKVSGLNLDFYCLNFANLAVFRPSWFILVAWQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMH2</accession>
    <name>A0A074ZMH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596805">
        <property type="protein sequence ID" value="KER24560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171680.1">
        <property type="nucleotide sequence ID" value="XM_009173416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMH2"/>
    <dbReference type="STRING" id="6198.A0A074ZMH2"/>
    <dbReference type="GeneID" id="20321975"/>
    <dbReference type="KEGG" id="ovi:T265_07796"/>
    <dbReference type="CTD" id="20321975"/>
    <dbReference type="OrthoDB" id="10067503at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="10999" checksum="0C2E31162BA2970F" modified="2014-10-01" version="1">MFTLDQENICAAEPNEDATEHLLLPGRSGFEDELVREVAYFELTEFLIGELDSLNSMSLIRSIFPDEPAIDGDKAATTMTYTTNNTLHEESLRTIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMS1</accession>
    <name>A0A074ZMS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167646.1">
        <property type="nucleotide sequence ID" value="XM_009169382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMS1"/>
    <dbReference type="STRING" id="6198.A0A074ZMS1"/>
    <dbReference type="GeneID" id="20327712"/>
    <dbReference type="KEGG" id="ovi:T265_13545"/>
    <dbReference type="CTD" id="20327712"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029827">
        <property type="entry name" value="JDP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44500:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13917" checksum="AA2E9357118BF49C" modified="2014-10-01" version="1" fragment="single">VEQIEAEFRLKAREFHPDKNDNPDSTFQFQAINRAKQVLTDPKLRRQYECWKSSGLNIPFERWLLLKDQFHTCMHWCAVSNSADKMLPPANVSSGHGPFAAIEEHNPSNSLLSQFRAYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNJ2</accession>
    <name>A0A074ZNJ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167638.1">
        <property type="nucleotide sequence ID" value="XM_009169374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNJ2"/>
    <dbReference type="GeneID" id="20318781"/>
    <dbReference type="KEGG" id="ovi:T265_04599"/>
    <dbReference type="CTD" id="20318781"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9065" checksum="0288309D7C8CF9FD" modified="2014-10-01" version="1">MELSDGSLVPVVELAIKTKRSLWRQMTDPEFQDALDIIIIINDSNIGVGFDDDDDDDDVEGVLELGVNKSPPSVIWRHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNR1</accession>
    <name>A0A074ZNR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171274.1">
        <property type="nucleotide sequence ID" value="XM_009173010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNR1"/>
    <dbReference type="STRING" id="6198.A0A074ZNR1"/>
    <dbReference type="GeneID" id="20321656"/>
    <dbReference type="KEGG" id="ovi:T265_07477"/>
    <dbReference type="CTD" id="20321656"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14350">
        <property type="entry name" value="UBA_DCNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF32">
        <property type="entry name" value="DCN1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="31945" checksum="1BE0C6AFF05497D8" modified="2014-10-01" version="1">MCTTVTKFGSSSGRMFKLNAAQRERVRNFHEITQCSEKVAIHCLQTNNWKMEQAVDYFYRQNQVNSGVSVNEARIEQLFQRYRDPQCQDRILATGMEQFIANDLGIDPASMTTLILAWKFGAKTQGEFTREEFFRGFKELGCDSIDSLRAKLPSLNAEIANRDAFESLYLFTFSFANLDKHESKSLVLQYAIPYWDILLRGRFCHLDLWFRFLEEHHKRPISRDTWNLLLDFVDTIQPDMSNYDEEGAWPVLIDEFVEWARPQIQMECKASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNX7</accession>
    <name>A0A074ZNX7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171208.1">
        <property type="nucleotide sequence ID" value="XM_009172944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNX7"/>
    <dbReference type="STRING" id="6198.A0A074ZNX7"/>
    <dbReference type="GeneID" id="20321605"/>
    <dbReference type="KEGG" id="ovi:T265_07426"/>
    <dbReference type="CTD" id="20321605"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="14993" checksum="D1D0C4331D82210B" modified="2014-10-01" version="1">MSCSVSNQAQWGSRDPHPGSVSNQAQWGSRDPHPGRHFDAPYENALDGFFGKVEPPASFVSSRSLRLRLEHVEPGEEAKELEESSSCEGSQTIEVQSQCTQHPDDITPTGSAVWSTGNELDRWELIANEPNQRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP62</accession>
    <name>A0A074ZP62_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_05415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168677.1">
        <property type="nucleotide sequence ID" value="XM_009170413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP62"/>
    <dbReference type="STRING" id="6198.A0A074ZP62"/>
    <dbReference type="GeneID" id="20319597"/>
    <dbReference type="KEGG" id="ovi:T265_05415"/>
    <dbReference type="CTD" id="20319597"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="10">
        <location>
            <begin position="119"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="12">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="11">
        <location>
            <begin position="460"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER27602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="607" mass="67933" checksum="FE953DF670DE043C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX4</accession>
    <name>A0A074ZPX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167081.1">
        <property type="nucleotide sequence ID" value="XM_009168817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPX4"/>
    <dbReference type="STRING" id="6198.A0A074ZPX4"/>
    <dbReference type="GeneID" id="20318333"/>
    <dbReference type="KEGG" id="ovi:T265_04147"/>
    <dbReference type="CTD" id="20318333"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13113">
        <property type="entry name" value="Wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF101">
        <property type="entry name" value="PROTEIN WNT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="576" mass="65790" checksum="6F5451DF8E1399F7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ37</accession>
    <name>A0A074ZQ37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167069.1">
        <property type="nucleotide sequence ID" value="XM_009168805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ37"/>
    <dbReference type="GeneID" id="20327587"/>
    <dbReference type="KEGG" id="ovi:T265_13420"/>
    <dbReference type="CTD" id="20327587"/>
    <dbReference type="OrthoDB" id="5984119at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="24164" checksum="073678CB95B28D0C" modified="2014-10-01" version="1">MRVLGPTFSNPSFLAASINMDMLVAWGKHVTAFTLLSGQYDFTPRPHRIMLTRNTESRCSLSDCSPLTFLAWFQLVERLSSQCSPPDHCSTQAQPPRQSGSFQSGLSQSAGLYQSDLVIFPNTFGSASRFRHIFSMKRAGEMPVTSSATVNSRSSESAKDCRKRKTLRIQYLAESLIEVCRYLDRGEVPQALLQELNIPFQYDWDGNSDMNLYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQJ0</accession>
    <name>A0A074ZQJ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166837.1">
        <property type="nucleotide sequence ID" value="XM_009168573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQJ0"/>
    <dbReference type="STRING" id="6198.A0A074ZQJ0"/>
    <dbReference type="GeneID" id="20318152"/>
    <dbReference type="KEGG" id="ovi:T265_03966"/>
    <dbReference type="CTD" id="20318152"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="922"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122589" checksum="8218E24217CFD4C0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQU9</accession>
    <name>A0A074ZQU9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166518.1">
        <property type="nucleotide sequence ID" value="XM_009168254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQU9"/>
    <dbReference type="STRING" id="6198.A0A074ZQU9"/>
    <dbReference type="GeneID" id="20327472"/>
    <dbReference type="KEGG" id="ovi:T265_13305"/>
    <dbReference type="CTD" id="20327472"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="29802" checksum="D63151489384510E" modified="2014-10-01" version="1" fragment="single">FEEDEFQCKEEDEVSIPRASLNKFIKDVVPDARLTTETRELLLNCCHAFIHKLATQANIACASAKKKTISPEHIFQGLDAMNLSAYKERVVVASEEAKEELKGRRMLSASYRFKHQDSEELERLAREQQEIFEQARADFVGEQLDRGDLLLASELAAADAAALQGPIVGPSADNPTKGMCTNFLAYSSLHPAGDAQTIPKLTGSEHARLGGALSLNVKHHDDCERIVSNIGFTMGIIALLGVPPPLSSTRVKLITPPSDTDGAVLSLIAYCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS61</accession>
    <name>A0A074ZS61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166230.1">
        <property type="nucleotide sequence ID" value="XM_009167966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS61"/>
    <dbReference type="GeneID" id="20317653"/>
    <dbReference type="KEGG" id="ovi:T265_03466"/>
    <dbReference type="CTD" id="20317653"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7185" checksum="31B1EBBBF9504715" modified="2014-10-01" version="1">MIVSRPSVLARLYRTLHHSGAVAPMNQSQQYRVIALEEPTAFKADEVTGDLIIHEGNSDFTFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSF1</accession>
    <name>A0A074ZSF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606922">
        <property type="protein sequence ID" value="KER18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178064.1">
        <property type="nucleotide sequence ID" value="XM_009179800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSF1"/>
    <dbReference type="GeneID" id="20330397"/>
    <dbReference type="KEGG" id="ovi:T265_16232"/>
    <dbReference type="CTD" id="20330397"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="50" mass="5498" checksum="CDCA443B5A81CF8E" modified="2014-10-01" version="1" fragment="single">MDASAQTWWSGRTEVISVQEPLTQPRIFQPADALNPDDEGLGGLIDKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT45</accession>
    <name>A0A074ZT45_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165977.1">
        <property type="nucleotide sequence ID" value="XM_009167713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT45"/>
    <dbReference type="STRING" id="6198.A0A074ZT45"/>
    <dbReference type="GeneID" id="20327363"/>
    <dbReference type="KEGG" id="ovi:T265_13196"/>
    <dbReference type="CTD" id="20327363"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="17046" checksum="9D12E20D5D7DB13F" modified="2014-10-01" version="1" fragment="single">DCPAATPFDRNKLKPILENLRTEWPDFLSAKDPDAFWEHEWYKHGRCAVEDELIKDELGYFNTSLNLHWKLPIMKLLAESGIHPSDSEPLEGEAAKLLEVRICFNPKLEMISCYQQGMNEGEIDINAGRKIEGSMPCPDKLILPQHPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU64</accession>
    <name>A0A074ZU64_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169319.1">
        <property type="nucleotide sequence ID" value="XM_009171055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU64"/>
    <dbReference type="GeneID" id="20320102"/>
    <dbReference type="KEGG" id="ovi:T265_05920"/>
    <dbReference type="CTD" id="20320102"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="221" mass="24773" checksum="521730A9A4F31EA6" modified="2014-10-01" version="1">MVFANSAPDCRAKQGGVRPVAVGQVDQQGPVHLAIQMDQDSLVNLVARSVLDFQADQDPQEVLSNLCVQQVRVYLDGQGLHQFLVGQQTLEVHRPLVLQGHHRAPVLQHPRGLHLVLLVQEFPVVHLDQVVPSRRLDLAVLAGLAHQLNLVDPEVLVRLRDPWGQLLHPPRLVLAVQLVQKFQAVLLYQLVRAYLEDLEFPLNLEDPQGLDVLEHPFCPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUJ0</accession>
    <name>A0A074ZUJ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoma HMGIC fusion partner-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166743.1">
        <property type="nucleotide sequence ID" value="XM_009168479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUJ0"/>
    <dbReference type="GeneID" id="20318074"/>
    <dbReference type="KEGG" id="ovi:T265_03887"/>
    <dbReference type="CTD" id="20318074"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704340" description="Lipoma HMGIC fusion partner-like protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38823" checksum="53C33B7746F56046" modified="2014-10-01" version="1">MRKLWFLWSAIAWISTALCTAGCVLPYWLKGTIYTGINEQLAVAMGLHMTRLPSTLGLYRRCVYPVYTDKMNEALSANQDADSRPGHYVQTTEQARLIRIRAGCGFYQFEQIPHSIWQAALMLLSLACVLLWFISFFLLFVGCYVGLLNYPTLTRACQALLLVSGSLVLACCVLYPLGWSDNPEVTQICGDSSSVFHLGRCQLGWAYLLTLLGGFSSILASALPSLCGPCLTSSHRGFRFCINPSDPTKNATGEVELSRKPQDYIHCSSSSEPNQTMTVHSNVVRWPGAINNFYARVQQPVFVSPGPSPNMPTQSIKSHATNSSLMGSFTEMESKVPTDIKSPTVECCQKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW98</accession>
    <name>A0A074ZW98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597197">
        <property type="protein sequence ID" value="KER19479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176771.1">
        <property type="nucleotide sequence ID" value="XM_009178507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW98"/>
    <dbReference type="STRING" id="6198.A0A074ZW98"/>
    <dbReference type="GeneID" id="20325928"/>
    <dbReference type="KEGG" id="ovi:T265_11760"/>
    <dbReference type="CTD" id="20325928"/>
    <dbReference type="OrthoDB" id="5785174at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="21678" checksum="62F8972345AC4B44" modified="2014-10-01" version="1">MFAVPLEYDNLSGSFVTKVQVGTPPQTFYVVLDTGSPQRWLPSAESNDPIVKSRKRRYRSRTRKPTETIVSVKYASMSVVGRLVEDTLIIGGYTFQDFKFLEVTEMPRAPGKNPMFDGVFGLVLDMTSPEFHPTLLGMMQECDLIEEHSVSFRFCGLLNVAALESIIPALEFTISAVEVETFLLQDTFQQSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW99</accession>
    <name>A0A074ZW99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164802.1">
        <property type="nucleotide sequence ID" value="XM_009166538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW99"/>
    <dbReference type="GeneID" id="20316512"/>
    <dbReference type="KEGG" id="ovi:T265_02324"/>
    <dbReference type="CTD" id="20316512"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9206" checksum="33B8BC8683DCE102" modified="2014-10-01" version="1" fragment="single">WLCIGFPMIYTNINTHAQHHLLHPLLTSCSRTGFPKRTLLSAASLVGLSNQRLKMGYLNQTRPGQPSGIICPHSSVSTDVLPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXC6</accession>
    <name>A0A074ZXC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165705.1">
        <property type="nucleotide sequence ID" value="XM_009167441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXC6"/>
    <dbReference type="STRING" id="6198.A0A074ZXC6"/>
    <dbReference type="GeneID" id="20317239"/>
    <dbReference type="KEGG" id="ovi:T265_03052"/>
    <dbReference type="CTD" id="20317239"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="270"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="355" mass="39380" checksum="923D7AA75AC6D788" modified="2014-10-01" version="1">MAPHKTNVDRKKRKAYYRKSAAACKRQKMASVEDPDRPAQNIPKSLESGMTGYLITCNRKERSAMLESFRLLNDALSKITSSPIIFPPGTQTSDCPRLQYCPKPPQTTPCDGNDEDDDILSELRRENNDTDKPVGSGSSTRFSFYSIRCGVSNCLFLLHLSESASAGDIVHSIFQHLLDTKEPQSRYVLRLLPVAATCQANCVEIKQCIRKLWAAFLGTVSVNTATPVTVTQAPDTSDAAGIEVTNNSSSPDPSPSVHRLCPNVPPQRAKEQTMKGPKTFLVMFKARNYNLLSRDNAIEATVSAVQSVDSSWRINPNTPSVIIYVNVLRTVACISLLENFDLYRKYNVSELLTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXC7</accession>
    <name>A0A074ZXC7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168228.1">
        <property type="nucleotide sequence ID" value="XM_009169964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXC7"/>
    <dbReference type="GeneID" id="20319235"/>
    <dbReference type="KEGG" id="ovi:T265_05053"/>
    <dbReference type="CTD" id="20319235"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="14200" checksum="A69B86513248A290" modified="2014-10-01" version="1">MLTHHNAEPTYTVPSPTSRAARTHSAHTRDTRHGKPTVSRSGVYHAPYNDKAERTQTKAVGPDPKIRRGKEVLAVWIPSRSTFNRGNSTQSTKTSWGLSGLYELLNHGPPAFADSTMVEPPRALERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXF5</accession>
    <name>A0A074ZXF5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165605.1">
        <property type="nucleotide sequence ID" value="XM_009167341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXF5"/>
    <dbReference type="GeneID" id="20317150"/>
    <dbReference type="KEGG" id="ovi:T265_02962"/>
    <dbReference type="CTD" id="20317150"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="257" mass="29507" checksum="48A5915D0EE69F0C" modified="2014-10-01" version="1">MELDAKGIPGLVFVVSCEPPLERPIKLSWYRDRCNQNFEQYRINERHNTEATGSQEMSKRKKHRKKCGQLYIRGHFLSVVYGIASCISLPRRAKHQRQQTEVSSTFFDFLNLKARLRTIGDGRCTRATGEVAGIRLPNVLAALAFIAAVAHTDCFAGVLKIAEIWLAEINITQTLRHCCLRATRMILDPDGIYPNTSDGLLIDWENVKRVEKLRRIKINYIADEPMGEKAPRLNRARQKEQRNLSEMVKKVQLFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYB4</accession>
    <name>A0A074ZYB4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167941.1">
        <property type="nucleotide sequence ID" value="XM_009169677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYB4"/>
    <dbReference type="GeneID" id="20319013"/>
    <dbReference type="KEGG" id="ovi:T265_04831"/>
    <dbReference type="CTD" id="20319013"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17392" checksum="7F082D5D8DE0E17C" modified="2014-10-01" version="1">METARGGQSVAWQRSMYVLISQLSCVGDRSLPGWKPRDNTNPWLVTLADIVVTQPVTVFHQSYHLVPYFKHRSVCRHCSDWAIASNELGQTDGIPALVLPSGGMAVRYLESVTDERFFRRLSLLVVDQVAVDLFAELSNWLANVSSPVEETSSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYG9</accession>
    <name>A0A074ZYG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163752.1">
        <property type="nucleotide sequence ID" value="XM_009165488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYG9"/>
    <dbReference type="STRING" id="6198.A0A074ZYG9"/>
    <dbReference type="GeneID" id="20326956"/>
    <dbReference type="KEGG" id="ovi:T265_12788"/>
    <dbReference type="CTD" id="20326956"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25039" checksum="F0D12EFAA662FD31" modified="2014-10-01" version="1" fragment="single">SALLFHLNRYCEQHSIVIRRGHPQISRNQSLSLDARLQCPPLKQAGQQAALALTLDSLGIDVCCASETRTQDARTVAEIIAPLLCRPENVQWLMSPYRSAVTPFRCLAAMPHEGSTRTGILPGCPSLDRGSREADVGFEPRTFRSVNSRSNHLVHLTPGIILSHKAKIFLLDWIPVDVRDSSGNCYEEVLQGVLNCLCPLTFLPTDCSYDTTNDKFYDTLNALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYM8</accession>
    <name>A0A074ZYM8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_01440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163730.1">
        <property type="nucleotide sequence ID" value="XM_009165466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYM8"/>
    <dbReference type="STRING" id="6198.A0A074ZYM8"/>
    <dbReference type="GeneID" id="20315628"/>
    <dbReference type="KEGG" id="ovi:T265_01440"/>
    <dbReference type="CTD" id="20315628"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="43629" checksum="288D47500D302C84" modified="2014-10-01" version="1">MNFPHDQMQGLACRHYFCLACWQRYLEWKIMEESQGDRIYCPSYGCNVLIEDESVFRVITNPNVRRRFQKLISNSFVMHNRSLTWCPGADCGYAARCLGPEEPRQINCTNCSESFCFACSQPWHDPVRCDQLKNWLKRVSDDSGTSNWIVANTKECPKCHATIEKSGGCNHMICRNVDCKFEFCWLCLDRWEPHGAGWYKCNRYNEDTAKKARDAQAQSRRNLDRYLFYFNRYFSHLQSLRFEARLYESVQEKMDAMQNSGTSWIDVKFIRKVVDVLCSCRRTLMYTYVFAFFLKKNNHSILFERNQSDLELSTEYLSGLLDRDLCTTSLNELKQKLQDKARYCASRRRVLLEHVDEGYKEGIWEPYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ92</accession>
    <name>A0A074ZZ92_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163490.1">
        <property type="nucleotide sequence ID" value="XM_009165226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ92"/>
    <dbReference type="GeneID" id="20315429"/>
    <dbReference type="KEGG" id="ovi:T265_01241"/>
    <dbReference type="CTD" id="20315429"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8156" checksum="87BC0E2794C0780E" modified="2014-10-01" version="1">MPNSEWRKQRGGQPMTWQRSMKEIARRLGAVGATRLPGWGPRDPHCAWLETLQDMAANRYYAPLQMASNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZD9</accession>
    <name>A0A074ZZD9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163340.1">
        <property type="nucleotide sequence ID" value="XM_009165076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZD9"/>
    <dbReference type="GeneID" id="20315303"/>
    <dbReference type="KEGG" id="ovi:T265_01115"/>
    <dbReference type="CTD" id="20315303"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="180" mass="20393" checksum="5E1E5E4EFFC30E6B" modified="2014-10-01" version="1">MPAGCPFTHSGMGQFREIHKAFVAFGRVNSLPEYYGPKVKNDLKITPKQKPTIVGMFIVSMNEENPFYEKPTVGNLAILSTERQSKLGNSTFSILRAPRSVAQWAADHDSETPIKHIERLVQIYLATLNIDYEIRSWLDPPFESTSEHSTAAQNYGYMDSCRERIEVPNIYALCLPKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZG0</accession>
    <name>A0A074ZZG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597042">
        <property type="protein sequence ID" value="KER20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175690.1">
        <property type="nucleotide sequence ID" value="XM_009177426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZG0"/>
    <dbReference type="GeneID" id="20325080"/>
    <dbReference type="KEGG" id="ovi:T265_10912"/>
    <dbReference type="CTD" id="20325080"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="41" mass="4522" checksum="34D19193C4EE5DBF" modified="2014-10-01" version="1" fragment="single">DTPMYLGIRRIDVLGNPNAELGEQTNNQAAHPSHLYSTTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Q0</accession>
    <name>A0A075A0Q0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162918.1">
        <property type="nucleotide sequence ID" value="XM_009164654.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A0Q0"/>
    <dbReference type="GeneID" id="20314970"/>
    <dbReference type="KEGG" id="ovi:T265_00782"/>
    <dbReference type="CTD" id="20314970"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1583" mass="175752" checksum="CBE82F8C4133EFFC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0U6</accession>
    <name>A0A075A0U6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167084.1">
        <property type="nucleotide sequence ID" value="XM_009168820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0U6"/>
    <dbReference type="STRING" id="6198.A0A075A0U6"/>
    <dbReference type="GeneID" id="20318336"/>
    <dbReference type="KEGG" id="ovi:T265_04150"/>
    <dbReference type="CTD" id="20318336"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11845" checksum="4A785A38602D4ADB" modified="2014-10-01" version="1">MFNRKSGKRVKAHTDIVRFDRRLIVFDTSGAMEELLPIIKLVHNAHNGIISCLTTARVSNAVFLLLSGGFDRIVKIWDEEGQHLHTICSFTQPVLAWLLETRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A144</accession>
    <name>A0A075A144_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162865.1">
        <property type="nucleotide sequence ID" value="XM_009164601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A144"/>
    <dbReference type="STRING" id="6198.A0A075A144"/>
    <dbReference type="GeneID" id="20314940"/>
    <dbReference type="KEGG" id="ovi:T265_00752"/>
    <dbReference type="CTD" id="20314940"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704440" description="MRG domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="8">
        <location>
            <begin position="215"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="410" mass="47331" checksum="41D20C2C08B05DC5" modified="2014-10-01" version="1">MNLVCVAFALLRSSLLGEKLLCFHGPLLYEAKVTFDCIYPFFLVHNAVGTKSQFSFHRDRSLHFNNSWDEWVTDKRIFKYNEEGLRKQKELEQQIKSGKKVKILRKSDLKKQSYPPPEIMEEIEQTLRPVENKQQEVNQPEPKVKVKPSDELSSLSEQPKQSTNTTPPPEPAPISSNKPSEPPKPPLQEEHVPPASHTPVSNRRRKGRTGPHDGSIENEEGFLTAPQLKVDLPSSLKAWLVDDWDLITRQARLYELPAPYPISSIMLDFLQYANTNDVKPEPSENMPAPQCKLPITSDLRHEFIAGLQHYFNQVVGSQLLYKFERLQYAELLKQHTDKRMSDIYGSIHLLRLFVKLREMVSCTRVDPSGLPVLETLVNEFLEFLRAKQKTYFRLENYTVATAEYQRRAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1C0</accession>
    <name>A0A075A1C0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162735.1">
        <property type="nucleotide sequence ID" value="XM_009164471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1C0"/>
    <dbReference type="GeneID" id="20314831"/>
    <dbReference type="KEGG" id="ovi:T265_00643"/>
    <dbReference type="CTD" id="20314831"/>
    <dbReference type="OrthoDB" id="6227326at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="497" mass="57733" checksum="83CFC292AE5426CB" modified="2014-10-01" version="1">MGHLGEQAHRRRNQVLMRQDCTALIGVAMALVLHTMALLADAENFVPIKNRSILFKEHKIREAQQPTGKQQANGGFWFNKGHPNAHCFQAPEGLDCKSVLQNQASAEKALNNWKLDYRQLLSRITCTLQKLSCPLEGRSLQLHDIPCQSSCLEFLESCEKSRSLEGQYNNPVSAIPAGCPVEKRRVPLDAPSWSHSQKNQMYSSRASSPNAHRFPYGSTFYARRYSTYRNQPSSLSPRDVRPYPQTHQATPTFDSGYWKPRYQRRVSSFRSQEHSRGHESSDQLSFEQYTYPSRHEENKGDLELTRAACSLLPTGGCEKWPDYWGLQNQDSSPVQQKIQVNPGCPSDLSKMCEAMFPREFTRHHWIRGEYTVASVIRISQTLWWFGENDLFQPFFRFHVLETLESDIHPYDDKMILTYSWPIRCVCPDELTVNKRYLMLTHSYKARQTLNITANTVFLSRIKRYTKRLACWKGACVRSNRRNRRRRYPNSHWRWGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I5</accession>
    <name>A0A075A1I5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596981">
        <property type="protein sequence ID" value="KER21249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174997.1">
        <property type="nucleotide sequence ID" value="XM_009176733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I5"/>
    <dbReference type="STRING" id="6198.A0A075A1I5"/>
    <dbReference type="GeneID" id="20324545"/>
    <dbReference type="KEGG" id="ovi:T265_10377"/>
    <dbReference type="CTD" id="20324545"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="317" mass="33975" checksum="1092E65FA13380AA" modified="2014-10-01" version="1">MSGVRSSNPGTAIGYGLLMSSNKSETRVQPVEYNDRTLARALAYQKSLKANMGGTLVLPALKAAYDAPLTGKDWYRQILFVTDGYVTNANEVIGLAASNVHKAKLFPIGIRLDSGKHLLMSLARAGQGTAAFVQDDSKLRGVLMKILGAALQPRAGDIKVQWELRSKNNGSAVTPLQVLTIPECIPAVFHGKFITVYGLIPAGSSVGLSGTVSLQCNVLGEKQLFKVELSKVAKEAEFSSEEVPLHRLAGKCQLNELGDRYKAERMSNKSPEDPEIVKLRGAIEKISCAINILSPVTAMVGVDPVKRGKSSSCTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A254</accession>
    <name>A0A075A254_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_12816</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163941.1">
        <property type="nucleotide sequence ID" value="XM_009165677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A254"/>
    <dbReference type="STRING" id="6198.A0A075A254"/>
    <dbReference type="GeneID" id="20326984"/>
    <dbReference type="KEGG" id="ovi:T265_12816"/>
    <dbReference type="CTD" id="20326984"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="236"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="445"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="645" mass="71743" checksum="DE4B85BC3E6A9325" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2S5</accession>
    <name>A0A075A2S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163721.1">
        <property type="nucleotide sequence ID" value="XM_009165457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2S5"/>
    <dbReference type="GeneID" id="20315619"/>
    <dbReference type="KEGG" id="ovi:T265_01431"/>
    <dbReference type="CTD" id="20315619"/>
    <dbReference type="OrthoDB" id="6142323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="18762" checksum="0DD94BB8869EFB0F" modified="2014-10-01" version="1">MGRTLRRAVQLASCNTASGDDAYGRMESALKREKAPGPDGLYPALFREGGKFLVSHLTKLIGTIWDEEANELVRLASVLAKTSVRQPQALRKQSSKHDEQQFSWSPAASNPESWPSIERWAVGMDPPSVSGVSECTTLLKHHHAAGPDDLPPALFKDGGGLLSQCRSSRFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3X3</accession>
    <name>A0A075A3X3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_03305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166015.1">
        <property type="nucleotide sequence ID" value="XM_009167751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3X3"/>
    <dbReference type="GeneID" id="20317492"/>
    <dbReference type="KEGG" id="ovi:T265_03305"/>
    <dbReference type="CTD" id="20317492"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="142"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="305"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="451"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="560"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="697"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="814"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1261"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER30255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1271" mass="141681" checksum="AB987BA1F34C9BC6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4G5</accession>
    <name>A0A075A4G5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162028.1">
        <property type="nucleotide sequence ID" value="XM_009163764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4G5"/>
    <dbReference type="STRING" id="6198.A0A075A4G5"/>
    <dbReference type="GeneID" id="20314295"/>
    <dbReference type="KEGG" id="ovi:T265_00107"/>
    <dbReference type="CTD" id="20314295"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="26983" checksum="C51E168C34129511" modified="2014-10-01" version="1">MDEPQVPMTEFEQIKFRMNQTTDELPPCNDDEIRLEDGTVRPMTEVELLHKRIDDATAESLEASRRMMAMCEEAKEAGISTLVMLDDQGEQLDRINEGMDQINQDMKDAEKNLDDLNKCCGLCVLPWNKVKKKDDYTKQLKDEDMRGGGDGPRIIVDQNGMGPTGGYITRITNDAREDEMDNNLQEVSGMIGNLRNMAIDMGSEINQQNVQIERIQIKAKSNAERIKKANEQASKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4M0</accession>
    <name>A0A075A4M0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163106.1">
        <property type="nucleotide sequence ID" value="XM_009164842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4M0"/>
    <dbReference type="STRING" id="6198.A0A075A4M0"/>
    <dbReference type="GeneID" id="20326828"/>
    <dbReference type="KEGG" id="ovi:T265_12660"/>
    <dbReference type="CTD" id="20326828"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="6">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="766" mass="86333" checksum="6CDF94CEFB228454" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4M3</accession>
    <name>A0A075A4M3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596903">
        <property type="protein sequence ID" value="KER22364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173896.1">
        <property type="nucleotide sequence ID" value="XM_009175632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4M3"/>
    <dbReference type="STRING" id="6198.A0A075A4M3"/>
    <dbReference type="GeneID" id="20323702"/>
    <dbReference type="KEGG" id="ovi:T265_09533"/>
    <dbReference type="CTD" id="20323702"/>
    <dbReference type="OrthoDB" id="6061248at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF66">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER22364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="283" mass="31997" checksum="28CF0A292FC49178" modified="2014-10-01" version="1">MRGIYSLGRHNKLHRMVQRSRINRSSSGKMPFDCTGILLSFLFLQNLAVAQNHPVSYEAGSIEVRRQRDEIVSLQSAPTSNATATPHSPEEYGIPCEQNATSEHASKPTGRGDRNNAHQCLVCGKTFQYRTLLMRHQKSHNDHHDFQCDLCSNAYKHPADLRRHMKAKHPSEFTGPYRVSSEQVLKSLRAGNPCSECNKSFRSWKGLRRHQKIIHEGQDRSVCEECGKTFSQKDGLRKHVQTVHSKLGCFTCAQCGKSLSSSFALRKHINSMHESVPKDESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4S2</accession>
    <name>A0A075A4S2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Eukaryotic translation initiation factor 4 gamma 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_00778</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. Interacts with DAZAP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162914.1">
        <property type="nucleotide sequence ID" value="XM_009164650.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A4S2"/>
    <dbReference type="GeneID" id="20314966"/>
    <dbReference type="KEGG" id="ovi:T265_00778"/>
    <dbReference type="CTD" id="20314966"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="W2" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="837"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1316"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1358" mass="150059" checksum="1052CAF5DD5FA0D4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A517</accession>
    <name>A0A075A517_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596894">
        <property type="protein sequence ID" value="KER22524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173734.1">
        <property type="nucleotide sequence ID" value="XM_009175470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A517"/>
    <dbReference type="STRING" id="6198.A0A075A517"/>
    <dbReference type="GeneID" id="20323586"/>
    <dbReference type="KEGG" id="ovi:T265_09417"/>
    <dbReference type="CTD" id="20323586"/>
    <dbReference type="OrthoDB" id="568502at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="641" mass="72543" checksum="D9F8BA5990EBAD02" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5P3</accession>
    <name>A0A075A5P3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="6198.A0A075A5P3"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="271" mass="29802" checksum="420D2B7079F1D21E" modified="2014-10-01" version="1">MGQEARRCMVHTMRTFLVAYNVVFLHYKTEYEIQLTGIGLATVGFLMCTQYRGYTKSLGPDLSIIPMLLAVLGIMIIFASSLGILGALLSHSCLLVCYSGILLLLLLGEIALGCAAFTEQDEVEHKAEVGIVQIMAQYMRTNETRFGVDYVQRKFNCCGVTGYRDWQHVLGSTVVPESCCSDPEHCVRQYEDLPNGSVPPGVQTRPSRRGFEETAVSSLSLSSAAVRCNFWESSSAFCWPTDSEAPPAENFSTAHNRFRPSASGSSGRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9S5</accession>
    <name>A0A075A9S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163678.1">
        <property type="nucleotide sequence ID" value="XM_009165414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9S5"/>
    <dbReference type="GeneID" id="20315576"/>
    <dbReference type="KEGG" id="ovi:T265_01388"/>
    <dbReference type="CTD" id="20315576"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="217" mass="24469" checksum="A73F334D0B247CEE" modified="2014-10-01" version="1">MNRSAVIPFRHPAAESTRTGILPVCSRLDRGTQDAEVGFEPRTFQSVNSRSNHWAILCHLLCVNPMEGRRAFILIFEVSAVWEKFRGVGTRGNKSPFHIDVEHLQMVIPKQSTGMQMSKLKHTTCSTLLGLESTGMLHVIIIIIDSMTSVFNTDASLPYNHDLFESLIAKKRMKIFTQAIWTETENKNAIDIGWQPYLVVSPTRHSEDHAVPILEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADM0</accession>
    <name>A0A075ADM0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_00157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162078.1">
        <property type="nucleotide sequence ID" value="XM_009163814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADM0"/>
    <dbReference type="STRING" id="6198.A0A075ADM0"/>
    <dbReference type="GeneID" id="20314345"/>
    <dbReference type="KEGG" id="ovi:T265_00157"/>
    <dbReference type="CTD" id="20314345"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF49">
        <property type="entry name" value="PAIRED BOX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Paired" evidence="13">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="639"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="102414" checksum="CCF6BACC5494C9F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEX9</accession>
    <name>A0A075AEX9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_05709</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169046.1">
        <property type="nucleotide sequence ID" value="XM_009170782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEX9"/>
    <dbReference type="STRING" id="6198.A0A075AEX9"/>
    <dbReference type="GeneID" id="20319891"/>
    <dbReference type="KEGG" id="ovi:T265_05709"/>
    <dbReference type="CTD" id="20319891"/>
    <dbReference type="OrthoDB" id="6101876at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER27174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19128" checksum="85C347F41319DDA4" modified="2014-10-01" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGVFDAKFSRVTRHNLVDLIVRSKGRVVYPWPDGSHAHKRSPRALAENSNTPRTELNLSIDGYACGSNRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG85</accession>
    <name>A0A075AG85_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167788.1">
        <property type="nucleotide sequence ID" value="XM_009169524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG85"/>
    <dbReference type="GeneID" id="20318902"/>
    <dbReference type="KEGG" id="ovi:T265_04720"/>
    <dbReference type="CTD" id="20318902"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704597" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="137" mass="15593" checksum="9AA90F70F66C86D7" modified="2014-10-01" version="1">MGRYAVGMRASRCLALCSFLMCIATNTTSYESANLLTTGSWFEPDIVYSRPHSVKKDPLVEEVELVNCNPQYAAFLSLAERKKPFLLCIWHPDHKISQGKFMVVRVAAPQDETHSRLILLGAKRPYQNNSVKFQRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGJ1</accession>
    <name>A0A075AGJ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167474.1">
        <property type="nucleotide sequence ID" value="XM_009169210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGJ1"/>
    <dbReference type="STRING" id="6198.A0A075AGJ1"/>
    <dbReference type="GeneID" id="20318643"/>
    <dbReference type="KEGG" id="ovi:T265_04461"/>
    <dbReference type="CTD" id="20318643"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="520" mass="58470" checksum="21F9F38962BF2E48" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHD2</accession>
    <name>A0A075AHD2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166596.1">
        <property type="nucleotide sequence ID" value="XM_009168332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHD2"/>
    <dbReference type="GeneID" id="20317966"/>
    <dbReference type="KEGG" id="ovi:T265_03779"/>
    <dbReference type="CTD" id="20317966"/>
    <dbReference type="OrthoDB" id="6267986at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11258" checksum="44721152956CD387" modified="2014-10-01" version="1">MASPHLGSYIPRFHMEKKSVLDTTENQRCGPHPIDLYLTELLTQMEQNGSNSLSDKLAYDQILVAFTAMHDYHPVYYLRMLRAIRDWNRCRASSGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHF3</accession>
    <name>A0A075AHF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166499.1">
        <property type="nucleotide sequence ID" value="XM_009168235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHF3"/>
    <dbReference type="GeneID" id="20317880"/>
    <dbReference type="KEGG" id="ovi:T265_03693"/>
    <dbReference type="CTD" id="20317880"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12904" checksum="C47B1156F5A18BBB" modified="2014-10-01" version="1">MTLKKSSSCSILPVSSCHATRRRQEGWDTAGSHRSRQGKSSGGGRVRTTDLPVATRGTRTVEKKQHIFGLLSKAYLLYCSTKLSQIVWTVMAKTPFSWASGHVENERIRVEDTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHL1</accession>
    <name>A0A075AHL1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the MCM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166218.1">
        <property type="nucleotide sequence ID" value="XM_009167954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHL1"/>
    <dbReference type="STRING" id="6198.A0A075AHL1"/>
    <dbReference type="GeneID" id="20327420"/>
    <dbReference type="KEGG" id="ovi:T265_13253"/>
    <dbReference type="CTD" id="20327420"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004169">
        <property type="entry name" value="Atlastin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="8">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="8">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="7">
        <location>
            <begin position="356"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83824" checksum="8B776A19282DF717" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIA5</accession>
    <name>A0A075AIA5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164989.1">
        <property type="nucleotide sequence ID" value="XM_009166725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIA5"/>
    <dbReference type="GeneID" id="20316664"/>
    <dbReference type="KEGG" id="ovi:T265_02476"/>
    <dbReference type="CTD" id="20316664"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="8673" checksum="9927FFEB916190E1" modified="2014-10-01" version="1">MKDDALRVSPQAGLSNLCGTTGCPQLPVAPPDLLVVTNGLSTGEIGTCQTTLVSSLKICPESADEKTVKLAYLTNRVARSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIE4</accession>
    <name>A0A075AIE4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164730.1">
        <property type="nucleotide sequence ID" value="XM_009166466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIE4"/>
    <dbReference type="STRING" id="6198.A0A075AIE4"/>
    <dbReference type="GeneID" id="20316450"/>
    <dbReference type="KEGG" id="ovi:T265_02262"/>
    <dbReference type="CTD" id="20316450"/>
    <dbReference type="OrthoDB" id="412793at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705493" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68189" checksum="49700E453D4D874F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIG8</accession>
    <name>A0A075AIG8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596644">
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        <source>
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        <source>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
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                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Sternberg P.W."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KER32789.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="OrthoDB" id="2428204at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKFN1"/>
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        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1723" mass="192268" checksum="693CA5E5889714C8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJA5</accession>
    <name>A0A075AJA5_OPIVI</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="5 6">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Hall R.S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_009164721.1">
        <property type="nucleotide sequence ID" value="XM_009166457.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177725.1">
        <property type="nucleotide sequence ID" value="XM_009179461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV01"/>
    <dbReference type="GeneID" id="20316441"/>
    <dbReference type="GeneID" id="20326408"/>
    <dbReference type="KEGG" id="ovi:T265_02253"/>
    <dbReference type="KEGG" id="ovi:T265_12240"/>
    <dbReference type="CTD" id="20316441"/>
    <dbReference type="CTD" id="20326408"/>
    <dbReference type="OrthoDB" id="6266384at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007375740" evidence="2">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="287" mass="32339" checksum="873475A27CDA2FC3" modified="2014-10-01" version="1">MNFQLSCAIFLTSVCAAQLVRPPVWNFNQPFGGPQHPAFLDGAWMEVGAPNGPSPFPFNSPNAVQPGRPEFASSQPQEYKVLRGVDGTSVFSLPKTKATSTDDDSTVEEILRLFDKLDPIPEQYQSPIFPPTPGFPPLLNQYPFIRSPLGFLPGFPYTLPPGFFPGNPLWSRDYRMFGGTLFPPFFPPIYPLPPVQKRSKSNSPRTIFSYLLGTNGMLPGGKDSKENRVPVRYMTGGQRKRSGDVSKRSNNKKWFQRDKKNKPGEQQRSSKSDRIRFERISPRLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ44</accession>
    <name>A0A074YZ44_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03499</name>
        <name evidence="2" type="ORF">T265_12260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600754">
        <property type="protein sequence ID" value="KER18482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166263.1">
        <property type="nucleotide sequence ID" value="XM_009167999.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177771.1">
        <property type="nucleotide sequence ID" value="XM_009179507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ44"/>
    <dbReference type="STRING" id="6198.A0A074YZ44"/>
    <dbReference type="GeneID" id="20317686"/>
    <dbReference type="GeneID" id="20326428"/>
    <dbReference type="KEGG" id="ovi:T265_03499"/>
    <dbReference type="KEGG" id="ovi:T265_12260"/>
    <dbReference type="CTD" id="20317686"/>
    <dbReference type="CTD" id="20326428"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989">
        <property type="entry name" value="USP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46989:SF3">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17484" checksum="A363DB80B95E46A0" modified="2014-10-01" version="1">MVSPKARRILFPIDRSDHSKRAIQWYLDKFAWENDALYLVHVVEPNYSRRFSEVSPDDHTSALTNKMKESVAAGEQVGAQYRSFLKERGKESEFVMQVGTKPGEQIINAARDVSADVIIIGNRGVGTIRRTVLGSVSDYVFHHSSIPVILVPPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZX9</accession>
    <name>A0A074YZX9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_15337</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175902.1">
        <property type="nucleotide sequence ID" value="XM_009177638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZX9"/>
    <dbReference type="STRING" id="6198.A0A074YZX9"/>
    <dbReference type="GeneID" id="20329502"/>
    <dbReference type="KEGG" id="ovi:T265_15337"/>
    <dbReference type="CTD" id="20329502"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="19">
        <location>
            <begin position="35"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="18">
        <location>
            <begin position="231"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER20346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="707" mass="81235" checksum="73B3B94090F0E17B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0D8</accession>
    <name>A0A074Z0D8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597049">
        <property type="protein sequence ID" value="KER20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175742.1">
        <property type="nucleotide sequence ID" value="XM_009177478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0D8"/>
    <dbReference type="GeneID" id="20325124"/>
    <dbReference type="KEGG" id="ovi:T265_10956"/>
    <dbReference type="CTD" id="20325124"/>
    <dbReference type="OrthoDB" id="6229273at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="12684" checksum="2C6F3C7B32BC506D" modified="2014-10-01" version="1">MVQIPISSTGHSNLRTNDGIKRESNAPELLLYLTAMPNGDTPSPGDGLILCLVKLGLLLVHVASNFPPTASLFAVSQFVESSLLLGQLNIASALVLPSSAMTFRHRKNLTGVFVLCVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2K0</accession>
    <name>A0A074Z2K0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mTERF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175072.1">
        <property type="nucleotide sequence ID" value="XM_009176808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2K0"/>
    <dbReference type="STRING" id="6198.A0A074Z2K0"/>
    <dbReference type="GeneID" id="20324604"/>
    <dbReference type="KEGG" id="ovi:T265_10436"/>
    <dbReference type="CTD" id="20324604"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33936" checksum="07B7A4006B05DCB7" modified="2014-10-01" version="1">MVRLGVDLSKLESVPGAANMLVKLDFHQSIEPVIWKLHGHGFSLEQIARLFTVFPKVLQLSSEEIDTRIGYFLQHNFVQADVVQMFFKHPTILELSPVDVDRQLASIQTVFQLSADELRKSVVAVPKLILHPLGKTKDIYVVLSKMMGFSNEAVRQMVCQNATLLVTERDRLAQNFMFMHSRLNLPLERIQQWSTVLSSAPHLLSQRATFLVRRGLFQPDPTKPLYTPLSEVVNGDDAQFCERFGLVDEDQYNCLAAIPPRESTSAGILSCCPSLDRGSREAETTFELRTLRSINSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4W8</accession>
    <name>A0A074Z4W8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174112.1">
        <property type="nucleotide sequence ID" value="XM_009175848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4W8"/>
    <dbReference type="GeneID" id="20323860"/>
    <dbReference type="KEGG" id="ovi:T265_09692"/>
    <dbReference type="CTD" id="20323860"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10073" checksum="AF2E8119F666EB72" modified="2014-10-01" version="1">MVEAEYVWKPIFAGLDGCGGWELGLLAAGRLFGYTVEIVDGGSGSGNRLEDERRERCHNEILLIYVIHKVNNFCTVCSGLCDYTNSSKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4Y6</accession>
    <name>A0A074Z4Y6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_09693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174113.1">
        <property type="nucleotide sequence ID" value="XM_009175849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4Y6"/>
    <dbReference type="GeneID" id="20323861"/>
    <dbReference type="KEGG" id="ovi:T265_09693"/>
    <dbReference type="CTD" id="20323861"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF65">
        <property type="entry name" value="BESTROPHIN 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="13">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER22123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="690" mass="76937" checksum="B8BFBD0295DA3946" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5K3</accession>
    <name>A0A074Z5K3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein-serine/threonine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09490</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the RPAP2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175572.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074Z5K3"/>
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    <dbReference type="KEGG" id="ovi:T265_09490"/>
    <dbReference type="CTD" id="20323659"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
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    </dbReference>
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        <property type="entry name" value="DnaJ"/>
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    </dbReference>
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        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
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    </dbReference>
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        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="242"/>
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        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="RTR1-type" evidence="10">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER22411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="109702" checksum="CCC46887D6E0A3EF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7F3</accession>
    <name>A0A074Z7F3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597320">
        <property type="protein sequence ID" value="KER19130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177124.1">
        <property type="nucleotide sequence ID" value="XM_009178860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7F3"/>
    <dbReference type="GeneID" id="20329814"/>
    <dbReference type="KEGG" id="ovi:T265_15649"/>
    <dbReference type="CTD" id="20329814"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10732" checksum="349C4379C9F1EDEC" modified="2014-10-01" version="1" fragment="single">MFEVIAGAELTLNDFERLPPECCQPSPSLPRFHGTGHIAPPSQAFRMHTLSLTPADKTGKPNAREHQGINLYGFPSPHISKLSSHSFIFHKISKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7J6</accession>
    <name>A0A074Z7J6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173109.1">
        <property type="nucleotide sequence ID" value="XM_009174845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7J6"/>
    <dbReference type="GeneID" id="20323093"/>
    <dbReference type="KEGG" id="ovi:T265_08914"/>
    <dbReference type="CTD" id="20323093"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14219" checksum="C325518A3C895670" modified="2014-10-01" version="1">MCCRREMSSKVYDSSDLYIQPYSDDICESRNLVINNGSADFIRSNYLFDNASFETRPSKKIGSLFNVGGRKNGVRSTVVWGKTNSQVGAFSIARVTVVIMLHGANVTIHPLKDPISRTMLLAAKPSGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7K8</accession>
    <name>A0A074Z7K8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173168.1">
        <property type="nucleotide sequence ID" value="XM_009174904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7K8"/>
    <dbReference type="GeneID" id="20328878"/>
    <dbReference type="KEGG" id="ovi:T265_14712"/>
    <dbReference type="CTD" id="20328878"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16866" checksum="8F08AACB81194EE7" modified="2014-10-01" version="1" fragment="single">MGCDLSKVYNVDIHLENELAVFEPRDEVAGHVIIQAEEDTVIDIQLQGRNTPPGPTGAIIHPRVALHLLWRRQYSKHTQLYPDKQGTFGKIFLGNAPICKARAAFANLRHLWRQNGLSLNLKGRVYQTTVRAVLLYGCETWPIRAADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L7</accession>
    <name>A0A074Z7L7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterodimer with PSMG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596956">
        <property type="protein sequence ID" value="KER21582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174659.1">
        <property type="nucleotide sequence ID" value="XM_009176395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L7"/>
    <dbReference type="STRING" id="6198.A0A074Z7L7"/>
    <dbReference type="GeneID" id="20324287"/>
    <dbReference type="KEGG" id="ovi:T265_10119"/>
    <dbReference type="CTD" id="20324287"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="282" mass="31221" checksum="97C45A2F4149D76A" modified="2014-10-01" version="1">MSHVVTIYRSKSSDLVCNAPSEWKDFTVFVACVGVGNVGQLACDLLIHNLNCVLAGSLDFACLPAVVGPDPFSSSPKEDSLLTCSQIYTNNGRRIAILQIRAPPFSKCQGKHTEELAQFLFKAQFSRVILLSSSFAMQRKDAELMASPLRYAITENFNIADVQRLKSKQWPVLLEHTEDLEDDLPASKRRARPTYRLLGCGIASRLFDRLSKGPEGQLPVCLLNIFASEGDNAGDALYMVHQLSDWLVLLDNSSADKTPHEVWLPPPSWSLLYGTSALESLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7M1</accession>
    <name>A0A074Z7M1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173095.1">
        <property type="nucleotide sequence ID" value="XM_009174831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7M1"/>
    <dbReference type="STRING" id="6198.A0A074Z7M1"/>
    <dbReference type="GeneID" id="20323082"/>
    <dbReference type="KEGG" id="ovi:T265_08903"/>
    <dbReference type="CTD" id="20323082"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000060">
        <property type="entry name" value="F-box/LRR-repeat protein 20 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF165">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN FBXL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="179"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="396"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="564" mass="62226" checksum="D13F6CC74B4AF29D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Q7</accession>
    <name>A0A074Z7Q7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173139.1">
        <property type="nucleotide sequence ID" value="XM_009174875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Q7"/>
    <dbReference type="GeneID" id="20323115"/>
    <dbReference type="KEGG" id="ovi:T265_08936"/>
    <dbReference type="CTD" id="20323115"/>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704956" description="acid phosphatase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="866" mass="98463" checksum="87F57E7E5A814A4F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z974</accession>
    <name>A0A074Z974_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_11520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176462.1">
        <property type="nucleotide sequence ID" value="XM_009178198.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z974"/>
    <dbReference type="GeneID" id="20325688"/>
    <dbReference type="KEGG" id="ovi:T265_11520"/>
    <dbReference type="CTD" id="20325688"/>
    <dbReference type="OrthoDB" id="6269389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1266"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1357"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="606"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1468"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="905"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1460"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1751"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2009"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2070"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2246"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2316"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2486"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2554"/>
            <end position="2603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2691"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2832"/>
            <end position="2876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2985"/>
            <end position="3051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2105"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2126"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2254"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2326"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2560"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2702"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2740"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2864"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3001"/>
            <end position="3014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER19785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3148" mass="341973" checksum="27D931FE7DEAF2ED" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAK5</accession>
    <name>A0A074ZAK5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 153</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172102.1">
        <property type="nucleotide sequence ID" value="XM_009173838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAK5"/>
    <dbReference type="STRING" id="6198.A0A074ZAK5"/>
    <dbReference type="GeneID" id="20322304"/>
    <dbReference type="KEGG" id="ovi:T265_08125"/>
    <dbReference type="CTD" id="20322304"/>
    <dbReference type="OrthoDB" id="6239076at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28610" checksum="DB6891DF9F59797B" modified="2014-10-01" version="1">MPHEQLPPMEPERRYLRIHDSPTEPTTSKPLERELLYGTRRMSKKVGPKKKGRGSKSKSDPTEEALEKAQKDVRAFRDQLSRTVLLAETAESRRQTAIQEKIKTAKELEEVRHTTQQHTAFMVTQNEMIVSSLNNKIEKLEESLQKLNEMVKEKDDALEQLKLEFSETLTERDLKIDRLKMQLSTLGVMCEDAMLQAVEKLTNKLSEDYQLIHNNYMPWSQKTLEKIELEFLNPPFLDAQSTEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAQ8</accession>
    <name>A0A074ZAQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitinyl hydrolase variant UBP zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597069">
        <property type="protein sequence ID" value="KER20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175952.1">
        <property type="nucleotide sequence ID" value="XM_009177688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAQ8"/>
    <dbReference type="STRING" id="6198.A0A074ZAQ8"/>
    <dbReference type="GeneID" id="20325290"/>
    <dbReference type="KEGG" id="ovi:T265_11122"/>
    <dbReference type="CTD" id="20325290"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitinyl hydrolase variant UBP zinc finger" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="400" mass="44231" checksum="17C28D268FDBF314" modified="2014-10-01" version="1">MVLLAHRAFIQTNTGKSPFLLMCGRHPRLPVGQEVKLCLAARLSPEELGEQTLIDCLTSLRIKMSATVSWEHFLPAIRVPSSEDKIFKDECPFHFETAESGDGLYVCLKHFIGVGASALRKYAASADSRVFLQYKIKRTFKNRDPSSEPHPTKLALGVPGGFDLPQDRYSVTEQWALVLLPQGERVEIPCPSEGSPLADISHLVPLGMPERLAKAVSIVQHAESALLLEERARNVEAWEDENIRPISSHSLELKQLDNGVRIAPSYVNCFSTDPSSEPHPTKLALGVPGGFDLPQDRYSVTEQWALVLLPQGERVEIPCPSEGSLLADISHLVPLGMPERLAKAVSIVQHAESALLLEERARNVEAWEDENIRPISSHSLELKQLDNGVRIAPSYVGHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAT9</accession>
    <name>A0A074ZAT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175889.1">
        <property type="nucleotide sequence ID" value="XM_009177625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAT9"/>
    <dbReference type="GeneID" id="20325241"/>
    <dbReference type="KEGG" id="ovi:T265_11073"/>
    <dbReference type="CTD" id="20325241"/>
    <dbReference type="OrthoDB" id="6244027at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="272" mass="29989" checksum="ED9300198DC3864A" modified="2014-10-01" version="1">MNATVDLVTSAAVVRNATTVSEISPACIDLILNIVLSAASLLVFIGTVIITYFVDDPGLRKLKRGTQQSESVDITESDKNYIRYLAERKFQNQIKGHTFSAFSPAYNLSLTTGTEPPELRRTVPYARRRACSESHTAHRMSDASSETQIVFSKPVADVVAKSEEFHLPSLDSIDFILLFRDAIHKGSRPLVSDNFEVLSEEMVSDGVSVSVTRRLENGYLVVLQAPQSGKTSSIIEYDGSVMCYACRNTVYRDECCSPCLLQDGANREVDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB34</accession>
    <name>A0A074ZB34_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_09208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173485.1">
        <property type="nucleotide sequence ID" value="XM_009175221.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZB34"/>
    <dbReference type="GeneID" id="20323387"/>
    <dbReference type="KEGG" id="ovi:T265_09208"/>
    <dbReference type="CTD" id="20323387"/>
    <dbReference type="OrthoDB" id="10013209at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF61">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="2154"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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    <feature type="disulfide bond" evidence="10">
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        </source>
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    <sequence length="2256" mass="249604" checksum="D3A146EBDFFDBB60" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">T265_07825</name>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KER24508.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7330" checksum="8017CA2D8852697D" modified="2014-10-01" version="1">MSDTRVPIQPLRREAHVLSTHLECVRQSNQLHGTHLLLQTFLHRRQHVLSVCNDDRHNGDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
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        <lineage>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Gao S."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5001705386" description="SPARC/Testican calcium-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
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            <end position="243"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="258" mass="30187" checksum="6EFC90165039042E" modified="2014-10-01" version="1">MKLYSIFLLFGSLCIAFGQQDEWERERDVEDACANVKCRQGEWCNQGRCECLDTCASDWNNFDRKLCVDGNTYRHECDLWRNQCYCRTGDSRCGGETFNNHRANDDAVIKYFDECRDLTEMCDWEQQEDSFPIRLGIWFQELLRQKWSSGSDHPDDESLLRPMDSKARAATSKLMSPSTMDRAESGVISYWFCELDRRNKGSLDERDLSLLYQVLLPSNACLETFMNRCASSGSISFDQWHNCFDVPREERIECSRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC48</accession>
    <name>A0A074ZC48_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171373.1">
        <property type="nucleotide sequence ID" value="XM_009173109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC48"/>
    <dbReference type="GeneID" id="20321738"/>
    <dbReference type="KEGG" id="ovi:T265_07559"/>
    <dbReference type="CTD" id="20321738"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="274" mass="31372" checksum="528A91718DFDF0AC" modified="2014-10-01" version="1">MTVSYASSVATVHHGSLVRLLARWHGSVYQAVWPTFLLFCFAYGGVALIYYLLPTDTPERLEMKQQFVQVCAYAARISDAIPVSFVLGFFVNLVVSRWWKQFLNLPTPDSACYLMGTYLRGYEHKEGYYVSEQCDSERPLLIRRSVARYLNLASALCFQEISLSMKRQVGTLEDLVDCGLMTKQEETIFLNLSQDNGHFFVPVVWAVTLLSRAHHEGFIKHERHLDAIVAEVVAFWRQLHILFLHDYVNVPLVYNQVSEVFHARGIDLASLLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC80</accession>
    <name>A0A074ZC80_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171347.1">
        <property type="nucleotide sequence ID" value="XM_009173083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC80"/>
    <dbReference type="GeneID" id="20321717"/>
    <dbReference type="KEGG" id="ovi:T265_07538"/>
    <dbReference type="CTD" id="20321717"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="13102" checksum="6C0D9BCE6CDE8730" modified="2014-10-01" version="1">MSSLHGERSANEALAALRMIRRNFSRITHKDLQMFYEAYHGVKQEWRELVSLMDTALCIEPAGELAIYSNTPGSLGIQRAYYVHELPGHFLADKYVKQNRPVSRVKCALEIQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCD6</accession>
    <name>A0A074ZCD6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596858">
        <property type="protein sequence ID" value="KER23252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173000.1">
        <property type="nucleotide sequence ID" value="XM_009174736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCD6"/>
    <dbReference type="STRING" id="6198.A0A074ZCD6"/>
    <dbReference type="GeneID" id="20323003"/>
    <dbReference type="KEGG" id="ovi:T265_08824"/>
    <dbReference type="CTD" id="20323003"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF50">
        <property type="entry name" value="APOPTOSIS REGULATOR CED-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="4">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21948" checksum="2EBA9551B9DC8017" modified="2014-10-01" version="1">MSAAQTVFIEEKLEADSNIYNSVCPLDLLPTKEVLKWVIIDYVYYRICLRGYSGITLFEKDRGKTHKHVVLDLILRRLVERAEELELKLKPRFENRKAMLLSTPERAQLDFMDTLENIWADGLANWGRFLVYITFTAVYCISCLDCGMVLLIKTLVEHAINDLDAKMGRWLLAHGGWRGLLRAANDVRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCT0</accession>
    <name>A0A074ZCT0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172793.1">
        <property type="nucleotide sequence ID" value="XM_009174529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCT0"/>
    <dbReference type="GeneID" id="20322837"/>
    <dbReference type="KEGG" id="ovi:T265_08658"/>
    <dbReference type="CTD" id="20322837"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="24091" checksum="DE8ECE46ABC64B6A" modified="2014-10-01" version="1">MSIFMEAVECALMMYPRMVTKRLQANCQARRTDQQPPDKQPMNSPELPIFQQITKTLHSPTALWVRLLSRRLKVGASAILIEDYGPPLQICNARIEWLIDLRYPSSVEARDQITEVDGSERSQSAEDYNNQHIATHYYVPNKAVMMKSRLVMKRLQSNCPAQRTNQRPSTLAELPIFSSIEDCTYRTKYQLRIDNNSGEQNGKANCRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF75</accession>
    <name>A0A074ZF75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174366.1">
        <property type="nucleotide sequence ID" value="XM_009176102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF75"/>
    <dbReference type="STRING" id="6198.A0A074ZF75"/>
    <dbReference type="GeneID" id="20324058"/>
    <dbReference type="KEGG" id="ovi:T265_09890"/>
    <dbReference type="CTD" id="20324058"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="106"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="29865" checksum="4F985B8D0757509F" modified="2014-10-01" version="1">MPSVDKKKALAKKEAAGVATAGDLVNGTDEDGQTEETVPSHTEDEVPGRHRTTSVGDDGLVGSDDEDEEVHKSLVETLECLDLISNRNAQGRSVTSVLASHPGARDTRLELNIGRRYGLIDPNGCGKSTLLAVMANRELPIPNHIGIFLLQREMVPRDKTALQCVMEVDEERQRLQREAGEPAAREDTESSERLVEVYERLEHLDADKAEAKAAMLLHGLGFTKEMQQKQVKNFSGGWPMCIALARVLFVRPALVLLDVPTNHIDLNACVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFM8</accession>
    <name>A0A074ZFM8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596924">
        <property type="protein sequence ID" value="KER22040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174228.1">
        <property type="nucleotide sequence ID" value="XM_009175964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFM8"/>
    <dbReference type="GeneID" id="20323958"/>
    <dbReference type="KEGG" id="ovi:T265_09790"/>
    <dbReference type="CTD" id="20323958"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="22166" checksum="841EA0922C611781" modified="2014-10-01" version="1">MRSGCLFPTNYPANRLSFTTMRNTQKPQVIRFRTPVEFFAPYPLAFSSSTLPVPSCHATRSLHEGWDTARLTKPRQGKSRGGGQIRTTNLPVMVQSQEQSLASFSSVSSCHATWRKHKGWSIARSSRGRGRIRTKDLPVSLGNPAIFQPSCLLRVAWQLRTERVVKLNDEHCQLKVFSINFRTLQPIWNRIILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGM4</accession>
    <name>A0A074ZGM4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin-tyrosine ligase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169881.1">
        <property type="nucleotide sequence ID" value="XM_009171617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGM4"/>
    <dbReference type="STRING" id="6198.A0A074ZGM4"/>
    <dbReference type="GeneID" id="20328172"/>
    <dbReference type="KEGG" id="ovi:T265_14005"/>
    <dbReference type="CTD" id="20328172"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136145" checksum="F51FE08AE8CCFB93" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGP5</accession>
    <name>A0A074ZGP5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169870.1">
        <property type="nucleotide sequence ID" value="XM_009171606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGP5"/>
    <dbReference type="GeneID" id="20320547"/>
    <dbReference type="KEGG" id="ovi:T265_06365"/>
    <dbReference type="CTD" id="20320547"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="23902" checksum="0383A67D38A4AAE3" modified="2014-10-01" version="1">MTWQRSIKAITSKISCVGHCRLPGWGPRDGPHQWLETFRALNGADASKLLPSTHSSYSTPPLDSPLYLTPPNIGERNWGSYNHCTTSTRQHRCFHKYGHAGRLGGTPYCLHTPVAQNSTTLPPDRPVPRLLVVLIRRPARMGFERDGSSGKSANLLTGRSEGPLFELEFSRLGSGNLALSKSSCLLRVAWQLGTESALQLDDIYIFAHEYLRFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH24</accession>
    <name>A0A074ZH24_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Barrier to autointegration factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169738.1">
        <property type="nucleotide sequence ID" value="XM_009171474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH24"/>
    <dbReference type="STRING" id="6198.A0A074ZH24"/>
    <dbReference type="GeneID" id="20328142"/>
    <dbReference type="KEGG" id="ovi:T265_13975"/>
    <dbReference type="CTD" id="20328142"/>
    <dbReference type="OrthoDB" id="9997163at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30737" checksum="79F1A1864F6F0C20" modified="2014-10-01" version="1">MPLLHTPTLVVFLDFEVTFDFVDQTWQYLVTRGALSKFIYLLRTLYVIRCGHPRVYRKISPEFTTSSSVRQGYSVSPLHFNFPIGDKLVTELPGIGERLGERLEAKGFEKASVVLGQFLLLRRDEELFKDWLKEACGANAKQADDCFTALRDWCGSKQSSWTDSIKSNASRIDKSCLFFVKQALRQKVALTLRQLWKFVTVTPVREKHKYSDSGRYPEWSVLTPEEAHPDGRLRVDPHYTDNRERILIACRTSFVSSQCEHSYRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH51</accession>
    <name>A0A074ZH51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ/DHR/GLGF domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171197.1">
        <property type="nucleotide sequence ID" value="XM_009172933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH51"/>
    <dbReference type="STRING" id="6198.A0A074ZH51"/>
    <dbReference type="GeneID" id="20321594"/>
    <dbReference type="KEGG" id="ovi:T265_07415"/>
    <dbReference type="CTD" id="20321594"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16637">
        <property type="entry name" value="mRING-HC-C3HC3D_LNX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06679">
        <property type="entry name" value="PDZ3_LNX1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="464"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="568"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="804"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="921"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114574" checksum="FC04A8D7B6ADE64B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHJ1</accession>
    <name>A0A074ZHJ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596785">
        <property type="protein sequence ID" value="KER25172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171089.1">
        <property type="nucleotide sequence ID" value="XM_009172825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHJ1"/>
    <dbReference type="STRING" id="6198.A0A074ZHJ1"/>
    <dbReference type="GeneID" id="20321512"/>
    <dbReference type="KEGG" id="ovi:T265_07333"/>
    <dbReference type="CTD" id="20321512"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="102896" checksum="E600F5FEDA32FF00" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHL0</accession>
    <name>A0A074ZHL0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lsm14-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171055.1">
        <property type="nucleotide sequence ID" value="XM_009172791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHL0"/>
    <dbReference type="STRING" id="6198.A0A074ZHL0"/>
    <dbReference type="GeneID" id="20321483"/>
    <dbReference type="KEGG" id="ovi:T265_07304"/>
    <dbReference type="CTD" id="20321483"/>
    <dbReference type="OrthoDB" id="6238775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lsm14-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="357" mass="40858" checksum="8A2B58A0D3A53EF7" modified="2014-10-01" version="1">MEAIYENCVKIKSRAGIEYTGLLHSIDTEHSTVTLKRVHLSDSPTEGPVNIRSNSFDYVIFRGGDIEDVQLSFKVRRTITPAHDDAIVRVNSRPFIMNTGYNCWALNGNLKHDPAIVRIDQKANADISFPAEKSTVDSTWANGDRQSQPGMGSTEFHRKGVPQRRRSARPGRSRSNLEHSVRSLKLCASDRRCQSAEAAHQSVRTRCSGDTVNYDDMQRMKESIPSTTDQIRVYDKQHSFFDRLSSGIEGSRPASKRMSPSLDTNSKTNEHQLLPGKSSRRICYHSYPQEGMGLQPNDTYSMHHYSSVHSQTHPYIHPAYQFQYTAPYTYRQQLSLFNEPYFFNWQHVYNPVRYTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI31</accession>
    <name>A0A074ZI31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173279.1">
        <property type="nucleotide sequence ID" value="XM_009175015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI31"/>
    <dbReference type="STRING" id="6198.A0A074ZI31"/>
    <dbReference type="GeneID" id="20323225"/>
    <dbReference type="KEGG" id="ovi:T265_09046"/>
    <dbReference type="CTD" id="20323225"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="159"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30805" checksum="70277B0064BB51CA" modified="2014-10-01" version="1">MSGVLKRVTPGGTEPSARTKISVVGAGSVGMAAAFSLMEITGELCIVDVATDKVMGEVLDLQHGEQFTRRCKVHGSGDYKDTANSDIVVITAGARQVEGETRLDLVQRNVDIFKRIIPEVIKHSPNCIIVVVSNPVDVLTYVAARLSGFPPNRIMGTGTLLDSARFRHLLGEKLGVSANSVHAYIIGEHDYKQRRVFSPYDVGTPSRSDCLNAHNKQTGNYVLDNCHVVYEHADIAWLHGHVGITYAYVCGLRLNGCLNSKFTYPPGIMSIFQIEIYSDERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIB9</accession>
    <name>A0A074ZIB9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169193.1">
        <property type="nucleotide sequence ID" value="XM_009170929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIB9"/>
    <dbReference type="GeneID" id="20320004"/>
    <dbReference type="KEGG" id="ovi:T265_05822"/>
    <dbReference type="CTD" id="20320004"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="31483" checksum="288B00272B7B3604" modified="2014-10-01" version="1">MKSSIHNFEYHGLESWGYIQSCDFENMDLKGLSSDVEDQHEGFECIAHNSMLERKAIFCVVRKDANSFKKHPSSRTKPMEQNYDDIKHTPFAYFQPENFQTGEQEYFYQIDEEISGTFRSFSLVTLSMGENINTSYRLHTLFIRLLRTSRHPVTGFALLDAHQSDRSFEVIVKVGPVFQRDERILKVIIRIAALVTSRRRGPAVSVNLISFLDTDCTKLVRSTHLHKREIQRGSRSEPEEPVGHFGIITFLLRAVVSMHIHMDSCIRIGLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIX9</accession>
    <name>A0A074ZIX9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169328.1">
        <property type="nucleotide sequence ID" value="XM_009171064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIX9"/>
    <dbReference type="GeneID" id="20320111"/>
    <dbReference type="KEGG" id="ovi:T265_05929"/>
    <dbReference type="CTD" id="20320111"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8344" checksum="584CE890ADE6D6FE" modified="2014-10-01" version="1">MRSFEAAAPGEMTTAISFYFGGCLISGVEASVVYVNPRLRTNNHDQFERLLAQDLKKTFSRSVIEYKSHDSIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJE4</accession>
    <name>A0A074ZJE4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172788.1">
        <property type="nucleotide sequence ID" value="XM_009174524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJE4"/>
    <dbReference type="STRING" id="6198.A0A074ZJE4"/>
    <dbReference type="GeneID" id="20328804"/>
    <dbReference type="KEGG" id="ovi:T265_14638"/>
    <dbReference type="CTD" id="20328804"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705451" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="497" mass="57739" checksum="1F4651C3BD77AE77" modified="2014-10-01" version="1">MNSGVIFLIFPLIISCDAWNTDELQMFDLMDELKISFYDFLGVEQTASSSEIRSAYRKLSVKLHPDKNVGDPAAADKFRQLASIYEVLKDDERRKSYDEVLENGMPDWKTTVFYYRKLRKMSNIELGILFVLLSTTIHYAALWGARFERSWTLEEQLSNHYKRHKARDRRREEIDELITTELRKIPRPKWHDLLPFAICKGVYSLILALLVLLHFAKVHVSEKIEEKRQTWRELEDKKVKTEVKERKRRNKVQPTDKSTPYDAETLNAFVSLADIPPETTREPISENVEKTSNREWSEEDVIELVHAVSRFPGGVAGRWERIAAQLNRTVSDVTKKAKELGERKLYAVYQKSQMSYEIPAFETNFNAVCGETSEEEEEGADESQLDFESKTDPETPYEEVEQADVIVDEPYMSRKKQKQQKLAVRKEVTECKPSENSSDGWTQVEQKQLEVAIRSISKTTAERWDRIADCVPTKTKAEVMQRVKYLSTLAKSKATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJT4</accession>
    <name>A0A074ZJT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169003.1">
        <property type="nucleotide sequence ID" value="XM_009170739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJT4"/>
    <dbReference type="STRING" id="6198.A0A074ZJT4"/>
    <dbReference type="GeneID" id="20319856"/>
    <dbReference type="KEGG" id="ovi:T265_05674"/>
    <dbReference type="CTD" id="20319856"/>
    <dbReference type="OrthoDB" id="6283921at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="332"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118194" checksum="457209A9C959CE03" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJY7</accession>
    <name>A0A074ZJY7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168917.1">
        <property type="nucleotide sequence ID" value="XM_009170653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJY7"/>
    <dbReference type="GeneID" id="20319783"/>
    <dbReference type="KEGG" id="ovi:T265_05601"/>
    <dbReference type="CTD" id="20319783"/>
    <dbReference type="OrthoDB" id="6264054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="677" mass="73765" checksum="2EFADA3E756D0D55" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKR1</accession>
    <name>A0A074ZKR1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169857.1">
        <property type="nucleotide sequence ID" value="XM_009171593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKR1"/>
    <dbReference type="GeneID" id="20320534"/>
    <dbReference type="KEGG" id="ovi:T265_06352"/>
    <dbReference type="CTD" id="20320534"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13984" checksum="1BDBF72FECE94EDD" modified="2014-10-01" version="1">MDPRVKYRNVKAVDCEEVQKMTEYFKSKSKAIEEKIIALSEAREQKKAVDRARVITNIWKEECIQLRAEEREINGQIRCQTYGWILSDPETANLIRILEEEEREFQQNLVKPLWTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLG0</accession>
    <name>A0A074ZLG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169658.1">
        <property type="nucleotide sequence ID" value="XM_009171394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLG0"/>
    <dbReference type="STRING" id="6198.A0A074ZLG0"/>
    <dbReference type="GeneID" id="20320375"/>
    <dbReference type="KEGG" id="ovi:T265_06193"/>
    <dbReference type="CTD" id="20320375"/>
    <dbReference type="OrthoDB" id="1695393at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12545" checksum="7F5295F07FC18C65" modified="2014-10-01" version="1">MEESLFLWLVPGLDRVRLDLIEAGDIVRTHEVEQCLSDLYSRIRSDEAGAGSRKQKESGGLRSAVTAHLAKLAIRGTNHKTTSPVQRTTLSAGPEGKTLGRNKPSRLSLKKRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM86</accession>
    <name>A0A074ZM86_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase family A16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171755.1">
        <property type="nucleotide sequence ID" value="XM_009173491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM86"/>
    <dbReference type="STRING" id="6198.A0A074ZM86"/>
    <dbReference type="GeneID" id="20322030"/>
    <dbReference type="KEGG" id="ovi:T265_07851"/>
    <dbReference type="CTD" id="20322030"/>
    <dbReference type="OrthoDB" id="6283332at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41870" checksum="8F8B33A398566BAF" modified="2014-10-01" version="1">MSQSDDGLRPPVLSRNASPTERDAVHSSDNRHMELELARLRIRELEIQLELQKLSEAKAKRNNQDECDSHTQLQSDPADSKSIAFALERRLELPKRELQRFNGNPKDYWAFMKAFSSTIEDRTRDDEARLGYLIQYCDGEAKRRIEHCTVLRPNEGYGLAKEILRKRFGQNYMVARAFIDDLITGPTIKDGDSSTLSDLAQQLTVCEVTLREMDYSSDLNSQHTIQTIVRRLPSRLRFKWAKAVANIRREDREPEVTDLTAFIEARVDSLCSDYGEPALSLASEERARKRPPLSGQIHGRNIHSTQTLASRTGIDPRCGVCGEAHYPDQCAQFIAESSEKRREIVMRRKLCNLCLRPNHVAKICRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMC1</accession>
    <name>A0A074ZMC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171741.1">
        <property type="nucleotide sequence ID" value="XM_009173477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMC1"/>
    <dbReference type="STRING" id="6198.A0A074ZMC1"/>
    <dbReference type="GeneID" id="20328569"/>
    <dbReference type="KEGG" id="ovi:T265_14403"/>
    <dbReference type="CTD" id="20328569"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="226" mass="25950" checksum="B654D85B58E1AC77" modified="2014-10-01" version="1" fragment="single">SYPTPQKAQKDKEPKQQAAENEVTSVQKDEVTTDKTTKTTNSKETQAATKLEPKAETPKSHQSTDSQARRSAKPGNKQSRRSGSTARGKRSSRTLNAKETEKTAIEQENADASSVKQEQVLPPKPGEEGWCYVDRLIPLDSASVLIHFYEDMENSYKRNCMSIFRVLRRDRWAVLPHLHKARTEFYNYLRRPDMKQHYVTQFQEVSCGLLYLTISVRVMLLNMRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMD7</accession>
    <name>A0A074ZMD7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168025.1">
        <property type="nucleotide sequence ID" value="XM_009169761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMD7"/>
    <dbReference type="STRING" id="6198.A0A074ZMD7"/>
    <dbReference type="GeneID" id="20319083"/>
    <dbReference type="KEGG" id="ovi:T265_04901"/>
    <dbReference type="CTD" id="20319083"/>
    <dbReference type="OrthoDB" id="348005at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052004">
        <property type="entry name" value="Dynein_assembly_factor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 4, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="42859" checksum="00BAF950106B8C74" modified="2014-10-01" version="1">MITSRFIKMVIKPYMFECILLNPILVDESRVELSGSQARFVLKKAEAQIWGRLLSEEMKDKHKLIQLRNEAIIEHQEREKAKQEAKLQEIRKGEKDSLNKVMKLEADERERIESEKKFAGEKAVEELVKIHQQEQEEKAQLDQKIIEARQLANEITEQRIMITKSPEERIALSLNEKPIELPVRTSTNITVNFTPRIFPTPERESVKQEEEEWLNKQAEHRRAMLKKVVGDQEMSDKELDPQWLRNKGDTLFRAGDFEAAVEAYSRAIEINPKMHSAFSNRAACHLQLRNFFKALEDSSTALDLCVPAVPQNLRSRVRAHARRAAAFCNLKMFKEGLIEYRAAHQLDPSDSSIEADMRNIEKYLNQLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMN7</accession>
    <name>A0A074ZMN7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167858.1">
        <property type="nucleotide sequence ID" value="XM_009169594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMN7"/>
    <dbReference type="GeneID" id="20318951"/>
    <dbReference type="KEGG" id="ovi:T265_04769"/>
    <dbReference type="CTD" id="20318951"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14472" checksum="CC8D504941B94552" modified="2014-10-01" version="1">MALVRSTRLPGFEPFNAMNLLRAERHAKWTRTGDRKEVVRDCRSFNIEAKARKKITKQEPLSRHVARCLRWLERGFTNRKVRGLNPTYAPQLFLSGLGQPGGIPALVLPSGSMAARHRKGVTDEQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMT6</accession>
    <name>A0A074ZMT6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169135.1">
        <property type="nucleotide sequence ID" value="XM_009170871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMT6"/>
    <dbReference type="STRING" id="6198.A0A074ZMT6"/>
    <dbReference type="GeneID" id="20319959"/>
    <dbReference type="KEGG" id="ovi:T265_05777"/>
    <dbReference type="CTD" id="20319959"/>
    <dbReference type="OrthoDB" id="6288581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="533" mass="58092" checksum="F49651E0B4B7DBB6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNS7</accession>
    <name>A0A074ZNS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171288.1">
        <property type="nucleotide sequence ID" value="XM_009173024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNS7"/>
    <dbReference type="GeneID" id="20321670"/>
    <dbReference type="KEGG" id="ovi:T265_07491"/>
    <dbReference type="CTD" id="20321670"/>
    <dbReference type="OrthoDB" id="6235294at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cystatin" evidence="1">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19326" checksum="F9DC951B423238C5" modified="2014-10-01" version="1">MMPGGKQPLTEVDLESELFQGFVGQAEIKCNQAVNSVSWFVREGPINGTKQVVSGIKYEFNFLQQESDCKKEAKLAGDNETSCEIKENGLEHLCSAHVLYAPHAGPTVVEVEVADVSEGDANQEGEKKVLESVEAVLAMLDAFFESSTVYFTRDPFPDRLIENSLTPADSRCFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNV0</accession>
    <name>A0A074ZNV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flotillin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167208.1">
        <property type="nucleotide sequence ID" value="XM_009168944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNV0"/>
    <dbReference type="STRING" id="6198.A0A074ZNV0"/>
    <dbReference type="GeneID" id="20318437"/>
    <dbReference type="KEGG" id="ovi:T265_04251"/>
    <dbReference type="CTD" id="20318437"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704183" description="Flotillin C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Flotillin C-terminal" evidence="4">
        <location>
            <begin position="252"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="367" mass="40634" checksum="FC21648B5A2BF990" modified="2014-10-01" version="1">MWPAKTRSRDWWTKVYLALFAKGGAAEFEVASSDLVNMGISVVSYTLKDIKDDEGYLESLGLARTAQVKRDARIGEAEARRDAGIREAEAEQKRVAGRLLNDVEIAKAKRDFELQNAGYEKEVQARKAESEMAYELQAAKTRQKIKEEEMQIAVLERTQQIQVEELENVRQERHLDATVRKPAEAERFRLERLAEAERMRLTAEAEAEAESIRLKGLAEAEALEAVAKAEAEQMMKKAEAWQAYKRSLLTAEAEAEAESIRLKGLAEAEALEAVAKAEAEQMMKKAEAWQAYKGAAKLDMVLEALPKIAAEVSAPLSECGRVTMVSTGDGEIGISKLTGEVLTLMARLPQVVQSMTGIDVGKAMQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQZ2</accession>
    <name>A0A074ZQZ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170503.1">
        <property type="nucleotide sequence ID" value="XM_009172239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQZ2"/>
    <dbReference type="STRING" id="6198.A0A074ZQZ2"/>
    <dbReference type="GeneID" id="20321036"/>
    <dbReference type="KEGG" id="ovi:T265_06857"/>
    <dbReference type="CTD" id="20321036"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="25295" checksum="020E32A645BB79AE" modified="2014-10-01" version="1">MTQFLGTWKLKDSRNFDAILQKLGVNVVKRKLITSSKPEVTYTIDGNKMTIRTCSALKTTTITFEFGKEFEERTADDRTVMSTFTKQSESKITQVQKHPNSVTTTVREVSGNTLTAVIVSEDVLISINFNQKVFICLMSFTCMMHRLKHETAPCSTLICLETSQTRDSAGFQCFIVATSINVSLGEMAQWVEREFSDQTFASGLPLSRLGQPDSIPALPSGGMIVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSC9</accession>
    <name>A0A074ZSC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165862.1">
        <property type="nucleotide sequence ID" value="XM_009167598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSC9"/>
    <dbReference type="GeneID" id="20317366"/>
    <dbReference type="KEGG" id="ovi:T265_03179"/>
    <dbReference type="CTD" id="20317366"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8144" checksum="DC20E3C60EA89C15" modified="2014-10-01" version="1" fragment="single">GKSCETYGRTSNSVERYPYDIQYLTLLQFVRTCNLPLHQGDQSDDHCLPTVHYRGREADLGFAKVSYRCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT40</accession>
    <name>A0A074ZT40_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER29002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167257.1">
        <property type="nucleotide sequence ID" value="XM_009168993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT40"/>
    <dbReference type="STRING" id="6198.A0A074ZT40"/>
    <dbReference type="GeneID" id="20318476"/>
    <dbReference type="KEGG" id="ovi:T265_04294"/>
    <dbReference type="CTD" id="20318476"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="18582" checksum="94BF96E697F8CA30" modified="2014-10-01" version="1">MNIYFGSMATPPYAVHASTPRGPKPSLNQNSSNNVPLLKPQAALVALLSGQHSNDVEEQSRSPLDVILRRGSEANPWGFRIQGGSDYHLQLTVCKTQSGSPSEGVLYRGDAIIAINGETTRNLSHGEATEKIRSSGTELQMTISRKLREDFSDLRPKGPFKFSAPQYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTA4</accession>
    <name>A0A074ZTA4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165873.1">
        <property type="nucleotide sequence ID" value="XM_009167609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTA4"/>
    <dbReference type="GeneID" id="20317377"/>
    <dbReference type="KEGG" id="ovi:T265_03190"/>
    <dbReference type="CTD" id="20317377"/>
    <dbReference type="OrthoDB" id="6225467at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12337" checksum="847D628E72049ED7" modified="2014-10-01" version="1">MRRPCAAHSVACKHHEREIQLGSDESLEKPRKLLTRLPKTQRRPTTGFALLGAHQIGLFSRNTLICKSICFLRDSTESLVYDVLQLNVLHTGRLMFQLARYWHDIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWX5</accession>
    <name>A0A074ZWX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168412.1">
        <property type="nucleotide sequence ID" value="XM_009170148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWX5"/>
    <dbReference type="GeneID" id="20319386"/>
    <dbReference type="KEGG" id="ovi:T265_05204"/>
    <dbReference type="CTD" id="20319386"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="22346" checksum="05B75184FCFE0A1D" modified="2014-10-01" version="1">MRGSRRICFLQSAKAVIGLGLPKVTVSDLRLLVIVGSLRTYDTFMRVFITRSVWGCEQNRSDVTSFRCLTAIPPEGNTRAGILPGYPSLYRRSRETEVGFEPRNFRSVNSRSNHLGHLAQVHVIEIMALAIFITRSVWGCKQNRSDVTSFRCLTAIPPEGNPRAGILPGYPSLYRRSRDTEVRFEARTFRSVNSRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX75</accession>
    <name>A0A074ZX75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164638.1">
        <property type="nucleotide sequence ID" value="XM_009166374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX75"/>
    <dbReference type="STRING" id="6198.A0A074ZX75"/>
    <dbReference type="GeneID" id="20327108"/>
    <dbReference type="KEGG" id="ovi:T265_12940"/>
    <dbReference type="CTD" id="20327108"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="16662" checksum="D68BFB0889689B4F" modified="2014-10-01" version="1" fragment="single">KPSYSAKLSVGRVAVDSANDYSQSTNANNDLGLITVDLESSLDHLFNWNVKQLFVYLTAEYQTPENRVNEVVLWDKIIQRGSKANLMYRNMNSKYYFWDDGHGLRGNPNVTLKLYVNTIPNVGLLSFLTTTGSFTFSFPSTYTSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXI3</accession>
    <name>A0A074ZXI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164440.1">
        <property type="nucleotide sequence ID" value="XM_009166176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXI3"/>
    <dbReference type="STRING" id="6198.A0A074ZXI3"/>
    <dbReference type="GeneID" id="20316216"/>
    <dbReference type="KEGG" id="ovi:T265_02028"/>
    <dbReference type="CTD" id="20316216"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="200" mass="21937" checksum="33C1D57855E79367" modified="2014-10-01" version="1">MDQENAAFDNESLKLLNEPIRDTVMRSLKGVGTKFSHVLFPRKGQELLKEWDLWGPLTLCLIMSVLLHSGSAADSAGDGGPEFAQIFVIFWLGATVVTVNSKLLGGSISFLQTVCILGYCILPLVISLVVCRVLLLAASDSLWIFVIRLSIVAFGLIYSSFASFVFLTPTQPPNRVGLALYPICLFYFFLAWLVISVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ71</accession>
    <name>A0A074ZZ71_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynein axonemal heavy chain 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Axonemal beta dynein heavy chain 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ciliary dynein heavy chain 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_02480</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164993.1">
        <property type="nucleotide sequence ID" value="XM_009166729.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZ71"/>
    <dbReference type="GeneID" id="20316668"/>
    <dbReference type="KEGG" id="ovi:T265_02480"/>
    <dbReference type="CTD" id="20316668"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="1224"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="1900"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1852"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2703"/>
            <end position="2768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KER31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3959" mass="451778" checksum="7224A4206BAE2069" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ90</accession>
    <name>A0A074ZZ90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164877.1">
        <property type="nucleotide sequence ID" value="XM_009166613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ90"/>
    <dbReference type="GeneID" id="20316568"/>
    <dbReference type="KEGG" id="ovi:T265_02380"/>
    <dbReference type="CTD" id="20316568"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6621" checksum="77A1098B954295B9" modified="2014-10-01" version="1">MEKARKRKRNFLKHASSSPEWPASDRPPSLKVDIMLIPGRPALKTRSTAGRSISHNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZV8</accession>
    <name>A0A074ZZV8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BRCA1-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164648.1">
        <property type="nucleotide sequence ID" value="XM_009166384.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZV8"/>
    <dbReference type="GeneID" id="20316384"/>
    <dbReference type="KEGG" id="ovi:T265_02196"/>
    <dbReference type="CTD" id="20316384"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12718">
        <property type="entry name" value="RRM_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034932">
        <property type="entry name" value="BRAP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="380"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57062" checksum="95DB568FF5CEE118" modified="2014-10-01" version="1">MQXNAAPNFPYPFAAKNSLGCLPCSDFADLGASRVGKRSFTQLAIESYSLRDLAASSMNELQPEIEAIEFRSGNPVVETTEGFIHVYKNAKEVGVTDSRVSSTMLCIFSVPSYLTVKDLLSFVAPMRDSVEELKVVKNGGPNHYMALLKFRSEQETDQFYHTYNNTCYRNLESEVCQLMYVSHVDKTHPAMGTAFPTKDLLELPSCPVCLERLDEPVQGILTTILCNHSFHDECIARVEDITCPVCRYMQSPELLDESQCADCCIRDNLWICLICGRIGCGRYGRKHAQLHFEQTGHTFALELGKNLVWDYADDAYVHRLAVNHEDGKLVQVGAGSETGDKKLDLMSMEFSAVLTSQLESQRAYFESQLERITTESAIRIQAAESKVEELSSTLNQVQQQLNELTKEKSSTIRKLQQKELEEERALNKSLLNNESIWRSRAEKAEAEAKTSKEECKELLLNLEFRSKLTEFASSEQLSSGELENCEISIQQHPNQPSSCRRRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A038</accession>
    <name>A0A075A038_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_02137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164575.1">
        <property type="nucleotide sequence ID" value="XM_009166311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A038"/>
    <dbReference type="STRING" id="6198.A0A075A038"/>
    <dbReference type="GeneID" id="20316325"/>
    <dbReference type="KEGG" id="ovi:T265_02137"/>
    <dbReference type="CTD" id="20316325"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="485"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112974" checksum="800EEEA5FBEB8E74" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0A6</accession>
    <name>A0A075A0A6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167280.1">
        <property type="nucleotide sequence ID" value="XM_009169016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0A6"/>
    <dbReference type="GeneID" id="20327634"/>
    <dbReference type="KEGG" id="ovi:T265_13467"/>
    <dbReference type="CTD" id="20327634"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15575" checksum="D5E8306DD1CB7DB0" modified="2014-10-01" version="1">MKGLREDYPKNITYRGKPRRGLEHCIVTYLLFLQNSVNCIQQIRSFANLVFAGDSTESLVYDILHLNMLHKDRFMFQLVRLLKVLSQPTTDFVLLGLYQAQSSRFRQSYVLPEAQLDRSQQVIPSVYELDCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0U4</accession>
    <name>A0A075A0U4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162960.1">
        <property type="nucleotide sequence ID" value="XM_009164696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0U4"/>
    <dbReference type="STRING" id="6198.A0A075A0U4"/>
    <dbReference type="GeneID" id="20315012"/>
    <dbReference type="KEGG" id="ovi:T265_00824"/>
    <dbReference type="CTD" id="20315012"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000007">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="667"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="761"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="763"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="836" mass="93092" checksum="1A403A0C2524A21A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1A1</accession>
    <name>A0A075A1A1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_01811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164185.1">
        <property type="nucleotide sequence ID" value="XM_009165921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1A1"/>
    <dbReference type="STRING" id="6198.A0A075A1A1"/>
    <dbReference type="GeneID" id="20315999"/>
    <dbReference type="KEGG" id="ovi:T265_01811"/>
    <dbReference type="CTD" id="20315999"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="682" mass="76015" checksum="2B5DAD37D5414415" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1H6</accession>
    <name>A0A075A1H6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162550.1">
        <property type="nucleotide sequence ID" value="XM_009164286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1H6"/>
    <dbReference type="GeneID" id="20314670"/>
    <dbReference type="KEGG" id="ovi:T265_00482"/>
    <dbReference type="CTD" id="20314670"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9704" checksum="0256857E681DA555" modified="2014-10-01" version="1">MLLSSFGQPDSISALLVSSGGVPAMRPKGVTPEPSPTEFEKHTHLQINLVFTEDSIGSLVYVLQLNVPHTGRLMIQLARYSRYRSTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1J2</accession>
    <name>A0A075A1J2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Folliculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_00896</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the folliculin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163055.1">
        <property type="nucleotide sequence ID" value="XM_009164791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1J2"/>
    <dbReference type="STRING" id="6198.A0A075A1J2"/>
    <dbReference type="GeneID" id="20315084"/>
    <dbReference type="KEGG" id="ovi:T265_00896"/>
    <dbReference type="CTD" id="20315084"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1730">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044886">
        <property type="entry name" value="FLCN_DENN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032035">
        <property type="entry name" value="Folliculin_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16692">
        <property type="entry name" value="Folliculin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="17">
        <location>
            <begin position="113"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="723" mass="77032" checksum="F522BFEE9A19D2AD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1S8</accession>
    <name>A0A075A1S8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162954.1">
        <property type="nucleotide sequence ID" value="XM_009164690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1S8"/>
    <dbReference type="STRING" id="6198.A0A075A1S8"/>
    <dbReference type="GeneID" id="20315006"/>
    <dbReference type="KEGG" id="ovi:T265_00818"/>
    <dbReference type="CTD" id="20315006"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="52" mass="5838" checksum="701FC9022BCE57A0" modified="2014-10-01" version="1">MGDSTATTNKDPSSEHINLKVQGQEGSIVHFKIKKTTPLRKLMNAYCERMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A214</accession>
    <name>A0A075A214_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162464.1">
        <property type="nucleotide sequence ID" value="XM_009164200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A214"/>
    <dbReference type="GeneID" id="20314615"/>
    <dbReference type="KEGG" id="ovi:T265_00427"/>
    <dbReference type="CTD" id="20314615"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7602" checksum="605BDAEFEEE14801" modified="2014-10-01" version="1">MYQNELQKDDLKFWSLRRKASEPRHNRTTFTGLTLAECRYVEGGKIFSLSPVHLSRPTGPQKDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A237</accession>
    <name>A0A075A237_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162531.1">
        <property type="nucleotide sequence ID" value="XM_009164267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A237"/>
    <dbReference type="STRING" id="6198.A0A075A237"/>
    <dbReference type="GeneID" id="20326711"/>
    <dbReference type="KEGG" id="ovi:T265_12543"/>
    <dbReference type="CTD" id="20326711"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22586" checksum="BBA711EBADFE5A1D" modified="2014-10-01" version="1" fragment="single">MAHRDFATEHYATLLRDLNSVNIPRRSAVRGSPSNVEQHFPSNSRESIGELQPEIKLLEYTSLPEYKSSDHRPVVGSFEFAVPSRWFSLPVSFIEPMGKASKTFNCQAAMPPEGSTRAEILPGCPCLGNSSRGASIGWPKWLEREFTDRKIRGSNPTYVSRLPLSRLGQPGSIPALVLPSDGMAARHRRGATAELNASANSLLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U5</accession>
    <name>A0A075A2U5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174552.1">
        <property type="nucleotide sequence ID" value="XM_009176288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2U5"/>
    <dbReference type="STRING" id="6198.A0A075A2U5"/>
    <dbReference type="GeneID" id="20324205"/>
    <dbReference type="KEGG" id="ovi:T265_10037"/>
    <dbReference type="CTD" id="20324205"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="33456" checksum="55F91F71077E54F2" modified="2014-10-01" version="1">MRILPLAGILPRAENIKSSATHFFHWCLSGERQALTDKDKTNLGNLGKRLDPVYQSMNPCIELNGQLFYRRRSQVARGFHYSRAPAMGFQKKAIIIDGKDHLLGRLAAIVAKTLLNGQNVVVVRCEQINISGSFYRNKLKYLDFLRKRMSTNPSRGPYHFRAPAKIFWRTVRGMLPHKLYRGKEALDRLKVFEGIPPPYDKKKRMVVPSALRVMRLKQRRKFCVLSRLSHEVGWKYKNVIEKMENRRKAKSAVWYKKKRLAVKPVEAARSRAREAIAPYEAILKQYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A356</accession>
    <name>A0A075A356_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162496.1">
        <property type="nucleotide sequence ID" value="XM_009164232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A356"/>
    <dbReference type="GeneID" id="20314647"/>
    <dbReference type="KEGG" id="ovi:T265_00459"/>
    <dbReference type="CTD" id="20314647"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="390" mass="43672" checksum="56665B1FE19BD254" modified="2014-10-01" version="1">MQPDYSGPSLMMASSQIQNGLLNTGVLGRPSFFARPSSAALEQDGAKTSNCELPHRDSLTAEREDHTEKMRDSKYKPFSSVPPSVPIGGANQIQVSNQKIGMHSANGESQTVCASRGVDYLIESIKTYRCECCSKFCQLFAHPIERKRALLIICLFFLFLISTIIFVVALMLRRTESKSIFEDSAAEIIKPTDFPHQKISSVNETVQSVCMNVSCLRMASILTEHLGQFKNPVLFEELRGECDPTSLGKLTRLLAFGENQRSTSNTNSIVTLKQRLTNAVWTSISETLQSIPTEPWESKWFQKLAFIYQRLISASPNFGFRDTSTVGHSGDGTVPDKSHIEFSEQRDEYFLQNMRAHSDEERLRQLLQRGNIAFHGLGKSKDVALFSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4B8</accession>
    <name>A0A075A4B8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165844.1">
        <property type="nucleotide sequence ID" value="XM_009167580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4B8"/>
    <dbReference type="GeneID" id="20317354"/>
    <dbReference type="KEGG" id="ovi:T265_03167"/>
    <dbReference type="CTD" id="20317354"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15132" checksum="501CF91B7ACC6261" modified="2014-10-01" version="1">MCCTRPPHVSVATILEISRHMHRLCLETPQTKDSDSDSDEFPAKPNLFANEYWVALDEESCVANGEHYAECSYAKSPSTKLLTGKSVVRTRPLPLDFSCLRLGNLAVSQSSYFLWVARQPGTKMVLQLNGHFMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4I1</accession>
    <name>A0A075A4I1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163013.1">
        <property type="nucleotide sequence ID" value="XM_009164749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4I1"/>
    <dbReference type="STRING" id="6198.A0A075A4I1"/>
    <dbReference type="GeneID" id="20315042"/>
    <dbReference type="KEGG" id="ovi:T265_00854"/>
    <dbReference type="CTD" id="20315042"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="975" mass="108502" checksum="1669360045888376" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4V4</accession>
    <name>A0A075A4V4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165603.1">
        <property type="nucleotide sequence ID" value="XM_009167339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4V4"/>
    <dbReference type="GeneID" id="20317148"/>
    <dbReference type="KEGG" id="ovi:T265_02960"/>
    <dbReference type="CTD" id="20317148"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10306" checksum="E3A27518F6D4F95B" modified="2014-10-01" version="1">MCQCAFDRHTSCRNIRRARVTAELKTEFFTPSDFDSKTLTSQRDTLSRDIAVFRGIGNKLGGPEGKPVDYPSKYMDLIQRSRSIPEEYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A513</accession>
    <name>A0A075A513_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162822.1">
        <property type="nucleotide sequence ID" value="XM_009164558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A513"/>
    <dbReference type="GeneID" id="20314897"/>
    <dbReference type="KEGG" id="ovi:T265_00709"/>
    <dbReference type="CTD" id="20314897"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="20608" checksum="CC115F25FFAFD851" modified="2014-10-01" version="1">MTSSRSAEDKITIATSKINKALGTYFEKTVNNTCSKIKQKDEEWFQQTVTELVQEFQQRCEEGLPSLLKKYSVNDKASQLEYANQNLRFSRSWCPSGDPEKDIRAHLYVVEKEHLDDLCKRTSDLQREIRPRLAELKREDYRLRDESTKLQVLLKQLCTTLATVQSAENHLCVHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A673</accession>
    <name>A0A075A673_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ/DHR/GLGF domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596872">
        <property type="protein sequence ID" value="KER22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173317.1">
        <property type="nucleotide sequence ID" value="XM_009175053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A673"/>
    <dbReference type="STRING" id="6198.A0A075A673"/>
    <dbReference type="GeneID" id="20323253"/>
    <dbReference type="KEGG" id="ovi:T265_09074"/>
    <dbReference type="CTD" id="20323253"/>
    <dbReference type="OrthoDB" id="439127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="234"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="59028" checksum="44B1EFAEE5B4BFEB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6B3</accession>
    <name>A0A075A6B3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent helicase ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_00335</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162344.1">
        <property type="nucleotide sequence ID" value="XM_009164080.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A6B3"/>
    <dbReference type="GeneID" id="20314523"/>
    <dbReference type="KEGG" id="ovi:T265_00335"/>
    <dbReference type="CTD" id="20314523"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="120"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="1327"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1756"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="965"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1647"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1125"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1658"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2194" mass="246816" checksum="01659675ABA06BF4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6L4</accession>
    <name>A0A075A6L4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162176.1">
        <property type="nucleotide sequence ID" value="XM_009163912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6L4"/>
    <dbReference type="GeneID" id="20314392"/>
    <dbReference type="KEGG" id="ovi:T265_00204"/>
    <dbReference type="CTD" id="20314392"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="21841" checksum="6D4777BEDE42E8C0" modified="2014-10-01" version="1">MLSSGKPDTVDAVSRFCATNGSRIEWDVAYKINSKKKRLVTFSKARRILFIRLLVHLRLELNMKKKCNSHPTERCERRKESERNSHTLETVLERKPLNYQLPRPQNGNDRHLAKRKQLLSNPTVDAHIEGSTGLRNGPHVFPLATTADSDLSSTGLLHCCTKLLTQTHDTGSKEFAKGKVVTNNRTLSLGQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A705</accession>
    <name>A0A075A705_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_02353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164831.1">
        <property type="nucleotide sequence ID" value="XM_009166567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A705"/>
    <dbReference type="STRING" id="6198.A0A075A705"/>
    <dbReference type="GeneID" id="20316541"/>
    <dbReference type="KEGG" id="ovi:T265_02353"/>
    <dbReference type="CTD" id="20316541"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="40985" checksum="1482CF6A96E82735" modified="2014-10-01" version="1">MEKAFATGNSRALYQLIRSTGPRKATVSETINGKDGSSIHSQRRRLDRWAEHLEEHFRWPHTTQPVELECKYHPYAVLIEDSHAGDMVCSMCGLVVADRVIDVGSEWRTFSNDANAKDMCRVGSSENPLLSGSDLSTMISGPSFSDSRQVDDQGKALYKSRRHLSSADRVLTGAFREIGQMAEHLNLPKSISDHANLLFKQVYETKNLRGRSNDAVSTACLYMACRQEGVPRTFKEVCAVSRVSKKEIGKVFKKILKILETNVQSVTVEDFMSRFCGNLNLNIAVQRVANVVARRALNLNLVAGRSPVSVAAAAIYMAACALGYQKEKREIGEVAGCAEATITCAYRAMHARASELFPEDVRLSIRPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7E7</accession>
    <name>A0A075A7E7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172849.1">
        <property type="nucleotide sequence ID" value="XM_009174585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7E7"/>
    <dbReference type="GeneID" id="20322884"/>
    <dbReference type="KEGG" id="ovi:T265_08705"/>
    <dbReference type="CTD" id="20322884"/>
    <dbReference type="OrthoDB" id="10459777at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12683" checksum="69A8064B4A64BC80" modified="2014-10-01" version="1">MPPKGCTRAGILPGCPGLCRGSREAKVGFEPRTFGSHVLHCRTGTRGGQLPERPHLDRRTIRVFNQSLWLISLTARQWCLAGNTDYQITISTEQVATCSNPQPAGPGDCVRQTSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7F1</accession>
    <name>A0A075A7F1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172853.1">
        <property type="nucleotide sequence ID" value="XM_009174589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7F1"/>
    <dbReference type="GeneID" id="20322888"/>
    <dbReference type="KEGG" id="ovi:T265_08709"/>
    <dbReference type="CTD" id="20322888"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12148" checksum="B409896C3FF1AD91" modified="2014-10-01" version="1">MDGGVVGSADLLSVDRDPMSQLMKASGNSFPDRPASEIHPDINSNSFGGTATKRRCHAVGVDDGDDDDDDDDDDDDNDDRVNASCTASYPEVSSDIYPVWNILPIYASRIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7H7</accession>
    <name>A0A075A7H7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172843.1">
        <property type="nucleotide sequence ID" value="XM_009174579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7H7"/>
    <dbReference type="STRING" id="6198.A0A075A7H7"/>
    <dbReference type="GeneID" id="20328810"/>
    <dbReference type="KEGG" id="ovi:T265_14644"/>
    <dbReference type="CTD" id="20328810"/>
    <dbReference type="OrthoDB" id="10262375at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052628">
        <property type="entry name" value="CFAP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="90026" checksum="2FB95BAA83386EBD" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A836</accession>
    <name>A0A075A836_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596842">
        <property type="protein sequence ID" value="KER23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172633.1">
        <property type="nucleotide sequence ID" value="XM_009174369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A836"/>
    <dbReference type="STRING" id="6198.A0A075A836"/>
    <dbReference type="GeneID" id="20328767"/>
    <dbReference type="KEGG" id="ovi:T265_14601"/>
    <dbReference type="CTD" id="20328767"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="4">
        <location>
            <begin position="109"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="34303" checksum="609DA7324B2D97FF" modified="2014-10-01" version="1" fragment="single">MGSKESPVDRRPRFGGRHLEVDSDVYSYNAWDDVAWSVEMEEEARKLIAINGAQKLSVEQRGKYEANACEYWDQFYLRHDEKFFKDRSWLATEFPDLFTQTTERRTIFEVGCGAGNTTIPILRGTRQSNIFIYASDFSLKAVNLLKQSDEYDPARCHAFVYDATRVDVKLPFAPGSLDYILLIFVFSALNPECLPSVLQNLVSYLKPGGKILFRDYGRYDMAQLRFKNGKCLADNFYVRSDGTLVYFFDQDELRGLFTGAGVEEVQNKVDRRLLVNRKRRLKMYRVWIQCVYKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9W1</accession>
    <name>A0A075A9W1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163710.1">
        <property type="nucleotide sequence ID" value="XM_009165446.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A9W1"/>
    <dbReference type="GeneID" id="20315608"/>
    <dbReference type="KEGG" id="ovi:T265_01420"/>
    <dbReference type="CTD" id="20315608"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="258" mass="29450" checksum="C5551584FFED5374" modified="2014-10-01" version="1">MGNPYGARLMGTQDIAVDRCQWHXLLSFLFRLFECVFGVVFDGWTKGNILRRENVDFYAVLEVEKEATPADIKRAYRRVTKFSHKQLALRFHPDKNPDDPNASEKVRRFYFFLPLCQFKEINRAHAVLSDPTKRRIYDQYGSFGIYLAEQVDEDTMRAYFALQNPCLKCCLGTLFILSCCCCCLCCCCCCNFCCGHCRPAHEQDDFRDILEEEAARNASNSPQELNEQSPVTDQPGSFPATPVGFNAASTLVNDVQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABE7</accession>
    <name>A0A075ABE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal L37ae protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171293.1">
        <property type="nucleotide sequence ID" value="XM_009173029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABE7"/>
    <dbReference type="STRING" id="6198.A0A075ABE7"/>
    <dbReference type="GeneID" id="20328468"/>
    <dbReference type="KEGG" id="ovi:T265_14302"/>
    <dbReference type="CTD" id="20328468"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9959" checksum="36F086A52F9A70A0" modified="2014-10-01" version="1" fragment="single">AKRTKKVGIVGKYGVRYGASLRKTIKKLEVSQHAKYNCNFCGKDSLKRKAVGIWECKACKKVLAGGAYVCSTTAAATTRAAIRRLRDAHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC10</accession>
    <name>A0A075AC10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171062.1">
        <property type="nucleotide sequence ID" value="XM_009172798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC10"/>
    <dbReference type="STRING" id="6198.A0A075AC10"/>
    <dbReference type="GeneID" id="20321490"/>
    <dbReference type="KEGG" id="ovi:T265_07311"/>
    <dbReference type="CTD" id="20321490"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="257" mass="28393" checksum="D44FEAB157A5A0FE" modified="2014-10-01" version="1">MRILALASILLRAKNIKSSATPFFHLCLSGERQPMTDKHRIDPENLGKSLDPVYQSWQIWPNSLHSIMAACVAVISDSNQLLYLRTAECPDPLFYHFKVHAALDVVGDKLAKRATYSGGGHEHTEPYLGLLYPMEDHRLYGYVTNTQIKFIVVLESPTSPPNSTSQSAGGSSPSLQHQDSEIRNLFQCLHSAYVDLVSSPFYTPKTPILPEKLSAAARFDRRVSELLAERASSGVCPLLSFTVQETPTTTAAVPIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACQ5</accession>
    <name>A0A075ACQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162458.1">
        <property type="nucleotide sequence ID" value="XM_009164194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACQ5"/>
    <dbReference type="GeneID" id="20314609"/>
    <dbReference type="KEGG" id="ovi:T265_00421"/>
    <dbReference type="CTD" id="20314609"/>
    <dbReference type="OrthoDB" id="6236709at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="264" mass="29214" checksum="CD6938E045EC7BF1" modified="2014-10-01" version="1">MGQNASKRVALTYIKNTAEMTARLLRQHNTMFAYKPTNTLRRTLSRPKGKLDPTAKKNVIYRIECKDCDKRSKVGLLVTTAFNLITCMGVDENAALVSTSDDLLTDICYTSECRIERGRKRQRSSKSAATATSSANFDKVIDLGAKSLYSAFNLITCMGVDENAALVSTSDDLLTDICYTSECRIERGRKRQRSSKSAATATSSANFDKVIDLGAKSLYSDPSIIQYTKDCLAASSLPRRFLVDQSSEVYRLIKFTGSPFKPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADE1</accession>
    <name>A0A075ADE1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170229.1">
        <property type="nucleotide sequence ID" value="XM_009171965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADE1"/>
    <dbReference type="GeneID" id="20320824"/>
    <dbReference type="KEGG" id="ovi:T265_06645"/>
    <dbReference type="CTD" id="20320824"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="16724" checksum="D99A1550865A47AF" modified="2014-10-01" version="1">MLSRRANKHQGIITLDTANKFERVTQPGCLKMFYNRRNQGDRDNYSWKVRNVWGLTARSICADICAYEGSHEILRTIFWNRIELKWTLRKIVTFLLHVHLIGSRILSTYRYALMRAQDQTSFGRPPVDPKVEKVTKLPRDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEP5</accession>
    <name>A0A075AEP5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corticotropin-releasing factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169336.1">
        <property type="nucleotide sequence ID" value="XM_009171072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEP5"/>
    <dbReference type="GeneID" id="20328071"/>
    <dbReference type="KEGG" id="ovi:T265_13904"/>
    <dbReference type="CTD" id="20328071"/>
    <dbReference type="OrthoDB" id="6248189at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705472" description="Corticotropin-releasing factor domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9562" checksum="F668615233CFAD5C" modified="2014-10-01" version="1" fragment="single">MKLQLIFLFLVVAITMGSTARDFYEYLARQEPYLNVPRRSAASKRMATEHRILELARLHRLTEKARRILEHNRFQNYGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFK8</accession>
    <name>A0A075AFK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168349.1">
        <property type="nucleotide sequence ID" value="XM_009170085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFK8"/>
    <dbReference type="GeneID" id="20319335"/>
    <dbReference type="KEGG" id="ovi:T265_05153"/>
    <dbReference type="CTD" id="20319335"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8561" checksum="CF6A012CB62B6135" modified="2014-10-01" version="1">MTAETSRRRTWAFSAYAHRAEAQTEKLTFPEAALITWFALASDIVSDVAYGTIFDTALIEDSVTVPIGNPIIFCRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG97</accession>
    <name>A0A075AG97_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167723.1">
        <property type="nucleotide sequence ID" value="XM_009169459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG97"/>
    <dbReference type="GeneID" id="20318850"/>
    <dbReference type="KEGG" id="ovi:T265_04668"/>
    <dbReference type="CTD" id="20318850"/>
    <dbReference type="OrthoDB" id="10508002at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="28249" checksum="AB51CC6551AAA6D9" modified="2014-10-01" version="1">MSKRAINGQEHLAEKLTYVLGCLNRKILDANMKETIFHHFVTGLTFLLSFDVGNSEMYGCRNTTDLVRIEVNQNKMECVRDEIDPDAEFEGVVKAIGFTGSGFTESQSDPDSERLTWDSLTTGEVYNTHPNNCAGHEENCSNGSGVNVNSTHPAANFSKFNEADSSISFTDKAESESNLYFLDVQLIGRSVFFESNKLHFNGMAKHPAASNKLCYDDDDDGDEDNGDDDDDEDNDDNDDDGDDDAGRSSIPLVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGH2</accession>
    <name>A0A075AGH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167522.1">
        <property type="nucleotide sequence ID" value="XM_009169258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGH2"/>
    <dbReference type="GeneID" id="20318685"/>
    <dbReference type="KEGG" id="ovi:T265_04503"/>
    <dbReference type="CTD" id="20318685"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12362" checksum="B1F52F008B5D0E7C" modified="2014-10-01" version="1">MAWVYIMPPENRNPMTVVPDDPYPSMAPKQLPACMRLSTDEPGPQFASKQLHRHLGLCEDTQNNYFRLVYNESKWHHYCQGTNFQKVSSKQTAYKGVEGLAAGIHGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH22</accession>
    <name>A0A075AH22_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166970.1">
        <property type="nucleotide sequence ID" value="XM_009168706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH22"/>
    <dbReference type="GeneID" id="20327565"/>
    <dbReference type="KEGG" id="ovi:T265_13398"/>
    <dbReference type="CTD" id="20327565"/>
    <dbReference type="OrthoDB" id="21443at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="266" mass="28896" checksum="A155AEE23343B1BE" modified="2014-10-01" version="1">MCGFLDDVELLPTDAKGVLKDKTGSLGCTIHRSVIKTYKEQLSNCVLLLLKQVSLFSPTGKKFYVNLTLSNIVRVYTPGQTFPALTSSRSVNQPLKNPPFSPAEFETLESECLRSNSPPVTPIPTRHSRVPNQSTSSSGVPAQHDFQPSSITLGTLETSRKPPVQKDSQINASLSSDASDYRIRPSRPSIPPSETNRNCQTPVRTGLGSLLRGSTHSVSIPEPSPDAFIRPQSFVTGPPAVDKLLNDDMDDVLSSFADESLSDIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHB4</accession>
    <name>A0A075AHB4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166671.1">
        <property type="nucleotide sequence ID" value="XM_009168407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHB4"/>
    <dbReference type="STRING" id="6198.A0A075AHB4"/>
    <dbReference type="GeneID" id="20327500"/>
    <dbReference type="KEGG" id="ovi:T265_13333"/>
    <dbReference type="CTD" id="20327500"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="541" mass="58229" checksum="9789845E09FB6B83" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHE3</accession>
    <name>A0A075AHE3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHE3"/>
    <dbReference type="GeneID" id="20317936"/>
    <dbReference type="KEGG" id="ovi:T265_03749"/>
    <dbReference type="CTD" id="20317936"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
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            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="783"/>
        </location>
    </feature>
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            <end position="304"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="679"/>
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        </location>
    </feature>
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        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="106500" checksum="43108C86575C7D69" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHZ6</accession>
    <name>A0A075AHZ6_OPIVI</name>
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        <recommendedName>
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        </recommendedName>
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    </gene>
    <organism evidence="5 6">
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER30749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="22118" checksum="4C033AA8215F3A74" modified="2014-10-01" version="1">MALAKIIKPDNKPVTPLEEEIAQAITDLQVHDEWSDAMKLLYFCEAKEMMIGREKAIVIYVPVPQLRTYQMIHNRLVGELEKKLRGPHVVLVAFRRILPKPKRKSKFNPKQKRPRSRTLTSVHDAILKDLVYPAEIVGKRTQVRCDGSTLIKCHLDVAQRNYIEHKLKTITGLYKKLTGKDVQIEFPDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ3</accession>
    <name>A0A075AIJ3_OPIVI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009166258.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075AIJ3"/>
    <dbReference type="GeneID" id="20316287"/>
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    <dbReference type="OrthoDB" id="756206at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ubl_ZFAND4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053061">
        <property type="entry name" value="AN1-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728:SF1">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
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        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="8">
        <location>
            <begin position="910"/>
            <end position="957"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="106245" checksum="CE56942010040E9E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN7</accession>
    <name>A0A075AIN7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164278.1">
        <property type="nucleotide sequence ID" value="XM_009166014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN7"/>
    <dbReference type="STRING" id="6198.A0A075AIN7"/>
    <dbReference type="GeneID" id="20316076"/>
    <dbReference type="KEGG" id="ovi:T265_01888"/>
    <dbReference type="CTD" id="20316076"/>
    <dbReference type="OrthoDB" id="6251231at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF9">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="29"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="634"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="80350" checksum="097D374E24B9F77A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIQ8</accession>
    <name>A0A075AIQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_12877</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164243.1">
        <property type="nucleotide sequence ID" value="XM_009165979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIQ8"/>
    <dbReference type="STRING" id="6198.A0A075AIQ8"/>
    <dbReference type="GeneID" id="20327045"/>
    <dbReference type="KEGG" id="ovi:T265_12877"/>
    <dbReference type="CTD" id="20327045"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="322"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="525" mass="58615" checksum="C4ECE5E03FFB2A99" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIU8</accession>
    <name>A0A075AIU8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164018.1">
        <property type="nucleotide sequence ID" value="XM_009165754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIU8"/>
    <dbReference type="GeneID" id="20315876"/>
    <dbReference type="KEGG" id="ovi:T265_01688"/>
    <dbReference type="CTD" id="20315876"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="283" mass="32608" checksum="3FF523EAE7158D70" modified="2014-10-01" version="1">MKDSEEYTHLQIYLVFTRHATESLLYDSLRLNVLHKGRFMIQLARYSRDRSIFSYRKLLEDCTDLMGETGRGLSKSFQQPCENEGFTLVSLERSVTTSWAVEEFSATLNYDCDKPRDNQFSACPLQKQLAATSKVAFSGTVLNSATCVMLKDNLSQERLDYAQVIKAIEPLLILGQKLKPRDGNGGNNGREMLPDLYRVCVLFQRNQQRGPRKMRLNRLTTERLTANLSESHNRVSSRCYLIRCEFILGQDRHQSAQRWNFCFRRGATRRTQALDIRAKSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJR2</accession>
    <name>A0A075AJR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162293.1">
        <property type="nucleotide sequence ID" value="XM_009164029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJR2"/>
    <dbReference type="STRING" id="6198.A0A075AJR2"/>
    <dbReference type="GeneID" id="20314472"/>
    <dbReference type="KEGG" id="ovi:T265_00284"/>
    <dbReference type="CTD" id="20314472"/>
    <dbReference type="OrthoDB" id="2018427at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="11">
        <location>
            <begin position="25"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="79"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="253"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="871" mass="100330" checksum="BC7D4932B9CA1689" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTM8</accession>
    <name>A0A074YTM8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL612223">
        <property type="protein sequence ID" value="KER18083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178170.1">
        <property type="nucleotide sequence ID" value="XM_009179906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTM8"/>
    <dbReference type="STRING" id="6198.A0A074YTM8"/>
    <dbReference type="GeneID" id="20330470"/>
    <dbReference type="KEGG" id="ovi:T265_16305"/>
    <dbReference type="CTD" id="20330470"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="6529" checksum="7A9605AE861B845A" modified="2014-10-01" version="1" fragment="single">MFVHTPVVNQQVAGGDSSNKLVDLGNGEASPVKEPVLGYLAKHARKICLAAKPAPLIQSSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTQ6</accession>
    <name>A0A074YTQ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL608621">
        <property type="protein sequence ID" value="KER18151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178102.1">
        <property type="nucleotide sequence ID" value="XM_009179838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTQ6"/>
    <dbReference type="GeneID" id="20326526"/>
    <dbReference type="KEGG" id="ovi:T265_12358"/>
    <dbReference type="CTD" id="20326526"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8231" checksum="BED8A294C607D463" modified="2014-10-01" version="1">MTFDFGFKDPQVNPTLLRPFHQSSRSRLRCLWHSSIELRIQGCKLLDSEQYPARRLIPGREKNNTSLESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUR3</accession>
    <name>A0A074YUR3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600315">
        <property type="protein sequence ID" value="KER18521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177732.1">
        <property type="nucleotide sequence ID" value="XM_009179468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUR3"/>
    <dbReference type="GeneID" id="20326413"/>
    <dbReference type="KEGG" id="ovi:T265_12245"/>
    <dbReference type="CTD" id="20326413"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13382" checksum="00B07ADAB3234410" modified="2014-10-01" version="1">MEVRKSSVVSRAFFGSAESKVTLRLLTISDIPPDKTTPPMVAHLSWPGAEKYPPFTLERHLADFVGLYPRLVTNDSLIRARGLFRKLIATSTVCIFALTLWVSPEQSRSPQFPSDLPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWB6</accession>
    <name>A0A074YWB6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597352">
        <property type="protein sequence ID" value="KER19066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177187.1">
        <property type="nucleotide sequence ID" value="XM_009178923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWB6"/>
    <dbReference type="GeneID" id="20326195"/>
    <dbReference type="KEGG" id="ovi:T265_12027"/>
    <dbReference type="CTD" id="20326195"/>
    <dbReference type="OrthoDB" id="6277134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="363" mass="39909" checksum="5931234DF98676D2" modified="2014-10-01" version="1">MSASASAPTGSKKANSCKFKIPVNQPPPIDMVKASINAAKDREGTSLPTIKEFIAANYNFETWPAHPSGHRSRRRESCPRSRRDFNQIISATLVSCCERTRNVSQECKIPIAWLVPSNPAPMMLPRLMMERLPSNCQARRTDQKPSSAPELPTFHNTANIDCSPRKPMPLDGTLDGENSGNSEVTSGSTKEFQCDLVPLDAAKSLNGTWKATVDPTEAASVTTLEADNSVKIGPPDVQGYRDQPSSFNVSCTFSTPEGVALYNFERTVTVKRKRYLNLLTQHESQSSDCLEKGELMFHVTCRGVNTHLQKQNLVLRLESVGIALRIGIVPHQSGPCVFLQSALPTESMFLLSVTINDKYANND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWG0</accession>
    <name>A0A074YWG0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597378">
        <property type="protein sequence ID" value="KER19018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177234.1">
        <property type="nucleotide sequence ID" value="XM_009178970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWG0"/>
    <dbReference type="GeneID" id="20329863"/>
    <dbReference type="KEGG" id="ovi:T265_15698"/>
    <dbReference type="CTD" id="20329863"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16481" checksum="1799C168E3C1E741" modified="2014-10-01" version="1" fragment="single">PADRVRILSKLCQNGLRLHNGELYDRIQQRLILGECVQSQTHSCPEANVVGMTKSVLAERLVASRLAMQLPFFLHVSNVSSSFRKAIKFYGILYRVKNVLRQRGGGASGPGAAPEPLATLQSLVNRDAASVEELQTRVNQLTEEIPAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZM1</accession>
    <name>A0A074YZM1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597078">
        <property type="protein sequence ID" value="KER20211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176038.1">
        <property type="nucleotide sequence ID" value="XM_009177774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZM1"/>
    <dbReference type="STRING" id="6198.A0A074YZM1"/>
    <dbReference type="GeneID" id="20325350"/>
    <dbReference type="KEGG" id="ovi:T265_11182"/>
    <dbReference type="CTD" id="20325350"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF75">
        <property type="entry name" value="AURORA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="280"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="869" mass="97362" checksum="F6EF040FE3E2A0C9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z069</accession>
    <name>A0A074Z069_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597068">
        <property type="protein sequence ID" value="KER20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175929.1">
        <property type="nucleotide sequence ID" value="XM_009177665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z069"/>
    <dbReference type="GeneID" id="20325268"/>
    <dbReference type="KEGG" id="ovi:T265_11100"/>
    <dbReference type="CTD" id="20325268"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="267" mass="29128" checksum="4A005F706036130A" modified="2014-10-01" version="1">MQYPKVTENSSTSHASTSTTGFALLGAHQLKLDLFVYRQPCHSSGYLPSLAVGLQTSYHQSRWDCQCELTASFALVIKCLQSNCQVQQTGQQRTSVTEFSTVFNTIANPVHLPCSTPMRLGQPGSIPALVLPSGSMAARHRKGVTAERFFFISTECAATGRLMFQWLDTSKFLVHDAPIIHPDFDVYLPAKSDSQCLSPVTSTASKPVVPQCSIFSQAWGEMAQLLERKFIDRKVRGLNTTSVCRLPLSTPGQFGNIPALLQPSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0H1</accession>
    <name>A0A074Z0H1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597415">
        <property type="protein sequence ID" value="KER18972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177281.1">
        <property type="nucleotide sequence ID" value="XM_009179017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0H1"/>
    <dbReference type="GeneID" id="20329887"/>
    <dbReference type="KEGG" id="ovi:T265_15722"/>
    <dbReference type="CTD" id="20329887"/>
    <dbReference type="OrthoDB" id="10550043at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15807" checksum="3D382EBDA9CB2FCA" modified="2014-10-01" version="1" fragment="single">DKLEVYLRDLQEKVGEFLKQLGASLNETARKLKNADDQTKQSLSDMLLQTLKHLEDVYETFLVLLQTEQIKSYLSDLLGSISSWISSYDGDKMQAKGIGAVHVLKTLQQIQGYLKQELPKLVGMCFASSISVSYLKVYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0U9</accession>
    <name>A0A074Z0U9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597040">
        <property type="protein sequence ID" value="KER20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175659.1">
        <property type="nucleotide sequence ID" value="XM_009177395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0U9"/>
    <dbReference type="GeneID" id="20329449"/>
    <dbReference type="KEGG" id="ovi:T265_15284"/>
    <dbReference type="CTD" id="20329449"/>
    <dbReference type="OrthoDB" id="6579237at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="801" mass="90070" checksum="8CBDDA67CE196633" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0X8</accession>
    <name>A0A074Z0X8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597033">
        <property type="protein sequence ID" value="KER20666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175587.1">
        <property type="nucleotide sequence ID" value="XM_009177323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0X8"/>
    <dbReference type="GeneID" id="20325006"/>
    <dbReference type="KEGG" id="ovi:T265_10838"/>
    <dbReference type="CTD" id="20325006"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12625" checksum="E0F86FF2CB096C66" modified="2014-10-01" version="1">MPCMSKHIESNVVQRFAKDETQEYCTCTQSTVPVNETTGCCISDIHQRKVSRVTDNNKSRISTTASHSPTSFERASGLHKHNSSANMRIRSPSGNLFVVISPTTHNYVQLDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z200</accession>
    <name>A0A074Z200_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597003">
        <property type="protein sequence ID" value="KER21008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175260.1">
        <property type="nucleotide sequence ID" value="XM_009176996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z200"/>
    <dbReference type="GeneID" id="20324749"/>
    <dbReference type="KEGG" id="ovi:T265_10581"/>
    <dbReference type="CTD" id="20324749"/>
    <dbReference type="OrthoDB" id="6137646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="18180" checksum="3D6CA71AF7E79B18" modified="2014-10-01" version="1">MEVRQPHLRLIRPGSYAPADLNVQSKMQVDFWRNVKIEGEITVSLGVCSLFTSVNLSTATLAVATVLNNQMAMNGPLGRERTCELPDLGLTTYFEFDGEYYEQLKIVPMGSPVSDFIMEVVTRQMERTVLPNIRPNVRMRYLNDTLVNVMENEQPRANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z427</accession>
    <name>A0A074Z427_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KL596937">
        <property type="protein sequence ID" value="KER21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174422.1">
        <property type="nucleotide sequence ID" value="XM_009176158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z427"/>
    <dbReference type="STRING" id="6198.A0A074Z427"/>
    <dbReference type="GeneID" id="20324102"/>
    <dbReference type="KEGG" id="ovi:T265_09934"/>
    <dbReference type="CTD" id="20324102"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19537" checksum="71DC9BAC8DDFCFB8" modified="2014-10-01" version="1">MLRSILSTAPNFTGECVHNGTKTTVESAYFTGKYTIILFYPSNFVQCTAEELLALDQSLSEFERLNCTLLAITPDSIESQIAWYRAPLESNGLGGGVRFPLLSDKSFSVCRAYGVLREDKGVPLRSLFILDPLQKIRVVLSMDIGIMYDISEILRIIKYLTDLDNRASQNAAKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z467</accession>
    <name>A0A074Z467_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174367.1">
        <property type="nucleotide sequence ID" value="XM_009176103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z467"/>
    <dbReference type="STRING" id="6198.A0A074Z467"/>
    <dbReference type="GeneID" id="20324059"/>
    <dbReference type="KEGG" id="ovi:T265_09891"/>
    <dbReference type="CTD" id="20324059"/>
    <dbReference type="OrthoDB" id="6274309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="PAS fold-3" evidence="3">
        <location>
            <begin position="495"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1108" mass="122025" checksum="E409275FAA21C111" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z508</accession>
    <name>A0A074Z508_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174098.1">
        <property type="nucleotide sequence ID" value="XM_009175834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z508"/>
    <dbReference type="GeneID" id="20323847"/>
    <dbReference type="KEGG" id="ovi:T265_09679"/>
    <dbReference type="CTD" id="20323847"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="438" mass="49690" checksum="B50607A7F23E42FA" modified="2014-10-01" version="1">MFYLNPDCTKLAKCTHLQTNLVFPKTHLEPTRITRLGCFQATECAAMGHLSPLMVDYNEDNIHGAAFWLLHVFHDCPWTWSAWLTPCPLRARESVCLDWVRFAFIAYPKAVPGFEPLISGMRGERVTTTLTIDNFTPLQIHLVSTKDSIESLVYDILQLNVLHKGLLMIQLARYSRYRSRQPESRECQRKERPQPCCCPLAVEELDTSLSRRRLSAPSSERSNHSCADAPTYTQTDPHIGKSNTVSTLRIARAQGARSQLLHESTDNYGTRVAVALRRKTRSRHPDFHQGTLTDDKKLLTRLLKTLRQPTTGFRPSWGSSGRRSPRVSVNLMFYLKPNWTVFEKYTHSCMIVTWSVTNGPVRRGNSGDMRQALHAIGCDIDFLVHQPVIISYRGICFPQSAKAVIGLGLPKVTVRDLCLLAIVGSLRTYDTFMRGTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z599</accession>
    <name>A0A074Z599_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596909">
        <property type="protein sequence ID" value="KER22248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173999.1">
        <property type="nucleotide sequence ID" value="XM_009175735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z599"/>
    <dbReference type="STRING" id="6198.A0A074Z599"/>
    <dbReference type="GeneID" id="20323782"/>
    <dbReference type="KEGG" id="ovi:T265_09614"/>
    <dbReference type="CTD" id="20323782"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10481" checksum="7BA43A39A7415EE8" modified="2014-10-01" version="1">MCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNNLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQASLMELDDNLKYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5D3</accession>
    <name>A0A074Z5D3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596904">
        <property type="protein sequence ID" value="KER22341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173904.1">
        <property type="nucleotide sequence ID" value="XM_009175640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5D3"/>
    <dbReference type="GeneID" id="20329044"/>
    <dbReference type="KEGG" id="ovi:T265_14878"/>
    <dbReference type="CTD" id="20329044"/>
    <dbReference type="OrthoDB" id="6232533at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703923" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8338" checksum="32EEA44DFE4332B7" modified="2014-10-01" version="1">MTMTKAWLIFSLSVVAVLFSQPADALVRLAPANVDYGDLHSVKRWIDFKKRAWSDFKRNAAFGYPEDRPEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5Y5</accession>
    <name>A0A074Z5Y5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596892">
        <property type="protein sequence ID" value="KER22556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173694.1">
        <property type="nucleotide sequence ID" value="XM_009175430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5Y5"/>
    <dbReference type="STRING" id="6198.A0A074Z5Y5"/>
    <dbReference type="GeneID" id="20323555"/>
    <dbReference type="KEGG" id="ovi:T265_09386"/>
    <dbReference type="CTD" id="20323555"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="20658" checksum="2C63F65C52280F7A" modified="2014-10-01" version="1">MFCTHDYVVDVGKVCNDVEHFVPYQVKTPGGRIVYIYIKKRGTVPKCGDCKTKLPGIKPSRPRERCTMSKRLKTVNRAYGGTRCHKCVRNRLWSWHGARRPKWLEREFTDRKVRGSNPPSATRLPLSRLGQPGGIPALVLPSGNMAARHRKGATAERFLSAILSFANADEPVGFYGPTHSAAPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z618</accession>
    <name>A0A074Z618_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597003">
        <property type="protein sequence ID" value="KER20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175249.1">
        <property type="nucleotide sequence ID" value="XM_009176985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z618"/>
    <dbReference type="GeneID" id="20324743"/>
    <dbReference type="KEGG" id="ovi:T265_10575"/>
    <dbReference type="CTD" id="20324743"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10374" checksum="499A39B2EA508E42" modified="2014-10-01" version="1">MPHGAYVRPLLEYPNQVVYSGRTKYAIPVSRIHGLIHRIEAFAQVSRVGFVLVASLFRRPAATKMVSGLKFVDCDTRLATLELFPLKYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z646</accession>
    <name>A0A074Z646_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175218.1">
        <property type="nucleotide sequence ID" value="XM_009176954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z646"/>
    <dbReference type="GeneID" id="20324720"/>
    <dbReference type="KEGG" id="ovi:T265_10552"/>
    <dbReference type="CTD" id="20324720"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6385" checksum="94BAA50ECE81EC14" modified="2014-10-01" version="1">MDKTRAATTNASGVQMNSGNPHIDLQRIANECSADNASIVRSDQSNPGQLFVALSYDFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6P8</accession>
    <name>A0A074Z6P8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596882">
        <property type="protein sequence ID" value="KER22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173505.1">
        <property type="nucleotide sequence ID" value="XM_009175241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6P8"/>
    <dbReference type="GeneID" id="20323401"/>
    <dbReference type="KEGG" id="ovi:T265_09222"/>
    <dbReference type="CTD" id="20323401"/>
    <dbReference type="OrthoDB" id="10493618at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="16673" checksum="44F1B934EC46A127" modified="2014-10-01" version="1">MVDELTRIVFWSLFQTRPKAATLTWWSGFSAAMILRATLAGASFHKVQPCQEGQRGAARPRTTSNRATRRFGADNDDAKMNESLPNAPPSDTNSYWRLPPAVITADNDDAKMNESLPNAPPSDTNSYWNEIATSLHSVGNLACGTALPGALKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z790</accession>
    <name>A0A074Z790_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596967">
        <property type="protein sequence ID" value="KER21447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174816.1">
        <property type="nucleotide sequence ID" value="XM_009176552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z790"/>
    <dbReference type="GeneID" id="20329261"/>
    <dbReference type="KEGG" id="ovi:T265_15095"/>
    <dbReference type="CTD" id="20329261"/>
    <dbReference type="OrthoDB" id="6219854at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704949" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7668" checksum="9F6387786E6D9CF5" modified="2014-10-01" version="1">MNVQLFIVFTMCFLTITGGQAVEVERTNWMARERICSQCWKYCSDATEEDFLLGLPVKRRDRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L9</accession>
    <name>A0A074Z7L9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173088.1">
        <property type="nucleotide sequence ID" value="XM_009174824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L9"/>
    <dbReference type="GeneID" id="20323075"/>
    <dbReference type="KEGG" id="ovi:T265_08896"/>
    <dbReference type="CTD" id="20323075"/>
    <dbReference type="OrthoDB" id="9378527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50935" checksum="06F5011170E98914" modified="2014-10-01" version="1">MRPEVAPRKMDWAAAKEVLAAEFDTPADRQEAMRRFKTARMAPGSDPTVFFAGLQQLLDRALTTLDGVSRHQLLSDQSVEGVQPAIGVQLRLARATGQLSVEELVRLARELPEAPLATMQSPENRDGSSVEELQTRVDQLTEQLAVVKTESWRHARTSRRYMCEEFGKQIGLNFSYISPFMDASASFIQRPQTLEQAQQHSVSNGFHPNCQQSSSKPITLPCSPSPGQQPRQNVDPVHQPMVFQDISASTSQQQKAEQRLQPSTIDDSLSSVPHNSGGSSHLSTDTTAPSSTVHPGQTVSSEPVSNNVPHSDSNSPVNGVRPSSGIPRLRPSAIPRLVNPRVDDSVHILERASSIGNASPHRTASSCASPCDKPHDGPISLPQTPSGAFTRPFLHITQSPVEPSSPPNNDQHVGSYYADRSRTSSRPANACRVERTASEHPQRPADNESDTSSVSLFLVSAPTTSYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7N0</accession>
    <name>A0A074Z7N0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173121.1">
        <property type="nucleotide sequence ID" value="XM_009174857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7N0"/>
    <dbReference type="GeneID" id="20323097"/>
    <dbReference type="KEGG" id="ovi:T265_08918"/>
    <dbReference type="CTD" id="20323097"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7139" checksum="04CB44EA32DBAB09" modified="2014-10-01" version="1">MKMSRGGGCAIYSKCPVLPVLNPTVSEVTRFLLSTVCSSMSLSIMLFNARSLLPKIHNIRAILAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8D4</accession>
    <name>A0A074Z8D4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172877.1">
        <property type="nucleotide sequence ID" value="XM_009174613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8D4"/>
    <dbReference type="GeneID" id="20328816"/>
    <dbReference type="KEGG" id="ovi:T265_14650"/>
    <dbReference type="CTD" id="20328816"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="317" mass="35543" checksum="F59C6593B1D65ED5" modified="2014-10-01" version="1" fragment="single">WARWPKWLEREFTDRKVRGSNPTSATRLPLSRPGQPGSILALVLPFGWNASRPRAGDMDILTEQLKTSGCSTNPTKSVIARTPVASDWCIPESQGTCGSSHGGTLLLYGCETWPVRVAELRFLQVSDIRYLRTIARVGWCRRIRNEAVRKRVFGCVTGTSIEECVQHQKLRWLGHVLRPEGARWLKWLEREFTDRKVRSNPNSASRLPLSKLGQPGSIPALVLPSSSMAARHRKGVTAKRNKWSNLPTRKSGVRTPPLPLDFPYIDLGNLAVSQPSCNLWVAWQLGTEKLLQLNDFFTCAILTDVASTNSEPQIYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA09</accession>
    <name>A0A074ZA09_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596823">
        <property type="protein sequence ID" value="KER24091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172169.1">
        <property type="nucleotide sequence ID" value="XM_009173905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA09"/>
    <dbReference type="GeneID" id="20322359"/>
    <dbReference type="KEGG" id="ovi:T265_08180"/>
    <dbReference type="CTD" id="20322359"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7766" checksum="17EE658E33549FC5" modified="2014-10-01" version="1">MDQELSPNREGFRLISSQLKLLKEATHLWDVCTAEVSNPHLRFRISGPVADVIKRQLTVVTMSQWSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAS3</accession>
    <name>A0A074ZAS3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597066">
        <property type="protein sequence ID" value="KER20335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175912.1">
        <property type="nucleotide sequence ID" value="XM_009177648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAS3"/>
    <dbReference type="GeneID" id="20325253"/>
    <dbReference type="KEGG" id="ovi:T265_11085"/>
    <dbReference type="CTD" id="20325253"/>
    <dbReference type="OrthoDB" id="6284325at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15140" checksum="BDD9EEAB37A72599" modified="2014-10-01" version="1">MTGGANVQMPMFAINRSAKTLNMDTVVQAEDSSAASSRTHAGYFQINTPGNRKYLTVTVNGHPVRLQLDTWSDITIISEKLWRTLGQPLIRQAARTATSACGGELKLSGRDFAGFTELATFGRSEMRDSQVSLNKESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB24</accession>
    <name>A0A074ZB24_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMS membrane protein/tumor differentially expressed protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171782.1">
        <property type="nucleotide sequence ID" value="XM_009173518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB24"/>
    <dbReference type="GeneID" id="20328583"/>
    <dbReference type="KEGG" id="ovi:T265_14417"/>
    <dbReference type="CTD" id="20328583"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51880" checksum="4271A548B0E9A31F" modified="2014-10-01" version="1" fragment="single">MTCIYRKLKCAFSGEPCFVCCLKNLKESTTTRLSYSVILIVVVVLSTASHEGGLMGMLHSKVTVFGQFSLRYFQYKSELSSLCSLLHAGENCTRFSGYIGIYRLCLPLFLFHTVMALLTVGVSSSQTLRGRIHNGFWAWKVLMLLGLYICAYLFPTLEELVFVWMILGIIGGLIFIYVQHITLIDFAYELNGIWHAKSRKCMWYTFLIYLCTIVLYLATVAAYTLFIISYGLPKQCSLNLTMTGINGGLTGLFAICSIFSNTLQKKQLWLPGAVTSAFVAFLTWSALNSQPAILTSDVPWQKRLGFSVDKQQNLTVHPLLVVADHLNRLLSDQVSTESPSAAKSITSPVSTIMLNQCLPGGIGSVASHVGKDIFTFLGLVLVIGWSLYSSVDKQQNLTVHPLLVVADHLNRLLSDQVSTESPSAAKSITSPVSTIMLNQCLPGGIGSVASHVGKDIFTFLGLVLVIGWSLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB65</accession>
    <name>A0A074ZB65_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597053">
        <property type="protein sequence ID" value="KER20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175779.1">
        <property type="nucleotide sequence ID" value="XM_009177515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB65"/>
    <dbReference type="STRING" id="6198.A0A074ZB65"/>
    <dbReference type="GeneID" id="20329475"/>
    <dbReference type="KEGG" id="ovi:T265_15310"/>
    <dbReference type="CTD" id="20329475"/>
    <dbReference type="OrthoDB" id="6600601at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="11"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="270" mass="30284" checksum="9022CFB1F0FDA063" modified="2014-10-01" version="1" fragment="single">IPLWRSCGRYYCGLLSLGTPTQQFKVLFDTGSCNTWVRSVNSKTQFTSKAYDWKSSKSAVIEKNEQTMEYANCHITGMVVKDRVTLGNKTTNIRFASGVERSQSCPRKRSFDGIVGLCAVPGEMAFLNQLFEQDIINERIFSMWINPNTREPLAGLVILGGVYDGLYSGNLSKVPLEPLRKWWCFKLTGVRIDDGKAIPLAYLVAVDSGATKIWVPESVLKQINHVLQPIGFDGKYHLVDCSKIPKKPIVHLEAGQLKLSMEPKYCIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBS1</accession>
    <name>A0A074ZBS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_15266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597035">
        <property type="protein sequence ID" value="KER20645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175604.1">
        <property type="nucleotide sequence ID" value="XM_009177340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBS1"/>
    <dbReference type="STRING" id="6198.A0A074ZBS1"/>
    <dbReference type="GeneID" id="20329431"/>
    <dbReference type="KEGG" id="ovi:T265_15266"/>
    <dbReference type="CTD" id="20329431"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="83"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27123" checksum="6B3775B6577324B8" modified="2014-10-01" version="1" fragment="single">MSLIFHHNIPWSLITDQLMGCSCAADECQDKCTCRSRSGESYTKDGRLLDFRHPVFECNSACTCSSSCSNRVVQRHLSAVQSAGHMIYRITERCGVGQCLNAARNFEPGELVCVYLGEVIPYTEACRREAKQLEKYGHNYVLILRCFAGASLVSEVCVDGNSFGPNGSPPVARLVNHSCDPNLTLVPVHVDSVIPYVCMFANRSIPCGTELTYNYADCVPVDQVSSSSVPCLCNSSNCRGYLPRVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC63</accession>
    <name>A0A074ZC63_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173120.1">
        <property type="nucleotide sequence ID" value="XM_009174856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC63"/>
    <dbReference type="GeneID" id="20328872"/>
    <dbReference type="KEGG" id="ovi:T265_14706"/>
    <dbReference type="CTD" id="20328872"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="9007" checksum="BAC9F8AA2A2768AC" modified="2014-10-01" version="1" fragment="single">FIKETTHKVAEISSTAHDRFRPSWSSSGRRILRVSVNLMIVDIVQSEHCRFVPVVDWPSARFTSHNFLCSTEEASTCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCK5</accession>
    <name>A0A074ZCK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171199.1">
        <property type="nucleotide sequence ID" value="XM_009172935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCK5"/>
    <dbReference type="GeneID" id="20321596"/>
    <dbReference type="KEGG" id="ovi:T265_07417"/>
    <dbReference type="CTD" id="20321596"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12976" checksum="ED9E8DDB87D42CCB" modified="2014-10-01" version="1">MYGLINYPEVYVNHKGPKSCVQNLVGSSTVVDIFGSHHVLCQLTQERDLGVPDFTLLLFPDTYTLYPNGNKSSVVFLARNHLTLFQRSGVINYGLLFEHHRDTEHQAVILGGASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCL2</accession>
    <name>A0A074ZCL2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171336.1">
        <property type="nucleotide sequence ID" value="XM_009173072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCL2"/>
    <dbReference type="GeneID" id="20321706"/>
    <dbReference type="KEGG" id="ovi:T265_07527"/>
    <dbReference type="CTD" id="20321706"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704040" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
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                <person name="Maleewong W."/>
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                <person name="Tan P."/>
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                <person name="Gasser R.B."/>
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            <dbReference type="EMBL" id="KER23452.1"/>
        </source>
    </evidence>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
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                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
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                <person name="Tan P."/>
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    </evidence>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGN8</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596900">
        <property type="protein sequence ID" value="KER22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173835.1">
        <property type="nucleotide sequence ID" value="XM_009175571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGN8"/>
    <dbReference type="GeneID" id="20323658"/>
    <dbReference type="KEGG" id="ovi:T265_09489"/>
    <dbReference type="CTD" id="20323658"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22138" checksum="B652AC6D1C4DC9AF" modified="2014-10-01" version="1">MMFSGPFSPCIKKAFAEPPPNDIWTHFSLFRGRCQSTDHCSAASTSVWRALALELQDFNSSAKGRHGLTRVCVAAGRGTLSRVPGDRRLRGELILTYALFEQSLANRLWCKHQDVRRRLTPVLESAHALSIKRCGPLQYTCPLYMKICPFQAVRTILHAFFSLIPTPPTVAFGLQPIGKSCALTIVPKPPPTDFDGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHF5</accession>
    <name>A0A074ZHF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173600.1">
        <property type="nucleotide sequence ID" value="XM_009175336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHF5"/>
    <dbReference type="STRING" id="6198.A0A074ZHF5"/>
    <dbReference type="GeneID" id="20323480"/>
    <dbReference type="KEGG" id="ovi:T265_09307"/>
    <dbReference type="CTD" id="20323480"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="14016" checksum="08B7BA512269439C" modified="2014-10-01" version="1">MDEFMAFRDEEIEEIFRQIDKNKNGKIDKRELQAFFKKHDKKFTAKQVTDYIKNLAYIKDLLKTADKNKDNKLSREEMREFIETLTCPKLKAKCQEFLEKQTEEVDLEELASWLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP8</accession>
    <name>A0A074ZHP8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596880">
        <property type="protein sequence ID" value="KER22780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173463.1">
        <property type="nucleotide sequence ID" value="XM_009175199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP8"/>
    <dbReference type="STRING" id="6198.A0A074ZHP8"/>
    <dbReference type="GeneID" id="20323366"/>
    <dbReference type="KEGG" id="ovi:T265_09187"/>
    <dbReference type="CTD" id="20323366"/>
    <dbReference type="OrthoDB" id="5860246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041384">
        <property type="entry name" value="DNTTIP1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026064">
        <property type="entry name" value="TdIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049121">
        <property type="entry name" value="TdIF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23399:SF2">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18192">
        <property type="entry name" value="DNTTIP1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21229">
        <property type="entry name" value="TdIF1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNTTIP1 dimerisation" evidence="5">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="TdIF1 C-terminal" evidence="6">
        <location>
            <begin position="814"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118785" checksum="AE255AD77ACF9BC8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIJ4</accession>
    <name>A0A074ZIJ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_06018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169441.1">
        <property type="nucleotide sequence ID" value="XM_009171177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIJ4"/>
    <dbReference type="STRING" id="6198.A0A074ZIJ4"/>
    <dbReference type="GeneID" id="20320200"/>
    <dbReference type="KEGG" id="ovi:T265_06018"/>
    <dbReference type="CTD" id="20320200"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="963"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER26806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113730" checksum="3AF81C9970997A0F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ71</accession>
    <name>A0A074ZJ71_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172869.1">
        <property type="nucleotide sequence ID" value="XM_009174605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ71"/>
    <dbReference type="GeneID" id="20322904"/>
    <dbReference type="KEGG" id="ovi:T265_08725"/>
    <dbReference type="CTD" id="20322904"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37763" checksum="973DAC6B113AEABD" modified="2014-10-01" version="1">MSRVWVPRVVENPMVVVNTCTIRSTLTQPADLPERTEPRADVASNVCRTIIAYFFTGRRSRGGERCTRFTVSGLDCVSRAGTSAPKSTVKSATNIHIDIESCRENPMTTENVVLSACSSGPPKPCPIEKRLARFKVQPSAKTWLSGVLQIVIPLDGAMQCASNLAGLYRRTLPVPDNWGESMVMPIYKKDLIPFRSLAALPPEGSTRAAILPSCLSLDRENREAEVAFKPITFCLMVTRENLTHEDQPGIRQGRGYVEHNLILRHMHGRPTILVFLSFKDAFGSVVRPAIELYLLNRPLTDKNKTNPGNLGKSLDPVCQSVNPCRSNKGSLKKRNRSSLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ82</accession>
    <name>A0A074ZJ82_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169206.1">
        <property type="nucleotide sequence ID" value="XM_009170942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ82"/>
    <dbReference type="STRING" id="6198.A0A074ZJ82"/>
    <dbReference type="GeneID" id="20328041"/>
    <dbReference type="KEGG" id="ovi:T265_13874"/>
    <dbReference type="CTD" id="20328041"/>
    <dbReference type="OrthoDB" id="442428at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012008">
        <property type="entry name" value="Ser/Thr-Pase_EF-hand_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE RDGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000912">
        <property type="entry name" value="PPEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="790" mass="89196" checksum="0339A6A2A02975A5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJS3</accession>
    <name>A0A074ZJS3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170188.1">
        <property type="nucleotide sequence ID" value="XM_009171924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJS3"/>
    <dbReference type="GeneID" id="20320790"/>
    <dbReference type="KEGG" id="ovi:T265_06611"/>
    <dbReference type="CTD" id="20320790"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="183" mass="20492" checksum="CBCAE28695906962" modified="2014-10-01" version="1">MYQAYQDLPVDNNQRNNGSKRIDSHHRNGRDHLTKASVHKHIADHRSAQGTGRKNNPPEQRGPSLLCLRRALIYDKCAWAPTCSPTFTIRTSDWLVTQLRTFGSRIKPASQSGYTATASVLDLDNSATSAQMQDRKPCRPAIRKPTYLFYTHARPSKWTWILLTSKSPSCCADIGRASVAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI1</accession>
    <name>A0A074ZKI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP-ribosylation factor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_05196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168404.1">
        <property type="nucleotide sequence ID" value="XM_009170140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI1"/>
    <dbReference type="STRING" id="6198.A0A074ZKI1"/>
    <dbReference type="GeneID" id="20319378"/>
    <dbReference type="KEGG" id="ovi:T265_05196"/>
    <dbReference type="CTD" id="20319378"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22930" checksum="03FBB8911F8CECF2" modified="2014-10-01" version="1">MGQMFSNLFNRLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGWSDLVNLICVGLIFVVDSNDYERIGEAREELSRMLNEDELRDAVLLVFANKQIYFAIHRIYHRRCLQQMSRISSGFTPSGIVLGSSKQHALRMELVSMRALIGSVTLSATAVECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLB3</accession>
    <name>A0A074ZLB3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169692.1">
        <property type="nucleotide sequence ID" value="XM_009171428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLB3"/>
    <dbReference type="STRING" id="6198.A0A074ZLB3"/>
    <dbReference type="GeneID" id="20320402"/>
    <dbReference type="KEGG" id="ovi:T265_06220"/>
    <dbReference type="CTD" id="20320402"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22384">
        <property type="entry name" value="KH-I_KHDRBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="344" mass="37390" checksum="13ED3DDBE277EB54" modified="2014-10-01" version="1">MMKVGEPRPEQAGAIEAIVRELKNLDEKAFPALHALAENELFRLRGGIAESIDIVSNRQVKIRAKIEIPSSQYPGVNFVGKLLGPGGQTLRATQESTKTKMAILGAGSLRDDSKERELLSSGDPKYQHLKQKLHLQVDSLAPPSEAYYRLSHALAELRKVMLPESNECPPPPWVPQGTSPMVGSRGGGQFRGGRSPNPRGGFHVPPPSSPYRGRGKPWVSRGGPTNGSPMISSTPPVAPDVYGNGTTAPVYPTMNMYEQPDYSTNVYEEFGSNYGQDDSWGKVGLTDARGRGRAHPPACNYQFEFGGAQVPDNHSVEVPCTADLFTVVQQPSVMVVINRLEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLP1</accession>
    <name>A0A074ZLP1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168256.1">
        <property type="nucleotide sequence ID" value="XM_009169992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLP1"/>
    <dbReference type="STRING" id="6198.A0A074ZLP1"/>
    <dbReference type="GeneID" id="20327844"/>
    <dbReference type="KEGG" id="ovi:T265_13677"/>
    <dbReference type="CTD" id="20327844"/>
    <dbReference type="OrthoDB" id="10068977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27300" checksum="928B26A32B8C3B4A" modified="2014-10-01" version="1" fragment="single">VTSVRHPAPTSSGISKSISKLRHPVYQAAFNIHTLKQAGEQAALALTLDSLGTDVCCVSETRIQDASTVVELTTPSLSTRFRLRISGDAEAAAVGYAPQVCTVPSHRAEVSLLDWIPVHNRPYALRLAKPKRPVPFAALATVENELVRLQQSGVIQPVNHSSWAAPTVVIKKANGKVRICADYSTGLNAVLDSHQYPLPVPEDLFTKLNGGRCFAKLDLADAYLQIEVSDDSKELLTINTHRGFNLTVCRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMA8</accession>
    <name>A0A074ZMA8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167719.1">
        <property type="nucleotide sequence ID" value="XM_009169455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMA8"/>
    <dbReference type="GeneID" id="20318846"/>
    <dbReference type="KEGG" id="ovi:T265_04664"/>
    <dbReference type="CTD" id="20318846"/>
    <dbReference type="OrthoDB" id="6261743at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="394" mass="42740" checksum="EDBA6FBBDA2BE042" modified="2014-10-01" version="1">MSEELSFEQLSVSSNDSWALLDVEEPATATAPGSVDLFVIDRLDKDICFICNQPLSASRFPCPSCDICLICAQCMETYDPHRAPVCCHTFPTDAEVPMFYFDDSQGEDVLIMNPLKEVHPVSCVSEPDRLTTSTEVIQSSHATPDSNILDSKLHADTKDPLCLRDSDYRSLTDHVREALKLHTTEADIDDKSVVATAPENAVEVQTAVPGGPQMKLILSPKLWSQSDSLSSNLSSSSNSNNNGIPVPRISATPVLRTAIQVIRGSCNASECHTSSSSCSSRSPPSLSSSPLNVAGKILKSVALHSASAMNPFDCMPMDALDVNPVITKRTESRASPEYQPGTPPSSVVTGTDDRITNAKDFVSRFVWDNEKVQALIKPRPIPKSVLDQSAYNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMJ9</accession>
    <name>A0A074ZMJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596804">
        <property type="protein sequence ID" value="KER24585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171672.1">
        <property type="nucleotide sequence ID" value="XM_009173408.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZMJ9"/>
    <dbReference type="GeneID" id="20328547"/>
    <dbReference type="KEGG" id="ovi:T265_14381"/>
    <dbReference type="CTD" id="20328547"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="341"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="681"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1442" mass="162054" checksum="8306E55CE9D9ADCB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMV2</accession>
    <name>A0A074ZMV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_04491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167510.1">
        <property type="nucleotide sequence ID" value="XM_009169246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMV2"/>
    <dbReference type="STRING" id="6198.A0A074ZMV2"/>
    <dbReference type="GeneID" id="20318673"/>
    <dbReference type="KEGG" id="ovi:T265_04491"/>
    <dbReference type="CTD" id="20318673"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="362" mass="39745" checksum="0B4231A6AD223A60" modified="2014-10-01" version="1">MVPGLTTTVDQHKLSSLPSDGVTAVQFQPGKATPQFLVASSWDCTVRIYDVASGSQRMMYQHSTPVLDTTFSDTVHVLSGALRGDLKLFDCNTNQSQQLGSCTRAISTMHYNPTIQACITGSWDCTVRMWDPRASSSSNNALGDKGGAMSVHRQPNTVYTMDSIRHNLVVGTAGRHVLIWDLRQMHAPVEQRESSLRYQTRCIRCFPNGQGYILGSIEGRIAVEMFDPSPEAQKKKYAFKCHRVKEENMEIIYPVTAIAFHQGYNTFATGGCDGIVNIWDGFNRKRLAQLAKYPTSISSLAFSEDGHQLAIASSYMYERGQIEDEPEPTIYVRSVADNEVKPKHLASAASAAPAGGGAPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMX2</accession>
    <name>A0A074ZMX2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169157.1">
        <property type="nucleotide sequence ID" value="XM_009170893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMX2"/>
    <dbReference type="GeneID" id="20319981"/>
    <dbReference type="KEGG" id="ovi:T265_05799"/>
    <dbReference type="CTD" id="20319981"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="17045" checksum="22CDDFEEF178867F" modified="2014-10-01" version="1">MSPRMVTKRWQANCQARRTDQQPPDQQPIDCRLPDRQLTTFGLVRYVALLYVDPGRATELSNWSIRIKSYLTFTNDAGNKDSWLLRCGGHAESDSEPSVILADHVYSASTLSEINDKTFEHDEFTGPEDLMQFFTFNNVIFFNVKYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP30</accession>
    <name>A0A074ZP30_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167087.1">
        <property type="nucleotide sequence ID" value="XM_009168823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP30"/>
    <dbReference type="STRING" id="6198.A0A074ZP30"/>
    <dbReference type="GeneID" id="20318339"/>
    <dbReference type="KEGG" id="ovi:T265_04153"/>
    <dbReference type="CTD" id="20318339"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="29020" checksum="E374C8B86A234354" modified="2014-10-01" version="1">MSGNIIMHFEHVNALIVINVFMYCGQQLASGLPTIKTSSGSERANSPFEKRNNYFNKSYNLPSLKTSNILISDKLQTTGNPAAINGPNSIKEKPTRSSVRYKQKDQRNSEETSPRFVKFDTGETIRLRCRILRGPYLMWNKLGLDYPLTIGTRRFSPDERIRIQYKAPDKWVLTIAEAKLTDSGVYTCTTSTSSAPSDQFQHLCSVASKDGMVAKAEYANTSCQEENSGSVHDNQSNKKGSNEYYVTVGKQMWIFAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPC1</accession>
    <name>A0A074ZPC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167240.1">
        <property type="nucleotide sequence ID" value="XM_009168976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPC1"/>
    <dbReference type="GeneID" id="20318459"/>
    <dbReference type="KEGG" id="ovi:T265_04277"/>
    <dbReference type="CTD" id="20318459"/>
    <dbReference type="OrthoDB" id="10309620at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="390" mass="43597" checksum="910045ABAB62F672" modified="2014-10-01" version="1">MQKPKCWGLSTCRFENKHARTGYVLNQRKVKLKNKLRDEDNFDCERQLNSWRATCPTCQKTFKQSIPLPENDFVSVNQTNPRSLNHNLQPPSGCNLILKHEHSTASVHHSLTDSGIFVSADSSFTEQRMKHETDSPNFSHIPLSTEPPPSPAPPPGLVVPHMYSTTRPTYLTAPWTPILANINQPYNDLGSYEPTVPPAMFPIFNIFQSVETPSSVASLSSSSTASLNTQPAAEDESSRSSSTPYPNDTVFSQSNVETIESERKVDKVCSTSQQHIRLLEQSFCAQTGRNIPTLTVAKCVQNLRQNLIILAEAKKVINRQMELLRESYMEMTKGQLSSKSLHSIAASSSISEPKFGRWYSLQTLQGSLPGVQHETEFDILQNLFDLTLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPH0</accession>
    <name>A0A074ZPH0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171063.1">
        <property type="nucleotide sequence ID" value="XM_009172799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPH0"/>
    <dbReference type="STRING" id="6198.A0A074ZPH0"/>
    <dbReference type="GeneID" id="20321491"/>
    <dbReference type="KEGG" id="ovi:T265_07312"/>
    <dbReference type="CTD" id="20321491"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19512">
        <property type="entry name" value="RecA-like_ATAD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000470">
        <property type="entry name" value="ATPase family, AAA domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="341"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="586" mass="66237" checksum="2AD01694936080E0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQW6</accession>
    <name>A0A074ZQW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166753.1">
        <property type="nucleotide sequence ID" value="XM_009168489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQW6"/>
    <dbReference type="GeneID" id="20318084"/>
    <dbReference type="KEGG" id="ovi:T265_03897"/>
    <dbReference type="CTD" id="20318084"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10643" checksum="D825C3C2DD4DDBE4" modified="2014-10-01" version="1">MPPEGKHDGWDTANLPKPRQGKSRGRSPVRTTDLPVSKLVLQPLSVIGRYPKSLYECSTLMDNTSSHSNTILLLTTTRLIMNVVKSLPPKRVTSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQZ8</accession>
    <name>A0A074ZQZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168031.1">
        <property type="nucleotide sequence ID" value="XM_009169767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQZ8"/>
    <dbReference type="GeneID" id="20319089"/>
    <dbReference type="KEGG" id="ovi:T265_04907"/>
    <dbReference type="CTD" id="20319089"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17658" checksum="1B4B38161F1E63C5" modified="2014-10-01" version="1">METKVQDSGAIGRWNASDKIDAHGLAQYSRQSDPGKIVNIPYDQLFTQRIKTVIYNNNRYYSVDRGEKYEMRSFVFLERPAVRDSLRSLLEYKVIDFLLTDIHRINREKTGGGGIPWCKFRAASTEFDAMTKRFAIKFKFGAFIQDSQQQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR20</accession>
    <name>A0A074ZR20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166707.1">
        <property type="nucleotide sequence ID" value="XM_009168443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR20"/>
    <dbReference type="GeneID" id="20318049"/>
    <dbReference type="KEGG" id="ovi:T265_03862"/>
    <dbReference type="CTD" id="20318049"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14975" checksum="668A3464390AE01F" modified="2014-10-01" version="1">MLHNFQYLFLDCCIQQHRSYRFLLRTLPSSGNSPLSFLGFRRSFASLIPKQKPYDPLRAAVISRTGKSGNEMLRGLFTTVELGDRSPSQMLRHMRSLLCGRKLAVEIMAQLWPARQTSTLHVPRHQRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSR0</accession>
    <name>A0A074ZSR0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_13998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169847.1">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Mitogen-activated protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="MAPK"/>
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        <property type="entry name" value="MAPK_ERK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01770">
        <property type="entry name" value="ERK1ERK2MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="23706" checksum="A8DEAEF942AAE296" modified="2014-10-01" version="1" fragment="single">QICDFGLARIADPNCDQSGILTEYVATRWYRAPEIMLTSKIYTKAIDLWSIGCILAEMLSNRVLFPGKHYIDQLNLILEVLGSPCKGDLESISNYKARAYLEQLPFKPKVPWSQLYPYASPKALDLLDKLLCFVPSRRIKVEDALAHPYLEQYYDPTDEPVAQYPFTHESDNLPKEKLKLLIWDEIQQFKVNPDRKTAPSNSAPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSW3</accession>
    <name>A0A074ZSW3_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Adenylate kinase 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166046.1">
        <property type="nucleotide sequence ID" value="XM_009167782.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSW3"/>
    <dbReference type="GeneID" id="20317508"/>
    <dbReference type="KEGG" id="ovi:T265_03321"/>
    <dbReference type="CTD" id="20317508"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="368"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1956" mass="222753" checksum="4F48EF8893304138" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTB9</accession>
    <name>A0A074ZTB9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167123.1">
        <property type="nucleotide sequence ID" value="XM_009168859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTB9"/>
    <dbReference type="STRING" id="6198.A0A074ZTB9"/>
    <dbReference type="GeneID" id="20318363"/>
    <dbReference type="KEGG" id="ovi:T265_04177"/>
    <dbReference type="CTD" id="20318363"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70447" checksum="CC1366FD8C4469E0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVK0</accession>
    <name>A0A074ZVK0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166286.1">
        <property type="nucleotide sequence ID" value="XM_009168022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVK0"/>
    <dbReference type="GeneID" id="20317697"/>
    <dbReference type="KEGG" id="ovi:T265_03510"/>
    <dbReference type="CTD" id="20317697"/>
    <dbReference type="OrthoDB" id="10348322at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="36666" checksum="F995F3A8E11E6717" modified="2014-10-01" version="1">MRPNEQKGYGGWMNSLKVEIFGRYKINGSPLLYTPAYAQRHSKEFASLKLSVCEGVKYVYILGGDVTQEDIKNCNIFVSRGKVLDSSSSGWPVELTLQMVMDRYFLDLYNGSRTELVNYLSAIYTQLQPIVGGNEAFTDGPGFSMCFLEATPSDSLTYTDDKKSDRTISQSGQTSQTDLYRVDEITQDLSLHSQNNQEFETASSAVSKDESKEYITSCILSVTTENDAAEVKSREPLAELCLELVFRVPTQKMIPDGQQNVVKHLASVYLELRPEVEDTEAFSKEVQFFGKLRSAKRDFHYVPNIAFYGEKTKKSTEVGLKTKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVN8</accession>
    <name>A0A074ZVN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597285">
        <property type="protein sequence ID" value="KER19224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177033.1">
        <property type="nucleotide sequence ID" value="XM_009178769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVN8"/>
    <dbReference type="GeneID" id="20329778"/>
    <dbReference type="KEGG" id="ovi:T265_15613"/>
    <dbReference type="CTD" id="20329778"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13222" checksum="C92905F4A57C576E" modified="2014-10-01" version="1" fragment="single">MSVARTTPSELTGRPAKKLKKLVEFSPSDFSADYLKIRLPANLQCYQIACEVLWAENPNGTPTMQLNEAFSIGSEDCKQLVKTYPNIACVSQLLHCSEDCKQLVKTYPNIACVSQLPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWK8</accession>
    <name>A0A074ZWK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168519.1">
        <property type="nucleotide sequence ID" value="XM_009170255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWK8"/>
    <dbReference type="GeneID" id="20319462"/>
    <dbReference type="KEGG" id="ovi:T265_05280"/>
    <dbReference type="CTD" id="20319462"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12842" checksum="56007B14F1BB122F" modified="2014-10-01" version="1">MFQEDLNQRTETLPKEQNSQCRSMNPSTEYGRYVWKIFEDPPCLTVDANVASRALVYALDSIDPQLPILLPWKLTIEGLQHAAIDFLIRLLMLLAMRFSSDQPIGCISWSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWL1</accession>
    <name>A0A074ZWL1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164341.1">
        <property type="nucleotide sequence ID" value="XM_009166077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWL1"/>
    <dbReference type="GeneID" id="20316127"/>
    <dbReference type="KEGG" id="ovi:T265_01939"/>
    <dbReference type="CTD" id="20316127"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="13143" checksum="DAB391D6CDECA01A" modified="2014-10-01" version="1">MKALTEWVGIWPVSCRLIQAISDPDFSRTIGLSRNRLHNLQHNAAKLGRVKHSGVRWSQQESRSFLSLANNLYPSCDTQTMVFTRLERYFPNRSAISIKTRLRVLNWQAQQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX74</accession>
    <name>A0A074ZX74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165721.1">
        <property type="nucleotide sequence ID" value="XM_009167457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX74"/>
    <dbReference type="STRING" id="6198.A0A074ZX74"/>
    <dbReference type="GeneID" id="20327318"/>
    <dbReference type="KEGG" id="ovi:T265_13150"/>
    <dbReference type="CTD" id="20327318"/>
    <dbReference type="OrthoDB" id="6264444at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031937">
        <property type="entry name" value="PNISR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15996">
        <property type="entry name" value="PNISR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="887" mass="98395" checksum="F3178394D7192B95" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXC5</accession>
    <name>A0A074ZXC5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_11478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dynein-attachment factor required for cilia motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DNAAF19/PR46b family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597128">
        <property type="protein sequence ID" value="KER19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176409.1">
        <property type="nucleotide sequence ID" value="XM_009178145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXC5"/>
    <dbReference type="STRING" id="6198.A0A074ZXC5"/>
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    <dbReference type="KEGG" id="ovi:T265_11478"/>
    <dbReference type="CTD" id="20325646"/>
    <dbReference type="OrthoDB" id="447931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042422">
        <property type="entry name" value="CC103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="13">
        <location>
            <begin position="280"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="12">
        <location>
            <begin position="373"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57596" checksum="D8870E5572078417" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXM3</accession>
    <name>A0A074ZXM3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_11391"/>
    <dbReference type="CTD" id="20325559"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13450" checksum="9D302183922CBAC9" modified="2014-10-01" version="1">MLNDIDVPPAVCDDKRPMSSTAQLPQQQSTPSRLLRILPFDPRVFGERSDSPTYRFLPSPLLGRFGRNLFTSPIVIALQQLDTNLEFRSLSTSAIQTPNLLYLAQVPQISKLPVINGGTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXR3</accession>
    <name>A0A074ZXR3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXR3"/>
    <dbReference type="GeneID" id="20315839"/>
    <dbReference type="KEGG" id="ovi:T265_01651"/>
    <dbReference type="CTD" id="20315839"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9024" checksum="593138A955996247" modified="2014-10-01" version="1">MYEKRLKWLKLFSSMKHPSAMWRVVPITTSSGSLELNLVDKGKTSLDEARNLQEKLLSFKAGARVAATDLVQDTPLFAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY42</accession>
    <name>A0A074ZY42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597092">
        <property type="protein sequence ID" value="KER20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176148.1">
        <property type="nucleotide sequence ID" value="XM_009177884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY42"/>
    <dbReference type="STRING" id="6198.A0A074ZY42"/>
    <dbReference type="GeneID" id="20329557"/>
    <dbReference type="KEGG" id="ovi:T265_15392"/>
    <dbReference type="CTD" id="20329557"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="92020" checksum="E612931EC56D4D2C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYD4</accession>
    <name>A0A074ZYD4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165284.1">
        <property type="nucleotide sequence ID" value="XM_009167020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYD4"/>
    <dbReference type="STRING" id="6198.A0A074ZYD4"/>
    <dbReference type="GeneID" id="20327236"/>
    <dbReference type="KEGG" id="ovi:T265_13068"/>
    <dbReference type="CTD" id="20327236"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="335"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="552"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="650"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="103740" checksum="65F364BE100E140D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYQ9</accession>
    <name>A0A074ZYQ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597068">
        <property type="protein sequence ID" value="KER20319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175930.1">
        <property type="nucleotide sequence ID" value="XM_009177666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYQ9"/>
    <dbReference type="GeneID" id="20329509"/>
    <dbReference type="KEGG" id="ovi:T265_15344"/>
    <dbReference type="CTD" id="20329509"/>
    <dbReference type="OrthoDB" id="6252645at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="448" mass="50134" checksum="B1350900959A56BF" modified="2014-10-01" version="1" fragment="single">NEFQVIECCFRASRCLCCTSLLPVTPTDTRRQWLPAVVLQSMTGSSLLPASSTPSDETTVQFPTFSIVDPPKLLPIPAVASPSSTCHSPFRWALAVPLEATYTYLREEEQCVFHLSVEPRCGIANSIPISWVMPQSTLVISSKRKPNPVSLIAYTTTDILHQSISEFHMHMDINVLQNGVVQCRFTLMQPVCVSFCDLLQRASSLSRLTVAPIWSSIEPETIYSRHCRWRLRAAAFHPTGFLESPALSTLRTFFQTKLLHLPFEILLDKTGQWHWITAGPFEGLALCITYPEEDKSGSLILQAFSSSQSLLDLFRRALDEFPADQIRFEALDGTALAANHDNQPNGPTNSELSLLTDCLLAEIQFLTNQLETVIRASMRERVPPVSTILEAGGIGGSLDLAYRLTEWRDLVTQSHMLPVSRLDPSPHYSDLCRRTDRTLKQLCCQRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYR6</accession>
    <name>A0A074ZYR6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167793.1">
        <property type="nucleotide sequence ID" value="XM_009169529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYR6"/>
    <dbReference type="GeneID" id="20327737"/>
    <dbReference type="KEGG" id="ovi:T265_13570"/>
    <dbReference type="CTD" id="20327737"/>
    <dbReference type="OrthoDB" id="6313978at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="11804" checksum="4A3ED5830A64E082" modified="2014-10-01" version="1" fragment="single">PLDVDQTDNAPSTCSASQPCIRPRQRESALIKVRQRPRNMQHVTASYQSQAVCVSIGLSSGSDPPISSLGPLYIPTRTHLFGIWLLRSLLQLDVLHQAASCFGRYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYX3</accession>
    <name>A0A074ZYX3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165139.1">
        <property type="nucleotide sequence ID" value="XM_009166875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYX3"/>
    <dbReference type="STRING" id="6198.A0A074ZYX3"/>
    <dbReference type="GeneID" id="20316784"/>
    <dbReference type="KEGG" id="ovi:T265_02596"/>
    <dbReference type="CTD" id="20316784"/>
    <dbReference type="OrthoDB" id="2286360at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1253" mass="138443" checksum="645390A307DF9276" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ81</accession>
    <name>A0A074ZZ81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597051">
        <property type="protein sequence ID" value="KER20489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175767.1">
        <property type="nucleotide sequence ID" value="XM_009177503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ81"/>
    <dbReference type="GeneID" id="20325142"/>
    <dbReference type="KEGG" id="ovi:T265_10974"/>
    <dbReference type="CTD" id="20325142"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8537" checksum="CB452275E10694B3" modified="2014-10-01" version="1">MLSGRILVTEKKEIDLRLRFHTVSKEEAEGPSITTDDPVRAVRLDYDILRSVTLDTSYLLSRALVEFLEVRVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZL3</accession>
    <name>A0A074ZZL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167554.1">
        <property type="nucleotide sequence ID" value="XM_009169290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZL3"/>
    <dbReference type="STRING" id="6198.A0A074ZZL3"/>
    <dbReference type="GeneID" id="20327690"/>
    <dbReference type="KEGG" id="ovi:T265_13523"/>
    <dbReference type="CTD" id="20327690"/>
    <dbReference type="OrthoDB" id="68108at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF4">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="735"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="836"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="897" mass="99298" checksum="9AAD05A1493D597C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F6</accession>
    <name>A0A075A1F6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596984">
        <property type="protein sequence ID" value="KER21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175049.1">
        <property type="nucleotide sequence ID" value="XM_009176785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F6"/>
    <dbReference type="STRING" id="6198.A0A075A1F6"/>
    <dbReference type="GeneID" id="20329312"/>
    <dbReference type="KEGG" id="ovi:T265_15147"/>
    <dbReference type="CTD" id="20329312"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="448" mass="50254" checksum="EF87A2F48F36090C" modified="2014-10-01" version="1" fragment="single">RDLNVEVECRKSSDPGSLTHQLKPCRTYQFSNISLLVLHRKESTPCSSTDDIRPRSPSPRNTSVFTKPTPTKPKSDSHPTRTHSKPSGDPMPDVDKPLDRSSVSLRSLLNWAPVNKPPPTYRQNRTTASNNSAPSSEVVKKSDPSPVKHSPIIPNLASNSAPQSDLLAPQLRLDADGNIVLDETSLLVSLPETTMNTSGMRFVDEESGLLSVTYNSFRPQEKRGGRWDARETVRFYRALSTIGPDFYLMLKLFPNRNREELKRKFKRESRAHPYLVNQALRNRRSYDLTALVALSDEDEDDEKEEKKDVKEKIEKKPIVRSRRKRSPATKIQKTSRGSNNYDPNKVLETIDAVLAKETADDNVSGVLAVEAPSSGQTTCVLDRMIAAKQREVELETVGSTKIKQPSSRPTTRAHPQRTAIRRREAELMEYELVPALVTFPAAPLPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M5</accession>
    <name>A0A075A1M5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164111.1">
        <property type="nucleotide sequence ID" value="XM_009165847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M5"/>
    <dbReference type="STRING" id="6198.A0A075A1M5"/>
    <dbReference type="GeneID" id="20315945"/>
    <dbReference type="KEGG" id="ovi:T265_01757"/>
    <dbReference type="CTD" id="20315945"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="210"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="407" mass="45562" checksum="4C5FB6339754B77A" modified="2014-10-01" version="1">MIKMYYLDKLVSGAKEYYRSVNRANMSGAIDIVVIQQPDGTFKSTPFHVRFGKSGVLVPRSNLVEIRINDKLIDNLTMRIGSNGECFFDEAFDNQQHHSPIKSPRNIGTEDLFDKQMNIEDANSKTQTFDFGPSSPSDNLTESLSIQSPINTTCSDYEWNSSTSEDQESFDSLSRSSVDDGTVEDLPSPTQLPSWASFPNLSEDVPDSYDVKSDVRGQLMPLMGLEWVHNDVVSLYHKIAANGYRFLYLSSRSVGQARSTRGMLCSLEQNGHRLPDGPILLAPFSLWRAIHKEVIQRKADEFKIACLQQVRNLFPQEAYNSTSGQFPPLVAGFGNRATDIKTYRAVGLQGSHIFTVNRLGEVVCGNDESVLATGKSRASQTSPLTYRSLTSMVNDYFPQRKVAYFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M6</accession>
    <name>A0A075A1M6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163089.1">
        <property type="nucleotide sequence ID" value="XM_009164825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M6"/>
    <dbReference type="STRING" id="6198.A0A075A1M6"/>
    <dbReference type="GeneID" id="20315118"/>
    <dbReference type="KEGG" id="ovi:T265_00930"/>
    <dbReference type="CTD" id="20315118"/>
    <dbReference type="OrthoDB" id="6283885at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704480" evidence="2">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="609" mass="66740" checksum="B4567301D37C5D5F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1T0</accession>
    <name>A0A075A1T0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163948.1">
        <property type="nucleotide sequence ID" value="XM_009165684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1T0"/>
    <dbReference type="STRING" id="6198.A0A075A1T0"/>
    <dbReference type="GeneID" id="20315806"/>
    <dbReference type="KEGG" id="ovi:T265_01618"/>
    <dbReference type="CTD" id="20315806"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="30870" checksum="C96214F7B8B9EFC1" modified="2014-10-01" version="1">MKLQLSASTNTKVIELCGRQSPEKLTITRSNIPSERLELEISEDIHLEENVLTVLVDRLLSSPIPKVTSTADSFTVGIPTAATEATIAVWSGFSKLQIYRPFTHHVTLPREKCATYGVQLQIKSLRYGTPSSLLEVVPDDTGRPGRPQLLTSMPVGDHLIKVKWNEPMNRMSCPHKYVVKQTSSRGIEAAVVHIPATEPLVLTLQNRGRHISSLSTLLTVENGVRKQFTIIGFSSTCDEVVQIWKVIQESKTVYLTLLPCALCDAAKENNLPVSFGLGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1X9</accession>
    <name>A0A075A1X9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164004.1">
        <property type="nucleotide sequence ID" value="XM_009165740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1X9"/>
    <dbReference type="GeneID" id="20315862"/>
    <dbReference type="KEGG" id="ovi:T265_01674"/>
    <dbReference type="CTD" id="20315862"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12315" checksum="FE6834CC13A9AB98" modified="2014-10-01" version="1">MILGDKGFIKKVRFLEVTSERPEPTAPPKSQQESRQASRPVNHSINSAKLMSPHARHRSTIECDQRSKFKAQCQSLTSVRSLNHTTKPNRRTRLTSAQFSSELTELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3T8</accession>
    <name>A0A075A3T8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163247.1">
        <property type="nucleotide sequence ID" value="XM_009164983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3T8"/>
    <dbReference type="GeneID" id="20315228"/>
    <dbReference type="KEGG" id="ovi:T265_01040"/>
    <dbReference type="CTD" id="20315228"/>
    <dbReference type="OrthoDB" id="6272054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18598" checksum="B74B2A491787C960" modified="2014-10-01" version="1">MFYLKPISQKNLHHKREIQLGSRAKPVAGCRRIFNNLMSSTLQLYTCIAIFQISWRLKHERPSWVQHGNRPHANREFSWNTLGGLDQPESFLNPLTCEETKLGTETQLASSLRLKHEAAWGSTFSCLRTSQTRDSAGFQVSLSKNQLSLQMSVYSRLLLLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A416</accession>
    <name>A0A075A416_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165957.1">
        <property type="nucleotide sequence ID" value="XM_009167693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A416"/>
    <dbReference type="STRING" id="6198.A0A075A416"/>
    <dbReference type="GeneID" id="20317447"/>
    <dbReference type="KEGG" id="ovi:T265_03260"/>
    <dbReference type="CTD" id="20317447"/>
    <dbReference type="OrthoDB" id="1925699at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="17968" checksum="0D4995384735C3D7" modified="2014-10-01" version="1">MGVFSEKGDGLMARIGHGVQVGLSWVHERDGRVPSNAIDAGCGVYIGRMNQNGDLLPGKVVPRLNQAYCAFGGREHSHHSYEVLCDTAAHRTNKCWENANNGHVPKNAIVAGLASDGSPLYVARAHINGERVVGKIHGGHHCGYFPYGGEEHSLHSYEVLVWREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A470</accession>
    <name>A0A075A470_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596915">
        <property type="protein sequence ID" value="KER22164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174085.1">
        <property type="nucleotide sequence ID" value="XM_009175821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A470"/>
    <dbReference type="STRING" id="6198.A0A075A470"/>
    <dbReference type="GeneID" id="20329095"/>
    <dbReference type="KEGG" id="ovi:T265_14929"/>
    <dbReference type="CTD" id="20329095"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13444" checksum="4943F71528D8260E" modified="2014-10-01" version="1" fragment="single">MKEITKRLGAVGATRLPGWGPRDPHCAWSGTLQVPSLSTFILSFIIRLSNKSWLYGSEAPVLNTDVMLSMMMTLRKEAIRPYYCSVGTGKAYGRDIPEAHYRACMYAGVKIAGTNAEVMPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A626</accession>
    <name>A0A075A626_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596874">
        <property type="protein sequence ID" value="KER22894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173352.1">
        <property type="nucleotide sequence ID" value="XM_009175088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A626"/>
    <dbReference type="GeneID" id="20323279"/>
    <dbReference type="KEGG" id="ovi:T265_09100"/>
    <dbReference type="CTD" id="20323279"/>
    <dbReference type="OrthoDB" id="6272382at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="32938" checksum="DA988F8B1A9C0C45" modified="2014-10-01" version="1">MHSSPLNPALHRSLTVLDLCTNIPARACSAQLPTPQIIGERNCGSYNQYTTSTWFLQLTMMMMMMIDAFANNFSPVNNYYLRMVIIRRDTPILSETVNGFMSHRFKSKYDRHESHHSSSRHRRHRHRSHSRSPSRGQEIEIQMKPLVLASENETTRQNEIDYIEGSSFTQKSFSSSRSHPKPFAPDSSGPVASATKSQYSSMLAERAHEAAIFGQLTIPPSSTVLGSDPSESKERLVSSVDTVKQLIHPQFDKPDETAWNNWLIRLRELKEARAKAAADAKKIRPTNGVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9E7</accession>
    <name>A0A075A9E7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163907.1">
        <property type="nucleotide sequence ID" value="XM_009165643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9E7"/>
    <dbReference type="STRING" id="6198.A0A075A9E7"/>
    <dbReference type="GeneID" id="20315772"/>
    <dbReference type="KEGG" id="ovi:T265_01584"/>
    <dbReference type="CTD" id="20315772"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="163" mass="17984" checksum="A410D049D4C16B1F" modified="2014-10-01" version="1">MTTSGAAVSRLAFYDALVNNSLVELKRCVKLRKIDLNVRLSNVRKRNRTDLCPVHLVIYKGYLAMLHYLIQNGINVHQATLTLQSRAVHFAALRHQVPCLQMLLNTDAQMNALDTVGNTPLHYAAEDGDRALLSLLLNNGTSVDSQDITNKTSLMRAAGSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA51</accession>
    <name>A0A075AA51_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596809">
        <property type="protein sequence ID" value="KER24444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171788.1">
        <property type="nucleotide sequence ID" value="XM_009173524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA51"/>
    <dbReference type="GeneID" id="20322053"/>
    <dbReference type="KEGG" id="ovi:T265_07874"/>
    <dbReference type="CTD" id="20322053"/>
    <dbReference type="OrthoDB" id="10439169at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13725" checksum="BD966ABA2ACD6C12" modified="2014-10-01" version="1">MCGVHKEMLRTPVDKKLLLFEKYTHLKINLVFARDSAEPLDYDIRQLNVLHTGRLMFQLTRYSKSHNRRSPRVSVNPMSHLNPNRTKLANYTHLQTNLVLRDSTATQLNLSFVTFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAK1</accession>
    <name>A0A075AAK1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter, ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCE family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163333.1">
        <property type="nucleotide sequence ID" value="XM_009165069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAK1"/>
    <dbReference type="STRING" id="6198.A0A075AAK1"/>
    <dbReference type="GeneID" id="20315296"/>
    <dbReference type="KEGG" id="ovi:T265_01108"/>
    <dbReference type="CTD" id="20315296"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03237">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="70"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="356"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69328" checksum="6B7FD9FF865EA480" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB09</accession>
    <name>A0A075AB09_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163296.1">
        <property type="nucleotide sequence ID" value="XM_009165032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB09"/>
    <dbReference type="GeneID" id="20315277"/>
    <dbReference type="KEGG" id="ovi:T265_01089"/>
    <dbReference type="CTD" id="20315277"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11733" checksum="D6758BDAADAC5190" modified="2014-10-01" version="1">MLKRVYEAFLYVDLSSKNDRKQLEKEGTQRCKDVPMPPSAQLKRPPTPLISIGLHFFTFLRSSAVITILKGHKPEEQGHASPEESTRHLIMYGENRGQKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB66</accession>
    <name>A0A075AB66_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171408.1">
        <property type="nucleotide sequence ID" value="XM_009173144.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AB66"/>
    <dbReference type="GeneID" id="20321766"/>
    <dbReference type="KEGG" id="ovi:T265_07587"/>
    <dbReference type="CTD" id="20321766"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="9">
        <location>
            <begin position="726"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1413"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1810"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1437"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1816"/>
            <end position="1827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208709" checksum="DBF8E4290C601E36" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEW0</accession>
    <name>A0A075AEW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169161.1">
        <property type="nucleotide sequence ID" value="XM_009170897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEW0"/>
    <dbReference type="GeneID" id="20319985"/>
    <dbReference type="KEGG" id="ovi:T265_05803"/>
    <dbReference type="CTD" id="20319985"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8039" checksum="E8A24B75D6BCB73C" modified="2014-10-01" version="1">MVKSERKVRHLNESVLEASSAGWGSPTIFPPSVIQVRAIKILGRENMGLRQLRNEGSGFDGRPPVDACYGRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGK9</accession>
    <name>A0A075AGK9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596691">
        <property type="protein sequence ID" value="KER28824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167440.1">
        <property type="nucleotide sequence ID" value="XM_009169176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGK9"/>
    <dbReference type="STRING" id="6198.A0A075AGK9"/>
    <dbReference type="GeneID" id="20318613"/>
    <dbReference type="KEGG" id="ovi:T265_04431"/>
    <dbReference type="CTD" id="20318613"/>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="256"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="597"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="872"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="956"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137116" checksum="940C8A325778C3BD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGW1</accession>
    <name>A0A075AGW1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIGR01777 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167169.1">
        <property type="nucleotide sequence ID" value="XM_009168905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGW1"/>
    <dbReference type="STRING" id="6198.A0A075AGW1"/>
    <dbReference type="GeneID" id="20327617"/>
    <dbReference type="KEGG" id="ovi:T265_13450"/>
    <dbReference type="CTD" id="20327617"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092:SF0">
        <property type="entry name" value="EPIMERASE FAMILY PROTEIN SDR39U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11092">
        <property type="entry name" value="SUGAR NUCLEOTIDE EPIMERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="2">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39503" checksum="679FB9820E2F30FB" modified="2014-10-01" version="1" fragment="single">GGTGLIGKAISAQLLSAGHTVKVVTRTPKSNNHVTWDSIKSSGLPPSTQVVINTTGRSIGEVNPLFCLPGRYKQYIEEVFSSRIDTTKILVKAAQSFPLKAFINASAVGFYKPSLTETFTEAAAYEDHGMITRLVKEWELAAQMPERKDIKQYQLRLGFYKPSLTETFTEAAAYEDHGMITRLVKEWELAAQMPERKDIKQYQLRLGVVLAENSNFVKSLYPSHRVGLGGPIASGRQWISWIHLDDVVRIVQYLLDPESSVPVGPVNATAPFACRQDAVSKAFSEAVNAPNLPFGPIRTPAFVAKLILGSDRSTLLLEGQRVVPQKLLDAGFNFKYPRLEDALEAIFQRRPTSIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH85</accession>
    <name>A0A075AH85_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166790.1">
        <property type="nucleotide sequence ID" value="XM_009168526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH85"/>
    <dbReference type="STRING" id="6198.A0A075AH85"/>
    <dbReference type="GeneID" id="20318112"/>
    <dbReference type="KEGG" id="ovi:T265_03925"/>
    <dbReference type="CTD" id="20318112"/>
    <dbReference type="OrthoDB" id="6239296at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="377" mass="42371" checksum="BD80E06EFCD408C7" modified="2014-10-01" version="1">MIVGSQPLVPSLSALILFSTIRFPNKSWFYGSGASVLNTDSMLSMMLMIVYGIEQQAFTLSVAGWQLIRPIDVISRYLDLLDFIISFYYASGVGFVVLSSLLVLLIILIRMLPMKRGGAVLQSVFVLLGGTFGVVFMLLDYIRSSVWQILASNAEITFCYVAIVGCLSFVFFYWFHLPETLVFKYPRTKVIMKYVLRIVGALVITSAIYLPFTEHELLTGLAYYASSYVSNEVASESPVTRILGYTSPKLARVIIVMAVVLFVELVEWVQQIVWKPSPRKKRAINGYPEVVRSSPGSPWASSSPFQYHSPYVTAKPQTPRSAGFPSDSRRTSLYKGPGFVRNTEYSNSPFRPSRSSYGERSYRKIPKEEILTDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH89</accession>
    <name>A0A075AH89_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166800.1">
        <property type="nucleotide sequence ID" value="XM_009168536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH89"/>
    <dbReference type="STRING" id="6198.A0A075AH89"/>
    <dbReference type="GeneID" id="20318122"/>
    <dbReference type="KEGG" id="ovi:T265_03935"/>
    <dbReference type="CTD" id="20318122"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000515">
        <property type="entry name" value="early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF155">
        <property type="entry name" value="EARLY GROWTH RESPONSE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="440" mass="49654" checksum="78782BD1954E00B7" modified="2014-10-01" version="1">MNRKITFLTASRYGGRSQEMTRITPKFSLGFIDLKNIFNDIPTGYTPTNAPDESFRDFSKLENLDTPTPLENPDTETVFVYSVNTGAAESHGSMATEARQPLHYCKPEPCSEMGYTTTFGTTDGLLLTPQQQQQQQQQQQQPISFCYPADYQNMEQKPCMVHHQSRHIQITSSTQYSPSCPTYTTPPTQNDLRSDSTSVCTLQTCASLPPPYASSPLSNSSAPALYTNTTELICNADPPSYLVQQPSCRESTPFDQLRVISSTPPSDRNPTEASTFAGKANASIHNCMLFDVCELSQLKKEDNTGTKSLKCAKVLEKAFLCEFPNCIKRFARVDELKRHQRTHSDVKQFVCDICQKGFTRSDHLMTHRRTHTGERPYPCWYCDRRFARSDERNRHAKVHSREKTGRSRKPRVSKVKTVTTGLIPSAEVPTVWLNNLSLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHA5</accession>
    <name>A0A075AHA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166720.1">
        <property type="nucleotide sequence ID" value="XM_009168456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHA5"/>
    <dbReference type="STRING" id="6198.A0A075AHA5"/>
    <dbReference type="GeneID" id="20327512"/>
    <dbReference type="KEGG" id="ovi:T265_13345"/>
    <dbReference type="CTD" id="20327512"/>
    <dbReference type="OrthoDB" id="10028342at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545:SF13">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 93F, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21545">
        <property type="entry name" value="TRANSCRIPTION FACTOR MLR1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="496" mass="56105" checksum="8D3792682EBE67C2" modified="2014-10-01" version="1" fragment="single">HKKLEYSSAPAIEATQLQPLSIKHTEHSLKTKPYVSHSINEMLNGKSQADRRIQSVECMPLCDTIHIPKRSVDHWSSEATPSVGTRALKAVHEEKTSYSGRCEHNPGTKSDGEKQFQCRTWSAPLSTLCQSNNRQLEMLSREAYTNACTSEAEDQPLDLSLKRSFTQLDRGMLRSLGMCIFRKFPLRSLAQIINYPVIRNGICPTDPFALEQTKATVSRDRPYSTPFDFIFRQKYHQTLHTLLTASEAATNYPTLPDLPVRTSISDSSRSFVQFFREQWLKKNVASLVHQKMGRRPGMYRDRPPPDSEPTTSKINSTADAATITSATRFTKIKCKYGMSITRDHPPGKPLRRPYTEAELSAAVRAICFGRLGTRRAASVYGIPRSTLRNKICKLNELKRREEERQGGQTILMPDFLQGLLQQMREKSAAGRTATSSMVARGAFTIDERQDSVDYPFSTDDFVQLNRRGPEVQKPTLRISVTPNRAASIFQVSDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIB6</accession>
    <name>A0A075AIB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164938.1">
        <property type="nucleotide sequence ID" value="XM_009166674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIB6"/>
    <dbReference type="STRING" id="6198.A0A075AIB6"/>
    <dbReference type="GeneID" id="20327168"/>
    <dbReference type="KEGG" id="ovi:T265_13000"/>
    <dbReference type="CTD" id="20327168"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="286" mass="33135" checksum="74B397F1C4DDE02D" modified="2014-10-01" version="1" fragment="single">NTRRNQKFRFIKETTHKVAENSSTAHDRFRPSWGSPDERNSRGSINLMFYLKPIGLFSKNTLVCNSFWFSRETHLNLSFMMFYNCMGFSLETRGATIDKYTHLQINLVFTRDSTESLAYDILQLNVLHTGRLMFQLPRYSRYRSIYSQGSLYEEVQILQSQTPGSTPLTQTTAAHRPPHVSVGTIFEISQYIPMKETTHKIMSRDLVLPAVSSGWNRMLNLIGAIDDRNGTRLTKWVCDTIENLYIEKYTQLRISLVCTRDSSEFLVSRILQLNVLHTGHLMFQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIF5</accession>
    <name>A0A075AIF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164645.1">
        <property type="nucleotide sequence ID" value="XM_009166381.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AIF5"/>
    <dbReference type="GeneID" id="20316381"/>
    <dbReference type="KEGG" id="ovi:T265_02193"/>
    <dbReference type="CTD" id="20316381"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="690"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1282" mass="143400" checksum="E8A84E1254177FA0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ1</accession>
    <name>A0A075AIJ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164515.1">
        <property type="nucleotide sequence ID" value="XM_009166251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIJ1"/>
    <dbReference type="GeneID" id="20316280"/>
    <dbReference type="KEGG" id="ovi:T265_02092"/>
    <dbReference type="CTD" id="20316280"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="161"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="290" mass="33371" checksum="01CA376EDE65EE94" modified="2014-10-01" version="1">MFTVYAIVKFSIILVDMVSTQHHGLETLSPEKFRDLHNAFRKMILNGSVPNQPKAKAMPDLFRTFRNLMRDQEPKLTPVVTRLLASIVLRRLTVAREMLTREQQAGFRPGRGCVDQIFTLRQVLEQRHTYKRPTILVFLDFRGAFDSVDRSVLIETLAHQGMPQKFVNIIRSLYSQTSGRVLDNKLNENAKKWAEKCVYKHQAKINDGENLAVSSDSSENPVELWFDKHKTYNFGKLTNQTSTETDPYTQVFWEKNKALGVLSDFCETMKDGKGNPVGQAYFSVCRYSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ75</accession>
    <name>A0A075AJ75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163437.1">
        <property type="nucleotide sequence ID" value="XM_009165173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ75"/>
    <dbReference type="STRING" id="6198.A0A075AJ75"/>
    <dbReference type="GeneID" id="20326901"/>
    <dbReference type="KEGG" id="ovi:T265_12733"/>
    <dbReference type="CTD" id="20326901"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000006">
        <property type="entry name" value="High mobility group protein B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="284" mass="31885" checksum="3D334B8EAC83DF84" modified="2014-10-01" version="1" fragment="single">FLLPAPSRGLIAVAGLDLSALYTARPAVPTPSPYAAKQLTVAGLACSGLFVGLRDLDNMNRMKDKNRPKGAMSAYACFVQVIREEHKKKHPGEQIVFSDFSKKCAERWKLMTPKEKKRFEDLAALDKERFNREMSDYVPPEGMKKGKKRKVPRDPGLPRRAWSAFFFFCDEHRGKVKENNPEFKVADVAKELGRQWEACQDKAKYELLAQQDKQRYEEDMVKYRAGVYVPVQKKPAGATPNPTTLDLTENPGSDCNPTPGTGGDENGAELEDEDDGEPDEVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ78</accession>
    <name>A0A075AJ78_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163412.1">
        <property type="nucleotide sequence ID" value="XM_009165148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ78"/>
    <dbReference type="STRING" id="6198.A0A075AJ78"/>
    <dbReference type="GeneID" id="20315375"/>
    <dbReference type="KEGG" id="ovi:T265_01187"/>
    <dbReference type="CTD" id="20315375"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="12424" checksum="98010719B7A97673" modified="2014-10-01" version="1">MRYLAAYMLCQLGGKERPTAADIQNVLSSVGIEHESERISKLLSELEGKDITKLIAEGRMKMASVPMGGGGAPAVATTAAPATAAAGAPAAEAPKKEAPKEEKKEESESEDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJR9</accession>
    <name>A0A075AJR9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162320.1">
        <property type="nucleotide sequence ID" value="XM_009164056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJR9"/>
    <dbReference type="STRING" id="6198.A0A075AJR9"/>
    <dbReference type="GeneID" id="20314499"/>
    <dbReference type="KEGG" id="ovi:T265_00311"/>
    <dbReference type="CTD" id="20314499"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF25">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="411" mass="45287" checksum="BD83CF43DEE490E3" modified="2014-10-01" version="1">MKPVEGSITFSSGIDTINESDIDDEIFLGNEPSIVLERRRRSHTAAEQRRRNAIKKGYEELRELVYPKNSGSSSTNRISKTCILNKTVSEIEKHNKELEQKQTDIERLEKSVATLKILNSFYEERAKGTIPQNAPAEPVSDELKFHIFKLFSDSLFASFDSRVSLAPFSEFADCILRWLEDTCDRRFLSKLMDSVVSSTLLVTEDQSVIPRAMSGNFCPNPSDLSPNQGSTGFPANSPDNVPFKDSPHSGEWIQSDTVSNKAAIPIMPDTDYPVKPTPLSSATYEQHQPFTNNPDIVPNNSGFASTHDHAPTTTPTKFNGHKRNSLPHDLTVVFRAQASKPVESASSSSSKRDFDFPVPHSTLASASRGIRSSGTFAPKFPALVSTQPSGSTAMPSSFGLTTSAAQYKPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJX6</accession>
    <name>A0A075AJX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162115.1">
        <property type="nucleotide sequence ID" value="XM_009163851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJX6"/>
    <dbReference type="GeneID" id="20326603"/>
    <dbReference type="KEGG" id="ovi:T265_12435"/>
    <dbReference type="CTD" id="20326603"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16439" checksum="A3DA9C61FA3208D5" modified="2014-10-01" version="1" fragment="single">MSDSFDANASSCALQAGVDTHRTNNTEQLYLFIEGRLFLSSMKIQHRPSHRVIWRPPTASQSWTQLHPVAISYRWRVSCLQTNQVTQAQCELISIKKSLSCNNLPVPSYHATRRNHAAWDTARLPKPRQGKSRGKGQVRTTDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUN0</accession>
    <name>A0A074YUN0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600661">
        <property type="protein sequence ID" value="KER18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177762.1">
        <property type="nucleotide sequence ID" value="XM_009179498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUN0"/>
    <dbReference type="GeneID" id="20330186"/>
    <dbReference type="KEGG" id="ovi:T265_16021"/>
    <dbReference type="CTD" id="20330186"/>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15009" checksum="9902956114E84E2B" modified="2014-10-01" version="1" fragment="single">ETYCNCPDEAYGDQCELIRGKWAQWSPWSECSPSCGVSEYQRRVRTRDCLGEACRGGEGHLQMEMCPTMPCPDETLALARQGRWEDPGELKIQMLQAQAARCVKLVGAIAEALILISCVFSGLTATAMVFSVYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXN7</accession>
    <name>A0A074YXN7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597178">
        <property type="protein sequence ID" value="KER19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176694.1">
        <property type="nucleotide sequence ID" value="XM_009178430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXN7"/>
    <dbReference type="STRING" id="6198.A0A074YXN7"/>
    <dbReference type="GeneID" id="20325875"/>
    <dbReference type="KEGG" id="ovi:T265_11707"/>
    <dbReference type="CTD" id="20325875"/>
    <dbReference type="OrthoDB" id="10061407at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF31">
        <property type="entry name" value="EXTRACELLULAR NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="376" mass="43372" checksum="56FE6D2B077EA015" modified="2014-10-01" version="1">MGFIVHSKEKGFPEFGWIAVHLDPDSVEAELNALYETAENFRKENKLDDVLLAGDMNADCRYLSKRRMRELRLIKDTHYYWLINDECDTTVHSNNCALDRMIGYGTNLKSAVKGQRGNAYRYDNELNLDIDTILIRYDVVVILEIRDKKGTAFQKLLQDLNQQSNESYASYVSEALGRTTSKEQYGILYKPTKVTVTGISVFPDPQDKFERPPMSFIVNVEGGSLKFGWVAVHLDPDAVEAELNALYENAETFRKQHKLENVLLAGDMNADCRYLSDRKMKQLSLMKDTSYVWLISDGHDTTVHSNNCALDRMIVYGDELMSAIKDQQAQAYRYDDEMKLDHKTAKDISDHYPVEFELEEMNKPKEAASRRRRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXY9</accession>
    <name>A0A074YXY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 3 subunit G N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL614821">
        <property type="protein sequence ID" value="KER18047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178206.1">
        <property type="nucleotide sequence ID" value="XM_009179942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXY9"/>
    <dbReference type="STRING" id="6198.A0A074YXY9"/>
    <dbReference type="GeneID" id="20330498"/>
    <dbReference type="KEGG" id="ovi:T265_16333"/>
    <dbReference type="CTD" id="20330498"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 3 subunit G N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10405" checksum="9734A4FAABE30924" modified="2014-10-01" version="1" fragment="single">SIDDITEDNLPPVEVSTNPERGTKVVIQHYFNEDGDLIKETKEYRTEKRLVASQIAVRKKWAKYGAAKNDPPGGNSANTYPAETVTMQLVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYY7</accession>
    <name>A0A074YYY7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597122">
        <property type="protein sequence ID" value="KER19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176367.1">
        <property type="nucleotide sequence ID" value="XM_009178103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYY7"/>
    <dbReference type="GeneID" id="20325615"/>
    <dbReference type="KEGG" id="ovi:T265_11447"/>
    <dbReference type="CTD" id="20325615"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10858" checksum="E2E8152AC992E5D9" modified="2014-10-01" version="1">MKCGIMVKPRGIYGLRRHPNDKATGEGVECYGILFKSNIGLQRARPDSPPILFDGIHIEVQSVHFALRRPTVVVQICVGVRRFDPLADISYSVVAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ16</accession>
    <name>A0A074YZ16_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597102">
        <property type="protein sequence ID" value="KER20036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176219.1">
        <property type="nucleotide sequence ID" value="XM_009177955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ16"/>
    <dbReference type="GeneID" id="20325495"/>
    <dbReference type="KEGG" id="ovi:T265_11327"/>
    <dbReference type="CTD" id="20325495"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="17025" checksum="EFC89FF5E4BB927A" modified="2014-10-01" version="1">MGAVAGLNAKRFSSHGDGKDDGESGHSNRLEENVCGRIIGIGKEEKAEAHDVLISTLDVSFCAMECLPVGIFQGHYDLLVLRNDGAIEYVFSALFGILNYPLEQVGFGSGSIRPLFRCILPLAKLRPIHYFRPPTILNGIDVPPAIGDYERPLPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZB9</accession>
    <name>A0A074YZB9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597104">
        <property type="protein sequence ID" value="KER20018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176233.1">
        <property type="nucleotide sequence ID" value="XM_009177969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZB9"/>
    <dbReference type="STRING" id="6198.A0A074YZB9"/>
    <dbReference type="GeneID" id="20325506"/>
    <dbReference type="KEGG" id="ovi:T265_11338"/>
    <dbReference type="CTD" id="20325506"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="230" mass="26156" checksum="D5893AD02DA487CD" modified="2014-10-01" version="1">MLRCAPYYYADMKPGRSAPRASKDFQCLTIDVFGAMPESGGNTRSRMLNYIQRIAGLTSPDLINASKTPVVKLTTFVCPLRVEATFLIRNAAWITLPCYMPSTRPLKEPGGSERNINAREPPKTKIACRVFLIKLRIGTPREFEDKGIEESSAFFGMKPQSTDLQTKRVLKYVTDLAQDVKKIEKFISLLMRHMNGREWSITKRGKKLESVVPTEKQQSDKFKGFWRIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z027</accession>
    <name>A0A074Z027_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 38 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597829">
        <property type="protein sequence ID" value="KER18822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177431.1">
        <property type="nucleotide sequence ID" value="XM_009179167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z027"/>
    <dbReference type="STRING" id="6198.A0A074Z027"/>
    <dbReference type="GeneID" id="20329971"/>
    <dbReference type="KEGG" id="ovi:T265_15806"/>
    <dbReference type="CTD" id="20329971"/>
    <dbReference type="OrthoDB" id="2016903at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER18822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="388" mass="43290" checksum="E8F2145E6DAC4218" modified="2014-10-01" version="1" fragment="single">MYGFVFCSFSTQLNVMVPRNTYGAGVEQLRQQVAIVQHHDAVTGTEQQHVADDYVWRLNNAALPCKEFIGQAIGLLMVNELTTSTPWNAPKFCNERNISLCSVTDEEELSTPSSFRITLYNPLPWEIPDIWLRVPIHLGAYSTQVRVTDLSDPDSCKITHQLLEITNRTRSIPERQMARSSTDMDLVFRSVSDCAVPALGFRTYQVDVTPNIGSSLNDNGLEPEINSNARMLFKLSAIKTGVQIKATHRRSGKNFAVNVEMMYYRGSTSDGVSGAYIFHPKGEAIKWTAAETEVYSSGRQLIRRIRTTNLHDPIASNYYPVINRILIKGAGETSPESPPLALAVYTDRPQGGSSLEQGQLELMVHRRLVRDDGLGVNEALMEQGVDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z166</accession>
    <name>A0A074Z166_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597031">
        <property type="protein sequence ID" value="KER20683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175571.1">
        <property type="nucleotide sequence ID" value="XM_009177307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z166"/>
    <dbReference type="GeneID" id="20324996"/>
    <dbReference type="KEGG" id="ovi:T265_10828"/>
    <dbReference type="CTD" id="20324996"/>
    <dbReference type="OrthoDB" id="6244195at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="33852" checksum="E6470C6DC0C1420D" modified="2014-10-01" version="1">MEDVTEAARRQISKSNYKVKRWTLRRKLLKDDTEACVMSWNARRQLLYLLRTYEAEPFDEEFLASVFPITVAGIKKLASHKNEVFQPAMREQHKLRINTAAIERWNLILDCLKNLSKEPAQSVAEVNAVIASLPENLLWIFAQSKLHLLKHADGNPDLPSPQLSDVPEKRKEKEEVPGSFRELVDGFCNGFEPDLQSKQVALQSEEMEKCIALFQRIPDSTAVGPISNQPLSTSQLRSLLHISKLLTRQQVCTKPLALPNKVNLQFSDTFKYKLRYYRIFSAITLRRRHREHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2R5</accession>
    <name>A0A074Z2R5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596973">
        <property type="protein sequence ID" value="KER21356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174902.1">
        <property type="nucleotide sequence ID" value="XM_009176638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2R5"/>
    <dbReference type="GeneID" id="20329275"/>
    <dbReference type="KEGG" id="ovi:T265_15110"/>
    <dbReference type="CTD" id="20329275"/>
    <dbReference type="OrthoDB" id="10317612at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="361" mass="41740" checksum="98C8EAEE60397CE8" modified="2014-10-01" version="1" fragment="single">MTEDVPADYLVNAMQKIAVEEDGDTAPLSPPSPVPFEVGQFRRSEMLAYCTGKNRCLESKFRQTLLRYYRGHKQRVEKIDQGQSEIAAHLYRAYKARRTQQRKTRDELREIYGQSEWFHKFTEQTKKKAEEPESNAPKLPPVDVSLKSDDEARKRVKFTDKLRHSRSNTENKKERNKEPIPQESTFAVLLIEPHSFSPVQGIEIVFPKEVNDTQRSVTDWLSVAETTQPEIVATYPDDEGSHLPAGVEKSHPPFRSTGSLQTKYPNRHMAQVQEALAEEPRAYVWVGDKHQLICPVGRTAVRTDLVLRETSFPKPAHIRLLLPDSRQKYVNKKMCDQEFERLNESILKTKPFLERLETLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2W0</accession>
    <name>A0A074Z2W0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 4 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174937.1">
        <property type="nucleotide sequence ID" value="XM_009176673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2W0"/>
    <dbReference type="GeneID" id="20329283"/>
    <dbReference type="KEGG" id="ovi:T265_15118"/>
    <dbReference type="CTD" id="20329283"/>
    <dbReference type="OrthoDB" id="6269848at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="24793" checksum="18FF3DAF0E26F7AC" modified="2014-10-01" version="1" fragment="single">EEGIQTLYGSADSLTVNEVAETSRTAKRRPTPNELEFGLFVRRLTQDQLDHRLPITQQPRSILSQIEHACRREFPQFDSKQIRLKIRAQLKLHRRNIKRSQIRTSLNASKQLKRNRLRPLLPLTPLEGPSTSSTGPPVRPCPGISESSGQSDLYSQQAAKFDKDSALPNIFVNAMLPPIAISSLCNTLSPAMLFPQSFQGKSTPLQTTEAAYSIAGHPLLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3F3</accession>
    <name>A0A074Z3F3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596958">
        <property type="protein sequence ID" value="KER21548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174695.1">
        <property type="nucleotide sequence ID" value="XM_009176431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3F3"/>
    <dbReference type="GeneID" id="20324315"/>
    <dbReference type="KEGG" id="ovi:T265_10147"/>
    <dbReference type="CTD" id="20324315"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="14036" checksum="DEE9D3AECA722338" modified="2014-10-01" version="1">MGDIGWPTRRRQRLRNQDDVQGVSNYGFSIPRSIMQVMDPEAKIVKNPVVRTNRDWKTSKQLNRKQEFFFPLDTDNDVRQTCQSTRVPPQSTNNSPKVCSPAKGDIPIRIGKSAAAFLNLHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z451</accession>
    <name>A0A074Z451_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilium assembly protein DZIP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597071">
        <property type="protein sequence ID" value="KER20287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175968.1">
        <property type="nucleotide sequence ID" value="XM_009177704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z451"/>
    <dbReference type="STRING" id="6198.A0A074Z451"/>
    <dbReference type="GeneID" id="20325298"/>
    <dbReference type="KEGG" id="ovi:T265_11130"/>
    <dbReference type="CTD" id="20325298"/>
    <dbReference type="OrthoDB" id="515971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058883">
        <property type="entry name" value="DZIP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25977">
        <property type="entry name" value="DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilium assembly protein DZIP1" evidence="2">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="867" mass="97165" checksum="1BF2B3198AA82CF3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4Q7</accession>
    <name>A0A074Z4Q7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">T265_09754</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174188.1">
        <property type="nucleotide sequence ID" value="XM_009175924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4Q7"/>
    <dbReference type="STRING" id="6198.A0A074Z4Q7"/>
    <dbReference type="GeneID" id="20323922"/>
    <dbReference type="KEGG" id="ovi:T265_09754"/>
    <dbReference type="CTD" id="20323922"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KER22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="54887" checksum="04D884B2B084FB77" modified="2014-10-01" version="1">MDNSMPYSRQEDDNDRDVSQGCGASLACDPRRRLHRYMMLFFICFLSFGSYFCYDNPAALQDVMIRDLSLTETDFMNLYAWYSWPNVILSLVGGFLIDRVFGCPLGAIIFSLCIFLGQIIFGVGALVSNLPLMYFARFVFGIGGESLCVAQNTYIGEWFPASELNFVFGLQLSMARLGSTVNMNTMQLLYKSIGPYFGITGHLRLGTALLIASVTCIFSACCATILAFFTRRKDRILRAHNKRLADESASQIGKPPSQEVTQLISPKDILHFPAAVWLICVICVAYYVAIFPFVSLGQVFFERKFHLSLTQANVVNSLVYILSAVASPVFGATIDFTGRNLNWVLSSILLTLFCHLCFAFTSGVLPPMFIMILMGMGYSILASSLWPLVAFLLPPHQRGTAYGLIQSLQNLGLGVIAIFAGYLVDNKGYLFLEVFFTFCLSLALAVTFGLYLWDQKHGCLLNESGASRRRNEVREVDLSPEEEGALNDEANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z592</accession>
    <name>A0A074Z592_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596910">
        <property type="protein sequence ID" value="KER22238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174024.1">
        <property type="nucleotide sequence ID" value="XM_009175760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z592"/>
    <dbReference type="GeneID" id="20323798"/>
    <dbReference type="KEGG" id="ovi:T265_09630"/>
    <dbReference type="CTD" id="20323798"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12102" checksum="97369FBB67D91D81" modified="2014-10-01" version="1">MTKPKIAASRKSFRREANSSECNGLRFLGEDLRAKCAKLGGQIDGHGLTTRVGRAFKMMTLDTETQNRQVKQHMKYQRTLALWQRSNEEDETGHNLSHTHETQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5L5</accession>
    <name>A0A074Z5L5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599601">
        <property type="protein sequence ID" value="KER18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177678.1">
        <property type="nucleotide sequence ID" value="XM_009179414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5L5"/>
    <dbReference type="STRING" id="6198.A0A074Z5L5"/>
    <dbReference type="GeneID" id="20330132"/>
    <dbReference type="KEGG" id="ovi:T265_15967"/>
    <dbReference type="CTD" id="20330132"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15744" checksum="5093B9ED54729A83" modified="2014-10-01" version="1" fragment="single">MSDNSQFSYSVTEEQEQRRPNPPKLSASCILLPIKGLFWVQEDLPPDFPEWSPMGSVSHAARRKPANPVPAVTRDYMDPSKSGISRSDSSVKRPELNEPTEVNVRNSLRCYRFAHPSMGVELLYVFPDESAAMACLKLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z697</accession>
    <name>A0A074Z697_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173613.1">
        <property type="nucleotide sequence ID" value="XM_009175349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z697"/>
    <dbReference type="STRING" id="6198.A0A074Z697"/>
    <dbReference type="GeneID" id="20328970"/>
    <dbReference type="KEGG" id="ovi:T265_14804"/>
    <dbReference type="CTD" id="20328970"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8671" checksum="DA8ED3CE076098A8" modified="2014-10-01" version="1">MAAKLTDKEIADIFKVIDKDGNGKITKRELSKFFKNNKAEYSSKQIKTYIKSIDKDGDGKINLTELTTALRGCQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7C3</accession>
    <name>A0A074Z7C3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597330">
        <property type="protein sequence ID" value="KER19105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177145.1">
        <property type="nucleotide sequence ID" value="XM_009178881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7C3"/>
    <dbReference type="STRING" id="6198.A0A074Z7C3"/>
    <dbReference type="GeneID" id="20326171"/>
    <dbReference type="KEGG" id="ovi:T265_12003"/>
    <dbReference type="CTD" id="20326171"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER19105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="32759" checksum="FF8B167F1F0A1D68" modified="2014-10-01" version="1">MSFDISGSLNLTGFTTRRIIFIALSTVEILFLSLLSLFPSATLYVIALILCVALCLSTGACLGTDCTDVNFLPSLSAAISDEQPQRSIWMCFICISSSIRILLLFPVSRVYRRLCHTLGGAHLDWMVTPIFSLSTVEILFLSLLSLFPSATLYEAHRNCLAIFVFSSVMFMGFDTCLFIRMAQHSKNRTTVSEARRKSWLFASYLLLLTIIAAFYYVHTTYCPPYVYSLFSFFEYVAIVINVLYQYYANCLVGAVPMGVLLEHLSCSDKKTDRIDLAYFFNQQSSLATIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8A2</accession>
    <name>A0A074Z8A2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597201">
        <property type="protein sequence ID" value="KER19465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176786.1">
        <property type="nucleotide sequence ID" value="XM_009178522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8A2"/>
    <dbReference type="GeneID" id="20325938"/>
    <dbReference type="KEGG" id="ovi:T265_11770"/>
    <dbReference type="CTD" id="20325938"/>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="366" mass="40862" checksum="5DE0859BC320EAFF" modified="2014-10-01" version="1">MGTPRQATSMVRDIVRYGPVPPSMAVLLSQPPHPLDSPLTVLDSNNNLLAPACNAQLPLPPPKVIGEQNCGSYNHCTTNTRLLQLTTMMMMMSCNKISQLSPTKGDLAEGKVIYRFGCLCDSPSKIGSRRPILNLAGDVARNRRPSMPMTLCWLTSGLFLKIKYRIEVRLVYIDATNYELRLILKLLHWVAPVLIYSLVLAPKIHYASSRLFVTPIYVQTNHSSDLLRDTFHREPTTLLFTTKSLDIIILAEDLNSWVERLSSVGTRLCVLGDTQKPARRLALEKLCEQQVAEKVLCSALQATSVKDTDGKWDKVTKARHDDLVSPCSASERVHGCQWTSEQSVALNSLWFAVKFSWNIGWMTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8F6</accession>
    <name>A0A074Z8F6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596936">
        <property type="protein sequence ID" value="KER21852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174397.1">
        <property type="nucleotide sequence ID" value="XM_009176133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8F6"/>
    <dbReference type="GeneID" id="20324085"/>
    <dbReference type="KEGG" id="ovi:T265_09917"/>
    <dbReference type="CTD" id="20324085"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12696" checksum="93F476202A86F055" modified="2014-10-01" version="1">MPNSEWQKKRGGKSLTWKRGVKEITKLLGAVGATRFPGWGSRDPRCAWLETLPTDVSGMSLAIEALFGEKLLLSGRATLHRSPVFLSAHYGISKGTVALHSPLLRQRKIITTVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8H9</accession>
    <name>A0A074Z8H9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174363.1">
        <property type="nucleotide sequence ID" value="XM_009176099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8H9"/>
    <dbReference type="GeneID" id="20329156"/>
    <dbReference type="KEGG" id="ovi:T265_14990"/>
    <dbReference type="CTD" id="20329156"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="45119" checksum="6B4B7CFA490D3CFA" modified="2014-10-01" version="1" fragment="single">LNAEDEIIVIKETTHKVAENPLTAHDRFRPSSSGSSGRRSPRDSVNLVFYLNPNWTVFEKYTHLQINLMAQWWEREFTDRGSNPISAPRPPLSRLVQPGNIPALVQPSSGMAVRHLKGETAERFTHSFIWYVGETFLATTYTWLSGRSANSLTVVQTRSLPLVLPCLGLCNLAISQPSCNLRVAWQLGTLRVRQRNDLLIHLFGMWGRRFSQPLTLGTIFEISQCIFVKETTHKVAENSSTARDRCHRTPKRAKPVVGCRRVFSNLVGCFLYEKNNRYSTLLWNVATYTQIAHLAACSIAKQKLKTTLASAHSVSACVAREQNCPAVAPFRCLTVMPPKGCTRAGILPGCPSLGRRSREAEVKFEPRTFRSVNSRSNHLGYLTPQRGTWLIQQIRQCNTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8X9</accession>
    <name>A0A074Z8X9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172586.1">
        <property type="nucleotide sequence ID" value="XM_009174322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8X9"/>
    <dbReference type="GeneID" id="20322680"/>
    <dbReference type="KEGG" id="ovi:T265_08501"/>
    <dbReference type="CTD" id="20322680"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7760" checksum="D7217ACFF58A7315" modified="2014-10-01" version="1">MSYQQGTVPCVPPTFNIFGKHEDDLMCFLQAKHMWTCNSAHEYAAIASPNARIPATTDASSVSMKTQPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z915</accession>
    <name>A0A074Z915_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_09730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174159.1">
        <property type="nucleotide sequence ID" value="XM_009175895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z915"/>
    <dbReference type="STRING" id="6198.A0A074Z915"/>
    <dbReference type="GeneID" id="20323898"/>
    <dbReference type="KEGG" id="ovi:T265_09730"/>
    <dbReference type="CTD" id="20323898"/>
    <dbReference type="OrthoDB" id="8918594at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER22077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="384" mass="43442" checksum="2DA4498C13ACA8AC" modified="2014-10-01" version="1">MNNTLKQEDLDLSAVIQSTAFGSRGAELMQQNESTGVLKNTAEQLLAKIITAASNQIKTEEPDINMADGIVGRSTSMGLLLQDNSDSPTLTDKPMFRALPNEMDSTSGPSETTPNPPQGRYCCSICSQRFRSHTGLRRHNLDAHVAQAVNCDQCSKVFRDTTSLTDHKKRVHGPREYVCGICSADFASESYLRTHVRIHEEKRFSCVECTHSFCNPTDLKNHMRVHNGEKPFACEVCGKAFRHVSGFYAHIRIHTGETPYNCPLCDKKFSNASNFRMHTKVHTKEMQFRCETCGKEFIQPSNYSRHLRIHTKERPYACNLCSAQFPYSTSLKRHQQRQHGMELLQCRACQKTFLNESSFVRHRTGCELRGCVNFTGAEMCTQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z981</accession>
    <name>A0A074Z981_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172588.1">
        <property type="nucleotide sequence ID" value="XM_009174324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z981"/>
    <dbReference type="GeneID" id="20322682"/>
    <dbReference type="KEGG" id="ovi:T265_08503"/>
    <dbReference type="CTD" id="20322682"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12784" checksum="4338FFF74A62FBD8" modified="2014-10-01" version="1">MRPGQLVLHISDATNDPIKVLFIFYKYPDFSDQMQQLWSSPADPEGIATELTVCCFPEKSSTWPAAMINVLGCQANEVVRVDITEKVVPPLHKDKRQLTYDSSMDMHTKRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9U8</accession>
    <name>A0A074Z9U8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172342.1">
        <property type="nucleotide sequence ID" value="XM_009174078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9U8"/>
    <dbReference type="STRING" id="6198.A0A074Z9U8"/>
    <dbReference type="GeneID" id="20322491"/>
    <dbReference type="KEGG" id="ovi:T265_08312"/>
    <dbReference type="CTD" id="20322491"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="416" mass="47228" checksum="30F2AF102CD0F938" modified="2014-10-01" version="1">MTEAVVGDQSSFTSDLGIIVKPRPRRPKSYFVRFVEFSSVCQWVTGFLFFGISCYAVFMYLIYSMLKHLVLFVWFSVSEPHEDWFVYSITSWDKMEALYTSVLAALVGLYLYYWQHDLRAEERGSHPRTWLRNLWLWKRMADYFPIQLVLSDELLKSEHAEAAVDCKSGNQLGGFGGLSTKRNYMVGYHPHGVFSTGAFVNFMTEATGFSLAFPGLTPWLAVLKAHFKSPFYRDYLMALGIIAATKRGLRYLLDAEECGKTGNFVVVVVGGAPEALEAKPGQYRLVIRQRYGFFKLAIQTGQRARCCSKGTCCAQPHQEWYSNALFPAPSGWANTLQPSRWSNNDLAAKYVSHYQQTQLRWSLPSSWMGTPRRATSMVRDIVRHGPVAPSMALVHQSYCLQCIAPFPAPDPHLTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAD2</accession>
    <name>A0A074ZAD2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_15378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597084">
        <property type="protein sequence ID" value="KER20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176081.1">
        <property type="nucleotide sequence ID" value="XM_009177817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAD2"/>
    <dbReference type="STRING" id="6198.A0A074ZAD2"/>
    <dbReference type="GeneID" id="20329543"/>
    <dbReference type="KEGG" id="ovi:T265_15378"/>
    <dbReference type="CTD" id="20329543"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000256">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="457" mass="52177" checksum="DA4997BE5213143A" modified="2014-10-01" version="1">MPESDAENRDFRIFGIRRLSHFKIPQEYREGRCRSVAEFEKLNRIGEGTYGIVYRARDTVSKEVVALKKVRMENVRDGIPISSLREITLLLSLKHQNVVHLREVVVGRGLDSIFLVMEYCEQDMASLLDNMPNPFTESQVKCIMLQLFKGLRHLHENFIIHRDLKVSNLLMTDKGMVKIADFGLSRPTHSHNPMTPCVVTLWYRAPEVLLGDKNQTKAIDIWSSGCIMGELLLHKPLLPGQSEVHQVELIIDLLGTPNEQIWPGMSKLPALEKINLKKQPYNNLRHTFPWLSDAGLRLLNFLFMYDPAKRARARECCQSSYFREHPLPCEPDMMPSFPQHRLKRKGSPVDDGKGPVSQQHNASSGLFDAAFDRIVSEETPTLKIIHSNKLCASTLFASFGFKGTYVEHLMSVTLIDFMNEDVDVPNSPFVTFRILNADVLMHDHAVDCRQMMDVHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAK2</accession>
    <name>A0A074ZAK2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171946.1">
        <property type="nucleotide sequence ID" value="XM_009173682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAK2"/>
    <dbReference type="STRING" id="6198.A0A074ZAK2"/>
    <dbReference type="GeneID" id="20322180"/>
    <dbReference type="KEGG" id="ovi:T265_08001"/>
    <dbReference type="CTD" id="20322180"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73990" checksum="12142993CD8CDFCB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBJ0</accession>
    <name>A0A074ZBJ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173281.1">
        <property type="nucleotide sequence ID" value="XM_009175017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBJ0"/>
    <dbReference type="GeneID" id="20323227"/>
    <dbReference type="KEGG" id="ovi:T265_09048"/>
    <dbReference type="CTD" id="20323227"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="17818" checksum="8E6B4B09476CEAF8" modified="2014-10-01" version="1">MYRDISNIVATETCGGLVQHIQSPGYIKTGRFSWVPGESLKKKQISLQMSVYSNIRLTETQRLRLPDEPQEERNRPWAVEAFSATLEKNRSAVAPFRCLTAMSSRGSTRTGIVPGCPSLDMEIREAEVGSVNLRSNHLSNLAPNQHREALRHNRLMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCF0</accession>
    <name>A0A074ZCF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596857">
        <property type="protein sequence ID" value="KER23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172978.1">
        <property type="nucleotide sequence ID" value="XM_009174714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCF0"/>
    <dbReference type="GeneID" id="20322986"/>
    <dbReference type="KEGG" id="ovi:T265_08807"/>
    <dbReference type="CTD" id="20322986"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9202" checksum="C18F42764DBCFCAE" modified="2014-10-01" version="1">MKNQQTPQLYQLPHPLRTHLHHVPKSPANETVAAKTCVQQNNSTRLLPQSSLHPSHLHTAHIFSDPERAVTSAVIRAVECQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCX5</accession>
    <name>A0A074ZCX5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171211.1">
        <property type="nucleotide sequence ID" value="XM_009172947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCX5"/>
    <dbReference type="STRING" id="6198.A0A074ZCX5"/>
    <dbReference type="GeneID" id="20321608"/>
    <dbReference type="KEGG" id="ovi:T265_07429"/>
    <dbReference type="CTD" id="20321608"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="373" mass="41630" checksum="A10DE6E4966A0DE7" modified="2014-10-01" version="1">MIRRTFSRITRMDFQILYGAYVRPLLEYANQVVYSERTKDVSLIERVQRAATRMVAGLKSVDYETRLAMLDLFPLEYRRLQGDLILTHALFEQSLADRFSIVDLSNTRGDVFTRAGDSNFSGGTRRHREMAAKDGRESEGSDGGEEEFQVEKILKVRIRGGRKEYFLKWKGYPDEDNTWEPEENLDCPELIKEFEEKRAREKPVGASPARSSSGGDAGRPRSRPKGAPSTPQSAQKQNEDVSEPPKKKRAAVPSDADAAADAAGDEAGKPDDDSKTKTPKSAGKTRGFGRGLKAERIIGATDSSGELMFLMKWKDSDEADLVPAREANIKCPQVVIRFYEERLTWHTPESRTSSGTPRPNATTPTSATNTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD79</accession>
    <name>A0A074ZD79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171016.1">
        <property type="nucleotide sequence ID" value="XM_009172752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD79"/>
    <dbReference type="STRING" id="6198.A0A074ZD79"/>
    <dbReference type="GeneID" id="20321453"/>
    <dbReference type="KEGG" id="ovi:T265_07274"/>
    <dbReference type="CTD" id="20321453"/>
    <dbReference type="OrthoDB" id="10056584at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14587" checksum="9F52788CB29086D1" modified="2014-10-01" version="1">MYREVANLIDFKIEFVICMVCGQSIEYEGTLGDPEGGMQVGVNVAAKDRGSIREDLHCSPAELVYGTTLRLPGELVSPSGAQPESPDTFVSRLKQHMSELRATPTRRSTRTEHISADLSSTSFVLLLTDELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF70</accession>
    <name>A0A074ZF70_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174361.1">
        <property type="nucleotide sequence ID" value="XM_009176097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF70"/>
    <dbReference type="STRING" id="6198.A0A074ZF70"/>
    <dbReference type="GeneID" id="20324055"/>
    <dbReference type="KEGG" id="ovi:T265_09887"/>
    <dbReference type="CTD" id="20324055"/>
    <dbReference type="OrthoDB" id="6273183at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10936" checksum="1F024B230922DFE9" modified="2014-10-01" version="1">MSDRDKGGKTRVKAKTTSLPTGLQFPVGPMHLLLRKGNSAGAPVYLATIPECLAAEVLELAGNVGRDNMKIRIIAGRDNMKIRIIPRYLQLAIKQRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGH1</accession>
    <name>A0A074ZGH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169885.1">
        <property type="nucleotide sequence ID" value="XM_009171621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGH1"/>
    <dbReference type="STRING" id="6198.A0A074ZGH1"/>
    <dbReference type="GeneID" id="20328176"/>
    <dbReference type="KEGG" id="ovi:T265_14009"/>
    <dbReference type="CTD" id="20328176"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="4">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10387" checksum="A12687F86BD90BFB" modified="2014-10-01" version="1" fragment="single">SEYAKPLSVSITPCNTYYCVLQRGKPTTFEITFQAFDDLEAAGVEVSAIFKTVMMLVTFPNANVCDRLNPPCPIRARQTYTYSYTTAIAESFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH48</accession>
    <name>A0A074ZH48_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169644.1">
        <property type="nucleotide sequence ID" value="XM_009171380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH48"/>
    <dbReference type="STRING" id="6198.A0A074ZH48"/>
    <dbReference type="GeneID" id="20320361"/>
    <dbReference type="KEGG" id="ovi:T265_06179"/>
    <dbReference type="CTD" id="20320361"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.470">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015143">
        <property type="entry name" value="L27_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09058">
        <property type="entry name" value="L27_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="320"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="433" mass="46820" checksum="F72CDF5A66C0F610" modified="2014-10-01" version="1">MSRFSLSQEVDYVAQKVWGYFLEGEYAVERRFINRAIFSVDGRGETVDTARALELLGSLRERLSNDENKSLKNAVDKLITAIENPLFSSLMDVHEYYLTMLGADVDSASSRPSSSKTNNQSSVGSRMNGSVLSPKQPSSNVPQSSAGSTVKQNPDWEYLEVVLKRETLSPGGFGFSIAGGIDFPVAEADAGIYVTRIAPNGCADVDGRLRVDDQILAVNGISLEHVTNMEAVQTMKRAGDSLHLILAVNGISLEHVTNMEAVQTMKRAGDSLHLVVRRYHGGKAASASVNSSSTPRSTSVRSPELLSELDESGDTPVWFEVQLRKPTPDTSLGMSIAGGREAEDDPNALPVPGIFVTRVTPNGLAQRDGRIMPGDQLMQVNGVDVSQMSHADAVQVLRTAGLVLNLVFTRFPQPGESELAAPSIDSADSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHG0</accession>
    <name>A0A074ZHG0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173609.1">
        <property type="nucleotide sequence ID" value="XM_009175345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHG0"/>
    <dbReference type="STRING" id="6198.A0A074ZHG0"/>
    <dbReference type="GeneID" id="20323489"/>
    <dbReference type="KEGG" id="ovi:T265_09316"/>
    <dbReference type="CTD" id="20323489"/>
    <dbReference type="OrthoDB" id="6237065at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10283">
        <property type="entry name" value="MnuA_DNase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="498" mass="55135" checksum="BD9D7511F846E4FB" modified="2014-10-01" version="1">MSVFRMLCCIPLAYGQSEAKRSNLRTLREILLYLDEADEEQQRDINLFIYQLLTQLAATESTGRASDSVRSPFNAPLIDRHALSAFREAVKRLVSHPPTRATDQPTDQAHSLSSSSPTRTNDFADTLPPWTSVKSDSVFRHNIIIEMLSRCPLALLELLFQMESVKSWNELLAASNLTNYVALELPTPCTSSYGGQVRIASWNLNRFTLAKARHPGFREVLCLTILRSKISLMVLQEVASVDVADVLCAELNSPTLPHVRKWAHDHPPWCVPKWKVASSTQAVGSMFAGREYALFLYNENAGVCISRTSLMEPPTVAKSLKVFSRSPCPALCKIRSARLILVSVHLKARGLRNSRIGRTAAEVQALETVVQAFYDTQSPQSHLVILGDFNLNPEHEAFSRLRERGFQSVLNGYQATTPQSNLKDQSDSPSSTLCPTAYDNAWISPSLISVDTTDSSYTGNSGVITSGLRHPLIPGDIGAGANGFISDHCPIWFDLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHM9</accession>
    <name>A0A074ZHM9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_14248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171029.1">
        <property type="nucleotide sequence ID" value="XM_009172765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHM9"/>
    <dbReference type="STRING" id="6198.A0A074ZHM9"/>
    <dbReference type="GeneID" id="20328414"/>
    <dbReference type="KEGG" id="ovi:T265_14248"/>
    <dbReference type="CTD" id="20328414"/>
    <dbReference type="OrthoDB" id="6159198at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000029">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 11" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="589" mass="67507" checksum="92B1B3AF0C2BD37D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP7</accession>
    <name>A0A074ZHP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596782">
        <property type="protein sequence ID" value="KER25257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170980.1">
        <property type="nucleotide sequence ID" value="XM_009172716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP7"/>
    <dbReference type="GeneID" id="20321421"/>
    <dbReference type="KEGG" id="ovi:T265_07242"/>
    <dbReference type="CTD" id="20321421"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19165" checksum="25E8FF1E2B8E1777" modified="2014-10-01" version="1">MAVGHRKGVTAERFFAHGAEEFVCTHLTVRLADGKMLIPTLSVLSGGQIPLTERTEQTVSWKISKTPSAGSIQPRVRFSNLGGNLWLGSFQDIQPNKLDATGVITKGHSTTACNEGKLRQSAEKAFPGLGSESLEFKERIRNHQCVVVLRLPKTLEAVNQDQIFQELSTNATVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHS6</accession>
    <name>A0A074ZHS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170908.1">
        <property type="nucleotide sequence ID" value="XM_009172644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHS6"/>
    <dbReference type="GeneID" id="20321367"/>
    <dbReference type="KEGG" id="ovi:T265_07188"/>
    <dbReference type="CTD" id="20321367"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="309" mass="34765" checksum="F6ACEAC481BE4F2E" modified="2014-10-01" version="1">MRSKEEQCNRDKEKATKLIDNLEEDYTVKSFRIHVKDLASLRGGEPTPSTIGLTWTSGLCIFGKPWLDCTSGVQSIPMILPQMVYHGPQISANYSLTLIQYRRNIPTTGLPLKIHVNINVLLTSVLSDRGITKRKTSDLYNHNKDKLESAGKSVKTVYVTVYWTTVMLCENSPLRKSADWHTEHVAKPAQPMKCDQFIYPGRVISSENHLTYFIIKDPNHRPMATLPNNAVMMSPPLYAVCLGASYVCNLVTFDDQLPSQDARNQGQHNIRIVGVPGYYAIFTQDQPTELPLGRLQFSVSLRVLNTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIC3</accession>
    <name>A0A074ZIC3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TRAF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169526.1">
        <property type="nucleotide sequence ID" value="XM_009171262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIC3"/>
    <dbReference type="STRING" id="6198.A0A074ZIC3"/>
    <dbReference type="GeneID" id="20320266"/>
    <dbReference type="KEGG" id="ovi:T265_06084"/>
    <dbReference type="CTD" id="20320266"/>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.150">
        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF20">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44732" checksum="9E94D90AA42077AE" modified="2014-10-01" version="1">MAFCVDHCLWCITSSCSRSDGYCAVVDCPNFCGMRMHLCKAQEHTEHICANTVVACPNREIGCAVTVLRRKVATHLSACQASVVSCFVPGNIPVRPTISKTTPGFFRRPFLTKALKPVRPAFVFNAASTASSTQSISSLTDPPNGHSTQTLGEESTESPDEFVEQPVLPFFSGSEGEHFCQKIVPRSNFNNHWRLHADVLRQLDGFIELRCPLHWRGCRFVAVLLRPTGPNGRLLYNPAMGLFAIDVGGTNVPVDKSSACMSGDILVGRSTLRLDELPEDVLIRLTRTLDNASLLCLCEAAQSNSRLRALAESAIRGRLIVLPNWVRFSYPPNSGNSGWKITEFVYCLPEQSTCVSKWSFNLGRSDLTRHLRTCPFNDRRVNEKPFALIRGGLTENDMVPLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZII9</accession>
    <name>A0A074ZII9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169437.1">
        <property type="nucleotide sequence ID" value="XM_009171173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20320196"/>
    <dbReference type="KEGG" id="ovi:T265_06014"/>
    <dbReference type="CTD" id="20320196"/>
    <dbReference type="OrthoDB" id="6243832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146399" checksum="A7C87398EA46748C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ09</accession>
    <name>A0A074ZJ09_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596854">
        <property type="protein sequence ID" value="KER23330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172930.1">
        <property type="nucleotide sequence ID" value="XM_009174666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ09"/>
    <dbReference type="GeneID" id="20322953"/>
    <dbReference type="KEGG" id="ovi:T265_08774"/>
    <dbReference type="CTD" id="20322953"/>
    <dbReference type="OrthoDB" id="6259454at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="610" mass="69541" checksum="4E20D41D5329DCB7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ49</accession>
    <name>A0A074ZJ49_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170460.1">
        <property type="nucleotide sequence ID" value="XM_009172196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ49"/>
    <dbReference type="GeneID" id="20321001"/>
    <dbReference type="KEGG" id="ovi:T265_06822"/>
    <dbReference type="CTD" id="20321001"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="13589" checksum="D4833BAC8610A32D" modified="2014-10-01" version="1">MVRSSVVREGTQSGRKFTEHLNELVKSTGQDSLRPVCLGQANNRSAVTPFRCLAATPHEGDTRAEILPGLPSLDRGSREAEVGFELQAFRSVNSCSNHLVHLAPRSQANRFCLTRRCGSQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ94</accession>
    <name>A0A074ZJ94_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596764">
        <property type="protein sequence ID" value="KER25842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170378.1">
        <property type="nucleotide sequence ID" value="XM_009172114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ94"/>
    <dbReference type="STRING" id="6198.A0A074ZJ94"/>
    <dbReference type="GeneID" id="20320940"/>
    <dbReference type="KEGG" id="ovi:T265_06761"/>
    <dbReference type="CTD" id="20320940"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000021">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="64025" checksum="24BDB00B18616940" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJD6</accession>
    <name>A0A074ZJD6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170356.1">
        <property type="nucleotide sequence ID" value="XM_009172092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJD6"/>
    <dbReference type="STRING" id="6198.A0A074ZJD6"/>
    <dbReference type="GeneID" id="20320926"/>
    <dbReference type="KEGG" id="ovi:T265_06747"/>
    <dbReference type="CTD" id="20320926"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="383" mass="43696" checksum="CC6554312F717763" modified="2014-10-01" version="1">MSEYSWKDTNLALVGSEEDRNVKKKAAETEPAWKDVLSIDSTTTLVWRINQFKVEEVKKETFGKFFSGDSYIVLHTEKTGNQLLYDVHFWIGKDSTQDEYATAAYKTVELDTLLDDKAVQHREVDGFESDEFKSYFPVLEKLAGGYATGFRERKPEELPKRLLLCHGLDRRHVELTEVTFSRKSLNSNDVFILDLGTKAYQWNGQNASKDERFKASEFMQALESQRMGRCPTVVVDESDREGTNEFLSYLPDEPVHEKPKQETEKKAIYRLSDESGQLKVTLVCENNLPRGALTHDDAYFIDNGNTLFVYIGTKCSKTEKLNALAHAHVRDAGYVHVHAPENVSHLPGETFSREYLKGTKHPLIPITVVSEGRQSKELDKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJN8</accession>
    <name>A0A074ZJN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170247.1">
        <property type="nucleotide sequence ID" value="XM_009171983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20328254"/>
    <dbReference type="KEGG" id="ovi:T265_14088"/>
    <dbReference type="CTD" id="20328254"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057347">
        <property type="entry name" value="TANGO6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25267">
        <property type="entry name" value="TANGO6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 N-terminal" evidence="4">
        <location>
            <begin position="1246"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="2062"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2334" mass="257406" checksum="B523578CCF27BAD3" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJQ5</accession>
    <name>A0A074ZJQ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172688.1">
        <property type="nucleotide sequence ID" value="XM_009174424.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZJQ5"/>
    <dbReference type="GeneID" id="20322758"/>
    <dbReference type="KEGG" id="ovi:T265_08579"/>
    <dbReference type="CTD" id="20322758"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="1648"/>
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        </source>
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    <sequence length="1648" mass="164930" checksum="A55C03FC0BEDCAD1" modified="2014-10-01" version="1"> </sequence>
</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Hu M."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER27913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8342" checksum="201DE9AF3A3D98CC" modified="2014-10-01" version="1">MGQRTIGGTLNHMHLVIRAPPAGCAYKFSCSTLSVPNCQATRRLHKGWDTARGSRGRGRARTMDLPGHLSVKPEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKT2</accession>
    <name>A0A074ZKT2_OPIVI</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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                <person name="Nagarajan N."/>
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                <person name="Hall R.S."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20319542"/>
    <dbReference type="KEGG" id="ovi:T265_05360"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8674" checksum="0250215E84EDE951" modified="2014-10-01" version="1">MFIDLMRVDKSGILKRAAASNDASEVRNAPSRQGKEALRQEEQYANYNSSNLKVSPDSAHLGSQKRLEFVASCSRCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLR9</accession>
    <name>A0A074ZLR9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169583.1">
        <property type="nucleotide sequence ID" value="XM_009171319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLR9"/>
    <dbReference type="STRING" id="6198.A0A074ZLR9"/>
    <dbReference type="GeneID" id="20328120"/>
    <dbReference type="KEGG" id="ovi:T265_13953"/>
    <dbReference type="CTD" id="20328120"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="404" mass="44530" checksum="B12FFC27EEA939AA" modified="2014-10-01" version="1" fragment="single">MIESPNRSMIHEAVKLGDLKSVKKMISEGADVNEADDQSFTPLHWATNVLQYLLWKGADPNIVTTRGWCALHIAAIRGYEPCIQSLVDRGVCLSTQDSHGLTPGHLAAIHGNSGCLLALLKSGADVETVDGHGWTMLHCAAFHGRLGCVQVLLRWGLRVEDVDKSGNSAVHLAAMEGHLPVLQCLIIQHPTPLLLLDTPNDLGETPESLSKRFLKEDVSGFIETVKKEHGLRPVDEARFFATAFPAHSAAYDGDLTTLRTLIEEGVIKVNERDEQGSTPLHKAAGQGHVKIIHWLLENGADPSITNHLGERPVDVARRFGQSAAIEPLKVRDPHNMVSEKIPGFLEGEPEPEVILDKEIALERARKRIDKFQKLLDLAKSDYKQLGGEPDPEELHIQCEIRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLV4</accession>
    <name>A0A074ZLV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167909.1">
        <property type="nucleotide sequence ID" value="XM_009169645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLV4"/>
    <dbReference type="GeneID" id="20318989"/>
    <dbReference type="KEGG" id="ovi:T265_04807"/>
    <dbReference type="CTD" id="20318989"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12721" checksum="EBF5AA3CDDCD5DF7" modified="2014-10-01" version="1">MLHTGHLMFQLARYSRYRTERRRDGQYVLVFDYAGFSTLMRASRVPYALKEAILNSTYFFLYECNSSTTGLPVHEIMSTVEVITPGLEVTTMALDFRTPSVPLKWFSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLX5</accession>
    <name>A0A074ZLX5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reticulocalbin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_04760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCSK6 (immature form including the propeptide); probably involved in the maturation and the secretion of PCSK6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167849.1">
        <property type="nucleotide sequence ID" value="XM_009169585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLX5"/>
    <dbReference type="STRING" id="6198.A0A074ZLX5"/>
    <dbReference type="GeneID" id="20318942"/>
    <dbReference type="KEGG" id="ovi:T265_04760"/>
    <dbReference type="CTD" id="20318942"/>
    <dbReference type="OrthoDB" id="6223661at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16227">
        <property type="entry name" value="EFh_CREC_RCN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000104">
        <property type="entry name" value="calumenin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF95">
        <property type="entry name" value="LD34388P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704240" description="Reticulocalbin-3" evidence="12">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER28373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="333" mass="38810" checksum="789B4B5E111A78D9" modified="2014-10-01" version="1">MYSSQFPLLFICIGICVWIEKSQSDEFENLDVLMNEHLRPDEPQIPTSGPVHFNAFGQRDFDLDHEVVLGSFEQTQYFKQLEPEEAKTRLGQLFEKMDANQNGNLDKNELIDWIVQSFTNLDLESAKIKLNDYDADQDGTLTWEEYTTRVYGYSSTELEQLAKDSSNETQAFLRSIEEEKIKFKSADLDQNGHLNATEFTAFEHPHNYPHMAPYEIIHTLRDFDTDNDGFISQQEYLADDKMHREAFKIELENFKRYDTNGDGRLDQEEMKHWVTPGFQRTATEEAEHLFSETDANGDKELSKEEVLAQHELWVGSQATDYGRHLEHSIRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN90</accession>
    <name>A0A074ZN90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167418.1">
        <property type="nucleotide sequence ID" value="XM_009169154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN90"/>
    <dbReference type="GeneID" id="20327674"/>
    <dbReference type="KEGG" id="ovi:T265_13507"/>
    <dbReference type="CTD" id="20327674"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16785" checksum="68E40CDB9D415E3D" modified="2014-10-01" version="1" fragment="single">SGNAQQAFTCYTCTDCQLPIDENTAKSGSTCGACKQLTFSRNQCFSLTISPRLVIRRLQFNCQARRTDQQSSSAFELPTTNNIASMKFVEIFEFYLIENVNYFNALADGRVVSFNSIIDKGEGHQENLFVVVRSGLEHPREITVNLIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNS4</accession>
    <name>A0A074ZNS4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167458.1">
        <property type="nucleotide sequence ID" value="XM_009169194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNS4"/>
    <dbReference type="GeneID" id="20318627"/>
    <dbReference type="KEGG" id="ovi:T265_04445"/>
    <dbReference type="CTD" id="20318627"/>
    <dbReference type="OrthoDB" id="6745818at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="34500" checksum="E2D2756FA06ACD86" modified="2014-10-01" version="1">MLPRMYPSTCDNLWPEYSRSMSARRGLWPQMIQPDSVEETNHKVAEISSTAHDQFCPSLSSSGRRNPRVSLNPRLTFANHIHLHIKMSSAEFIWASRENQIPVQMRVLTSCLYYVAYSSYAESWLGRTPFRCQTATQPERNTRAGILPEEVERQRSGSNHGRTGPWFEPDLCLLTSLSRLEQTGSIPALVPTVSGVAAKHRTGVTDERGLLHESARIRKTRAAFINLRHLWRQIRVVLLYGCETWPIRALSLRLLQVFDNRCLRTIARVGWCRRIRNEAVRERVSGWGPRDPHCAWLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPB5</accession>
    <name>A0A074ZPB5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167014.1">
        <property type="nucleotide sequence ID" value="XM_009168750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPB5"/>
    <dbReference type="GeneID" id="20318290"/>
    <dbReference type="KEGG" id="ovi:T265_04104"/>
    <dbReference type="CTD" id="20318290"/>
    <dbReference type="OrthoDB" id="6222219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="20486" checksum="9220D81914F62D7A" modified="2014-10-01" version="1">MTQISAEDRDFLILLYYKLEELKGTVVTAEYEEMLLKYDFTTTSARKVASQFDPERQKIITREQIYRVLNCPGNYMPKMSIPRDISILSSDMGPYLQYFVIHMARKIMKYLPDMKEVVSRIKMRLDSLYGPLWHVFIVRGQYWAYYSHDTRTGLVFKKDDLIYLMYRSPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPM6</accession>
    <name>A0A074ZPM6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166907.1">
        <property type="nucleotide sequence ID" value="XM_009168643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPM6"/>
    <dbReference type="GeneID" id="20318211"/>
    <dbReference type="KEGG" id="ovi:T265_04025"/>
    <dbReference type="CTD" id="20318211"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11504" checksum="1CD1641C4BDF7516" modified="2014-10-01" version="1">MRPCDAVHPLLPVAAVVDTQTGSAKTSLRDVEKRECYQTVEASISLKKTYMINTSIAHRTAGHLNPAKGEPHAYTIPAARFTSAPGKHQDFQGVNFVPNPTYASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPV0</accession>
    <name>A0A074ZPV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cellulase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167150.1">
        <property type="nucleotide sequence ID" value="XM_009168886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPV0"/>
    <dbReference type="STRING" id="6198.A0A074ZPV0"/>
    <dbReference type="GeneID" id="20318390"/>
    <dbReference type="KEGG" id="ovi:T265_04204"/>
    <dbReference type="CTD" id="20318390"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704250" description="Cellulase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="34"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="407"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59984" checksum="4433D04E69E6DCE8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQN3</accession>
    <name>A0A074ZQN3_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166782.1">
        <property type="nucleotide sequence ID" value="XM_009168518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQN3"/>
    <dbReference type="STRING" id="6198.A0A074ZQN3"/>
    <dbReference type="GeneID" id="20318104"/>
    <dbReference type="KEGG" id="ovi:T265_03917"/>
    <dbReference type="CTD" id="20318104"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15857" checksum="70259690055442EC" modified="2014-10-01" version="1">MTPSRHYPFLAPGFSHQYVPKTLAVFAELQEKITDMDEEARDLHQIRQFVRQRYEANWKFCPSGLEWGCNNSPYNSDKDDNRLDCCSMGYAAITNDGEVASPEGNRRSVCSSLDSKASPDDNGAHSHCSSFVRSSGATNLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQP7</accession>
    <name>A0A074ZQP7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQP7"/>
    <dbReference type="GeneID" id="20318124"/>
    <dbReference type="KEGG" id="ovi:T265_03938"/>
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    <dbReference type="OrthoDB" id="6257971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="377" mass="41961" checksum="A380DFCAE7D5B522" modified="2014-10-01" version="1">MSTRMVTKRLQINCQARRTDQQPPDHLPTNIIFSSSFLAIVVSGNILSMSKQAFVPSSVTGRKMSANPSNQRTMQPMPPRPRRVTTMTAGVRPTQPSSSVRHSSPKFDRRHDATDLVLNDSVASAITSISACGNPVRRRSLSSGSLTSTSVSPSTKTPVHCGQSDILSLHQAVLTEWAMVHQRLSELTTAQKESELNKVKQLLTNCEERLEELRAVRKAHAELTNFLRVTKALEAENSLLLSLISLLRPNVALDAANLVSNPSNPSVLDRLKKLTLEELKPNYERLPLQQFTLTEDVHEAVFPHVHQFVLHSEHELQKLEELATIIEETADRLETTTVPLARCQAEQVIEASQLLANEASLRFERLQRILPTSESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQS1</accession>
    <name>A0A074ZQS1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166475.1">
        <property type="nucleotide sequence ID" value="XM_009168211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQS1"/>
    <dbReference type="GeneID" id="20317856"/>
    <dbReference type="KEGG" id="ovi:T265_03669"/>
    <dbReference type="CTD" id="20317856"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8372" checksum="C781FF3DB3884715" modified="2014-10-01" version="1">MYKNHHERHGLINCEMQGNGSQKTLNVGEKRLVHQTQQGLIIKLVFLWEIRMVNGQITSPPERSTTNSEDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR08</accession>
    <name>A0A074ZR08_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Synaptonemal complex protein 2 Spt16M-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166698.1">
        <property type="nucleotide sequence ID" value="XM_009168434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR08"/>
    <dbReference type="STRING" id="6198.A0A074ZR08"/>
    <dbReference type="GeneID" id="20318040"/>
    <dbReference type="KEGG" id="ovi:T265_03853"/>
    <dbReference type="CTD" id="20318040"/>
    <dbReference type="OrthoDB" id="10256849at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024835">
        <property type="entry name" value="SYCP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607:SF18">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="137944" checksum="C9116CE3B8D7AAC9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSC4</accession>
    <name>A0A074ZSC4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inhibitor of apoptosis-promoting Bax1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165969.1">
        <property type="nucleotide sequence ID" value="XM_009167705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSC4"/>
    <dbReference type="STRING" id="6198.A0A074ZSC4"/>
    <dbReference type="GeneID" id="20317459"/>
    <dbReference type="KEGG" id="ovi:T265_03272"/>
    <dbReference type="CTD" id="20317459"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26564" checksum="983E41D799C408FE" modified="2014-10-01" version="1">MSSVRPDIEAPSHPLEKDFAFRNNVAQAHVSIRNGFLRKVYGILFTQLAVTALVAGAMFYVRQPLLEASAFGGLSLLSAFLAFGFLIALAFKKHETPLNYILLFGFTLLESFAVGSIVLHYSGTIVLQAVGLTALATFGLMSYTFQTKRDLSQWGSGLCVALLLLIIAGPINFFLGSSLFEFSLSIGGALLFSLLIIYDTHRIMHHCSPEDYIVACIDLYLDILNLFLYLLRILKDIQGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSD9</accession>
    <name>A0A074ZSD9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166173.1">
        <property type="nucleotide sequence ID" value="XM_009167909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSD9"/>
    <dbReference type="GeneID" id="20317612"/>
    <dbReference type="KEGG" id="ovi:T265_03425"/>
    <dbReference type="CTD" id="20317612"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="13873" checksum="21E56230FC7278D5" modified="2014-10-01" version="1">MFRGDSPHMLTPIALIKSLSVSFRRQLSKSPFVAGPILVATTAQIDQLSDLLTDVTLGPRVPMVYTSPSTNRVFQSISFRPSLLFSGVALLVFASVPDSLPLHFNPRRVQCFFTGFRGSLDQEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSW2</accession>
    <name>A0A074ZSW2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169751.1">
        <property type="nucleotide sequence ID" value="XM_009171487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSW2"/>
    <dbReference type="STRING" id="6198.A0A074ZSW2"/>
    <dbReference type="GeneID" id="20320449"/>
    <dbReference type="KEGG" id="ovi:T265_06267"/>
    <dbReference type="CTD" id="20320449"/>
    <dbReference type="OrthoDB" id="6284379at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008116">
        <property type="entry name" value="SSDP_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01743">
        <property type="entry name" value="SSDNABINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="766" mass="78206" checksum="BA67EA0093045DC0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG5</accession>
    <name>A0A074ZTG5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599989">
        <property type="protein sequence ID" value="KER18544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177709.1">
        <property type="nucleotide sequence ID" value="XM_009179445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG5"/>
    <dbReference type="GeneID" id="20326402"/>
    <dbReference type="KEGG" id="ovi:T265_12234"/>
    <dbReference type="CTD" id="20326402"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6523" checksum="429EAF52F04CE919" modified="2014-10-01" version="1">MYLYGTYRAEELGDLPTCGVFSVSDKPEDDGGEPVGHSCLTGVTRYVTLDHQETVREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU76</accession>
    <name>A0A074ZU76_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598156">
        <property type="protein sequence ID" value="KER18749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177504.1">
        <property type="nucleotide sequence ID" value="XM_009179240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU76"/>
    <dbReference type="GeneID" id="20330013"/>
    <dbReference type="KEGG" id="ovi:T265_15848"/>
    <dbReference type="CTD" id="20330013"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8414" checksum="9D8ED239819CE060" modified="2014-10-01" version="1" fragment="single">THSPPSLDCLPTQISSSSGARLTTKCGFAWSVGPIMYIHFSNHDPRFNRALHPANGASPSIQFHCSYVEFETWFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU89</accession>
    <name>A0A074ZU89_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598089">
        <property type="protein sequence ID" value="KER18764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177489.1">
        <property type="nucleotide sequence ID" value="XM_009179225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU89"/>
    <dbReference type="GeneID" id="20330004"/>
    <dbReference type="KEGG" id="ovi:T265_15839"/>
    <dbReference type="CTD" id="20330004"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7899" checksum="657EFE93A1FC8007" modified="2014-10-01" version="1">MNGIQGNVCRRYCELRHLGHFPTTEVDELTQRQVTLFVDRLTQALNGISWLMRVCHAKFYGVLSQHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUE5</accession>
    <name>A0A074ZUE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165211.1">
        <property type="nucleotide sequence ID" value="XM_009166947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUE5"/>
    <dbReference type="GeneID" id="20316837"/>
    <dbReference type="KEGG" id="ovi:T265_02649"/>
    <dbReference type="CTD" id="20316837"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8014" checksum="65412F44A2F2B41E" modified="2014-10-01" version="1">MVWGHHCAEEECLIGVNSDLSEIAFSSVDMRFTPFESLSPLHFTEHECVFEGTGISPSGLLIAAIESSEPVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUF1</accession>
    <name>A0A074ZUF1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597823">
        <property type="protein sequence ID" value="KER18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177429.1">
        <property type="nucleotide sequence ID" value="XM_009179165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUF1"/>
    <dbReference type="GeneID" id="20329969"/>
    <dbReference type="KEGG" id="ovi:T265_15804"/>
    <dbReference type="CTD" id="20329969"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="13021" checksum="9B1479C728739B75" modified="2014-10-01" version="1" fragment="single">MLRDTLSFYIPLQVMYRMNLFAVLLCFTMNQKYMFYYFVPLISFWFTYLSITMTLFFHVLMRKGDTGGLDIDRTKSSRSVVKLMIFALLVLAPIELLHRTPSIFGTIFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV81</accession>
    <name>A0A074ZV81_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597337">
        <property type="protein sequence ID" value="KER19094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177159.1">
        <property type="nucleotide sequence ID" value="XM_009178895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV81"/>
    <dbReference type="STRING" id="6198.A0A074ZV81"/>
    <dbReference type="GeneID" id="20326180"/>
    <dbReference type="KEGG" id="ovi:T265_12012"/>
    <dbReference type="CTD" id="20326180"/>
    <dbReference type="OrthoDB" id="5809364at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="20142" checksum="C018BE1664CBBE94" modified="2014-10-01" version="1">MIMWLHGAVLDVTCPLDFSRFPFDTQTCYLIITPWQSSMKQIQLQPMQHGPTVDNNYLPNSNVSEWKIEEIQFSLESYRSQFSVAYQYIKVSIRIKRQPLYFVIMVLVPFFMLSWLACLIFTIGDTGDRLAVALSLILSMTMYVVIVSSNAPRSMRTVPLLGESWSILCRYTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVV3</accession>
    <name>A0A074ZVV3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597249">
        <property type="protein sequence ID" value="KER19309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176946.1">
        <property type="nucleotide sequence ID" value="XM_009178682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVV3"/>
    <dbReference type="GeneID" id="20326045"/>
    <dbReference type="KEGG" id="ovi:T265_11877"/>
    <dbReference type="CTD" id="20326045"/>
    <dbReference type="OrthoDB" id="6254330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="323" mass="34812" checksum="E0B73D6B1239939B" modified="2014-10-01" version="1">MTKSDSFKVALICLQYVVHSEAAGPTVVFEPANGFVRVGTAETIKCSLQADPPKPQGTFGLVDLKTTTDLILLDNVTATIKPPTDPGTYAHVGSTTVECIFTKTDDGSTVKGTITVRVLPAKLEGTLDGGASGNPVLQVGDTKELQCDLLPAGTADKLAGTWKATLDEAGKTCAAVTVAEQKANIKPIKAGGYTEPCSFNVTCVFSATEGEQIYTFTQRVDVVGLRQDNRDTNTPTSESRYSEQWFAGNGFHISLPSHCLAAFGSPPPFTWLCEKSPSRKSVDWHTQHVTKPAQPMQCDQFIYRGIADPVSHQIRAMLRRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWE7</accession>
    <name>A0A074ZWE7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
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        <property type="protein sequence ID" value="KER19524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009178464.1"/>
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    <dbReference type="GeneID" id="20329680"/>
    <dbReference type="KEGG" id="ovi:T265_15515"/>
    <dbReference type="CTD" id="20329680"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <begin position="2099"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2133"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2158"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2208"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2278"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2292"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2337"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2350"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2456"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2508"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2531"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2544"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2568"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2595"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2620"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2645"/>
            <end position="2682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2704"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2778"/>
            <end position="2815"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2845" mass="317719" checksum="1F71F523545AA5FE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWF8</accession>
    <name>A0A074ZWF8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164437.1">
        <property type="nucleotide sequence ID" value="XM_009166173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWF8"/>
    <dbReference type="STRING" id="6198.A0A074ZWF8"/>
    <dbReference type="GeneID" id="20316213"/>
    <dbReference type="KEGG" id="ovi:T265_02025"/>
    <dbReference type="CTD" id="20316213"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1238" mass="135709" checksum="593C0BD37BDAB961" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWS9</accession>
    <name>A0A074ZWS9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597165">
        <property type="protein sequence ID" value="KER19624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176626.1">
        <property type="nucleotide sequence ID" value="XM_009178362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWS9"/>
    <dbReference type="GeneID" id="20325819"/>
    <dbReference type="KEGG" id="ovi:T265_11651"/>
    <dbReference type="CTD" id="20325819"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7655" checksum="3851C9690656531F" modified="2014-10-01" version="1">MLNAKPRVEGHTSVNHIYTTVWIDAFMCDDERLDLGVVYGAQPPEPILDRGIRKPRNWLMFKDDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX15</accession>
    <name>A0A074ZX15_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_05174</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168370.1">
        <property type="nucleotide sequence ID" value="XM_009170106.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZX15"/>
    <dbReference type="GeneID" id="20319356"/>
    <dbReference type="KEGG" id="ovi:T265_05174"/>
    <dbReference type="CTD" id="20319356"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15610">
        <property type="entry name" value="PHD3_KDM5A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
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        <source>
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        </source>
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    <sequence length="2219" mass="248700" checksum="FAC60C2403725902" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
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                <person name="Kaewkong W."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
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                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KER31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0K3</accession>
    <name>A0A075A0K3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_01175"/>
    <dbReference type="CTD" id="20315363"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13826" checksum="4CD39083A890B680" modified="2014-10-01" version="1">MRTVLEPDSDEPKIILDAQELMAKKLKGKVKGILFKYKIMIGKLKVTSQYYAVARRACGVEHLCTKLWLREVGYMHPVEQKDEKWRSKLAQSPSVQRERAISVKYACRSSIVNSSEIPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0S8</accession>
    <name>A0A075A0S8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164340.1">
        <property type="nucleotide sequence ID" value="XM_009166076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0S8"/>
    <dbReference type="GeneID" id="20316126"/>
    <dbReference type="KEGG" id="ovi:T265_01938"/>
    <dbReference type="CTD" id="20316126"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7717" checksum="EE84688DE73E2E67" modified="2014-10-01" version="1">MRRPGAAHSVAWKHHKREVQLGSRCHSNECIFANFVQFGFKQLNVLHQVASCFSPYDIRDIAIHVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Y1</accession>
    <name>A0A075A0Y1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162816.1">
        <property type="nucleotide sequence ID" value="XM_009164552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Y1"/>
    <dbReference type="GeneID" id="20314891"/>
    <dbReference type="KEGG" id="ovi:T265_00703"/>
    <dbReference type="CTD" id="20314891"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="39"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="411"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="543"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="667"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="873" mass="98260" checksum="3118E621FA4CE927" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A121</accession>
    <name>A0A075A121_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167050.1">
        <property type="nucleotide sequence ID" value="XM_009168786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A121"/>
    <dbReference type="STRING" id="6198.A0A075A121"/>
    <dbReference type="GeneID" id="20318314"/>
    <dbReference type="KEGG" id="ovi:T265_04128"/>
    <dbReference type="CTD" id="20318314"/>
    <dbReference type="OrthoDB" id="6246654at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="770" mass="87701" checksum="AF07E30C4E02495A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1G7</accession>
    <name>A0A075A1G7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596982">
        <property type="protein sequence ID" value="KER21224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175014.1">
        <property type="nucleotide sequence ID" value="XM_009176750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1G7"/>
    <dbReference type="GeneID" id="20324554"/>
    <dbReference type="KEGG" id="ovi:T265_10386"/>
    <dbReference type="CTD" id="20324554"/>
    <dbReference type="OrthoDB" id="10390323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="275" mass="30781" checksum="4A5B6F215C9AFEB7" modified="2014-10-01" version="1">MHWRSTELLSGRMVRSAGALTYCVEVHQVGNVALTRDNFNSLKPALAKQLQSQVEARVHPAPMPRLRGNKKSFNCSTLSVPSCHATHEGGTRAGILPGCPGLNRGSREGEVGFEPRTTRKQVGTIGHRCREAIVHLYFSLSLLSSNLKCAARQTTRIVNVIPRRVLDFEDRLAVSAITHFHTRFHPADTGFPEQWKIGLQGVIDSLGVNKGLGINFQLPVYGEFSKRYEICAYFDNIASMVACFRIFHWRIADLQWFRILRNASSSPVITFPKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Y0</accession>
    <name>A0A075A1Y0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596969">
        <property type="protein sequence ID" value="KER21414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174840.1">
        <property type="nucleotide sequence ID" value="XM_009176576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Y0"/>
    <dbReference type="GeneID" id="20324425"/>
    <dbReference type="KEGG" id="ovi:T265_10257"/>
    <dbReference type="CTD" id="20324425"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9515" checksum="24DBA479546DD193" modified="2014-10-01" version="1">MHILQSCLMRDQLQTEPSTLFRKRKIRIIWCLRTSIQERLVGLTCEECGKCCKSKGVLVTHFRVHVHKNVCTNMVAQSTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2P8</accession>
    <name>A0A075A2P8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162585.1">
        <property type="nucleotide sequence ID" value="XM_009164321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2P8"/>
    <dbReference type="GeneID" id="20314705"/>
    <dbReference type="KEGG" id="ovi:T265_00517"/>
    <dbReference type="CTD" id="20314705"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12622" checksum="989CA8BA2C87B5A2" modified="2014-10-01" version="1">MQLGTGRVLQPNDYIFLFYQLTVDVHFLAPHCSAVGFVIIIIIDSMTSVFNTDVSLPYNHDLFESFIVKNKAEYAAHRPSHDSVGTIFEISQYIFIRETTHKVAENVPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A338</accession>
    <name>A0A075A338_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161924.1">
        <property type="nucleotide sequence ID" value="XM_009163660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A338"/>
    <dbReference type="GeneID" id="20314191"/>
    <dbReference type="KEGG" id="ovi:T265_00003"/>
    <dbReference type="CTD" id="20314191"/>
    <dbReference type="OrthoDB" id="6223623at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23197" checksum="61EBEC7B78504436" modified="2014-10-01" version="1">MSTVSELVENFCWKSKTRSVWKDEPDLLDNAMARIHSEAAVTDAILRSKNTTVPSLEKISKTVKFLEQNSFWRSNPFSLVSGAEDDPAVARATRRLQMKCIRDLWESSACRGITSDDSSVAFVQRQAESSTEIRDFEASKPKVPRTAELTTVEAVFRESSSRYMPALSPKSVNSREKIVTNSSPVICDRNEALQTYAEAEQYHSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3J2</accession>
    <name>A0A075A3J2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166118.1">
        <property type="nucleotide sequence ID" value="XM_009167854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3J2"/>
    <dbReference type="STRING" id="6198.A0A075A3J2"/>
    <dbReference type="GeneID" id="20317572"/>
    <dbReference type="KEGG" id="ovi:T265_03385"/>
    <dbReference type="CTD" id="20317572"/>
    <dbReference type="OrthoDB" id="6126662at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="303" mass="34458" checksum="A8102A8C1CCCE4CA" modified="2014-10-01" version="1">MWFNDEERSTRLDRSAGCFTNQETSTFGIPPNPSPTSFDPSVPPISITNRFQRTHTRHSIYSSQHSSADFSTPNLSHKDPLFREVLQLQREILYPGGIITEGVPSDFRRYVAFVNAGHRVWVAGWNNACKELYRLFHIGDQLVSINNLLVKDSRHAFHLFCHIESERENWCTLRLRRTPLAKSFAVRRVEPGQSVGVRLNQGTNEVRLVVPDGLVSKVGLSSAPELSLATCSLEKKQMDKSSQTWTITELNGHAVNMFFTHGETEVLLNAYGSEMSFVVQPSDLIACLRQELKRFKSYKQYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5S5</accession>
    <name>A0A075A5S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596880">
        <property type="protein sequence ID" value="KER22779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173461.1">
        <property type="nucleotide sequence ID" value="XM_009175197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5S5"/>
    <dbReference type="GeneID" id="20323364"/>
    <dbReference type="KEGG" id="ovi:T265_09185"/>
    <dbReference type="CTD" id="20323364"/>
    <dbReference type="OrthoDB" id="5860246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11719" checksum="BE20C90403AC24E4" modified="2014-10-01" version="1">MLPEARGLGYCHVAQGKSIGRGRVRTTDLPVAPFRCLTAMPAEGSRRDGILPGYPNLDRGSRVAEVGFEQQTFGSTLEINLQEPMPSQHMCFFYSHPEAIKTSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A604</accession>
    <name>A0A075A604_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162518.1">
        <property type="nucleotide sequence ID" value="XM_009164254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A604"/>
    <dbReference type="GeneID" id="20326698"/>
    <dbReference type="KEGG" id="ovi:T265_12530"/>
    <dbReference type="CTD" id="20326698"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="415" mass="48086" checksum="CE19BBFE639CDF34" modified="2014-10-01" version="1">MHVSEANAKKCRWFYCGTALLILLYIAFLYLIKYSNYRTRLFRQEITLIDSESELQDMGDRRSYRLGSIVEYVGTTPVWRVSSVEQLYKRMSWTSMQLTLFVLLTGNSFARKQEPENSEHMLKAVLFDCQPMAPRMLDKIKIPVFLYKNCFRSVSQFMTLGSIPDRVANPTNIEVPFNVRNPIYNLSRVYLLPLNKTSLSRPCPIVSASRRESLYRTLQDWIRIANQSKILWWITYGTLLGSWRDGNMIPYDSDVDISILGSYEKRLRELATDRKSIQKGKFNLVTRPGEHCVTSPGLRLDCGGRNVTSLRDTCSFCGPLARMFRQYGEYIDIYPVHLEVRMDVANNPIEFGYLDEGMDRDRVEPASVIFPLRNCKYMGLNVPCPNDPERFLTSVYGKEFALPKSRCSQETGRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6K8</accession>
    <name>A0A075A6K8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165014.1">
        <property type="nucleotide sequence ID" value="XM_009166750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6K8"/>
    <dbReference type="STRING" id="6198.A0A075A6K8"/>
    <dbReference type="GeneID" id="20327184"/>
    <dbReference type="KEGG" id="ovi:T265_13016"/>
    <dbReference type="CTD" id="20327184"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43931" checksum="EFFA381BF97C0383" modified="2014-10-01" version="1" fragment="single">LVTDLHNPSVQIVADENLVDLEYTDDLLIFEDEGKARALWNKLTAILPSFSVRPAPSKCNVRLQNIQSLNLPLTVQAEEVEVVENCAYLGNCVSSDESMSDQTLFTFILLRLFFVSDIQKRERLQVIRTVFPLSFCYAVDITMGIAGTGTLSQLNHFKNLSVCRTVRPLSVYVTVGLMVLGAAVAALTVRPLSVYITVGLMVLGAAVAALGDITFDPLGYTFVFINNFSTAGKALLSKSRLRDKGYSSIELLYYNSAFMIPFLLVVTALTSNVFQIINFSFWTNPIFILYFIFSCCSAVLLNYSMLQCTHYTSALTASIVGVIKNIIVTYAGMFIGGDYVFTPTNFTGVTIRQVNAVASAMYVAATYRKQPQESGVEVAARKMESTVLSVPAVQDKEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A767</accession>
    <name>A0A075A767_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_02282</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164750.1">
        <property type="nucleotide sequence ID" value="XM_009166486.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A767"/>
    <dbReference type="GeneID" id="20316470"/>
    <dbReference type="KEGG" id="ovi:T265_02282"/>
    <dbReference type="CTD" id="20316470"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14337">
        <property type="entry name" value="UBA_MARK_Par1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="228"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="1644"/>
            <end position="1693"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="546"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="773"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1212"/>
            <end position="1347"/>
        </location>
    </feature>
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        <location>
            <begin position="1413"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
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        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="876"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="965"/>
            <end position="978"/>
        </location>
    </feature>
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        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
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        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
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        <location>
            <begin position="1023"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1108"/>
        </location>
    </feature>
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        <location>
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            <end position="1290"/>
        </location>
    </feature>
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        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
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        <location>
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            <end position="1484"/>
        </location>
    </feature>
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        <location>
            <begin position="1525"/>
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        </location>
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        <location>
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            <end position="1564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER31510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1693" mass="183471" checksum="CAECB3C4B7B5CB10" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAD0</accession>
    <name>A0A075AAD0_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">T265_01197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_01197"/>
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    <dbReference type="OrthoDB" id="6764824at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9791" checksum="C2D4C419B649AF83" modified="2014-10-01" version="1">MNNKQKGARYEWFKLSALPNLYADVLLGNDFLGLHGKVEIPFNGERTTLTVFDVTIAKLESPFLSANLAAHRKPIAPKSRRQIPEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADT0</accession>
    <name>A0A075ADT0_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19828" checksum="8C5940C04E22BE91" modified="2014-10-01" version="1">MSSFQADVHPSPDPDKVVDSLCDLVRITTRIVLLASSSSHKRRMSTSSARDPYVCTFDKDTCGWSNDPNNWKYLWSLTLVTGTSQVPHRALCLSASATGVRGAVSQGLTPWGRVIETREHKPDLDSELSQVRLWSPYVTQDDNLECLKLLYRIESGSLKSSSSMHPTGPSLALLKRHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEB4</accession>
    <name>A0A075AEB4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169643.1">
        <property type="nucleotide sequence ID" value="XM_009171379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEB4"/>
    <dbReference type="STRING" id="6198.A0A075AEB4"/>
    <dbReference type="GeneID" id="20320360"/>
    <dbReference type="KEGG" id="ovi:T265_06178"/>
    <dbReference type="CTD" id="20320360"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="726" mass="81977" checksum="63AB9DD07921153E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEJ1</accession>
    <name>A0A075AEJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169486.1">
        <property type="nucleotide sequence ID" value="XM_009171222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEJ1"/>
    <dbReference type="GeneID" id="20320234"/>
    <dbReference type="KEGG" id="ovi:T265_06052"/>
    <dbReference type="CTD" id="20320234"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9985" checksum="E938C6BF66A97F59" modified="2014-10-01" version="1">MQDKNVDQKTLWFYLQPGACEFVHLTRVAALNVTVQQRERAAQNLPLQVSFDRIDQSSVPSSSLDAGFTQYADLEEIWNASAQSTLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AET2</accession>
    <name>A0A075AET2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169249.1">
        <property type="nucleotide sequence ID" value="XM_009170985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AET2"/>
    <dbReference type="GeneID" id="20320046"/>
    <dbReference type="KEGG" id="ovi:T265_05864"/>
    <dbReference type="CTD" id="20320046"/>
    <dbReference type="OrthoDB" id="15743at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029027">
        <property type="entry name" value="Single_a-helix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015089">
        <property type="entry name" value="UQCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08997">
        <property type="entry name" value="UCR_6-4kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81518">
        <property type="entry name" value="Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7756" checksum="DD9ED665D0B48131" modified="2014-10-01" version="1">MAFDVDKAQLLRSVSRVIVPVQNFAAAWGKPIAVWSAGAGVLALYFVDWKVIFARIPGYKRKFDEDTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFG9</accession>
    <name>A0A075AFG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168517.1">
        <property type="nucleotide sequence ID" value="XM_009170253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFG9"/>
    <dbReference type="GeneID" id="20319460"/>
    <dbReference type="KEGG" id="ovi:T265_05278"/>
    <dbReference type="CTD" id="20319460"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10463" checksum="F7E64F76CB27D169" modified="2014-10-01" version="1">MEVTGYEDEKLVTTAAYVDEEDARYGSISVRLAEDDSLIEETIFCLVVTSTAQKSPDGGFLDEEPFNRRSFITGQSGKHGQGISGSEGQRKRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGG8</accession>
    <name>A0A075AGG8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167511.1">
        <property type="nucleotide sequence ID" value="XM_009169247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGG8"/>
    <dbReference type="GeneID" id="20318674"/>
    <dbReference type="KEGG" id="ovi:T265_04492"/>
    <dbReference type="CTD" id="20318674"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12161" checksum="58C9DA3E0A7FBCC8" modified="2014-10-01" version="1">MSALRKAADLIDDAPEYELTLIRKLLNRRTIVRIQTLYIRRTGTIISHLAESSSAEFGNILIDAQLNQYKRSFAARQPELTVQQALVFYWLQVSRMEQRLTQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHK6</accession>
    <name>A0A075AHK6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium activated potassium channel subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166171.1">
        <property type="nucleotide sequence ID" value="XM_009167907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHK6"/>
    <dbReference type="GeneID" id="20317610"/>
    <dbReference type="KEGG" id="ovi:T265_03423"/>
    <dbReference type="CTD" id="20317610"/>
    <dbReference type="OrthoDB" id="6224119at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015269">
        <property type="term" value="F:calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005513">
        <property type="term" value="P:detection of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003930">
        <property type="entry name" value="K_chnl_Ca-activ_BK_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258:SF8">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL BK ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10258">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40569" checksum="B174C7570C5BA632" modified="2014-10-01" version="1">MLQATASLIAEARGEEQGRLLPYMGTKREGSSVASYPSKRDYQRRIGFSVTVRLRNRVCSDSCLKFVYLSCATLVSASFIIECILLHLIVVPYLSESVFEPGICKYNGSRRDDSPKKCENKCSKERSSFPCLQIRVVFTPLHVDPNQSHHNQTGDTDDRELSATLDSVIRNQLDSPFASHWIPQQNEDIPVNARYNFSSPESRVLYLFDYFSTFAAHKASRCSTSPCHRREEDNKDAVEDFKRVLWRQHIFLCYARPRKAPHSTEPHNQVAGINQPGLVTTTTSTILDLEETTQSPVWQRRDPKDAAAIIYRLYTPTMFFHSLCWPGGIFLSALVILLFTYLADGCQAWARDKTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJF0</accession>
    <name>A0A075AJF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162912.1">
        <property type="nucleotide sequence ID" value="XM_009164648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJF0"/>
    <dbReference type="GeneID" id="20314964"/>
    <dbReference type="KEGG" id="ovi:T265_00776"/>
    <dbReference type="CTD" id="20314964"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9716" checksum="242F0CC53634EC57" modified="2014-10-01" version="1" fragment="single">CHIGHRVVPSAGSPYLLHTAGRAQHLGLMTPFVMHRFCVQHLLVTWCRHLQESPNQSSSLDTHSIWPRSMRNFLILFARQTSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJI9</accession>
    <name>A0A075AJI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162675.1">
        <property type="nucleotide sequence ID" value="XM_009164411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJI9"/>
    <dbReference type="GeneID" id="20314771"/>
    <dbReference type="KEGG" id="ovi:T265_00583"/>
    <dbReference type="CTD" id="20314771"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="242" mass="27676" checksum="8C22FB86819E23AE" modified="2014-10-01" version="1">MWLVQNSLDLVRRVLLMIPNKDKTAVQCFSDFPPRLKSFSCSTFWVPYCHATEGSTRVGILPGCPSLDRGSREAEVGFEPRTFRPVNSRSNHLNHLAPIWPHFSCTHTHTHTSLLITPNISRRSPRVSINLLFYLNPNWTVFEKYTQLRISSVFTPPHVSVDTIFEISHYIFIKETTHKAVEEFSATLHIGPSVGHTAKPLGRVRVQFARKLGSYAVNAIMVMREPHCLRDWANSVNVINQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJW3</accession>
    <name>A0A075AJW3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162289.1">
        <property type="nucleotide sequence ID" value="XM_009164025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJW3"/>
    <dbReference type="STRING" id="6198.A0A075AJW3"/>
    <dbReference type="GeneID" id="20326669"/>
    <dbReference type="KEGG" id="ovi:T265_12501"/>
    <dbReference type="CTD" id="20326669"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="368" mass="40955" checksum="20FF1295DE6C28C1" modified="2014-10-01" version="1" fragment="single">ERQPLNDKNIIEILGRRPVYQSVKQGHSCDDKPITGLSFLPSTAREIRVHCLLAATMKSTRPVFSVVKAVILGPPGSGKGTISKRITKDFPLDCISSGDLLRAHVADNSMIGVAASKYMSKGQLVPDDLVTKMMLQECARYRDSNLLLDGFPRTVEQAKALDKETTINCVINLDVPFDEIINRVKCRWVHLPSGRIYNTEFNPPKIPGLDDITGEPLVQREDDQPETVRARLETYGRVMKPLFDYYKYLQINLRHPVHQAAFNVRTLKQAGQRTALALTLDSLGFDVCSSQKRGFKMQALFGLTAPSVSTPFWLRNSDNPEAAVAECTEIGIVLSHRAELSLFDCIPVDSRICADRLVHLTSGKLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YT82</accession>
    <name>A0A074YT82_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_12402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL620220">
        <property type="protein sequence ID" value="KER18006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178247.1">
        <property type="nucleotide sequence ID" value="XM_009179983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YT82"/>
    <dbReference type="STRING" id="6198.A0A074YT82"/>
    <dbReference type="GeneID" id="20326570"/>
    <dbReference type="KEGG" id="ovi:T265_12402"/>
    <dbReference type="CTD" id="20326570"/>
    <dbReference type="OrthoDB" id="6256412at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000045">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7138" checksum="FAFFEE096BBC3BFC" modified="2014-10-01" version="1">MNSFVNDIFERIAAESSRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUH6</accession>
    <name>A0A074YUH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL602494">
        <property type="protein sequence ID" value="KER18358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177895.1">
        <property type="nucleotide sequence ID" value="XM_009179631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUH6"/>
    <dbReference type="STRING" id="6198.A0A074YUH6"/>
    <dbReference type="GeneID" id="20330278"/>
    <dbReference type="KEGG" id="ovi:T265_16113"/>
    <dbReference type="CTD" id="20330278"/>
    <dbReference type="OrthoDB" id="332250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8334" checksum="CD2116DD9383F86B" modified="2014-10-01" version="1" fragment="single">PNSKSTTQRYAGVAELVSIRSVSENDLSGSGVQSDRIVGQLVYSLLLEDHGPHLMMKDTETEHKQVMVSESEMGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVE7</accession>
    <name>A0A074YVE7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12163</name>
        <name evidence="1" type="ORF">T265_12175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598261">
        <property type="protein sequence ID" value="KER18736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL598070">
        <property type="protein sequence ID" value="KER18769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177484.1">
        <property type="nucleotide sequence ID" value="XM_009179220.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177517.1">
        <property type="nucleotide sequence ID" value="XM_009179253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVE7"/>
    <dbReference type="GeneID" id="20326331"/>
    <dbReference type="GeneID" id="20326343"/>
    <dbReference type="KEGG" id="ovi:T265_12163"/>
    <dbReference type="KEGG" id="ovi:T265_12175"/>
    <dbReference type="CTD" id="20326331"/>
    <dbReference type="CTD" id="20326343"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="38" mass="4312" checksum="3A12D41A5792AFF0" modified="2014-10-01" version="1" fragment="single">VLLHFASANVYTHYLVESQDLYKTDQLAGKLLPCLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWZ2</accession>
    <name>A0A074YWZ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597244">
        <property type="protein sequence ID" value="KER19326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176932.1">
        <property type="nucleotide sequence ID" value="XM_009178668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWZ2"/>
    <dbReference type="GeneID" id="20326037"/>
    <dbReference type="KEGG" id="ovi:T265_11869"/>
    <dbReference type="CTD" id="20326037"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13528" checksum="D0A9AE70FA1A2EAC" modified="2014-10-01" version="1">MPTDTVAIGGNTKEQHDLNQRSFSKATRNIAQWVAEVHKPPHHGRVQPLRDGITINDNKTVTASKAICLLGYEFSKGVISPTLNARSVIASYLLRILPWKCSASSVCSYTMPIGYLRFLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYZ1</accession>
    <name>A0A074YYZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601530">
        <property type="protein sequence ID" value="KER18422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177831.1">
        <property type="nucleotide sequence ID" value="XM_009179567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYZ1"/>
    <dbReference type="STRING" id="6198.A0A074YYZ1"/>
    <dbReference type="GeneID" id="20326447"/>
    <dbReference type="KEGG" id="ovi:T265_12279"/>
    <dbReference type="CTD" id="20326447"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7695" checksum="08B572D9A164A4BA" modified="2014-10-01" version="1" fragment="single">CLPAFRNNTLRRACWDTYGSDPTLLCPLVTPANCLRSPLIPLILATSLPDTADWMWRTTLLQLPIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZB2</accession>
    <name>A0A074YZB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597105">
        <property type="protein sequence ID" value="KER20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176244.1">
        <property type="nucleotide sequence ID" value="XM_009177980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZB2"/>
    <dbReference type="STRING" id="6198.A0A074YZB2"/>
    <dbReference type="GeneID" id="20325517"/>
    <dbReference type="KEGG" id="ovi:T265_11349"/>
    <dbReference type="CTD" id="20325517"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16196">
        <property type="entry name" value="EFh_PEF_CalpA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735:SF3">
        <property type="entry name" value="CALPAIN SMALL SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46735">
        <property type="entry name" value="CALPAIN, SMALL SUBUNIT 1 A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="25544" checksum="6367E41BF97E9CFA" modified="2014-10-01" version="1">MSSNKSGTRVQCFAPLVSELAALGRLMFQSLRYSGYRDICTFPQEPKTEDDVSLVEKLRAAFTDVAGPDGVLSYPELRDILNAAFIKEFAFEGFSRETARSMVALMDTDLSGSLDFMQFKKLWMDLRLWKSIFKRFDRNGNGTMDAFELRDLLRAVGISVSNRVYHAIVCRYANRKGEIFFDDYVLLLVRLSTVIETFKAQKRLDDGRAAFDIEEFTRSVIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1M9</accession>
    <name>A0A074Z1M9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597224">
        <property type="protein sequence ID" value="KER19392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176860.1">
        <property type="nucleotide sequence ID" value="XM_009178596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1M9"/>
    <dbReference type="GeneID" id="20329720"/>
    <dbReference type="KEGG" id="ovi:T265_15555"/>
    <dbReference type="CTD" id="20329720"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21212" checksum="5E9402EB52718660" modified="2014-10-01" version="1" fragment="single">MPCQPRMVSIIGWRSMIGVTRNVQLDKIYKCESCGRSIEDISPGPNGPMHFSDETTRKNFNSQNPLAIQHATLRFTLIVSQMVQILLSEMQGPGNHSLLDSLRSKGPVDTGSFSCCFRKKRHAVRMSGQCNPRGERGSKTANKVRVAAIPIEPQRASSITRLGMIYLPVAYNFMMKITVTAYGKVDETKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2T0</accession>
    <name>A0A074Z2T0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="KL597133">
        <property type="protein sequence ID" value="KER19822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176437.1">
        <property type="nucleotide sequence ID" value="XM_009178173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2T0"/>
    <dbReference type="STRING" id="6198.A0A074Z2T0"/>
    <dbReference type="GeneID" id="20325671"/>
    <dbReference type="KEGG" id="ovi:T265_11503"/>
    <dbReference type="CTD" id="20325671"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000101">
        <property type="entry name" value="N-alpha-acetyltransferase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21667" checksum="0E6EF42A9D6D05F1" modified="2014-10-01" version="1">MNIRNARPTDLLNMRDCNLDCLPENYQMKYYFYHGLSWPQLSYVAETDDGEIVGYVLAKMEEDPEDVPYGHITSLAVKRPYRRLGIAQSLMNFASRAMVENFHARYVSLHVRKSNRAALTLYKKTLHFVVADVEPKYYADGEDAYAMKRDLRCIWEKVQFLFLSTSLFQYGPPGVPFKETKNKLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3A6</accession>
    <name>A0A074Z3A6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174772.1">
        <property type="nucleotide sequence ID" value="XM_009176508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3A6"/>
    <dbReference type="STRING" id="6198.A0A074Z3A6"/>
    <dbReference type="GeneID" id="20329248"/>
    <dbReference type="KEGG" id="ovi:T265_15082"/>
    <dbReference type="CTD" id="20329248"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="332" mass="38382" checksum="7DF13130929BBC65" modified="2014-10-01" version="1" fragment="single">KTTHKVVENSSTAHDRFRPSAWGSSGRRRPRVSVNLMFYLNPNWTTFKKYSRLQINLAQPLRFPSVTFMFRFNSICTTFDKYTQLRTNRVRTGDSVECLVCDVLQRNVMHKGHLSRDSHWPCDHTDILRKRVKAGSANGTRTSMATGCAAPGRLMFQWLRYSIHRSKGVFCNALLVRLLKIRRQPTTGFALLGTHQATECAAPGSLIFQSLRYLKYRDTYMCNTSIFVSRYLENHTKGNMRRPGAAHSVAWGHHKREIQLIQLNLSFMIFCNLMGCTQAAPCFSWHDIQDITIYFHKGNYPQAAESSAPGRLMFQSLRYLRYHETCIFVMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3E4</accession>
    <name>A0A074Z3E4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596959">
        <property type="protein sequence ID" value="KER21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174715.1">
        <property type="nucleotide sequence ID" value="XM_009176451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3E4"/>
    <dbReference type="GeneID" id="20324329"/>
    <dbReference type="KEGG" id="ovi:T265_10161"/>
    <dbReference type="CTD" id="20324329"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="319" mass="36504" checksum="7CD1C118241B81B6" modified="2014-10-01" version="1">MNVDHALIDLWVSMWRIRLVSGTEPRLRFRMKYGVTKNHKLNGHPAYENAYESGSRCGVNRSPRSVKQMCKMTRKNGGLQNPKTKRNSQTERSRPCTEWVWKNSLRVRAVRNEHQDDDPESHSAVESEVVAVRTIGAFGPLQRVTPSATNVAQGQWKTRRQNQPGLEAAQYIELPKRIRFILQTSTVLSEWEIVSGGSTDRHNGDGHWVIVRAIRWNKYINEARIWCYLTGKLLQAPVSERAKDQTGTITFDERKHFDCWTKDFEQQFLWPSVAIQLDSRTALEIRVVKLETLAAPEVYACIHAHERHGAAGPDASNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3I6</accession>
    <name>A0A074Z3I6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596954">
        <property type="protein sequence ID" value="KER21611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174642.1">
        <property type="nucleotide sequence ID" value="XM_009176378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3I6"/>
    <dbReference type="STRING" id="6198.A0A074Z3I6"/>
    <dbReference type="GeneID" id="20324274"/>
    <dbReference type="KEGG" id="ovi:T265_10106"/>
    <dbReference type="CTD" id="20324274"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="315" mass="35703" checksum="72304A20B9F8CBA5" modified="2014-10-01" version="1">MTSDNNVLHQGEPLWKIGDTVNPIQLDFNVPDYVTQRNDAESASWKLCPPTKYCDNSECNSDLEAITSKTVSEASQLPDPTSVIPDVERMRRDIANGWTLPSVAFKYAVPSASCCYEPCCEDVQAQDVIPNNRKKRRPYTRFQTLALENEYIETSYITRQKRLEISSRLHLSERQVKVWFQNRRMKSKKLESRAKAGIIDIYNKDLEIDAPTATELPRPPEKTEILENVNESHINNDRTDGSATTNFPNFPGCPFKFSAAGLSQSIYKPTNYFYGDTWFLPANTASPLSNENENGFAYGSRGKPQFPSGQTEEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6F9</accession>
    <name>A0A074Z6F9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CRESS-DNA virus Rep endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_12138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597804">
        <property type="protein sequence ID" value="KER18830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177422.1">
        <property type="nucleotide sequence ID" value="XM_009179158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6F9"/>
    <dbReference type="GeneID" id="20326306"/>
    <dbReference type="KEGG" id="ovi:T265_12138"/>
    <dbReference type="CTD" id="20326306"/>
    <dbReference type="OrthoDB" id="1732219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049912">
        <property type="entry name" value="CRESS_DNA_REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02407">
        <property type="entry name" value="Viral_Rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52020">
        <property type="entry name" value="CRESS_DNA_REP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRESS-DNA virus Rep endonuclease" evidence="12">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER18830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="30091" checksum="E626AC0B7FDBB7C2" modified="2014-10-01" version="1">MAGRAPKGRNFIVTYNNPTETANELVQRSVANNLRYAIQRGRGTEAGTEHYQIYLNYPTTKTCSQVRRILPHGHVEIARNPIAARRYCIKSDTRIDGPWTNIESREETMAQEKKPNYMQELIDRYKQGTSIQQLAEEYPNLFARNYNNIMRTLDLICHSTPRSTKTEVWWLYGKTGTGKSSKALQMAEAKPTYWKNSTEWWDPLDLATLLQEALKRRFGGYTGRQEQENQARPYKWRRLSLHTGRTQPNGGTTTNNKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Z6</accession>
    <name>A0A074Z6Z6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597389">
        <property type="protein sequence ID" value="KER19005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177249.1">
        <property type="nucleotide sequence ID" value="XM_009178985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Z6"/>
    <dbReference type="GeneID" id="20329871"/>
    <dbReference type="KEGG" id="ovi:T265_15706"/>
    <dbReference type="CTD" id="20329871"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7489" checksum="8F15609FBA4C5B15" modified="2014-10-01" version="1" fragment="single">MIRGSSAFYKKQDAHIHELEKLTGLENIEDESTTEEPIPNNPDKVHFRGQVSNMVIMRVVFFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7M4</accession>
    <name>A0A074Z7M4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597290">
        <property type="protein sequence ID" value="KER19210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177046.1">
        <property type="nucleotide sequence ID" value="XM_009178782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7M4"/>
    <dbReference type="STRING" id="6198.A0A074Z7M4"/>
    <dbReference type="GeneID" id="20326107"/>
    <dbReference type="KEGG" id="ovi:T265_11939"/>
    <dbReference type="CTD" id="20326107"/>
    <dbReference type="OrthoDB" id="6253503at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227">
        <property type="entry name" value="BUCENTAUR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23227:SF67">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="269" mass="30343" checksum="173EA9ED9DB723A4" modified="2014-10-01" version="1">MNSALSHFSLRVSGDPEAMTRGIYGVGVALSPRAERVLLDWIPVNSRLCAVRLSSSIKLNASRHKKRCLFVVSAYAPTDCSSDAEKDTFYRELSRLIRQAKSTDIVILAGDLNAQVGRLSSLESHLGGRFGVDARRTDNGDRLLQLCADHELFLASTNFQHKRSHRVTWRPPTTNQPWTQLEHVAISHRWRATIQDCRSFWDTPLDSDHTVVRARLILRFPSGHCKSARSMPIHQLRRTAIAQQYRSELAQQLSTVKQYCGGSEHVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z883</accession>
    <name>A0A074Z883_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KER23318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DBC1/CARP1_inactive_NUDIX"/>
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    </dbReference>
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        <location>
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            <end position="548"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116829" checksum="10F22F565D65B8A8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9C8</accession>
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        <name evidence="1" type="ORF">T265_11468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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    <reference evidence="1 2" key="1">
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            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="KER19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="14038" checksum="685EE18B69C99DEC" modified="2014-10-01" version="1">MLLSLLARLWAFRRHQSSAKMFTSSYVRIQTQPACAELISSAYPMVMPGFESETSDIRGERVTTTPPTQIPRFKSRHGHWITVLNNYARKGGRLLKRESKQVWGAFTDVLDLNTKWFFAKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="STRING" id="6198.A0A074ZAK1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="306" mass="35333" checksum="A0EEE4EBE86F05DF" modified="2014-10-01" version="1">MVEEEESVRVKNYLAKLRDPVTNRFHSVTAREFLECWQHYDKDGNGYLEGAELDGFLREFISSVIPGDIGDEVVSEIALAQLKSEFMEAYDDNGDGRIDINELAQILPTDETFLALFQHEAPLSSSVEFMRVWRQFDEDNSGYIEQNELRGFLKHLLARSNVEITDEKLDDYTNTFLILFDRDGDGRLQLSEMARLLPVKENYLVKPLFKNTKGIDERTVDRIFRKYDTDGNGILEDEELLGFLKDLLEAGGGEFTEKRMEEMKNSILSQWDVNHDGKIGKEELTDLILHTVRITQEAEALTRYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAL7</accession>
    <name>A0A074ZAL7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175993.1">
        <property type="nucleotide sequence ID" value="XM_009177729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAL7"/>
    <dbReference type="GeneID" id="20325315"/>
    <dbReference type="KEGG" id="ovi:T265_11147"/>
    <dbReference type="CTD" id="20325315"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000002">
        <property type="entry name" value="WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703915" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10487" checksum="97D01B10E707141B" modified="2014-10-01" version="1">MAHSMFTSLLSVMILECALQYTEAWKWNRKVPALFQPIEFCNLPPSVGMCRAMIPRFAFNPQTGECELFYYGGCGGNGNNFESREDCMATCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBD5</accession>
    <name>A0A074ZBD5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KL596809">
        <property type="protein sequence ID" value="KER24438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171784.1">
        <property type="nucleotide sequence ID" value="XM_009173520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBD5"/>
    <dbReference type="STRING" id="6198.A0A074ZBD5"/>
    <dbReference type="GeneID" id="20322049"/>
    <dbReference type="KEGG" id="ovi:T265_07870"/>
    <dbReference type="CTD" id="20322049"/>
    <dbReference type="OrthoDB" id="6427080at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123622" checksum="F5CA23804A91BCD8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBF8</accession>
    <name>A0A074ZBF8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173347.1">
        <property type="nucleotide sequence ID" value="XM_009175083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBF8"/>
    <dbReference type="STRING" id="6198.A0A074ZBF8"/>
    <dbReference type="GeneID" id="20328921"/>
    <dbReference type="KEGG" id="ovi:T265_14755"/>
    <dbReference type="CTD" id="20328921"/>
    <dbReference type="OrthoDB" id="10065050at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="407"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="602" mass="65926" checksum="B53B642F84012F87" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCT8</accession>
    <name>A0A074ZCT8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172802.1">
        <property type="nucleotide sequence ID" value="XM_009174538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCT8"/>
    <dbReference type="GeneID" id="20322846"/>
    <dbReference type="KEGG" id="ovi:T265_08667"/>
    <dbReference type="CTD" id="20322846"/>
    <dbReference type="OrthoDB" id="10022495at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="31446" checksum="4582475715D779BA" modified="2014-10-01" version="1">MEGIFVFSFPEQERNRSRKPIPIAAKAIEYFDKQEPVEEVTTPVFRNDVPDRTKSAKDKRSFALAPYQRKNTERRLKSAVLCITGFSTTDRETSRIDSSTPVSSTTSTISQFQDTARPLSSSVHRAESLFEKPVWEHPALKEIKEDDYLEIGCAEESITTMNPLVKSKDSYEKALKVYGWRMEVPRDPLYLKKPYLPKRRSYSVDISLEPSLPLPPKMRVSKAETFFQPTVKIMPLSFTVSPDFSSEAFVAKQNDLRRSGNWNYGTRRYAFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEC3</accession>
    <name>A0A074ZEC3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170637.1">
        <property type="nucleotide sequence ID" value="XM_009172373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEC3"/>
    <dbReference type="GeneID" id="20321146"/>
    <dbReference type="KEGG" id="ovi:T265_06967"/>
    <dbReference type="CTD" id="20321146"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11346" checksum="1144E15F61746ABF" modified="2014-10-01" version="1">MSPRLVMKRLQSNCPAQRTSQRPPSDSLIPELFRKAVGRMPLELVEPVEKMLSRSSQRRPTSQLFALVSFEKILTLKVSYVVIFYEHLLPKYLSGTPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEU6</accession>
    <name>A0A074ZEU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170442.1">
        <property type="nucleotide sequence ID" value="XM_009172178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEU6"/>
    <dbReference type="GeneID" id="20328303"/>
    <dbReference type="KEGG" id="ovi:T265_14137"/>
    <dbReference type="CTD" id="20328303"/>
    <dbReference type="OrthoDB" id="6236618at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704083" evidence="1">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="43124" checksum="54916FEC2A49F7DB" modified="2014-10-01" version="1" fragment="single">MWSFSTFVIFMYFCCGSYSLPDKGCCIRGRQICSSLKISVAGFNKACETVIPSVKTLAENGFYVEQNQSLPRGYYAILAWAPNSLPKPERFRQILFTYAAMNIHDSCFKKPEPCRPQQINSFEPDCSEQNEVFRLFDIFLLPQTSWIMGNSVRLMVSNTFDYKNFYNRTLFRRSPDRCNRFVLHACRRPPEYDKLLHQHQLRDSLGLPVDPQARPSTLDSIFQEHFPGIVVSNSMLEYEEETCFLSAELQNQAIDKEESLYMSPSSCTDPFIEAVSPIEYAFNLTIIANKWFIYAQQEYVHYQVLKKYVSDLKMLHGFEENHIVIQRGRDNKRRMGRIVARLQLIFDKLIARHVRWAPPFLYLRNTPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF95</accession>
    <name>A0A074ZF95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596764">
        <property type="protein sequence ID" value="KER25858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170388.1">
        <property type="nucleotide sequence ID" value="XM_009172124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF95"/>
    <dbReference type="STRING" id="6198.A0A074ZF95"/>
    <dbReference type="GeneID" id="20320950"/>
    <dbReference type="KEGG" id="ovi:T265_06771"/>
    <dbReference type="CTD" id="20320950"/>
    <dbReference type="OrthoDB" id="6431598at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF2">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="373" mass="43752" checksum="4A7B4A0C003208FF" modified="2014-10-01" version="1">MRRKLEGLQNPGVQIASEENLVDLEYTDDIVLMFEEEEKAQVFLDELTAKTQATSEEQNMAKCEEPVEEVESEEQIAMAKEAEKLEQQQKRLKFLQDQLEELNQRENEADHLVEEENQLTRILARLDKLELQLRALEDKYKQGFSRRAPLRQHNATLRRRSTAIQSELKSQLEWLERFVSQCTQGENSEDKANSEGVEAVRKIVEADLEKEKKFVLELDILLGHEAAALWNDKESSWIREASSRYKLLLQLLENCRHNTMARLEEVHRRQREELRSREALLEKVEKIRDEQFPKANLQQHQSSQNCCNPPERIVDGYQFPHNQDSIYKAERAYEEILQKEADRLKATEISTLHPTKQKPGLPYPYFKPGGNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFP6</accession>
    <name>A0A074ZFP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_06649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170233.1">
        <property type="nucleotide sequence ID" value="XM_009171969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFP6"/>
    <dbReference type="STRING" id="6198.A0A074ZFP6"/>
    <dbReference type="GeneID" id="20320828"/>
    <dbReference type="KEGG" id="ovi:T265_06649"/>
    <dbReference type="CTD" id="20320828"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025095633" description="Netrin receptor UNC5" evidence="12">
        <location>
            <begin position="23"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="140"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="14">
        <location>
            <begin position="698"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130337" checksum="203626CEF9922E7B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFZ7</accession>
    <name>A0A074ZFZ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174097.1">
        <property type="nucleotide sequence ID" value="XM_009175833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFZ7"/>
    <dbReference type="GeneID" id="20323846"/>
    <dbReference type="KEGG" id="ovi:T265_09678"/>
    <dbReference type="CTD" id="20323846"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12101" checksum="508083B3585B901F" modified="2014-10-01" version="1">MPSELYYGYRNLCTNTLIQKLQTCNEADEKHARNETKTIKVNMEEPRLFVFRDAGVVARLFYYYAAKSIQVGEYAVQLKHNMTLPNLRTDKSGKRCQRTMGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG15</accession>
    <name>A0A074ZG15_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596915">
        <property type="protein sequence ID" value="KER22160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174081.1">
        <property type="nucleotide sequence ID" value="XM_009175817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG15"/>
    <dbReference type="GeneID" id="20323834"/>
    <dbReference type="KEGG" id="ovi:T265_09666"/>
    <dbReference type="CTD" id="20323834"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="497" mass="56274" checksum="825445AB780B32EE" modified="2014-10-01" version="1">MQTYFEDSSRERKEHNRYVRTSEYESVSACECENTMVSSYLVEGHCLNSVQRRRTRSGFGMKLSRCLGLTQGCEALHIEGALSVWSTSSGAESHSRFRAFKKLTFRTKCIKTTIACLQDVEGEGWTTLETDCRYCELIDNGRVVKRNCLYKKRKKKKCKHHFLCKIDFCNQCFGDGLGNLAVSQPSCLLRVAWQLGTERLLQVDYYYYFTPCEVTDIRTNWVIVSSHRTLLKISTAVLCVFVSHTRESPGRGDFGGCRYDTTNRSAVAPFRCLTAMPPKGCTRAGILPGCPSLDRESREAEVGFEPRTFRSVNSHSNHLSHLVPIPLSILPFLDCLTLTNGEKLGAFTSNQTIEVLCPPTLHRYTSRLSHQCLVESKRCAKDNIGALEGWPSEEDAFIRLGATTWDRQPQNYTPELVSVDYTDHREMFSPVYPRQTENMLVQPATVSATGKWDSMGNTAEHWRHNQWVSGDAYKTKNKTDHRQPIPTAADSRGGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGD6</accession>
    <name>A0A074ZGD6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_06464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169996.1">
        <property type="nucleotide sequence ID" value="XM_009171732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGD6"/>
    <dbReference type="STRING" id="6198.A0A074ZGD6"/>
    <dbReference type="GeneID" id="20320643"/>
    <dbReference type="KEGG" id="ovi:T265_06464"/>
    <dbReference type="CTD" id="20320643"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052123">
        <property type="entry name" value="Non-rcpt_Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46257:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE CORKSCREW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="116"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="315"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="593"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
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        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER26268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="860" mass="94904" checksum="A452DCDD33D2BA0E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGY4</accession>
    <name>A0A074ZGY4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGY4"/>
    <dbReference type="GeneID" id="20320498"/>
    <dbReference type="KEGG" id="ovi:T265_06316"/>
    <dbReference type="CTD" id="20320498"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="23924" checksum="D1395745602460F1" modified="2014-10-01" version="1">MVSDPPTELKTKYLVIRETTHKVAESSSTVHDRFRPSALGSSGRRSPRVSVNIMIYLNPNWTVFEKYTQLLVNLAFTIGRNKLFGTYLKNILGQLHRPIRVFERLTWNPAESVVGDVFMRLNVLNQAASRFSHYDIRDIAMHVAASSSTAEDRFRPSWGSSSRRSCLNTSQTGDPAGFQNIRLTETRGLRLPDEPQEGRNRSSAVEELAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHI9</accession>
    <name>A0A074ZHI9_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596884">
        <property type="protein sequence ID" value="KER22700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175286.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZHI9"/>
    <dbReference type="GeneID" id="20323434"/>
    <dbReference type="KEGG" id="ovi:T265_09261"/>
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    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="1401"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1638"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1710"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1710"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1750"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1797"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1833"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1895" mass="205196" checksum="E3EAC695F4C30EAF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIJ8</accession>
    <name>A0A074ZIJ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169445.1">
        <property type="nucleotide sequence ID" value="XM_009171181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIJ8"/>
    <dbReference type="GeneID" id="20320204"/>
    <dbReference type="KEGG" id="ovi:T265_06022"/>
    <dbReference type="CTD" id="20320204"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14967" checksum="0EC7AFDCE5C7AAF0" modified="2014-10-01" version="1">MVLTHLRWNSRQGVVTIKKLDAVSLAEEGFVGRPPPLLASLQLNVLHTGRLMFQYDIRDIAVYFYKGDYSSTAHDRFRPSWGSSAVASFGYLTSMPGCPGLDRESREADVRFEPRTFRSVNSRSNHLGHLAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ80</accession>
    <name>A0A074ZJ80_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172842.1">
        <property type="nucleotide sequence ID" value="XM_009174578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ80"/>
    <dbReference type="STRING" id="6198.A0A074ZJ80"/>
    <dbReference type="GeneID" id="20328809"/>
    <dbReference type="KEGG" id="ovi:T265_14643"/>
    <dbReference type="CTD" id="20328809"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000073">
        <property type="entry name" value="High mobility group protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="32737" checksum="EDFAB5D0599A2C9F" modified="2014-10-01" version="1">MMVKDKNRPKHPMSAYACFVQVIREEHRKKHPNENVIFSEFSKKCAEKWKQMSNEQRRCFEEMAKLDLDRFNREMAHYVPPAGMRRGRRRRRTKDPAMPKRSWSAFFFFCDAFRSKIRNEHPDWKVSDIAKELGRRWEECTDKEKYERHAQNDKLRYEQDMQKYKAGIYVATKRARVEEDEDIEPSCVTVAPGDSHRQATDTSDGPAHVVAEEEEPEEDEEEEDEEEEEEDGEDEEEEEDGGEEDEEHVSTAGDAQRLSNAKPAILPRAAPDELEHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKE5</accession>
    <name>A0A074ZKE5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170039.1">
        <property type="nucleotide sequence ID" value="XM_009171775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKE5"/>
    <dbReference type="STRING" id="6198.A0A074ZKE5"/>
    <dbReference type="GeneID" id="20320680"/>
    <dbReference type="KEGG" id="ovi:T265_06501"/>
    <dbReference type="CTD" id="20320680"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="34278" checksum="F0D4C21218DD63E2" modified="2014-10-01" version="1">MGEAREVHAEDGSLYRTVCRSRHSVDWHTPNRMNHKSGATKSIKPRRPRATMRERQRMAQVNQAFDGLRKVVPRGHMTEYQRLSKIATLRLAIQYIRAMNRILGRTVYVSMEPTLNVPLEESMWERTTEKPTDNKSNGRREQAGRAGGEVVTRTSSQSDCGDIHSAENKVLFLFGCSPQLGWLGPQTESPRRDIGLLPADDDGKLMRDGCYIPNSNRNCNQPSTTSQTEKEQYAVTEYRWENKGNQVGNYFLSERGWQSRDHQTARKTAYYGWHGDATEQEHFGNAVSDGWLACEGTWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKW5</accession>
    <name>A0A074ZKW5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_08249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596827">
        <property type="protein sequence ID" value="KER24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172260.1">
        <property type="nucleotide sequence ID" value="XM_009173996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKW5"/>
    <dbReference type="STRING" id="6198.A0A074ZKW5"/>
    <dbReference type="GeneID" id="20322428"/>
    <dbReference type="KEGG" id="ovi:T265_08249"/>
    <dbReference type="CTD" id="20322428"/>
    <dbReference type="OrthoDB" id="6358729at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="231" mass="25849" checksum="D9C5B39CC62927DC" modified="2014-10-01" version="1">MTFTKFEFCRTGTSPTVERLDEAQITGAFPALFTQGFSYPITAEEAHRLQANMNQTFHTVIWTTEFVPTSPSPNTTVSVPHSYQYWALILFIFPLVTVFGNMLVVLSVIREANLHTATNYFIVSLAGADISLAVLVMPMSAWVESTRGKFLLMLMYGRHPCLPVDQEIGSGPATRLSPEEIEEERRRARENLTAVQERTGQKTASRKARPLPIGTKVKWKDRQNPGRSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLK6</accession>
    <name>A0A074ZLK6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168027.1">
        <property type="nucleotide sequence ID" value="XM_009169763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLK6"/>
    <dbReference type="GeneID" id="20319085"/>
    <dbReference type="KEGG" id="ovi:T265_04903"/>
    <dbReference type="CTD" id="20319085"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="18399" checksum="49E7CF0CFC20E232" modified="2014-10-01" version="1">MTQLVTEVRKPPYHESSRGSVSQLHLQSSLVLFTLRQCDLYSLMDQIRGLYIQRTHESCQCLSAIDSGGLIQSDGLGRTGSATSLVLPSGGMAVRRRKCATADRLFSHRIGTLILNSVVDDTGGNGPIAQSGVIVYENDHFKCVAVDSQTEVPSPPMLGCIPSAFQLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM30</accession>
    <name>A0A074ZM30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169464.1">
        <property type="nucleotide sequence ID" value="XM_009171200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM30"/>
    <dbReference type="GeneID" id="20328099"/>
    <dbReference type="KEGG" id="ovi:T265_13932"/>
    <dbReference type="CTD" id="20328099"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="500" mass="56334" checksum="62CB0FCB16D8EBA4" modified="2014-10-01" version="1" fragment="single">FPRDPKRIYKKVYYSHASPSVVSPLHPQYRPSSLRVAYYAFGNNSRYLLPLNTSKLSCEKSSTCASLTRSSAETFACSGVRIQVRPTCDGGIVVARSPRMSAPFRCLAAIPHEGGTRAGILRECPDLDRGSREAEVGFEPRTLWSVNSRSNHLDHLAPEKHCIAVVIREATQYVINVNYDNLESSLKQGSRFTTGFSFIQCEMTQWLQRKFTDRKVRGSNPASASQLSLSRLGQPGSITALVLPSNSMAARHRKGATAERSLFIFIFYPVLQWAKKKHFRWSFILHTFQDNFVNKDFNCGLHLRALVCSLVKLANERMLDPTMSKLGQPGGIPTIILPSGGVEVRHQKVTVAERYDVAENSSTDHGRFCPYWSSSGKQSGFKQNIRLLETLELYRDISNIVPTETSGDLVQLLRHIINELTHLQINLVSTSDSTEPLVYDTPQLNVLHTGCLMFQLARYSRYRISRENQIDLQMSVFFKNSPIWVQVEHKTDGNLKTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN59</accession>
    <name>A0A074ZN59_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171496.1">
        <property type="nucleotide sequence ID" value="XM_009173232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN59"/>
    <dbReference type="GeneID" id="20321838"/>
    <dbReference type="KEGG" id="ovi:T265_07659"/>
    <dbReference type="CTD" id="20321838"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8849" checksum="1898A636905277D5" modified="2014-10-01" version="1">MYCGEGRRAVQNHFRVTSLLKNPEGKSAVQWNSSDDQAYQPKQEEPSDEVSRLSARTHWRGDVKCAMSENAVGEPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNG1</accession>
    <name>A0A074ZNG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171363.1">
        <property type="nucleotide sequence ID" value="XM_009173099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNG1"/>
    <dbReference type="GeneID" id="20321728"/>
    <dbReference type="KEGG" id="ovi:T265_07549"/>
    <dbReference type="CTD" id="20321728"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="382" mass="43424" checksum="FCFD8544CB166C37" modified="2014-10-01" version="1">MERYENLGLVGEGSYGMVMKCKDRGTGQIVAIKKFIDTEDDKLVKKIAAREIKMLKQLRHDNLVNLLDIFRRKRRLYLVFEFVDHTVLDDLELHPKGLDEERTRRILFQVLRGVEFCHTQNPKIAAQKKEAVYLFKLRNGFCLCHNILKAAALADVKRLLLDFRGWFDSVDRSLFLYTLAYQGITRKLINVIRSLYSQTSGRVTVYGELSKRFRTQSGVLLFNFVIDEIMRRTLEGLQNPGVQITCEENLVDLEYADDIVLVFEGKAKAKVFLDELTKIIKNRSPVALFWCLAAMPHEGGTRAGLLPGCLNLDRGSQEAAVGSEPPTFRSVLLVDVQSPSTPLTIQKEVLEVVERFTYLGSCISSDCSVAEVNARIESRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNW7</accession>
    <name>A0A074ZNW7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168763.1">
        <property type="nucleotide sequence ID" value="XM_009170499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNW7"/>
    <dbReference type="GeneID" id="20327945"/>
    <dbReference type="KEGG" id="ovi:T265_13778"/>
    <dbReference type="CTD" id="20327945"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7166" checksum="F4FA6FD727B9A1D7" modified="2014-10-01" version="1" fragment="single">RSEFRQPVLSLSLGVGRHQVTVIQGCPACTPHDPPVLIVHGTGHSLFMLPVFHNNQPGFRISEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP77</accession>
    <name>A0A074ZP77_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPPC11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168596.1">
        <property type="nucleotide sequence ID" value="XM_009170332.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZP77"/>
    <dbReference type="GeneID" id="20319523"/>
    <dbReference type="KEGG" id="ovi:T265_05341"/>
    <dbReference type="CTD" id="20319523"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025876">
        <property type="entry name" value="TRAPPC11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12742">
        <property type="entry name" value="Gryzun-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="9">
        <location>
            <begin position="329"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 11 C-terminal" evidence="10">
        <location>
            <begin position="1445"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1554" mass="175273" checksum="B2D4C32C0EDE9F0F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP89</accession>
    <name>A0A074ZP89_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167077.1">
        <property type="nucleotide sequence ID" value="XM_009168813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP89"/>
    <dbReference type="GeneID" id="20327595"/>
    <dbReference type="KEGG" id="ovi:T265_13428"/>
    <dbReference type="CTD" id="20327595"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8949" checksum="7DC87AD2A9A30590" modified="2014-10-01" version="1" fragment="single">MKNHLENQIDLQLRDAVNNQLHQRTIRNVGYRLGRRKRLFEKRCRISDFALIFALFGIVVMLVETELTFIGVYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPD7</accession>
    <name>A0A074ZPD7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166937.1">
        <property type="nucleotide sequence ID" value="XM_009168673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPD7"/>
    <dbReference type="STRING" id="6198.A0A074ZPD7"/>
    <dbReference type="GeneID" id="20318224"/>
    <dbReference type="KEGG" id="ovi:T265_04038"/>
    <dbReference type="CTD" id="20318224"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14313">
        <property type="entry name" value="UBA_II_E2_UBE2K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000010">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22023" checksum="27DAA0EA39A2860E" modified="2014-10-01" version="1">MSSIAAKRIQKELAELLRSDEVAQNQIEIKPSGDDIMHLQGVINGPPDTPYNGAKFQLEIIIPSNYPFVPPKVKFLTRIWHPNISSATGVICLDVLKDQWAAAMSLRTVLLSIQALLASPEPDDPQDAVVANQYKSCPAAFDRTAQYWAAIYAGGPFKDTECNSLVDQLVSMGFDEHESRCALSMKNWDLPQATEHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPK5</accession>
    <name>A0A074ZPK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167187.1">
        <property type="nucleotide sequence ID" value="XM_009168923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPK5"/>
    <dbReference type="GeneID" id="20318416"/>
    <dbReference type="KEGG" id="ovi:T265_04230"/>
    <dbReference type="CTD" id="20318416"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10132" checksum="25BD63E5640899FF" modified="2014-10-01" version="1">MESLTNVPHNGRQAEISSQSTISLLNEKQYKCASVLIIQLDRLAPSNSRLSIVPNKRCVNNSQMKTNVVYVEVADNGLASFVPGANRIRFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ95</accession>
    <name>A0A074ZQ95_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170765.1">
        <property type="nucleotide sequence ID" value="XM_009172501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ95"/>
    <dbReference type="STRING" id="6198.A0A074ZQ95"/>
    <dbReference type="GeneID" id="20321251"/>
    <dbReference type="KEGG" id="ovi:T265_07072"/>
    <dbReference type="CTD" id="20321251"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000891">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER25505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="705" mass="78841" checksum="20DDEAB102481178" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ99</accession>
    <name>A0A074ZQ99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167013.1">
        <property type="nucleotide sequence ID" value="XM_009168749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ99"/>
    <dbReference type="GeneID" id="20318289"/>
    <dbReference type="KEGG" id="ovi:T265_04103"/>
    <dbReference type="CTD" id="20318289"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13619" checksum="80E794C5A2004E06" modified="2014-10-01" version="1">MRRFSTFSCLETSQTRDSAGFQATECAAPDGLMFQSIRYSRYRDTCATSFASVVPEGSKTDATPTKNTNFCNSTFQESVAKQLNVLHQTASCFSRYDIRDIAIHVYLCNVLLIRLLRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQI3</accession>
    <name>A0A074ZQI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166828.1">
        <property type="nucleotide sequence ID" value="XM_009168564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQI3"/>
    <dbReference type="GeneID" id="20318143"/>
    <dbReference type="KEGG" id="ovi:T265_03957"/>
    <dbReference type="CTD" id="20318143"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705499" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16590" checksum="B013BF743E661ABA" modified="2014-10-01" version="1">MYTTMHFCAILLVPSCRATRKRQEGWDTAKLPKPRQGKSRDRGRVRTTDLPVYFESEGRWFKPDLRLFTPLSKFGQSGSIPALVLPSGGMAVRLRKGDSGCRIPIDEDGKSIQNRNKSGCGRDMELVHCNNSEVPTPPNTRSGNLDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR34</accession>
    <name>A0A074ZR34_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170468.1">
        <property type="nucleotide sequence ID" value="XM_009172204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR34"/>
    <dbReference type="GeneID" id="20321009"/>
    <dbReference type="KEGG" id="ovi:T265_06830"/>
    <dbReference type="CTD" id="20321009"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8948" checksum="A172FF6A47FDBBFB" modified="2014-10-01" version="1">MCIRTDLFADRWAKIHYQVHHCGFPNERDFGVSLLLAPSRTNKETAYLFDSALRINIQADYLSTSSTLLLNSFHSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRG9</accession>
    <name>A0A074ZRG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166604.1">
        <property type="nucleotide sequence ID" value="XM_009168340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRG9"/>
    <dbReference type="GeneID" id="20327483"/>
    <dbReference type="KEGG" id="ovi:T265_13316"/>
    <dbReference type="CTD" id="20327483"/>
    <dbReference type="OrthoDB" id="10386022at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="366" mass="41264" checksum="9E105AB7D48A7D79" modified="2014-10-01" version="1" fragment="single">VKTWLKQNNLSHYIPAICVDDIINTTSCDVTAVGNFYFHMHPTVNISLRHVEILNVLPMPPKSYCMKLSNLEYQFPLPKLNAFTEWDNSTAAEYVKTWLKQNNLSHYIPAICVDDIINTTSCDVTAVGNFYFHMHPTVNISLRHVEILNVLPMPPKSYCMKLSTPALQSQKLMACDYSLPLKAVGELSPAEKLGQILSAGDVNKLCEAALPFKNYGQYQRQSLCPSSPPNCLSFLPASPESSTNSLHPNVRKMSSKHEFLDVAMVSHRWFVTFPTHKKGLTVYRVIMRACFITLVFQVKAWLGQNNLSRHIPAICVDDVINTASCDVTAVGYFYFHVHPTVNISLRHVEILDVLPMPPKSYCMKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRN0</accession>
    <name>A0A074ZRN0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166459.1">
        <property type="nucleotide sequence ID" value="XM_009168195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRN0"/>
    <dbReference type="STRING" id="6198.A0A074ZRN0"/>
    <dbReference type="GeneID" id="20317840"/>
    <dbReference type="KEGG" id="ovi:T265_03653"/>
    <dbReference type="CTD" id="20317840"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="518" mass="57460" checksum="90B1B05ED11A1A91" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRQ7</accession>
    <name>A0A074ZRQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166103.1">
        <property type="nucleotide sequence ID" value="XM_009167839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRQ7"/>
    <dbReference type="STRING" id="6198.A0A074ZRQ7"/>
    <dbReference type="GeneID" id="20317557"/>
    <dbReference type="KEGG" id="ovi:T265_03370"/>
    <dbReference type="CTD" id="20317557"/>
    <dbReference type="OrthoDB" id="10259720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10665" checksum="DBA6D742C81618E3" modified="2014-10-01" version="1">MLHDFTFQVKRMEARLNLLRNKVMSEEAKQLQLESLEREMDLELNAQKTKIGMKLRQTGARLAEARAELATRERRLEQIEARYDTQPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRV3</accession>
    <name>A0A074ZRV3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">XPA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166433.1">
        <property type="nucleotide sequence ID" value="XM_009168169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRV3"/>
    <dbReference type="STRING" id="6198.A0A074ZRV3"/>
    <dbReference type="GeneID" id="20317821"/>
    <dbReference type="KEGG" id="ovi:T265_03634"/>
    <dbReference type="CTD" id="20317821"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="11">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="49474" checksum="43CDDBE624B74F04" modified="2014-10-01" version="1">MRLFRHQEASDWASEDVRIRLRYGLFCCALVRFDNFGRRIGDVVRPLTTDVPEVWLESAGSSGFVMRLSGASVFCDADTRRSLICQKNLLLPSERLSLAIGNALSNFAYLKLLRMIMRVAKRHRPSATDGGFIPEDEVSEDQTLSQQFEKDEELTDDEFESGCQRRTKRHRRIRGLPLSSTEHGPPDVDHPLPLPPDEDKPLCDQCNRTFDDSFLRKHFDVDVCDRCRDPKGLHTMITKSTAKDRYLVNDVDLDVREPKLRFILKRNPHNSIWGDMRLYLEAQVAQRSLEIWGSEDKLEAERERRARRVEASKLKHYNKRIKELKVQTRSSLFTKTTATHEHSFGPETYDREKDVYVKRCTECNYTNICLVVVVGNLYLHTKLPASTSNAQLLTPPPRIIGERNCGSCNHCTTSTRSLQVTMMMLLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS26</accession>
    <name>A0A074ZS26_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_03525</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166301.1">
        <property type="nucleotide sequence ID" value="XM_009168037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS26"/>
    <dbReference type="STRING" id="6198.A0A074ZS26"/>
    <dbReference type="GeneID" id="20317712"/>
    <dbReference type="KEGG" id="ovi:T265_03525"/>
    <dbReference type="CTD" id="20317712"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705510" description="Beta-1,4-galactosyltransferase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="241"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="42271" checksum="6869DFF5DB472521" modified="2014-10-01" version="1">MRRQSKLVVLLLLATVILSSRVYLKELLSVISETSQSKQMPYDTSLRKAPPRVLSLSEQVQKNSTPGAVFQQTCSNICRQLPGNLTLQEMSLKFVGNLTISKEELAHRDLQSLSQKFQPHVRGGSWMYRDPSLNATNRCNVSNSSAVSIIIPLRNRWYQIPPLLSTLVPLLRKQKICYRVFVVEQADGGLFNKGKLFNSGFIEASKLFRFGCVVLQDTDLVPVNDLIPYGCDEETSKHVIHLGVGLDDRNYELRYPKLIGGVLKMTTGQFVSVNGFSNEYWGWGQEDDDMEKRLRQRNIDYIHISPAIARYASMPHEQQERVRRSEHLRLLKTAHLRMHTDGLNSVKYKLIHLEESTLFTLILVDVRDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS79</accession>
    <name>A0A074ZS79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170021.1">
        <property type="nucleotide sequence ID" value="XM_009171757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS79"/>
    <dbReference type="STRING" id="6198.A0A074ZS79"/>
    <dbReference type="GeneID" id="20320662"/>
    <dbReference type="KEGG" id="ovi:T265_06483"/>
    <dbReference type="CTD" id="20320662"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16053" checksum="3CC097E326594E1E" modified="2014-10-01" version="1">MALHVPKAPGFMSMLKEGARYFEGLEEAVFRNIEACAALSKTTRTTFGPAGQNKIVINHIGRQFVTNDAATILKELEVAHPAAKILVMATQQQEQEAGDGTNFVLQLAGSLLEQATDLLRMGLSVTQVTEGYELARTKALDTLDGNSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTZ6</accession>
    <name>A0A074ZTZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166943.1">
        <property type="nucleotide sequence ID" value="XM_009168679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTZ6"/>
    <dbReference type="GeneID" id="20318230"/>
    <dbReference type="KEGG" id="ovi:T265_04044"/>
    <dbReference type="CTD" id="20318230"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9012" checksum="B26C293B355CDA59" modified="2014-10-01" version="1">MPPDKLLDDEAEPDTIPNTIRPQYLHAITELTTCIFEKCIFIGEVSNCIKTDRSGHRTVSTLVQACGCSPPKTLARDRSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU19</accession>
    <name>A0A074ZU19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598702">
        <property type="protein sequence ID" value="KER18684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177569.1">
        <property type="nucleotide sequence ID" value="XM_009179305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU19"/>
    <dbReference type="GeneID" id="20326361"/>
    <dbReference type="KEGG" id="ovi:T265_12193"/>
    <dbReference type="CTD" id="20326361"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11059" checksum="BF9E77355047F740" modified="2014-10-01" version="1">MVHSDENFTLGSEQAPGRLFHPYQRKRLDYGVPKIHSPHTEAESNENKALFVADYRGFVQSQWIRSTLPESMKTFGCASTLKTLTGTALPLSFRLRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU85</accession>
    <name>A0A074ZU85_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165165.1">
        <property type="nucleotide sequence ID" value="XM_009166901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU85"/>
    <dbReference type="STRING" id="6198.A0A074ZU85"/>
    <dbReference type="GeneID" id="20316791"/>
    <dbReference type="KEGG" id="ovi:T265_02603"/>
    <dbReference type="CTD" id="20316791"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040689">
        <property type="entry name" value="SUVR5_Znf-C2H2_3rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18868">
        <property type="entry name" value="zf-C2H2_3rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="345" mass="38203" checksum="D771C3F1A9C277B7" modified="2014-10-01" version="1">MAETASGILQCFNCDAKFEDTQKFWDHIYNVDCGTNEDTTNFPKENLKPASSPARPKEQAASVEVCVSPTESTRGRDSFLCGLCNETFGSNNDLYAHTQSANHRERVASAANRYVTGNNPKKWPNKWLSEDPQQPLFCEDCQVPLPSLAAKDAHIIGKKHQRVIALLAMKKTPGWTPGQVTSSIRNDATRSYGLEKVETSHLFCEYCQVTLPDRQAARLHLTCNDHIEAMSKHNNCGVHPTTPNQTGTIQSSLSPLADSNMSELNALLRRLCLTQLLALMHGLDGAVYKGGGPTTCPPNEEAFARVNERDLLQLFRAICREELQNLLSQSNKSFPCLDDSKPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUL7</accession>
    <name>A0A074ZUL7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CLIP1 zinc knuckle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169216.1">
        <property type="nucleotide sequence ID" value="XM_009170952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUL7"/>
    <dbReference type="STRING" id="6198.A0A074ZUL7"/>
    <dbReference type="GeneID" id="20328051"/>
    <dbReference type="KEGG" id="ovi:T265_13884"/>
    <dbReference type="CTD" id="20328051"/>
    <dbReference type="OrthoDB" id="5412539at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="7">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CLIP1 zinc knuckle" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="345" mass="38677" checksum="91181381827DBEFE" modified="2014-10-01" version="1" fragment="single">SEDKQQQLEANLEVLRGELSDACKKQEELLRALATSNGIRDRLVSELSALLDVLPVAGESSVEDLTQGLRRRIDQLSKHVADAEASRDQLMSRVQVLESERAELERELTLLKISSSVRENEPDIATVTEQLEAAKTKMAQLEANAEAALHRLEGKSAELQAVQKQLDHTLNEHSQLKQSHEQAMAMMETERRQLLDRIQTIESNSAGFAGSEASVPNDELTRLIGEKTSAESQVSFLNSIIVDLHKKNAELEERVRSMLLVLDTPPVKTVLAAPLPRPPRPWCDNCLVFDSHETENCPRVVENGTLHPKKRVSLQKIELTERMYCDICGVFDNHNTEDCTNNETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUZ4</accession>
    <name>A0A074ZUZ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_13838</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Synaptic cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169080.1">
        <property type="nucleotide sequence ID" value="XM_009170816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUZ4"/>
    <dbReference type="STRING" id="6198.A0A074ZUZ4"/>
    <dbReference type="GeneID" id="20328005"/>
    <dbReference type="KEGG" id="ovi:T265_13838"/>
    <dbReference type="CTD" id="20328005"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19033">
        <property type="entry name" value="LGIC_ECD_nAChR_proto-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022264948" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="13">
        <location>
            <begin position="25"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="87"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="817" mass="93534" checksum="92D626D5047EE1A7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV64</accession>
    <name>A0A074ZV64_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168988.1">
        <property type="nucleotide sequence ID" value="XM_009170724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV64"/>
    <dbReference type="STRING" id="6198.A0A074ZV64"/>
    <dbReference type="GeneID" id="20319841"/>
    <dbReference type="KEGG" id="ovi:T265_05659"/>
    <dbReference type="CTD" id="20319841"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048257">
        <property type="entry name" value="DUF4590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027962">
        <property type="entry name" value="ERICH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15257">
        <property type="entry name" value="DUF4590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4590" evidence="2">
        <location>
            <begin position="357"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1025" mass="114116" checksum="88FB07FE47E0B46F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVL4</accession>
    <name>A0A074ZVL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597298">
        <property type="protein sequence ID" value="KER19184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177068.1">
        <property type="nucleotide sequence ID" value="XM_009178804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVL4"/>
    <dbReference type="GeneID" id="20329791"/>
    <dbReference type="KEGG" id="ovi:T265_15626"/>
    <dbReference type="CTD" id="20329791"/>
    <dbReference type="OrthoDB" id="10335363at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29982" checksum="62C7A4D560BA11D4" modified="2014-10-01" version="1">MDSISTHRFRLTPGVPILCDFNNSRLLLKIRRQPTTGFALFGSLQAQSPGFRQTYVLPETKLHEISEYTLICLRTSQTRESAGFQWDPSCDRCVRHCDRNSFVNSRYEPVCSHSVRPAPLRRRQLLQCFYRPSNDQSSTDRPTNRVTQTLSEDATLVDIKGDHPLDPQTEVTLSRLTVPGAEGVSLKGSRHDGPLQFRPDPNKKSFAKQLSVVPSIIHPSQTTTDVQVHPRPPRGMEVSFSIGGGDSVLSRASTPNERNSQGTLNEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWB0</accession>
    <name>A0A074ZWB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo/beta-catenin-like repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164517.1">
        <property type="nucleotide sequence ID" value="XM_009166253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWB0"/>
    <dbReference type="GeneID" id="20316282"/>
    <dbReference type="KEGG" id="ovi:T265_02094"/>
    <dbReference type="CTD" id="20316282"/>
    <dbReference type="OrthoDB" id="278163at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041090">
        <property type="entry name" value="DUF5578"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34258:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17741">
        <property type="entry name" value="DUF5578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58743" checksum="0B024301ED048A5A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWP4</accession>
    <name>A0A074ZWP4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168483.1">
        <property type="nucleotide sequence ID" value="XM_009170219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWP4"/>
    <dbReference type="GeneID" id="20319432"/>
    <dbReference type="KEGG" id="ovi:T265_05250"/>
    <dbReference type="CTD" id="20319432"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10584" checksum="6F0D8FA48F78C21B" modified="2014-10-01" version="1">MDENIALGPDMIVHGDETLEALGQRPARGNTSRSHGSTPVRSRLGAMRSNLEMDSCQSTNPDRSVGEKHPKLGTVQYSKRKGHQGDRAQPTKNGRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWX4</accession>
    <name>A0A074ZWX4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165837.1">
        <property type="nucleotide sequence ID" value="XM_009167573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWX4"/>
    <dbReference type="STRING" id="6198.A0A074ZWX4"/>
    <dbReference type="GeneID" id="20317347"/>
    <dbReference type="KEGG" id="ovi:T265_03160"/>
    <dbReference type="CTD" id="20317347"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="480" mass="52703" checksum="1B602EC83FC9E562" modified="2014-10-01" version="1">MLPASDTGFSYVIGREREQRELLALLGQNDPVSSCIVLTGPSGCGKSVLLSSTFTQLQRLYGQKWILVSCLEGCCSPTHSVSANVSSKLLFELIIHSIVSKCTPQSTATAYRCDGPAAFVEILSDLLRTMKNADPVSPVSLVLVLDQAEKLRDSDPLLLPLLVRLGSLVQDNLNLVDNRIDARLVTLLITRSPWEKFSSGTFHLEPVVLAMSSYSRDQMTQILLSLRPPEASELRFSRFVDLLLTVCFPVCRSAGEIIHLMQVNWPAFEEPVVKGLVGPDDEWGQWKLAQPTLKRSLATLYLRPQSSSTACADGEGIIPATTLELPYFSRFMLIASFLASYNPREADKKFLVKNTGKLSTQRKRREKKTERGPRLFPLDRLFAIFHAILRDQAEPTLCTSLLVSQVACLTALGLLSAASPANAIGGLYTTGMFSGSASLNDVDSLANPRYRCLLSFEAAKTIAQSLDFDLPAYLTDFCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXU8</accession>
    <name>A0A074ZXU8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integrin alpha third immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164401.1">
        <property type="nucleotide sequence ID" value="XM_009166137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXU8"/>
    <dbReference type="STRING" id="6198.A0A074ZXU8"/>
    <dbReference type="GeneID" id="20316187"/>
    <dbReference type="KEGG" id="ovi:T265_01999"/>
    <dbReference type="CTD" id="20316187"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0401">Integrin</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001422738" description="Integrin alpha third immunoglobulin-like domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="10">
        <location>
            <begin position="285"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="10">
        <location>
            <begin position="378"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="13">
        <location>
            <begin position="831"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1229" mass="133756" checksum="487B2F36815F5A99" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXW2</accession>
    <name>A0A074ZXW2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL597102">
        <property type="protein sequence ID" value="KER20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176217.1">
        <property type="nucleotide sequence ID" value="XM_009177953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXW2"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325494"/>
    <dbReference type="KEGG" id="ovi:T265_11326"/>
    <dbReference type="CTD" id="20325494"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705558" description="Hemoglobinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="325" mass="36954" checksum="EF3657DAECF300C9" modified="2014-10-01" version="1">MELQVCLDMMRRCSLLIALVFCIDHVACLEAPGVQNLSSIFNNKPSKNWVVLVAGSDDWINYRHQANVFHAYHVMRANKIPAENIITFAYDDIANNPKNPYKGQVFNDYEHEDVYKGVVIDYRGQDVNPDIFAKVLKGDKKLEKEGKKILKSGPDDNVFIYYTGHGASQAISFPSGYLHAVELNDILGSMYLNKRYNKLVLYVDSCSAGSLFRDLLPSDVGIFVTTSANEDEQSWSSFCNDKRIGVCLATEYSYGWITDSEYKDLKKRTLDQQYEEVKKRTKKSHVMKYGEMVPELARYTPHLMELCKAGYETATLIESVHSVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY65</accession>
    <name>A0A074ZY65_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163840.1">
        <property type="nucleotide sequence ID" value="XM_009165576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY65"/>
    <dbReference type="STRING" id="6198.A0A074ZY65"/>
    <dbReference type="GeneID" id="20326966"/>
    <dbReference type="KEGG" id="ovi:T265_12798"/>
    <dbReference type="CTD" id="20326966"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="597" mass="64681" checksum="82398DB1EB4F1DA0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYY3</accession>
    <name>A0A074ZYY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165025.1">
        <property type="nucleotide sequence ID" value="XM_009166761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYY3"/>
    <dbReference type="GeneID" id="20316686"/>
    <dbReference type="KEGG" id="ovi:T265_02498"/>
    <dbReference type="CTD" id="20316686"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="91"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="304"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="537" mass="59960" checksum="96F584C7E97B6C3A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ41</accession>
    <name>A0A074ZZ41_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM149 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164958.1">
        <property type="nucleotide sequence ID" value="XM_009166694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ41"/>
    <dbReference type="STRING" id="6198.A0A074ZZ41"/>
    <dbReference type="GeneID" id="20316633"/>
    <dbReference type="KEGG" id="ovi:T265_02445"/>
    <dbReference type="CTD" id="20316633"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022194">
        <property type="entry name" value="DUF3719"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039630">
        <property type="entry name" value="FAM149"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31997:SF1">
        <property type="entry name" value="AGAP003710-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12516">
        <property type="entry name" value="DUF3719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3719" evidence="3">
        <location>
            <begin position="431"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127112" checksum="2E844C3D219B3DA6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ58</accession>
    <name>A0A074ZZ58_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165015.1">
        <property type="nucleotide sequence ID" value="XM_009166751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ58"/>
    <dbReference type="GeneID" id="20327185"/>
    <dbReference type="KEGG" id="ovi:T265_13017"/>
    <dbReference type="CTD" id="20327185"/>
    <dbReference type="OrthoDB" id="6244380at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="461" mass="50920" checksum="1F87718F5EEAA3A1" modified="2014-10-01" version="1">MNPYSFKRFLQNPERRRHPVQLVRSDANSVIVQGDLPDCVQNQHTALSSPTPDINPSHVQPAETISTTSLGFSSAIHRSPQEILGTSAFTQTSHPSEVTAPQRGVTSPSTAPLPDVHPSNFVEDLPPLVRCTSHSAWTTHTLDILSGGLPDFISDERQENREQLFSEAESSRYQFPVISPNTPFFDSSSHSSSLPLLPVEETSTVGSGNQFLCRSHEHLLEPPSSPSQPGITQLLRNEPAATLNGVTNVPDATDGFSVLPQPDVPVIGPEQHRYIINSVTSRQSELEKELDQTRRLLIERDRELITVRAQTEVLLREAELRIKSLEHDLAKEKLRSARGHWAFVQLRNHFSVNGEGVPTNLRLPVTTDSYAEVDEAVPVPDSFNVMLSGCCTTDPGRPRSPTEIPIAADRQEPGGIAEGDVLTSLMRYAEPLATENEQFQTESVHEPDNIEEGVHRDVHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A001</accession>
    <name>A0A075A001_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167368.1">
        <property type="nucleotide sequence ID" value="XM_009169104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A001"/>
    <dbReference type="GeneID" id="20327656"/>
    <dbReference type="KEGG" id="ovi:T265_13489"/>
    <dbReference type="CTD" id="20327656"/>
    <dbReference type="OrthoDB" id="6237770at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="361" mass="42107" checksum="F5768F192F381595" modified="2014-10-01" version="1" fragment="single">MAAPDVRIIVRPEQDFYLFNQEQPVHFRVSAKDETVQHAEILRSVRLNCTVYDPKGQQVTFKTKPNDTTTVYSYVSFALRKKSYKSGVYRYQCRAISENLKLEKVLTIIDYLTVNPLAEGEMFIPLSDRKKVTLIIKNRGKQIHYTNEVHNYVCVLLCYLTMHYLTVNPLAEGEMFIPLSDRKKVTLIIKNRGKQIHYTNEVHNYVCVLEGPPIDALRFQRNEPRWISRENSKSAVALENVLYVTEEASIGYYHYRCFYNKNGLKLHSELRFSVLDKNLMTLDIDPIGHSTFVYHTQGIRPAFRCHTKYLGTNTLHRPIWRLLHGQSDFVIKDETDYTQSQSTVYLVDDKEGQSTFQCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A002</accession>
    <name>A0A075A002_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597026">
        <property type="protein sequence ID" value="KER20724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175511.1">
        <property type="nucleotide sequence ID" value="XM_009177247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A002"/>
    <dbReference type="STRING" id="6198.A0A075A002"/>
    <dbReference type="GeneID" id="20329413"/>
    <dbReference type="KEGG" id="ovi:T265_15248"/>
    <dbReference type="CTD" id="20329413"/>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="182"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="56916" checksum="1E824D7D418B8C87" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A026</accession>
    <name>A0A075A026_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167380.1">
        <property type="nucleotide sequence ID" value="XM_009169116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A026"/>
    <dbReference type="STRING" id="6198.A0A075A026"/>
    <dbReference type="GeneID" id="20327668"/>
    <dbReference type="KEGG" id="ovi:T265_13501"/>
    <dbReference type="CTD" id="20327668"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="6">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="20229" checksum="F4C2613A41308265" modified="2014-10-01" version="1" fragment="single">MIHSNTSRPEHLERIGVRRPKCARCRNHGLVAWVKGHKKFCAFRNCTCEQCILIVERQRVMAAQVALKRRQAVEDLLVQEWKKSQGALANHSHEEELEDSIRTERSDSWMEVHLASIPDSCMYPKNFPSRWCPKKHDQAHKWRNADDVFNVTHLVFEDASPAFAQPYSHCKKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A107</accession>
    <name>A0A075A107_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RNase3 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167121.1">
        <property type="nucleotide sequence ID" value="XM_009168857.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A107"/>
    <dbReference type="GeneID" id="20327607"/>
    <dbReference type="KEGG" id="ovi:T265_13440"/>
    <dbReference type="CTD" id="20327607"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
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        <location>
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            <end position="1117"/>
        </location>
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        <location>
            <begin position="1373"/>
            <end position="1507"/>
        </location>
    </feature>
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        <location>
            <begin position="1906"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="2159"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
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        <location>
            <begin position="915"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1335"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1593"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2308"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1335"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1612"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <end position="1685"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1690"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="2570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2570" mass="288308" checksum="7B1C47F37A2D8FFD" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A147</accession>
    <name>A0A075A147_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20324647"/>
    <dbReference type="KEGG" id="ovi:T265_10479"/>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="21321" checksum="18C13633B8C9595F" modified="2014-10-01" version="1">MQETGRTTGPPAGSRPHSNGTILSVTTESPAAFPTVMRILKMTWHVSQSEKIKESCSTLSAPVTTRRRHEGCDTAPSPKPRQGKLRGRGRVTEDAYDRHNPNWICFLNGTQFKLKGVYFHQAENYHRNNAEDVRCERESLENNYDVTRSPRTSGVWSSNPGTAIGYTLLMSSNSSETRVKCFTSFGVDPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A196</accession>
    <name>A0A075A196_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04057</name>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11043" checksum="792791B148F37513" modified="2014-10-01" version="1">MSPRLVMKRLQSNCPARQTSQRPPVYLSARKMSAAQCRWLLACSLSWAILIQTFHHQSSVTRVLLYVLLAGDDFCSRLVVRSGGSIGCPTVPCPHSPMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1C4</accession>
    <name>A0A075A1C4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20324623"/>
    <dbReference type="KEGG" id="ovi:T265_10455"/>
    <dbReference type="CTD" id="20324623"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9482" checksum="68251915F3C0B041" modified="2014-10-01" version="1">MKARKTKFRMNSQKKSGSSQHDCTRELVKRRPGIALGSDTDTIFGYMAVRDATVRGNSHYTELASEDYIHRQKAQRRSSTSACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1E3</accession>
    <name>A0A075A1E3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175078.1">
        <property type="nucleotide sequence ID" value="XM_009176814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1E3"/>
    <dbReference type="GeneID" id="20329319"/>
    <dbReference type="KEGG" id="ovi:T265_15154"/>
    <dbReference type="CTD" id="20329319"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11806" checksum="46635FBB2959DF2A" modified="2014-10-01" version="1" fragment="single">MMKPDVFVESLWHGRKPAASQKIEYIKKQLTIEENVGSSGSVDGGRWLVRWWLCTTTNPPLHTPTLHNNALMMSPGLVMKRLQSNCPAQRTSQRPDEKMFTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A273</accession>
    <name>A0A075A273_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162770.1">
        <property type="nucleotide sequence ID" value="XM_009164506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A273"/>
    <dbReference type="GeneID" id="20326753"/>
    <dbReference type="KEGG" id="ovi:T265_12585"/>
    <dbReference type="CTD" id="20326753"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8474" checksum="54FFB9446064E825" modified="2014-10-01" version="1" fragment="single">ANVSCGGLAARQQFEVCYTHYLCIRWNYAVHVHEICDAHTHTHSACDAATSRLLKAEKQAQTTCDHRTFRRKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2F0</accession>
    <name>A0A075A2F0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174692.1">
        <property type="nucleotide sequence ID" value="XM_009176428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2F0"/>
    <dbReference type="GeneID" id="20329227"/>
    <dbReference type="KEGG" id="ovi:T265_15061"/>
    <dbReference type="CTD" id="20329227"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="23194" checksum="B2E9DD5C3BE79732" modified="2014-10-01" version="1" fragment="single">GCCSVRRAWQLACKRFVTIRGDIISAPLSGYFFLACLPRHPTEARGPGNRQVARAQTRKFESQWSGSNPGLSINQLDVDLFAELGSFLANVSLPTSPTRFWTLITSPRLVTRLLQVNCQARQTGHQPPDLQPISVTDLPTFEYIVSMVVVGLFAELGNLIANVSSPIEVTSSGTTTNPPLRTTTLHKNALMMSPRLVMKRLQSNCPAQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2F5</accession>
    <name>A0A075A2F5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166524.1">
        <property type="nucleotide sequence ID" value="XM_009168260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2F5"/>
    <dbReference type="STRING" id="6198.A0A075A2F5"/>
    <dbReference type="GeneID" id="20317900"/>
    <dbReference type="KEGG" id="ovi:T265_03713"/>
    <dbReference type="CTD" id="20317900"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000962">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF4">
        <property type="entry name" value="MYOPALLADIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="508"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="990" mass="108651" checksum="92AF3EE0F891A246" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4J6</accession>
    <name>A0A075A4J6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165787.1">
        <property type="nucleotide sequence ID" value="XM_009167523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4J6"/>
    <dbReference type="GeneID" id="20317305"/>
    <dbReference type="KEGG" id="ovi:T265_03118"/>
    <dbReference type="CTD" id="20317305"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8413" checksum="D294051420FC9501" modified="2014-10-01" version="1" fragment="single">CSAIDNKKVDTKLFCAVPLQQTFKIVLFCSGFVLLRETSAILAYCTLRVIILLLILSSPMHPRNSRIHRLIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4N0</accession>
    <name>A0A075A4N0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163065.1">
        <property type="nucleotide sequence ID" value="XM_009164801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4N0"/>
    <dbReference type="GeneID" id="20315094"/>
    <dbReference type="KEGG" id="ovi:T265_00906"/>
    <dbReference type="CTD" id="20315094"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44477" checksum="C3379830C5295411" modified="2014-10-01" version="1">MALSGPFYRLSCVNSIPIPPVLSYDIPCRRRKVWILHIQLVYFCSEGEKVISHIRTLTNLVPLPIRGSRSETTNFYLFTEPRERWPKWLEREFTDRKVRDSNPTSASRLALSRLGQPGSIPALVLPSGGMAARHRKGATAERFLLLSQSRTRQIVITELSPRGGGGRDGPSGYSASLLTGGSVVRTRPQRLDFPCLGLGNPVVPQPSCFFRVAWHLCTGRVSQLNNFSPRGIWHPSSTSSLRNRFFGARISRQEHVPYRVESSHEGTESEKLYSTQCKLLYHNTLVGVKLFLALLEADTVVIQTILYNLNYSASRFGMRFTPAKCKVLLQDWTSLSTLAAVSVQVAWRKMNVRAAFVNIRHLWRRRSIHLTVKGQVYSTAVCSIFLCGSETWPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5X4</accession>
    <name>A0A075A5X4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165269.1">
        <property type="nucleotide sequence ID" value="XM_009167005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5X4"/>
    <dbReference type="GeneID" id="20316891"/>
    <dbReference type="KEGG" id="ovi:T265_02703"/>
    <dbReference type="CTD" id="20316891"/>
    <dbReference type="OrthoDB" id="10066870at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8365" checksum="A79684DB3168AEA1" modified="2014-10-01" version="1">MSINVDILLSRLPPTISSSAKAELGSVLSEYTDVFAWKDYDVGRTKAYNIRQTLEMLHPSAYHHDMSRFSTNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5X5</accession>
    <name>A0A075A5X5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162636.1">
        <property type="nucleotide sequence ID" value="XM_009164372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5X5"/>
    <dbReference type="GeneID" id="20314756"/>
    <dbReference type="KEGG" id="ovi:T265_00568"/>
    <dbReference type="CTD" id="20314756"/>
    <dbReference type="OrthoDB" id="6242189at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704504" evidence="2">
        <location>
            <begin position="23"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="492" mass="55284" checksum="5A8A18E47FC5F211" modified="2014-10-01" version="1">MGAVLFLSISSFLLLNWYHCESNFTKIPVLCPKGYWINEPKPRGGSSEPNVEDAICQFCPNVGCYVVRRKIQDDDDESGQSGTTMVPHTTTMSTTLATSQINVTEYTTETNGTIGIENRTNEEQINYRMYMSCDYWASLPKPEEIMSYLDCVMIGRRDKYYLFIYEPRFQASRFPIVDCVDANFLAWIPNGTQLLGLELGFPMKSIPPYLFRYHQRIMEETQYICIDGSSLENKSIPFADTERFASNKLVQVVFRKDSLRRDRRPPRGLEAPNRKDFQSEEDTIACPHIVHPLPANITPDADCQFSPSGLPTTSDRVDPTQAINRCPFRIQIKQKAIRRRKPNTGLLEELRVPPAFLSACLIVVVLLLTLGIITAFCIMNAEKLMLCKTRSRKRREREAAVASELAEQAAKEAAAAATVDAQERQPNSWHPIYGRFGMVPPTMGGAFGAFAARPLDAVTNQQQMGNMTANPGNAPRPTGMGYYLAQPNAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A615</accession>
    <name>A0A075A615_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="KL596875">
        <property type="protein sequence ID" value="KER22884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173371.1">
        <property type="nucleotide sequence ID" value="XM_009175107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A615"/>
    <dbReference type="GeneID" id="20323295"/>
    <dbReference type="KEGG" id="ovi:T265_09116"/>
    <dbReference type="CTD" id="20323295"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023978044" description="Leishmanolysin-like peptidase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER22884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="755" mass="85447" checksum="CF24CF90537808D8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A624</accession>
    <name>A0A075A624_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_13057</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165216.1">
        <property type="nucleotide sequence ID" value="XM_009166952.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A624"/>
    <dbReference type="GeneID" id="20327225"/>
    <dbReference type="KEGG" id="ovi:T265_13057"/>
    <dbReference type="CTD" id="20327225"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1831"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="384"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="20">
        <location>
            <begin position="1022"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="1325"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1456"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1704"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KER31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1856" mass="206641" checksum="AB16422A28196E44" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8K5</accession>
    <name>A0A075A8K5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009174149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8K5"/>
    <dbReference type="GeneID" id="20322544"/>
    <dbReference type="KEGG" id="ovi:T265_08365"/>
    <dbReference type="CTD" id="20322544"/>
    <dbReference type="OrthoDB" id="6252128at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="334" mass="38480" checksum="6454834184A5066E" modified="2014-10-01" version="1">MSRKGTSKKSSKTDPPRGSHMVDGYLVHTDTRQRLFYYVCVYTVFRKTLEAGEQLGPEEAIAVMKKHIRKRVARCVCFMLEDRLIFEKHKPKGKEPFRSWIAYEEIQDINRSPRKREVFVLSIITNREDHRYYEVYRCNKKDEAAQVEHYIQTALQDPGYRIHCGTPIDIVTVPEYQEKRRTIEGVCLENVSEGETSNEEELKGGQYHASVNGLRNSNITNHMYMNSNMWPGDEACVTSGDSLPVSTQNESHSSGATTPPTVFISRESAIQWENTPVRRHFLLESGPISATSPEFSNLRSVCELEDVTFVDVKSSSNDHGPVYLYLKRKPRWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8Q0</accession>
    <name>A0A075A8Q0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER23874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009174107.1"/>
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    <dbReference type="KEGG" id="ovi:T265_08339"/>
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    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="366"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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        </location>
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            <begin position="156"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1674" mass="179606" checksum="21C7DC5A0C25448A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAA6</accession>
    <name>A0A075AAA6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_01354</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAA6"/>
    <dbReference type="STRING" id="6198.A0A075AAA6"/>
    <dbReference type="GeneID" id="20315542"/>
    <dbReference type="KEGG" id="ovi:T265_01354"/>
    <dbReference type="CTD" id="20315542"/>
    <dbReference type="OrthoDB" id="10017443at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER32670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="418" mass="47281" checksum="3C920CEC2937C99B" modified="2014-10-01" version="1">MCHLCYSMHPFRDLPSVTQNGYSTHILPGSHSDSPLGAPCGKFGYRNGMAVTTDGYAPQAAYHTQSHHPHPHQNGHLHHSAQHPTHLDHSPLPHGHTTDHFHRRVWDVWAPNFHEGMQLLRQLGRECRYVAVDTEFPGVVAKVFGEYANSFEQAYHNIKVNIDMMKPIQIGFSFFNDRGQTVGDVSTVQFNIKWNVDNDTYADDSIKLLAFSGIDFEKLKRNGIELNDFAEAFIASGLALNDRITWIGFHSAYDFAYMMKICTDWKQMPDNFQEFQKRLLIFFPRIVDLKAMMSEHRFPKSGLQELADLMRVPRIGLRHQAGSDAMLTGETFFRFLEEHGGGKIDQRVVNLVYGLNYCPNGVSNTWVRMNTSSPQLDAAPTNRNIISCASTFYRNNVHSADHSGRSSPADSNSGHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAH2</accession>
    <name>A0A075AAH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009165238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAH2"/>
    <dbReference type="STRING" id="6198.A0A075AAH2"/>
    <dbReference type="GeneID" id="20315441"/>
    <dbReference type="KEGG" id="ovi:T265_01253"/>
    <dbReference type="CTD" id="20315441"/>
    <dbReference type="OrthoDB" id="5989495at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445">
        <property type="entry name" value="PROTEIN CBG24663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37445:SF3">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44518" checksum="97B706D209CF0C8E" modified="2014-10-01" version="1">MGIQRRSPPAFLAEPSENMENSTFCDSACAVGGPIYLRMIGFTGCAGEHQLPEYIVKHSSLTLIVSLGCVDMDTICDVSSLCSNCDLPVSDSDKALKCDICATWEHIECSHIHSSIYAALLAHPSDNLSFTCTRCKSISTSPLRKKQKSKKSKRYAPAPSSDLQDSLVRNVPDVNSVEPSVTLNAPMRSSDCTDEQNTQSPWLSTKRRHRMKTRPPAHDHEVVESLPVSSASAIQPTVSGNRETLKFPRDHCLMLFGSKESGEEGAQARYNHDLNLLQGLVDKLADADEPGIRVRRILRLGKRVAGIHRPLKIVFENADAPKHLLSRAWRLKGMDIYIRPDMDPSQRAQLKAAVVELRRRTLEGENDLRIVNFRIVKWRAFINRPVTLTARSQSHSLACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB75</accession>
    <name>A0A075AB75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171380.1">
        <property type="nucleotide sequence ID" value="XM_009173116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB75"/>
    <dbReference type="STRING" id="6198.A0A075AB75"/>
    <dbReference type="GeneID" id="20328486"/>
    <dbReference type="KEGG" id="ovi:T265_14320"/>
    <dbReference type="CTD" id="20328486"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="286" mass="32157" checksum="FAA8AF6B230EC706" modified="2014-10-01" version="1" fragment="single">MYQATLHDALLHGCGTWPIRAAELKHLQVFDNCYLRTMARVIHRDIKPENVLISKRGVVKLCDFGFARALAAPGEVYTDYVATRWYRAPELLVGDSKYGRAVDIWAVGCLAAEMLTGNPLFPGDSDIDQLYHIVRCLGNLSEKHQLVFKRNPLFSGMRIPAVRDVIPLERRLNKVRKSTLEFIKECLRLDANDRATASALLRSNYFTRDNFSTFFTEELKRLVQYENPTNDRTQSPKATNGGGDQSQTSLASTCGNLLPIFDTGSQPGDPKVHNNSNPVPYHSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADG3</accession>
    <name>A0A075ADG3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161968.1">
        <property type="nucleotide sequence ID" value="XM_009163704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADG3"/>
    <dbReference type="GeneID" id="20314235"/>
    <dbReference type="KEGG" id="ovi:T265_00047"/>
    <dbReference type="CTD" id="20314235"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="13949" checksum="CE8E0E66BA37C36B" modified="2014-10-01" version="1">MARRQHCSERSRSLLRSQSVHSASDADTLSTTNKANQTQTGSVLRHLNIQNIVVPSGEQHHKQEAQLGLRNTQPEVNKLIPFIGRVETSVLKHPDCQDTITLCSTEAGDVGSTRNNHSEPIMKDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADQ2</accession>
    <name>A0A075ADQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170076.1">
        <property type="nucleotide sequence ID" value="XM_009171812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADQ2"/>
    <dbReference type="GeneID" id="20320708"/>
    <dbReference type="KEGG" id="ovi:T265_06529"/>
    <dbReference type="CTD" id="20320708"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="310" mass="35587" checksum="5D1FA726C697F95D" modified="2014-10-01" version="1">MLNPPILYPSELGGRLCLHCKSANMIASVQLEVLGRRVTIEPSAKTKVDQLSKGSENRCMFHHFLTWLMVNMVNLQMMDVKSRGMMVLVVTYTNKTRRNNAMVRLTSCIHQLTKYLLMLREYRRSVRGDFEQLPTCGSFEYDESSNMCRGPPTKSNALSRESSLQDRWCRCNNGDLPVNTTDKQFARTLIDSFYWSNSILGTNFKSSQVSLMSLWHTLRSLLVATQDIPIFRTVLTLLNQTKSTFKGHYAYPNPEKKLEGMEISLKYCAPEILQNPVAYLFKNKSPWHRTGLSDPKPDAYSNFQPSECDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG02</accession>
    <name>A0A075AG02_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168039.1">
        <property type="nucleotide sequence ID" value="XM_009169775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG02"/>
    <dbReference type="GeneID" id="20319097"/>
    <dbReference type="KEGG" id="ovi:T265_04915"/>
    <dbReference type="CTD" id="20319097"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8544" checksum="D3C3A2E16022384A" modified="2014-10-01" version="1">MSKHSSVDGLQSDLLARLVSVEQLSANASRNAAWLWGRCTWTSVANLALSRRAARKQPFVKPRTCENMEIEDADKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG42</accession>
    <name>A0A075AG42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167877.1">
        <property type="nucleotide sequence ID" value="XM_009169613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG42"/>
    <dbReference type="STRING" id="6198.A0A075AG42"/>
    <dbReference type="GeneID" id="20327758"/>
    <dbReference type="KEGG" id="ovi:T265_13591"/>
    <dbReference type="CTD" id="20327758"/>
    <dbReference type="OrthoDB" id="10262005at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21340">
        <property type="entry name" value="PPP1R42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29128" checksum="8DDFC78198B2927A" modified="2014-10-01" version="1" fragment="single">MVKSTVALLCKSTSNLKKRKIDETPDQYLKKITHLYLNGKHLDEVGPELALCKQLNVLYLYDNMLKEFPDLSVLTQITHLYLQNNQITRIDNLGSLARLEKLFLSRNCISLVEGLEGLTALQELRLDNQKLYPGESLLFDEQSVTSIAETLTRLDVSGNALETLEDLTPLKKLLYLSAGNNHIKSIRKLSEVLPSWPALTHLELQGNPVMKKLRVRDAIVVNTKSLEMLDNKPIPETTRQFLENWNHVKGIRLDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGD7</accession>
    <name>A0A075AGD7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167620.1">
        <property type="nucleotide sequence ID" value="XM_009169356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGD7"/>
    <dbReference type="STRING" id="6198.A0A075AGD7"/>
    <dbReference type="GeneID" id="20318763"/>
    <dbReference type="KEGG" id="ovi:T265_04581"/>
    <dbReference type="CTD" id="20318763"/>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11623" checksum="CBF5F6A8448D711C" modified="2014-10-01" version="1">MITLLQRISELPEDAVKAALHAKERKHRLDVKERRRQEQQKHQEERLRKTLERAQAEPKMMHGRKIVARSEPPKMSKDDSKDLEALAKEEEEMRVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGG1</accession>
    <name>A0A075AGG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167577.1">
        <property type="nucleotide sequence ID" value="XM_009169313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGG1"/>
    <dbReference type="GeneID" id="20318731"/>
    <dbReference type="KEGG" id="ovi:T265_04549"/>
    <dbReference type="CTD" id="20318731"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705479" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8609" checksum="80E277345C50C59A" modified="2014-10-01" version="1">MSRAMWLWRGGLRLNLGLVFWRQGLVSGKNLFTANVWKKLSTCMDFWCITFTGGKVSYHFFAPSSTGTVYDPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI81</accession>
    <name>A0A075AI81_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165027.1">
        <property type="nucleotide sequence ID" value="XM_009166763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI81"/>
    <dbReference type="STRING" id="6198.A0A075AI81"/>
    <dbReference type="GeneID" id="20316688"/>
    <dbReference type="KEGG" id="ovi:T265_02500"/>
    <dbReference type="CTD" id="20316688"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="159"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="331" mass="36730" checksum="31420D6D82ED0D57" modified="2014-10-01" version="1">MLNPAIRSYTLLTCDSNVHCTGPPDLTDLERDQPTGGTYLGSGPAHEAALAVPAVMSADIIKSEDVPYPIPRSQRNNDGRITSVILLGASFFLFSALLIFMLLRLPSLPIDQQAALRFPKNVEDLKTLGSTLSEYQDSYYWEILIFISVTYIFLQSFMIPGSVLISILLGYLFPFPIALAIVALCSAVGATCCYLLVGFIGSQLLLHLIPKQIEQCRLLVSPSHHILPLQIQRHRHAMFFCICLLRICPLVPNWLVNVSSPIVEIPLLHFFWGTFVGVVPLSLVFVKAGTVLQELTDFGMTSLTSMYTLGFLAIASLLPFLFQKQIRQWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIK2</accession>
    <name>A0A075AIK2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164425.1">
        <property type="nucleotide sequence ID" value="XM_009166161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIK2"/>
    <dbReference type="GeneID" id="20316201"/>
    <dbReference type="KEGG" id="ovi:T265_02013"/>
    <dbReference type="CTD" id="20316201"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8215" checksum="00067A776272B5F1" modified="2014-10-01" version="1">MKINKVVDGEKEIEMLLVTAKCAEIPSVPGDVELQERPKIVSYFRPEPNEQVVLKKDLPPLEEDRIPPCMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJV1</accession>
    <name>A0A075AJV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162273.1">
        <property type="nucleotide sequence ID" value="XM_009164009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJV1"/>
    <dbReference type="GeneID" id="20326653"/>
    <dbReference type="KEGG" id="ovi:T265_12485"/>
    <dbReference type="CTD" id="20326653"/>
    <dbReference type="OrthoDB" id="6242194at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21478" checksum="97B55A03852A2773" modified="2014-10-01" version="1">MFAHKQAGQQAALARTLDSRSMLPVRIKDARRKFRLRNVEDAESAAARYAEGNIVFSDRAEASLLDWIPVDSRLSVVRLTTHHRTNANWNCAKNHLPHKSRTLRLATSGPRSQTKLPEPAPLKPAGQNGVGYKRPQGKHYPKCYSKPECLFAVQPSQPHPSIGSLIGPYLCWRPGDRFHLVASTAPPGASSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUU0</accession>
    <name>A0A074YUU0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR2 complex protein MIO zinc-ribbon like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599970">
        <property type="protein sequence ID" value="KER18546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177707.1">
        <property type="nucleotide sequence ID" value="XM_009179443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUU0"/>
    <dbReference type="STRING" id="6198.A0A074YUU0"/>
    <dbReference type="GeneID" id="20330154"/>
    <dbReference type="KEGG" id="ovi:T265_15989"/>
    <dbReference type="CTD" id="20330154"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="2">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="15957" checksum="1D9AD8FE8493BE08" modified="2014-10-01" version="1" fragment="single">VFVACGFCGWRLGPQNRPSLSSVGNPTSSTVTVQGTGTSPSDDTIATTTTTSSSRNLQMHGGGGKHTICQRCRKPLPRCSICLMHLGTVALPLTDSNWFTPTREEALKRSAIAAVPSLSENMARVMQLSIIGATGLEVMNNRGDDVKAHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW01</accession>
    <name>A0A074YW01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597438">
        <property type="protein sequence ID" value="KER18951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177302.1">
        <property type="nucleotide sequence ID" value="XM_009179038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW01"/>
    <dbReference type="GeneID" id="20329897"/>
    <dbReference type="KEGG" id="ovi:T265_15732"/>
    <dbReference type="CTD" id="20329897"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="16210" checksum="A4FF0E45AB8BCF34" modified="2014-10-01" version="1" fragment="single">KCLPSLRKFWGKARALPPFVLPNHNGEYFQNITGLQVTNPTFSTQVQMSWRSIIDSSPSGILKSDSNRSINARTSALATRLSQLDFESDTTRRHPRLNQVLWAFEWDKHVPLVSVYLESAKHITNSHMVDLRIASFLLPKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYM3</accession>
    <name>A0A074YYM3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane-bound transcription factor site-2 protease</fullName>
            <ecNumber evidence="3">3.4.24.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endopeptidase S2P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_12321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP) -1, SREBP-2 and forms of the transcriptional activator ATF6. SREBP-2 is cleaved at the site 477-DRSRILL-|-CVLTFLCLSFNPLTSLLQWGGA-505. The residues Asn-Pro, 11 residues distal to the site of cleavage in the membrane-spanning domain, are important for cleavage by S2P endopeptidase. Replacement of either of these residues does not prevent cleavage, but there is no cleavage if both of these residues are replaced.</text>
            <dbReference type="EC" id="3.4.24.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.85" evidence="3"/>
    <dbReference type="EMBL" id="KL604283">
        <property type="protein sequence ID" value="KER18292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177961.1">
        <property type="nucleotide sequence ID" value="XM_009179697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYM3"/>
    <dbReference type="STRING" id="6198.A0A074YYM3"/>
    <dbReference type="GeneID" id="20326489"/>
    <dbReference type="KEGG" id="ovi:T265_12321"/>
    <dbReference type="CTD" id="20326489"/>
    <dbReference type="OrthoDB" id="69989at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="11">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER18292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="16983" checksum="B7F02932D7A58C01" modified="2014-10-01" version="1">MPGVNLPISHVGFYMLTLLLCAFLHEAGHAMAALRERVRLHGFGVFLFGFYPGAYVDLNTADLQSLKPLGQLRVYCAGVWHNVIIAVLSAAVFYAIPLLLSPGYHIGTGVGVTFLREVSTDLQHIIHSFALCYPKCTSNPIVHYDASSAHNYPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYT3</accession>
    <name>A0A074YYT3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597114">
        <property type="protein sequence ID" value="KER19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176293.1">
        <property type="nucleotide sequence ID" value="XM_009178029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYT3"/>
    <dbReference type="GeneID" id="20325556"/>
    <dbReference type="KEGG" id="ovi:T265_11388"/>
    <dbReference type="CTD" id="20325556"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9304" checksum="61F1E1BB4A291B00" modified="2014-10-01" version="1">MNNEKTVRSSKAESEAAVILWKQQQARMSDMSVYGCEHSDVSKSFFFIFPHGVFLNEFVHKNGLRACRCLAKRSALRHEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ25</accession>
    <name>A0A074YZ25_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_11311</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KL597100">
        <property type="protein sequence ID" value="KER20046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176199.1">
        <property type="nucleotide sequence ID" value="XM_009177935.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YZ25"/>
    <dbReference type="GeneID" id="20325479"/>
    <dbReference type="KEGG" id="ovi:T265_11311"/>
    <dbReference type="CTD" id="20325479"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703833" description="guanylate cyclase" evidence="16">
        <location>
            <begin position="29"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="773"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1147"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER20046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1289" mass="145834" checksum="0365317900DF50E8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZY1</accession>
    <name>A0A074YZY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598057">
        <property type="protein sequence ID" value="KER18772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177481.1">
        <property type="nucleotide sequence ID" value="XM_009179217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZY1"/>
    <dbReference type="GeneID" id="20330000"/>
    <dbReference type="KEGG" id="ovi:T265_15835"/>
    <dbReference type="CTD" id="20330000"/>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="460" mass="50819" checksum="1BBF6DAFB92E6126" modified="2014-10-01" version="1" fragment="single">SVTEINILTIWTKPIPAHAPCFIGRFLELWIIELRLEHQMAEESFDSGVSSEHSQYTIEHKSCPDTVQKHNDLCADIWSPTSCGHNGEGYYGPKPAPYCSHIHSDSSLDHVKRSCLKRNYRQRSKPLLRSDQLASDTEPVGSVHSNPVQFIRRKAKAPGAQIQVFSDLASIKTMSSNPRDYPNGSIGPQRSSVYPEIAGSRGMESRVVHFAREQRDVGEKAVCERSLLPDITLDERIRLTDSRSRTSLPEYSRPPLIRNYSARDYVYLPSLQQNQMASSVPVLSRQQTLRSLLANQLDEHSEVLPSEPSIENRPRDSTYSAHVQVQPTSEVASGRTVLDRITSDMSSVTLGTDQERQQLLSALLSASKPTTSSSSQTSVLQSLLQRVNPQSGVGTSRPPAGQTSSSMPGQAFAQGQMKIQASGSAEDYANYQSLDAILGQMHAQPPPPAPCQPMDFRPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z197</accession>
    <name>A0A074Z197_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597026">
        <property type="protein sequence ID" value="KER20728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175515.1">
        <property type="nucleotide sequence ID" value="XM_009177251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z197"/>
    <dbReference type="STRING" id="6198.A0A074Z197"/>
    <dbReference type="GeneID" id="20324950"/>
    <dbReference type="KEGG" id="ovi:T265_10782"/>
    <dbReference type="CTD" id="20324950"/>
    <dbReference type="OrthoDB" id="10062329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="38306" checksum="7CCF4651507C1B27" modified="2014-10-01" version="1">MNFLTLSTLVHDKERAIRFLQSQGVFYQQRLCNNGRQMTLPTVPDRWRCNVQQCRQDIGLRKGTWLEGSRMDFRTVILFIYCCLKNLAKIKFCSEELSISHTTGVLTGRTFFVKFAPGGFCRLQQLSAGQVYTPRSMKRYYLAVKTWFQNRRMKHKKMKRGYVSSGQDTQQSLPLSGKRDGNPNYPATCGTNSSCSGTEDLEYERSRKVENFLCLPPSPTSSASASETYVNLEAVQSETWRAKRQIVLDTLRNPPSKKESKSLVVSSEADVSIPVKCRISEYESAQSGKDLMTSCGVTRDASEFDDIKSSVFNPKFLMQHYFLNCPISWGGVTKLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3P5</accession>
    <name>A0A074Z3P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596948">
        <property type="protein sequence ID" value="KER21686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174574.1">
        <property type="nucleotide sequence ID" value="XM_009176310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3P5"/>
    <dbReference type="GeneID" id="20324224"/>
    <dbReference type="KEGG" id="ovi:T265_10056"/>
    <dbReference type="CTD" id="20324224"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15759" checksum="8AECCEF7BAEE82D1" modified="2014-10-01" version="1">MVKTPPYIGLLLESESKSAKNVQMFIFLKKYRQLLANKLRKKKLLQQVENFEVSGYFSTAIPFEGTSPQNQRTYTARLNKRLIPPPPKKRSQWKRSNIEPDLLMNYHSEAWLTHYHITSMSFPDLAQREVCSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3P9</accession>
    <name>A0A074Z3P9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174559.1">
        <property type="nucleotide sequence ID" value="XM_009176295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3P9"/>
    <dbReference type="GeneID" id="20324209"/>
    <dbReference type="KEGG" id="ovi:T265_10041"/>
    <dbReference type="CTD" id="20324209"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20315" checksum="9BE22F6148C0B775" modified="2014-10-01" version="1">MPYPLRRETGMNSSVQNGMEHGVGEGGIFEFLFRQQNARQLGKCVLQNQVKSPAAGMSYPGAYLLLSVFFALLSNRRTIAVGGNPGDFADNCTPPRVISADRRPLSTRLQVLPPLFYSHWDAWRFPPPRPPVAVFAIRAFGDLEAMTHGIYGVGVALNPRTKRALVDWIPLVVFVPSGYLTQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4G0</accession>
    <name>A0A074Z4G0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597060">
        <property type="protein sequence ID" value="KER20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175848.1">
        <property type="nucleotide sequence ID" value="XM_009177584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4G0"/>
    <dbReference type="GeneID" id="20325208"/>
    <dbReference type="KEGG" id="ovi:T265_11040"/>
    <dbReference type="CTD" id="20325208"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13568" checksum="4811EE9EB2007F58" modified="2014-10-01" version="1">MSNKEKPNRGREPNGKGTGAKKSFVLSGRPSRIACHDFSAAVEQAHLDTISKNGTIGRIRIASFANLTGLEFSDPRQVDLSQAARSGKEGMCCNGGINFTSAGSPCMRQENHLGSDKENAKIPLHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z603</accession>
    <name>A0A074Z603_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598948">
        <property type="protein sequence ID" value="KER18650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177603.1">
        <property type="nucleotide sequence ID" value="XM_009179339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z603"/>
    <dbReference type="GeneID" id="20326371"/>
    <dbReference type="KEGG" id="ovi:T265_12203"/>
    <dbReference type="CTD" id="20326371"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6610" checksum="BA7F649D0C8A43E2" modified="2014-10-01" version="1" fragment="single">GRSEPTDTFDNPILSGRLAEFQFTSLSHFDNTSTDQENDNPRDGLDTNVVSPSHSVASADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6B5</accession>
    <name>A0A074Z6B5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596994">
        <property type="protein sequence ID" value="KER21102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175144.1">
        <property type="nucleotide sequence ID" value="XM_009176880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6B5"/>
    <dbReference type="STRING" id="6198.A0A074Z6B5"/>
    <dbReference type="GeneID" id="20324663"/>
    <dbReference type="KEGG" id="ovi:T265_10495"/>
    <dbReference type="CTD" id="20324663"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19871">
        <property type="entry name" value="DSRM_DUS2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044463">
        <property type="entry name" value="DUS2_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="422"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="501" mass="56056" checksum="9180DBB1A6DB81BD" modified="2014-10-01" version="1">MPHNIHADVECLNSLNTSYPQLAAVSADEQALAYQFLEWKVVKLDPSTVSGHVWSALKATSPFDPVGKVILGPMVRISTHPMRLLALRYGADYVFTEGTPDAERALRAAKMVYVKLLVYYLLYNVLFSRQDDVLAIDINMGCPKDYSIKGGMGAALLIQPEKVKEILTRLTSALRVPVTCKIRILPQLEKTLALVKLIESTGVAALTVHGRTPSERPRHRNHDEVIAAVASAVSIPVIANGGSWDTIRSHDDIEFFRQQTGAAGVMVCRSAMWNPAIFSPVCPAPTLHVLIREYLSLAVRYDHHIAGTKYCIQSMLHLEGETPLFLATLAAKDLKDLCRLYVFVNSHTWSVPDVYTVEMQRRAGIRDSASAKRVSTETVNEFGDAAKRPRINDDPEQLDQNGHVIRRNIPYERRYWPLHGTSPKQILYEYSNKTRIKAPEFHTTEDRESRLFFSTVLFDNKQFTNTSGCKSKKWSEQAAALVCLQFLGLSDGKCSETDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6F0</accession>
    <name>A0A074Z6F0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor ENY2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enhancer of yellow 2 transcription factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597841">
        <property type="protein sequence ID" value="KER18820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177433.1">
        <property type="nucleotide sequence ID" value="XM_009179169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6F0"/>
    <dbReference type="STRING" id="6198.A0A074Z6F0"/>
    <dbReference type="GeneID" id="20326310"/>
    <dbReference type="KEGG" id="ovi:T265_12142"/>
    <dbReference type="CTD" id="20326310"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11240" checksum="83C7DA1CE461B403" modified="2014-10-01" version="1">MSEKRAAIANKITDLLVKTGEKQRLLAFIEDRLIETGWNEKVKQACKDYIKSKGVDNINVEMVVQAITPSARQVIPSEVRQDVLDHLKRFLVQYDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6L7</accession>
    <name>A0A074Z6L7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596884">
        <property type="protein sequence ID" value="KER22703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173553.1">
        <property type="nucleotide sequence ID" value="XM_009175289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6L7"/>
    <dbReference type="STRING" id="6198.A0A074Z6L7"/>
    <dbReference type="GeneID" id="20323437"/>
    <dbReference type="KEGG" id="ovi:T265_09264"/>
    <dbReference type="CTD" id="20323437"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="1">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="390" mass="43538" checksum="20BE3332ACCDBAEF" modified="2014-10-01" version="1">MDFQILYVAYIRALLEYANQVVHSECTKGVISIERVQRSATRMFVGLKSEAYETRLAMLYLFPMEYRHLRGDLIRTCALFEQSLVNSSVVNEATLPTPATPDQPDTEELDPPKPLPLGACLFCDRQLTADMQNTCESGRNESLARRLLDHMSDAHHFVIPYPENLIDPAGLLTELGRIVGEERACLACGRQFYGRRFHSSSSQKPNSHVALNAVRQHMLDKPGHMRLWCGEDDPLQVALTIAKAEEAGETSPPPAALAGGELFSRFYDQSVVAPSFVLPDTEDGVYEVRLPSGTVLGHRNLASVYRQHLPPTPTDVTLVNQHALPSSRGTHVSRALVPSHIGPLCVRPQLHLPVKARADERHFEASRRAWELSTGIQGNLVLRAHLRRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6T8</accession>
    <name>A0A074Z6T8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_15126</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="EMBL" id="KL596979">
        <property type="protein sequence ID" value="KER21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174968.1">
        <property type="nucleotide sequence ID" value="XM_009176704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6T8"/>
    <dbReference type="STRING" id="6198.A0A074Z6T8"/>
    <dbReference type="GeneID" id="20329291"/>
    <dbReference type="KEGG" id="ovi:T265_15126"/>
    <dbReference type="CTD" id="20329291"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="15">
        <location>
            <begin position="100"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="597"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="644" mass="72164" checksum="99340A8B1236407C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z730</accession>
    <name>A0A074Z730_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596971">
        <property type="protein sequence ID" value="KER21382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174875.1">
        <property type="nucleotide sequence ID" value="XM_009176611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z730"/>
    <dbReference type="GeneID" id="20324454"/>
    <dbReference type="KEGG" id="ovi:T265_10286"/>
    <dbReference type="CTD" id="20324454"/>
    <dbReference type="OrthoDB" id="6281767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="394" mass="43884" checksum="0CB2C5213124A132" modified="2014-10-01" version="1">MRTQSSEHRATRGSAGRRRRKDFAQWKTIRQCAAANPGTCLTVDRGVQVKTNGICTTDPAEPKPHVDQFALIDQLKRTEEDVSQNKCPPSPTESIGPAEDDQLNKQEDEEIRELEAFALMSKQKRERQQVAHSSELPAATTDARCSPLDEENGSPSKDTPESTLAAPPRKYEPHTMAKETEIKVRKDVEEGKRNSGYFNKLVTTVRSTVCSDSTTIDKAKPDTIDVLGGPSSERTLGTPDKALSQRSSEAVCTSPPDYDIQLVSSSPYGKNYYHTLTHVGWSSHRRRECEPSQSPYVNAIDIQDLVGYRSNRLQGTEHYYNTMRPEPNHTFVTYTLNHRSNPTLSIHKAANVHPNVVQKPLIVASQHDALLSELLNRGSPMNVEAQRASIQSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z749</accession>
    <name>A0A074Z749_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596970">
        <property type="protein sequence ID" value="KER21402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174856.1">
        <property type="nucleotide sequence ID" value="XM_009176592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z749"/>
    <dbReference type="STRING" id="6198.A0A074Z749"/>
    <dbReference type="GeneID" id="20324440"/>
    <dbReference type="KEGG" id="ovi:T265_10272"/>
    <dbReference type="CTD" id="20324440"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20539">
        <property type="entry name" value="CYCLIN_CCNT_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="239"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="620" mass="69650" checksum="485A2A38EE238CC0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7F0</accession>
    <name>A0A074Z7F0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596868">
        <property type="protein sequence ID" value="KER23033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173235.1">
        <property type="nucleotide sequence ID" value="XM_009174971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7F0"/>
    <dbReference type="GeneID" id="20328894"/>
    <dbReference type="KEGG" id="ovi:T265_14728"/>
    <dbReference type="CTD" id="20328894"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26542" checksum="68AC098E70113D45" modified="2014-10-01" version="1" fragment="single">LEFVVISKAFDSVSHVTIDRSAEAFGAPSPHVRNAAQSCENAGEVFQNSEVHSQRGVRQGDNLPLLFIMTMDDVSELSMPQLRKQFHDMLSDVLTFPDELVDSQPDYSPKNDLRFPQTECHSMDPIYALLRAKTNISTGSLKKDRILDSQTTKRGTPRSEINKGHKPDLRRTKVTPKSTRLRRRGMRSLNVTTATANEDTGFWWMRDFVECTYTHIHDSRLNGRLPVLKQPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Q5</accession>
    <name>A0A074Z7Q5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597268">
        <property type="protein sequence ID" value="KER19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176998.1">
        <property type="nucleotide sequence ID" value="XM_009178734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Q5"/>
    <dbReference type="GeneID" id="20326078"/>
    <dbReference type="KEGG" id="ovi:T265_11910"/>
    <dbReference type="CTD" id="20326078"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8642" checksum="204772F3A7C49E3A" modified="2014-10-01" version="1">MSTSKKLGPDFGAPSGEDTRQRCGELRWTTTSDSHFAQTSTLFDHTNHPTHFQGVSFPVFEKPVIDSPTKHHLATVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7S5</accession>
    <name>A0A074Z7S5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173023.1">
        <property type="nucleotide sequence ID" value="XM_009174759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7S5"/>
    <dbReference type="STRING" id="6198.A0A074Z7S5"/>
    <dbReference type="GeneID" id="20323026"/>
    <dbReference type="KEGG" id="ovi:T265_08847"/>
    <dbReference type="CTD" id="20323026"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33525" checksum="53A152C344779011" modified="2014-10-01" version="1">MTEPEVRSHLWVKMRKILRELYHVADDYDYFYKADDDTYAFVSNLRQFLAAEDEPSEPVMWGYRWMAKRLSFRRPYVLLGPKLHDISKIHSFPNKFCFVGDSPGTQVNLSFMFRTSGSEKDIVTRCFLELCSDITPQAISFFIKTLFSTFTQQRLCPGGYFSGGSGYVLTREALKRIVERAIDRHPDCPTTDEDKEDVKMCLCGRAVGVRLEDGRLENGRDLFYPYSAKTMAQENMKTLYFGLWGSDPKSSVLDFDPSHISFHYIENNEMYIFEFLTYYLRPIEFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W3</accession>
    <name>A0A074Z8W3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7083 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172674.1">
        <property type="nucleotide sequence ID" value="XM_009174410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8W3"/>
    <dbReference type="GeneID" id="20322744"/>
    <dbReference type="KEGG" id="ovi:T265_08565"/>
    <dbReference type="CTD" id="20322744"/>
    <dbReference type="OrthoDB" id="6242354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7083" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8116" checksum="1437F04FB0B15024" modified="2014-10-01" version="1">MNATGRHENAQLSQQNDCGRQTYHENFVNQIANSITEFHYDLDAGRTFDSWFRRYEDIFAVELKNKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAB6</accession>
    <name>A0A074ZAB6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_08095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596819">
        <property type="protein sequence ID" value="KER24206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172058.1">
        <property type="nucleotide sequence ID" value="XM_009173794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAB6"/>
    <dbReference type="STRING" id="6198.A0A074ZAB6"/>
    <dbReference type="GeneID" id="20322274"/>
    <dbReference type="KEGG" id="ovi:T265_08095"/>
    <dbReference type="CTD" id="20322274"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901379">
        <property type="term" value="P:regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22803" checksum="7988E17A520AF6F4" modified="2014-10-01" version="1">MSAERTLGKILKNKNWRRSSYVISTRLSRSGDAVTEQGISRKRLVEGLRGSLDRLQLEYVDIIIVTRQPDTQIPIEDVVRTCTHLIELGWAFYWGTCKWTPAEIMGHQALLEHILSPKGRMHQTQVRQLCKLASRLHCTCAQLAIAWCLKTPTLSCVLLGAATVDQLQENLEAIQVQTRINFTVQSEIERILSTDSSDNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAZ6</accession>
    <name>A0A074ZAZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596884">
        <property type="protein sequence ID" value="KER22707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173557.1">
        <property type="nucleotide sequence ID" value="XM_009175293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAZ6"/>
    <dbReference type="GeneID" id="20323441"/>
    <dbReference type="KEGG" id="ovi:T265_09268"/>
    <dbReference type="CTD" id="20323441"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10730" checksum="9BC59729738ECB8C" modified="2014-10-01" version="1">MTKCARILANRMRLARKLAIKPLLNLVEPVERLPVSRVCVVAQPIVRVKVLSKICVEEDTCLHLLEFGGAGTNVSVLNSADTPCVLRLRLPVFRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBK9</accession>
    <name>A0A074ZBK9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171610.1">
        <property type="nucleotide sequence ID" value="XM_009173346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBK9"/>
    <dbReference type="GeneID" id="20321926"/>
    <dbReference type="KEGG" id="ovi:T265_07747"/>
    <dbReference type="CTD" id="20321926"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF378">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="422" mass="48920" checksum="AF5BC0E19017C2BA" modified="2014-10-01" version="1">MKTRVFFVVGRRLQNRTADEIMLKHEHMKFRDIALLAIQLSDCAVDSTVRFPTRENAIVNFLFQIRLLSRPTSKRWLLYVILPYIFLISNIIPKHIQSTPPSLPFVRQTDFYPAFEQYKNNQVVYTVPQRRWRNKLKVPMENAKLCKPTPELLLVVMVNESERTLRDNIRMTWGNASHFSECGLPARFVFAFGVGPIHLNSMSKDQLTDELTEHRDFIQFDYLESKWTNRGTQKVAAILNRLTKRCSSSRFIAIVDEDFVVNPRNLVRELHAVTAIQYPIHISGFTLNNTPVDIVVKRDRSLHHEVLVHTMIPRFVVRGFILMSMPVAKLLAFGMSLMPYISEFDRAIGAILLNFRISPTYMNGIHIHGNTRKLGSDQLIRLVVWHEHSDFGSWHNRWNSLAKPCNNVTPYAKSTSGNNTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBV0</accession>
    <name>A0A074ZBV0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171498.1">
        <property type="nucleotide sequence ID" value="XM_009173234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBV0"/>
    <dbReference type="STRING" id="6198.A0A074ZBV0"/>
    <dbReference type="GeneID" id="20321840"/>
    <dbReference type="KEGG" id="ovi:T265_07661"/>
    <dbReference type="CTD" id="20321840"/>
    <dbReference type="OrthoDB" id="6283029at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="200" mass="22189" checksum="3455D5A1A04A1338" modified="2014-10-01" version="1">MKTFTSIGEWEQFKEIVKNFTYLGSCISSDGSVSGEVSARISKARITFSNLRHLWRQQGISLDLKGRVHQATVRAVLLYGCDTWPLRVDDVRPPVSIGVPQGSVLGPLLILIYINDLPDVLASPCLLFADDLKSWSSNASALKMDVDAAKQWSLDWHLPLNDKKCIHMSFGGDSANAFVMHGEKEPENIMRTDAKKDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBW4</accession>
    <name>A0A074ZBW4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_10825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597031">
        <property type="protein sequence ID" value="KER20680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175568.1">
        <property type="nucleotide sequence ID" value="XM_009177304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBW4"/>
    <dbReference type="STRING" id="6198.A0A074ZBW4"/>
    <dbReference type="GeneID" id="20324993"/>
    <dbReference type="KEGG" id="ovi:T265_10825"/>
    <dbReference type="CTD" id="20324993"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="152"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="299"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="445"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="594"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="740"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="889"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="132317" checksum="60E0AC23FDD6202C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC15</accession>
    <name>A0A074ZC15_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MAS20 protein import receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171615.1">
        <property type="nucleotide sequence ID" value="XM_009173351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC15"/>
    <dbReference type="STRING" id="6198.A0A074ZC15"/>
    <dbReference type="GeneID" id="20321931"/>
    <dbReference type="KEGG" id="ovi:T265_07752"/>
    <dbReference type="CTD" id="20321931"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022422">
        <property type="entry name" value="MAS20_rcpt_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01989">
        <property type="entry name" value="EUOM20RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16638" checksum="CC4DFB40B330FF4A" modified="2014-10-01" version="1">MREILPVVAAGAGLCFLGYCIYFDRKRRSAPGFRENLMKKRRQQALDAQRACSLPIPPLGDPGAMHKFFLEQIQQGELALSMGSVEEGVQHFAVAVTVCGQPTQLLQVLQQSLSPSVFTMLIEALPSVRNQIFGMSTLRTSGAKEVEEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCP5</accession>
    <name>A0A074ZCP5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171237.1">
        <property type="nucleotide sequence ID" value="XM_009172973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCP5"/>
    <dbReference type="GeneID" id="20328462"/>
    <dbReference type="KEGG" id="ovi:T265_14296"/>
    <dbReference type="CTD" id="20328462"/>
    <dbReference type="OrthoDB" id="10670964at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="306" mass="34975" checksum="6A9025A81A7299FC" modified="2014-10-01" version="1" fragment="single">NNLDTVVEVPDTEHFVTREFDDPEYQKEKLDTKFYGTIYTKSSKCIQQTSIVRVLCISKSVARFEIPDNGQRNIGLMVPSWSSHVILIGGATTRKSRRHKSDQAPTGRVRMHTYMSVTDTHEYQCDGDTADGWHASRYMFNILFSAYGRNNLDTVVEVPNTEHFVTREFDDPEYQKEKLDTKFYGTFTQKSSKCIQQTSIVRVLCISKSVARFEIPDNGQRNIGLMVPSWSSHVILIGGATTRKSRRHKSDQAPTGRVRMHTYMSVTDTHEYQCDGDTADGWHASNRLLRTSENKLVQSTKLSNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD2</accession>
    <name>A0A074ZDD2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170906.1">
        <property type="nucleotide sequence ID" value="XM_009172642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD2"/>
    <dbReference type="GeneID" id="20321365"/>
    <dbReference type="KEGG" id="ovi:T265_07186"/>
    <dbReference type="CTD" id="20321365"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="9104" checksum="4E042DDB02FFBF8B" modified="2014-10-01" version="1">MDPANYMCVMPKMPKQQTNSVKLWRLPYQHKSSNNEENQSQAVLDRETGMESFKQDGLRKSISRIFGQTLINALERGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDP4</accession>
    <name>A0A074ZDP4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170858.1">
        <property type="nucleotide sequence ID" value="XM_009172594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDP4"/>
    <dbReference type="STRING" id="6198.A0A074ZDP4"/>
    <dbReference type="GeneID" id="20321329"/>
    <dbReference type="KEGG" id="ovi:T265_07150"/>
    <dbReference type="CTD" id="20321329"/>
    <dbReference type="OrthoDB" id="6278202at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11397" checksum="344287875C48068D" modified="2014-10-01" version="1">MCSLLRFGTLRFSQPLSTTQQTGVSCSSHYYLPFIPHTQGPQAMLDDMNTLIDSLKKRTLELEKQLSASYADVDRISLDLCKLRSRLLEDGVIKYLERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDT9</accession>
    <name>A0A074ZDT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596834">
        <property type="protein sequence ID" value="KER23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172444.1">
        <property type="nucleotide sequence ID" value="XM_009174180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDT9"/>
    <dbReference type="GeneID" id="20322565"/>
    <dbReference type="KEGG" id="ovi:T265_08386"/>
    <dbReference type="CTD" id="20322565"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9415" checksum="55CD242EE0DCE420" modified="2014-10-01" version="1">MSDDQLPQDFSRLLTKETDIMDLKMTKFSCLKYLLELNEHSDLLADSVGVQQHQSEYRYMRKPATTSLLHFKVIQHNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZED9</accession>
    <name>A0A074ZED9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596770">
        <property type="protein sequence ID" value="KER25636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170594.1">
        <property type="nucleotide sequence ID" value="XM_009172330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZED9"/>
    <dbReference type="GeneID" id="20321106"/>
    <dbReference type="KEGG" id="ovi:T265_06927"/>
    <dbReference type="CTD" id="20321106"/>
    <dbReference type="OrthoDB" id="10532156at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="17925" checksum="F619989321F79533" modified="2014-10-01" version="1">MDAINETCTTHKAQSPSFRQPHVLLESKLHELSEIGSFASKYGFDGKPTWIPAESLVCDVSRQLNVLHQVASCPSRYDIRDITIHIYPKCTTHKAQSLLGRNPRGSHALLRLRSLARSRLAQNSGRLPVRHQDEISLVNNLDQTANHDPVLAKCRLPMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEG9</accession>
    <name>A0A074ZEG9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170658.1">
        <property type="nucleotide sequence ID" value="XM_009172394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEG9"/>
    <dbReference type="STRING" id="6198.A0A074ZEG9"/>
    <dbReference type="GeneID" id="20321156"/>
    <dbReference type="KEGG" id="ovi:T265_06977"/>
    <dbReference type="CTD" id="20321156"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="349" mass="38917" checksum="F39EE72180E85844" modified="2014-10-01" version="1">MKIPQTPNNQELKDDGNDDSDDNDGEKENELNSVIFLTMEVAFELAMEALDAGEVPVGCVFIRDGTIIAKGRNEVNATKCAIEHAEMVAIRRLEQWCIQHQLSLADTLRDSELYVTVEPCIMCASALRFCLPAHPKRIIYGAKNERFGGCGSVFSIHDSDSATTPPLICVSGIQEDRAVSLLKQFYTQENPNAPPELRKSKPCLKNTGSIKVKYRGSAITEVEIAQWLRRELTDRKVPTGAQPPHLECSCLGLGSLVVSRPLYLLHVAWYLGTEMVLQLDSIAARKLIASFVLHHTRQQHLLVRQTPRDEFSNRLRLSGDAGATEYAGFGTVQCYQALTWYLRLCAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEP8</accession>
    <name>A0A074ZEP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172106.1">
        <property type="nucleotide sequence ID" value="XM_009173842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEP8"/>
    <dbReference type="STRING" id="6198.A0A074ZEP8"/>
    <dbReference type="GeneID" id="20322308"/>
    <dbReference type="KEGG" id="ovi:T265_08129"/>
    <dbReference type="CTD" id="20322308"/>
    <dbReference type="OrthoDB" id="419617at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="1">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="24455" checksum="30E2A446AE5AF830" modified="2014-10-01" version="1">MPSSILTRKKLQCYLQDVGTFSNPKLQLEQYPTSAQVATDILFNMQTVDGALQGMSVADLGCGPGVFSIGACLLGASYVLAVDVDADALNDLSENLDAHDLKHGCIDIMLADVTRLSRDDGRKLVDTVILNPPFGTLASNTGIDMKFLNAALSMAQSHVYSLHKSTTRSLSFGSLCSPQHVLRTAEATGAKAKVVAELRFDIPRMYKRHKQNTVDIQVDLVHAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF38</accession>
    <name>A0A074ZF38_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170466.1">
        <property type="nucleotide sequence ID" value="XM_009172202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF38"/>
    <dbReference type="GeneID" id="20321007"/>
    <dbReference type="KEGG" id="ovi:T265_06828"/>
    <dbReference type="CTD" id="20321007"/>
    <dbReference type="OrthoDB" id="6253237at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="ovi:T265_14021"/>
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        </location>
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    <feature type="non-terminal residue" evidence="2">
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            <position position="1"/>
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</entry>
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                <person name="Nagarajan N."/>
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                <person name="Korhonen P.K."/>
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                <person name="Yang X."/>
                <person name="Hu M."/>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2947" mass="316130" checksum="163B867F974D5C32" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHT0</accession>
    <name>A0A074ZHT0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169423.1">
        <property type="nucleotide sequence ID" value="XM_009171159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHT0"/>
    <dbReference type="GeneID" id="20328085"/>
    <dbReference type="KEGG" id="ovi:T265_13918"/>
    <dbReference type="CTD" id="20328085"/>
    <dbReference type="OrthoDB" id="6265721at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="360" mass="40848" checksum="361E968AC6128F71" modified="2014-10-01" version="1" fragment="single">LVIHKYDFSSVCVRTALQTGSPSFFWVRPSRSAFRVKMEAPIPKLASNKSVGTLTEDITENQIKTPCTTPAGETADGDYFTCHEQNPNSVSSDVPVGPYLSDENENWEPDLPCAESLATSIIYGDTDQYKIIGRNHHITDDSTTLQVLVRALKQPTLEESVHVQAPSKVSCLPKKVADEESIQFTSSTSLVTDDYEKNQEPVKAEVHVHRRKKLEWKLQPNSEPLTSEPRPRGSRNSWTVYDDLLEDLEDSLCPVESHTHDRSSTGLDPSESFNGLDLPASKRMYEIIEDYLQRKFLNFSGRLDRDTDYTRSTKICAEIATMTDAEERDDDEEESWFANRRSQCLPMCRCVPKRTISKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHW0</accession>
    <name>A0A074ZHW0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_09141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173402.1">
        <property type="nucleotide sequence ID" value="XM_009175138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHW0"/>
    <dbReference type="STRING" id="6198.A0A074ZHW0"/>
    <dbReference type="GeneID" id="20323320"/>
    <dbReference type="KEGG" id="ovi:T265_09141"/>
    <dbReference type="CTD" id="20323320"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="485"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7 8">
        <location>
            <position position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER22870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="819" mass="93761" checksum="DBB1852078B8492A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI41</accession>
    <name>A0A074ZI41_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dendritic cell-specific transmembrane protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169279.1">
        <property type="nucleotide sequence ID" value="XM_009171015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI41"/>
    <dbReference type="STRING" id="6198.A0A074ZI41"/>
    <dbReference type="GeneID" id="20320068"/>
    <dbReference type="KEGG" id="ovi:T265_05886"/>
    <dbReference type="CTD" id="20320068"/>
    <dbReference type="OrthoDB" id="6598372at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="496"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER26978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="900" mass="102673" checksum="BF2745C46A7F44BD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIB7</accession>
    <name>A0A074ZIB7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_07001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170686.1">
        <property type="nucleotide sequence ID" value="XM_009172422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIB7"/>
    <dbReference type="STRING" id="6198.A0A074ZIB7"/>
    <dbReference type="GeneID" id="20321180"/>
    <dbReference type="KEGG" id="ovi:T265_07001"/>
    <dbReference type="CTD" id="20321180"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER25542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="756" mass="86377" checksum="602F5469E644C4A1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIP6</accession>
    <name>A0A074ZIP6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173077.1">
        <property type="nucleotide sequence ID" value="XM_009174813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIP6"/>
    <dbReference type="GeneID" id="20328860"/>
    <dbReference type="KEGG" id="ovi:T265_14694"/>
    <dbReference type="CTD" id="20328860"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8996" checksum="285F69F0C6D60A33" modified="2014-10-01" version="1" fragment="single">EEEVRQISEERRSLIAQNSALAYKLRKSAQLVSENEYLDQVLLRVQTIVKRIKHEHLMLRSEMDQLLQASRPPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJD5</accession>
    <name>A0A074ZJD5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172771.1">
        <property type="nucleotide sequence ID" value="XM_009174507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJD5"/>
    <dbReference type="GeneID" id="20322820"/>
    <dbReference type="KEGG" id="ovi:T265_08641"/>
    <dbReference type="CTD" id="20322820"/>
    <dbReference type="OrthoDB" id="10585320at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13962" checksum="BED1F16E7DF499D4" modified="2014-10-01" version="1">MDCYNFNRTCQFPTPEIILRSTLTNHEDCSQLSQPIANAIQSQILHSPEASIKCKAHAKRWYDGGQFIQQGLCFAKVFKDEGDVICVLQIDKALASNNLDTGVLKAIQCSLYYFIDDEVEQELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLL3</accession>
    <name>A0A074ZLL3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171995.1">
        <property type="nucleotide sequence ID" value="XM_009173731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLL3"/>
    <dbReference type="STRING" id="6198.A0A074ZLL3"/>
    <dbReference type="GeneID" id="20322216"/>
    <dbReference type="KEGG" id="ovi:T265_08037"/>
    <dbReference type="CTD" id="20322216"/>
    <dbReference type="OrthoDB" id="19903at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="38626" checksum="73951F98A9C72EB4" modified="2014-10-01" version="1">MVGLTSFYLYSITILFSNFRLSACDNCEQCQKIVSAFSAGLDRTATKGFSGGNTHWEQRNIGSYATSEIRFDDIIAGVCVKSDYKCHEILGVLEPLIYDWWNDVFKINQSKILEFGDYLCLTEAKYCCPAGHFGPACNVCSPCVIQGGSCDGNGTRGGSGKCICREGYVGEACNRCNSKTHYSLPSENGDADICLNCHASCLGGCRGPDPSDCTGCAAGWTWIEEEESQAACKDVDECQHDPCERSTEYCLNTAGSYECHRCSVSCDGCHGPSAHDCARCRQGYHLVDGKCEDVDECSRKPSPCQGDGETCRNTPGSYVCECYPHLERRDGRCTAKQSGNANDNAGAVTLSRGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLL7</accession>
    <name>A0A074ZLL7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172000.1">
        <property type="nucleotide sequence ID" value="XM_009173736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLL7"/>
    <dbReference type="GeneID" id="20322221"/>
    <dbReference type="KEGG" id="ovi:T265_08042"/>
    <dbReference type="CTD" id="20322221"/>
    <dbReference type="OrthoDB" id="6227550at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21737" checksum="4985DC0BDC265356" modified="2014-10-01" version="1">MMGNFKNAALRQTTLYKPKTTEIFAHIYQTLLLSIPSLSLYLSARSCSLLILTALSSISMNIPVPYQAKDSANVGSAGVPARKMIHSSMNCHIPVEEEPGDRTEVLYGNMDKGLQARVIRHVNKYWDHKNPMPSIYPILLKLEREIGPGWRVDKIQNEQHVRADAVVKSTVNFKVSPDPTMYSIWRQQVPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLV1</accession>
    <name>A0A074ZLV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171920.1">
        <property type="nucleotide sequence ID" value="XM_009173656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLV1"/>
    <dbReference type="GeneID" id="20322158"/>
    <dbReference type="KEGG" id="ovi:T265_07979"/>
    <dbReference type="CTD" id="20322158"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="49564" checksum="D1F95926555D70D3" modified="2014-10-01" version="1">MALVHRELSLSWLTNHQKRSTLRHRGPDCTSFSRRLCDPKMAMKYSQPGLDCKSRTPVCLTGFIRNWSIILNNIRLMETRGLRLPDEPQKGRNHSWVVDEFSAPLELLTRLPKTLQRPTTGFAFLEAHQPIDKYTHLQIDLVFTRDSTESLVYDVLQMNVLHIGTIFEISHYIFIKKTTYKRARWPKWLEREFADRKVRGSNPTSASRIPLSLLGQPDSIPALVQPSGGMAVRHQNGATVERCFYPSLDGSSPDAEVGFVPLTFGSISSRLNHVSHEEYYCQHFFRKDLVLVFGLSSTENKFVVRTRPLPLEIPYLGLGDLVVSQPSCLLRVAWQLGTERVLQLDEVTWISFPYTTYRQTTECAALGHLIFQSLRYSRYHDACILFKPKLMIFEKYTHLQINLVFMRDSTESLVYAVLQLNALHTGRRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM00</accession>
    <name>A0A074ZM00_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171835.1">
        <property type="nucleotide sequence ID" value="XM_009173571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM00"/>
    <dbReference type="GeneID" id="20322090"/>
    <dbReference type="KEGG" id="ovi:T265_07911"/>
    <dbReference type="CTD" id="20322090"/>
    <dbReference type="OrthoDB" id="10506181at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="18127" checksum="5250B81EBEA5726A" modified="2014-10-01" version="1">MCHTRHRSSQLTTHLRAERSHKVQSENRVVSSQYIINWHGKSVKKLSSGVTTRKINITDSPTDFEKRALYRNSSERRPQNLENNTLKARTELACFIIEAFLEFYLVARFVEWRHSRWNILDESTAKGGEALDSSSALTGAHQQCISLALPGSELRTPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM32</accession>
    <name>A0A074ZM32_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596810">
        <property type="protein sequence ID" value="KER24430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171827.1">
        <property type="nucleotide sequence ID" value="XM_009173563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM32"/>
    <dbReference type="STRING" id="6198.A0A074ZM32"/>
    <dbReference type="GeneID" id="20328591"/>
    <dbReference type="KEGG" id="ovi:T265_14425"/>
    <dbReference type="CTD" id="20328591"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="156"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="545" mass="61546" checksum="F0B5A913707D4AB0" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMI3</accession>
    <name>A0A074ZMI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">T265_07800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596805">
        <property type="protein sequence ID" value="KER24570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171684.1">
        <property type="nucleotide sequence ID" value="XM_009173420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMI3"/>
    <dbReference type="STRING" id="6198.A0A074ZMI3"/>
    <dbReference type="GeneID" id="20321979"/>
    <dbReference type="KEGG" id="ovi:T265_07800"/>
    <dbReference type="CTD" id="20321979"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="400" mass="46262" checksum="30A864DE4C113718" modified="2014-10-01" version="1">MNPDSVLRIGKVFYTPYGGEGVDFVDQLNYQFTGGLLIIFIAVIGIRQYVGKPIQCWVPQEFTHSWEEYAENLCWVQNTYFLHPSDNVPEDDYELTKVKHIGYYQWIAIVLAGQVMLSWVPYLLWRVGSKRLPILLRSAKEASVPDRELRQKAISCLVATLEEQAESTARYRRMTSGLKRFLCQLRPNTRITFLFFIVRFCFIGNSVGQIYLMKHFIGTNSTMFGVEVLNDIVSGKDWETSGKFPRVTFCTVRVRKMGQIKPASYTLQCVLPINYFVEKVYVFLWFWFVILTCITLLSTIHWAFNTLLPVRRIAYIKQYIRAIRQLSNTEERDCTRFVNNNLGPDGVLILQVVSRVSSDLIALDVTATLWSNYRHAKITGTEEDINRFLETVNRNSTTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN11</accession>
    <name>A0A074ZN11_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167709.1">
        <property type="nucleotide sequence ID" value="XM_009169445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN11"/>
    <dbReference type="GeneID" id="20318836"/>
    <dbReference type="KEGG" id="ovi:T265_04654"/>
    <dbReference type="CTD" id="20318836"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="15564" checksum="EF032A4C1446B9AB" modified="2014-10-01" version="1">MTGQKLDLRSLSIPCINPGIGVSVAPYPRLPSTRISYLPLKFPYLLALSILSLPDPNTSFECSVTDEVSGRTCNAQVAFANLKHLWRQGGYPLQYGLLCCLADTWPVWEAETGRFQVLDNACLKAVGRVVWCLQIHQVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNK8</accession>
    <name>A0A074ZNK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168855.1">
        <property type="nucleotide sequence ID" value="XM_009170591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNK8"/>
    <dbReference type="GeneID" id="20319732"/>
    <dbReference type="KEGG" id="ovi:T265_05550"/>
    <dbReference type="CTD" id="20319732"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="10766" checksum="0C49C44C0E9CD41F" modified="2014-10-01" version="1">MMIEAEKDLGIWVSSNLTFPRNTRRENTPAKLSTQDARKTSPSLSVPSEAPREVLLASNSWTTKRISRCSISFPWSTCPPSGCRRCQAVVVGLAPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP75</accession>
    <name>A0A074ZP75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171120.1">
        <property type="nucleotide sequence ID" value="XM_009172856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP75"/>
    <dbReference type="STRING" id="6198.A0A074ZP75"/>
    <dbReference type="GeneID" id="20321536"/>
    <dbReference type="KEGG" id="ovi:T265_07357"/>
    <dbReference type="CTD" id="20321536"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="18117" checksum="DD8C3C30D7DAB2C0" modified="2014-10-01" version="1">MQDGRQLVGTFKAFDRHMNLVLCDCDEFRHVKVKGSKQEKEKQEKRALGLVLLRGEHVVSVNVDGPPPPEDTARVPLPGAGAWAGAGIKPMAGVAVGRGMPLATPAAAIPPPAPPAGLAAPVWGVGAPAPGLMQPRVAAGMPPPPPPPTAAHPGAAVAFGRGMPPVAGRGFPPAPGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPK9</accession>
    <name>A0A074ZPK9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166896.1">
        <property type="nucleotide sequence ID" value="XM_009168632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPK9"/>
    <dbReference type="GeneID" id="20318200"/>
    <dbReference type="KEGG" id="ovi:T265_04014"/>
    <dbReference type="CTD" id="20318200"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16046" checksum="D560B6C207A8F210" modified="2014-10-01" version="1">MLRCYPYCYIGQEPGRCAPRTSKDFQCLTVNVFKAIYRFHAVHAVPPLVCDALNSVWGMSRSQISMRSAGPTKHNLCRLLPHHPKEARGLNYCQLSQAWTGKSKGIGRVRTTDLPVGVRKPLPANSAALVTAVFLDGDPETGHVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ73</accession>
    <name>A0A074ZQ73_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166985.1">
        <property type="nucleotide sequence ID" value="XM_009168721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ73"/>
    <dbReference type="GeneID" id="20318261"/>
    <dbReference type="KEGG" id="ovi:T265_04075"/>
    <dbReference type="CTD" id="20318261"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21527" checksum="AAFD159C6E0989EE" modified="2014-10-01" version="1">MDGRSRQADCLTSPGLLKRLRQFVDKHFNTVSAASEGIAHHLRRYALFRALSSTANPQSCFILTGEDTEGGMFTGHRGVNITFEMLEDVGAGCCANVACKTDVGCMESSVLNAEPTKGKLLVELREGEENQRAWNQFEITQRDDGKRGMWPQTKLRTLVDSNPNRRVIEESPTTELGSFPDKPRQKINPGTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQX9</accession>
    <name>A0A074ZQX9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166414.1">
        <property type="nucleotide sequence ID" value="XM_009168150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQX9"/>
    <dbReference type="GeneID" id="20317802"/>
    <dbReference type="KEGG" id="ovi:T265_03615"/>
    <dbReference type="CTD" id="20317802"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="182" mass="20450" checksum="806E745CEF1442D9" modified="2014-10-01" version="1">MEHRRRSKPTASSLRDMDVEHSASQAVVDSKFHAVLNSKKERKRKRSPVAPFRCLAAMPPEGSKRAVILPSRPSLDTESRVAEVGFEPRTSRSENSTPTTWAISHIPPSLLNICSHISSRPVHKTTFITPGQLEILKFNISAPDECERRVAVVVGLLAFSKWRKAHPYVIRRGLSIHLRRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT32</accession>
    <name>A0A074ZT32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601517">
        <property type="protein sequence ID" value="KER18424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177829.1">
        <property type="nucleotide sequence ID" value="XM_009179565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT32"/>
    <dbReference type="STRING" id="6198.A0A074ZT32"/>
    <dbReference type="GeneID" id="20326446"/>
    <dbReference type="KEGG" id="ovi:T265_12278"/>
    <dbReference type="CTD" id="20326446"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19275" checksum="5737F7521C389C74" modified="2014-10-01" version="1">MHLSFFCEPDRSNFRLGSLSHLLNRHQWHYRDLPDWPAIPPDPWSRVVKTTPDGTSTVNSESHSPASAIRTSASGGKPGNLVSYDDFFSESDGSTTEDDADGVADDLVEEKIKENKDLLVCWINFVNPTFFFTRSFNCVIIHALVGLLPIVKELNPSVILAAFGVQFHNTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTB6</accession>
    <name>A0A074ZTB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165640.1">
        <property type="nucleotide sequence ID" value="XM_009167376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTB6"/>
    <dbReference type="GeneID" id="20317185"/>
    <dbReference type="KEGG" id="ovi:T265_02997"/>
    <dbReference type="CTD" id="20317185"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9876" checksum="46E900A2A164EE13" modified="2014-10-01" version="1">MLECSFEDYSQVEFVNLFPDEQDDSSNGSNVERSSEEVFIPSWVEFTPQVDINLSTGPSSHISQPDSPHSVEQENQSERKQPAPVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTU3</accession>
    <name>A0A074ZTU3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165292.1">
        <property type="nucleotide sequence ID" value="XM_009167028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTU3"/>
    <dbReference type="GeneID" id="20316901"/>
    <dbReference type="KEGG" id="ovi:T265_02713"/>
    <dbReference type="CTD" id="20316901"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19517" checksum="10E336F74CF47337" modified="2014-10-01" version="1">MDKKREHYKESVYENSVFDYHHCLRSSVWDWREHQTSNTPDGFGKRLGQPGSIPDLVLTSSGMAVRHQEGATVSLDMPNLAENPAKYQYKPHTTVEKEARQNWNERLNRKLSTYVAYETRIQDPSSVTHFKSLDTNPGFSHFTLLMPGYHDAIARATTYGVEVVLSSRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW7</accession>
    <name>A0A074ZTW7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165693.1">
        <property type="nucleotide sequence ID" value="XM_009167429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW7"/>
    <dbReference type="STRING" id="6198.A0A074ZTW7"/>
    <dbReference type="GeneID" id="20317227"/>
    <dbReference type="KEGG" id="ovi:T265_03040"/>
    <dbReference type="CTD" id="20317227"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF35">
        <property type="entry name" value="NUCLEOTIDE EXCHANGE FACTOR SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="420" mass="48045" checksum="5CFE91635DEDB870" modified="2014-10-01" version="1">MDPEERTSENLPSLISRTDNTSVSSVAGNDSSSSKSDSNPFLLPYIEEELDESHIQRIKSKFRSYEELKADFQKINAQVKMDFEILMEIMESLNKSDIPDERLPFLLEDLSYLLHQVRFLFILLNSDQVDNGRLFSENEGFNLLRRFMTHPNITIQKQVLSTMSAAIQGNSDVKIVALQSGLLDMLCLKLRNCTDSTYPPDESVTLIASVLTTLSALLRDFPSAQKYFFSTDRAIQPLQAGFDLLATLFDYKVDGEELRNKMSRIRIQLHLFVSDLVLERTNAKQRASLPSEQHNKRLVKLYSETEFETALVRSGWCDRLYHSLLHDMPKGVSADRVNTVSTHGPRQELLSATLHLHPFCDKVQPEVYSLLQEFEQEYAAYLALPENKNDLFYQDMLNLVVGVRKLFDESLASRRAADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU20</accession>
    <name>A0A074ZU20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169362.1">
        <property type="nucleotide sequence ID" value="XM_009171098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20320133"/>
    <dbReference type="KEGG" id="ovi:T265_05951"/>
    <dbReference type="CTD" id="20320133"/>
    <dbReference type="OrthoDB" id="6236189at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1425" mass="162158" checksum="B9430DCE20C2A609" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUB3</accession>
    <name>A0A074ZUB3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166817.1">
        <property type="nucleotide sequence ID" value="XM_009168553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUB3"/>
    <dbReference type="GeneID" id="20327528"/>
    <dbReference type="KEGG" id="ovi:T265_13361"/>
    <dbReference type="CTD" id="20327528"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="202" mass="21758" checksum="46760F4EEFA31144" modified="2014-10-01" version="1" fragment="single">GCGVGSCDLEAGADKLGCGVGSCDLEAGADKLVLFCGLKEEVRFIPNCSGLLHFLNFLFPPRPCPYIFYAENRRLFDYAQFCSGLINPDSQILFEYQLLKTYHPETRDQKNQTATKEAGFQQTCSQPQTGSPSGYTTGRDRDDFDELEGGPSVESSSGATDFGSGSSIETRRSVCSGTGAPNLSSAVTEELVDGEEWKVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV50</accession>
    <name>A0A074ZV50_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165262.1">
        <property type="nucleotide sequence ID" value="XM_009166998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV50"/>
    <dbReference type="GeneID" id="20316884"/>
    <dbReference type="KEGG" id="ovi:T265_02696"/>
    <dbReference type="CTD" id="20316884"/>
    <dbReference type="OrthoDB" id="9985779at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9783" checksum="9F4905D30BF39E78" modified="2014-10-01" version="1">MQKTIELCSQKSFSPVSFPAPYDLNSRSRGVVSLVPGHSQTGPSMQRSTCLVFSHPPTCTPYIFRHLPVLVQLNGAGPVRTVTYSPQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV56</accession>
    <name>A0A074ZV56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165265.1">
        <property type="nucleotide sequence ID" value="XM_009167001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV56"/>
    <dbReference type="GeneID" id="20316887"/>
    <dbReference type="KEGG" id="ovi:T265_02699"/>
    <dbReference type="CTD" id="20316887"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10207" checksum="7A260EAD71BC8536" modified="2014-10-01" version="1">MSSSKKDASSTYAEAGPWKFELPYSKVGSRLITGSSTIVKAQKLFGQLQPIRPSNKWKGGSNRGLIPHSPEADAPRCGTNVYTPTGRAEGRTPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVA3</accession>
    <name>A0A074ZVA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165191.1">
        <property type="nucleotide sequence ID" value="XM_009166927.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZVA3"/>
    <dbReference type="GeneID" id="20316817"/>
    <dbReference type="KEGG" id="ovi:T265_02629"/>
    <dbReference type="CTD" id="20316817"/>
    <dbReference type="OrthoDB" id="79771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1700"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1998"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1968"/>
            <end position="1978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2168" mass="240399" checksum="C43504C8EE3C1DBB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVT4</accession>
    <name>A0A074ZVT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597258">
        <property type="protein sequence ID" value="KER19284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176968.1">
        <property type="nucleotide sequence ID" value="XM_009178704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVT4"/>
    <dbReference type="STRING" id="6198.A0A074ZVT4"/>
    <dbReference type="GeneID" id="20329760"/>
    <dbReference type="KEGG" id="ovi:T265_15595"/>
    <dbReference type="CTD" id="20329760"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16917" checksum="F303EC012988ED56" modified="2014-10-01" version="1" fragment="single">ANVYHAYHILRASKIPAENITTIAYDDIANNLKNPFKGKVFHDYEHKDVYKGVVIDYRGKDVKPYIFTNVLKDDKKLEKRGESYGNANVYHAYHILRASKIPAENITTIAYDDIANNLKNPFKGKVFHDYEDKDVYKCVVIDYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXP0</accession>
    <name>A0A074ZXP0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597111">
        <property type="protein sequence ID" value="KER19974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176278.1">
        <property type="nucleotide sequence ID" value="XM_009178014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXP0"/>
    <dbReference type="STRING" id="6198.A0A074ZXP0"/>
    <dbReference type="GeneID" id="20325543"/>
    <dbReference type="KEGG" id="ovi:T265_11375"/>
    <dbReference type="CTD" id="20325543"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF362">
        <property type="entry name" value="INTESTINE-SPECIFIC HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="536" mass="60498" checksum="59B47903C29DFC67" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYC6</accession>
    <name>A0A074ZYC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4549 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165241.1">
        <property type="nucleotide sequence ID" value="XM_009166977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20316863"/>
    <dbReference type="KEGG" id="ovi:T265_02675"/>
    <dbReference type="CTD" id="20316863"/>
    <dbReference type="OrthoDB" id="76966at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040401">
        <property type="entry name" value="CCDC162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029376">
        <property type="entry name" value="DUF4549"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15082">
        <property type="entry name" value="DUF4549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4549" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1734"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2283"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1743"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1799"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2512" mass="286286" checksum="9529B450EB589B4D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYE5</accession>
    <name>A0A074ZYE5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163837.1">
        <property type="nucleotide sequence ID" value="XM_009165573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYE5"/>
    <dbReference type="STRING" id="6198.A0A074ZYE5"/>
    <dbReference type="GeneID" id="20315720"/>
    <dbReference type="KEGG" id="ovi:T265_01532"/>
    <dbReference type="CTD" id="20315720"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000006">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9860" checksum="A1CD3AF36B56CE7C" modified="2014-10-01" version="1">MSEVKMIQSELPEAMEGSAVSYAKDAMKLRTTESEMAKHVKTKMDAAFGKHWHCVVGKNFGSYVTHDPGNYVFFYVDKMAFQISRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYG2</accession>
    <name>A0A074ZYG2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597082">
        <property type="protein sequence ID" value="KER20184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176064.1">
        <property type="nucleotide sequence ID" value="XM_009177800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYG2"/>
    <dbReference type="GeneID" id="20325371"/>
    <dbReference type="KEGG" id="ovi:T265_11203"/>
    <dbReference type="CTD" id="20325371"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="336" mass="38641" checksum="3C552DD16CB0C87C" modified="2014-10-01" version="1">MLKQTKDRNWVSSNSSTHLSALYKVPHILLGRFINACRSQDRISQTPQAYSLYKFHEQCLWLCAVLSSLWIEGNCATWPKVHSKHFYKAVRLYMQPPAGSMKLNCGVIRTYGRCHVDRINFSDDFKKAREHERKFQYTSDLETSDVTSLVESKTTVCVVKTSFRNTRERSPSLPISPSPKKPRLMVPQSPPYPSFLQATPHALFPSTPERIPQHPAPVPSTSNQPVYMMPQTVHRLLHYTLNTAPEIPMFPVLSPLSAPFFQTPGTAALLQQNEQLHRKIDAMAEDHRYLKIRIDNSLLQVYSSSGTTGFTFPLRSKRSWDQLESKLQRYHARLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYJ1</accession>
    <name>A0A074ZYJ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167866.1">
        <property type="nucleotide sequence ID" value="XM_009169602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYJ1"/>
    <dbReference type="STRING" id="6198.A0A074ZYJ1"/>
    <dbReference type="GeneID" id="20318959"/>
    <dbReference type="KEGG" id="ovi:T265_04777"/>
    <dbReference type="CTD" id="20318959"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="22800" checksum="89C519E5AA0608E2" modified="2014-10-01" version="1">MDVEKARLEKLEKLRNMSDQVRIGGKGTARRKKKVIHKNAAVDDKKLQSTLKKLNLNTIPTIEEVNMYKADGTLIHFKNPKVQASPQANVFAVSGQAETKPLTDLFPNMLNQLESAKLRLSKMSVLANVKHSEVPTPSAAQPNNLEKTSPTPMTSVGRHFLQRLHQAQEGSREPHSGRRTTLTIPKHFVVSFTPFRKVTRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYU2</accession>
    <name>A0A074ZYU2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163989.1">
        <property type="nucleotide sequence ID" value="XM_009165725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYU2"/>
    <dbReference type="GeneID" id="20315847"/>
    <dbReference type="KEGG" id="ovi:T265_01659"/>
    <dbReference type="CTD" id="20315847"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="229" mass="25870" checksum="53DD0F6758E7F187" modified="2014-10-01" version="1">MNKLVKRGTLIIKLLEAPRQTSIKELLCGSGSEGIIITSYEKRRVFCGSEHPVKEVHRNVLNTAIPETWGDLVQRTLRLSNIINERFSQVPEVWFCGSLTWNPFGSLVCDVSWQLNVLYHATSCFGHCNIWNTATHSLTECAAQRQPRVSVGTIFDISQYICLKQSTPKFAEKCSTAHDRFRHSWASSPPSFRQTYVLIDLQMGVFFEIGPIWVQVEHKVDGNSGTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYY6</accession>
    <name>A0A074ZYY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZYY6"/>
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    <dbReference type="KEGG" id="ovi:T265_02503"/>
    <dbReference type="CTD" id="20316691"/>
    <dbReference type="OrthoDB" id="6766775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="179"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="468"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
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            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
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        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="750" mass="87417" checksum="C0A4E594F759FF32" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ43</accession>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
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            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20325160"/>
    <dbReference type="KEGG" id="ovi:T265_10992"/>
    <dbReference type="CTD" id="20325160"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="39" mass="4351" checksum="BD0A9A07394995AE" modified="2014-10-01" version="1">MPNFSSDQMVIHCGKARMDGILTSFTGHQRLNDSLNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ85</accession>
    <name>A0A074ZZ85_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009166608.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20316563"/>
    <dbReference type="KEGG" id="ovi:T265_02375"/>
    <dbReference type="CTD" id="20316563"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="9039" checksum="1AEC3740CAD0CB72" modified="2014-10-01" version="1">MSASSLVQFLIKTVHFLQFTGDEAARWLKWLEREFTDRKVRGSNPTSATRLPLSRLGRKTRKETANHLSYLTVDTMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZC6</accession>
    <name>A0A074ZZC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_01486"/>
    <dbReference type="CTD" id="20315674"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5001704397" description="Secreted protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17257" checksum="613035D9E66F31BE" modified="2014-10-01" version="1">MFLVPAAHVRWCRGRCSWLFAVLLKHGTSVCRTTQPTTSKHRISDRIVAWLGARRQIPPDRRVSSAERRWKRSSGHFKTPKNGCPVYYYSGMSLKLPDDIQNTKCVMRDMGIRRTRKTKGRGVSSIFLLIISEQQKRRRDNSLRHFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F5</accession>
    <name>A0A075A1F5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_00862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163021.1">
        <property type="nucleotide sequence ID" value="XM_009164757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F5"/>
    <dbReference type="STRING" id="6198.A0A075A1F5"/>
    <dbReference type="GeneID" id="20315050"/>
    <dbReference type="KEGG" id="ovi:T265_00862"/>
    <dbReference type="CTD" id="20315050"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="323" mass="35661" checksum="B2DF8D90F3AD4F47" modified="2014-10-01" version="1">MTHLTKLIDAIWSKKNVPAWGMSTVIPIFKKGTRTLCENYSGISVLAVASKVLSGIVVRGLTEHRERRTLKTKLGSVLQEDASIKSSPSDRFRNSDTASSNQQWLFFVIWKLPLALWTAKHYDSVCGAEALYANSRGRVKVYGKLSPEFTTSSGARQGCPLSLFLFNFIIDTIMEDSLPASNACGVEVLPGPPLTDIEYADDIALLGSDPMAVDLFAELGNWLANVSSPYEETSSVRSWCGPDKHPHFQISLIFTGDSSEYFVYDILQLNVLHTGRLMFQLIRYSRYHSLGDLAVSQPSCFFLAVRHRTVATAEGYCASVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U8</accession>
    <name>A0A075A2U8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174557.1">
        <property type="nucleotide sequence ID" value="XM_009176293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2U8"/>
    <dbReference type="STRING" id="6198.A0A075A2U8"/>
    <dbReference type="GeneID" id="20329198"/>
    <dbReference type="KEGG" id="ovi:T265_15032"/>
    <dbReference type="CTD" id="20329198"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16727">
        <property type="entry name" value="RING-HC_MIB1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="747"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="790" mass="86232" checksum="5032ED937A8AA98B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2X4</accession>
    <name>A0A075A2X4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596944">
        <property type="protein sequence ID" value="KER21729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174513.1">
        <property type="nucleotide sequence ID" value="XM_009176249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2X4"/>
    <dbReference type="GeneID" id="20324176"/>
    <dbReference type="KEGG" id="ovi:T265_10008"/>
    <dbReference type="CTD" id="20324176"/>
    <dbReference type="OrthoDB" id="6256563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704481" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="255" mass="29107" checksum="6B21F44421D0128B" modified="2014-10-01" version="1">MNNLVALLSSLPFITLHMCEPSCPPNIAELAPNVCLFRNGSVRSYCEAHKVCADYHELHGVHAFLIGKDTNYIEKFDRASIPDIETFTSINSLYRTRPHTGEAWRVGDPREANFTTSGMEFSWNKTGGSESRIVVYWHQKLVAVPQRDQMGVAMCQFSPSVHNFSAVEQFRKNWPPQGEIVTEGDSANGCWEVKTVHSKIQCAFSCKIHHYCRSFYYNEKTKECKQSIYVDSSLFVQDINSAGEWVRFGRPFWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3G5</accession>
    <name>A0A075A3G5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161982.1">
        <property type="nucleotide sequence ID" value="XM_009163718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3G5"/>
    <dbReference type="STRING" id="6198.A0A075A3G5"/>
    <dbReference type="GeneID" id="20314249"/>
    <dbReference type="KEGG" id="ovi:T265_00061"/>
    <dbReference type="CTD" id="20314249"/>
    <dbReference type="OrthoDB" id="6039349at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000054">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="458"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="61734" checksum="267D61AC1702A849" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5E0</accession>
    <name>A0A075A5E0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_02858"/>
    <dbReference type="CTD" id="20317046"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="46" mass="4992" checksum="4BE170CAB4711401" modified="2014-10-01" version="1" fragment="single">VESTSSNIQVQQTVQGGAVFFTCPRNSEDTSSIFGIQWTRAGRTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Q9</accession>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20328957"/>
    <dbReference type="KEGG" id="ovi:T265_14791"/>
    <dbReference type="CTD" id="20328957"/>
    <dbReference type="OrthoDB" id="10062329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18552" checksum="816CFB31B5D32EDC" modified="2014-10-01" version="1" fragment="single">KLLIRLLKTLRQPTTNSALLEAHQLGSVPEVSSTLFSTLTQIALFSRNTLICKSFWFSRETQVNLIYDILQLNELHTDCLMFQKLLTSLLKTLRQPPTGFALLGTHQKYTHLQINLVFTGDSTESLLHDILQLNVLQTGRLMSQLARFLRYRKHSNLGSNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Y5</accession>
    <name>A0A075A5Y5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5Y5"/>
    <dbReference type="GeneID" id="20323309"/>
    <dbReference type="KEGG" id="ovi:T265_09130"/>
    <dbReference type="CTD" id="20323309"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12332" checksum="EC0D58055ABAEBB1" modified="2014-10-01" version="1">MGMFCGMSDSCLKGRMFEFFLSRFDILLQKDQNQMPNDTELLPTLGPQLVAKFDKNFCSRDPTDLDPSDLGNDPEQSVGVCKSYLTQDSRDHGRIYSIDECIKNKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A600</accession>
    <name>A0A075A600_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rootletin-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165176.1">
        <property type="nucleotide sequence ID" value="XM_009166912.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A600"/>
    <dbReference type="GeneID" id="20316802"/>
    <dbReference type="KEGG" id="ovi:T265_02614"/>
    <dbReference type="CTD" id="20316802"/>
    <dbReference type="OrthoDB" id="3549872at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="217"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2100"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="411"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1590"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1660"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2130" mass="244537" checksum="5FE81115F1312B21" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6M3</accession>
    <name>A0A075A6M3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164990.1">
        <property type="nucleotide sequence ID" value="XM_009166726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6M3"/>
    <dbReference type="GeneID" id="20316665"/>
    <dbReference type="KEGG" id="ovi:T265_02477"/>
    <dbReference type="CTD" id="20316665"/>
    <dbReference type="OrthoDB" id="6249609at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="382" mass="42406" checksum="256701E6161A64C4" modified="2014-10-01" version="1">MLADEPIEVVDKFVYLGSCISPGGLTKDDVSIRIGKAKAAFVNLRHLRGLDTDPPVLVPSHVSVRLFRTLFLLLKGDQGLHSIRPHALPPLHLKACCAIEVSLNRLTFAKLRLDSTGPNRVLLEVWDSVPLKLPGGKEFRPQLCESVAANRELHPTHTTSLPVYTVDKRQRNKILSKWFTSGSESPSLDILLARLHGLAPHPSVLSHLSSLLKIPDVDRTTQGSLFYDHEKTSMRAALVHLDQNGVTPAYCETAGLLFRPVSFGQTPKARTTLADTIGYSQHALVLGFLCASLLPSSNPNSLAFPCIDEYSLSSWVGYRAEDWPRVVQEALQNYPDAYIRLTPPVRRSIPVRNHTEDILNMLISLVCLKIKLKIGFSLHTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6S5</accession>
    <name>A0A075A6S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162221.1">
        <property type="nucleotide sequence ID" value="XM_009163957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6S5"/>
    <dbReference type="GeneID" id="20314437"/>
    <dbReference type="KEGG" id="ovi:T265_00249"/>
    <dbReference type="CTD" id="20314437"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12085" checksum="31CB7215FE418B94" modified="2014-10-01" version="1">MCYTQAASCFIWHDIRDIAVYSHRNIRLTETRGLRLSDGPQEGRNRSWAVEEFSATLYRDELFRRNTLLTRLLNILRQHTAGFVLLGVHRVGEVFEFSSNLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A789</accession>
    <name>A0A075A789_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172957.1">
        <property type="nucleotide sequence ID" value="XM_009174693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A789"/>
    <dbReference type="GeneID" id="20322972"/>
    <dbReference type="KEGG" id="ovi:T265_08793"/>
    <dbReference type="CTD" id="20322972"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="18542" checksum="F6926A780A50821F" modified="2014-10-01" version="1">MYYIILNPKHLFKEPVAASDPFNEVDSLIVNVSSLASLSQCVHAFPEAFLPDQLDTTELLKFFKVDEQNCSPSVCDLEGRGTDDQDRIVRIGVNLRCKHMCRKNEAFAQASGAGFAPVVQRPPFTWKTQAKKGQRRSLNSQNEEENLTARGLKSAFNSGLNLIPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7G8</accession>
    <name>A0A075A7G8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172871.1">
        <property type="nucleotide sequence ID" value="XM_009174607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7G8"/>
    <dbReference type="GeneID" id="20322906"/>
    <dbReference type="KEGG" id="ovi:T265_08727"/>
    <dbReference type="CTD" id="20322906"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="368" mass="41321" checksum="5B56F3C432624392" modified="2014-10-01" version="1">MEISVGIKLESFGVLCDELLGEWLKLKFFREKWPRNSVANLETRDSSVVKAPAYGLRGPWLRHSGSIPVLVPPSVDTAARHRKVLRPINRRLSGVFGVVHKNITRKLSINAQPLVDTTQHIGSSCYTLNHRKPGDGWRYGQNLETIRQSLLVSVYVLRCQVINFPPLGRFYSAQGWTKRPLRGRRPPGMRKDRNIVCERPVSITTPEVSEAVGEISSSISITKLSKKGERTALSYTTGRGELRRELAVYPYAPTRVRTRCPHKAYKFGRGTFDCQTPPKFLTIDNIESGFQVKKNDQRGIMVVRMFARISPPSLKSAECRPTGPGFLSRFRIDISWWLGQPGSIPALVQPSGGMAARQRKDATAEQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A888</accession>
    <name>A0A075A888_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172608.1">
        <property type="nucleotide sequence ID" value="XM_009174344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A888"/>
    <dbReference type="STRING" id="6198.A0A075A888"/>
    <dbReference type="GeneID" id="20328759"/>
    <dbReference type="KEGG" id="ovi:T265_14593"/>
    <dbReference type="CTD" id="20328759"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15754" checksum="631D704E88908575" modified="2014-10-01" version="1" fragment="single">KWRDLLDRDNTGVVTLNEFCQTLGLRPASIHPQRQMLVRQVPLNRSQIRVVMATMSRAMQEQIGEDVCWMTRDCKTSNEQLADRIKKHLDKRFGRTWQVVICQGSSWASFTHLPETAFFFQLDKNVYLIWKTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9X9</accession>
    <name>A0A075A9X9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596813">
        <property type="protein sequence ID" value="KER24354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171892.1">
        <property type="nucleotide sequence ID" value="XM_009173628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9X9"/>
    <dbReference type="GeneID" id="20322136"/>
    <dbReference type="KEGG" id="ovi:T265_07957"/>
    <dbReference type="CTD" id="20322136"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10232" checksum="47E2882A7C91A91B" modified="2014-10-01" version="1">MCTTSGDGGRGRQPGNIPTLVPPSCGMEAEHQNGVTAGRVWKEIITAISCPHFSQNETGCCSATTGKWLKPTQQCESQNFERHQSVQTIQTGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAR3</accession>
    <name>A0A075AAR3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_07741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171604.1">
        <property type="nucleotide sequence ID" value="XM_009173340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAR3"/>
    <dbReference type="STRING" id="6198.A0A075AAR3"/>
    <dbReference type="GeneID" id="20321920"/>
    <dbReference type="KEGG" id="ovi:T265_07741"/>
    <dbReference type="CTD" id="20321920"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11563" checksum="F1E90557FC790C79" modified="2014-10-01" version="1">MKGKVGDNLMYLAHRHNVEIEGACEASLACSTCHVYVSSPYYDMLPEPVEEEEDMLDLAVFLRDNSRLSCQIYLTKELDGMTITLPKATRNFYVDGHVPKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABJ6</accession>
    <name>A0A075ABJ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163031.1">
        <property type="nucleotide sequence ID" value="XM_009164767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABJ6"/>
    <dbReference type="GeneID" id="20315060"/>
    <dbReference type="KEGG" id="ovi:T265_00872"/>
    <dbReference type="CTD" id="20315060"/>
    <dbReference type="OrthoDB" id="6297697at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="17803" checksum="EEDB21CC8F8C902D" modified="2014-10-01" version="1">MCTSRGNERTVQLYSEMKKGRDKNSYMTRKRRLDLLRNLIEAYDARSFNGLSLALTYDERDYIYGEYGPQWRETAEHCISNYMMRILTEQQTSRFEDHKPTNSHNRDCQHPKDTRDGEHRLDLLFYVNKINKQDFLCNLARIMNKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABQ3</accession>
    <name>A0A075ABQ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171144.1">
        <property type="nucleotide sequence ID" value="XM_009172880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABQ3"/>
    <dbReference type="GeneID" id="20321555"/>
    <dbReference type="KEGG" id="ovi:T265_07376"/>
    <dbReference type="CTD" id="20321555"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="327" mass="36962" checksum="98FA1948B867BC14" modified="2014-10-01" version="1">MKGYKQNSHKKKPERFSSPFLNRFYLRRRVKALCTEEADRTVAQSDAKDKLRGSGYPASMIKPQLRMVLAQVAKLSREWFGTAVVPYKPGTSELTMVRKSRIISQLLEISEYIFTMEHTTQKAVETLPLPTPEKDKILLVSSGRRSAQVSVNLELLKTSRKRDLAGSRMIVDTSSAATGEARQKLHRPKVFEVVRYVGVIFWVPDYRNSGTVADCTPMKVQKNQATEHNFAPFSGFRSLSHEAPDTGDVKDPPCGLPRNQKLYPLTQTQLLFANGNGFSTLLNTSMLSQHRHDAYSQSNEKHRWAATYGCIGEYVWTSLSHTFNCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE74</accession>
    <name>A0A075AE74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169731.1">
        <property type="nucleotide sequence ID" value="XM_009171467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE74"/>
    <dbReference type="STRING" id="6198.A0A075AE74"/>
    <dbReference type="GeneID" id="20320439"/>
    <dbReference type="KEGG" id="ovi:T265_06257"/>
    <dbReference type="CTD" id="20320439"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="19406" checksum="7E7F9AE8BF4956AE" modified="2014-10-01" version="1">MRCAPRGLRDSEGGTENNTRLGRRMNDSESPVATMCNTTVNAPVQTLKSKRPEERVTWSTLRGDFAITQLEPVPQEASTSKNSGILPDRESDKSVHHAFLISPHIKQTILGEDFLMGTDSVVDLKQGKLVTGYCAIELEGYPSTVLSELHVRKLPSFNVPSVQSVVKEYSELFTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEK9</accession>
    <name>A0A075AEK9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169452.1">
        <property type="nucleotide sequence ID" value="XM_009171188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEK9"/>
    <dbReference type="GeneID" id="20320211"/>
    <dbReference type="KEGG" id="ovi:T265_06029"/>
    <dbReference type="CTD" id="20320211"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15529" checksum="76B6F8557851134F" modified="2014-10-01" version="1">MAIDPTNSAAKLIGQNVDYFERWTSLDNDDVKEDRIRQQRREDPVGSNSIRSTECLGISQRTEIRQDVDNFGVTLLSRQMKSIRAHTGLCVHIDSFAEEETDHIRLCKKEARMWVIMGKRQDKADESTAYRSPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEY5</accession>
    <name>A0A075AEY5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169064.1">
        <property type="nucleotide sequence ID" value="XM_009170800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEY5"/>
    <dbReference type="STRING" id="6198.A0A075AEY5"/>
    <dbReference type="GeneID" id="20319909"/>
    <dbReference type="KEGG" id="ovi:T265_05727"/>
    <dbReference type="CTD" id="20319909"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35296" checksum="95B40687492D6CF1" modified="2014-10-01" version="1">MGNVVRAASPQGDAPKQLPVSEGPEKTALPNEGPGTIETIHNKAHEVFPVPFDGAKLVINKGLSQNFQVNHSLSLCNDEQGGYRFGVTYVGHQKVSETESYPILMGELQPNGNLQAHIIHRLTPLVYIRYAAQAQRNKMVGQQLVTELKAKKWQTAFTIVNPDINRGQAMAAVDVMKQVSNRVALGSMFFYQRSPQLPSKQNGVWSIGGKYTSDNWQACATLRPWQLGIHTSLHLQVNESLQLAAELESSHQQQTNTTTLGYKYDIPKANVTFKAQLDSNWNIASSLEKKLTPFPFTFTLCALGNQTKAKYAFGIGLMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGA7</accession>
    <name>A0A075AGA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167657.1">
        <property type="nucleotide sequence ID" value="XM_009169393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGA7"/>
    <dbReference type="GeneID" id="20318793"/>
    <dbReference type="KEGG" id="ovi:T265_04611"/>
    <dbReference type="CTD" id="20318793"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12352" checksum="8C06D2D36C08C15F" modified="2014-10-01" version="1">MWNSASEKVGCLVRKIWPGLQALSIKQTTHKVAENSSTAYGRFHPSWDSSSRCSSRVSVNPMFYSNPNWTVFQKYTHLQITFYVFTKETTHKVAENILRFLEYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGP5</accession>
    <name>A0A075AGP5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_04316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167289.1">
        <property type="nucleotide sequence ID" value="XM_009169025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGP5"/>
    <dbReference type="GeneID" id="20318498"/>
    <dbReference type="KEGG" id="ovi:T265_04316"/>
    <dbReference type="CTD" id="20318498"/>
    <dbReference type="OrthoDB" id="6259358at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052160">
        <property type="entry name" value="Gypsy_RT_Integrase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47266">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="803" mass="90856" checksum="32864B991E0E2C09" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIC0</accession>
    <name>A0A075AIC0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164916.1">
        <property type="nucleotide sequence ID" value="XM_009166652.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AIC0"/>
    <dbReference type="GeneID" id="20316607"/>
    <dbReference type="KEGG" id="ovi:T265_02419"/>
    <dbReference type="CTD" id="20316607"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="135"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="923"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1562"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="861"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1562"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1576"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1595"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1624"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2272" mass="251290" checksum="F7A2F07D903FB19B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJE6</accession>
    <name>A0A075AJE6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163116.1">
        <property type="nucleotide sequence ID" value="XM_009164852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJE6"/>
    <dbReference type="GeneID" id="20326838"/>
    <dbReference type="KEGG" id="ovi:T265_12670"/>
    <dbReference type="CTD" id="20326838"/>
    <dbReference type="OrthoDB" id="6272054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11410" checksum="54232057D837C892" modified="2014-10-01" version="1">MVGCRRIFSNLMSSTLHIYMCRDILNIRLRHEAAWCGTFSCLRTSQTRDSAGFQLAKYPTREPAQFLPPAYHCVPHNRSESVNLVGASLLVLTKPMTAAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AK05</accession>
    <name>A0A075AK05_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162061.1">
        <property type="nucleotide sequence ID" value="XM_009163797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AK05"/>
    <dbReference type="STRING" id="6198.A0A075AK05"/>
    <dbReference type="GeneID" id="20314328"/>
    <dbReference type="KEGG" id="ovi:T265_00140"/>
    <dbReference type="CTD" id="20314328"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="4">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22677" checksum="5F46C5FA314BB77B" modified="2014-10-01" version="1">MDQSNQTIQFRVPVQTFELHSGISDPQECWETIQPDISAGGMIAPPDKSIWFQGCAILRSLIPARLLVMSAFIGSWKLSESQNFDEFLRELGVNFFIRKAASTSKPTITFDKFGDNGLKMKTETILKTTEQSFTFGEEFDETTIDGRQVKSTVTKDSDTQLTQVQKHCDGDTVIVRKIEGDTMVTTATFKNVTSVRKYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YT61</accession>
    <name>A0A074YT61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL624488">
        <property type="protein sequence ID" value="KER17986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178267.1">
        <property type="nucleotide sequence ID" value="XM_009180003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YT61"/>
    <dbReference type="GeneID" id="20330539"/>
    <dbReference type="KEGG" id="ovi:T265_16374"/>
    <dbReference type="CTD" id="20330539"/>
    <dbReference type="OrthoDB" id="10036174at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8943" checksum="4992321B28ADD104" modified="2014-10-01" version="1" fragment="single">SRQTNSRPSLSREASFEEQQLQRELDASRERETDLSEQLRFAEEEVRKMKRRVKESQVENELLSKKLERLYTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUN1</accession>
    <name>A0A074YUN1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="5">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_16074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:41733"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KL601656">
        <property type="protein sequence ID" value="KER18413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177840.1">
        <property type="nucleotide sequence ID" value="XM_009179576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUN1"/>
    <dbReference type="STRING" id="6198.A0A074YUN1"/>
    <dbReference type="GeneID" id="20330239"/>
    <dbReference type="KEGG" id="ovi:T265_16074"/>
    <dbReference type="CTD" id="20330239"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER18413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11934" checksum="21D38FD24464D7B7" modified="2014-10-01" version="1" fragment="single">DIIRRYRGGGVPHTTFDEFPKKVAIQLNDTHPSLAIPELMRILVDLEGLSWKKAWEISYNTFAYTNHTILPEALERWPVSLLEHILPRHLQIIFQINAEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVC4</accession>
    <name>A0A074YVC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598657">
        <property type="protein sequence ID" value="KER18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177563.1">
        <property type="nucleotide sequence ID" value="XM_009179299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVC4"/>
    <dbReference type="GeneID" id="20330053"/>
    <dbReference type="KEGG" id="ovi:T265_15888"/>
    <dbReference type="CTD" id="20330053"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="8078" checksum="6B4EC7A9F94771F3" modified="2014-10-01" version="1" fragment="single">MWHSIRGNATYEDSTRIFSMAECSRFTCDNCMNIKMEIELLQYYVHIEFVVRLRADGEVKQKEPDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVY3</accession>
    <name>A0A074YVY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597463">
        <property type="protein sequence ID" value="KER18931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177322.1">
        <property type="nucleotide sequence ID" value="XM_009179058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVY3"/>
    <dbReference type="GeneID" id="20326262"/>
    <dbReference type="KEGG" id="ovi:T265_12094"/>
    <dbReference type="CTD" id="20326262"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703709" description="Peptidase C13 family protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15492" checksum="C37E45272A246F0A" modified="2014-10-01" version="1">MRHFSLILALLFCIDNVGWLEAAGVHSWSSIFNNKPSKNWVVLAAGSNTWQNYRHQADVYHAYQVVRKHKVPAKNIITFAFDDITNNPKNPFKGKVFHDYEHEDVYKGVVIDYRGKVSPCSGAQKSSEFLHHFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWY2</accession>
    <name>A0A074YWY2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597246">
        <property type="protein sequence ID" value="KER19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176936.1">
        <property type="nucleotide sequence ID" value="XM_009178672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWY2"/>
    <dbReference type="GeneID" id="20329745"/>
    <dbReference type="KEGG" id="ovi:T265_15580"/>
    <dbReference type="CTD" id="20329745"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703782" description="Peptidase C13 family protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26537" checksum="349FE8881F40A366" modified="2014-10-01" version="1" fragment="single">MKLQVNLNMMRRCSLLFEFLFCINHLARLNAVSVHNWSSKFNNNPSKNWVVLVAGTNTWRNYRHQADVFHAYQIVRKNNVPAENIITFAYDDIANKPRNPFKGKVFHDYLYEDIYQGVEIDYRGKDVTRDNFVKVLKGDEKLAANKKKVLKRISLPIICFTILRIFDGDLYDPLSAVYVTTSAKETEQSWSIFCDDTDIDVCLASEYAYAWIGDSEYVSISKKPLQISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX60</accession>
    <name>A0A074YX60_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597225">
        <property type="protein sequence ID" value="KER19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176863.1">
        <property type="nucleotide sequence ID" value="XM_009178599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX60"/>
    <dbReference type="GeneID" id="20325990"/>
    <dbReference type="KEGG" id="ovi:T265_11822"/>
    <dbReference type="CTD" id="20325990"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45505" checksum="7FB65445517558A6" modified="2014-10-01" version="1">MKLQVNLNMMPRASLLFEFLYCINHLAWLGAVDVHNWSSIFNNNPSKNWVVLVAGTNTWRNYRHQADVYHAYQVVRKNNVPAENIITFAYDDIANNPKNPFKGKVFHDYMHEDIYQGVEIDYRGKLHAVELNEILAHMHSKKKYNKLVLYVEACYSGSLFRNMLPPNVGIYVTTASKEDEKSWSIFCDDKDFDMCLAGEYAYAWIKDSEYHDLKTRTLQQQYEEVRKRTANSHVMQYGEMGIGSLPVGKFQGHYDLPIHRYDGTIPLSAADRQSSLQAHLFSKSRRLMEATTEQEHEAAWRKLHRASQLGRIVKETFRDIVGEVMTHHKPTLKGLSKRDKLMCFQAVFDQLRTHCFTIQQVPEVAQHTTHLIALCKAGYMAETLIDSVYNICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY18</accession>
    <name>A0A074YY18_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597177">
        <property type="protein sequence ID" value="KER19568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176688.1">
        <property type="nucleotide sequence ID" value="XM_009178424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY18"/>
    <dbReference type="STRING" id="6198.A0A074YY18"/>
    <dbReference type="GeneID" id="20325871"/>
    <dbReference type="KEGG" id="ovi:T265_11703"/>
    <dbReference type="CTD" id="20325871"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF52">
        <property type="entry name" value="IP16409P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="24945" checksum="4871B212C44C0B67" modified="2014-10-01" version="1">MRGANLQVELSDSDQLQTQIRHDERRWSAADLDEDGKLSFPEFAMFLHPHLYPVMRAVLSAEVLETMDQDKDAQVSEEEYISEIARAHRRVFYRGLPQPPWVDREKVQFRMYLDLDKNGSLDQQEIGEWLFPKDYDEVDSEVLHLLLYLDSNQDGALTRSEVLQDLHLFLRSQRTPTKQLEIIQQENAYLICTLILKTERPHVSSRTFVNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYK7</accession>
    <name>A0A074YYK7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597147">
        <property type="protein sequence ID" value="KER19733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176518.1">
        <property type="nucleotide sequence ID" value="XM_009178254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYK7"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325738"/>
    <dbReference type="KEGG" id="ovi:T265_11570"/>
    <dbReference type="CTD" id="20325738"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39453" checksum="DB10E4BC613F3F45" modified="2014-10-01" version="1">MYSSSNPFKGKVFHDYEHEDVYMGVVIDYRGKVSPCSGNKELEANKKKVLKSGPDDNVFLFFSGHGGVSFLRLIAEDLHAVELNDILAHMHSKKKYNKMVLYVEACYSGSLFRNILPPNMGIYVITSAKEDEQSWSIFCTDKDIDTCLASEFAYAWTKDSEYHDMKRHTLDQQYEEAKKVTADSHVMKYGEMAMGSLLVGKFQGHYVLPMHRSDGTIPRNAVDRKPSCQAHLFPKSRRLMETATEGEHENAWRKLHRATQLSHIFKETLRDIVVDVTTHHKPTLKGLSKSDELMCFQAVFDQFRTHCFTIQKVPEVAQHTTRLMELCKAGYEAEILIDSVHNVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZX1</accession>
    <name>A0A074YZX1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597079">
        <property type="protein sequence ID" value="KER20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176048.1">
        <property type="nucleotide sequence ID" value="XM_009177784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZX1"/>
    <dbReference type="GeneID" id="20325357"/>
    <dbReference type="KEGG" id="ovi:T265_11189"/>
    <dbReference type="CTD" id="20325357"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704852" description="Peptidase C13 family protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="110006" checksum="24F0C14CF3C722F2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0N3</accession>
    <name>A0A074Z0N3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597370">
        <property type="protein sequence ID" value="KER19032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177217.1">
        <property type="nucleotide sequence ID" value="XM_009178953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0N3"/>
    <dbReference type="GeneID" id="20326207"/>
    <dbReference type="KEGG" id="ovi:T265_12039"/>
    <dbReference type="CTD" id="20326207"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="24852" checksum="1C8B0A09BDCABC6D" modified="2014-10-01" version="1">MSNGAHFKVTGKVQLNVKNLRMGNDIPQKPATSDDDSKPSAFVIETDSLPFTHAASVVHNMHKDMHKNYRSKIIMRPIATRSPPSCSSVKCPSNLVYDRDSVLKAAKPYRDGSYSKSTVTRQRTNGDDCGLQGKGTVCNHRQQLLKLLDEVTHVPLKPHQRMEITRNYLIPKRSCSVKFTKTRSKDWTITSDNLFVGGYVYRGTPQSATSTPVNSMEGLVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0S6</accession>
    <name>A0A074Z0S6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597042">
        <property type="protein sequence ID" value="KER20563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175689.1">
        <property type="nucleotide sequence ID" value="XM_009177425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0S6"/>
    <dbReference type="STRING" id="6198.A0A074Z0S6"/>
    <dbReference type="GeneID" id="20325079"/>
    <dbReference type="KEGG" id="ovi:T265_10911"/>
    <dbReference type="CTD" id="20325079"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09343">
        <property type="entry name" value="LIM1_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09341">
        <property type="entry name" value="LIM2_Testin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09347">
        <property type="entry name" value="LIM4_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09425">
        <property type="entry name" value="LIM4_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09430">
        <property type="entry name" value="LIM5_LIMPETin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000070">
        <property type="entry name" value="Four and a half LIM domains 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000066">
        <property type="entry name" value="Four and a half LIM domains protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000081">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF4">
        <property type="entry name" value="PROTEIN ESPINAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
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    </dbReference>
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        <property type="entry name" value="LIM_FHL2-3_N"/>
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    </dbReference>
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        <property type="entry name" value="LIM"/>
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    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="446"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="506"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="563" mass="64354" checksum="7D8542B5719E2DD6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2K2</accession>
    <name>A0A074Z2K2_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KER19732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178265.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074Z2K2"/>
    <dbReference type="GeneID" id="20325746"/>
    <dbReference type="KEGG" id="ovi:T265_11578"/>
    <dbReference type="CTD" id="20325746"/>
    <dbReference type="OrthoDB" id="6417226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="411"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="757"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="759"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="923" mass="103190" checksum="48677B0BAF1082BA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2W3</accession>
    <name>A0A074Z2W3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174933.1">
        <property type="nucleotide sequence ID" value="XM_009176669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2W3"/>
    <dbReference type="GeneID" id="20324501"/>
    <dbReference type="KEGG" id="ovi:T265_10333"/>
    <dbReference type="CTD" id="20324501"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10799" checksum="2E43BCFA268B59AA" modified="2014-10-01" version="1">MACLGAIRKAHSWDKKKAMPSFKDDSVDKVRHALNAGHLELTFASRATLTAGNLTTLSHHQYVSISEGPDNQSGHMPTQLTKQVPVNSVKQIIKLIHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Z0</accession>
    <name>A0A074Z2Z0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596972">
        <property type="protein sequence ID" value="KER21363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174884.1">
        <property type="nucleotide sequence ID" value="XM_009176620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Z0"/>
    <dbReference type="STRING" id="6198.A0A074Z2Z0"/>
    <dbReference type="GeneID" id="20324462"/>
    <dbReference type="KEGG" id="ovi:T265_10294"/>
    <dbReference type="CTD" id="20324462"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="376"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="450" mass="49619" checksum="CD9D48CAF05E88FE" modified="2014-10-01" version="1">MKLRRFLLRYYPPEYEQGGTTKTKSLDLLDLTFKCVVKFITGYRTRSNTDEILNEICEKEALVTEKRKPQVYELIERLKAKLVKVDKTKFGAYQVLRAHILPLTNVAFNKSGSHFITGSYDRTCKIWQTESGEEVHTLEGHRNVVYAIAFNLPFSDKIATGSFDKTARLWSAETGECHHVFQSHSAEVVCLQFNPVSTILATGGMDTLAKLWDIETGTELASLSGHTAEVIALQFSQGSSVSSEGDSGGYSDTVCGAGAGRLMLTGSFDHTVSLWDVRSGERTHHLIGHAAEVAAAAFSFDASLVTTASMDKTVRVWDTRTGRQLHVLTGHLDEVLDVTFDASGRRLVSASADSTSRVWDLRGSGPNRGYREIAHLTGHDGEVSKVCFNSRGTLVLTASADKTARLWDAETGQLKDILVGHTDEVFSCAFNYEGDTIITGSKDNTCRIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z412</accession>
    <name>A0A074Z412_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174474.1">
        <property type="nucleotide sequence ID" value="XM_009176210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z412"/>
    <dbReference type="STRING" id="6198.A0A074Z412"/>
    <dbReference type="GeneID" id="20324141"/>
    <dbReference type="KEGG" id="ovi:T265_09973"/>
    <dbReference type="CTD" id="20324141"/>
    <dbReference type="OrthoDB" id="10059177at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="302" mass="32556" checksum="52BAF7F1BF72B99E" modified="2014-10-01" version="1">MSLYPTFEELKVDQLLNEQNAAVRDAYASMASYMGLDLNNFHYDAHGELVPGPPPNSTHPEAPSPYPAIQTPSIMPQPATGPQTVAGAQPVAVPFGSGSRALVTPTGPTSEIKQGLRRVVLCKNSEGKVGVQLVSVDNGVFVSMVRKDSPAALGGLRFGDQIISVCGKLMAGKSGESAMKTLRKAPVNNIELIVRDRPFERTIMVNKSSSGNIGITLNDGEIIAVVADSSAARNGVLTKHQVVEVNGRNVMGMKDKELKELLHCNRDPVQLTVLPTVIYKHLVKRLLNNQIRREMDRSDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4X0</accession>
    <name>A0A074Z4X0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596919">
        <property type="protein sequence ID" value="KER22108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174153.1">
        <property type="nucleotide sequence ID" value="XM_009175889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4X0"/>
    <dbReference type="STRING" id="6198.A0A074Z4X0"/>
    <dbReference type="GeneID" id="20323894"/>
    <dbReference type="KEGG" id="ovi:T265_09726"/>
    <dbReference type="CTD" id="20323894"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705">
        <property type="entry name" value="AGAP000321-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47705:SF1">
        <property type="entry name" value="PNP_UDP_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130764" checksum="C9F68A31E97FE7BB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z574</accession>
    <name>A0A074Z574_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597034">
        <property type="protein sequence ID" value="KER20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175597.1">
        <property type="nucleotide sequence ID" value="XM_009177333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z574"/>
    <dbReference type="GeneID" id="20325016"/>
    <dbReference type="KEGG" id="ovi:T265_10848"/>
    <dbReference type="CTD" id="20325016"/>
    <dbReference type="OrthoDB" id="6246791at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042621">
        <property type="entry name" value="TTC23/TTC23L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485:SF2">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14485">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="89997" checksum="5BD91F9C09CF4632" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z593</accession>
    <name>A0A074Z593_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="589" mass="64847" checksum="66136D2E7908C1DB" modified="2014-10-01" version="1"> </sequence>
</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7134" checksum="CED4891CC2E324E6" modified="2014-10-01" version="1">MSSSSLEPSRRRWTGRRRRQPERIQVDPRRWASDAALSRAFHGLATTIDSSVTPNNRSARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z642</accession>
    <name>A0A074Z642_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_15885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER18695.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20330050"/>
    <dbReference type="KEGG" id="ovi:T265_15885"/>
    <dbReference type="CTD" id="20330050"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8501" checksum="72CB1CC917EF3AC1" modified="2014-10-01" version="1" fragment="single">MMGGNLLSVGWHGSLVSFLAENSSQSVISSTPNEASPVHTDLCVIRTPTSPKVLFYDQTGFTSFSDTHEKLFCTPQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6R1</accession>
    <name>A0A074Z6R1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596881">
        <property type="protein sequence ID" value="KER22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173482.1">
        <property type="nucleotide sequence ID" value="XM_009175218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6R1"/>
    <dbReference type="STRING" id="6198.A0A074Z6R1"/>
    <dbReference type="GeneID" id="20323384"/>
    <dbReference type="KEGG" id="ovi:T265_09205"/>
    <dbReference type="CTD" id="20323384"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16311" checksum="A345A994DA72E08A" modified="2014-10-01" version="1">MKEITKRLGAVGATRLPGLGRRDPHCAWLGTLQDMAANRCQWRYCCQFLSRLPDEALLIIIIIVIIIIIIIIIIIIIIIIIIDSTTSLFNTDASLPYNHDSLGSIINTLLIRLLKNLQQYTTCFAHPEAQQLDTVWKLLSISCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6X1</accession>
    <name>A0A074Z6X1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_14772</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KL596877">
        <property type="protein sequence ID" value="KER22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173420.1">
        <property type="nucleotide sequence ID" value="XM_009175156.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z6X1"/>
    <dbReference type="GeneID" id="20328938"/>
    <dbReference type="KEGG" id="ovi:T265_14772"/>
    <dbReference type="CTD" id="20328938"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="2191"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1606"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2249" mass="250175" checksum="E0274E05AF6D2BB3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z734</accession>
    <name>A0A074Z734_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596971">
        <property type="protein sequence ID" value="KER21387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174880.1">
        <property type="nucleotide sequence ID" value="XM_009176616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z734"/>
    <dbReference type="GeneID" id="20324458"/>
    <dbReference type="KEGG" id="ovi:T265_10290"/>
    <dbReference type="CTD" id="20324458"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9751" checksum="18EA8215D8D62471" modified="2014-10-01" version="1">MEKKHVDNPRDDNFLPVGRNSSAYIKRCGQIKRRTYDQVDEPSNLETAGSTTKTMEPAQSPDVIGTSAGDLSKSVIDSNAVQALRQANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7D2</accession>
    <name>A0A074Z7D2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173169.1">
        <property type="nucleotide sequence ID" value="XM_009174905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7D2"/>
    <dbReference type="GeneID" id="20328879"/>
    <dbReference type="KEGG" id="ovi:T265_14713"/>
    <dbReference type="CTD" id="20328879"/>
    <dbReference type="OrthoDB" id="6248109at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="916" mass="98294" checksum="A1EEA0A9D1593E41" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z832</accession>
    <name>A0A074Z832_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA processing factor 3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">T265_08740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074Z832"/>
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    <dbReference type="KEGG" id="ovi:T265_08740"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8C9</accession>
    <name>A0A074Z8C9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20322924"/>
    <dbReference type="KEGG" id="ovi:T265_08745"/>
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    <dbReference type="OrthoDB" id="6255024at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16233" checksum="C0F893C52148BC6B" modified="2014-10-01" version="1">MVPKLLCLPMQAYLWMLFNYLLPAVIMISSHAYVIHVLRHPTPGQQRDRQVQNNVRRLILTTSLMAGLLTVLHFYEAIRYILANSNVIRYAAGAAIQQVGALLITLSALLNPCVLLATCETARMQDSPRIPRSSHQSPGQERVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA67</accession>
    <name>A0A074ZA67_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA67"/>
    <dbReference type="GeneID" id="20323623"/>
    <dbReference type="KEGG" id="ovi:T265_09454"/>
    <dbReference type="CTD" id="20323623"/>
    <dbReference type="OrthoDB" id="5839471at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="419" mass="47331" checksum="DCC005D120745FAB" modified="2014-10-01" version="1">MLIENVPFGMVVGGAKDVYDGSFDGIIGLGRRAMCPEHTEPVFHFFSQKGIMSRQFGVECQDGSASFMMGDDLQQLLSTDMTFVNVVKGPYWETSFDWIFVFNTGFSTGDHRMMFDTGAGGISLPGDIHMAMNEILGIKKQLNRAYVFDCEKLPSLPPVEFRIQGKSFKIMPKQYTKQPCGYCAGNVISTFIPTNIRRPNDTLNLFRRISEGLDKLERDKRTMFQIPLYPWGDSQYICKISIEQTEFRMLLDTGSPSIWVPSDRFGDTLIKNTPFGLVMDATEKVSVSPFDGIIGLGRRSMSPEQTQPLLYAVHQQMQMRRKFGFQFQDRGGSFWMGENAKQIFSNDVTYVNVIDGPYWETRTTTNGETTCRTLFYNTSSDCPVGLIMGMSFLHSFQLIFDDNAGKVGFAARSDKSIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAC7</accession>
    <name>A0A074ZAC7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173724.1">
        <property type="nucleotide sequence ID" value="XM_009175460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAC7"/>
    <dbReference type="STRING" id="6198.A0A074ZAC7"/>
    <dbReference type="GeneID" id="20328994"/>
    <dbReference type="KEGG" id="ovi:T265_14828"/>
    <dbReference type="CTD" id="20328994"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="431" mass="48077" checksum="B76C9CBCC34778EE" modified="2014-10-01" version="1" fragment="single">SSPQRPLTEGSQWSQPNVHKHPAPSIVNHIPAKRPLSAVPRPLPDNNNIQKPSSKLPACLKKLVRSIVRTFYSREHSLIVDMLVRNTIMKEDDLCERLRFEKKQLRQYLHTLKTDQFIKSKLQLETDAEGKTTKITHYFIDYKLFVNVVKYRLDQMRRRLEAEQRQTTSRASFRCVSCATTYTDLEVDRLISLDNPGKLECVYCRAEVAEEEDNVSRTDARALIASFHHQVRDPIDAMLRECDEIHLSSSILEPEIRPLEPLKDESERSLDAVTTTKPPWETRPFAETDNKQNSTPTVAAENKVRIVLSGQSSVSSPVVKQRPIWMCDSTINSGQSADNAFTPAMGAGVTLSDSLTQTLTPGRVPTGFSTLGATSLKETSSDASGSANPTSSATSGDIMQLLLIHERRGISSHTASKSMQPSGTSFPIGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAG7</accession>
    <name>A0A074ZAG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597079">
        <property type="protein sequence ID" value="KER20205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176050.1">
        <property type="nucleotide sequence ID" value="XM_009177786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAG7"/>
    <dbReference type="GeneID" id="20325359"/>
    <dbReference type="KEGG" id="ovi:T265_11191"/>
    <dbReference type="CTD" id="20325359"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36775" checksum="90AEA431F71E8D6D" modified="2014-10-01" version="1">MKLPENPERHMELEVNLDMMRPCSVLIAFLFCINHVAVLEGVGFQNCSSIFYNQPSKNWVVLVAGSKTWRNYRHQADVFHAYQLVRKNNVPPENIITFAYDDIANNPNDDDVDDDDDDDSDDDDSDDDYDSEDNHDSGGNDDDDGNDEDDGDVDDDDVNDQDDNDGDNADVDDGDEGDNVAVDGGDDAVYGDDDNEQDDDDDQDEDVDDFDHDDTDDDQDDDDDKDDEDDINPFKGQVFNHYDHLDVYNGVVIDYRGKVSLCSDARQSDEFLHRFTDVTRDNFVKVLKGDEKLEADKKKVLKRSSPYHLLQFGKQLMYGKSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAI9</accession>
    <name>A0A074ZAI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172146.1">
        <property type="nucleotide sequence ID" value="XM_009173882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAI9"/>
    <dbReference type="GeneID" id="20322341"/>
    <dbReference type="KEGG" id="ovi:T265_08162"/>
    <dbReference type="CTD" id="20322341"/>
    <dbReference type="OrthoDB" id="10456317at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9153" checksum="EEC3FA410608F085" modified="2014-10-01" version="1">MIGHLIVFFNRPASPGQPITDFWKVVKLGSPSKNHSAVTSFRCLGRKHEGWGTARLPKPRQGKSRGRGRVRTTDLPVSKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAQ4</accession>
    <name>A0A074ZAQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171871.1">
        <property type="nucleotide sequence ID" value="XM_009173607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAQ4"/>
    <dbReference type="GeneID" id="20322121"/>
    <dbReference type="KEGG" id="ovi:T265_07942"/>
    <dbReference type="CTD" id="20322121"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="7931" checksum="F421E2266AC866B8" modified="2014-10-01" version="1">MSGSILAVVLREVEKIHNDISRWADAIESNNPSSANNIVSVLEAYNEIGSKLDPKLLCQDASMIYPLNRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCB4</accession>
    <name>A0A074ZCB4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173011.1">
        <property type="nucleotide sequence ID" value="XM_009174747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCB4"/>
    <dbReference type="GeneID" id="20323014"/>
    <dbReference type="KEGG" id="ovi:T265_08835"/>
    <dbReference type="CTD" id="20323014"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10090" checksum="2970FFFF2E706C50" modified="2014-10-01" version="1">MDENAEIYAQINPYTTFRSAVKAEKYDVKNLELVKVFKHMQCCDYSGIAQVDVILCNMMMLFSSTQPSPDAAVKRNYSEILGRLVACQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCI3</accession>
    <name>A0A074ZCI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171246.1">
        <property type="nucleotide sequence ID" value="XM_009172982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCI3"/>
    <dbReference type="STRING" id="6198.A0A074ZCI3"/>
    <dbReference type="GeneID" id="20321632"/>
    <dbReference type="KEGG" id="ovi:T265_07453"/>
    <dbReference type="CTD" id="20321632"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28527" checksum="0AB0993BDA72C1B6" modified="2014-10-01" version="1">MYAAVRKRHPMKKSHKARLYVRKKSALIVGLNTFKNNPSGHLQLLNPIPDPHRNPRRDPAMKHFLLHLAENLVLGKNFVHTDLDDYHLFIDPDILGKLQEHVDQLMESLSFPMACATAMPPEGSTMAGIPPDCRSLDRVSREAEVGFEPETFWSRHRAHGPDDLPPALVKNEGEVPSQRLSDLFACIWEKESVPDKWGESVLVPVFKTGARNECGNHRGISLTPVVTRLLASIVLRRLTVARETLTREQQAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCN9</accession>
    <name>A0A074ZCN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171236.1">
        <property type="nucleotide sequence ID" value="XM_009172972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCN9"/>
    <dbReference type="GeneID" id="20328461"/>
    <dbReference type="KEGG" id="ovi:T265_14295"/>
    <dbReference type="CTD" id="20328461"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21985" checksum="43E6906052996B7B" modified="2014-10-01" version="1" fragment="single">MTRIPIGWVRWPKWLELKCTDRKVRDLGNLEVSYPSCFLRVAWKLGIGRVLQLNEFSSKYFVFLRICLKIGVIHVGSKNETACWLFNVNRLTLHRLPGSTNLTDFDANSIFMQQTINHDNFPECYMAFVAQLGPFLSHAVSKESKGSHNAIVRLESLGEGSAGWVRLRHEAAWWSTFSCLETSQTRDSTGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCW6</accession>
    <name>A0A074ZCW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171200.1">
        <property type="nucleotide sequence ID" value="XM_009172936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCW6"/>
    <dbReference type="GeneID" id="20321597"/>
    <dbReference type="KEGG" id="ovi:T265_07418"/>
    <dbReference type="CTD" id="20321597"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7698" checksum="524684F6FBEC1D19" modified="2014-10-01" version="1">MVFEDMEAVEIWKETVVEGSVLDKKSSVMQWVWHLNRDYWMRTGGRTDKKRMKQTNPEDDKHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD26</accession>
    <name>A0A074ZD26_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596995">
        <property type="protein sequence ID" value="KER21100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175166.1">
        <property type="nucleotide sequence ID" value="XM_009176902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD26"/>
    <dbReference type="STRING" id="6198.A0A074ZD26"/>
    <dbReference type="GeneID" id="20324682"/>
    <dbReference type="KEGG" id="ovi:T265_10514"/>
    <dbReference type="CTD" id="20324682"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TAP-C" evidence="9">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9121" checksum="F75CC497F7ED39C2" modified="2014-10-01" version="1">MASKATTQPANPAPPTDTTVPSVSSSTPADASAQAILITELKQRSGMNEAFSRQCLEEYQWNFEAAFGAFEMLRNAGKLPPEAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD6</accession>
    <name>A0A074ZDD6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596984">
        <property type="protein sequence ID" value="KER21210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175050.1">
        <property type="nucleotide sequence ID" value="XM_009176786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD6"/>
    <dbReference type="GeneID" id="20324586"/>
    <dbReference type="KEGG" id="ovi:T265_10418"/>
    <dbReference type="CTD" id="20324586"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="47" mass="5160" checksum="72245802C054B7FE" modified="2014-10-01" version="1" fragment="single">GVTHSSVSGVSHDALRRSPTRASRCQSNERILHRVSLLNNKNYANGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEQ0</accession>
    <name>A0A074ZEQ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174553.1">
        <property type="nucleotide sequence ID" value="XM_009176289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEQ0"/>
    <dbReference type="STRING" id="6198.A0A074ZEQ0"/>
    <dbReference type="GeneID" id="20324206"/>
    <dbReference type="KEGG" id="ovi:T265_10038"/>
    <dbReference type="CTD" id="20324206"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55002" checksum="FB843D69602616A2" modified="2014-10-01" version="1">MESSEDRIPIVDNNSISNTSGDPHSRPSISVPNNYVHRVYPVRWAIVLVLAFINGSNAYIWISYAPVANHFCEYYSTTEYVLNWMQLVFPITTVLFGLPASLVVDWLGIRFVLLFSVTTHLICGLARLLSSCSTHWPPTTIRLRLVLFGHVVASLAQPLCMFAPTKLALDWFPDFQRTTANTIGSLGNSVGVLIGSALVPFLVPQPSAIPTFNYITMGLVTFGGVLSVIFVRKNKPETPPSVASAVFEEMHRKHAVTIPMRLQSFVRCVSLAMRSPAFFLLATTFGGGLAYFGAISTLLQQILCTKGYSNEYAGICGSLLIVAGLIASAPCAIYVDRTGRLVESVKVCFVLATLGCVGFSVVIWFPGQSFLTIFFTMWLGAFGFAQYSLALELAAEITFPVPEAITTGLMISFSQILSIVFVAGMQAAAPEVHSSPSFTPTCGSAVTPQDYTVPNLVVCSTLVLIGIIQLFALRVTYKRREASLSFNSQVDAPPNHVQSVIDEMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG33</accession>
    <name>A0A074ZG33_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171629.1">
        <property type="nucleotide sequence ID" value="XM_009173365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG33"/>
    <dbReference type="GeneID" id="20321939"/>
    <dbReference type="KEGG" id="ovi:T265_07760"/>
    <dbReference type="CTD" id="20321939"/>
    <dbReference type="OrthoDB" id="10362402at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="248" mass="28161" checksum="30BDF9A7C9EBCCE7" modified="2014-10-01" version="1">MVRRYILLRFCVKEQMMNDLIHLVGENSVMPPTHNLVLVLLCLATLLLLSVFAKHDKPAVDKAKLSRWLTAKASIHNPPIPPMMGLTFENFVGDYGLKITFQQFQKKYDCYHCTNCDLQRGGKQPVRSGCNECVLITQPDQSSDRLCNQGTTSICKNQKTAYCCQGYLCNFSHPSQRGTDWRLLITQPDQSSDRLCNQGTTSICKNQKTAYCCQGYLCNFSHPSQRGTDWRLVCVVTTGMLIISNYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG60</accession>
    <name>A0A074ZG60_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_06461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169993.1">
        <property type="nucleotide sequence ID" value="XM_009171729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG60"/>
    <dbReference type="STRING" id="6198.A0A074ZG60"/>
    <dbReference type="GeneID" id="20320640"/>
    <dbReference type="KEGG" id="ovi:T265_06461"/>
    <dbReference type="CTD" id="20320640"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="62"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="260"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="791"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="809"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="849" mass="94897" checksum="A2D3C6B7140D9CAE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGA6</accession>
    <name>A0A074ZGA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169968.1">
        <property type="nucleotide sequence ID" value="XM_009171704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGA6"/>
    <dbReference type="GeneID" id="20328200"/>
    <dbReference type="KEGG" id="ovi:T265_14034"/>
    <dbReference type="CTD" id="20328200"/>
    <dbReference type="OrthoDB" id="6253298at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="715" mass="84452" checksum="62F544341B9B2B6C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHQ3</accession>
    <name>A0A074ZHQ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169439.1">
        <property type="nucleotide sequence ID" value="XM_009171175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHQ3"/>
    <dbReference type="GeneID" id="20320198"/>
    <dbReference type="KEGG" id="ovi:T265_06016"/>
    <dbReference type="CTD" id="20320198"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16839" checksum="B0CE5B8307FC1165" modified="2014-10-01" version="1">MIRGAVARKKPGPTPPAHPIEHFAEVYERGSANLTELSNARSNTRRVLLFPHNLSVRCPTCSPRERWTKQLEREFTNRKVHASNLTSASRLSLSRLGKPGSIPALVLPLGSMAARHRKGRTAERLFSTESVHQTCHSKLEKVLPLQILRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIX0</accession>
    <name>A0A074ZIX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596856">
        <property type="protein sequence ID" value="KER23285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172968.1">
        <property type="nucleotide sequence ID" value="XM_009174704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIX0"/>
    <dbReference type="STRING" id="6198.A0A074ZIX0"/>
    <dbReference type="GeneID" id="20322976"/>
    <dbReference type="KEGG" id="ovi:T265_08797"/>
    <dbReference type="CTD" id="20322976"/>
    <dbReference type="OrthoDB" id="6267013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704145" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12242" checksum="2B02F05B5BAC6D05" modified="2014-10-01" version="1">MLYFKVVLTCGLLLGFSMITESLNFKDCGSTDVSVMRVTLSPSSKVPCVIVRGKQSESKLNRDIATELPEIRGSSGHGPQVLQFPEGGIRAHMSPSCPIKARKFYAYFTGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM04</accession>
    <name>A0A074ZM04_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167800.1">
        <property type="nucleotide sequence ID" value="XM_009169536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM04"/>
    <dbReference type="GeneID" id="20318905"/>
    <dbReference type="KEGG" id="ovi:T265_04723"/>
    <dbReference type="CTD" id="20318905"/>
    <dbReference type="OrthoDB" id="6252146at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="40419" checksum="26DE00366151E56D" modified="2014-10-01" version="1">MRFEDNGCVQLVILQRELPTYECASIQTQPPHLSSDYAPKIWKSTSVGKLFEIAQYIFIKETTHKVAEKSSTAHDRFRSSWRSSGPRSFRVSVNLNPNWTVFENHTHFSFQQLFSSSQHSFFGSINSPYSDSLSLFAGWRSYLVLMLCLPKQGIQHKLDTLTPYVRYPEFEPRHGRGHALLLSPEEGTRAGILPGCASLDRGSREAEVGFKPRTFQSIDSPSSLCNQYGLLVAENSSTAHNLFRPSWNLSVRRSPRVFVNLMFYLKPNCTKLVKCINLQIAHCVGQGLHCKTCVRNKTFYVKILHFVAYEHKPKSIIISARIFAAHRITLSAEANIPLAGKFCWNTFLTSLIPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMG1</accession>
    <name>A0A074ZMG1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tropomodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171711.1">
        <property type="nucleotide sequence ID" value="XM_009173447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMG1"/>
    <dbReference type="STRING" id="6198.A0A074ZMG1"/>
    <dbReference type="GeneID" id="20321997"/>
    <dbReference type="KEGG" id="ovi:T265_07818"/>
    <dbReference type="CTD" id="20321997"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40285" checksum="9841F4FB0B200DD9" modified="2014-10-01" version="1">MSNKLLFGKELASYDDEDLDELLSKLTEEEIQQLNDDLDPDNTLLPPSQRCRDQTTKAPTGPFNREKLLKFLIDKAKSEKDWEEAVPYEKVTRGKVYIPKQEQVQVSQKELSDMGFDVEFDQEVNEALENATEDELVDLAAVLGFTGMMNQVQFYASLENRKLEGGGFTGVAKGDRPKPVPDEPPNTTDVEESITRLGKNDPELTDLNLNNIKTMSAEVVKRLSDALKTNTKLRKLKMASTALTNVMIEPIIEMLQSNSTLEELNLESNFITGPHLVKLIEAINHDKSAITELHLSNQRQTVLGIAIEQMLTKTILENPRLVRLGLDLDTSEARVRVREHIKTNLDRASRQARRTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN24</accession>
    <name>A0A074ZN24_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sedlin, region</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171540.1">
        <property type="nucleotide sequence ID" value="XM_009173276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN24"/>
    <dbReference type="STRING" id="6198.A0A074ZN24"/>
    <dbReference type="GeneID" id="20328520"/>
    <dbReference type="KEGG" id="ovi:T265_14354"/>
    <dbReference type="CTD" id="20328520"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16396" checksum="3F1E6493E7E3EDD6" modified="2014-10-01" version="1">MVGRYYFAIVGREDEALFDFEYSTNKGNGQKFEELRYLNQFIAHASLDVIDDQMWTANGTYLKSVDKFNEWIVSAFVTPGQLRMVLLHDEPNDTRIRNFFNDVYEAYVKLALNPFFDRAKPITSPSFTKKMQRLTSKHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN39</accession>
    <name>A0A074ZN39_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171475.1">
        <property type="nucleotide sequence ID" value="XM_009173211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN39"/>
    <dbReference type="GeneID" id="20321817"/>
    <dbReference type="KEGG" id="ovi:T265_07638"/>
    <dbReference type="CTD" id="20321817"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27134" checksum="8E606BD61ED66D39" modified="2014-10-01" version="1">MTQSAGAGSSHWRSTDFYSGNSKLSHYEQFQDFDSSVITNTLQDSWQCPSQRQQTISVVELSQITGISMAWINVVGLAIHPNASANVPQARAISLLISRGRRQLQISGKAIEWKRQALTGELTNLRRAFALQALQQTCLVRLSLEELGDTRPRKRTACLNGEQRYAMSHHTADQALVAERFSLQPLAGRSLEIREMHAADESEHVSWPPYHHPTLWQLDDYQLIEFKGGNEIQLVYTLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNM2</accession>
    <name>A0A074ZNM2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168867.1">
        <property type="nucleotide sequence ID" value="XM_009170603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNM2"/>
    <dbReference type="GeneID" id="20319744"/>
    <dbReference type="KEGG" id="ovi:T265_05562"/>
    <dbReference type="CTD" id="20319744"/>
    <dbReference type="OrthoDB" id="6243977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="226" mass="24970" checksum="64E19D2F85369995" modified="2014-10-01" version="1">MHRQLPSLGTPCMSEHREFVKMQYGRKIAQDTCMLATMRTPDWPQAPPGCIGRHNSVPCTVTTNSSSSNVRMYPYSVYTSSCHPDPHRCPKLRNGCSRHRCLSGSALQGLVPSTSADATEIQRALLRSHIAETNSKAALFRSIPLSNLVLQHSVTRYPSGRPASHLYQHSIHPTNHHHSLDQTAACLPGHSIGGAQSVVHLGFQPFPDPTSHSQRSIFTTDLLQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPD1</accession>
    <name>A0A074ZPD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596785">
        <property type="protein sequence ID" value="KER25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171083.1">
        <property type="nucleotide sequence ID" value="XM_009172819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPD1"/>
    <dbReference type="GeneID" id="20321506"/>
    <dbReference type="KEGG" id="ovi:T265_07327"/>
    <dbReference type="CTD" id="20321506"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="51954" checksum="7E5D8DDC2DDC5844" modified="2014-10-01" version="1">MGPSSGIEDRIGFGTGKYSGPLVVVNAEPFPTATAMRLANCNWVEKSLVVTAGRGNGPKEANNEESVGINPEGMRDVNPTRDSAINEGKETATLGKLSGVLKPSNVPEVNGCACGLRVGFGSTVVGKRVVLDRGDRLCVGEESGNVYTLAGSLLVLGKYRDVDLGARWPPERLGSGFAENLENCFVFCGLREVSDENDKRLLDEVARRHIWLDCDVTGLTVFGTVGFTILSLELRVPLPIAGVTEQAEAGFVHVEMGVNTILGGDEVAEEPDPTGVHGRIGEAGDRSIGVDERRGGKRRPGELGASAALLTAASVASKSKTDVELDGSMSTAELGSDLVTTGSSSEEAGGNEELNSGVGDGLVLKEELVMVDSSVMVLNSRTSGVASTCDARGSVETSNIEFGATFSSAQPVAPSLAYEETTTPCRLGCRSLDSVLGRHQRTSSCLLPLLGSIYTRGLWEPEIAQWLGRETTDWKVHGSNSIQTSRLLLTRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ89</accession>
    <name>A0A074ZQ89_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein assembly factor 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166623.1">
        <property type="nucleotide sequence ID" value="XM_009168359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ89"/>
    <dbReference type="STRING" id="6198.A0A074ZQ89"/>
    <dbReference type="GeneID" id="20317975"/>
    <dbReference type="KEGG" id="ovi:T265_03788"/>
    <dbReference type="CTD" id="20317975"/>
    <dbReference type="OrthoDB" id="538817at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="492" mass="56504" checksum="D8AD07DA5A0D2130" modified="2014-10-01" version="1">MLQLYTAFESNHRLNLQDKTETFLELFGNTLLRENVATYLRHVASEFIRYDFVGRNKLDPPKLFDRIVTSFDSGDENLSFIDLSNLKFKERDILESIFKFWRKSDTKEFEINKIWDYRLRKHLGTRYDAIPNVFDWDCSITLHDRKAEQIDSREYSRWRQCGMAFELRQADYIVPNRSLASGRSFKTPKGETSIYWGYWGDITTSPYITLGIRTDNHPELARQVNGKRVYGATTVAEVNVREMLWRLEHHRECPKKIAAPFLNNKQDEKQSGDTEDTTGTENEGENFQLVDENHGESANTKVVTFSGGDISNMASFETHLRETPYVPVQPSVPVTVKYLPVNSFPDLPTRYQSIILGENPHPIDIIYVGCGLVQLLDSANLKPVHNSRFPEAALSDDTINPKEQTSPNPKDRQFTESEPCTGLMALLSSKAILIVESVLYIVELRPAEIEAYVERVTKMASELGFKPSKKHEPMKDYHLIFVRDSDGTKSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQA1</accession>
    <name>A0A074ZQA1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166630.1">
        <property type="nucleotide sequence ID" value="XM_009168366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQA1"/>
    <dbReference type="GeneID" id="20317982"/>
    <dbReference type="KEGG" id="ovi:T265_03795"/>
    <dbReference type="CTD" id="20317982"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="10937" checksum="246EE6173650A826" modified="2014-10-01" version="1">MKCRTQYVGSHEPPELRKSSHPQVAKEVQHSTVSRNKRLAVTSFRCLAVMLPEGGTMARLLSGCPSLSGGSRGTEVGFEPQTSRLVNSRSNHLSHLTPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS54</accession>
    <name>A0A074ZS54_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166008.1">
        <property type="nucleotide sequence ID" value="XM_009167744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS54"/>
    <dbReference type="STRING" id="6198.A0A074ZS54"/>
    <dbReference type="GeneID" id="20317485"/>
    <dbReference type="KEGG" id="ovi:T265_03298"/>
    <dbReference type="CTD" id="20317485"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59848" checksum="F76703E7D343B45F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSC5</accession>
    <name>A0A074ZSC5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein kinase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_06456</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169988.1">
        <property type="nucleotide sequence ID" value="XM_009171724.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZSC5"/>
    <dbReference type="GeneID" id="20320635"/>
    <dbReference type="KEGG" id="ovi:T265_06456"/>
    <dbReference type="CTD" id="20320635"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11623">
        <property type="entry name" value="HR1_PKN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05589">
        <property type="entry name" value="STKc_PKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000058">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000038">
        <property type="entry name" value="serine/threonine-protein kinase N2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="REM-1" evidence="15">
        <location>
            <begin position="260"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1316"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="845"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1085"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER26260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1383" mass="154871" checksum="394C3B41EE63EF3E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSQ9</accession>
    <name>A0A074ZSQ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TDD superfamily. DTWD2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166152.1">
        <property type="nucleotide sequence ID" value="XM_009167888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSQ9"/>
    <dbReference type="STRING" id="6198.A0A074ZSQ9"/>
    <dbReference type="GeneID" id="20327405"/>
    <dbReference type="KEGG" id="ovi:T265_13238"/>
    <dbReference type="CTD" id="20327405"/>
    <dbReference type="OrthoDB" id="408541at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF0">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="7">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="247" mass="28350" checksum="443348F998CF3B6E" modified="2014-10-01" version="1">MDEPFEELCSVEAEPSREPKRAMCKNCLRPLSSACWCPWLPQSRLPIQTNILILQHPYEERRKVRTARILELALSEQRVRLVRGRKFNEQRCPELMPILTSDNTFVLFPYRGAIPADQCCPQADDVPGSRWLVVLDGTWTQARHMLTGSPLLFALKRVCLPPNPTTGDVIPSEFIVRRQPFSHAVCTVEAVARILDLWEPRDPARSNKFYQTQLLRPLYRICEVQTAWKTDEKKGESDVFCNGDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT62</accession>
    <name>A0A074ZT62_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165946.1">
        <property type="nucleotide sequence ID" value="XM_009167682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT62"/>
    <dbReference type="GeneID" id="20317436"/>
    <dbReference type="KEGG" id="ovi:T265_03249"/>
    <dbReference type="CTD" id="20317436"/>
    <dbReference type="OrthoDB" id="10517745at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="21848" checksum="902B9596234C4DAB" modified="2014-10-01" version="1">MSMHYQCSAAKQLTAPKNYPDMSPSILRCLGEVANQALPGEQIYRRNASTVREIFCDEGFQIRNATIQPVRLLGSAEAVLALAWGRVEDGAREIEASAVICVQLPALIYAPRKATSPAIPRDGRCDVEALLAVIIAVVDDELAVEPEDVFSKDFKSFFAKCSNCTQIAANQLQKLDWIFEQCKDTYGDFTKLLNSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW1</accession>
    <name>A0A074ZTW1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165311.1">
        <property type="nucleotide sequence ID" value="XM_009167047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW1"/>
    <dbReference type="GeneID" id="20316920"/>
    <dbReference type="KEGG" id="ovi:T265_02732"/>
    <dbReference type="CTD" id="20316920"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="20953" checksum="E3899AFF83E75939" modified="2014-10-01" version="1">MPGSGDRERSLRELQLREVRPGTEPDKTQFREMSRLSGTEVGQDKTVALSLLRCTAVLGTAVTVGLVAHVVDDILVIDFDLDFRLLFSGCLGVVVTDGECDLAANHTLVPKASMVSPVYNVASVLACRWDHKACLFALPAARRMIMFLSEPAKQMTESGLASALSGLFNSNWAMHSDYNRGSEIVFLDKCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU28</accession>
    <name>A0A074ZU28_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KL598635">
        <property type="protein sequence ID" value="KER18694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177559.1">
        <property type="nucleotide sequence ID" value="XM_009179295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU28"/>
    <dbReference type="STRING" id="6198.A0A074ZU28"/>
    <dbReference type="GeneID" id="20330051"/>
    <dbReference type="KEGG" id="ovi:T265_15886"/>
    <dbReference type="CTD" id="20330051"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER18694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13876" checksum="C23D0F1B6218690E" modified="2014-10-01" version="1">MGRIFIEHLGGEKVFHCRRCGVPLSNDSEIVSTRFNGSSGRAYLFNRVVNISYSEIQDRIMLTGRHLVRDVMCIKCNTKLGWTYEHAVERNEIYKEGRVILEEALFVESDGIADPLGERVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV74</accession>
    <name>A0A074ZV74_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ashwin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168998.1">
        <property type="nucleotide sequence ID" value="XM_009170734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV74"/>
    <dbReference type="GeneID" id="20319851"/>
    <dbReference type="KEGG" id="ovi:T265_05669"/>
    <dbReference type="CTD" id="20319851"/>
    <dbReference type="OrthoDB" id="6252411at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22579" checksum="42BAED1087377335" modified="2014-10-01" version="1">MKGCEADDLVVREYLPQNSVHVDLLQPELMTPSDLLALFERRGLGFLVSKSDPFHRLVDLYYDHLMPMPMRAASPDLTTVPSVQRIKPPAAPESQTATPKLTVKRKADEVQLDSLVIKHNPNWTTPGETVRSDERVLSVKKPKSFDTLGQNHVNHSRNSTTAQACPTATKTATNGSNCTRVNSSPGTDSCKKRVKLKRDFTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVC8</accession>
    <name>A0A074ZVC8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166447.1">
        <property type="nucleotide sequence ID" value="XM_009168183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVC8"/>
    <dbReference type="STRING" id="6198.A0A074ZVC8"/>
    <dbReference type="GeneID" id="20327462"/>
    <dbReference type="KEGG" id="ovi:T265_13295"/>
    <dbReference type="CTD" id="20327462"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18013" checksum="B5FF4757CEB1DA92" modified="2014-10-01" version="1" fragment="single">MRTRRTLRGHLAKIYAMHWSTDSRNLVSASQDGKLIVWDGYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFIDDSQIVTSSGDVTCGLWDIETGQQIANFTGHTGDVMSLSLAPDNRTFVSGACDASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVK5</accession>
    <name>A0A074ZVK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164745.1">
        <property type="nucleotide sequence ID" value="XM_009166481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVK5"/>
    <dbReference type="GeneID" id="20316465"/>
    <dbReference type="KEGG" id="ovi:T265_02277"/>
    <dbReference type="CTD" id="20316465"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8554" checksum="438677027104A87B" modified="2014-10-01" version="1">MRTEAPTSSLTVERWKPLIPVMSKSNPELFDQHKGKRNIASQLRTDYVVRNARFMYSTYKRQIVHTSRGNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVT1</accession>
    <name>A0A074ZVT1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164706.1">
        <property type="nucleotide sequence ID" value="XM_009166442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVT1"/>
    <dbReference type="GeneID" id="20327121"/>
    <dbReference type="KEGG" id="ovi:T265_12953"/>
    <dbReference type="CTD" id="20327121"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="343" mass="38242" checksum="0D7CCAE56355BE46" modified="2014-10-01" version="1" fragment="single">MSEEKFFRDQNGAPRTRRIPKSNLQATMSEENPESFIMQALNPDLPADLPLKTKGIITLPTVKEVVKHVFKAPNAVGLRVEAASISKPFQIRFDPSITQDDIMATELNDKSRISMLSLAFMYDTGPAGAERITWGYAAGDEFLSTTCDEFMKLQKKAGKSIAPFCGWEQYNLPSCLPDHSGFGLCDIRGSTESNFEPPELNVQLKLRTYSGPEHPDKRCPIIKRSPDIRLANRLSDQCKLHTKQHPQENYALEYFGSSSICVDHNRQAPLIFSKGVESISLDLYGASCHYHVCEPMFGLRIHFGNKFVYCPLEGGPIMVEVNHGKIGNLRGSINCPPCPKVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW74</accession>
    <name>A0A074ZW74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164923.1">
        <property type="nucleotide sequence ID" value="XM_009166659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW74"/>
    <dbReference type="STRING" id="6198.A0A074ZW74"/>
    <dbReference type="GeneID" id="20316614"/>
    <dbReference type="KEGG" id="ovi:T265_02426"/>
    <dbReference type="CTD" id="20316614"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="20058" checksum="1EC251D43C3E47E1" modified="2014-10-01" version="1">MKEITKRLSDVGATRLPGWGRVILTVPGWRHYKIWLPTDVSGVRVVSFCPDCLNRPKLISTGKGCVKRDESILCGVTVASKSCAQWSGIGFTCAWLEKVRDVASNRCQWRFYCQIARVFTRDSTESLVYDIFHLNSQYKGRFIFQLVRYSIYHSIFSLRKLPTKLLLKSLKQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWA2</accession>
    <name>A0A074ZWA2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168614.1">
        <property type="nucleotide sequence ID" value="XM_009170350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWA2"/>
    <dbReference type="GeneID" id="20319541"/>
    <dbReference type="KEGG" id="ovi:T265_05359"/>
    <dbReference type="CTD" id="20319541"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9489" checksum="C2F89642835D8F75" modified="2014-10-01" version="1">MSTSPQMEESTGRLLADFQRENITLEKKLEKPPVMNRKNGECTGTTILCTHQSALMKLSTYREESKHQDLELGLSAAHTPVTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWH7</accession>
    <name>A0A074ZWH7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MLX-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164454.1">
        <property type="nucleotide sequence ID" value="XM_009166190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWH7"/>
    <dbReference type="STRING" id="6198.A0A074ZWH7"/>
    <dbReference type="GeneID" id="20316230"/>
    <dbReference type="KEGG" id="ovi:T265_02042"/>
    <dbReference type="CTD" id="20316230"/>
    <dbReference type="OrthoDB" id="6086776at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="93217" checksum="2B5DD0C7059B959C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXY5</accession>
    <name>A0A074ZXY5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_01537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163860.1">
        <property type="nucleotide sequence ID" value="XM_009165596.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZXY5"/>
    <dbReference type="GeneID" id="20315725"/>
    <dbReference type="KEGG" id="ovi:T265_01537"/>
    <dbReference type="CTD" id="20315725"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001143">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000007">
        <property type="entry name" value="Dynein heavy chain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000009">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001145">
        <property type="entry name" value="Putative dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1481"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1762"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2107"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3573"/>
            <end position="3597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="893"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3020"/>
            <end position="3057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="3573"/>
            <end position="3589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="4359" mass="497736" checksum="2640466A7DADCCA8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY03</accession>
    <name>A0A074ZY03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_01556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163879.1">
        <property type="nucleotide sequence ID" value="XM_009165615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY03"/>
    <dbReference type="STRING" id="6198.A0A074ZY03"/>
    <dbReference type="GeneID" id="20315744"/>
    <dbReference type="KEGG" id="ovi:T265_01556"/>
    <dbReference type="CTD" id="20315744"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15621" checksum="D72C08EE97E721CB" modified="2014-10-01" version="1">MPKYYCDYCDTYLTHDSPSVRKTHCGGRNHKDNVRDYYQKWLEEQVQKLVDHTSEAYKQGKMPPPLFGSPLGMPPPGLAYPPRFPPVAVPPGYRGPTPMVPPQGMMMPPRVGMPGMPGMPGMAGWPPAPTGAAMPPYTAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY41</accession>
    <name>A0A074ZY41_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168015.1">
        <property type="nucleotide sequence ID" value="XM_009169751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY41"/>
    <dbReference type="STRING" id="6198.A0A074ZY41"/>
    <dbReference type="GeneID" id="20319073"/>
    <dbReference type="KEGG" id="ovi:T265_04891"/>
    <dbReference type="CTD" id="20319073"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="2">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="2">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="357" mass="39037" checksum="82DC636B191AF600" modified="2014-10-01" version="1">MTEVQAQPSSASEQKYGGAEGADAMYVKLVSSDDHEFYVRREYALISGTIKAMLSGPEVQAQPSSASEQKYGGAEGADAMYVKLVSSDDHEFYVRREYALISGTIKAMLSGPASARPSSVTTLNTSKSVFKPRKPVYLATFNVRTLKQAGQQVAFARTLDSLCIDVCCLSETRTQYASVVIKQTAPSLSYRFRLRTSGDAKAAVAGYAGIPVDSRLCAGRLATLVRESRGSEVHRTLFIVSAYAPTACSSESGRDSFYDALDALQQQAKSSDIVVVAGDMNAQVKVNVRADQGAWWIRKAQEMEDAKNTGDVRKLFHLIRSTDPRKPLVSEIIRDQNGSLKCSKAERLACWAQYFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYA8</accession>
    <name>A0A074ZYA8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163806.1">
        <property type="nucleotide sequence ID" value="XM_009165542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYA8"/>
    <dbReference type="STRING" id="6198.A0A074ZYA8"/>
    <dbReference type="GeneID" id="20315689"/>
    <dbReference type="KEGG" id="ovi:T265_01501"/>
    <dbReference type="CTD" id="20315689"/>
    <dbReference type="OrthoDB" id="2119217at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="37913" checksum="01BD25DBD1DD4B5F" modified="2014-10-01" version="1">MPVDKPYDETIDVPDSEDIVTPRSRRSPQGTMDEYEDRETKPKKRAVQGGEGQFTVTPPAGPSLLSGMKSSRLTGANEGERGGGLSESATSDDDEDDDDDDDDDDEDNTPEVIEGAYNPADYEHLTVSPEIKEMFEYIQRYTPQIIDLETHLKPFIPDYIAAVGDIDAFLKLRRLATSYNAKSSYIDQVPRPDGKPDNLGLLVLDEPCANQSDPTVLDLHLRALSKQSASKEITVRSIENAEQQTKAIDNWIKSITNLYRAKPPPTVHYVRNMPEISTLMSEWPSKFEEVMKKLRLPSSELDCSLKEYVDIVCGPWFSQQVLLSLGCYASHFPKTNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYL5</accession>
    <name>A0A074ZYL5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165206.1">
        <property type="nucleotide sequence ID" value="XM_009166942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYL5"/>
    <dbReference type="STRING" id="6198.A0A074ZYL5"/>
    <dbReference type="GeneID" id="20316832"/>
    <dbReference type="KEGG" id="ovi:T265_02644"/>
    <dbReference type="CTD" id="20316832"/>
    <dbReference type="OrthoDB" id="27389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="476"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="752" mass="85008" checksum="6F5B352BF3846B32" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZK1</accession>
    <name>A0A074ZZK1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163679.1">
        <property type="nucleotide sequence ID" value="XM_009165415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZK1"/>
    <dbReference type="STRING" id="6198.A0A074ZZK1"/>
    <dbReference type="GeneID" id="20315577"/>
    <dbReference type="KEGG" id="ovi:T265_01389"/>
    <dbReference type="CTD" id="20315577"/>
    <dbReference type="OrthoDB" id="515366at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF19">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="168"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="344" mass="39604" checksum="3A9600559AC7089B" modified="2014-10-01" version="1">MNPAYDSALLAILQHEGKIEKFLDVIFGFLMRRTDFYHIMTVEQKKLGFPPGVNLRMVLQAFERYKSMFEEYNRQHMEAVAEKVQSTKSKKQAISRRPPTVDRKTTETASADNFVVPVPDSTQETTAATEEKHSPGDSKPTEQTSTRESTEEEGPLVYQADPDCYNGAERENYTWSQSIKDVDIKVKVPNRIKTGRDLKIAIDRKHIRIVLVPSGNEEPYFYRELCWEISTDDAVWTFDPEEGQVQFCLDKVEERWWDAAFEGEDKINTRKIDCSRPMHELDEESQAKIHQLMYDQECKRKGLPTSEEKKVHDILAKAWDVEGSPFRGTPFDPSKINVGPSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZX0</accession>
    <name>A0A074ZZX0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167417.1">
        <property type="nucleotide sequence ID" value="XM_009169153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZX0"/>
    <dbReference type="GeneID" id="20327673"/>
    <dbReference type="KEGG" id="ovi:T265_13506"/>
    <dbReference type="CTD" id="20327673"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="18666" checksum="A0B5AA6B0FD55433" modified="2014-10-01" version="1" fragment="single">THLRPATFRLLVEHFTFDYERLNRSVIGARSTVAPFWCLTAITPEGSMRAWILPSCPSPNRGSREAEVGFEPRTFHPPGIRQYFTMQKRNISYATFGANTVHADMELPQCVQHSSLSKPPFLGKTQVPHCKEKSKGGQGRDLRLASHDQSEVPTPPDIHSGNLDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZY9</accession>
    <name>A0A074ZZY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.320</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein midA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_01323</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 13">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="5"/>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163593.1">
        <property type="nucleotide sequence ID" value="XM_009165329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZY9"/>
    <dbReference type="STRING" id="6198.A0A074ZZY9"/>
    <dbReference type="GeneID" id="20315511"/>
    <dbReference type="KEGG" id="ovi:T265_01323"/>
    <dbReference type="CTD" id="20315511"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="15">
        <location>
            <begin position="383"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="966" mass="108884" checksum="1087E73A9EAE5C16" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A062</accession>
    <name>A0A075A062_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163173.1">
        <property type="nucleotide sequence ID" value="XM_009164909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A062"/>
    <dbReference type="STRING" id="6198.A0A075A062"/>
    <dbReference type="GeneID" id="20315182"/>
    <dbReference type="KEGG" id="ovi:T265_00994"/>
    <dbReference type="CTD" id="20315182"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="276" mass="31200" checksum="A4E258ECEA9075EE" modified="2014-10-01" version="1">MEEAREELEDFQISSRELERELEIQLGQLEKQNEALILSNEKLISERDQLRERLDSGQNNANSELTKLQEELARYKNEKEQQQRYIREMEQRNDDLERANRATVVSLEAFELQLNEAIEHNAILENELDEKKDLIVTVQRLKDETRDLQQELAVIRRQPASHSASFSNGHLNDVSAPSKHSTEIMVQTEPYSVPAPLLTPSTRIAALNMVNDALQKIGLYRSYGAPPLSAPPNAFVPPALPGSPFGGTLNGGSGKMPNSHSYQRRGSLRSWTNGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0L7</accession>
    <name>A0A075A0L7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167126.1">
        <property type="nucleotide sequence ID" value="XM_009168862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0L7"/>
    <dbReference type="STRING" id="6198.A0A075A0L7"/>
    <dbReference type="GeneID" id="20318366"/>
    <dbReference type="KEGG" id="ovi:T265_04180"/>
    <dbReference type="CTD" id="20318366"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="295" mass="33217" checksum="E70701D0AB6B9EF7" modified="2014-10-01" version="1">MSCGDKNKPSDSAHVSLFPSPPWQLVTKHHSPSSESPVRPPTPPGTNVYRMFGNLYNLDDAILRSLESQGVRRVYPQTYNRKRELRKINFSILANYLDLLDIITRDPSSTKRTERLDNLAVLFINMHHLVNEYRQHQARDLLREILKYQVTVASQTVEKAEQYMTRADEILRNAGCDLVLPNQSSGLPTNVPSTLPTNYIDTVRSGLSDLGPSLAPLLQTVLDETMGVDPTGRRGSLPSTQRGGISLLEQRLCENSKPSSTEEYELAEHLDPILWRFLTLSKLGDPSQDDFSMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A104</accession>
    <name>A0A075A104_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164267.1">
        <property type="nucleotide sequence ID" value="XM_009166003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A104"/>
    <dbReference type="GeneID" id="20316065"/>
    <dbReference type="KEGG" id="ovi:T265_01877"/>
    <dbReference type="CTD" id="20316065"/>
    <dbReference type="OrthoDB" id="10386678at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28945" checksum="18EA800EB74B2DC6" modified="2014-10-01" version="1">MKTLPPALMFEPTLVGWHRQSYKLSTCIAHCAFVTLWLPAHSMGSTLSRIFHRKQDDEAKPKVKKPRRFGSLRRQRTDDQETGTRVSRSSTMPSRTQRVRTEDRSTGLIGETAEEVQRLEDRQEIMRDVMDYDETVTPVAAQHLSAQMPHVEPSHVPEHKEVVPEIKAELPGGFAAVQLVSVTSNDKAVEDVPELSPMTEALHEEEDEPVILNAEDLRQEHEEHTEHIEQKVSREQNIEPIMELEIDTGTRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1R4</accession>
    <name>A0A075A1R4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_03877</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166733.1">
        <property type="nucleotide sequence ID" value="XM_009168469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1R4"/>
    <dbReference type="STRING" id="6198.A0A075A1R4"/>
    <dbReference type="GeneID" id="20318064"/>
    <dbReference type="KEGG" id="ovi:T265_03877"/>
    <dbReference type="CTD" id="20318064"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000073">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000152">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER29500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="367" mass="42270" checksum="34233FE81B2F4C1D" modified="2014-10-01" version="1">MYPSWLPVVRASAIAWTPLIQCELPEGPTFSSNVITRDRKIVINVSGSRFETWKSSLDRFPDTLLGSDEKDYFRDSKSGEYFFDRDPNLFRFILAYYRSGKLHFPKDSCVTAYHDELIYFGIMPEIMGDCCYEEYLDRYRENRERQLEDLNDHKEEEQPATCFREQLWRAFENPQASTLAIVLYYVTGFFIGVSVLANVTETVSCGTSQETGDNIPCGEKYNAAFFCLDTACVMLFTVEYFARLYAAPSRWKFIRSVMSIIDIAAVLPYYIGLFMSNNKEFSGAFTTLRVFRVCRIFKFSRHSKGLRILGCTLRCCASELGFLLFTITMGVIIFSTIMFYAEKSETSQFNSIPAAFWYTIVTMTTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2F2</accession>
    <name>A0A075A2F2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162417.1">
        <property type="nucleotide sequence ID" value="XM_009164153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2F2"/>
    <dbReference type="GeneID" id="20326685"/>
    <dbReference type="KEGG" id="ovi:T265_12517"/>
    <dbReference type="CTD" id="20326685"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00010">
        <property type="entry name" value="tRNA translation"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14426" checksum="20635A9DA8F0BC89" modified="2014-10-01" version="1" fragment="single">SHYTNLKIRGSNPTSVYRLILSRLGPPSSIPALEPPTVGMEAGHRKGATTERLDLIISRRVIRKMEHQTIPLHSYDKYKVTQAAQWLEHWSCKPGVGSSILPGGSPLFVSKTVPGALPSSRIRTRGLSDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3G2</accession>
    <name>A0A075A3G2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163521.1">
        <property type="nucleotide sequence ID" value="XM_009165257.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A3G2"/>
    <dbReference type="GeneID" id="20315460"/>
    <dbReference type="KEGG" id="ovi:T265_01272"/>
    <dbReference type="CTD" id="20315460"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1436" mass="160204" checksum="65193DFDF41767AA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3Z1</accession>
    <name>A0A075A3Z1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163291.1">
        <property type="nucleotide sequence ID" value="XM_009165027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3Z1"/>
    <dbReference type="STRING" id="6198.A0A075A3Z1"/>
    <dbReference type="GeneID" id="20315272"/>
    <dbReference type="KEGG" id="ovi:T265_01084"/>
    <dbReference type="CTD" id="20315272"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8103" checksum="D791CEEF1713507E" modified="2014-10-01" version="1">MKDVERLVRKIALDFKKGLHFQSSAVSAPQEASEVYLVGFFEDTNLCATHDKGVTITPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Z9</accession>
    <name>A0A075A4Z9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162811.1">
        <property type="nucleotide sequence ID" value="XM_009164547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20314886"/>
    <dbReference type="KEGG" id="ovi:T265_00698"/>
    <dbReference type="CTD" id="20314886"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="101677" checksum="7A069792DCEB631F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A544</accession>
    <name>A0A075A544_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162894.1">
        <property type="nucleotide sequence ID" value="XM_009164630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A544"/>
    <dbReference type="GeneID" id="20326789"/>
    <dbReference type="KEGG" id="ovi:T265_12621"/>
    <dbReference type="CTD" id="20326789"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16147" checksum="7B9ACABA4C765FDA" modified="2014-10-01" version="1" fragment="single">MTAVGRSKIRRESRSVTTFVLREIVQLLAFVVYDIQPKNVYAVGKIRKFLMKKDTKQYIFGLVGYPGKLTADGSLPCILLSALTHPRGCKPLLGYSVGKLSSAVKLLRGHQMPRYPPDRWEDYTPLGVPVKGTRLLPIRLPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5J4</accession>
    <name>A0A075A5J4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162767.1">
        <property type="nucleotide sequence ID" value="XM_009164503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5J4"/>
    <dbReference type="GeneID" id="20314863"/>
    <dbReference type="KEGG" id="ovi:T265_00675"/>
    <dbReference type="CTD" id="20314863"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="23338" checksum="F60A896D4ADEEB38" modified="2014-10-01" version="1">MIAQTRVSLQCHVEILIAKTDQKPDCSAPGISKGCRCLANDIFRALLKSGGNTRSAMLNPLTDLYLCTHAQLSTPPPQIIGRRNCRRFIHCTIRSRSLQPITIIMMGVWRIFGLGVRIFFENSCVTDICRMDIIVAALMDPKKDGVIQRLQRKCNFTHESHLAPAILRLRNTLICKSVWVFGELTWNPAQSLDRVVFEKLNVPHQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6Q3</accession>
    <name>A0A075A6Q3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162280.1">
        <property type="nucleotide sequence ID" value="XM_009164016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6Q3"/>
    <dbReference type="GeneID" id="20326660"/>
    <dbReference type="KEGG" id="ovi:T265_12492"/>
    <dbReference type="CTD" id="20326660"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16325" checksum="5BA678EC8B4D91D9" modified="2014-10-01" version="1" fragment="single">MTPLEALQTADFYLLWASVCCVLVPQTMLSSLSKFFGLEYIRDDSFLAGITMASSVCNAVGRVIWGLLGDYLSFKVPLCCLLLVWTILLVTFPHLSGFEGSLLKGLYALWVCLMFFCLSGVFVFTPLASNALYGSRNMTINFGLIYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8I7</accession>
    <name>A0A075A8I7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596834">
        <property type="protein sequence ID" value="KER23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172442.1">
        <property type="nucleotide sequence ID" value="XM_009174178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8I7"/>
    <dbReference type="GeneID" id="20322563"/>
    <dbReference type="KEGG" id="ovi:T265_08384"/>
    <dbReference type="CTD" id="20322563"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8262" checksum="64FF0BF4E16DE187" modified="2014-10-01" version="1">MNFEPFAPEVDWILIVIVILLGFIVLAAIIVPTAVCIRRKWRIKRLQRAKLRSEINPEPGETGVEPMDYEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9G5</accession>
    <name>A0A075A9G5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163926.1">
        <property type="nucleotide sequence ID" value="XM_009165662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9G5"/>
    <dbReference type="GeneID" id="20315791"/>
    <dbReference type="KEGG" id="ovi:T265_01603"/>
    <dbReference type="CTD" id="20315791"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7365" checksum="B7D4AA7EE11D9C90" modified="2014-10-01" version="1">MPLFGLIVYLLLYGSSPHLRKIIDLAKFKVPITRNSVDASDFTDEPDEGGILRPNAYTDQMPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABI0</accession>
    <name>A0A075ABI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171254.1">
        <property type="nucleotide sequence ID" value="XM_009172990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABI0"/>
    <dbReference type="STRING" id="6198.A0A075ABI0"/>
    <dbReference type="GeneID" id="20321640"/>
    <dbReference type="KEGG" id="ovi:T265_07461"/>
    <dbReference type="CTD" id="20321640"/>
    <dbReference type="OrthoDB" id="5825849at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278">
        <property type="entry name" value="CHCHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31278:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="14753" checksum="EAE1C8003860FF6D" modified="2014-10-01" version="1">MKMSTACQRLYKRSTTRFPHMEHYKYDYYREPVLKDKVSGRGEKEPRAVCVGEMTVMLSCLKNHDFDEAPCTQLIDAFKACVQVAEAKRAKDRELRRSGVLEPGDEETRRLPASQVTKLLQRFPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABT6</accession>
    <name>A0A075ABT6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171103.1">
        <property type="nucleotide sequence ID" value="XM_009172839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABT6"/>
    <dbReference type="GeneID" id="20321519"/>
    <dbReference type="KEGG" id="ovi:T265_07340"/>
    <dbReference type="CTD" id="20321519"/>
    <dbReference type="OrthoDB" id="6255700at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15642" checksum="3BFFABDCD49E778B" modified="2014-10-01" version="1">MKSSATPLFHLCLSGERQPLTDKNKTVTGNLSKFLHPVYQSVNPNRDAQTELCPGGCGLHSSCKKVYSGVYTCVCDLMYAPKGSNPRSERVCQLSVATITITVVFGLLIVALICAMIFIIIRGCERKRLDYAKMARDVNKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC96</accession>
    <name>A0A075AC96_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="10"/>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162712.1">
        <property type="nucleotide sequence ID" value="XM_009164448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC96"/>
    <dbReference type="STRING" id="6198.A0A075AC96"/>
    <dbReference type="GeneID" id="20314808"/>
    <dbReference type="KEGG" id="ovi:T265_00620"/>
    <dbReference type="CTD" id="20314808"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="349" mass="38845" checksum="2B8864791343A45F" modified="2014-10-01" version="1">MDKKSIYFVDVGCGNGLLVFVLLNEGFNGTGVDIRKRKIWSSYPDSVQNRLLETTLDAEQCPGFPDATWLIGNHSDELTPWIPVLAARSGPDCKVFLLPCCPFSLFGKYNNFTHYPNEQESTSVSASVEVQSRYRVYLRYLHGLFRVCGFEPESDVLRIPSTKRACLVGRKLSPSSSDYTSRMSSVEAAVYKEKLSVSAATCFVPRSYHEPVLNCTHVPRDVTQLVSHRIFTELLRQPPNLDWLHSYRLVVSESGQIQTSDGRWWNPGGKFLPLSLSLQTFSYTIVDSHSVLVGARRNSTRIPFYRSQSGAATAEKPIPSKIGQKLGTLAGPTSGRDPIDRNSGPNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACJ9</accession>
    <name>A0A075ACJ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170770.1">
        <property type="nucleotide sequence ID" value="XM_009172506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACJ9"/>
    <dbReference type="GeneID" id="20328365"/>
    <dbReference type="KEGG" id="ovi:T265_14199"/>
    <dbReference type="CTD" id="20328365"/>
    <dbReference type="OrthoDB" id="6260897at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="790" mass="85955" checksum="C3EB8C295734DDF0" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACT5</accession>
    <name>A0A075ACT5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_12554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162542.1">
        <property type="nucleotide sequence ID" value="XM_009164278.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075ACT5"/>
    <dbReference type="GeneID" id="20326722"/>
    <dbReference type="KEGG" id="ovi:T265_12554"/>
    <dbReference type="CTD" id="20326722"/>
    <dbReference type="OrthoDB" id="6252975at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052642">
        <property type="entry name" value="CC-FHA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18853:SF10">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18853">
        <property type="entry name" value="FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="639"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="939"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1381" mass="157885" checksum="60C98B49751779BE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADJ5</accession>
    <name>A0A075ADJ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170141.1">
        <property type="nucleotide sequence ID" value="XM_009171877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADJ5"/>
    <dbReference type="GeneID" id="20320753"/>
    <dbReference type="KEGG" id="ovi:T265_06574"/>
    <dbReference type="CTD" id="20320753"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="23810" checksum="9913A8E65C836BDC" modified="2014-10-01" version="1">MQDAPELHTQLASRSRKTQLSAKRRLHSFDKLVIQELEARQSVQSRQSLVHRLLLVGEKHGRFTSGLYPGRLEGFPRGEIQVTVKNRTTFSRYMTRASFSRMLQTLRLRRLSMCFGVDNTYFQYCLAFGGRPRISLYRSRYPSSTAGAASFRRWWYRVWMAAQLARRICFRRRRRDTIFQDKEEDPLAVTLWGWGCSDLPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGB2</accession>
    <name>A0A075AGB2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167674.1">
        <property type="nucleotide sequence ID" value="XM_009169410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGB2"/>
    <dbReference type="GeneID" id="20318810"/>
    <dbReference type="KEGG" id="ovi:T265_04628"/>
    <dbReference type="CTD" id="20318810"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8678" checksum="AD6D69A0B1484C5B" modified="2014-10-01" version="1">MANRFGKQSWNPRDPSASRLSRAICLENEVSSTHEKNSPQAFASITPEKQFDRNSKYIELGIDQAKFGYNTEAILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGK2</accession>
    <name>A0A075AGK2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596691">
        <property type="protein sequence ID" value="KER28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167424.1">
        <property type="nucleotide sequence ID" value="XM_009169160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGK2"/>
    <dbReference type="STRING" id="6198.A0A075AGK2"/>
    <dbReference type="GeneID" id="20318597"/>
    <dbReference type="KEGG" id="ovi:T265_04415"/>
    <dbReference type="CTD" id="20318597"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14380">
        <property type="entry name" value="UBA2_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="303" mass="32776" checksum="81F0BC4282727186" modified="2014-10-01" version="1">MEDEKTLKQYKVTDKGFIVVMAVSKPSKEPTASAEKAPEAAKPVQSEQSISTNTVTSAQEATVPRSEVPAAAGPESATGESALVTGAEYERAISEIVGMGFDRSMVIRAMRASFNNPDRAVEYLLSGNIPNVVVREQQPAGGRERVDPPGDEHSASESPSSEDPISALASLPQFQQMRALVQANPELLPQLIQQIGADNSELLRLIQENEQGFLEFLNAPISQDAGETEGMESSETTTPGNVRQGEPRQVILTMTQEERAAIERLQALGFPEELVIQAYYACEKNEDAAANFLLSEDPDDEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGP0</accession>
    <name>A0A075AGP0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167378.1">
        <property type="nucleotide sequence ID" value="XM_009169114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGP0"/>
    <dbReference type="STRING" id="6198.A0A075AGP0"/>
    <dbReference type="GeneID" id="20327666"/>
    <dbReference type="KEGG" id="ovi:T265_13499"/>
    <dbReference type="CTD" id="20327666"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12097">
        <property type="entry name" value="DD_RI_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0114">cAMP</keyword>
    <keyword evidence="3" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="279" mass="30701" checksum="E71E32263E160CEB" modified="2014-10-01" version="1" fragment="single">MDDDSFINGVEDYIKRYNIHELLRDSIVNLCLYRPSNPVGYLREYFEKLETKSIPCGADSMENGGVTSSQKSNIPRHLSTTKKPYSTHESGPLPPVSFNQSDNVNHLNCNHKEEPRSHDADFVGANNFLSGTFLNETVPQIPYNVDPNGGASESGVGEAGSSGGNESFTTFSPSGSSEVTRRRSRRGAVSGEVYTEEDAASYVKKVVPKDYKTMTALSKAIAKNVLFSHLDETERSDIFDAMFPVHRNPGDVIIQQGDEGDNFYIVDQGEVDVSTCMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGU0</accession>
    <name>A0A075AGU0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167223.1">
        <property type="nucleotide sequence ID" value="XM_009168959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGU0"/>
    <dbReference type="STRING" id="6198.A0A075AGU0"/>
    <dbReference type="GeneID" id="20327624"/>
    <dbReference type="KEGG" id="ovi:T265_13457"/>
    <dbReference type="CTD" id="20327624"/>
    <dbReference type="OrthoDB" id="10479886at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="630" mass="66981" checksum="C7309CC569807A58" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AII7</accession>
    <name>A0A075AII7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164498.1">
        <property type="nucleotide sequence ID" value="XM_009166234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AII7"/>
    <dbReference type="GeneID" id="20316263"/>
    <dbReference type="KEGG" id="ovi:T265_02075"/>
    <dbReference type="CTD" id="20316263"/>
    <dbReference type="OrthoDB" id="10473634at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="141" mass="15375" checksum="F7D2AB93E4D2F005" modified="2014-10-01" version="1">MLFLYTTFRLVSAAGTVELSFEPPSGKLFVGSEDNIKCLVKNPAPSSEEGKISLSAEPEDPELIYLNQITSQVQPPLGHLTYQKAGQTTVTCTWTGNTEPAVIKTLNVQVLASETTNKGAKIRLVHTEYFIITSFLLSIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIV6</accession>
    <name>A0A075AIV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164044.1">
        <property type="nucleotide sequence ID" value="XM_009165780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIV6"/>
    <dbReference type="GeneID" id="20315902"/>
    <dbReference type="KEGG" id="ovi:T265_01714"/>
    <dbReference type="CTD" id="20315902"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="380" mass="43500" checksum="E2B5D3C88151742A" modified="2014-10-01" version="1">MGRQPFMVLLDTGGWTRWIPSIKSTSAEFAYRNKYTGQPETSISLNQEFETSYSGEKYRGHVVTDELWVGRVFPQFKFVVVMESTGAVDKREGYDGIIGMRRPPSNDGRCEFSNTTILDYIVEAGIVTDAIFTFRFCGEKGVRGDSWFIHGNLEFGGTRTEYYHPPIVSLSLYQGTQWVVDITSIEYGDLLLCERCLAYADTGSPDTYAPAEASNKILETLTVDKHVHGLLHVPAHKLNQVRPLRIKLASRIFTVPSQELTRFVSDYLSVFAFQGLLISYEILFAYMCLFLYFLQVWNVGFYHFAIQIEPDTSEKTWTLGVSLLRHFYLLFDQQNNQMGFAAHYNNYARIGTRPFKRAVMHAEMEPIDPDSTARDVEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJN6</accession>
    <name>A0A075AJN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162646.1">
        <property type="nucleotide sequence ID" value="XM_009164382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJN6"/>
    <dbReference type="GeneID" id="20314766"/>
    <dbReference type="KEGG" id="ovi:T265_00578"/>
    <dbReference type="CTD" id="20314766"/>
    <dbReference type="OrthoDB" id="6278854at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="382" mass="42650" checksum="D68870674ACB74F3" modified="2014-10-01" version="1">MSDYYEGENSCIRCLRSSPIASLLGFIAVLIGGGAFGGATIFARRFLDDMLSAPHLFPCLEYVVYGLMGATGLFAALAYFVCAISSGRNAKQCFESTRKSICGRCCNMLSIICVVFGILLWTAIICLMSYSVISFALLMHRHEGPTRLRLASLDPSILVRGQRSAQDWAQMHRLHQFQPKSLQSSEEERNFFNEPDVDWSDSSIIHGEPPSPSSFQDTQEFTSSIQRDPSQVHRATNDELSKNRAFLTVNNFTGDTNVVLSNQVPQNLPEKVQQQGKQLINQALDLAESARQFFKCDPNKFDLSYYGLYDENGLPIYVAQDTFMSKIPSIMICVSVATGGIFLMILGYLQILLCMAMNYARLQERRYYEASDAGEEGVALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJU6</accession>
    <name>A0A075AJU6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162169.1">
        <property type="nucleotide sequence ID" value="XM_009163905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJU6"/>
    <dbReference type="GeneID" id="20314385"/>
    <dbReference type="KEGG" id="ovi:T265_00197"/>
    <dbReference type="CTD" id="20314385"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14928" checksum="089240BA6ECC8FC5" modified="2014-10-01" version="1">MPAKKKPSRERKSNLKSRRAPGPYALFVSSMRKNYSGSFTQFSKCCAATWRQLSESEKEKFRKKAKKQQKKPGRKHEPKSLAFLRFVSRTYDCLRRKHPEWPSKKIREQLMKNYQKIKCKCVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV05</accession>
    <name>A0A074YV05_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL599286">
        <property type="protein sequence ID" value="KER18601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177652.1">
        <property type="nucleotide sequence ID" value="XM_009179388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV05"/>
    <dbReference type="GeneID" id="20330112"/>
    <dbReference type="KEGG" id="ovi:T265_15947"/>
    <dbReference type="CTD" id="20330112"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="3"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER18601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7806" checksum="1887912CD28E12B3" modified="2014-10-01" version="1" fragment="single">WFQNRRARERKDVSQLEASNSSGTISSKYPLSSALDQIEVSSPSSVQSFSKWPTTNNEPSTALVKLTNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVL4</accession>
    <name>A0A074YVL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597872">
        <property type="protein sequence ID" value="KER18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177442.1">
        <property type="nucleotide sequence ID" value="XM_009179178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVL4"/>
    <dbReference type="GeneID" id="20326313"/>
    <dbReference type="KEGG" id="ovi:T265_12145"/>
    <dbReference type="CTD" id="20326313"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10207" checksum="A27642B99FCEF47E" modified="2014-10-01" version="1">MGLLNGIQFDNGFHGFRVQNTNRKSLIRQCLIGAQFLHGTKRLALFVLRHSAFITFLAVQDAVVRSVGICSINKENKDEDDDNDDGGEDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXD2</accession>
    <name>A0A074YXD2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_15582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KL597247">
        <property type="protein sequence ID" value="KER19313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176938.1">
        <property type="nucleotide sequence ID" value="XM_009178674.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YXD2"/>
    <dbReference type="GeneID" id="20329747"/>
    <dbReference type="KEGG" id="ovi:T265_15582"/>
    <dbReference type="CTD" id="20329747"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="10">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="10">
        <location>
            <begin position="285"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="672"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1694" mass="191714" checksum="45424BA9CA07E216" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ37</accession>
    <name>A0A074YZ37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597116">
        <property type="protein sequence ID" value="KER19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176315.1">
        <property type="nucleotide sequence ID" value="XM_009178051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ37"/>
    <dbReference type="GeneID" id="20325574"/>
    <dbReference type="KEGG" id="ovi:T265_11406"/>
    <dbReference type="CTD" id="20325574"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="183" mass="20533" checksum="DD0F6CD4A928D09B" modified="2014-10-01" version="1">MENIRLTETRALRLPDEPQERRNQSYAVEEFSATLRGSFIDELAGVPNSFVKEFVLSHVNSDTHHFRLHQREALDSSFALTRAHQQRISNGRAGISTLVCDMRVTTTFHQRTLEASELSRLNSDVIGVSDSSNDDPVTVLVEWCLHARLASHVRGSNPGTAIVYALLMSPNESETRVQCFPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZL9</accession>
    <name>A0A074YZL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM81 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597089">
        <property type="protein sequence ID" value="KER20123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176129.1">
        <property type="nucleotide sequence ID" value="XM_009177865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZL9"/>
    <dbReference type="GeneID" id="20325426"/>
    <dbReference type="KEGG" id="ovi:T265_11258"/>
    <dbReference type="CTD" id="20325426"/>
    <dbReference type="OrthoDB" id="10014002at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029619">
        <property type="entry name" value="FAM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420:SF4">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="393" mass="46312" checksum="8748C56F0C241BA6" modified="2014-10-01" version="1">MTFRSYFAPYATDLPLSEYKLPRLSPTYRNIVAYPHTHRRIPSPPNERDRQGLLEWRVGVQESLTVGLVEKMSFLKEEMLEQLKFSKKLENQQENHKDFLRNELQALAQSISKMKEEVHDFEENVRDKWQTVNSAAITLRNLENHHTTSLADVRSRITRSDQAINLLSQKIAQLGEELRAMNESHRRDIQEVHGMMKANEQKSGDLNIEVDRTFQRLTQTIQRTQEDLQKQILDLERRLLQQIADTQREIHAYVSNSLGERNQLESRVMESLNEMFNEVEQRVSLAEQRAEEARVDEELEARVNDYEKEMTTFRQQVLNTFKEVEMRMNRLSDELYENHRGLVDAVREEMRQGFCTTHDTISNMKSVLESKIRISEENLQLELGQLRKLVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZU3</accession>
    <name>A0A074YZU3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597069">
        <property type="protein sequence ID" value="KER20311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175954.1">
        <property type="nucleotide sequence ID" value="XM_009177690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZU3"/>
    <dbReference type="STRING" id="6198.A0A074YZU3"/>
    <dbReference type="GeneID" id="20329512"/>
    <dbReference type="KEGG" id="ovi:T265_15347"/>
    <dbReference type="CTD" id="20329512"/>
    <dbReference type="OrthoDB" id="6264479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="26874" checksum="3A6930D9F6932799" modified="2014-10-01" version="1" fragment="single">IDGYPVGGLTISLLGINNPRLGLPVAADGHLGLGYPESSRTVPDFNILNVMSANQMIDYKRFTLFCVCAPHRNDLEPDARIVFGSHDTIDLRSFRMVPAEVTRASWKVPVTSLKTTTARISSRSFFATLDTTTWLNKASADRAGLINTALGTTLSGNLYVVDCDRIPGLPTLVVSLQGADLRFPPENYIQKEEVNGQTRCFSSIVPDPQITTERMVFGMTFLEHFTTLFDQQEKQIGFKPRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZV9</accession>
    <name>A0A074YZV9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598168">
        <property type="protein sequence ID" value="KER18747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177506.1">
        <property type="nucleotide sequence ID" value="XM_009179242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZV9"/>
    <dbReference type="GeneID" id="20330015"/>
    <dbReference type="KEGG" id="ovi:T265_15850"/>
    <dbReference type="CTD" id="20330015"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7969" checksum="9C6892F686B3C885" modified="2014-10-01" version="1" fragment="single">QKRNSRLFWNQSEGLAELIKCNLSGIVSVKYAEKCLKCQKNNKFDLRGGNVGHCDGRSDRRLDIQSDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZW4</accession>
    <name>A0A074YZW4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598141">
        <property type="protein sequence ID" value="KER18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177501.1">
        <property type="nucleotide sequence ID" value="XM_009179237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZW4"/>
    <dbReference type="GeneID" id="20326339"/>
    <dbReference type="KEGG" id="ovi:T265_12171"/>
    <dbReference type="CTD" id="20326339"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22154" checksum="CECBF5C706B6F0D0" modified="2014-10-01" version="1">MVWDEFSYSVEQMKNKAVTTVFAKSNTKNLLPGEEALSVDEKAVRFLIDESSDDVGLLAPESSEASLIMGIPKFVAMEMSLSKSSRSRQPDLYNLSDKGRHNQYLNTVFLAFSSKSNSAIESTALQAEYNGKEPKYDEQVPYKAEDAVKEEESASEDNEDGDEVDKCIGSEERIEDACGEELLVGDWREKIIPPLHAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0J8</accession>
    <name>A0A074Z0J8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597042">
        <property type="protein sequence ID" value="KER20566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175692.1">
        <property type="nucleotide sequence ID" value="XM_009177428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0J8"/>
    <dbReference type="GeneID" id="20325082"/>
    <dbReference type="KEGG" id="ovi:T265_10914"/>
    <dbReference type="CTD" id="20325082"/>
    <dbReference type="OrthoDB" id="6272649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF130">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="742" mass="81759" checksum="CD573E711EB69CD9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1Y1</accession>
    <name>A0A074Z1Y1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597193">
        <property type="protein sequence ID" value="KER19502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176754.1">
        <property type="nucleotide sequence ID" value="XM_009178490.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_11745"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1017" mass="104712" checksum="AC3FDBF6AFD57695" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7F9</accession>
    <name>A0A074Z7F9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596867">
        <property type="protein sequence ID" value="KER23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173202.1">
        <property type="nucleotide sequence ID" value="XM_009174938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7F9"/>
    <dbReference type="STRING" id="6198.A0A074Z7F9"/>
    <dbReference type="GeneID" id="20323167"/>
    <dbReference type="KEGG" id="ovi:T265_08988"/>
    <dbReference type="CTD" id="20323167"/>
    <dbReference type="OrthoDB" id="6222374at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="21731" checksum="ED3333CF2337598C" modified="2014-10-01" version="1">MEANLHGIELMIDVFMRLDKANPDGVNKEELIRECEAQKLDAEQVTKWLERFGMKTIRMDEFCSQFGFNLKEMILEEVERANARSGEAPKLSEDIELISTTMSMTKQVEITEKFKTLVNESGEDEAKAGLIPKKMKEYLDETFEHGWQVVMVEGKYWMHFSHEPFTSLQFRYNDYICLVWRTPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Z8</accession>
    <name>A0A074Z7Z8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596860">
        <property type="protein sequence ID" value="KER23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173047.1">
        <property type="nucleotide sequence ID" value="XM_009174783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Z8"/>
    <dbReference type="GeneID" id="20323045"/>
    <dbReference type="KEGG" id="ovi:T265_08866"/>
    <dbReference type="CTD" id="20323045"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12729" checksum="5E2196FB71F0F7CB" modified="2014-10-01" version="1">MLSVAFFRSTRWLTGCSTNSLAVTSVVQTRPLLLDFPCLGLGNLVVPQTSCFLLVAWQLSAKKWTQKSKRKPLNRLLEQLSNGAILTATGSRYLVLLGAGTPVCDMTLPTTYKHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8D5</accession>
    <name>A0A074Z8D5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="KL596938">
        <property type="protein sequence ID" value="KER21827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174435.1">
        <property type="nucleotide sequence ID" value="XM_009176171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8D5"/>
    <dbReference type="STRING" id="6198.A0A074Z8D5"/>
    <dbReference type="GeneID" id="20324111"/>
    <dbReference type="KEGG" id="ovi:T265_09943"/>
    <dbReference type="CTD" id="20324111"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="362" mass="39689" checksum="EB4B72C2538262C2" modified="2014-10-01" version="1">MAPVSDVAKRPVPESELRTWGDCLLDPCAKLVDRARALWGLRHANELLAVDLIAKFLCETVEPSPAANALLQHEAAYCLGQRRNPEAVPYLIQAVHDSRHPSVVRHEAAEALAALCELPGVDLDSVEQVLSKFAASDVVELAETCQLGLGRLNWLRQRSGCPPKRQIAKEVFPDTVDPAPSIDPDFREDATVLRDIMMDPGKSLFTRYQALFSLRDCILEAKFEPSDRLCSADALATMLAEGLHAPGSALLRHEVAFVLGQLCMPVTVPDLAESLQLTSEHPMVRHEAAEALGAVLGHINVDSTDDNHPNMHEPFALAARCVLQEYLHDEEPLVRESCVLALDIADYVCSKDRFQYAAVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9S3</accession>
    <name>A0A074Z9S3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596906">
        <property type="protein sequence ID" value="KER22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173939.1">
        <property type="nucleotide sequence ID" value="XM_009175675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9S3"/>
    <dbReference type="GeneID" id="20323735"/>
    <dbReference type="KEGG" id="ovi:T265_09566"/>
    <dbReference type="CTD" id="20323735"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19944" checksum="CA34B21DA84193AE" modified="2014-10-01" version="1">MGDGEIHLENKKSNLSGCIFRNWNTQHSSTVSETVKAKFTGKVEEQWTVEKNVQKTAVEMIWEKKPARKDRFDENTTVISSTSDRKGGACNTVLKNPSNSLDQKRYFKTQQPMKLEITNESWTKLGEEFQSYTDRRLHKAPWSTKSRMSLNRISMSSFKIFGLAESLRNVKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA59</accession>
    <name>A0A074ZA59_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173778.1">
        <property type="nucleotide sequence ID" value="XM_009175514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA59"/>
    <dbReference type="GeneID" id="20323616"/>
    <dbReference type="KEGG" id="ovi:T265_09447"/>
    <dbReference type="CTD" id="20323616"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703897" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8863" checksum="5A6E215D5D295696" modified="2014-10-01" version="1">MIQPLFFTILSLAVRSYAQIEGISCLQQISGQPPTIWENCEYCLGMLPLLEMIWNPCVPRSRGIQQKQVAVSVHFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA83</accession>
    <name>A0A074ZA83_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596895">
        <property type="protein sequence ID" value="KER22502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173741.1">
        <property type="nucleotide sequence ID" value="XM_009175477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA83"/>
    <dbReference type="GeneID" id="20323592"/>
    <dbReference type="KEGG" id="ovi:T265_09423"/>
    <dbReference type="CTD" id="20323592"/>
    <dbReference type="OrthoDB" id="10333598at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="271" mass="30790" checksum="1ED2EC70A2E4BC7D" modified="2014-10-01" version="1">MLGYRIKRSKKKRKRSAVAPFRCLAATPFEGSLRARILPGCPSLDRRSRVAEVGFKPRTDSVPTLIHHSHVTHSHKVFTETMNSVLAVFTFLSNDLNYESDAFTASVTSVKNTQTAIVGQFDKLEELCKNCLNHETSNEFNIKELVTTDRLDSDQVFVASSGSFSFYLWLIRGTPAAAWPVLEFGKLQAYKLAADVFQMKQPTGCALNDDDKEADAMINKLKDLVNNMKKFNMELPSTRYSIKKNSKWYPEILVIFLNIYTTVSKNIQYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAE8</accession>
    <name>A0A074ZAE8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172001.1">
        <property type="nucleotide sequence ID" value="XM_009173737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAE8"/>
    <dbReference type="GeneID" id="20322222"/>
    <dbReference type="KEGG" id="ovi:T265_08043"/>
    <dbReference type="CTD" id="20322222"/>
    <dbReference type="OrthoDB" id="6219502at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19843" checksum="A016D06692F289B2" modified="2014-10-01" version="1">MAEETFLNAFIQIDTNNDGIITLADLEEYAKHGTVSADFVPRWRKLFDPNNTGQITYEHFCATLGISKKKRMEVAVKKSQVVFYQTNMSETMKNEALLIIKQQYCVQNPDSSMPPTLVQLDETLGPRWYGRAILDSSDEHFPGSYLSYSCDGGANKYVVYKIVEEKKKKGCCPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAX6</accession>
    <name>A0A074ZAX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596885">
        <property type="protein sequence ID" value="KER22682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173563.1">
        <property type="nucleotide sequence ID" value="XM_009175299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAX6"/>
    <dbReference type="STRING" id="6198.A0A074ZAX6"/>
    <dbReference type="GeneID" id="20328966"/>
    <dbReference type="KEGG" id="ovi:T265_14800"/>
    <dbReference type="CTD" id="20328966"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="495" mass="56205" checksum="CE6F44805105D1B9" modified="2014-10-01" version="1">MVAENYSTSHDRFRRSWGSLGKCSPRVSVNLMSYLNPNWTVCAYLMNPNWKGETEAGLSKSFHLSKVLHKVVESSSTVHDRFRPSWGLSDRRSPRPIPTGHSKTGAFVHDTAGLFFQLDCAVGSRWFKWLEREFTDREVRGTNPSSASRHPLSRLGQPGGIPALVLPSGCMAARPLRDFWTGKQNSHLHLIHKTGHTSSPERVFLNCAGYSLTPIIHCSNPSKRYKVTPQIPQEIFVFKRRKTSLQEQNMLLACLPISSSSTATHLHPLKVVRLPSISIYLCQKRELSHFIKETTHKVAENSSTAHNRFRPSSSGSTGRRSPRVSVNLVFYLNPNWTVCEKYTHLQINLVSTRDSTESLFYDILQLNLLHIDRLMIYTIFEISQCIFIKETTHKVGSIGTQGRRKLGDCTYLLSPKKGETGRGLSRSFQQLSKSTSERSSLGTIHVCYEQNTYPDKTPKPQRKVAQRVLSVCYWEVLTSGSIDRHNQDSYWVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB41</accession>
    <name>A0A074ZB41_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171727.1">
        <property type="nucleotide sequence ID" value="XM_009173463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB41"/>
    <dbReference type="STRING" id="6198.A0A074ZB41"/>
    <dbReference type="GeneID" id="20322009"/>
    <dbReference type="KEGG" id="ovi:T265_07830"/>
    <dbReference type="CTD" id="20322009"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1217" mass="137697" checksum="65F40CEB351E166D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD50</accession>
    <name>A0A074ZD50_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Casein kinase II subunit beta</fullName>
            <shortName evidence="5">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171102.1">
        <property type="nucleotide sequence ID" value="XM_009172838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD50"/>
    <dbReference type="STRING" id="6198.A0A074ZD50"/>
    <dbReference type="GeneID" id="20321518"/>
    <dbReference type="KEGG" id="ovi:T265_07339"/>
    <dbReference type="CTD" id="20321518"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="216" mass="24783" checksum="456E5B18EE582F8F" modified="2014-10-01" version="1">MSSSEEISWISWFCGLRGNEFFCEVEEDYIQDRFNLTGLSEQVPEYREALDMILDLETDPSDNQDNTDLVEQAAEMLYGLIHARYILTNRGICVMVAKWQQGDFGCCPRVYCESQPCLPIGLSDVPGEAMVKIYCPRCQDVYSPKSTRHHYTDGAYFGTGFPHMLFLVHPEYRPKRAQKQFTARLFGFKIHPLAYQLQYQAASGMSGPMRGFPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD53</accession>
    <name>A0A074ZD53_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-tyrosine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596992">
        <property type="protein sequence ID" value="KER21125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175131.1">
        <property type="nucleotide sequence ID" value="XM_009176867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD53"/>
    <dbReference type="STRING" id="6198.A0A074ZD53"/>
    <dbReference type="GeneID" id="20324652"/>
    <dbReference type="KEGG" id="ovi:T265_10484"/>
    <dbReference type="CTD" id="20324652"/>
    <dbReference type="OrthoDB" id="6228606at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59531" checksum="0FE22F7311C2591E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD71</accession>
    <name>A0A074ZD71_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171138.1">
        <property type="nucleotide sequence ID" value="XM_009172874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD71"/>
    <dbReference type="GeneID" id="20328435"/>
    <dbReference type="KEGG" id="ovi:T265_14269"/>
    <dbReference type="CTD" id="20328435"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18057" checksum="0817E1172900EA43" modified="2014-10-01" version="1" fragment="single">VQSAPGEHLWIDTNASGDLCYVPEPECCKPTTEEKRNNSQCSLRRYSTVKTHIRSRVSDILDLESQRQECTLNACTTHKSVVITQTAHNGKQTQVTDFDPKEFQSSNSLGGLRKADPSLDCCLHVTLTILHSKTTFDHTLDPVEKRSALCVALLVTSNAWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDQ4</accession>
    <name>A0A074ZDQ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596837">
        <property type="protein sequence ID" value="KER23752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172505.1">
        <property type="nucleotide sequence ID" value="XM_009174241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDQ4"/>
    <dbReference type="GeneID" id="20322619"/>
    <dbReference type="KEGG" id="ovi:T265_08440"/>
    <dbReference type="CTD" id="20322619"/>
    <dbReference type="OrthoDB" id="2016588at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704099" description="Cystatin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14103" checksum="981581A2F1DFCF31" modified="2014-10-01" version="1">MLSNCFIFLALSFISPSSETLVGGYTEFHLPNADEIQTFKTLLNLQIPTFLGLTASDVDDAEILGISSQVVSGINYRINWVTQPRTDDVTSIGDETFPVQLQISVNRSATNQCTRATYIPRHCWIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE13</accession>
    <name>A0A074ZE13_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170860.1">
        <property type="nucleotide sequence ID" value="XM_009172596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE13"/>
    <dbReference type="STRING" id="6198.A0A074ZE13"/>
    <dbReference type="GeneID" id="20321331"/>
    <dbReference type="KEGG" id="ovi:T265_07152"/>
    <dbReference type="CTD" id="20321331"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="616" mass="69109" checksum="72CA51C7948A577F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE16</accession>
    <name>A0A074ZE16_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170726.1">
        <property type="nucleotide sequence ID" value="XM_009172462.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZE16"/>
    <dbReference type="GeneID" id="20321217"/>
    <dbReference type="KEGG" id="ovi:T265_07038"/>
    <dbReference type="CTD" id="20321217"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="230"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="326"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="797"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1615" mass="179867" checksum="7D6110247DC361FE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZED7</accession>
    <name>A0A074ZED7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596826">
        <property type="protein sequence ID" value="KER24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172242.1">
        <property type="nucleotide sequence ID" value="XM_009173978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZED7"/>
    <dbReference type="STRING" id="6198.A0A074ZED7"/>
    <dbReference type="GeneID" id="20328679"/>
    <dbReference type="KEGG" id="ovi:T265_14513"/>
    <dbReference type="CTD" id="20328679"/>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="22894" checksum="1D18244A285A7FEB" modified="2014-10-01" version="1" fragment="single">MLQSDSTNCVIDLTSQETCSGFTRKHTTPMPTSTPELRKRLPTFPYERRLSKIDTLRLAIAYLALLNDMLTNMDCSTNDQSGCGVFSFILNRLRSPTRRFLSWYTSDGSSGRKVRVSNPTSVSRLPLSRLGQPGSIPALMQPSGGTTVRHRMGATAVLHQHFSNLIARLDWVQWDRLGFRGQVDWTSLKTSCNNGLLWTQREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEK2</accession>
    <name>A0A074ZEK2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170648.1">
        <property type="nucleotide sequence ID" value="XM_009172384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEK2"/>
    <dbReference type="GeneID" id="20328342"/>
    <dbReference type="KEGG" id="ovi:T265_14176"/>
    <dbReference type="CTD" id="20328342"/>
    <dbReference type="OrthoDB" id="543859at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="357" mass="40178" checksum="00AC08A14F2DD511" modified="2014-10-01" version="1" fragment="single">AVQQILDEESITTDTWSTSRNGQFFKVSNYSSNSFWRVDNRIMYFIVGTWTTLFDFLLAVEFSVVGEDKIESILDRLAFFNVGKTVDSSIMVIEPTAFLRKRERPPKTGHVSQVGIQEFLRSLKSRLCVAQVYNEIKQRGRFDMNYLCNLICAAVVADIALVTNSAGVVFASMLLSPLMVFRHRRPSTIHFELYYRSAVAPFRCLTAMPPEGCTRAGILPGCQSLDRGSREAALGFELRTYGPSDPIMCILFGLTLREPHMLRTGARNTAISLLFCVLLVGKCELKQSDRNYIYRSFLHLLGNLDHSYSLAGEPLAIQSSGRFDNNQHDQLSFHCLSRNLIPSLSDIQKANCSVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEU1</accession>
    <name>A0A074ZEU1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170554.1">
        <property type="nucleotide sequence ID" value="XM_009172290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEU1"/>
    <dbReference type="GeneID" id="20328323"/>
    <dbReference type="KEGG" id="ovi:T265_14157"/>
    <dbReference type="CTD" id="20328323"/>
    <dbReference type="OrthoDB" id="6226268at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="528" mass="60355" checksum="438AE824DC9976F5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFG2</accession>
    <name>A0A074ZFG2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_14110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170344.1">
        <property type="nucleotide sequence ID" value="XM_009172080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFG2"/>
    <dbReference type="STRING" id="6198.A0A074ZFG2"/>
    <dbReference type="GeneID" id="20328276"/>
    <dbReference type="KEGG" id="ovi:T265_14110"/>
    <dbReference type="CTD" id="20328276"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER25928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="817" mass="91142" checksum="E2AE8D6C98E6536F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFW8</accession>
    <name>A0A074ZFW8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170140.1">
        <property type="nucleotide sequence ID" value="XM_009171876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFW8"/>
    <dbReference type="GeneID" id="20320752"/>
    <dbReference type="KEGG" id="ovi:T265_06573"/>
    <dbReference type="CTD" id="20320752"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19005" checksum="27812BB05FE5DC8F" modified="2014-10-01" version="1">MLPEQSGAAALLATSLQAELSETEVTSQEFYAVAPGQIDNDEYAPPSRRLKTQLWCPDIIGDSVEAHSLGATLFSKHVQNEQIPIGSIILLGNPFVNNCRSAPSGPRTGDESNEFSVNAKLRSSTNLSLPNPPTTVFCLPWISAFSGSVNVKRATKSHYSAQDRPTAATKKSYGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGJ8</accession>
    <name>A0A074ZGJ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596902">
        <property type="protein sequence ID" value="KER22375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173874.1">
        <property type="nucleotide sequence ID" value="XM_009175610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGJ8"/>
    <dbReference type="GeneID" id="20323685"/>
    <dbReference type="KEGG" id="ovi:T265_09516"/>
    <dbReference type="CTD" id="20323685"/>
    <dbReference type="OrthoDB" id="428850at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="100411" checksum="EB2B7C5A40248ED1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGK5</accession>
    <name>A0A074ZGK5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596797">
        <property type="protein sequence ID" value="KER24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171449.1">
        <property type="nucleotide sequence ID" value="XM_009173185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGK5"/>
    <dbReference type="STRING" id="6198.A0A074ZGK5"/>
    <dbReference type="GeneID" id="20321796"/>
    <dbReference type="KEGG" id="ovi:T265_07617"/>
    <dbReference type="CTD" id="20321796"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="117"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="381"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="106614" checksum="F9A739920C946A7A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH65</accession>
    <name>A0A074ZH65_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171210.1">
        <property type="nucleotide sequence ID" value="XM_009172946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH65"/>
    <dbReference type="STRING" id="6198.A0A074ZH65"/>
    <dbReference type="GeneID" id="20321607"/>
    <dbReference type="KEGG" id="ovi:T265_07428"/>
    <dbReference type="CTD" id="20321607"/>
    <dbReference type="OrthoDB" id="6258141at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="248" mass="28455" checksum="EE563D6D1DD1D77D" modified="2014-10-01" version="1">MQFLFIPKRTKTVVFFIALRRLLCVLERRNLEKLQQRLLRCQTDSQELLKRRAAVLNFLNSLGRRRLKSLKDLETHNERIERVRASYLRELLHSHLVVDLSPDVGSPDTFSGSGLHLDRENIFIGPEPLLSSHTVLTYCIPAIRAAALFTDLWIPASIQQHLQLDGSFLTGLPQRDDLGRVYSAVLHAVHMLCSCRLVDVRSVLERAGRTLPPNHSVFNPLLGLFCLARFTQPRQVLPLQSPWYNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH94</accession>
    <name>A0A074ZH94_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171178.1">
        <property type="nucleotide sequence ID" value="XM_009172914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH94"/>
    <dbReference type="GeneID" id="20321583"/>
    <dbReference type="KEGG" id="ovi:T265_07404"/>
    <dbReference type="CTD" id="20321583"/>
    <dbReference type="OrthoDB" id="10439624at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="316" mass="34962" checksum="A774E1353E8A2C07" modified="2014-10-01" version="1">MSSDAFGGFRRQRSMKEITKRLGTVGSTRLPGWGPRDPHCAWLETLQDMAANRCQWRSCCQFLSRLPELSNKSWLYGSEASVLNTDVMPSMMELDGNFSAFIECQSIASHGFSKCSGTAQTNYTDSAAQTCNGSAKLITDSPWLMPNQQALPDWDRNERQIGGDPGQAGEYALDKRGHIRERIWPALRYLRLGSFEWTCLRVLALLQSVHFVVFDLNELRARWLSGYSANLLTGRSVVRTRLPHHFFLGSSNLAEAELNCHIMTTAVTSAAEFAGNGLHTSLPSHCLTASGSLPSFKEIGRLAYAARGQASATYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHW9</accession>
    <name>A0A074ZHW9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169361.1">
        <property type="nucleotide sequence ID" value="XM_009171097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHW9"/>
    <dbReference type="GeneID" id="20320132"/>
    <dbReference type="KEGG" id="ovi:T265_05950"/>
    <dbReference type="CTD" id="20320132"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13325" checksum="824C6DC953194AB9" modified="2014-10-01" version="1">MPEQEHDRSTESDVTMNKNLGLSIPQRVSALTTKTTSAKRVIGTLICTFAKRATRLSPLDSFVAILLQEGGVILLVPQHNFSSFHDGGGVTWCTKVKDTKGSVFVKLNKQVCQLEFPNSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJD1</accession>
    <name>A0A074ZJD1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169169.1">
        <property type="nucleotide sequence ID" value="XM_009170905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJD1"/>
    <dbReference type="STRING" id="6198.A0A074ZJD1"/>
    <dbReference type="GeneID" id="20328029"/>
    <dbReference type="KEGG" id="ovi:T265_13862"/>
    <dbReference type="CTD" id="20328029"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF352">
        <property type="entry name" value="BCDNA.GH04802-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel" evidence="8">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28218" checksum="32BAA21B45F5E69A" modified="2014-10-01" version="1" fragment="single">LRAPRLYDLVNTGLLKGHGIKEVITCDPKNDKKTIFFRLKYAHVSTGSLEILLSISVLFSHTGYGYTTPKTAQGKILTIFYALIGIPLVVLYLSNIGDYLADVFRALYSRTCRNTCENYCSISLFTSVVRSLVRRYYGKPVEDEIPNDEMIHIDGVAGGGNVPFRRRKRVLLKAFSLTDDECPHDESDLEANELSFSGVRKDPNHIQPTEETGRTPKTRCGPNIERLRTLFEEIGVYRVMHSPRLVSAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJV7</accession>
    <name>A0A074ZJV7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168953.1">
        <property type="nucleotide sequence ID" value="XM_009170689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJV7"/>
    <dbReference type="GeneID" id="20319812"/>
    <dbReference type="KEGG" id="ovi:T265_05630"/>
    <dbReference type="CTD" id="20319812"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="31238" checksum="280806E765F4E4FC" modified="2014-10-01" version="1">MHPGQQFYQDPYSPGQYGMPQQAYPGQVQIPPQFYPQQPAYSQQLYWQQPHSSPSYPQGYEQQQQHGSYRNIFALRPKQTADSFSSAGFDDVEIRNAFIRKVYLILFAQLTITAGVVALFMYINFQVCSKESHSIPCIPTLVMAYFAGVISCNYGTLSVLSAVGVTAVTCLIVTVFAMTTCIDFTKCYLVIAVLSVVLILFGIACLVVYYVLGYSKLLHTIYGGVTACFFVLYIILDTQMLIGGRSAEISPEEYIFAAVQLYVDIINLFLIILSLTGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJX6</accession>
    <name>A0A074ZJX6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_06607</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170175.1">
        <property type="nucleotide sequence ID" value="XM_009171911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJX6"/>
    <dbReference type="STRING" id="6198.A0A074ZJX6"/>
    <dbReference type="GeneID" id="20320786"/>
    <dbReference type="KEGG" id="ovi:T265_06607"/>
    <dbReference type="CTD" id="20320786"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF140">
        <property type="entry name" value="LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="689"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="778"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER26077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119341" checksum="1214860414E17E5C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKL1</accession>
    <name>A0A074ZKL1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168384.1">
        <property type="nucleotide sequence ID" value="XM_009170120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKL1"/>
    <dbReference type="GeneID" id="20327867"/>
    <dbReference type="KEGG" id="ovi:T265_13700"/>
    <dbReference type="CTD" id="20327867"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8613" checksum="CBAD2D87208125D3" modified="2014-10-01" version="1" fragment="single">NPGESLFCDVTRQLNVLHKAASCFNCYDIRNTRYMQLNVLHQAASCFSRYDIRDIVIHVHICNALLIGLLISRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLC9</accession>
    <name>A0A074ZLC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168366.1">
        <property type="nucleotide sequence ID" value="XM_009170102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLC9"/>
    <dbReference type="GeneID" id="20319352"/>
    <dbReference type="KEGG" id="ovi:T265_05170"/>
    <dbReference type="CTD" id="20319352"/>
    <dbReference type="OrthoDB" id="112749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204:SF2">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="22463" checksum="104AA7B116973813" modified="2014-10-01" version="1">MFEEGSYHNQRIIAIEFVRQELVGAAGFWEQWTVPQKAYKLNHILSRLRRRGFLDLLQLRNTTGSVDRVPVPRHRLIEACQELNKQLFSCFSPPSKLTVCGRALDKHTIRDSSGWWGQVSGTEEKKNEDGLNKVNQILDDAMWINIHELPGSIPTLEVRTAQGHGVRFDYEPLRFRGFVEPHQTEGWLNRYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLQ0</accession>
    <name>A0A074ZLQ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KL596816">
        <property type="protein sequence ID" value="KER24290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171986.1">
        <property type="nucleotide sequence ID" value="XM_009173722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLQ0"/>
    <dbReference type="STRING" id="6198.A0A074ZLQ0"/>
    <dbReference type="GeneID" id="20328625"/>
    <dbReference type="KEGG" id="ovi:T265_14459"/>
    <dbReference type="CTD" id="20328625"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF13">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="378"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="684" mass="76989" checksum="F4AFB55C6C4567D1" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLQ7</accession>
    <name>A0A074ZLQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167936.1">
        <property type="nucleotide sequence ID" value="XM_009169672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLQ7"/>
    <dbReference type="GeneID" id="20319008"/>
    <dbReference type="KEGG" id="ovi:T265_04826"/>
    <dbReference type="CTD" id="20319008"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9627" checksum="A31E2B3DE9ABBC22" modified="2014-10-01" version="1">MFMVDPSPVHRFKWYCRNEGSSVDPDCTKFTDDTHLHINLVLTGDSLEPLVYYDVLQLSLLHTRSSVIQLAQYLRYSSIFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU9</accession>
    <name>A0A074ZLU9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169531.1">
        <property type="nucleotide sequence ID" value="XM_009171267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU9"/>
    <dbReference type="GeneID" id="20320271"/>
    <dbReference type="KEGG" id="ovi:T265_06089"/>
    <dbReference type="CTD" id="20320271"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11029" checksum="C8B7497481D0704B" modified="2014-10-01" version="1">MTNRRTASSRAADNRFGRATNDERDRGNRWSTQNMSSLLNSSHTASRLQISLSDIMIASGSSGCVPSSLRKFYHKTLEAGQLQELVPCILVNHADEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMF1</accession>
    <name>A0A074ZMF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167659.1">
        <property type="nucleotide sequence ID" value="XM_009169395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMF1"/>
    <dbReference type="GeneID" id="20318795"/>
    <dbReference type="KEGG" id="ovi:T265_04613"/>
    <dbReference type="CTD" id="20318795"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6849" checksum="EDE34CC2B7D16A10" modified="2014-10-01" version="1">MLDRMRVAWWFVEETSVPVPSSSRLMKSTSGQQFGGHNEETIYPSIYTSSGIHTLSTPSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNA5</accession>
    <name>A0A074ZNA5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167337.1">
        <property type="nucleotide sequence ID" value="XM_009169073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNA5"/>
    <dbReference type="GeneID" id="20318534"/>
    <dbReference type="KEGG" id="ovi:T265_04352"/>
    <dbReference type="CTD" id="20318534"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13707" checksum="4DFB67788E89A35B" modified="2014-10-01" version="1">MLISPRLVLETHAVPAAMSYSYSWEVKEYMDQTNEKNPSDEYFKSDIVDKDPFECHFSEDVVPFRGGGLGDRHSDRLSKTRKERLRISSVPEAPTKIARALFLSAIRDRANPKTHLVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPU1</accession>
    <name>A0A074ZPU1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168399.1">
        <property type="nucleotide sequence ID" value="XM_009170135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPU1"/>
    <dbReference type="STRING" id="6198.A0A074ZPU1"/>
    <dbReference type="GeneID" id="20319373"/>
    <dbReference type="KEGG" id="ovi:T265_05191"/>
    <dbReference type="CTD" id="20319373"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="202"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="620" mass="70954" checksum="3DDCFF7F302176AA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR84</accession>
    <name>A0A074ZR84_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="3">2.4.1.132</ecNumber>
            <ecNumber evidence="3">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="3"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3"/>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167890.1">
        <property type="nucleotide sequence ID" value="XM_009169626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR84"/>
    <dbReference type="STRING" id="6198.A0A074ZR84"/>
    <dbReference type="GeneID" id="20318970"/>
    <dbReference type="KEGG" id="ovi:T265_04788"/>
    <dbReference type="CTD" id="20318970"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="308" mass="34277" checksum="886F973B4A68699F" modified="2014-10-01" version="1">MLLFKTTDIAKCYLKCMRKSSTRFSDNVNSSVHLPAGVVRQTFPSLAKSELEVLYPVANTDSLRLPSAVVDFDDPNGLSNCRQSCRNALPGHIIPKSARFVFVSINRYERKKNLSLALFALSHLFIHWDELVDSDKSGHAKPSDVHLVLAGGYDTRVAENVEYHKELTALADELKIGDHVTFVRSCPSEVKTLLISSSDAVLYTPDREHFGIVPVEAMFLYRPVIALDSGGPRETVLDGSTGFLCRAEPEARLPGCFAVQLARFLNDPSLVSRMGKMAHRRVVEHFSCNAFRKQLCDIISHLSAPNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH3</accession>
    <name>A0A074ZRH3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170304.1">
        <property type="nucleotide sequence ID" value="XM_009172040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH3"/>
    <dbReference type="GeneID" id="20320885"/>
    <dbReference type="KEGG" id="ovi:T265_06706"/>
    <dbReference type="CTD" id="20320885"/>
    <dbReference type="OrthoDB" id="10380358at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9355" checksum="A08C9DDE322501E8" modified="2014-10-01" version="1">MATGAIDNGSVTHRDAVRLITRLDWSSRLIDAIMEEQHAGPRNVDVSFQASDIITEVGEYFLIEQNLLTLFDQWQAVHLISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS05</accession>
    <name>A0A074ZS05_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166396.1">
        <property type="nucleotide sequence ID" value="XM_009168132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS05"/>
    <dbReference type="GeneID" id="20327458"/>
    <dbReference type="KEGG" id="ovi:T265_13291"/>
    <dbReference type="CTD" id="20327458"/>
    <dbReference type="OrthoDB" id="10479649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6996" checksum="8EA70BCA99EB9BF7" modified="2014-10-01" version="1" fragment="single">VPHQVASCFSCYDIRDIAIHVSSQCTTHKVAENPSTAHDRFRPSSGSSGRRSLRASVNLMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTH8</accession>
    <name>A0A074ZTH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165510.1">
        <property type="nucleotide sequence ID" value="XM_009167246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTH8"/>
    <dbReference type="GeneID" id="20317081"/>
    <dbReference type="KEGG" id="ovi:T265_02893"/>
    <dbReference type="CTD" id="20317081"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7737" checksum="1EBB4778CCDD7465" modified="2014-10-01" version="1" fragment="single">CPMAMEAMRRSLQVSSRLDCQKERTISAPKYHVTIRKHERLDTARLSKPTQGKSIGRDRVRTTGLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTL0</accession>
    <name>A0A074ZTL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165798.1">
        <property type="nucleotide sequence ID" value="XM_009167534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTL0"/>
    <dbReference type="STRING" id="6198.A0A074ZTL0"/>
    <dbReference type="GeneID" id="20327332"/>
    <dbReference type="KEGG" id="ovi:T265_13164"/>
    <dbReference type="CTD" id="20327332"/>
    <dbReference type="OrthoDB" id="6022136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="192" mass="21310" checksum="27D2630633D49BD7" modified="2014-10-01" version="1" fragment="single">VLQFFVEVVSHTCSPGRGEILVRSQGSQSDGESSKSGQFFSPNWPKTFEPGRRCVYRFIAASGEKVHLRFQHFQLGGKMPLCTEDFLDVYIDVASSTLDTDRENAVLSHMASGEPPTTTPFSAAVYSSVLDRSALLGRYCGNYLADSRLQFVSLHREIVLDFYANLEGLSKQWAYSGYSALGFEGTYEFVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTR4</accession>
    <name>A0A074ZTR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167041.1">
        <property type="nucleotide sequence ID" value="XM_009168777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTR4"/>
    <dbReference type="STRING" id="6198.A0A074ZTR4"/>
    <dbReference type="GeneID" id="20318305"/>
    <dbReference type="KEGG" id="ovi:T265_04119"/>
    <dbReference type="CTD" id="20318305"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="36486" checksum="0F924CDCCD12CDFC" modified="2014-10-01" version="1">MPVKNLHWSEKKRILVTGGAGFVGSHLVDRLMQDGHEVLALDNFATGRRHNIEHWLGHSNFELIHHDVSEPIHIQVDEIYHLASPASPPHYMLNPIRTIKANTLGTLNMLGLARRTNARFLFSSTSEVYGDPAVHPQPESYWGNVNPIGPRACYDESKRLGETLTYAYSNRLGLSVKIARIFNTYGPRMQLDDGRVVSNFILQSLTNKPLTVYGSGNQTRSFQYVSDLVDGLVRLMASNYSLPVNLGNPEELSVLELADIIRKFTGSNSSIEFSSIPVDDPQRRRPDIEVAKIQLGWEPIVKIRDGLHKTVDYFREYVDSSPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU42</accession>
    <name>A0A074ZU42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166893.1">
        <property type="nucleotide sequence ID" value="XM_009168629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU42"/>
    <dbReference type="STRING" id="6198.A0A074ZU42"/>
    <dbReference type="GeneID" id="20318197"/>
    <dbReference type="KEGG" id="ovi:T265_04011"/>
    <dbReference type="CTD" id="20318197"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7925" checksum="1593F3E8C1B587B8" modified="2014-10-01" version="1" fragment="single">ADSKVLRLLVGNKCDLEPKSAVPTATAMALADELHMPFLETSAKDATNVEQAFFKMAQQIAANATSMPGMQSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVU1</accession>
    <name>A0A074ZVU1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597256">
        <property type="protein sequence ID" value="KER19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176961.1">
        <property type="nucleotide sequence ID" value="XM_009178697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVU1"/>
    <dbReference type="GeneID" id="20326051"/>
    <dbReference type="KEGG" id="ovi:T265_11883"/>
    <dbReference type="CTD" id="20326051"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="21137" checksum="D2F7356E402BED16" modified="2014-10-01" version="1">MAQWVAEDAETVTPCCCVRPHGHLTIRLVESDYLEGSPEVQHSPLVVGMTFSNDMYERFRQNSSHPFAMSACTTLIWPRAKAPNSTNNDSAYVVDGLTAAALGAGRILQLQFLLYNRTPVFQLALADSQAPAYISYGSETTAIENLQLSAAYRDCLTDKHQGCAALLPYMSQIVTCNPSWRFVQPTHYIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWA6</accession>
    <name>A0A074ZWA6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164510.1">
        <property type="nucleotide sequence ID" value="XM_009166246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWA6"/>
    <dbReference type="STRING" id="6198.A0A074ZWA6"/>
    <dbReference type="GeneID" id="20316275"/>
    <dbReference type="KEGG" id="ovi:T265_02087"/>
    <dbReference type="CTD" id="20316275"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="102624" checksum="C0DF4FEA5C8C2D6D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWY7</accession>
    <name>A0A074ZWY7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168381.1">
        <property type="nucleotide sequence ID" value="XM_009170117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWY7"/>
    <dbReference type="GeneID" id="20327864"/>
    <dbReference type="KEGG" id="ovi:T265_13697"/>
    <dbReference type="CTD" id="20327864"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="189"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER27865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="442" mass="48752" checksum="72A285DA528F9C56" modified="2014-10-01" version="1" fragment="single">LVPATGPRKPPVDGTIKDYNGVTIWSKKERVDRWDEFFEQRLWWPPAATYLEPIMDVEPWAVNVETPVVSEAYDRICSLKRRRTSGPDYLSPALLKNGSKLPSGIATVYVGQPLDTIKVKMQAFPEVYSDAWKCFKVTLKKDGIVRGLYAGTVPALVANIAENAVLFCALPPSQHLVGVLCGKQPHEHLTNLQHAFAGSLAAFWSSLTICPTELVKCKVQSIREMTELGQLQIKPKETGPWSVTRMIFREEGLVGFTRGLSATFAREVPGYFFFFGGYETCRSLFARHRGNRDHLNTAEVAVCGGVGGCMLWTAIFPFDVIKSRMQIGHVEAAVPVSSTPGLSAKIPVTGETNVYASLHQSAPAVKPPSFFHLLFRIARHEGNFHTCLAASTWLIMVGYPGLVGILSSSTMKSRCRKEVSVPSIVDSDPPFCGHFRPVEPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWZ3</accession>
    <name>A0A074ZWZ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168385.1">
        <property type="nucleotide sequence ID" value="XM_009170121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWZ3"/>
    <dbReference type="GeneID" id="20327868"/>
    <dbReference type="KEGG" id="ovi:T265_13701"/>
    <dbReference type="CTD" id="20327868"/>
    <dbReference type="OrthoDB" id="10068383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705549" description="CCHC-type domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54539" checksum="1FB08B56AFA9859E" modified="2014-10-01" version="1">MTCVCWSFSALYLSTTIVCVESACNKWIRFPGAINSKVKRLSGVEQLSRAVHSRKSDSIVFHWGSNWRSRRSDRFVSRSSDRVVGVKVAEVAATLMFNEFLDGRHKCAVCMQVTQHGTRADSIPQTSKCLAAILLEGRTRAGILAGCPSLDRDSQDAKVRFEPRTFWSCTKSSAVCCQIAALRLSVQNKTARWARWPKWLEREFTDRKVRGSNPTPATRLPLSRLGQPGSIPALVLPSGGMAARHRKGATAERFLLRGAFITILQRLLEHESLYFKTACGYAKSLELARKQSLSFLPNNRLPCATVSNDPPKYSHSRASPHEQTTAASVRAFMFLLYVRHPRNKCPAKAATCKNCGKKRHFQKACRSSTGPRNTSSDSTALSCVTAAVSECLKEAVTDEKANGVPLRALVDNGSSESFISKHAVRLNKRSILPSSSGTTLASIRHKSFTLVHRFLTLQHKHNKYPSFKFSVLRDLCTDILLGRDFLRLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX68</accession>
    <name>A0A074ZX68_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597141">
        <property type="protein sequence ID" value="KER19774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176482.1">
        <property type="nucleotide sequence ID" value="XM_009178218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX68"/>
    <dbReference type="GeneID" id="20325707"/>
    <dbReference type="KEGG" id="ovi:T265_11539"/>
    <dbReference type="CTD" id="20325707"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="9035" checksum="3DAE511A0F7AA62A" modified="2014-10-01" version="1">MYLYKCQHGKQKYTSKDLFKRGRVISMSDVQNSCRGLKWINKKKQCADIQLRTNLVLTAKDDLLPLNTLQKAVPFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYM3</accession>
    <name>A0A074ZYM3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597072">
        <property type="protein sequence ID" value="KER20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175973.1">
        <property type="nucleotide sequence ID" value="XM_009177709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYM3"/>
    <dbReference type="GeneID" id="20325302"/>
    <dbReference type="KEGG" id="ovi:T265_11134"/>
    <dbReference type="CTD" id="20325302"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="15170" checksum="3F28887E7E06FAE3" modified="2014-10-01" version="1">MIGVDEYPGKFKKSRSGKDTLVSRWQRPVSLRSYKKIHHVLYLLVRQSVVSAADPLQCPVPEKRLTEENTTATFRTSDNPMSSVLRLYMYRDILKIVANETPCGLVQRIQLPGNITGERFSWFPDDCLEKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZB4</accession>
    <name>A0A074ZZB4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597048">
        <property type="protein sequence ID" value="KER20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175732.1">
        <property type="nucleotide sequence ID" value="XM_009177468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZB4"/>
    <dbReference type="GeneID" id="20325116"/>
    <dbReference type="KEGG" id="ovi:T265_10948"/>
    <dbReference type="CTD" id="20325116"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15517" checksum="87F03EA011CBD71E" modified="2014-10-01" version="1">MSANNNQNRRVQETYVSRHGLNNPHLLDVSEGGIENKTEMLDSIHELILLREEAEARYARRSLSVNQRQTTVDVLKPDGNCLYSPMARIAILEGSELWHSTVRLSFGEVTDDIHARSKLSVLASGGGCARRCGEIANQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZK4</accession>
    <name>A0A074ZZK4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_15278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KL597039">
        <property type="protein sequence ID" value="KER20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175653.1">
        <property type="nucleotide sequence ID" value="XM_009177389.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZK4"/>
    <dbReference type="GeneID" id="20329443"/>
    <dbReference type="KEGG" id="ovi:T265_15278"/>
    <dbReference type="CTD" id="20329443"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="782"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1363"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1436"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1627" mass="180874" checksum="FBB7FCDC8E2D2DAB" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0B9</accession>
    <name>A0A075A0B9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597014">
        <property type="protein sequence ID" value="KER20869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175394.1">
        <property type="nucleotide sequence ID" value="XM_009177130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0B9"/>
    <dbReference type="GeneID" id="20324844"/>
    <dbReference type="KEGG" id="ovi:T265_10676"/>
    <dbReference type="CTD" id="20324844"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15905" checksum="4C4D4E4D4D956E1C" modified="2014-10-01" version="1">MNVDTAKQWSLDWHIPLNDEKCVHMSFGGDPANAFVMRGEKGPENIIRIDAKKDLGIWVSSNLSFSLHRQKSAQNAFAILQMIRRTFSRITRMDFQTLYRAYLTFNYPPPRSQRPFVARVFRQTQLFHWPGFPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0J7</accession>
    <name>A0A075A0J7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_02003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164415.1">
        <property type="nucleotide sequence ID" value="XM_009166151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0J7"/>
    <dbReference type="GeneID" id="20316191"/>
    <dbReference type="KEGG" id="ovi:T265_02003"/>
    <dbReference type="CTD" id="20316191"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="262" mass="29691" checksum="C0DA8A211F81052B" modified="2014-10-01" version="1">MSVRVYETTEGQEDDSEANACKLQLVQYEESISKDFCAGCKIKLAHLFSSKVFHLTIVILCCLDGLLVICVLLLEIEALKLKSSSDLRPKLVNVQFAIECCSVAIVFLFVIEIPFKLWIFGCRMFFHNWLEIIDALVCLVSFAADTYSIIQHTLHHYTNTDRPQSYMKTSPSNATQEMMERFPVEESTASNTIVDAAALLILFRLWRVVRIINAIVISVTTGQEQSSKVLRASLKTSQDRVAQLEQILRENFISFPEQPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0V7</accession>
    <name>A0A075A0V7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163294.1">
        <property type="nucleotide sequence ID" value="XM_009165030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0V7"/>
    <dbReference type="STRING" id="6198.A0A075A0V7"/>
    <dbReference type="GeneID" id="20315275"/>
    <dbReference type="KEGG" id="ovi:T265_01087"/>
    <dbReference type="CTD" id="20315275"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="340"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="737" mass="84942" checksum="2029245DD8EBC9ED" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A169</accession>
    <name>A0A075A169_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162682.1">
        <property type="nucleotide sequence ID" value="XM_009164418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A169"/>
    <dbReference type="GeneID" id="20314778"/>
    <dbReference type="KEGG" id="ovi:T265_00590"/>
    <dbReference type="CTD" id="20314778"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8888" checksum="900082BB8C5790B1" modified="2014-10-01" version="1">MFEVSSTLGTLMRRWMLRNAAEVIKHCRLFHTERDEAVTDANEDTFLDGMNDATTDVRAEFLDINLVVGADELLDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A199</accession>
    <name>A0A075A199_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166961.1">
        <property type="nucleotide sequence ID" value="XM_009168697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A199"/>
    <dbReference type="STRING" id="6198.A0A075A199"/>
    <dbReference type="GeneID" id="20318248"/>
    <dbReference type="KEGG" id="ovi:T265_04062"/>
    <dbReference type="CTD" id="20318248"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="47726" checksum="D61AFDEEF105C50E" modified="2014-10-01" version="1">MRILALASILPRAENIKSSATPLLHLCLSGERQPLTGKKGKLGQKIRSRVSIRDSVNPCYLAALMMRVGFRLIWSAFLTVIASCVAYFFYDTYSVYSNAPEITFPSEADVSNKLTNMEFLSTLPYHGCESLVYHDGALYMGAVEGKILKMDDSGLHVLAQFGDTNCASSHTCGRPLGMRLSLDHKELIVADTHLGLFSVSLIDGTHKKLFPLDGTFKVTCFNDFDILPNGTVILSESSTEFPMDDIMNIIFSARPSGRILSIDLATGEWRQLMDGLAFPNGVQLHRDGKSVLVADTVTSRIHRVPLDGSTPTLFGGELPGVPDNIRASPRGGYWVPVANLKDTFISHLTQRTRQVPALRWIPPMLVKLPVFERLRLSKSAMILRLNDDGEVIEVLRDPTNRVRNVAEVCEHDNVIYTSTYFLPHIGRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1C1</accession>
    <name>A0A075A1C1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596990">
        <property type="protein sequence ID" value="KER21154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175105.1">
        <property type="nucleotide sequence ID" value="XM_009176841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1C1"/>
    <dbReference type="GeneID" id="20324630"/>
    <dbReference type="KEGG" id="ovi:T265_10462"/>
    <dbReference type="CTD" id="20324630"/>
    <dbReference type="OrthoDB" id="10035051at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="303" mass="34392" checksum="E0F0737A9F517643" modified="2014-10-01" version="1">MNKVELNFEEYWKVQQQTVPSRSPRDEEATKLLPRCDCVVAVNTAPDDTTIFALNAPLDIILPYCDQLVPTAAPSVGRIYQLVHHEVFHRPFSYTLSLSLFARCLNTAESSMLDCLKPPGNTGNLQKYTLKCLVISYSSHGYPHYTSRNTASKKISQDVDVQKTKPEKKALAAQISSGRNQDDTHYAAVETNTSRPGDSPSGNSKKLLNRRRNISENRIADRTQTNNAERNAILSRMRNQSENLRTIKIFKPTGRKLAFKNEEDRLLFEKQRTVIYALNAIMRDAEHANYEAFIQSKHDAKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1G2</accession>
    <name>A0A075A1G2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">dihydropyrimidinase</fullName>
            <ecNumber evidence="8">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="8"/>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162764.1">
        <property type="nucleotide sequence ID" value="XM_009164500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1G2"/>
    <dbReference type="STRING" id="6198.A0A075A1G2"/>
    <dbReference type="GeneID" id="20314860"/>
    <dbReference type="KEGG" id="ovi:T265_00672"/>
    <dbReference type="CTD" id="20314860"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000001">
        <property type="entry name" value="Dihydropyrimidinase like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="71"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="588" mass="63738" checksum="5839420FF2758A07" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1R1</accession>
    <name>A0A075A1R1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596974">
        <property type="protein sequence ID" value="KER21344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174915.1">
        <property type="nucleotide sequence ID" value="XM_009176651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1R1"/>
    <dbReference type="GeneID" id="20324484"/>
    <dbReference type="KEGG" id="ovi:T265_10316"/>
    <dbReference type="CTD" id="20324484"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11876" checksum="0F04C473291E77D2" modified="2014-10-01" version="1">MLHRTSRVARQPHQLADGVQSPDLQDKSFRSVRQRTVNTPLIMKIGQTNFIQLERRLWVTQLLDDSAIHRRPVMQDPLVLTESLNRTRCGSVEPLHIIAFPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1U9</accession>
    <name>A0A075A1U9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162996.1">
        <property type="nucleotide sequence ID" value="XM_009164732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1U9"/>
    <dbReference type="GeneID" id="20326818"/>
    <dbReference type="KEGG" id="ovi:T265_12650"/>
    <dbReference type="CTD" id="20326818"/>
    <dbReference type="OrthoDB" id="10064127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="8108" checksum="3477310C0D023447" modified="2014-10-01" version="1" fragment="single">MERFIMPAEMEPLDVNSTARDVEEYLERFDIWRLTKSDMDDKKLTAYFLHFVGKDAHTLIKNLVWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2C4</accession>
    <name>A0A075A2C4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596958">
        <property type="protein sequence ID" value="KER21549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174696.1">
        <property type="nucleotide sequence ID" value="XM_009176432.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A2C4"/>
    <dbReference type="GeneID" id="20329229"/>
    <dbReference type="KEGG" id="ovi:T265_15063"/>
    <dbReference type="CTD" id="20329229"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21608:SF7">
        <property type="entry name" value="KINESIN-LIKE PROTEIN CG14535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="272"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="968"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="855"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="981"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1317"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1373" mass="152000" checksum="4FE46BC275DBC8D5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A322</accession>
    <name>A0A075A322_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162467.1">
        <property type="nucleotide sequence ID" value="XM_009164203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A322"/>
    <dbReference type="GeneID" id="20314618"/>
    <dbReference type="KEGG" id="ovi:T265_00430"/>
    <dbReference type="CTD" id="20314618"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12813" checksum="ACED56D936B70F4D" modified="2014-10-01" version="1">MRILLDQLRLGLAHAYEITVKKIHKNDVAFFAEKPACARTDLVFPKGFGVCFSWNPGSVGQKGNPRITPPLHHFAMHCESKSRCAGERQPLTDKNKTHPGNFGKSLDPVYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3L2</accession>
    <name>A0A075A3L2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="19">3.1.-.-</ecNumber>
            <ecNumber evidence="19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">T265_12528</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="19"/>
    <dbReference type="EC" id="3.6.4.12" evidence="19"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162428.1">
        <property type="nucleotide sequence ID" value="XM_009164164.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A3L2"/>
    <dbReference type="GeneID" id="20326696"/>
    <dbReference type="KEGG" id="ovi:T265_12528"/>
    <dbReference type="CTD" id="20326696"/>
    <dbReference type="OrthoDB" id="306218at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="21">
        <location>
            <begin position="393"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="1033"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="1144"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="23">
        <location>
            <begin position="1236"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KER33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1533" mass="168284" checksum="2F0B5D193F5ABFC2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A461</accession>
    <name>A0A075A461_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174110.1">
        <property type="nucleotide sequence ID" value="XM_009175846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A461"/>
    <dbReference type="STRING" id="6198.A0A075A461"/>
    <dbReference type="GeneID" id="20329100"/>
    <dbReference type="KEGG" id="ovi:T265_14934"/>
    <dbReference type="CTD" id="20329100"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF17">
        <property type="entry name" value="PROTEIN SIMILAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="34932" checksum="2FD39CED9ABDF51E" modified="2014-10-01" version="1" fragment="single">NGHPGTHKRKERSREAARCRRNQENELFKALARLLPLHPEIAPQLDKASIIRLVVSYVKLKTFLGEMNHIYMSAECDDRSNSTYECGNSTVMDWMLSELLQKICLQIKMAYSEDYKICWYLGIAVILQPIRVSELSTSCHTYVLRLTDDLCIQYIENSHYQQTQLSWSLLSSWMRAPRRTKSTVRDIVRHGPAPPLMALVHPTQCLQCIVPVSNVQLPTPTPQIIGLGNLAVSQLLCHLLVAWPPASEITSLPVMLHKTLYQHVDPFELNNLRSSHLESELETRGFSPMFKLHFPKHSMEATFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A560</accession>
    <name>A0A075A560_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162852.1">
        <property type="nucleotide sequence ID" value="XM_009164588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A560"/>
    <dbReference type="STRING" id="6198.A0A075A560"/>
    <dbReference type="GeneID" id="20314927"/>
    <dbReference type="KEGG" id="ovi:T265_00739"/>
    <dbReference type="CTD" id="20314927"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="373" mass="41338" checksum="8016D4A2E154237B" modified="2014-10-01" version="1">MVLGLCPSDPRTLTIFRLNRFNGLPTTVADGLGCCGLNGSSIWYARQKLEALGLITSQPYISKFQSQPMATGLLLHHWRYYRHFPFPNATLIKKVLQLLQGSPKKAHTSPYLRNEVGLTYKSFRRLLHFASRQGFVTTSDSTMKEACAFFKNKDPESIATEDLQMFAQENAIPRCGPQAPLVIVHLKNSANIEAWFSSFGAVKGIPPGARSEGESEEEEEAVEEVVDTESGDVASSVAPTGLGPSSEGNSSFHNLTPSGVAELQSDSKSSSLVPTLRACEKTLAMAPSVNGEESLMVQFARLMLPQEITMASLLKLTRLNYFFSRRLLRAFDNLCAVRTTKRSLRATINTTSKVRKTLHNFQCLSLDRKWRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A585</accession>
    <name>A0A075A585_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596891">
        <property type="protein sequence ID" value="KER22579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173683.1">
        <property type="nucleotide sequence ID" value="XM_009175419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A585"/>
    <dbReference type="STRING" id="6198.A0A075A585"/>
    <dbReference type="GeneID" id="20328987"/>
    <dbReference type="KEGG" id="ovi:T265_14821"/>
    <dbReference type="CTD" id="20328987"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27864" checksum="3F147E9313366CDF" modified="2014-10-01" version="1" fragment="single">YWQFVPCGSGLFLHTELLAGLTSLNSIGRTRVSHRDSLTMNTEPVATFKLVLVGDGGTGKTTFVKRHISGEFEKKYVATLGVEVHPLDFHTTRGRIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIQDRKVKAKSITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVEMPAMQPPELTMDAALAKQYEQELQVSARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5U9</accession>
    <name>A0A075A5U9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162660.1">
        <property type="nucleotide sequence ID" value="XM_009164396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5U9"/>
    <dbReference type="STRING" id="6198.A0A075A5U9"/>
    <dbReference type="GeneID" id="20326740"/>
    <dbReference type="KEGG" id="ovi:T265_12572"/>
    <dbReference type="CTD" id="20326740"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF77">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="1">
        <location>
            <begin position="334"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="68710" checksum="E3216ECFA5981B0A" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A616</accession>
    <name>A0A075A616_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NHL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162525.1">
        <property type="nucleotide sequence ID" value="XM_009164261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A616"/>
    <dbReference type="STRING" id="6198.A0A075A616"/>
    <dbReference type="GeneID" id="20326705"/>
    <dbReference type="KEGG" id="ovi:T265_12537"/>
    <dbReference type="CTD" id="20326705"/>
    <dbReference type="OrthoDB" id="27136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14960">
        <property type="entry name" value="NHL_TRIM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057750">
        <property type="entry name" value="TRIM2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF57">
        <property type="entry name" value="BEE-MILK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17170">
        <property type="entry name" value="DUF5128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="2">
        <location>
            <begin position="315"/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6K9</accession>
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                <person name="Nagarajan N."/>
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                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
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                <person name="Maleewong W."/>
                <person name="Yang X."/>
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                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <begin position="673"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
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        <location>
            <begin position="763"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1241" mass="138668" checksum="84182E726D1953E9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075A877"/>
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    <dbReference type="OrthoDB" id="10025028at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
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        <property type="entry name" value="WITHOUT CHILDREN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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            <begin position="550"/>
            <end position="659"/>
        </location>
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        <location>
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            <end position="774"/>
        </location>
    </feature>
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            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER31925.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="STRING" id="6198.A0A075A9J4"/>
    <dbReference type="GeneID" id="20322318"/>
    <dbReference type="KEGG" id="ovi:T265_08139"/>
    <dbReference type="CTD" id="20322318"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DLC_sf"/>
    </dbReference>
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        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
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        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="469" mass="52817" checksum="33F9D5BC58DC3E35" modified="2014-10-01" version="1">MLHSFYLRREPNCVKHSVSSFLSTRHQVNMSSPRTKSEEYLEKVSVPDGTEKVINIKKVQQSASIQLSKTTPLSVHTGYASNMRTSELHVEEMKSQVRRRSKSSGQKKSGRDHSRRSQLIVRTGDGASGSRRRVVSCVDLTAPEPAETHLVHAITGEEESTLTGGTHRAAKSIRKIRGRHRDEWLSSKAEEVPQSGWRYSGIFAPDTGRHRPSSRTKHSRNSRAQISAQASPTPAAWSPMNYMSPACPRCSSLNVNQERTNPYPIPVMNGIYLPYAPYSVENFPSQMRSGSVQQHHHHSHVRHQQQEQFYESPLQHSPQFHHHHHHHHRPQHSPPYPSPYGTKYMPIPQGRPVGFSPNVEDLRHAEVNGTDRTVDLMEIEYAADSAGEKDTYLSSDALNLIVKLAKSFNKSTQRLEEIAKQLKLALDARLGEKWHVVIGDDSFGSNLASLPGALANFKLGRNVFLVWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABL3</accession>
    <name>A0A075ABL3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163105.1">
        <property type="nucleotide sequence ID" value="XM_009164841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABL3"/>
    <dbReference type="STRING" id="6198.A0A075ABL3"/>
    <dbReference type="GeneID" id="20326827"/>
    <dbReference type="KEGG" id="ovi:T265_12659"/>
    <dbReference type="CTD" id="20326827"/>
    <dbReference type="OrthoDB" id="6265577at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="425" mass="49262" checksum="775A32F689E40CC6" modified="2014-10-01" version="1" fragment="single">DSSRVQDILRQIEDVIRGFRKDATDIAEALQHEETDLWQACLLSEKRIASWNEEDSAKALENNTARTIHRSRSVPWLDVTKDLTPEVVEYEHFLESTGGRFGGWTDKEHAIFLKFFNRPATTSVSKSGDSVKEEDKQSGCAVDSGSAEKRRQFGDATISSQIDNTGEDKQLSRVLILHRKVSLLIGTKSPEEVLAHEAWWKRLRELEKSKRQAIQKWRTSKQTATASDNKDSSAQSNTVTPMTKAEMEAKRTAVEQWRQQQEKQRKQKKEAEIAEEINNAEKQKQLVQQHREESKKKISEYQTAKDLRELQMACHLAEQAEEERIIVRQRLNESADRIISRNQSLSNRQRARKESLKQTQLAPKSKQCKIVDKQVYAERDFQRLTQLTDSWKQRLEAPREPCSIQTGLNPESRPIRMKPQWMRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADS3</accession>
    <name>A0A075ADS3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170062.1">
        <property type="nucleotide sequence ID" value="XM_009171798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADS3"/>
    <dbReference type="GeneID" id="20328216"/>
    <dbReference type="KEGG" id="ovi:T265_14050"/>
    <dbReference type="CTD" id="20328216"/>
    <dbReference type="OrthoDB" id="6243116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="446" mass="50419" checksum="7ADE77323834E1F6" modified="2014-10-01" version="1">MVKKVSILESFSTVDGGRAKELQLADKKKNPRRTVTHSSSAEQYLENLWGADAVNYFFNPTFTPTGKTSSAEEKATRIAPFDQLTIGGYPNGLLHGSRVPFHPELKPWLLHPIEPELIRRRKSECARRPSLALLTSERRMSVLKPVGVSGLIDTLRLHAGVNPGATNVWEVLRSRSYKLLQKLEKADEKSNETFAVFTREYALSERKKPPLCDFIRTNTSGHLAQTMRHLKAHGAEKQFRKTKAMVAWTERNQEHLKMVLQQHDIRDKLERCKLENRMERHDSDAKKRESKTGVVTPAEGPTVFQQTGGPGIQLASKPTVDDFLPENWSDTSIQKTNRMIDNRLVSKLNSVRTGAKTEEKCMCVEKFSQKLQYLKCHKTLSGGKNIFTKGEEVSMSSASDVLARTQSKKIQTLGAFPDDTTVEPLCWSQLIEQQTQAKQQDECEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE06</accession>
    <name>A0A075AE06_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169835.1">
        <property type="nucleotide sequence ID" value="XM_009171571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE06"/>
    <dbReference type="GeneID" id="20320520"/>
    <dbReference type="KEGG" id="ovi:T265_06338"/>
    <dbReference type="CTD" id="20320520"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9438" checksum="61E2693463DCF6E3" modified="2014-10-01" version="1">MDTSEILFYLPPHYAFVRRPPNVAENELRMRSAVKTIQMPSLGNQLRFANYDTTECCITVLSNDPLFRNAILKSSQNYPAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEY9</accession>
    <name>A0A075AEY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169073.1">
        <property type="nucleotide sequence ID" value="XM_009170809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEY9"/>
    <dbReference type="GeneID" id="20319918"/>
    <dbReference type="KEGG" id="ovi:T265_05736"/>
    <dbReference type="CTD" id="20319918"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12185" checksum="55FAFA7538A45E8E" modified="2014-10-01" version="1">MPVDRLPRRALFAQPREGMLNLDVSSDELTKVILSSAPMDLQSLNMSITIQEEAFEVVERFTVTDEVNAQICKANLRHLCCQTDVSLNRKGLVYQATVRIVWLCGCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFJ7</accession>
    <name>A0A075AFJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168394.1">
        <property type="nucleotide sequence ID" value="XM_009170130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFJ7"/>
    <dbReference type="GeneID" id="20319368"/>
    <dbReference type="KEGG" id="ovi:T265_05186"/>
    <dbReference type="CTD" id="20319368"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="287" mass="32180" checksum="E3221BE6785889E8" modified="2014-10-01" version="1">MKIVSTQCRRHAEELGWYLRLADKLYSSCDGQNTLSSTLKKHSPSRRAIINKQGGKPTRRNRHLVDPANSSDSSIYVNSEAYTLWSKQTVGLFHLTRIDSSTFSGWSQSNIVLTDRVLSLLELHKPTHVEALFPKKLIVYRSIKSRFAHLSSHFASRGGNIRSLLCWMHRENTYTKETAAKLQNQSSTEYSYSLLQNTRTVGAVAKQPSSSVLPFACICSKVNFRMSPACAGRVVVTNLPRMSDVRISNPFIAIGYALLMSSNTSRTRVHRFSPSVKTIARGQVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG79</accession>
    <name>A0A075AG79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167795.1">
        <property type="nucleotide sequence ID" value="XM_009169531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG79"/>
    <dbReference type="GeneID" id="20327739"/>
    <dbReference type="KEGG" id="ovi:T265_13572"/>
    <dbReference type="CTD" id="20327739"/>
    <dbReference type="OrthoDB" id="10332503at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="375" mass="41663" checksum="2C960610D475B28B" modified="2014-10-01" version="1">MCKVYSLMETGSTLLSERKLPRFSVSANFLKHFTESCERDRPEFAKLPMHQNVIQTKMHAPAILSKHLTTYSNGFVLHTNNTNGVSTTSSACSPKRQLNQSPTASECSLTSAAPRPKRSSTESQVEELVLLCWEQQGELGDIYEAVEPANHTPGKKDSDAKSPSADHLSSDPLSSDGSPEENCVSDNCLPKSTDHESEEDQSRVEQMTSNIDLCRRMDEMVGELTQKMIKRDKGVQSEMTSLPTSKMCKHMTDDISLQTKHTTDESGTYVYLESPPSYPTPYGGQLGIPTSRSLHDSLSQATVRSHDNKTSTSNTALHKTNRKLPLVFGSSLFRTTSKERRPDPGGTLRQHSFRQSCRSQDRKLKADKFSLNRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGT7</accession>
    <name>A0A075AGT7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13456</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167222.1">
        <property type="nucleotide sequence ID" value="XM_009168958.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AGT7"/>
    <dbReference type="GeneID" id="20327623"/>
    <dbReference type="KEGG" id="ovi:T265_13456"/>
    <dbReference type="CTD" id="20327623"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="668"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1461"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1775"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1802" mass="203490" checksum="0F64A108AEBEB77B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHE5</accession>
    <name>A0A075AHE5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166462.1">
        <property type="nucleotide sequence ID" value="XM_009168198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHE5"/>
    <dbReference type="STRING" id="6198.A0A075AHE5"/>
    <dbReference type="GeneID" id="20317843"/>
    <dbReference type="KEGG" id="ovi:T265_03656"/>
    <dbReference type="CTD" id="20317843"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="19932" checksum="0991A669F0BDCE51" modified="2014-10-01" version="1">MTEKTPIIPNKRLQQTQAQVNEVVDIMRVNVDKVLERDKNLSELDGRAAWPTILSPRDMWEQGIFLLDVPRLFAKNAIAVSNVNRQSKPPVTQNLFHIFGKLEMDDEYAIPELPNFAVVTDERQNSLEDNKADEKADDELDQIIGEEQVPQKGAKLLSGLYGTYGDYGPAAVSLVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHG2</accession>
    <name>A0A075AHG2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166423.1">
        <property type="nucleotide sequence ID" value="XM_009168159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHG2"/>
    <dbReference type="GeneID" id="20317811"/>
    <dbReference type="KEGG" id="ovi:T265_03624"/>
    <dbReference type="CTD" id="20317811"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9849" checksum="AE9FF912E3BD8499" modified="2014-10-01" version="1">MAQVDRQGEKTSKNMSTKVQNTPFKRLRYIFKKDPTLLLPEMVSSEYPACWSTEAEQHQSFSQLTPKYCNPPRQVDPDATPHHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHY0</accession>
    <name>A0A075AHY0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165543.1">
        <property type="nucleotide sequence ID" value="XM_009167279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHY0"/>
    <dbReference type="GeneID" id="20317103"/>
    <dbReference type="KEGG" id="ovi:T265_02915"/>
    <dbReference type="CTD" id="20317103"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14717" checksum="59B63C6DE44EF807" modified="2014-10-01" version="1">MSMEQVERKCFPPVNESIDQNVNQGHQFAQNLGAPSEKNLRHSPKQARNLDSEMPAGNPCSQSTFQYHVRVENGNSDDAKSVDRSHTMEHGQLTSTTAANSALSNVAPPQTLLCQMQNYRRKEEGLRCGVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIP3</accession>
    <name>A0A075AIP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_01913</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164303.1">
        <property type="nucleotide sequence ID" value="XM_009166039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIP3"/>
    <dbReference type="STRING" id="6198.A0A075AIP3"/>
    <dbReference type="GeneID" id="20316101"/>
    <dbReference type="KEGG" id="ovi:T265_01913"/>
    <dbReference type="CTD" id="20316101"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22028">
        <property type="entry name" value="HMG-box_SoxA_SoxB_SoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="512" mass="56595" checksum="AE5CAB09EEF25DEF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIV8</accession>
    <name>A0A075AIV8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163861.1">
        <property type="nucleotide sequence ID" value="XM_009165597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIV8"/>
    <dbReference type="GeneID" id="20315726"/>
    <dbReference type="KEGG" id="ovi:T265_01538"/>
    <dbReference type="CTD" id="20315726"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7707" checksum="A690766A91409337" modified="2014-10-01" version="1" fragment="single">DKCSSHQSGWPHLPYFPKQGDGSNRTNCGITTNVGWIDVCLDRCSAEIRRPIHRTSEGGRKGGGENIAAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ60</accession>
    <name>A0A075AJ60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163423.1">
        <property type="nucleotide sequence ID" value="XM_009165159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ60"/>
    <dbReference type="STRING" id="6198.A0A075AJ60"/>
    <dbReference type="GeneID" id="20326887"/>
    <dbReference type="KEGG" id="ovi:T265_12719"/>
    <dbReference type="CTD" id="20326887"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="216" mass="24595" checksum="2C06AE3DE5A3ED90" modified="2014-10-01" version="1" fragment="single">VTTISRNPADPGSTGLNLREESQLLYNKYYPNLNVSGIHEAPALRSESSATREWIMTALRSSTGQDRLFAMAYLVTTHPMLSLRYLDSLIASIVPSKQRDCIRAIEVTHQLFIRSLLPSQRILVPFDLRPVHPLNGVSVAQRSEILCLWYFEDQLKSKYLHFIKALERLLLSDTVEGFKRKALSKSCFLIFFQCVDALSDLAVKSPENRGVWLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJW0</accession>
    <name>A0A075AJW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162284.1">
        <property type="nucleotide sequence ID" value="XM_009164020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJW0"/>
    <dbReference type="GeneID" id="20326664"/>
    <dbReference type="KEGG" id="ovi:T265_12496"/>
    <dbReference type="CTD" id="20326664"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="400" mass="45589" checksum="A5256E1BC65DDE20" modified="2014-10-01" version="1">MYTACQKTACLSELFPPSPVKRLTGGKCMACQRRTKTLTSTNSNRRLPPPWMGTPGFKSPMVNNMGRNGPIARSVALVDQSYRLQCVVTQIPNKLNMLPPPRFGCMFQLPVFRFVRIDPALALVEVASIISLFRNKCPSLQRPTIVAFLHLRCFLSIDRQKLWQFRYECTTYKLLVQDWVRSNPNLMLAGELIDLVAAYDPAEWRKTKPFPGLGSQGQRSLTSDICDQLVCQDKSVLCHCPICPTLWIRGGVAVCGGSSENVLDRPCLRSFPRAWLKHQISNAEVCHMVIQKVHCSSIDQLITICRLRCLGHLDNAVTKSEIGFGILRYVSILSPMRYVLSISNTQSDQLLESYLRQRSFNILHQWRRRQWRLFTCCIGPKSSGTWHHSFSLTGFCRLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YT56</accession>
    <name>A0A074YT56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL627493">
        <property type="protein sequence ID" value="KER17981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178272.1">
        <property type="nucleotide sequence ID" value="XM_009180008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YT56"/>
    <dbReference type="GeneID" id="20330543"/>
    <dbReference type="KEGG" id="ovi:T265_16378"/>
    <dbReference type="CTD" id="20330543"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER17981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6662" checksum="AE23FF73E60D229D" modified="2014-10-01" version="1">MMGDDLQQLLSTDMTFVNVVKGPYWETSFDCWLQSRSHLVPFSAGYLFSTRGLALGITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVW0</accession>
    <name>A0A074YVW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597530">
        <property type="protein sequence ID" value="KER18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177347.1">
        <property type="nucleotide sequence ID" value="XM_009179083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVW0"/>
    <dbReference type="GeneID" id="20329923"/>
    <dbReference type="KEGG" id="ovi:T265_15758"/>
    <dbReference type="CTD" id="20329923"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7493" checksum="52E70DA984476985" modified="2014-10-01" version="1" fragment="single">MNVRESSHFQTTGRGEFLLRLNQTRQVELFVDPDRGYSGSELMSTTQIPMACLDCKQSDGGRKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW95</accession>
    <name>A0A074YW95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597428">
        <property type="protein sequence ID" value="KER18958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177296.1">
        <property type="nucleotide sequence ID" value="XM_009179032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW95"/>
    <dbReference type="STRING" id="6198.A0A074YW95"/>
    <dbReference type="GeneID" id="20326250"/>
    <dbReference type="KEGG" id="ovi:T265_12082"/>
    <dbReference type="CTD" id="20326250"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="48684" checksum="8DEC5257A348D66F" modified="2014-10-01" version="1">MTMDLEINAEELNNLLMGSSDGFVKKSQKRKKTLNHLGNTKRTKTSDEVSSSLAEDPNSAVRTSREENAFEKTIELDPKVAEEVVKRIEQKNSRTLCVSGLPPKTNLHLMEQLIPDIHTARIQWNTITHKCTGTVYVEFGSADMVEQYKAKLDGMTFQHKTLTAKTGNFLPESADRYDCKTLVLHGLHYKTHVGEIAKRFPSATSIKFSSDHKKWDRQRPALAYLTFPTPQDALLAFDTRQSCTIRRRRFNITWFLRKTEEQQHPPRKCLFVRGLKKSVTETDLQSVFPQATSMSIQPKTGEAYLHYDLEEDCVLDWQNARHLQLFGRKIQVTFDTSVRKPIALSMLHPGSSQVTANSGTFGKKREKIRGPSVNASESTKLAHKKRKKKHHLESLASSKPSLLSAQVDLSRKPTKLKHKSKLFTGSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWR8</accession>
    <name>A0A074YWR8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597325">
        <property type="protein sequence ID" value="KER19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177136.1">
        <property type="nucleotide sequence ID" value="XM_009178872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWR8"/>
    <dbReference type="GeneID" id="20326165"/>
    <dbReference type="KEGG" id="ovi:T265_11997"/>
    <dbReference type="CTD" id="20326165"/>
    <dbReference type="OrthoDB" id="6259957at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="548" mass="61912" checksum="1B81AB6243A01100" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWV2</accession>
    <name>A0A074YWV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597260">
        <property type="protein sequence ID" value="KER19276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176973.1">
        <property type="nucleotide sequence ID" value="XM_009178709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWV2"/>
    <dbReference type="STRING" id="6198.A0A074YWV2"/>
    <dbReference type="GeneID" id="20326060"/>
    <dbReference type="KEGG" id="ovi:T265_11892"/>
    <dbReference type="CTD" id="20326060"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="551" mass="62300" checksum="DA617FB6B1599504" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYJ1</accession>
    <name>A0A074YYJ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597125">
        <property type="protein sequence ID" value="KER19866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176391.1">
        <property type="nucleotide sequence ID" value="XM_009178127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYJ1"/>
    <dbReference type="STRING" id="6198.A0A074YYJ1"/>
    <dbReference type="GeneID" id="20329604"/>
    <dbReference type="KEGG" id="ovi:T265_15439"/>
    <dbReference type="CTD" id="20329604"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="339" mass="37324" checksum="650F03DB15716C53" modified="2014-10-01" version="1">MSVNEKPVRETKGFMRKLCVIPGRLVGKVAIVTGANTGIGKMTAAELARRGCQVIMACRNKERAESAKKWILDTYGVGNPDHLKTNLADPCLTSSLTAVTPDQLQIELLDLASLKSVREFATRIGQRREHLNYLINNAGLAMEDHCTTEDGYEHTIAVNHLGPFLLTELLMPLLRKGVPSRIIMVSSIVHRYGELRKPDLQTAPEEYGLLSAYAQSKLANLIHARELAKRLSGSGVIPVSLHPGAVRTELFRDARTMKSRMIHYLILPFTTTPWMGCQTTLYTVLTPNLTPGAYYDNCTETSPASNALNDADGEWLWNKSCELVGLTQGTATDSKCENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ20</accession>
    <name>A0A074YZ20_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597101">
        <property type="protein sequence ID" value="KER20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176212.1">
        <property type="nucleotide sequence ID" value="XM_009177948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ20"/>
    <dbReference type="STRING" id="6198.A0A074YZ20"/>
    <dbReference type="GeneID" id="20325491"/>
    <dbReference type="KEGG" id="ovi:T265_11323"/>
    <dbReference type="CTD" id="20325491"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="224" mass="24811" checksum="C0F53011F74CE91E" modified="2014-10-01" version="1">MEAVGHAGTCLGIVASDGIVLAAERRFINNLLDETAFSEKIYKINDDIACAVAGITADATVLINEMRLIAQRYLLSYQEPMPVEQLVYHICDLQHGYTMYGGRRPFGVSMLFIGWDDRHGYQLFQTDPSGNCLGWKAACIGSNSAAASSILEQDYDPQCTTEQAIKLCLKSLHKTMTMSKLTSDKVELGVLQRRGGKTYVRLINQSEVDAVIRQIETEEPPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZC8</accession>
    <name>A0A074YZC8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597087">
        <property type="protein sequence ID" value="KER20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176110.1">
        <property type="nucleotide sequence ID" value="XM_009177846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZC8"/>
    <dbReference type="GeneID" id="20325413"/>
    <dbReference type="KEGG" id="ovi:T265_11245"/>
    <dbReference type="CTD" id="20325413"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="961" mass="100477" checksum="04194E7A747F1633" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZH9</accession>
    <name>A0A074YZH9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599161">
        <property type="protein sequence ID" value="KER18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177636.1">
        <property type="nucleotide sequence ID" value="XM_009179372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZH9"/>
    <dbReference type="STRING" id="6198.A0A074YZH9"/>
    <dbReference type="GeneID" id="20330102"/>
    <dbReference type="KEGG" id="ovi:T265_15937"/>
    <dbReference type="CTD" id="20330102"/>
    <dbReference type="OrthoDB" id="6259035at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="137" mass="15622" checksum="94CD24D474D5DA3D" modified="2014-10-01" version="1" fragment="single">SSVDTSSPFVPSTCAYRVFRNDRIVRSFSQVISAEGDVRGMCITPDWALNPLRLNAVHRGRRQQTFSARLEDEDNLLRRVRSIEGDDYKPPHRKQFELEDSSSVRATRSIISGVRKRQQEIIKCEQETVNLGTPLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z082</accession>
    <name>A0A074Z082_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597580">
        <property type="protein sequence ID" value="KER18882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177371.1">
        <property type="nucleotide sequence ID" value="XM_009179107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z082"/>
    <dbReference type="STRING" id="6198.A0A074Z082"/>
    <dbReference type="GeneID" id="20329937"/>
    <dbReference type="KEGG" id="ovi:T265_15772"/>
    <dbReference type="CTD" id="20329937"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="51" mass="6286" checksum="BFDDB2AE2B58BF84" modified="2014-10-01" version="1" fragment="single">MHCRENQKRALLELIAQAIVERSLEEERMRQGKIRKTLEEICKLHRVRRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0G7</accession>
    <name>A0A074Z0G7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597424">
        <property type="protein sequence ID" value="KER18967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177290.1">
        <property type="nucleotide sequence ID" value="XM_009179026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0G7"/>
    <dbReference type="GeneID" id="20326246"/>
    <dbReference type="KEGG" id="ovi:T265_12078"/>
    <dbReference type="CTD" id="20326246"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14762" checksum="10DCC0FC9E1D7B54" modified="2014-10-01" version="1">MAEEYCSTSIPMVVDSIACTSVRIKHLHHASRQWLTVLEITHSRGNTTWCINAMDSVSKRIKSKLMIHEYGESGVAVFEKAACNMKLLLPAPPSKEYRTELTWDSSYIQDGPPNPENNTPIELLKTSQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Z1</accession>
    <name>A0A074Z0Z1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597030">
        <property type="protein sequence ID" value="KER20686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175560.1">
        <property type="nucleotide sequence ID" value="XM_009177296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Z1"/>
    <dbReference type="STRING" id="6198.A0A074Z0Z1"/>
    <dbReference type="GeneID" id="20324985"/>
    <dbReference type="KEGG" id="ovi:T265_10817"/>
    <dbReference type="CTD" id="20324985"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="291"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="585" mass="65625" checksum="AD4BF5C6FBA43239" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1X5</accession>
    <name>A0A074Z1X5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597194">
        <property type="protein sequence ID" value="KER19497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176766.1">
        <property type="nucleotide sequence ID" value="XM_009178502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20329691"/>
    <dbReference type="KEGG" id="ovi:T265_15526"/>
    <dbReference type="CTD" id="20329691"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15981" checksum="B095E0ACAB3BE7BC" modified="2014-10-01" version="1" fragment="single">KHQLNSYRLLDRGAKLSXSYASCFQKLNIHLLLERVFLHSLLLKYKQMLQSDSTNPVRDHTFQETRSGFTRKHTTRKPPSVISPAHHHLKIALKTPSEQLHTIGQKLNIRLLFERVLVNFPGYSMTVAQVQANATSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Y6</accession>
    <name>A0A074Z2Y6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596968">
        <property type="protein sequence ID" value="KER21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174830.1">
        <property type="nucleotide sequence ID" value="XM_009176566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Y6"/>
    <dbReference type="GeneID" id="20324416"/>
    <dbReference type="KEGG" id="ovi:T265_10248"/>
    <dbReference type="CTD" id="20324416"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13021" checksum="E193E2F2DF84956A" modified="2014-10-01" version="1">MTINGDGMRSHANVTFQGYMQRNLPPEQCHWEDPPGLLKELRVLADADSPCFSKQIVTSSATAAASWNLRPALPSESDDSLICESFLSPFDIHPLSDVDFSICNLATSAFSVCASAASDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4B1</accession>
    <name>A0A074Z4B1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175891.1">
        <property type="nucleotide sequence ID" value="XM_009177627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4B1"/>
    <dbReference type="STRING" id="6198.A0A074Z4B1"/>
    <dbReference type="GeneID" id="20325243"/>
    <dbReference type="KEGG" id="ovi:T265_11075"/>
    <dbReference type="CTD" id="20325243"/>
    <dbReference type="OrthoDB" id="10030815at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="380"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="590" mass="65534" checksum="1464F4B15DCA7131" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4E4</accession>
    <name>A0A074Z4E4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596931">
        <property type="protein sequence ID" value="KER21933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174329.1">
        <property type="nucleotide sequence ID" value="XM_009176065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4E4"/>
    <dbReference type="GeneID" id="20329147"/>
    <dbReference type="KEGG" id="ovi:T265_14981"/>
    <dbReference type="CTD" id="20329147"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="32717" checksum="A6D8EEC311DF27E7" modified="2014-10-01" version="1" fragment="single">MYMEDGPEQTAKHMKYLNSSLICYIRNNGWVDLVAYVLPVSTSTFHWFTQTCTLDEVGMSTVPAQDNRIILVYRLECCDPGNFADNPRPPHVVSGDLVPPSTRLHVPLSPVTQKHILIDPGNFADNCTPPHVVSGDLVPPSTQNHQHQRQHQQERQQYPNYDMTEECYRPPTKTILSETDQRLLLTVDPGPDDVTISPELLPVLFCLHMRLQIFHTCFICAEIPPGKFPLFEMYYLMSPKKDEGGCGLSMDFLLCIFTSLGPLNGFFFLGSFTDSVHMCSSKGAGTIGMGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5J0</accession>
    <name>A0A074Z5J0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596904">
        <property type="protein sequence ID" value="KER22343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173906.1">
        <property type="nucleotide sequence ID" value="XM_009175642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5J0"/>
    <dbReference type="GeneID" id="20323709"/>
    <dbReference type="KEGG" id="ovi:T265_09540"/>
    <dbReference type="CTD" id="20323709"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6511" checksum="95903E1B335FC259" modified="2014-10-01" version="1">MLCCATKPKQDDSGISVGGDLEDLEENGPTPEKLKQSAIFMAVVKTLHNPHYRENAPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6W1</accession>
    <name>A0A074Z6W1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597412">
        <property type="protein sequence ID" value="KER18975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177277.1">
        <property type="nucleotide sequence ID" value="XM_009179013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6W1"/>
    <dbReference type="STRING" id="6198.A0A074Z6W1"/>
    <dbReference type="GeneID" id="20326240"/>
    <dbReference type="KEGG" id="ovi:T265_12072"/>
    <dbReference type="CTD" id="20326240"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF141">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER18975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="629" mass="69246" checksum="3436E5DBC0FD0B7C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z848</accession>
    <name>A0A074Z848_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596857">
        <property type="protein sequence ID" value="KER23278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172983.1">
        <property type="nucleotide sequence ID" value="XM_009174719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z848"/>
    <dbReference type="STRING" id="6198.A0A074Z848"/>
    <dbReference type="MEROPS" id="C01.130"/>
    <dbReference type="GeneID" id="20322991"/>
    <dbReference type="KEGG" id="ovi:T265_08812"/>
    <dbReference type="CTD" id="20322991"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="23871" checksum="A0041B33B9A73B64" modified="2014-10-01" version="1">MRFDEPIVNEDPTPQEDVTADNSNFDWRDHGAVGPVLDQGDCGSCWAFSVIGNVEGQWFRKTGDLLGLSEQTYSAIEEMGGLELRSDYPYTGKDGICYMDQSKFVAYVNGSTRLPWCEKTQAKSLKEIGPLSSGLNAILLQFYRRGIILPIPLLCNPHNVNHAVLTVGYGTEFGLPYWIVKNSWGVKFGEEGYFRIFRGAGTCGINRIVSTAIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8C4</accession>
    <name>A0A074Z8C4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DENN domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAB6IP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172814.1">
        <property type="nucleotide sequence ID" value="XM_009174550.1"/>
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    <dbReference type="GeneID" id="20322858"/>
    <dbReference type="KEGG" id="ovi:T265_08679"/>
    <dbReference type="CTD" id="20322858"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
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        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047278">
        <property type="entry name" value="DEN5A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
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    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46070:SF1">
        <property type="entry name" value="PINSTRIPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UDENN" evidence="8">
        <location>
            <begin position="1"/>
            <end position="593"/>
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    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="896"/>
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    </feature>
    <feature type="domain" description="PLAT" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="1383"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="945"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1326"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1469"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1656" mass="182115" checksum="10170D062A4F73B7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8R2</accession>
    <name>A0A074Z8R2_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UTP25 small subunit processor component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09840</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009176026.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="80"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="7">
        <location>
            <begin position="471"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER21972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="633" mass="71928" checksum="1B08D7A28676A7F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W6</accession>
    <name>A0A074Z8W6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596924">
        <property type="protein sequence ID" value="KER22032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174222.1">
        <property type="nucleotide sequence ID" value="XM_009175958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8W6"/>
    <dbReference type="STRING" id="6198.A0A074Z8W6"/>
    <dbReference type="GeneID" id="20323952"/>
    <dbReference type="KEGG" id="ovi:T265_09784"/>
    <dbReference type="CTD" id="20323952"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="20171" checksum="36FCCC99D81EBA86" modified="2014-10-01" version="1">MQSIDNKTNKLISCSTLSVPNCHATTRRKHEGWETARLSEPRQGKSRGRGRVRTTNLPDRTNKLISCSTLSVPNCHATTRRKHEGWETARLSEPRQGKSRGRGRVRTTDLPDDNITKYLLCGMDIELGLNMANVHIFRAESFESNKVNNNQCKRKPSFTASMEIHKYQEGQLPEINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9B7</accession>
    <name>A0A074Z9B7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172582.1">
        <property type="nucleotide sequence ID" value="XM_009174318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9B7"/>
    <dbReference type="STRING" id="6198.A0A074Z9B7"/>
    <dbReference type="GeneID" id="20328753"/>
    <dbReference type="KEGG" id="ovi:T265_14587"/>
    <dbReference type="CTD" id="20328753"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="550" mass="61659" checksum="404D3EA7C5441982" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9L8</accession>
    <name>A0A074Z9L8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596909">
        <property type="protein sequence ID" value="KER22257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174004.1">
        <property type="nucleotide sequence ID" value="XM_009175740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9L8"/>
    <dbReference type="GeneID" id="20323787"/>
    <dbReference type="KEGG" id="ovi:T265_09619"/>
    <dbReference type="CTD" id="20323787"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21472" checksum="BBDB2E204D43B5D9" modified="2014-10-01" version="1">MRSHLPHLTRSLVNETVAATTTVRRCQPPTQTAVVYNYITSGFFMKETTHEVAENSSTAHDRFRPSWGSSVRRSPLVSINIMFYLNPNLIVLSHQFYIPCLRHVPPSLSLWPANETARETWPLLAEDIKRLSVFECRCLRSIARVCIAEIRRMVFGRNNSPTIDELVTLHSLRWLDNVLRMPVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9R6</accession>
    <name>A0A074Z9R6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172284.1">
        <property type="nucleotide sequence ID" value="XM_009174020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9R6"/>
    <dbReference type="GeneID" id="20322451"/>
    <dbReference type="KEGG" id="ovi:T265_08272"/>
    <dbReference type="CTD" id="20322451"/>
    <dbReference type="OrthoDB" id="10059837at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12656" checksum="534CC5DE46D9A07A" modified="2014-10-01" version="1">MLLQGPDTTDDFLGVLLYFRIDLPEVSADAEEVFMQIHDQGALRFLWFSQNESIIIVWCQCLSPLMQSFVHETTEVLSKWGFHLHEWVDNIRDVLQRLPPSGRMMFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA99</accession>
    <name>A0A074ZA99_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase Rbp10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596894">
        <property type="protein sequence ID" value="KER22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173727.1">
        <property type="nucleotide sequence ID" value="XM_009175463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA99"/>
    <dbReference type="STRING" id="6198.A0A074ZA99"/>
    <dbReference type="GeneID" id="20323581"/>
    <dbReference type="KEGG" id="ovi:T265_09412"/>
    <dbReference type="CTD" id="20323581"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7592" checksum="BEA2978CFAABDC4D" modified="2014-10-01" version="1">MDSAKRGGETPGAGTTVPQFTKTVSYICGECRAENEIRPRELVRCLECGHRVLYKKRSKRMSVFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD28</accession>
    <name>A0A074ZD28_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171151.1">
        <property type="nucleotide sequence ID" value="XM_009172887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD28"/>
    <dbReference type="GeneID" id="20321562"/>
    <dbReference type="KEGG" id="ovi:T265_07383"/>
    <dbReference type="CTD" id="20321562"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12929" checksum="886DCF244BF194DA" modified="2014-10-01" version="1">MTTEEANGTLNRRSTDEVPTKHKLPSVHQSQCSWPSCHDLKKNAAICIVEYKGRINRPSAQTFKLLPEVAAIVYFGWRIDRCVYVKVVTKEQCGSTTEKHSTPQTKLRGEAGRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDG0</accession>
    <name>A0A074ZDG0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170930.1">
        <property type="nucleotide sequence ID" value="XM_009172666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDG0"/>
    <dbReference type="STRING" id="6198.A0A074ZDG0"/>
    <dbReference type="GeneID" id="20321389"/>
    <dbReference type="KEGG" id="ovi:T265_07210"/>
    <dbReference type="CTD" id="20321389"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12395">
        <property type="entry name" value="RRM2_RBM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034221">
        <property type="entry name" value="RBM34_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="485" mass="54215" checksum="AFC45F4E661B0849" modified="2014-10-01" version="1">MARVVYDAEAALIARFGTNYHRMAISGEESPVTRNPPSGIHARKKRCGHPLGSMHKQHHSHAPRISRADVTPELEQSSICESPPKASAKRSKNKRSDTNHKVDKAHAKRAKQDASFDDLLDVSSRSGTSEGEEEDIPNVVRDRAAQRNNRHLRNERLKRTLFVGNLPPGLKKTELRRLFDTVIKQDSASVQSNCRVESVRFRGVVPVTGGTGKLARKRAVIQGEFSAGVSQNMIAYVVLTSTAGIPAGLSLNGHWLQTKPISTDTPTDYQSSGKHIRVDRALRQRPVEQFKQSVFLGNLPFDVQEEEVRTAMSKFGPIANVRLIRDKETGAVKGFGFVQYTDPAAISLAIRSSESVSIRGRPIRVQEWKADTKSGRAEWKPKPPKAVLLHSSPRNPIKRTSEKHSADADSSGKKRKLLQRLRHAGQVKGVTLPSNLRGEQRERYLQKRLIKKRKRQVRRQQQQAQSKPVSVKKSGKVTKKTRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE31</accession>
    <name>A0A074ZE31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium / potassium ATPase beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172356.1">
        <property type="nucleotide sequence ID" value="XM_009174092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE31"/>
    <dbReference type="STRING" id="6198.A0A074ZE31"/>
    <dbReference type="GeneID" id="20322505"/>
    <dbReference type="KEGG" id="ovi:T265_08326"/>
    <dbReference type="CTD" id="20322505"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31337" checksum="6CB0F9A465426E05" modified="2014-10-01" version="1">MKQEHQQSRLRRIAKFFYSKEDGTVLGRTPKSWGLIFAFYLVAYAFLAGFFVGMISVFMYGYVSNEIPTLTGKQSLLSLSPGVAFAPRVTTTTAFLQFTTFPSSINAPYVEGVRRLLSRYEASNLTTVCPDGAAAITFPEQPCQFPLTSLGPCAEPEASLKAGLPCIYLRLNRVYGWLPDLANDTVFPEAAIGCYGQNDIAKFQLGDPEYFPQLVTPSGEKYAKIPSTYFPFIGQAGYQAPLAAVRFPNIMKNTVVLVECKVYGLAGVDSEVMFEIAVDGRKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF11</accession>
    <name>A0A074ZF11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170370.1">
        <property type="nucleotide sequence ID" value="XM_009172106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF11"/>
    <dbReference type="GeneID" id="20328281"/>
    <dbReference type="KEGG" id="ovi:T265_14115"/>
    <dbReference type="CTD" id="20328281"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15593" checksum="EE9DA62B1B5A82D6" modified="2014-10-01" version="1" fragment="single">MPPEGCTGTGILPGCPSLDRGNREPEVGFELWTLRSVNSRLNPLVIPPLSIVKIWKNLCVPEQTISNTFKMHVSISILAVLGQPGSIPALVLPSGGMAARHRKCATAERCTIYYQISNIVPTETRDGLRAAFSTENNITDEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGY6</accession>
    <name>A0A074ZGY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171307.1">
        <property type="nucleotide sequence ID" value="XM_009173043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGY6"/>
    <dbReference type="STRING" id="6198.A0A074ZGY6"/>
    <dbReference type="GeneID" id="20321685"/>
    <dbReference type="KEGG" id="ovi:T265_07506"/>
    <dbReference type="CTD" id="20321685"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45226" checksum="B2C26B9C03E88C7C" modified="2014-10-01" version="1">MLRFVGSPVTVVKVAAIGERIRSSRQLVLTETEVDRESQAVTGPRIISLSLKDHGMSGKLSGYICLVTGASRGLGKAIAVALGEAGATVYITGRTVDCSSNGSEHYTSGLKETARLIEAAGGKAIAVAVDHSDDSQVAGLFARIRREQCGRLDVLVNNAFSASSYLVAEASLDTVYWEPMTTLRSPSEEWDLINRVGLRNAYTCCVLATRMMVECRSNMNAGSCHTSTLENNVNEKACLKSVMSNPLPTGVIVNISSYGGMERIFNVAFCAGKSALDRMSMEMARDLKKRGVDVAVLSLLPGLVKTETLVAALESGQVPQLLSTAMNAGLGLPPEVPGRVVANLVGQSRAALINQSGRCLFGEELARQFAIKLPNRRYPLSRRAVKTILLMAGWTRLACLVPSFVKIPRWALLIWCSNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHY9</accession>
    <name>A0A074ZHY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173332.1">
        <property type="nucleotide sequence ID" value="XM_009175068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHY9"/>
    <dbReference type="STRING" id="6198.A0A074ZHY9"/>
    <dbReference type="GeneID" id="20323262"/>
    <dbReference type="KEGG" id="ovi:T265_09083"/>
    <dbReference type="CTD" id="20323262"/>
    <dbReference type="OrthoDB" id="6260190at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="18686" checksum="B562FAB9C8CC67DD" modified="2014-10-01" version="1">MPEHLNDSDTPVEHPLVANTIIKQAETIENFSDDQRPEVEQSGSPEEADDSSEIIPLKAQTGSEERHVRFFPLSTPTGFWRKVPKIVFFIVPILLVTLGVLAFAVYASVTSAHCSSPTETDEQPAGSTKNFPSPTFGLDELFITGSCCNPVNLVNRIHSGFLAAFAGVTTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI59</accession>
    <name>A0A074ZI59_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596870">
        <property type="protein sequence ID" value="KER22995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173264.1">
        <property type="nucleotide sequence ID" value="XM_009175000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI59"/>
    <dbReference type="GeneID" id="20323215"/>
    <dbReference type="KEGG" id="ovi:T265_09036"/>
    <dbReference type="CTD" id="20323215"/>
    <dbReference type="OrthoDB" id="10628666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="37512" checksum="ACDBE0CCFFFC9363" modified="2014-10-01" version="1">MVLQHHVRKGAAHSPSNCYDRKSGKYSISVEMDGSCGLHRSETGMEASFYQIEVHCLNPEGRKGLMLNKTTSQNKPQDDEATLGGMHFAPDESSVWPNMSCEHDDIHQHKVKGVVTQGGPVSRENSITLPSCLTGQKIKGSFQIKEHKHCWSLEAVSLFRNLSEGEDMIDASSRRTEPKLAFTDLSIAVSGQPSKDKARSTFGVTANRLTPRWFSHSVRVPFLKMGIMVNITHSAGTFSLIHKNGGVSSVLELINNPEALLYATSVATTVEIFHVHEENEEKIRHEAHYTVGTFLIDGHVVEVRCVSSAVPGIVWDRRCERGRRGTKRHEELSKSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIZ8</accession>
    <name>A0A074ZIZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170486.1">
        <property type="nucleotide sequence ID" value="XM_009172222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZIZ8"/>
    <dbReference type="GeneID" id="20321019"/>
    <dbReference type="KEGG" id="ovi:T265_06840"/>
    <dbReference type="CTD" id="20321019"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="23682" checksum="ECDD82141EAE822B" modified="2014-10-01" version="1">MCSFPTAEFPLAFDGEAVLTIGQEYAIGAHLHFPDSDNNRLSGMSILTLELVDNAQNTIKMFRKPFSIPYRSKMVRLAKLLLLLPLYILNLIDEEIYVFLPLASGFQHTQDSPVSMGRVTIESLRLEWSFATIAFNARLTGIQGFLYYWPWVSSAFLAVSMFSLLNILYLLLGYYRYAQPTNASPHSIVPSSNIHAVPPKTPSDSEVVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJJ5</accession>
    <name>A0A074ZJJ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170311.1">
        <property type="nucleotide sequence ID" value="XM_009172047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJJ5"/>
    <dbReference type="STRING" id="6198.A0A074ZJJ5"/>
    <dbReference type="GeneID" id="20320892"/>
    <dbReference type="KEGG" id="ovi:T265_06713"/>
    <dbReference type="CTD" id="20320892"/>
    <dbReference type="OrthoDB" id="6256369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="623" mass="69261" checksum="C2BA5862BE700EE6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJN5</accession>
    <name>A0A074ZJN5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168717.1">
        <property type="nucleotide sequence ID" value="XM_009170453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJN5"/>
    <dbReference type="GeneID" id="20319628"/>
    <dbReference type="KEGG" id="ovi:T265_05446"/>
    <dbReference type="CTD" id="20319628"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="21781" checksum="42962581EBDDBCC3" modified="2014-10-01" version="1">MEWAPLMDIISCMKAFGEFPVYDTFLIRLLRTLRQPTVLSFFGLTRRDAGVGGLKGGNSRERLTLENHFPQRAYYIIFTNRTLHLPSPESGSNSNSVLRLNAQLCVLPTHTQTLHYLVFEGFVCAVVLVAFLASVMDSDLDDIQWSCGRIGEVGQIAMNAANIAASIFCHASSTCSLPPKYWFAVESCSAISDRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKJ5</accession>
    <name>A0A074ZKJ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="22">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">T265_08342</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41496"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78263"/>
            <dbReference type="ChEBI" id="CHEBI:78264"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41497"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41604"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78342"/>
            <dbReference type="ChEBI" id="CHEBI:78343"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41600"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78340"/>
            <dbReference type="ChEBI" id="CHEBI:78341"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41601"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41488"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78261"/>
            <dbReference type="ChEBI" id="CHEBI:78262"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41484"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
            <dbReference type="ChEBI" id="CHEBI:75029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41492"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78265"/>
            <dbReference type="ChEBI" id="CHEBI:78266"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41493"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41500"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78268"/>
            <dbReference type="ChEBI" id="CHEBI:78269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41501"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:40795"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:75038"/>
            <dbReference type="ChEBI" id="CHEBI:78260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40796"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 22">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Endoplasmic reticulum membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="22"/>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172374.1">
        <property type="nucleotide sequence ID" value="XM_009174110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKJ5"/>
    <dbReference type="STRING" id="6198.A0A074ZKJ5"/>
    <dbReference type="GeneID" id="20322521"/>
    <dbReference type="KEGG" id="ovi:T265_08342"/>
    <dbReference type="CTD" id="20322521"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 22" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 22" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 22" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KER23880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="71499" checksum="E01E73840C691C5F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMU0</accession>
    <name>A0A074ZMU0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171605.1">
        <property type="nucleotide sequence ID" value="XM_009173341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMU0"/>
    <dbReference type="GeneID" id="20321921"/>
    <dbReference type="KEGG" id="ovi:T265_07742"/>
    <dbReference type="CTD" id="20321921"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="9778" checksum="0A34CA9FBFEF6E66" modified="2014-10-01" version="1">MMKGNKQENLLQSEFSLAVGVQALSSVASVGGEFRGFVYHGAFVGVDETEDGRSMIVAKPEEDPRKFTEESPVSSSQMAGALKSPTIGYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMZ0</accession>
    <name>A0A074ZMZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167454.1">
        <property type="nucleotide sequence ID" value="XM_009169190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMZ0"/>
    <dbReference type="GeneID" id="20318623"/>
    <dbReference type="KEGG" id="ovi:T265_04441"/>
    <dbReference type="CTD" id="20318623"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="277" mass="29758" checksum="43DC797ED24CB536" modified="2014-10-01" version="1">MSIHIFHNLVQFNCSTLSVPGWHATRRRHDGWDTASSIVAPFRCLAGMPHEGGTTAGILPGRPSLNKGSREAEVGFEPWIIQSVNLRSNQFGSSRPSPAVSHRFIAESQIAYLKDCEIPKQASVGSEGLTDAGLEALESVIESVSSSVSLAPRLRRGDRGLSMLILSDFKGYGLESSFRFFVVSNFSEYVSSTDLLRFLPTEELPSSDELRILDKIGEACAGITGDMLEDAGVDSHCEVSGCPGGNGVAEMEVVSNVIGVLLGVRLVLSVMESSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNM9</accession>
    <name>A0A074ZNM9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 5">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 5"/>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167258.1">
        <property type="nucleotide sequence ID" value="XM_009168994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNM9"/>
    <dbReference type="STRING" id="6198.A0A074ZNM9"/>
    <dbReference type="GeneID" id="20318477"/>
    <dbReference type="KEGG" id="ovi:T265_04295"/>
    <dbReference type="CTD" id="20318477"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="17848" checksum="3E4B8743EF44FCAF" modified="2014-10-01" version="1">MRAVIQRVKEASVTVDGSVVSEIGRGILVLIGISAKDSKTDTAYIVRKLLNLRIFPNEDGSRRWDKSVRDLNLELLCVSQFTLYTELKGNKLDFHRAMDPSLSQLVYSELIAQLREAYQEDRVKDGVFGALMDVQLVNDGPVTICLDSNTVKSDKDASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNP2</accession>
    <name>A0A074ZNP2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168812.1">
        <property type="nucleotide sequence ID" value="XM_009170548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNP2"/>
    <dbReference type="GeneID" id="20319696"/>
    <dbReference type="KEGG" id="ovi:T265_05514"/>
    <dbReference type="CTD" id="20319696"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13507" checksum="D9EE6D25ACA1CD5E" modified="2014-10-01" version="1">MVFGRINSPSIDELITLHRLRWLGHVLSMPVDRLPRKALFAQPRGGWNRARGGQTMTWQRKCYFHSANCMNKSLFSSPIWVQVEHKVDGNWGDCAYLMSPKKGETGRGLSNSFQQPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNU9</accession>
    <name>A0A074ZNU9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167484.1">
        <property type="nucleotide sequence ID" value="XM_009169220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNU9"/>
    <dbReference type="GeneID" id="20318653"/>
    <dbReference type="KEGG" id="ovi:T265_04471"/>
    <dbReference type="CTD" id="20318653"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="246" mass="26949" checksum="C70D1A4CEED4BD2C" modified="2014-10-01" version="1">MCCTQTASCFSWHDIRDIAGQWSLKQCNNHPSIAPFRCPSAMPPEGYTRVGILPGSPSLDRGSRGAKVGFEPRTFRSCHYPTTGLIPGSQVNRSTVAPFRCLTAMPHEGGTRAGILPDCPSLDRGSQEAKVGFEPRTFRSVNSRSNHLVHLAPSQVSETVAVHPVNAFILCYKVIRYSPLSFPVSTELSKKDLHQVEGPRSQSTGYISSRRPCDTPKKMTVDLFAELSNWLANVSSPVEETSSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP87</accession>
    <name>A0A074ZP87_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein chibby homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167325.1">
        <property type="nucleotide sequence ID" value="XM_009169061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP87"/>
    <dbReference type="STRING" id="6198.A0A074ZP87"/>
    <dbReference type="GeneID" id="20327647"/>
    <dbReference type="KEGG" id="ovi:T265_13480"/>
    <dbReference type="CTD" id="20327647"/>
    <dbReference type="OrthoDB" id="2145765at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07429">
        <property type="entry name" value="Cby_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028118">
        <property type="entry name" value="Chibby_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21533">
        <property type="entry name" value="LEUCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21533:SF19">
        <property type="entry name" value="LEUCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14645">
        <property type="entry name" value="Chibby"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15578" checksum="CF5751CF13AA7ED5" modified="2014-10-01" version="1">MPLFAKRFSVPKFPSRKAASMTNLSQLDSVTRSQEFGLDFGPIRTRLSGRNLVFRDGNWIVEGGDTQNAAKLDRESFRIKKENHQLVEENNLLKLKIDILLDMLAETTAEVHLQGNEIENLRAMLNKKPQTNPIQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX8</accession>
    <name>A0A074ZPX8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166809.1">
        <property type="nucleotide sequence ID" value="XM_009168545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPX8"/>
    <dbReference type="STRING" id="6198.A0A074ZPX8"/>
    <dbReference type="GeneID" id="20318131"/>
    <dbReference type="KEGG" id="ovi:T265_03945"/>
    <dbReference type="CTD" id="20318131"/>
    <dbReference type="OrthoDB" id="6234367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="109"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="578" mass="64582" checksum="5C318D08E1EE6DEC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQK0</accession>
    <name>A0A074ZQK0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166582.1">
        <property type="nucleotide sequence ID" value="XM_009168318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQK0"/>
    <dbReference type="GeneID" id="20317952"/>
    <dbReference type="KEGG" id="ovi:T265_03765"/>
    <dbReference type="CTD" id="20317952"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="17355" checksum="54EA793A693E3D19" modified="2014-10-01" version="1">MAARHRKDVTAERFFFNLTCMTQWLECGFTDRKVCGSNPTFAFGLPLSRLGQPDLVLPWGSMVARHRRTPQLNAFFITVIITTNSITSVFNTDSLLPYTNVKLITKIFDGLNIPPPKRQINLKVKKKRPSGATCYVVPPKRDQPCQGGLHLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSF4</accession>
    <name>A0A074ZSF4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165914.1">
        <property type="nucleotide sequence ID" value="XM_009167650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSF4"/>
    <dbReference type="GeneID" id="20327352"/>
    <dbReference type="KEGG" id="ovi:T265_13184"/>
    <dbReference type="CTD" id="20327352"/>
    <dbReference type="OrthoDB" id="674273at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="17316" checksum="74483D7828BB1AA4" modified="2014-10-01" version="1" fragment="single">PVTLWFEEHKLYTFAKVTDTNIKGTGHYTQVIWETTTNLGCHQHLCNPLIDGTGNNIGTMYFSLVVDQMAVDLFAELGNWLANVSSSYEETSSVRSWLSIILVDMVSTQHHASETLSPEKFRDLHNAFRKMILNGSVPDRRKCQFWFWTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSY5</accession>
    <name>A0A074ZSY5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ion channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_03018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165671.1">
        <property type="nucleotide sequence ID" value="XM_009167407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSY5"/>
    <dbReference type="STRING" id="6198.A0A074ZSY5"/>
    <dbReference type="GeneID" id="20317205"/>
    <dbReference type="KEGG" id="ovi:T265_03018"/>
    <dbReference type="CTD" id="20317205"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="385"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="484"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="13">
        <location>
            <begin position="675"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="88192" checksum="9FE44F8D26CC96F2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT90</accession>
    <name>A0A074ZT90_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nodal modulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_13966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169660.1">
        <property type="nucleotide sequence ID" value="XM_009171396.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZT90"/>
    <dbReference type="GeneID" id="20328133"/>
    <dbReference type="KEGG" id="ovi:T265_13966"/>
    <dbReference type="CTD" id="20328133"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055490">
        <property type="entry name" value="DUF7062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056191">
        <property type="entry name" value="NOMO_12th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056189">
        <property type="entry name" value="NOMO_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056188">
        <property type="entry name" value="NOMO_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23201">
        <property type="entry name" value="DUF7062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23192">
        <property type="entry name" value="NOMO_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23193">
        <property type="entry name" value="NOMO_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23196">
        <property type="entry name" value="NOMO_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705344" description="Nodal modulator 2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="4">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="5">
        <location>
            <begin position="126"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO third transthyretin-like" evidence="7">
        <location>
            <begin position="219"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="8">
        <location>
            <begin position="423"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO sixth transthyretin-like" evidence="9">
        <location>
            <begin position="510"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7062" evidence="10">
        <location>
            <begin position="636"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO C-terminal transthyretin-like" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1347" mass="148313" checksum="5B976751C9C7FE3F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTJ5</accession>
    <name>A0A074ZTJ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="6">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="6"/>
    <dbReference type="EMBL" id="KL599792">
        <property type="protein sequence ID" value="KER18564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177689.1">
        <property type="nucleotide sequence ID" value="XM_009179425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTJ5"/>
    <dbReference type="STRING" id="6198.A0A074ZTJ5"/>
    <dbReference type="GeneID" id="20330141"/>
    <dbReference type="KEGG" id="ovi:T265_15976"/>
    <dbReference type="CTD" id="20330141"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER18564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="19487" checksum="EF711D0EBAFDB5C0" modified="2014-10-01" version="1" fragment="single">MRVTATLWAFSGKYAEKFVQYGAYCPTPLSLKKLISFGRVGSAAKSAAFLRDELAVRIANIMQEIHLLPEALIRTPSASIVERWYEQSFCHLVDYEGMEWNEKSLEKFNHTLAEIRHRHTATVETMAQGVMEMEAQNKADPITNNHIQYFLDRFFMMRISLRMLLNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUA5</accession>
    <name>A0A074ZUA5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597977">
        <property type="protein sequence ID" value="KER18784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177469.1">
        <property type="nucleotide sequence ID" value="XM_009179205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUA5"/>
    <dbReference type="GeneID" id="20329994"/>
    <dbReference type="KEGG" id="ovi:T265_15829"/>
    <dbReference type="CTD" id="20329994"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6514" checksum="B2E31EBABD502812" modified="2014-10-01" version="1" fragment="single">MSCSRNNAYFPGDLHPTNLCLGEQSDGYAAYEVKLFHGQRGSLLAPVSKVLSGIKFRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUK6</accession>
    <name>A0A074ZUK6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_02840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165448.1">
        <property type="nucleotide sequence ID" value="XM_009167184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUK6"/>
    <dbReference type="STRING" id="6198.A0A074ZUK6"/>
    <dbReference type="GeneID" id="20317028"/>
    <dbReference type="KEGG" id="ovi:T265_02840"/>
    <dbReference type="CTD" id="20317028"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="104"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="374"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="880"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129060" checksum="33D5A4DB347E1EA5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVZ4</accession>
    <name>A0A074ZVZ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166213.1">
        <property type="nucleotide sequence ID" value="XM_009167949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVZ4"/>
    <dbReference type="STRING" id="6198.A0A074ZVZ4"/>
    <dbReference type="GeneID" id="20327415"/>
    <dbReference type="KEGG" id="ovi:T265_13248"/>
    <dbReference type="CTD" id="20327415"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="19134" checksum="560A68791D78564B" modified="2014-10-01" version="1" fragment="single">ETIKLFSQRKLLTRLLKIHRQPTTGFALLGAHQVGVATEFPQPYVLLEPTMVVGCRNVFSKLAWATWQNPSLRAYYYDLITKTTITTNTGFRPSHVSVGMIFEISRYIFIRETTPESAENSSTAHDRFRPYSWGSSGRRSPRVSVDLIIYMNPNWTVFEKYTHLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW80</accession>
    <name>A0A074ZW80_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597203">
        <property type="protein sequence ID" value="KER19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176795.1">
        <property type="nucleotide sequence ID" value="XM_009178531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW80"/>
    <dbReference type="STRING" id="6198.A0A074ZW80"/>
    <dbReference type="GeneID" id="20325944"/>
    <dbReference type="KEGG" id="ovi:T265_11776"/>
    <dbReference type="CTD" id="20325944"/>
    <dbReference type="OrthoDB" id="10375637at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="17177" checksum="1D3CBD7996232D6B" modified="2014-10-01" version="1">MISLAWNLIRTSHQLAGFRNLSMLPSVGCQLVERWQAGFVSILASAVDMDRLTQLQRSGQAGRAGGTMAAGQGRASLLNFGSQVAAFYFVIWTILDEIMDKLERLTYHCRLLGVTFLKKKRESSASYSTIAWLSESIEPHLGLAEFLIHKLMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWA4</accession>
    <name>A0A074ZWA4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWA4"/>
    <dbReference type="GeneID" id="20325926"/>
    <dbReference type="KEGG" id="ovi:T265_11758"/>
    <dbReference type="CTD" id="20325926"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8914" checksum="B202610EE2AD7DD6" modified="2014-10-01" version="1">MKFTTIFDGTFIHATVVPYLKKPVYKIYLLMYNEVRDNPLNRALMMSPRMVTKRLQANCQARRTNQQPPDQQPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWC1</accession>
    <name>A0A074ZWC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597192">
        <property type="protein sequence ID" value="KER19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176746.1">
        <property type="nucleotide sequence ID" value="XM_009178482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWC1"/>
    <dbReference type="GeneID" id="20325907"/>
    <dbReference type="KEGG" id="ovi:T265_11739"/>
    <dbReference type="CTD" id="20325907"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="30" mass="3449" checksum="23C24501C8CB89BD" modified="2014-10-01" version="1" fragment="single">AVDDDDGDDDDEEEDEDEDDEDEDDDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWE0</accession>
    <name>A0A074ZWE0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_03341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166066.1">
        <property type="nucleotide sequence ID" value="XM_009167802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWE0"/>
    <dbReference type="STRING" id="6198.A0A074ZWE0"/>
    <dbReference type="GeneID" id="20317528"/>
    <dbReference type="KEGG" id="ovi:T265_03341"/>
    <dbReference type="CTD" id="20317528"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16164">
        <property type="entry name" value="OCRE_VG5Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035624">
        <property type="entry name" value="AGGF1_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="513"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="66723" checksum="D8EFF7FE3AC16536" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWM2</accession>
    <name>A0A074ZWM2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">T265_03246</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165943.1">
        <property type="nucleotide sequence ID" value="XM_009167679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWM2"/>
    <dbReference type="STRING" id="6198.A0A074ZWM2"/>
    <dbReference type="GeneID" id="20317433"/>
    <dbReference type="KEGG" id="ovi:T265_03246"/>
    <dbReference type="CTD" id="20317433"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006787">
        <property type="entry name" value="Pinin_SDK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04697">
        <property type="entry name" value="Pinin_SDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="14 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Pinin/SDK" evidence="24">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="23">
        <location>
            <begin position="125"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="276"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="382"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KER30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="436" mass="50247" checksum="929D245CD8C84839" modified="2014-10-01" version="1">MTAVEAIDVLRQNLELAKEQLKNVDEDIRKMTGRDPVDDRYRLVVSSSVFLLRFPRRPAETGYRRPEVNKDFKLPGLRPTQVAVAKEELARIPEEDLQVSLASSVVRVAETRSRSDATKEMRKSDRDRGRRMLGILQGTLNQFRAESAAAIFKPQMAKRLQVDKKLEARAEEERQKLRRERAQLFRARREQQMEVALLQQKMRLLKGFEMWKTEMEKMIGFCRTETSPHIFFRPKVHNEESRRRVLETEEVINDIIRHRRRKIDIGFEESAISRRRQFVSQTDKDMDSDHEESTEQHSPRDWSPPRKISTGKSSEFSTGKARQPGSVVNRITASGKRRHTSAAQMDTGELSDASETFAIEGDEEPQLMEEEHTTVVMTTTHSGLPVSSSLVNNTGNTFRSKDRQFEEDSLTSKSDTRTVRMDDPSTEDTTMTDAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWY8</accession>
    <name>A0A074ZWY8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_11625</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597160">
        <property type="protein sequence ID" value="KER19659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176591.1">
        <property type="nucleotide sequence ID" value="XM_009178327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWY8"/>
    <dbReference type="STRING" id="6198.A0A074ZWY8"/>
    <dbReference type="GeneID" id="20325793"/>
    <dbReference type="KEGG" id="ovi:T265_11625"/>
    <dbReference type="CTD" id="20325793"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="269"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="17">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER19659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="819" mass="91152" checksum="42AFA3945B5D3D5E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXA0</accession>
    <name>A0A074ZXA0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_05101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168282.1">
        <property type="nucleotide sequence ID" value="XM_009170018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXA0"/>
    <dbReference type="STRING" id="6198.A0A074ZXA0"/>
    <dbReference type="GeneID" id="20319283"/>
    <dbReference type="KEGG" id="ovi:T265_05101"/>
    <dbReference type="CTD" id="20319283"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="366"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="626" mass="70677" checksum="F5A1305AC6E79CB6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY11</accession>
    <name>A0A074ZY11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UAA transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative solute transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168069.1">
        <property type="nucleotide sequence ID" value="XM_009169805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY11"/>
    <dbReference type="GeneID" id="20319119"/>
    <dbReference type="KEGG" id="ovi:T265_04937"/>
    <dbReference type="CTD" id="20319119"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47211" checksum="5ABEAF8DE7D281AD" modified="2014-10-01" version="1">MSKPTKSSQYPQVTTGLCDELTHFRIVASSDESESTNSDIHCSSSACLRTCKCTISRWHSIGVPLLLGQVLAGMIAATAVCSTFLANAGVSVPLSQNLFHYCFLFLCYFPPRLFCLFRRRQSYQLDRNCKTPTTRFCTKDRLYRASLYILAGLIDTHANWSFVAAYKFTNVTSIQLLDCLTIPVAVLLSIIFLRSRFFWTHYAAVIICLAGAGGMVAMDVLVNPTGPQIPTNTSGNITVLVESSSNVILGDFLVILGSVAYAASNVLQQYLVIRYGFLDFLAFVSLAALVHTAIYSLTLERTALFSILSGSPSSNHALIFGCLAGYVAAMFSLYSLMPYVLAKTSAVLVNLSLLTADVYALLIGIYLFHYGFHVLYLLCFSVILFGVGLFSFRAPLTRQTHLRCLSCLSEQSVYEVTVVQDALGSKRTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY90</accession>
    <name>A0A074ZY90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165344.1">
        <property type="nucleotide sequence ID" value="XM_009167080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20316953"/>
    <dbReference type="KEGG" id="ovi:T265_02765"/>
    <dbReference type="CTD" id="20316953"/>
    <dbReference type="OrthoDB" id="6265491at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149312" checksum="8F0B960275F7C546" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYA4</accession>
    <name>A0A074ZYA4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165276.1">
        <property type="nucleotide sequence ID" value="XM_009167012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYA4"/>
    <dbReference type="STRING" id="6198.A0A074ZYA4"/>
    <dbReference type="GeneID" id="20327228"/>
    <dbReference type="KEGG" id="ovi:T265_13060"/>
    <dbReference type="CTD" id="20327228"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000345">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF54">
        <property type="entry name" value="GROWTH FACTOR-INDEPENDENT 1B TRANSCRIPTION REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="664" mass="73966" checksum="5947FACFBC9FA44F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYF4</accession>
    <name>A0A074ZYF4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167914.1">
        <property type="nucleotide sequence ID" value="XM_009169650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYF4"/>
    <dbReference type="STRING" id="6198.A0A074ZYF4"/>
    <dbReference type="GeneID" id="20318994"/>
    <dbReference type="KEGG" id="ovi:T265_04812"/>
    <dbReference type="CTD" id="20318994"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="190"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="499" mass="55385" checksum="A7E997E0235833BA" modified="2014-10-01" version="1">MSSFEVVHTHEIPAFVDKIIVSGLNRTEESLIKKQALVQSTNVKDLFERVSEAKKRLDKLGVFRYVYALVDVAEEPSKYRVIFKVEEKRPATGRISLTHGTDGVSKMCGSVRLNNLLRGAEFADLDLEVGSNQLTTKVATLSKPLERNPYVRFSFGGTEGHWDHWWARFLRHERSVFSDVAVETAYGVHKFQWDANWREVEARDNTTPWAVRKESGAALKVGLKHTFEHDTRSDMVFPDSGFLFRLSKELATISPGSPTGQMAPDKVTSPSVARPSDDRAFQLKVEGLAHKPFRLTDWLVGEVTCSAGLTHSLSRHPIHIVDRFFLGGPLELRGFQWRTVSPMQPLLEPTPFNLPTADVVNETVDTTQTSTASRSPVGSDGFWLTGAHFYTPLPFFGAEEGSLASHFRLHAFCLAGSTLDSPVQRVLDSIAASTSDQTSLARRLLTELSSQPRAVVGGGLVIRFAGLLRIEINYCVPFKSQPGDLLKSGFNFGFGIAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ40</accession>
    <name>A0A074ZZ40_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167670.1">
        <property type="nucleotide sequence ID" value="XM_009169406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ40"/>
    <dbReference type="STRING" id="6198.A0A074ZZ40"/>
    <dbReference type="GeneID" id="20318806"/>
    <dbReference type="KEGG" id="ovi:T265_04624"/>
    <dbReference type="CTD" id="20318806"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="586" mass="66200" checksum="9970FAD58053BC6D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ44</accession>
    <name>A0A074ZZ44_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163899.1">
        <property type="nucleotide sequence ID" value="XM_009165635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ44"/>
    <dbReference type="GeneID" id="20315764"/>
    <dbReference type="KEGG" id="ovi:T265_01576"/>
    <dbReference type="CTD" id="20315764"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10841" checksum="0798422B4479B8C4" modified="2014-10-01" version="1">MLYRILDNSYLIEDSIERNDTRWMSKTSELVCLRSHLDYLLSDKLLNTQRQAKSESESTIHAASLQLDAKLSQGLQMSLLTDKPKRYVPVILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZM6</accession>
    <name>A0A074ZZM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_04513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167532.1">
        <property type="nucleotide sequence ID" value="XM_009169268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZM6"/>
    <dbReference type="STRING" id="6198.A0A074ZZM6"/>
    <dbReference type="GeneID" id="20318695"/>
    <dbReference type="KEGG" id="ovi:T265_04513"/>
    <dbReference type="CTD" id="20318695"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05484">
        <property type="entry name" value="retropepsin_like_LTR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034128">
        <property type="entry name" value="K02A2.6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="10">
        <location>
            <begin position="888"/>
            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1164" mass="130102" checksum="458FEFC0337F1B83" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZY4</accession>
    <name>A0A074ZZY4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163650.1">
        <property type="nucleotide sequence ID" value="XM_009165386.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZY4"/>
    <dbReference type="GeneID" id="20326935"/>
    <dbReference type="KEGG" id="ovi:T265_12767"/>
    <dbReference type="CTD" id="20326935"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057057">
        <property type="entry name" value="Spectrin_SYNE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF7">
        <property type="entry name" value="CALMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25034">
        <property type="entry name" value="Spectrin_SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2159"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2418"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2539"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3005"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3639"/>
            <end position="3661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4752"/>
            <end position="4784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1804"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2173"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2419"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2554"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2591"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3012"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="7532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="7532" mass="848937" checksum="20175AAED821299C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0B1</accession>
    <name>A0A075A0B1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163510.1">
        <property type="nucleotide sequence ID" value="XM_009165246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0B1"/>
    <dbReference type="GeneID" id="20315449"/>
    <dbReference type="KEGG" id="ovi:T265_01261"/>
    <dbReference type="CTD" id="20315449"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="9096" checksum="131183FD8CFF9C2C" modified="2014-10-01" version="1">MDSDHAFLCCWFSLRLSCLRKTHTSRLATKNFVDLEIKQDRERESVDGSMLRKALRNRTWRSECAFTSVVSYRHNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Y0</accession>
    <name>A0A075A0Y0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DIS3-like exonuclease 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein DIS3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_01106</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163313.1">
        <property type="nucleotide sequence ID" value="XM_009165049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Y0"/>
    <dbReference type="STRING" id="6198.A0A075A0Y0"/>
    <dbReference type="GeneID" id="20315294"/>
    <dbReference type="KEGG" id="ovi:T265_01106"/>
    <dbReference type="CTD" id="20315294"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF30">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="16">
        <location>
            <begin position="230"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="923" mass="102600" checksum="24412C600F67B171" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A178</accession>
    <name>A0A075A178_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin-tyrosine ligase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_12867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164233.1">
        <property type="nucleotide sequence ID" value="XM_009165969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A178"/>
    <dbReference type="STRING" id="6198.A0A075A178"/>
    <dbReference type="GeneID" id="20327035"/>
    <dbReference type="KEGG" id="ovi:T265_12867"/>
    <dbReference type="CTD" id="20327035"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF118">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="75108" checksum="536F5B404B0668F2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1B2</accession>
    <name>A0A075A1B2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anillin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162776.1">
        <property type="nucleotide sequence ID" value="XM_009164512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1B2"/>
    <dbReference type="STRING" id="6198.A0A075A1B2"/>
    <dbReference type="GeneID" id="20326759"/>
    <dbReference type="KEGG" id="ovi:T265_12591"/>
    <dbReference type="CTD" id="20326759"/>
    <dbReference type="OrthoDB" id="5817051at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anillin homology" evidence="2">
        <location>
            <begin position="260"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="997" mass="109999" checksum="5BA2E4C56A063A8F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F7</accession>
    <name>A0A075A1F7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162788.1">
        <property type="nucleotide sequence ID" value="XM_009164524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F7"/>
    <dbReference type="GeneID" id="20326771"/>
    <dbReference type="KEGG" id="ovi:T265_12603"/>
    <dbReference type="CTD" id="20326771"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF12">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="229"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="314" mass="35593" checksum="77AEB0A8D185E0A0" modified="2014-10-01" version="1" fragment="single">MDKNIGYLEHNNEYFNSGQWRHLITSMQHRNRLAVGCSARSANLLHEEWLGLSDQPNQLQRYLENAVNKDQSVVGFAFIECALVPAVQHGDWEIFDCFSGLLDSDHGIVTPVERGDKTSIKRNSEFYLFAKSSPPFSPQKDHLFDSCEMSELISVTRTNSSCNTFINSYASLRHFLENCLNASNSTQHLLNRVFDEEHSAALSHRHLPFPMLLATILVFTIMILVGTFGSGLVIFVVLRKPSMRTRSNLFIMNLAISDLTLCLFTQPFTLYRLLIGHHPWALGSFMCKFSAMFQGTNIFVSTISITAIALDRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I6</accession>
    <name>A0A075A1I6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164153.1">
        <property type="nucleotide sequence ID" value="XM_009165889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I6"/>
    <dbReference type="STRING" id="6198.A0A075A1I6"/>
    <dbReference type="GeneID" id="20327022"/>
    <dbReference type="KEGG" id="ovi:T265_12854"/>
    <dbReference type="CTD" id="20327022"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54322" checksum="472CAF5C5EFC927C" modified="2014-10-01" version="1" fragment="single">MIFQRYSTKHSRTKISHCKTTSSIRLEARSSRVPLSSVDITAETSADISIPKILEDEHLCLQESLLRVLQRNESVPPSLVKKFELLADSNMVDELREALVDINKLRSLYLKLFGQTRESLSHLHHDGPPPVPETPPPMSFEDELLNCMVDCNGDFLSEDDSTERSSQTSEKECEPKPNSAISPKEKSTRNTTDRIISNITENAVSNKKSDRDAVRSSQLKVPREEVISSLPSLSTNSADSVSHIFGGFSLRVLKVILKLITEQPEFQEAMQRRTFLTPPIVYADFYFIENVDRIIQEDYVPTLQDILVMREPSKAVREMLTTVGSTNLRIVDLGLQTLNLHRHLHYFESVSAVLFLVSLPDCLKRSYDLNRKGELETSVELFETLMCSPHMLKKEFVVFLNKLDLIREKFSDDGPNNEQEESMKERFLALKRKQDAKGSHISINVICALDVDEMREAIRESLRVIFEYNRKRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2S3</accession>
    <name>A0A075A2S3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10074</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596951">
        <property type="protein sequence ID" value="KER21654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174604.1">
        <property type="nucleotide sequence ID" value="XM_009176340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2S3"/>
    <dbReference type="GeneID" id="20324242"/>
    <dbReference type="KEGG" id="ovi:T265_10074"/>
    <dbReference type="CTD" id="20324242"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113861" checksum="9AA4303C29226D79" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A313</accession>
    <name>A0A075A313_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166224.1">
        <property type="nucleotide sequence ID" value="XM_009167960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A313"/>
    <dbReference type="STRING" id="6198.A0A075A313"/>
    <dbReference type="GeneID" id="20317647"/>
    <dbReference type="KEGG" id="ovi:T265_03460"/>
    <dbReference type="CTD" id="20317647"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="22742" checksum="DF2D7103CADFEF61" modified="2014-10-01" version="1">MLLYHPLSGPVCAGVVGQRMPRYCLFGDTVNTSSRMESNGLPLKIHISEASFNVLRTFKSFIMTKRGSMEMKGKGEQTTYWLHGEGNFIVDPVPEGEPLVGGPYDGAVGPLPIDTRPESHPTGDLSQSGRLQGNNRGAAPQNKGALLSQDSTLITIPEFPATNPSEAIIPEEFVNPKDRSKRRIGICHPQSIQVPCDNDTNVTKLETAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3H4</accession>
    <name>A0A075A3H4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Axonemal dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161991.1">
        <property type="nucleotide sequence ID" value="XM_009163727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3H4"/>
    <dbReference type="STRING" id="6198.A0A075A3H4"/>
    <dbReference type="GeneID" id="20314258"/>
    <dbReference type="KEGG" id="ovi:T265_00070"/>
    <dbReference type="CTD" id="20314258"/>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="21134" checksum="8C1D19B53AA05B89" modified="2014-10-01" version="1">MGTKWVKHVSAKQATPIEMTHVKQEVDRVLKVRCSRKAPLCVIREDVLSDLIREILRQVTIDCPEQGLLLRRILDHNEMEFNAYETLLRFTDAFVGRKWAEWQHWKADRARQISELEDTKRILEFQAAELKHKVDQLEKKNQEMKIKWDAARMEEIKYYKKTGEHLRNLLPSFGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3M4</accession>
    <name>A0A075A3M4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER21999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174237.1">
        <property type="nucleotide sequence ID" value="XM_009175973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3M4"/>
    <dbReference type="STRING" id="6198.A0A075A3M4"/>
    <dbReference type="GeneID" id="20323964"/>
    <dbReference type="KEGG" id="ovi:T265_09796"/>
    <dbReference type="CTD" id="20323964"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7920" checksum="0D07F82FD81FAA12" modified="2014-10-01" version="1">MYAAGVEEVKALLLARANELANRRPEDRRRSSVFERSHKIASDLCLQPYNPAPTAPRLSVIPFTPICQVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3P3</accession>
    <name>A0A075A3P3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596924">
        <property type="protein sequence ID" value="KER22019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174211.1">
        <property type="nucleotide sequence ID" value="XM_009175947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3P3"/>
    <dbReference type="GeneID" id="20323941"/>
    <dbReference type="KEGG" id="ovi:T265_09773"/>
    <dbReference type="CTD" id="20323941"/>
    <dbReference type="OrthoDB" id="10450849at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705432" evidence="2">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="296" mass="32109" checksum="DF0F6BD978536643" modified="2014-10-01" version="1">MKGSITLLLELILLWGIFGQGTGLSLIKNENDIGIPNQKEAASDGFEKDGDESTFLASEFPGHTTDEDTQEPTSAADVTESHPTVLQEAEENGPSQGESPSDQLQDGEHTTENVPASQGTEEDSSTVHQTEVVSPIQEEDSTVHVEADQDTTENVPASQGTEEDSSTVHQTEVVSPIQEEDSTVHVEVDQDATEILHGSVEINEIPTRPQLDENESCRQDEGPIFHDLSYGFSGQDTQETKVTDMQYKVTSKSEKTEHPDSGMQHDADEQDVESASPASQQPFLSLLVLPLAVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Y2</accession>
    <name>A0A075A4Y2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="4">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162791.1">
        <property type="nucleotide sequence ID" value="XM_009164527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Y2"/>
    <dbReference type="STRING" id="6198.A0A075A4Y2"/>
    <dbReference type="GeneID" id="20314866"/>
    <dbReference type="KEGG" id="ovi:T265_00678"/>
    <dbReference type="CTD" id="20314866"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="258" mass="28928" checksum="D1188CF77C8EE03D" modified="2014-10-01" version="1">MYAANHPSLLPLISTSLLPQIAVGSAYSFKLSRNGRVVVCYFGEGAASEGDAFTALNFAATLDCPIIFICRNNGYAISTPVREQYRGDGIVSRAPALGIVGVRVDGNDLFAMYNVTKAARHLCINESRPVLIEAMTYRVGHHSTSDDSSVYRSVDEVNYWDKSNNPILRVRNYLVRKEWLTEEEEKQIRADCRKQVMTVFGISEAKKKPNPALMFSDVYDTMPPRLHRQMLATKEHVDRHTDAYPLNAFEPFNTSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A516</accession>
    <name>A0A075A516_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165642.1">
        <property type="nucleotide sequence ID" value="XM_009167378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A516"/>
    <dbReference type="GeneID" id="20317187"/>
    <dbReference type="KEGG" id="ovi:T265_02999"/>
    <dbReference type="CTD" id="20317187"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10408" checksum="3E59B64A56279C75" modified="2014-10-01" version="1">MVIRPCKLRQSRRCGNSPTDGCQEDIQLPTSRRRKDEIISSDELRPGENMCRPLIWGGDASPPAKVPFCLFGSLMCLRDSSRIYLPGSKLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A579</accession>
    <name>A0A075A579_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165501.1">
        <property type="nucleotide sequence ID" value="XM_009167237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A579"/>
    <dbReference type="STRING" id="6198.A0A075A579"/>
    <dbReference type="GeneID" id="20317072"/>
    <dbReference type="KEGG" id="ovi:T265_02884"/>
    <dbReference type="CTD" id="20317072"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="583"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="977"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111253" checksum="1D570F555D36846F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5A9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="20314786"/>
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    <dbReference type="CTD" id="20314786"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7478" checksum="1EEAF3103B87CA18" modified="2014-10-01" version="1">MAVCFIKETTHKIAENSSTTHDRFRPSWGSSVSYPPAAPELLKMPVFDAISVSLFIQPGCHYHTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5L5</accession>
    <name>A0A075A5L5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18844" checksum="E8E501E170932F25" modified="2014-10-01" version="1">MSGKPPVAHLTEETIVEYRDAFDSFDYSKAGKLSPLDIPILMRKLGLMPSNLEVEEMIEEIYKEKDTAADGITFEQFCCIAARKYNDIYKEADIIEAFRTFDLEEHGYVSSAELRRVLCGMGEKLTDDEFEAMLYQAKMDEDGNVHYETFVRRMMEDMYQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A618</accession>
    <name>A0A075A618_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2CD3 N-terminal C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165215.1">
        <property type="nucleotide sequence ID" value="XM_009166951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A618"/>
    <dbReference type="STRING" id="6198.A0A075A618"/>
    <dbReference type="GeneID" id="20327224"/>
    <dbReference type="KEGG" id="ovi:T265_13056"/>
    <dbReference type="CTD" id="20327224"/>
    <dbReference type="OrthoDB" id="79771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2CD3 N-terminal C2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="460" mass="51299" checksum="96503D17F4FF5523" modified="2014-10-01" version="1" fragment="single">PNPIPRSPSGSSCPVQVHTSLPPGIQAPVTAYLILKISSFRCVSRHVSTDRRSNSRNLPDGLSVYVRWWGEPATNPCAVFTPRLSHKAGHKQITSTTARYEITVPQERFKAYLKDMNILYMNVVDSACVRFIGRARLDHIERLSMENPVHTVLPVTDEVGEKLGELTVSISIEVVVDASSKQPNARVSGDVRSPQLPQRRLDEPADGESAHCLPDPTQSRPQDEQQDQQPPISCISKEHVIDEDLSDDGINPDISAQPDSSPLVRPPPTDGDHQTHKLNALFHHFNRNLISKPIESRQLPESEQCTGGRHMSNGMLRSSDMLAPQFTGIPSANRFPSNPELHLGSLSLDDQNPPCDGLLENTRRLLSLIHSQPVDSNVASVNQLLFSSPHDDPIEGTCNLEDSPIQHFSQNEHLVEELFFPSNNHPREILFQSFELLLDVQLLPLKERRPSLRSFFIGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A859</accession>
    <name>A0A075A859_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164386.1">
        <property type="nucleotide sequence ID" value="XM_009166122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A859"/>
    <dbReference type="GeneID" id="20316172"/>
    <dbReference type="KEGG" id="ovi:T265_01984"/>
    <dbReference type="CTD" id="20316172"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8407" checksum="E4AFF9AC1A9EB87F" modified="2014-10-01" version="1">MYGGLQFMLSESPRGGSHTEFQVPMLIMSDHRSGVVGKQPFDMKDLPEPNNDKTKLDQQSELCSVLNYQDYVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9A7</accession>
    <name>A0A075A9A7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163867.1">
        <property type="nucleotide sequence ID" value="XM_009165603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9A7"/>
    <dbReference type="STRING" id="6198.A0A075A9A7"/>
    <dbReference type="GeneID" id="20315732"/>
    <dbReference type="KEGG" id="ovi:T265_01544"/>
    <dbReference type="CTD" id="20315732"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17312" checksum="19B046B103139B05" modified="2014-10-01" version="1">MSGFDSEAAARILRWIRALKKPPSMHGPCWEASKKLPQDVQSIGSNEFGDYLKDGLALGYIMACLDPTLVHEVLENPIWEVSDKTTFEKLRQKERIRLFLQFLTSLNIESSDQFSVSGLNEKLDLERVVQCLREVTLMVGHLNGCTGPVEFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACA5</accession>
    <name>A0A075ACA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162721.1">
        <property type="nucleotide sequence ID" value="XM_009164457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACA5"/>
    <dbReference type="GeneID" id="20314817"/>
    <dbReference type="KEGG" id="ovi:T265_00629"/>
    <dbReference type="CTD" id="20314817"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704583" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11170" checksum="9C9DD930EA60796C" modified="2014-10-01" version="1">MIRTWFILTMLLVGVKSSEVQTGSTGLKNVLCRLCETLLSVLKTDEKARNELKTRIENACINFQVLAKVCPSISGKFISETVKMLQANEPKDICKSFTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACJ8</accession>
    <name>A0A075ACJ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162579.1">
        <property type="nucleotide sequence ID" value="XM_009164315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACJ8"/>
    <dbReference type="STRING" id="6198.A0A075ACJ8"/>
    <dbReference type="GeneID" id="20314699"/>
    <dbReference type="KEGG" id="ovi:T265_00511"/>
    <dbReference type="CTD" id="20314699"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="494" mass="54805" checksum="00C58E4F9E841D18" modified="2014-10-01" version="1">MTVTTATVSSELWPLHDAMENGHMCLSLSTGNTMLVKCSPASPGIHTTIGNANNSNTEPMQISTITTTTTTTTTTTTTTCSALSTLMQLANFPSSFLPGSRRTASELDHDVNDTVRCTGCRSLILDPFYHRVVDQSWHQACLRCFTCGILLLDRCYTKEGQMYCRADFPHHPTTTTTTTTCSALSTLMQLANFPSSFLPGSRRTASEVDHDVNDTVRCTGCRSLILDPFYHRVVDQSWHQACLRCFTCGILLLDRCYTKEGQMYCRADFMRQYGPRCTACRKTIQASELVHFARSSIFHAACFRCNICDHQFIAGDQLCLARGDQYVICQEHYTAPPPTGRMAIQQLVERSEGAVSDFHLSSVRPLTPSTPSFNSCRQSSTSIEGSMEKENRAQVLEDDAGTMASSAEDGSFRKTSPSPVSSQSRLMQIHNRLPKRESGKSLRMYAHSQSLQTPPSNPTYLATYLKTFTPRNRSEKEAPSLMDGLTTRLISILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACT4</accession>
    <name>A0A075ACT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00469</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162506.1">
        <property type="nucleotide sequence ID" value="XM_009164242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACT4"/>
    <dbReference type="STRING" id="6198.A0A075ACT4"/>
    <dbReference type="GeneID" id="20314657"/>
    <dbReference type="KEGG" id="ovi:T265_00469"/>
    <dbReference type="CTD" id="20314657"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="19127" checksum="FC34CD52229BA7FB" modified="2014-10-01" version="1">MFAGVALPVFTACFLCLVVTVLVWFLLRKKRSSVLILGICDSGKTTLFAQLHHGATMPTHTSLKENIGKFQTEKEIYVQRSDGPGDCVLPTKVPDRLQQAGLYLGKGQAKSPDIVIAGVMNAQVGRLSAAKARLGGCLGLDTRRTDNGDRLLCVCADHRLFLCSTNFRNSGYRPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFB7</accession>
    <name>A0A075AFB7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168716.1">
        <property type="nucleotide sequence ID" value="XM_009170452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFB7"/>
    <dbReference type="GeneID" id="20319627"/>
    <dbReference type="KEGG" id="ovi:T265_05445"/>
    <dbReference type="CTD" id="20319627"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="202" mass="22931" checksum="AF8ED216318639CD" modified="2014-10-01" version="1">MLRCQLRLTVPESSPSYTKLAEESSTRPTVLWIRSTWHDRLFLQNVQSLDTPLTIQGKPQQVVVLDPTGLCLIRSPHEPQRPGSYLLSCMTCGAKKRISNEASRKRVFGCAAGTSIRGTSSIIDYDDSVMCYACRNTVYRDEWERYRFTPRASRTVILRNAGICCSSSGCSQLAFLVWLNLLEMDFSYYSQRGHYSTEARPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFG6</accession>
    <name>A0A075AFG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168508.1">
        <property type="nucleotide sequence ID" value="XM_009170244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFG6"/>
    <dbReference type="GeneID" id="20319451"/>
    <dbReference type="KEGG" id="ovi:T265_05269"/>
    <dbReference type="CTD" id="20319451"/>
    <dbReference type="OrthoDB" id="6236025at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="205" mass="23617" checksum="6841450DE700A66C" modified="2014-10-01" version="1">MCYADYKTLHMHSNLIQRPASVSRTHNYTRHTHECSRCRLPWPLMVIVRPVSTCNAECEASTIPGSLVYSQAMARHAHNRARCHLLRKREHSGLANSGPRGLKAPEVSKADSPDFSESSTSGSERRAYTRTNQTQRSAPNYLRLRSRNNEAVKRFRQKSKNQTRSLEDEIARHGPYVLLEPKLDCFREIHSFANQFGFHERISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGN8</accession>
    <name>A0A075AGN8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Progesterone-induced-blocking factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167354.1">
        <property type="nucleotide sequence ID" value="XM_009169090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGN8"/>
    <dbReference type="STRING" id="6198.A0A075AGN8"/>
    <dbReference type="GeneID" id="20318551"/>
    <dbReference type="KEGG" id="ovi:T265_04369"/>
    <dbReference type="CTD" id="20318551"/>
    <dbReference type="OrthoDB" id="299638at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026205">
        <property type="entry name" value="PIBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950:SF0">
        <property type="entry name" value="PROGESTERONE IMMUNOMODULATORY BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18950">
        <property type="entry name" value="PROGESTERONE-INDUCED BLOCKING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="89410" checksum="E1E0737D0BD3AE18" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI04</accession>
    <name>A0A075AI04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle control protein 50A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165437.1">
        <property type="nucleotide sequence ID" value="XM_009167173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI04"/>
    <dbReference type="STRING" id="6198.A0A075AI04"/>
    <dbReference type="GeneID" id="20317017"/>
    <dbReference type="KEGG" id="ovi:T265_02829"/>
    <dbReference type="CTD" id="20317017"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36477" checksum="A6ACC8F2B009B4A8" modified="2014-10-01" version="1">MFTARKSAITFLVLGVFFIPLGAILLATSDSVIEYSVDYTNCMDTTTGRPCMEVIGPGVVCSCIQEVVVAKDIPAPVYLYYGLENFYQNHRRFARSKSDQQLLGSKVSPSSLSSCTPYDTFTNNSVTYMILPCGAIANSIFNDTFEVTYRSSSTANPIPVSMTNKGIAWKSDITRKFGILTPETLADTVKPPNWPKPIEERSPGAFKSDEELMVWMRVAALPSFRKLHRRIVHEGQFQNGLPAGTYTFRISYVFPVSTFNGRKSFVIGNVSWLGGKNNTLGIMCLVTGFLHLLLGFAFLAVYLHSKRRANGPSVMIDPGQPQELNCLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIA2</accession>
    <name>A0A075AIA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164975.1">
        <property type="nucleotide sequence ID" value="XM_009166711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIA2"/>
    <dbReference type="STRING" id="6198.A0A075AIA2"/>
    <dbReference type="GeneID" id="20316650"/>
    <dbReference type="KEGG" id="ovi:T265_02462"/>
    <dbReference type="CTD" id="20316650"/>
    <dbReference type="OrthoDB" id="6240715at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="356"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="448"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="746" mass="84321" checksum="B5284892A396BA89" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIP8</accession>
    <name>A0A075AIP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164235.1">
        <property type="nucleotide sequence ID" value="XM_009165971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIP8"/>
    <dbReference type="STRING" id="6198.A0A075AIP8"/>
    <dbReference type="GeneID" id="20327037"/>
    <dbReference type="KEGG" id="ovi:T265_12869"/>
    <dbReference type="CTD" id="20327037"/>
    <dbReference type="OrthoDB" id="6234546at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="36198" checksum="9DC5A2EC66B7FA74" modified="2014-10-01" version="1" fragment="single">MMHKLHTPDLLSDKISSRFVALIGNSHPGSITPLWNTLIHKQMQHRPCVVVTSGELSYSCLKGDCPNLYFLHTDDIDSSEGAFKKLRDIVSNRDDSQLVCLFIECIPWFFLDCPNDFEFGFYTRHVISLMFDLAIHPMVKRLTVVFNPIRSTTGAFLSYSSDICTTLEQCATSILRCGKPDSVTSGRNECCVQLPLTVFHKRSAQYAFSHLADEQPSIVNKPALFEQLVVDIDVNLLEFVGFHRVVNDLDQPTTQQQPEASFALQVTDSERIARAQVALPYEFAQTELSSSHPVDDVQIHYQPDCFDDFDDEDPDDDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIU6</accession>
    <name>A0A075AIU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164009.1">
        <property type="nucleotide sequence ID" value="XM_009165745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIU6"/>
    <dbReference type="GeneID" id="20315867"/>
    <dbReference type="KEGG" id="ovi:T265_01679"/>
    <dbReference type="CTD" id="20315867"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="79" mass="8735" checksum="5E84E7D76456AFC2" modified="2014-10-01" version="1">MNLTTHRRYRSVGHALDRQVNDLNWNSGIKEIEDSAKKEESASEGDEAEDEEDESAGNMPIEASSSHYNLNAAGNNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIW5</accession>
    <name>A0A075AIW5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163894.1">
        <property type="nucleotide sequence ID" value="XM_009165630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIW5"/>
    <dbReference type="GeneID" id="20315759"/>
    <dbReference type="KEGG" id="ovi:T265_01571"/>
    <dbReference type="CTD" id="20315759"/>
    <dbReference type="OrthoDB" id="76173at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="40648" checksum="160EB3B38D1536B0" modified="2014-10-01" version="1">MNDGNYTNPMRTGGLLPLDLARLGQHNSVPAVVLPFSGVAVRHRKDVTAASCGSGPVDSQRIPKRLAIQGVSNGKAHFVAKFVIPEKSRVELVVNRIEYPLQPCSNFGYLPDEILLPIEKSQDELVLNEEFTSSAQKMIIDVIEHKPSVAFGKLLSFRAQFLLNKPASSGENITTRNLIPPMCHFSVDALSIDCPLRFLRVRTPKLISSALARSLETSLLFPVNPTQTKELIDLAVDLRFGYLSVTSFNEFSVHLDSDPSALSANLAGFVHQRYRHDDTGPYGRVAVCVPRRPIELYWGLGRLAAYCRADKRKHAFDDAFLLALPRFPSSTLSSPNLNTFSAGSSSRTNRFARSASHSAAATVYPSSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ00</accession>
    <name>A0A075AJ00_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163687.1">
        <property type="nucleotide sequence ID" value="XM_009165423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ00"/>
    <dbReference type="GeneID" id="20315585"/>
    <dbReference type="KEGG" id="ovi:T265_01397"/>
    <dbReference type="CTD" id="20315585"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12195" checksum="CB043D6577DF5C9E" modified="2014-10-01" version="1">MAHGSVDIEKLVSKYTTYMGCDYLFYLAVVGGGERADGETKRSEQTTVCPSSSQEKQYSRCGRDSSGWNNLLSKSVNKGAKKKAIRSVVQLFFNPTDFCCNPGEDAHHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ40</accession>
    <name>A0A075AJ40_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163458.1">
        <property type="nucleotide sequence ID" value="XM_009165194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ40"/>
    <dbReference type="STRING" id="6198.A0A075AJ40"/>
    <dbReference type="GeneID" id="20315397"/>
    <dbReference type="KEGG" id="ovi:T265_01209"/>
    <dbReference type="CTD" id="20315397"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="608" mass="66714" checksum="5BEC93742EA459FB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJP6</accession>
    <name>A0A075AJP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_12536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162524.1">
        <property type="nucleotide sequence ID" value="XM_009164260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJP6"/>
    <dbReference type="STRING" id="6198.A0A075AJP6"/>
    <dbReference type="GeneID" id="20326704"/>
    <dbReference type="KEGG" id="ovi:T265_12536"/>
    <dbReference type="CTD" id="20326704"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="225"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="499" mass="56498" checksum="DA7966C1026D298C" modified="2014-10-01" version="1">MSEFHSAFGVDREKIANDSDYVHKTMYYDYPPDNLMPFGKKFKFFSRFKHKRKTSVPDEDHAPLTVDDGDIQKYRRQNRLSASYTSLDSPNHRVSSSSTLEEVDKVEDGRANGAGAGNRSPVEDDESQNGVYDFDSEDNPQFATLVPTFPPIGVSPITCDITSGKFRGIDTALSHLVDDLKFDKEQRIAKADQIIKAIHALEQVRLPKFLGFSMLTEPGEPSDLYELKETLGSGASGIVCRALERKTSQEVAIKILQLARQTQPEMVVTEIEVLRALKHENIVNYLGSFLRRPLDQLWVVMEYLDGGCLADFVTEFKMESRMIAAVTKECTKGLAYLHDRNIIHRDVKSDNIMLGRRGNVKITDFGFCAQLANPFGRRNSVVGTPYWMAPEVANQDTYGTKIDVWSLGIMVIEMVDGDPPYSGMQPLQAMLIIQTSARPTPKAKRLDPYLHDFLDVCLEVDPRKRATSRQLLRHRFLKRACPLNDLIPFIELTCQYTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTS1</accession>
    <name>A0A074YTS1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607948">
        <property type="protein sequence ID" value="KER18166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178087.1">
        <property type="nucleotide sequence ID" value="XM_009179823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTS1"/>
    <dbReference type="GeneID" id="20330413"/>
    <dbReference type="KEGG" id="ovi:T265_16248"/>
    <dbReference type="CTD" id="20330413"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="34" mass="3862" checksum="E69512C14F5EA121" modified="2014-10-01" version="1" fragment="single">VGRTRCALLSVLTPNKDETSIWTSYVYRDIAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVT6</accession>
    <name>A0A074YVT6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597998">
        <property type="protein sequence ID" value="KER18783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177470.1">
        <property type="nucleotide sequence ID" value="XM_009179206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVT6"/>
    <dbReference type="GeneID" id="20326324"/>
    <dbReference type="KEGG" id="ovi:T265_12156"/>
    <dbReference type="CTD" id="20326324"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="7090" checksum="E0FBFFDE522BF554" modified="2014-10-01" version="1">MRRDFRSRGAEILDDTYDSDTSNLPGDPRKTSIFLMVVDQSETINFLQRELRCPENSHLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWP9</accession>
    <name>A0A074YWP9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597295">
        <property type="protein sequence ID" value="KER19191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177061.1">
        <property type="nucleotide sequence ID" value="XM_009178797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWP9"/>
    <dbReference type="STRING" id="6198.A0A074YWP9"/>
    <dbReference type="GeneID" id="20329789"/>
    <dbReference type="KEGG" id="ovi:T265_15624"/>
    <dbReference type="CTD" id="20329789"/>
    <dbReference type="OrthoDB" id="10053156at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="311" mass="35206" checksum="B014731344CA7B63" modified="2014-10-01" version="1" fragment="single">AIIKRTATSDEANLQRLPAGVELGDLTPSQLLRHMQSLACGKSFDDTILKPLWLQSDVPLSLPPLKFVALPLLDSDSFIVAQGLLFLKNIDALYSTTSTQFLIPAKLVSQRYAWPNMQDEIRTWAKQRLDCQTSKTQRHTISPTAIFQLPDSHFRNVHIDLVGRLPPFRGFTHILTCIDRFTRWPMAIPINDLSAKNTARIFVDSWIATFGVPATIITDRGPQFTSTLFHDLKRLRGTDHFRTTAYQPAANGMVERFHRQLKATLIASSSTHWSERLSLIIFSIHNTVKKTWAAQPLNSSSVLPYAFQVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX66</accession>
    <name>A0A074YX66_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597223">
        <property type="protein sequence ID" value="KER19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176858.1">
        <property type="nucleotide sequence ID" value="XM_009178594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX66"/>
    <dbReference type="GeneID" id="20325987"/>
    <dbReference type="KEGG" id="ovi:T265_11819"/>
    <dbReference type="CTD" id="20325987"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="228" mass="25584" checksum="6FD6E411347A345F" modified="2014-10-01" version="1">MICNIVGIDPLDGFNVTDVLRIGEYSLRNFNFQTIVTMKSRPPFLDRFSGKLGLGPASDVTPGNFAQSLLTAFPDEPVFTFWFRPDHDGVFRGGIFSFGGIHDYRYDGPLIYLPMMLPTSWTVQATRPLLQASFAQWGLGRESTDRNVRGSKLTSSSQLPVSMLGQPGSILALVISLGRDITCHQGCTIQFNTAYPYFYGPPQQIHQIHQLLRVDRNLFRRGRIPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXD8</accession>
    <name>A0A074YXD8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597201">
        <property type="protein sequence ID" value="KER19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176787.1">
        <property type="nucleotide sequence ID" value="XM_009178523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXD8"/>
    <dbReference type="STRING" id="6198.A0A074YXD8"/>
    <dbReference type="GeneID" id="20329697"/>
    <dbReference type="KEGG" id="ovi:T265_15532"/>
    <dbReference type="CTD" id="20329697"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="27074" checksum="6495017523D9E3A3" modified="2014-10-01" version="1" fragment="single">RRRKFPSNSFINCFPEGIFRPYCQTACTVRSCGLKLSYIEYMLDRYFQVLLFVIHQTISDTQPSVLLPYLNINGPVHQKSLVNETVRLRCHVTVLMSNHSSAVFTPKLDFQNQTPTKWYAITPDSLNPTVKLSVQWIKDGFGYDADALLHTFGGRYRMLGSSTKGDFTLTINELTFEDEGEYACQASLVLQNPKLWSSDRTEQDPQKRTPDNDTLRGSTITMLPMSLIKSETASVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXL6</accession>
    <name>A0A074YXL6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597219">
        <property type="protein sequence ID" value="KER19408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176848.1">
        <property type="nucleotide sequence ID" value="XM_009178584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXL6"/>
    <dbReference type="GeneID" id="20329715"/>
    <dbReference type="KEGG" id="ovi:T265_15550"/>
    <dbReference type="CTD" id="20329715"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="21726" checksum="3D0A2F8B5E3CE784" modified="2014-10-01" version="1" fragment="single">KVEQFLKKLTESLDEAEKKLQTDDEEIKQKLSETLLKTLEHLKEEITKYLSELIKTITSEISSLDGNQTQAKGVASIYVINALKNINDFLTRELQRLKEALEQLNEKLEAFFTISSVANSGARETLGDQLNTTLKQAEEQITMILKNVKTGLQSRLSELETKLKERSADTSGAFLPNKCLFACPLQKMGESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYQ2</accession>
    <name>A0A074YYQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intraflagellar transport protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176465.1">
        <property type="nucleotide sequence ID" value="XM_009178201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYQ2"/>
    <dbReference type="STRING" id="6198.A0A074YYQ2"/>
    <dbReference type="GeneID" id="20325691"/>
    <dbReference type="KEGG" id="ovi:T265_11523"/>
    <dbReference type="CTD" id="20325691"/>
    <dbReference type="OrthoDB" id="444379at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="76733" checksum="A8E4A96E42204734" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0G0</accession>
    <name>A0A074Z0G0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597059">
        <property type="protein sequence ID" value="KER20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175827.1">
        <property type="nucleotide sequence ID" value="XM_009177563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0G0"/>
    <dbReference type="GeneID" id="20325193"/>
    <dbReference type="KEGG" id="ovi:T265_11025"/>
    <dbReference type="CTD" id="20325193"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34671" checksum="AE449F3C7D4B488B" modified="2014-10-01" version="1">MCLRKKEPRLRVTAIFQLNKGPLGWRNIKTVGGLALLGLRKQMMTLEPIYDTSREPAYKYKTLELILCHASQVETFTLLVDFVRALVWHAARLRHPLEQQAAILSPSEYRARLSLFLTAFQRRTWKEPERLVRKSRLSVSPHVLAELEPQHPHGAAVLFQGVCRTLQLPPNPDRKSTNRPRELQQSHYSSAPSRNVDHLCCSRFELLHPRPIRSSDRPTTGALEPSQHWEPLCSCSDRCSLHPTVGAPEPPVGSLPTVAQFDSTNFTAERPTKDGKLKDESTKKQYSQNPQMIARQPPRVLMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1C5</accession>
    <name>A0A074Z1C5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL597023">
        <property type="protein sequence ID" value="KER20768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175484.1">
        <property type="nucleotide sequence ID" value="XM_009177220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1C5"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20324923"/>
    <dbReference type="KEGG" id="ovi:T265_10755"/>
    <dbReference type="CTD" id="20324923"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703726" description="Hemoglobinase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER20768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="387" mass="44505" checksum="DC2D8B9C99F743CC" modified="2014-10-01" version="1">MKLQISLNVMRRFLLLIAFLFCIAHVACLEAAGVHNWSSIFNNNPSKNWVILVAGSNGWVNYRNQADVFHAYQVVRKNKVPAENIITLAYDDIAKHRKNPFKGKVFHDYEHEDVYKGVVIDYRGKEVTRDNFVRALKGDDKLEANKKKVLKSGPDDNVFIFYSGHGAASAIFFPDVVLYAMELNDTLAYMYSKRMYNKLVLYVDACSSGSMFRDVLPSNMGTKEDEKSWSMFCYDKEIDACLANEYSYAWITDSEYSDLKKRTLEQQYQEVKKRTKDSHVMKYGELAIGSLPVGKFQGHYDLLMHRNNGAIAPNVVDRKISSRVHLFSMSRCTMEATTEEEQEAAWRKLHRALQVYEVAHHTTHLMELCKAGYEAETLIEYILNVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z223</accession>
    <name>A0A074Z223_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175228.1">
        <property type="nucleotide sequence ID" value="XM_009176964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z223"/>
    <dbReference type="GeneID" id="20329348"/>
    <dbReference type="KEGG" id="ovi:T265_15183"/>
    <dbReference type="CTD" id="20329348"/>
    <dbReference type="OrthoDB" id="10357912at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19400" checksum="C6C2ABCDFEA7A8F7" modified="2014-10-01" version="1" fragment="single">MSNTSVPNEYEIVRICELFWVCRTKLKLNGTGEICEKFTRTFHRNTNNARFAEACVSGSSMFKVLFAKLLTVSYRSSIGNGPSALVPDTDPCVDGLLELLTVEVAENVMVNRKFGTCVTRHCPGGDDDVTMAGLSLHALGQSSNPKLVYRTQIATKHKSVRDEMRNPIKMSDDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z297</accession>
    <name>A0A074Z297_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596992">
        <property type="protein sequence ID" value="KER21118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175124.1">
        <property type="nucleotide sequence ID" value="XM_009176860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z297"/>
    <dbReference type="GeneID" id="20324646"/>
    <dbReference type="KEGG" id="ovi:T265_10478"/>
    <dbReference type="CTD" id="20324646"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11535" checksum="033D00497268CA85" modified="2014-10-01" version="1">MFTTGTPPLAVRIEQIFTQNGNQWTERCCRNHKTDCTFIIVVKLANRSVRRNSTCIPPYHWHSGAATAEKSIPRKIGQEFGTLAGPAPRRNPIGRKFGPKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2F2</accession>
    <name>A0A074Z2F2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596990">
        <property type="protein sequence ID" value="KER21148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175099.1">
        <property type="nucleotide sequence ID" value="XM_009176835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2F2"/>
    <dbReference type="STRING" id="6198.A0A074Z2F2"/>
    <dbReference type="GeneID" id="20324626"/>
    <dbReference type="KEGG" id="ovi:T265_10458"/>
    <dbReference type="CTD" id="20324626"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="420" mass="46910" checksum="BBFE1F508100D17F" modified="2014-10-01" version="1">MQMRARFGQRNAPVECSSNREKRSGPLETRIVQQMDDDLGALIVHDQFSGKWFYKMRGTANRVARLLCLRCHGNSNAIETGILMASITYVESSQWDTDHRLREFLRIVKLSACDYALCFLAFGQCPAIDALFRQDSVSSGNTEAILNSSFIPSGTTIPVTTASPTNDEALLKFSQGNYLLKTPRQLTPGFALLGAHQRFDETSPLTGQDTFAVEPDATEAFCFSSSSHAQRLKQRRLKHHHVSMEFGIHHPLPSCPLDCFWAANCLTTGQRCWSRANPDVDPEVDNRDLQAGPTFSRLSQDSANFLTPVLAHRPSESLRVDSIWSHPWFRRGLLRRLTPVAPPPRAVSTNRETHRENLESLVPYRALLPPEAPVPSSQRVYTCLTQADPTANDLRLSQPADMTSILMVSQSANPDLDFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2R1</accession>
    <name>A0A074Z2R1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596973">
        <property type="protein sequence ID" value="KER21351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174897.1">
        <property type="nucleotide sequence ID" value="XM_009176633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2R1"/>
    <dbReference type="GeneID" id="20329273"/>
    <dbReference type="KEGG" id="ovi:T265_15108"/>
    <dbReference type="CTD" id="20329273"/>
    <dbReference type="OrthoDB" id="6268062at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36933" checksum="F01C8977015BB281" modified="2014-10-01" version="1" fragment="single">MQIGMDPVTVELVKHGPAYSMGVFPTTHLDLSIMNSTVKVHEFRCRFPSSFLALITNYLGYLIFSPEDTKEIQNALIKEAKALRNVSGEQSYARLISDSSLPAQTRKRSSRTSGIDKQRFILRRPGNQSNTNELERKLFPPRLNIWTCSKDQTDELVHRPAMVPEVLSILRGYDTSVLASVLARILRPHGVGLIPCYLRSLFLQLVSNTVESEIHQRRAIRLLFQLVPTRLLGMVIRPVFELLAGIANEPTCEVDEYSLAILFSPILFLDQSTTTPASLASPLPARAVELLVRTALRDLQSHQSLDRTFRVPVLFQKDCLRNLTQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Q2</accession>
    <name>A0A074Z3Q2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174564.1">
        <property type="nucleotide sequence ID" value="XM_009176300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Q2"/>
    <dbReference type="STRING" id="6198.A0A074Z3Q2"/>
    <dbReference type="GeneID" id="20324214"/>
    <dbReference type="KEGG" id="ovi:T265_10046"/>
    <dbReference type="CTD" id="20324214"/>
    <dbReference type="OrthoDB" id="6412411at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="2">
        <location>
            <begin position="481"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="665" mass="75823" checksum="569779C350568A3A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4W3</accession>
    <name>A0A074Z4W3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174129.1">
        <property type="nucleotide sequence ID" value="XM_009175865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4W3"/>
    <dbReference type="GeneID" id="20329101"/>
    <dbReference type="KEGG" id="ovi:T265_14935"/>
    <dbReference type="CTD" id="20329101"/>
    <dbReference type="OrthoDB" id="6226041at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9752" checksum="FB9BAD133E13D08B" modified="2014-10-01" version="1">MLSAWLCSVAGLLLICHACVTFRMNEGDSVYAMTDDPMDKCIAACYVCFLQMEEAMLNCVNSICQASESMKFPEKPEQLCASLRALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z579</accession>
    <name>A0A074Z579_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597033">
        <property type="protein sequence ID" value="KER20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175583.1">
        <property type="nucleotide sequence ID" value="XM_009177319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z579"/>
    <dbReference type="STRING" id="6198.A0A074Z579"/>
    <dbReference type="GeneID" id="20325004"/>
    <dbReference type="KEGG" id="ovi:T265_10836"/>
    <dbReference type="CTD" id="20325004"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1268" mass="143833" checksum="D96B0D56A477755E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5D0</accession>
    <name>A0A074Z5D0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596907">
        <property type="protein sequence ID" value="KER22283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173945.1">
        <property type="nucleotide sequence ID" value="XM_009175681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5D0"/>
    <dbReference type="GeneID" id="20323740"/>
    <dbReference type="KEGG" id="ovi:T265_09571"/>
    <dbReference type="CTD" id="20323740"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="14029" checksum="F2CC1D3FF8022E4C" modified="2014-10-01" version="1">MHPRNYLTLPYKYSCSKPERFNSEPSASLVRHLCPPRGNVHELGRLRGPADFRYLNQVGSQYFRVALKFPEEAQRHRLGNLQLPDHCFECVMSWLNYRGQLIEVVHATSEPSSSRTLLTGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5N4</accession>
    <name>A0A074Z5N4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596901">
        <property type="protein sequence ID" value="KER22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173865.1">
        <property type="nucleotide sequence ID" value="XM_009175601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5N4"/>
    <dbReference type="STRING" id="6198.A0A074Z5N4"/>
    <dbReference type="GeneID" id="20329032"/>
    <dbReference type="KEGG" id="ovi:T265_14866"/>
    <dbReference type="CTD" id="20329032"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120545" checksum="84E5A8800E589470" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z621</accession>
    <name>A0A074Z621_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596890">
        <property type="protein sequence ID" value="KER22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173657.1">
        <property type="nucleotide sequence ID" value="XM_009175393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z621"/>
    <dbReference type="GeneID" id="20323525"/>
    <dbReference type="KEGG" id="ovi:T265_09352"/>
    <dbReference type="CTD" id="20323525"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="17140" checksum="529CD15C9A14E43B" modified="2014-10-01" version="1">MDHCPLQGEANSRLDKHMDPTANKIPLSAWCKPLIRRPETIRISTSCDADVSCTFSTHPSPSHGYPYLDRKLQRAIQGRISWNIRYNRGQPKAASRLSTEVPACFLRFRRWGVRLSIGWEDFKEAAAVTMVENEDIPEYRTDEIDRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z655</accession>
    <name>A0A074Z655_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596888">
        <property type="protein sequence ID" value="KER22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173637.1">
        <property type="nucleotide sequence ID" value="XM_009175373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z655"/>
    <dbReference type="STRING" id="6198.A0A074Z655"/>
    <dbReference type="GeneID" id="20328975"/>
    <dbReference type="KEGG" id="ovi:T265_14809"/>
    <dbReference type="CTD" id="20328975"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="404" mass="45594" checksum="04F88B18DFFC18A4" modified="2014-10-01" version="1" fragment="single">MSIYASALDRVAEILSRPPAQRMETETKEVASWLQRKVKAFECVPVGVLMKLVEECGSEWRCANELIIREGDIGTCQLARWLGREFTDQKVRGSNPASDCRLPLSRLGQPGSIPALEKYWTQVSFLLELTVAHIQWPCRDLNPGNLTYEASVMYILLSGSASVYQLGDLEEDVDDRLGGATSAAETSEKGDASAPVITIGQRGSIVKDTTVLGRCVGLLRRRRPRGFCQLMFYLKPNCTKLANIQQLNVLHQVASCFSRYDIRDIAIQSGAIFGEVALIEECRRIASIVANPISRDQDAKLSTEIPKERKKDDKEKTDQVSPSAQELAVQLVVIPRALYDKTVRSILEAQFRMRTDFVNQVPYFRRLNSRLKEQIILSLEIQTFEYGCEIFRAGSEYRGFYYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7V9</accession>
    <name>A0A074Z7V9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596856">
        <property type="protein sequence ID" value="KER23286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172969.1">
        <property type="nucleotide sequence ID" value="XM_009174705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7V9"/>
    <dbReference type="GeneID" id="20322977"/>
    <dbReference type="KEGG" id="ovi:T265_08798"/>
    <dbReference type="CTD" id="20322977"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="48" mass="5530" checksum="B900A369DD5785CC" modified="2014-10-01" version="1" fragment="single">EDGCRFCKFIKYGADNHYDYKCEKGICVENKAGDYCCEHENCNLSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8M7</accession>
    <name>A0A074Z8M7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172668.1">
        <property type="nucleotide sequence ID" value="XM_009174404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8M7"/>
    <dbReference type="GeneID" id="20322738"/>
    <dbReference type="KEGG" id="ovi:T265_08559"/>
    <dbReference type="CTD" id="20322738"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="23803" checksum="718F3614B79B3F31" modified="2014-10-01" version="1">MNETTASTDNISLLSKITTTGIYANRGLIALQVQVDKSRCESGCSHTSSLISVSEAPRPSTWAFLAGNLILFEHKSGHFGKNFLDLYELFLIVVDFATLAQNGDPPLYKPVVAVPLTVPKIDEYYRKTNKYRVHARICTADELEFSASPLWCGFTRIIALGHEDDFLNKSDVNVNSTFPANPKTDIKKLSSGFQTSVALPDREVLTSGWSIDRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBH6</accession>
    <name>A0A074ZBH6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596872">
        <property type="protein sequence ID" value="KER22942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173315.1">
        <property type="nucleotide sequence ID" value="XM_009175051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBH6"/>
    <dbReference type="STRING" id="6198.A0A074ZBH6"/>
    <dbReference type="GeneID" id="20323251"/>
    <dbReference type="KEGG" id="ovi:T265_09072"/>
    <dbReference type="CTD" id="20323251"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="128"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="571" mass="63638" checksum="11883B0BED65B96D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBL6</accession>
    <name>A0A074ZBL6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171701.1">
        <property type="nucleotide sequence ID" value="XM_009173437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBL6"/>
    <dbReference type="STRING" id="6198.A0A074ZBL6"/>
    <dbReference type="GeneID" id="20321987"/>
    <dbReference type="KEGG" id="ovi:T265_07808"/>
    <dbReference type="CTD" id="20321987"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="388" mass="44193" checksum="4E888A8A8BE87F9E" modified="2014-10-01" version="1">MPTGDQDFEDEVERDREHFIRTLASFRFFGVHMLKKLERTKSYYESIPDRQKALASEFCSYMEKVKASVLHNNELLNRIIKHSAPDIFNGEHSADVLDTFDKSSLQLSNAKRKSANTNAVTPIGPFAFTTSDMDKVRSTLKQFARDWSNVGKAERDICYEPIIHDICELYDTSKIDPVTVRILVPGAGLGRLAWEIAHRGYTCQGNEWSLHMLIPAYFILNNCKTVNEHTIYPWVTQFCNNMSRDDQIAPVHFPDVSPADIPPNVPFSMAADSWDCVATVFFIDTAHNVLTYLETIWRILKPGGYWINFGPLLYHFSDIPGEDSLELSYEELRLAIQRIGFTTVKEKTGIRCGYTQNPASMLSYEYNCVYGLFQKPLSASTCSNDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBZ4</accession>
    <name>A0A074ZBZ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173128.1">
        <property type="nucleotide sequence ID" value="XM_009174864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBZ4"/>
    <dbReference type="GeneID" id="20323104"/>
    <dbReference type="KEGG" id="ovi:T265_08925"/>
    <dbReference type="CTD" id="20323104"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13673" checksum="AC10B4872286709B" modified="2014-10-01" version="1">MRSYLAHLPKSSERNCGSYNHCTASTWLLQLAMMMMINRQTIFPASVHVKTNTKGAKGLLTPKTKSGTVVQRFVYIASRPDAGPANVPNFGPTSSGPGFSAVAAPKDVRYSGIRVDSCLTALEKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCC7</accession>
    <name>A0A074ZCC7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-processing factor 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171426.1">
        <property type="nucleotide sequence ID" value="XM_009173162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCC7"/>
    <dbReference type="STRING" id="6198.A0A074ZCC7"/>
    <dbReference type="GeneID" id="20321777"/>
    <dbReference type="KEGG" id="ovi:T265_07598"/>
    <dbReference type="CTD" id="20321777"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="12">
        <location>
            <begin position="231"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="895" mass="98921" checksum="A76026F7EBA2CA9F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCM1</accession>
    <name>A0A074ZCM1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171357.1">
        <property type="nucleotide sequence ID" value="XM_009173093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCM1"/>
    <dbReference type="GeneID" id="20328481"/>
    <dbReference type="KEGG" id="ovi:T265_14315"/>
    <dbReference type="CTD" id="20328481"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15604" checksum="03F25FE80A5C5402" modified="2014-10-01" version="1">MYARETWLLRTADVRRLQRISNKVIGKPVSGCVAAPSTALAQPCATHDKTPSIGTSFALRVFFKHKQHTSRRMTLKEGVKENTKSLDVVFFIRSGGPIGCSFYPVSSFADAHVTFELGIPRRRSLVDVGVTFVLPSSGCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCT4</accession>
    <name>A0A074ZCT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAU2 chromatid cohesion factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cohesin loading complex subunit SCC4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171290.1">
        <property type="nucleotide sequence ID" value="XM_009173026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCT4"/>
    <dbReference type="STRING" id="6198.A0A074ZCT4"/>
    <dbReference type="GeneID" id="20321672"/>
    <dbReference type="KEGG" id="ovi:T265_07493"/>
    <dbReference type="CTD" id="20321672"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="838" mass="93273" checksum="28876C50B1E8FA3C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCY9</accession>
    <name>A0A074ZCY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase kinase kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171222.1">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
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            <begin position="1447"/>
            <end position="1742"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
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        </location>
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            <end position="1804"/>
        </location>
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        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
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        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
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        <location>
            <position position="1476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER25048.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1814" mass="198705" checksum="93F13FD517A01F29" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEG8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_10109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="8841" checksum="DE1D93BB6552E9C5" modified="2014-10-01" version="1">MKLVIPKDHPIHSTSNGIVGTVQGPSTFTKWYPMSFKVSDTSTGDITSRLASKQSEPGQKFTPTRGVINNEMSPTEFNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFX8</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_07824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20322003"/>
    <dbReference type="KEGG" id="ovi:T265_07824"/>
    <dbReference type="CTD" id="20322003"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9230" checksum="A80C1651C08DAB50" modified="2014-10-01" version="1">MTRSILSEKFGGDSVSPLFHKQNLMMVVDQVNDVVGDGDDDADEDDRENVYDGDNGEDEEGNDDRFSYDDGGAGGMQKCAEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG31</accession>
    <name>A0A074ZG31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596913">
        <property type="protein sequence ID" value="KER22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG31"/>
    <dbReference type="GeneID" id="20323824"/>
    <dbReference type="KEGG" id="ovi:T265_09656"/>
    <dbReference type="CTD" id="20323824"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38204" checksum="E5C946212543D1C7" modified="2014-10-01" version="1">MGNDYLPETNIHRDRLKLFISTLKSVYASIVSLMFCRVGALCTEEIDQKSAQMEIANKLQEVGYPVSLIKRQLRKLLAPASRPSKEWIGTVVIPYKAGTSEVIRRLLSLAIQLRSVLAQVKGPLSVGRTRECAYKINCNDCAKICMGQTVRELHTRIGEHKRRINKPLGNVEEYQTLVKDSAMAAHAVDTGHRVDLKNLEFLRRGLRFTPQRLRAEAMEITKHHSVNRIEGVELASVWKAVRQLNVLHQAASCFSRYDIRDIAIHVYLCNALLIMLLKIHRQPTTGFVVTEKGGDLVQHIQLPGNITNETFSWVPGLLVNLSSPSAVQKILERAGSIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG61</accession>
    <name>A0A074ZG61_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170067.1">
        <property type="nucleotide sequence ID" value="XM_009171803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG61"/>
    <dbReference type="STRING" id="6198.A0A074ZG61"/>
    <dbReference type="GeneID" id="20320699"/>
    <dbReference type="KEGG" id="ovi:T265_06520"/>
    <dbReference type="CTD" id="20320699"/>
    <dbReference type="OrthoDB" id="2138378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="253" mass="27616" checksum="E056E69F995D94F5" modified="2014-10-01" version="1">MGSTQMSLNPEVADLVKSLAANLSATPSVITASSSVTPENSQPVFTPKPIDSTVPWNEPNHVTESGTASDQSLQRELWDVLEENYPDLNVRELSADRIRDLLEPLRDQLVARGIFQLPYAEKYPVSFPPPQLSPPRPHSSYGMRPGYPGHRPPQLMSLFPRPDFLPAHPRPGPPPGGFRPVPPPVQNRPPPFLSGGPPPHYSRAPGPMHGGSQPPHRPAPYSRGGGRGSQLCKFFQQGSCRNGSACPFLHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGD1</accession>
    <name>A0A074ZGD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596906">
        <property type="protein sequence ID" value="KER22315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173932.1">
        <property type="nucleotide sequence ID" value="XM_009175668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGD1"/>
    <dbReference type="GeneID" id="20323728"/>
    <dbReference type="KEGG" id="ovi:T265_09559"/>
    <dbReference type="CTD" id="20323728"/>
    <dbReference type="OrthoDB" id="10470065at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8508" checksum="16C99A94DBF841BD" modified="2014-10-01" version="1">MPVLDPNHSHLELLPAIANLLTGKSVVGTRPLQLDFSCQSLANLAVFETSCFPRVTWQLGTERVLQLNDLSYSFSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHD6</accession>
    <name>A0A074ZHD6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596888">
        <property type="protein sequence ID" value="KER22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173627.1">
        <property type="nucleotide sequence ID" value="XM_009175363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHD6"/>
    <dbReference type="STRING" id="6198.A0A074ZHD6"/>
    <dbReference type="GeneID" id="20323503"/>
    <dbReference type="KEGG" id="ovi:T265_09330"/>
    <dbReference type="CTD" id="20323503"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="134"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="593" mass="65851" checksum="BE50867E8501E0E3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHX7</accession>
    <name>A0A074ZHX7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169378.1">
        <property type="nucleotide sequence ID" value="XM_009171114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHX7"/>
    <dbReference type="STRING" id="6198.A0A074ZHX7"/>
    <dbReference type="GeneID" id="20328081"/>
    <dbReference type="KEGG" id="ovi:T265_13914"/>
    <dbReference type="CTD" id="20328081"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="2">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="26420" checksum="8C7E6729C67CDB74" modified="2014-10-01" version="1" fragment="single">WFNQLTQRGQFLGRLSRCGTNQSHCSIKNTFTRSRVIIHVSSACSGGLVVIHSPRTSDVRNSDLDTAPLMSSSPFFIGNAFRIQTITTGLGPSLSVRPVVTRSPPSCSSVNCLVREIAQDFKTDLRFQSSVVQAKQEVSEAYLVGLFEDTNLCAIHAKVLSLSRVTDFSQATLETCCPKNLASTSSSQYHRRPQSSINTFICSDLKNHMHPAYAGAVLTRSHRMSDVRSSNLGTNKDMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI39</accession>
    <name>A0A074ZI39_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173287.1">
        <property type="nucleotide sequence ID" value="XM_009175023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI39"/>
    <dbReference type="STRING" id="6198.A0A074ZI39"/>
    <dbReference type="GeneID" id="20323233"/>
    <dbReference type="KEGG" id="ovi:T265_09054"/>
    <dbReference type="CTD" id="20323233"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="379"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="796" mass="88471" checksum="5C77A59FC1110C2E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ36</accession>
    <name>A0A074ZJ36_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172884.1">
        <property type="nucleotide sequence ID" value="XM_009174620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ36"/>
    <dbReference type="GeneID" id="20322914"/>
    <dbReference type="KEGG" id="ovi:T265_08735"/>
    <dbReference type="CTD" id="20322914"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="16043" checksum="352205340227FBD0" modified="2014-10-01" version="1">MVFSSSSCQLAVFELVGLHAHCSQQVSDIPHFYDVFLLLCNPYPTNPPVMLHSDSKHMIMPDSPGSRRSDKMICHVEYVNCRNSTPKDKWQVDVLRRHRQKSHNGVLGLKMLHPPSTMYAIIHPSWVWSSPKKDTSMISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJF1</accession>
    <name>A0A074ZJF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170341.1">
        <property type="nucleotide sequence ID" value="XM_009172077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJF1"/>
    <dbReference type="GeneID" id="20328273"/>
    <dbReference type="KEGG" id="ovi:T265_14107"/>
    <dbReference type="CTD" id="20328273"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="57" mass="6035" checksum="78AA1ADC6A582290" modified="2014-10-01" version="1" fragment="single">DTNYCIFSDQNTEAETTTEKSQKTESTGAAKISESSRTAQQTKSTSTAKISEPSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJL1</accession>
    <name>A0A074ZJL1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168699.1">
        <property type="nucleotide sequence ID" value="XM_009170435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJL1"/>
    <dbReference type="GeneID" id="20319610"/>
    <dbReference type="KEGG" id="ovi:T265_05428"/>
    <dbReference type="CTD" id="20319610"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9715" checksum="B836F8638CF352B7" modified="2014-10-01" version="1">MIAVKQKAKDDDLSTKIRSLQGHSVHPPSDEALGCVVVVVNRNLSPALQQSHGAIRDPMLEWGWSGCTANVISSSEYCFGYLFLMVPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK32</accession>
    <name>A0A074ZK32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168816.1">
        <property type="nucleotide sequence ID" value="XM_009170552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK32"/>
    <dbReference type="GeneID" id="20319700"/>
    <dbReference type="KEGG" id="ovi:T265_05518"/>
    <dbReference type="CTD" id="20319700"/>
    <dbReference type="OrthoDB" id="10419788at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8510" checksum="1DBFE36378BD4386" modified="2014-10-01" version="1">MSDCFNSSIVFCPAQVDPIASDIHTPKRLKHEAVWCSTFSCLRTSQTRDSAGFQVILSQNQISLQMSVYSLRINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL31</accession>
    <name>A0A074ZL31_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168203.1">
        <property type="nucleotide sequence ID" value="XM_009169939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL31"/>
    <dbReference type="GeneID" id="20319221"/>
    <dbReference type="KEGG" id="ovi:T265_05039"/>
    <dbReference type="CTD" id="20319221"/>
    <dbReference type="OrthoDB" id="6245365at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="298" mass="32794" checksum="EDD82DC394F54E9D" modified="2014-10-01" version="1">METGQHRQQNQVVGLGRPTSLLTAPPAYQHRQTHSFGTGITDGPWRRGEVICAGKVDHNLVDHGNFRLLSHNGIRRPGRGRNSWWSRGRRRPNYSSHYAGSPVYPPAGAGQPRGQIVYRNALRRTWNASMPQCLQHCGLAGQTGSTDDGFIDDTLLTDINQFSLHESSSDYFEIYDQSESVAVIQKRHLTSTASSDALDEADQQDQIKHPLGKSENCVSKLDESLVKGGSSGLGERPEDGYDEQQESRQDLKPAALGVPSLHGARTPTDYMTLVWDSNLTDDTDPSLDLKSDDLAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLF6</accession>
    <name>A0A074ZLF6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168051.1">
        <property type="nucleotide sequence ID" value="XM_009169787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLF6"/>
    <dbReference type="STRING" id="6198.A0A074ZLF6"/>
    <dbReference type="GeneID" id="20319101"/>
    <dbReference type="KEGG" id="ovi:T265_04919"/>
    <dbReference type="CTD" id="20319101"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="469" mass="52956" checksum="F16C249B53A8F01A" modified="2014-10-01" version="1">MTGRWRKFIHAQYLNCATFEPFAELRAYTTNIELYIYLNDLTEYATCPDCFNNEVKSQLSGALIVIHPADYLPDVNDKSINLKPGSLTEIRLSTVENVQKMPPYGRCSHDLPESVPLYGTEYAYSEYACRQATIQNEISAKCGCFSIEFPYSEHAGLEPCSRLPAFVNISSCDNVASATVNSTCAAQLTEFAQRMLCKRSVTERFAHGIVPSCTMPCAFYSYEAEQSTSTWPTKVWQLTWLNSSSIRRLGIFNGPEFQIYREAQTLLAQGNESAAARLLEHANLLERNLLAVLINRPNFDVRKVEEKEVLSLTSLLSQSGGLFSIWMGLTMIALGEIIEFFMRCFVKAKALRRNRNTLRPNSLPSDGNVSITSLMHKMSINREEQPGDEKPCKENHLLWLQLIAFMKQNSMQSHASFGIEPECVCSCMQSEKTSNNTLSWQRPSRSSVFRSHLPNINHGHRKSISTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMN0</accession>
    <name>A0A074ZMN0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169234.1">
        <property type="nucleotide sequence ID" value="XM_009170970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMN0"/>
    <dbReference type="GeneID" id="20320031"/>
    <dbReference type="KEGG" id="ovi:T265_05849"/>
    <dbReference type="CTD" id="20320031"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="16845" checksum="2C03351151A1EFEB" modified="2014-10-01" version="1">MLVFRYRTLSLGRYNDQKYLKGNLSPKVYGTLYTKGNRSTVTCFRCLAAMLSEGSMRAGMLPGRPSPDRGGRDVGFEPWIFRPYQSSQNVPSFAEIKKINRKDNHSVVTLYRCLAAIPLEGSTRAGILPGCSSLDKGSRETEVVNHRHSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMX4</accession>
    <name>A0A074ZMX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_04515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_04515"/>
    <dbReference type="CTD" id="20318697"/>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
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        <property type="entry name" value="VPS13B"/>
    </dbReference>
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        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS13_N"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1836"/>
            <end position="1862"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1844"/>
            <end position="1856"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="4830" mass="535757" checksum="0122AF6E43296140" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN52</accession>
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        </submittedName>
    </protein>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20318615"/>
    <dbReference type="KEGG" id="ovi:T265_04433"/>
    <dbReference type="CTD" id="20318615"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="10851" checksum="C6465EB2DF272385" modified="2014-10-01" version="1">MSSDSQRPKQCVHSRVEKRVEVRRSRQRLGLRSLTSGSGFHTQHRTESAQSLKHGNINRCGSSTCVGKSDEVGDGVFVAQLHLVDEKRASEDARYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A074ZNY5_OPIVI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="32681" checksum="2A4B9BD41284F9AB" modified="2014-10-01" version="1">MQSVVVNQNCNQPHALMVSTAMENRKETEDLKLSAKKQPTDLKALDELVFQEVTADTISSVSILGKRIVRQYASEFVLPDDTRVAVSRFEATKPSEDHEEVTLSLSIALRLNEQQLAKATAIADRQDDQGTDSGAVTSMSGTSSDEMFTDTSLGMDREHYYGTKYDWENPEHMDFDEAGIGREDIRTWIKHCRTPRGLRIVDYIDDDPWAATILLTNFSANADLLRQLETGCRTEPEAYRMERLQRRRNWETIIDVRREPTVRSIGLSRTHSETDSISTACTNVDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPZ3</accession>
    <name>A0A074ZPZ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05171</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="C:ribonuclease MRP complex"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pop1"/>
    </dbReference>
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        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="117"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="963" mass="108643" checksum="F4A508F9A2085353" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ60</accession>
    <name>A0A074ZQ60_OPIVI</name>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167063.1">
        <property type="nucleotide sequence ID" value="XM_009168799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ60"/>
    <dbReference type="GeneID" id="20318327"/>
    <dbReference type="KEGG" id="ovi:T265_04141"/>
    <dbReference type="CTD" id="20318327"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13764" checksum="45A1A9BC638A76C4" modified="2014-10-01" version="1">MESTSATGFKPHMEWLFYLSVPGNHLAEEAVWSDTWALTGVSVCESALLTQLLILFVLFTLRRLKKLREDRTTGQQTGSRLRMDWVLRIRKVTLVMCRNTGSSGEFLVVDQAAVDVFAELGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ62</accession>
    <name>A0A074ZQ62_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168267.1">
        <property type="nucleotide sequence ID" value="XM_009170003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ62"/>
    <dbReference type="GeneID" id="20319268"/>
    <dbReference type="KEGG" id="ovi:T265_05086"/>
    <dbReference type="CTD" id="20319268"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7634" checksum="EE641B195FEC5DF9" modified="2014-10-01" version="1" fragment="single">VARGPGKTTQGETDTRKTTIRLVNRLLWTNSTNPKQTGERLATGVCDKVDKQGHCRSGRKPGDTVDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQD1</accession>
    <name>A0A074ZQD1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170714.1">
        <property type="nucleotide sequence ID" value="XM_009172450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQD1"/>
    <dbReference type="STRING" id="6198.A0A074ZQD1"/>
    <dbReference type="GeneID" id="20328355"/>
    <dbReference type="KEGG" id="ovi:T265_14189"/>
    <dbReference type="CTD" id="20328355"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="414" mass="44600" checksum="3A409B4160D0665A" modified="2014-10-01" version="1">MQISNRTMFDKRQDIFFPGDSIVQKDDRHRCGPFTHISGGQIRASCMGRTKRCTSDGVTVVELVPLKTPGVVPYAGAIVLAKTLPHRDDYQRVSSQASIFPPGDLERHQPLCIPPQHLLDHQRTSCHNVPTPTVEDQEAVFVRPVTIDHPVGGEMAQWLEREFTDRGVRGSNLTSASRLPLSRLGQPGSTPALVLASGGMSARHRKGVTAERLFSQVISLEPSCLLVIQVSSLSRRIVRCDVVAVGNIPLAGPFRGMLRREDIRATQRDQAEPAQCYRPGDLIRARVINLLGPGSTPESTFLSGENVSSAAATTLLAARAVSVSVGATADISGGLASNAVCLLSTAEPDLGVVLGLGRAPDTDFAELLGSTSGCPLIPVSWTEMLCPHTLSRFPRKVARVSDELLTQLVKTEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR19</accession>
    <name>A0A074ZR19_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166342.1">
        <property type="nucleotide sequence ID" value="XM_009168078.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZR19"/>
    <dbReference type="GeneID" id="20317746"/>
    <dbReference type="KEGG" id="ovi:T265_03559"/>
    <dbReference type="CTD" id="20317746"/>
    <dbReference type="OrthoDB" id="6258003at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="10">
        <location>
            <begin position="40"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1297"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1306" mass="145573" checksum="5CE5CC76DC148346" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRL4</accession>
    <name>A0A074ZRL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_04700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167768.1">
        <property type="nucleotide sequence ID" value="XM_009169504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20318882"/>
    <dbReference type="KEGG" id="ovi:T265_04700"/>
    <dbReference type="CTD" id="20318882"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF185">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="541"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1301" mass="150080" checksum="31234D9EDC6D7925" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTA7</accession>
    <name>A0A074ZTA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169648.1">
        <property type="nucleotide sequence ID" value="XM_009171384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTA7"/>
    <dbReference type="GeneID" id="20320365"/>
    <dbReference type="KEGG" id="ovi:T265_06183"/>
    <dbReference type="CTD" id="20320365"/>
    <dbReference type="OrthoDB" id="10542686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="987" mass="113665" checksum="55B3E46021AB1291" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTT9</accession>
    <name>A0A074ZTT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165288.1">
        <property type="nucleotide sequence ID" value="XM_009167024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTT9"/>
    <dbReference type="GeneID" id="20316897"/>
    <dbReference type="KEGG" id="ovi:T265_02709"/>
    <dbReference type="CTD" id="20316897"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12912" checksum="3C747D3CDF1FCF76" modified="2014-10-01" version="1">MDRAKRSEPDVESVRVNLTRLGQSSNINLYVGSFVIDMTRIVDDKDARSKTIMLKNIINDRFSWKTDDDDDSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTW6</accession>
    <name>A0A074ZTW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165353.1">
        <property type="nucleotide sequence ID" value="XM_009167089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTW6"/>
    <dbReference type="STRING" id="6198.A0A074ZTW6"/>
    <dbReference type="GeneID" id="20327242"/>
    <dbReference type="KEGG" id="ovi:T265_13074"/>
    <dbReference type="CTD" id="20327242"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002110">
        <property type="entry name" value="Zinc finger protein 1053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001532">
        <property type="entry name" value="Zinc finger protein 483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="296" mass="32485" checksum="7DDA2CB4F5BF5507" modified="2014-10-01" version="1" fragment="single">MPRQEVLSQCSSNTCPRKSSIHHPFDFPCDHHPYAPAAVFGFPAPRWILPKQNCLNPEHIPYCTWTSLLPTNFVGNEAVAMCPSIQLSVDPDVDAGDRREQHTSLPPSTPKSEANDPPSCSVLTKSTGGHTEPKPDRAKRHPCDHCSKGFNRASDLVKHRRTHTGEKPFVCHHCGRAFSDSSSLSAHRRIHTGERPYTCSDCGKSFSVSSSLVKHKRIHTGEKPYQCDLCGRLFSDNSSFGAHKKRSQRCVPEITSASSTPTYPLNTSPTGSVTFPSLNKQCQTTSTCIVSTASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU54</accession>
    <name>A0A074ZU54_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169312.1">
        <property type="nucleotide sequence ID" value="XM_009171048.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZU54"/>
    <dbReference type="GeneID" id="20320095"/>
    <dbReference type="KEGG" id="ovi:T265_05913"/>
    <dbReference type="CTD" id="20320095"/>
    <dbReference type="OrthoDB" id="6241713at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018596229" description="Cystatin domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="350"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="1815"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="2504"/>
            <end position="2608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2846" mass="327216" checksum="56EF2703E595A0EB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUR6</accession>
    <name>A0A074ZUR6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165417.1">
        <property type="nucleotide sequence ID" value="XM_009167153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUR6"/>
    <dbReference type="GeneID" id="20327264"/>
    <dbReference type="KEGG" id="ovi:T265_13096"/>
    <dbReference type="CTD" id="20327264"/>
    <dbReference type="OrthoDB" id="6265193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="28670" checksum="3AC3D0334CC8B653" modified="2014-10-01" version="1" fragment="single">TQWTDPLCDCANSTLSEPTFEAFLGWIVVGRLFTQSMDPSVHPILGATGATLGVMALILVLFLMMLCIPWSKCRAGRRRTENARALQDDDPFGLEAFNGGYPLTLVDLFPPSMLPKLPNYQECVQDGGPPPPVSDDSASLAVPPPNPFRNERGRTITSVELVNGAIAVEFPRDEYSDTLEDPDNFPSTPPPSYSTLTSARSSLRRFFRRGSTLTQRSEPHTFANSPVTRNSAQSSTRQALPNETTRTQSCERNTHEAPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUX5</accession>
    <name>A0A074ZUX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165357.1">
        <property type="nucleotide sequence ID" value="XM_009167093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUX5"/>
    <dbReference type="GeneID" id="20327246"/>
    <dbReference type="KEGG" id="ovi:T265_13078"/>
    <dbReference type="CTD" id="20327246"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10308" checksum="03870AEAD1F81A44" modified="2014-10-01" version="1" fragment="single">AIGTGAGQQQIPQIDESTDITGGQADSTPPNLEATDKRTVLCRQSSKPNMPSLSSLPDLNNILPLCLPGRHQCEPVISCHISLRVVLPSESLYTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVK7</accession>
    <name>A0A074ZVK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597300">
        <property type="protein sequence ID" value="KER19174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177078.1">
        <property type="nucleotide sequence ID" value="XM_009178814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVK7"/>
    <dbReference type="GeneID" id="20329795"/>
    <dbReference type="KEGG" id="ovi:T265_15630"/>
    <dbReference type="CTD" id="20329795"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="18086" checksum="703924D066C25BDD" modified="2014-10-01" version="1" fragment="single">MYSVTQLILCNTGLDSQSPVLEGNPIKPRWWSTSTDSVPSDPTLLIAGVPETDNHMTAIAVTTSLVRRVGKLCWRFHQLTILVFRFALALESDNDKTDEYIDHKERDQDDLNISLLWWSSSAEYATQDLDVFQSSLNILLTRLLKTPPQPTTGFALLGAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW03</accession>
    <name>A0A074ZW03_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166215.1">
        <property type="nucleotide sequence ID" value="XM_009167951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW03"/>
    <dbReference type="STRING" id="6198.A0A074ZW03"/>
    <dbReference type="GeneID" id="20327417"/>
    <dbReference type="KEGG" id="ovi:T265_13250"/>
    <dbReference type="CTD" id="20327417"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000115">
        <property type="entry name" value="28S ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="163" mass="18074" checksum="EFE54E07E312F261" modified="2014-10-01" version="1" fragment="single">RLPGDLSFRYGGTPVFLQACCTCCSAFYRGSLVCPCLMSFSPIYETTRSLATLAYMAVMGPHQKKRPPNKPMDHKPFMKAIVLKTLIRKPKKPNSANRKCVRVRLSNGREVVAHVPGEGHNLQEHNVVLVRGGRTQDLIGVKHKVVRGKLDCAPVQKPSPNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWZ5</accession>
    <name>A0A074ZWZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kazal-type serine protease inhibitor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_02143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164581.1">
        <property type="nucleotide sequence ID" value="XM_009166317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWZ5"/>
    <dbReference type="STRING" id="6198.A0A074ZWZ5"/>
    <dbReference type="GeneID" id="20316331"/>
    <dbReference type="KEGG" id="ovi:T265_02143"/>
    <dbReference type="CTD" id="20316331"/>
    <dbReference type="OrthoDB" id="5985519at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF19">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704363" description="Kazal-type serine protease inhibitor domain protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="165"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29909" checksum="F1AE531B527998D3" modified="2014-10-01" version="1">MFHQVISLVLLLGFSAAWDISAQKNAKTKYVGTHTLEPCQQCDYTKCTIPTECKAGLVLDRCGCCRVCGLEESHLCNLEEEIALLSRGRSVVPWHGRCGRNLECRTRTDVDPKVIRKQNICYCLEPGLVCGTDGKTYTHCELEAEQALSNRTLEKMSDGPCRVKPKAELRVAGGLVKRGEKFTLVCEAVGYPRADVTWHLSKPGDQGISRKMPGDFEDVTVTTRGAKFENQVISFLQITDFKLDQEGDYRCVADNELGVDTATATLVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWZ8</accession>
    <name>A0A074ZWZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597158">
        <property type="protein sequence ID" value="KER19669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176582.1">
        <property type="nucleotide sequence ID" value="XM_009178318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWZ8"/>
    <dbReference type="GeneID" id="20325786"/>
    <dbReference type="KEGG" id="ovi:T265_11618"/>
    <dbReference type="CTD" id="20325786"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="32830" checksum="16C9FB6024082462" modified="2014-10-01" version="1">MLAEKLEALFSCFIHTGNHQQCASHESPTGPEQAAHIYVLSKCELNHTADQPLVAERLKLLAGMSRVRDSPEFRTYSNAKPQEEVIGLNLTNIVITDINITSKFVNFVCKENMQYPNKQEPQTPKYAEGFLSIRGFVQTIVLRRFLVKCCTCPGSYSVHSGYQTTLLIARNGFPIEKAIKIWIRKAARSPLRKVPAFVKFHINIAIPDYKYLTDRNYSTKTFRKTSFRVGVQYNGFIIWKQTDTQGQRVNLEFDVLCDQGARVNREMKCLGYSDHSSAQPNNQIQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY12</accession>
    <name>A0A074ZY12_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165387.1">
        <property type="nucleotide sequence ID" value="XM_009167123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY12"/>
    <dbReference type="STRING" id="6198.A0A074ZY12"/>
    <dbReference type="GeneID" id="20316986"/>
    <dbReference type="KEGG" id="ovi:T265_02798"/>
    <dbReference type="CTD" id="20316986"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="556" mass="62391" checksum="F8A251772A748094" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY80</accession>
    <name>A0A074ZY80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAT1 centre domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597088">
        <property type="protein sequence ID" value="KER20129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176117.1">
        <property type="nucleotide sequence ID" value="XM_009177853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY80"/>
    <dbReference type="STRING" id="6198.A0A074ZY80"/>
    <dbReference type="GeneID" id="20329551"/>
    <dbReference type="KEGG" id="ovi:T265_15386"/>
    <dbReference type="CTD" id="20329551"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAT1 centre" evidence="5">
        <location>
            <begin position="66"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135480" checksum="97F0EA70A8FCD1D3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZI2</accession>
    <name>A0A074ZZI2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163384.1">
        <property type="nucleotide sequence ID" value="XM_009165120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZI2"/>
    <dbReference type="GeneID" id="20315347"/>
    <dbReference type="KEGG" id="ovi:T265_01159"/>
    <dbReference type="CTD" id="20315347"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="189" mass="21305" checksum="22B876B27B81CA7C" modified="2014-10-01" version="1">MIVRPASSHWYKETSQFVIRFGAQCSFRDVSLSALPNATQPKRLAVMPPKGSTRAGILPSCPSPDRGSREAEIGLEKWAFLSVNSRSRPETSVKRVHYTDAFNYFTRTIRKNYKKTAQQNYNGLHILSTDAHSMLSVKVEPLSINLTLTEITDYDCDLTECNGKDMSIPVLDLKELLLICAQNVQFTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZL9</accession>
    <name>A0A074ZZL9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial-processing peptidase subunit beta</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_04504</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167523.1">
        <property type="nucleotide sequence ID" value="XM_009169259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZL9"/>
    <dbReference type="STRING" id="6198.A0A074ZZL9"/>
    <dbReference type="MEROPS" id="M16.973"/>
    <dbReference type="GeneID" id="20318686"/>
    <dbReference type="KEGG" id="ovi:T265_04504"/>
    <dbReference type="CTD" id="20318686"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="168"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="438" mass="49223" checksum="3BD16786786085D0" modified="2014-10-01" version="1">MPATQVTTLKNNGFRVASENWNTPTCTVGIWVDVGSRCESEANNGVAHFLEHMAFKGTDKRTQHSLELEVENKGAHLNAYTSREMTVYYAKCFTQDLPWAVELLSDILKNSKFESTQVERERGVILREMEEIESNYQEVIFDYLHATAYQGTPLGRTILGPVENVKSLKAADLKNFIKCNYKAPRMVLCAAGGVDHSQLAELAEKNFGDVPASYFEGEGTPNLDPCRFTGSEIRDRDDAMPLAHAAIAFEGPGWANPDTLALMVASSIHGAWDRSYGGGANVASKLAAQFFNEDSVHSFQHFFTCYHDTSLWGVYLTAEKMGLAEGVNAFMKEFVRMCTQITPHEIERAKNQLKTHLLLQLDGTTPICEEIGRHMLVYGRRIPLSEMLERIDGLTVTNVKDVCMSYFYDRCPAVASLGPIETMLDYNRLRDKTWWLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A085</accession>
    <name>A0A075A085_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597017">
        <property type="protein sequence ID" value="KER20829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175424.1">
        <property type="nucleotide sequence ID" value="XM_009177160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A085"/>
    <dbReference type="GeneID" id="20324870"/>
    <dbReference type="KEGG" id="ovi:T265_10702"/>
    <dbReference type="CTD" id="20324870"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="26164" checksum="4D4F758D7BF1F60E" modified="2014-10-01" version="1">MSASQFSALFPRAYFGPQPPPHPAVITTTVSSQLIHSLCMFDHLEHWKSSNAQLPTPPPQTIGERNWQLPPLCNKYEVLTTDNDDGDWENPLLRQAGSIPALVLYSSGMAVRHRKGATAERYILRPSLLDSLTFRSSHVLSVLQSGEELRISILTMLDGFMYLPANRAITSNIGYVPPVFCGPNLLQLRPMCSWYMVYRGKDDLLVRTLGQPGSVAVLMLSSGDMAASHRKDVAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0E8</accession>
    <name>A0A075A0E8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164552.1">
        <property type="nucleotide sequence ID" value="XM_009166288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0E8"/>
    <dbReference type="STRING" id="6198.A0A075A0E8"/>
    <dbReference type="GeneID" id="20327088"/>
    <dbReference type="KEGG" id="ovi:T265_12920"/>
    <dbReference type="CTD" id="20327088"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="629" mass="66576" checksum="BF6291ADE3CCE3C6" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0K1</accession>
    <name>A0A075A0K1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164420.1">
        <property type="nucleotide sequence ID" value="XM_009166156.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A0K1"/>
    <dbReference type="GeneID" id="20316196"/>
    <dbReference type="KEGG" id="ovi:T265_02008"/>
    <dbReference type="CTD" id="20316196"/>
    <dbReference type="OrthoDB" id="6286400at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704424" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="128"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="240"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="354"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="492"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1483"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1679"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1558"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1679"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1698" mass="185349" checksum="AC58C7093279573F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A155</accession>
    <name>A0A075A155_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167006.1">
        <property type="nucleotide sequence ID" value="XM_009168742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A155"/>
    <dbReference type="GeneID" id="20318282"/>
    <dbReference type="KEGG" id="ovi:T265_04096"/>
    <dbReference type="CTD" id="20318282"/>
    <dbReference type="OrthoDB" id="6255329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="252" mass="27918" checksum="9795B000A6B692B8" modified="2014-10-01" version="1">MYNRNRTPNAHYNCTPNERFPSRLSLTSTPTEQYPNYLLSPYGSPSFDPGTRSTPAFHQSLRFVGSPRPPAAASFNAPPAHFMPYPCASPVDQSSGYPSIYNSPMCPPSFRSNYSQNSIATPSYMSAREQLNNSMDATPSSFRGGRSSFLSSRHDRSTSSPHVGWITRALSDPWADIIPKQAPETGYCLVSRPLAQRHTVLFAPRQLRRKAGEEPVDETSLDPKRMSLEEFDGVIDGDSLPCFSELTNSNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1E1</accession>
    <name>A0A075A1E1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175073.1">
        <property type="nucleotide sequence ID" value="XM_009176809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1E1"/>
    <dbReference type="STRING" id="6198.A0A075A1E1"/>
    <dbReference type="GeneID" id="20324605"/>
    <dbReference type="KEGG" id="ovi:T265_10437"/>
    <dbReference type="CTD" id="20324605"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000096">
        <property type="entry name" value="G1/S-specific cyclin-D3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="476" mass="52649" checksum="40947C9E981F9042" modified="2014-10-01" version="1">MACAGEDAIVHDSDPSSTVPQPQFDPYFTANEKIIQDLLIDERRYHSTPAYCVKQPLAVAKWMRRALLTWVREICAYRRTDAGVLSQTAQLIDRYLHVVPIEKSQYQLVGAACFFISSKLKESTQVPLSEMVKFTDYSVQNVDILAYEMMVCLSLAWDLTCITPVDFIAPVVDFLEFVPELKQIIRQAALNIYTKVFHVEDLGLYMPSYMAAACILYALNLTVHPDLGDVTLRSVTRIQQLLRLEARKIREVYQHLQSCFKPGTIELSEAVIKADSGVVTPSPEPSVPPPPHQYVALTSNSAVPMPMATSTVLPTRPLCADASSHSNSLSSFGSSSGSFENASTHLASASISTCSPSETEFFNETENEQPPISELCVPRPSMPYVQYYHHPQAAQHPNAYAAGQILNNECVLATTNGWENAAVNLTGPLSKMNDYVTVKAAVFPGDPRFVILTAAGLPVATQRRWTPTDIRDVQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A285</accession>
    <name>A0A075A285_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163908.1">
        <property type="nucleotide sequence ID" value="XM_009165644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A285"/>
    <dbReference type="STRING" id="6198.A0A075A285"/>
    <dbReference type="GeneID" id="20315773"/>
    <dbReference type="KEGG" id="ovi:T265_01585"/>
    <dbReference type="CTD" id="20315773"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="348" mass="39533" checksum="5E657CAB3668E63E" modified="2014-10-01" version="1">MVKVLEDRYKLRIYAGYEPEFRIFRKEGFEESTRNKPGSQADTIIPPTPWTSGSDMLRYGHLSAYEFFVMDLDQYLQAAGIDIIEYLNENGSGEIETPLVPKFGIAAADTYFIFKHAVREIAKKHDMRVSFMTKPLVGELSTGCHFNHSLWDIERGKNVLFDSSASDNLSNLAHNWLGGLFEHMPALTALCSPTVNCYRRLHAGWAPGHMDWELDNRFVTVRLKNVGEDGTYLENRLSSSASCPYHVMAATLAAGMDGIERRLEPPSRGAYNPAKGAPIMKELPKTLKEAIDALKKDTILVDRLGNQFVDWFIRAKEFGDLKTLGQIDIKEESEEFLAQERYEYLEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A292</accession>
    <name>A0A075A292_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162695.1">
        <property type="nucleotide sequence ID" value="XM_009164431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A292"/>
    <dbReference type="GeneID" id="20314791"/>
    <dbReference type="KEGG" id="ovi:T265_00603"/>
    <dbReference type="CTD" id="20314791"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="24714" checksum="E59FFA4733D526B5" modified="2014-10-01" version="1">MLLDVQSLNTPLTIQGEALEVVEHFTYLGSCISSDCSVTDEVNARICKARAAFANLRHLWRQNGLSLNLKGCLGDLAVSQTLYFLLVAWQLGTERVLQIWQCSEPLASVRGSNPDTAIGYALMMSSNKSKTRVQCFPLRSYKRQLSAVLPTWGGPPPSKVEGPRKPGSHKAKKRTNEWQLLEPPEQDADKSSEDSVKILVHKPPQPFQQTTILTSRLALNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A397</accession>
    <name>A0A075A397_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162304.1">
        <property type="nucleotide sequence ID" value="XM_009164040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A397"/>
    <dbReference type="STRING" id="6198.A0A075A397"/>
    <dbReference type="GeneID" id="20314483"/>
    <dbReference type="KEGG" id="ovi:T265_00295"/>
    <dbReference type="CTD" id="20314483"/>
    <dbReference type="OrthoDB" id="6154955at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705428" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="88"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="223" mass="23948" checksum="E11EDCF63CEF1B6A" modified="2014-10-01" version="1">MQLVTVVWLFAFLHCWTRLGGVAQTSDTSCHLQLECTGTTETGPGRVRIPVRSARGPIGPTGERGLTGPPGPQGPAGLVTSSRTVGIPSEYQIAFYAGLTESIEAKPTTKDCPLIFDAVVLNLGGGYNATAGQFTAPVAGVYVFVLVLSAQSYEKAGAKLIHNGTPVLLSWCESTFWATVTNQVILKLDKGDKVWLQCREEAYRLHGHMYSNLSGYLIYPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3B4</accession>
    <name>A0A075A3B4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162317.1">
        <property type="nucleotide sequence ID" value="XM_009164053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3B4"/>
    <dbReference type="GeneID" id="20314496"/>
    <dbReference type="KEGG" id="ovi:T265_00308"/>
    <dbReference type="CTD" id="20314496"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="29554" checksum="15A2E11344FEDA0D" modified="2014-10-01" version="1">MHPCYWRGGGYTNAPWCNVTERPSLQGVPIHHTRFSSFVHATRSARWKTIQAVIQNSSVQKVDVKARCTVGQIFNIPHRPRLYWGSASWSHPPLSRRNNEQLLTDLVSSTRSPILCVGARRGPSKDPGGNVLHTGKPFTQESDIYSLTRISPKPLLRGKHAHTLPSSVRWTGTGVECHVMHYDRGPVNIVRIDAGEKSGIRARVSSRKSFAILRMIRRTFSRITRMDFQILYGAYVRPLLEYANQVVYSGRTKDVTPIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A451</accession>
    <name>A0A075A451_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165880.1">
        <property type="nucleotide sequence ID" value="XM_009167616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A451"/>
    <dbReference type="GeneID" id="20317384"/>
    <dbReference type="KEGG" id="ovi:T265_03197"/>
    <dbReference type="CTD" id="20317384"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13492" checksum="5D6CC561A355BB49" modified="2014-10-01" version="1">MSTGDRGNVILEQPRASGNSYRAWNDGLWDCGNNYTNCFLTAFCYTCMTCHLYGKYGEGCLTPCIVPMSAMVLTVQHRNRNGIRGNILEDCLTHAFCSPCAICRLYRDMQFVEEIKGSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4K5</accession>
    <name>A0A075A4K5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596904">
        <property type="protein sequence ID" value="KER22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173907.1">
        <property type="nucleotide sequence ID" value="XM_009175643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4K5"/>
    <dbReference type="GeneID" id="20329045"/>
    <dbReference type="KEGG" id="ovi:T265_14879"/>
    <dbReference type="CTD" id="20329045"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33253" checksum="CEBCA8E03A5DCA91" modified="2014-10-01" version="1" fragment="single">SIFDRYKITRQNAFAFYNPEPEDNLIFLDVLGEMAQVWFESDLRHSIPPSRLGQLGSIPALVLPSGGMEARHRKGATAERLDVLATDANRNLLWNYLKNELKQMKSWYFLIRELLTTTTTPKSSVNETAAAAITVRRIRVRRGDALVPVCGMLRTQILWRLIGGMNAQVGRLIVDEARLGGHLGLEVRRWTTANICSSYVLTTCCWCGVLTFESTKAAWSHGASRTRANFQNRTLQRRVRCAHLTWTLRSSLVVLRKKPTKYTHTKYTYSCLGMGTLTVSQPTYNHELRTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4M4</accession>
    <name>A0A075A4M4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_12663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163109.1">
        <property type="nucleotide sequence ID" value="XM_009164845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4M4"/>
    <dbReference type="GeneID" id="20326831"/>
    <dbReference type="KEGG" id="ovi:T265_12663"/>
    <dbReference type="CTD" id="20326831"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="770"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="909"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117089" checksum="17A1BB6179B141DC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Y4</accession>
    <name>A0A075A4Y4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165628.1">
        <property type="nucleotide sequence ID" value="XM_009167364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Y4"/>
    <dbReference type="GeneID" id="20317173"/>
    <dbReference type="KEGG" id="ovi:T265_02985"/>
    <dbReference type="CTD" id="20317173"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="19026" checksum="3D5C9672FC58A945" modified="2014-10-01" version="1">MKSKLEGTGRGLPRSSYQPQEKTSHLLSGNSKAGFTLGHIMNKSGQLSSTVVNRGTKRPSYGDGHHYDHQPHNHCLFTVTCTYIYSNMRCVAAAASELIYDMRFKTISGAQITEWNKDGTGERRNLQLNAAAASPSSSSSSAAAAAAASSASISETAHALVSAAAVAFADDMENERVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Z5</accession>
    <name>A0A075A4Z5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596895">
        <property type="protein sequence ID" value="KER22499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173756.1">
        <property type="nucleotide sequence ID" value="XM_009175492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Z5"/>
    <dbReference type="GeneID" id="20329002"/>
    <dbReference type="KEGG" id="ovi:T265_14836"/>
    <dbReference type="CTD" id="20329002"/>
    <dbReference type="OrthoDB" id="10422912at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="296"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="520" mass="58871" checksum="0941DC2368781DC5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6M1</accession>
    <name>A0A075A6M1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00211</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162183.1">
        <property type="nucleotide sequence ID" value="XM_009163919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6M1"/>
    <dbReference type="STRING" id="6198.A0A075A6M1"/>
    <dbReference type="GeneID" id="20314399"/>
    <dbReference type="KEGG" id="ovi:T265_00211"/>
    <dbReference type="CTD" id="20314399"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000359">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="603" mass="69453" checksum="0F089188C9CA9CB8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6Z4</accession>
    <name>A0A075A6Z4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Organic solute transporter Ostalpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173092.1">
        <property type="nucleotide sequence ID" value="XM_009174828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6Z4"/>
    <dbReference type="STRING" id="6198.A0A075A6Z4"/>
    <dbReference type="GeneID" id="20323079"/>
    <dbReference type="KEGG" id="ovi:T265_08900"/>
    <dbReference type="CTD" id="20323079"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49111" checksum="C68013B7931825F7" modified="2014-10-01" version="1">MMNELSQLWPAPETIPTRSKVQLEYLSKNVSNGTYDNASRRVSDDFLFLETTGAQVFAGLIAFSAILVTCHQIYLHLRHYTCPNEQRWVVRILFYVPIYAFESWISLLFLKHEDYYVYFDSVRDCYEAFVIYSFLSLCYEYLGGESCIMAEIRGKELPRSWAFCTCCFYGRTYTIEFLRFCKQATLQFCLIRPLTSIITIILQAAGVYKHGIFSVTNGYLYVTVIYNASAFVALYALVLFFLATRDILQPFDPVIKFAAVKSVVFLCFWQGVILAILEKFEVIPALPNTNAGTVAAGIQNFLICIEMFAASVVFRFAFPSELYSSGLASSDLGYDSLKGGFQSENGGDKGRLLSSSSGSLRSLRDTVNPRDMFHDAIHNFHPNYQKYTQQRNPKDEDEGEKFMRVQNSGPNLHKPENHIAPSTVPAPPIPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A776</accession>
    <name>A0A075A776_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172944.1">
        <property type="nucleotide sequence ID" value="XM_009174680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A776"/>
    <dbReference type="GeneID" id="20322959"/>
    <dbReference type="KEGG" id="ovi:T265_08780"/>
    <dbReference type="CTD" id="20322959"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14344" checksum="4B83F26F6B816A71" modified="2014-10-01" version="1">MEQVSAPSLHPAAEIVQTFAHPVERLQLSADISAQFPQTCAPGCGTSAEMEQVSAPSLHPAAEIVQTFAHPGKTIASELWSHIRINRTTLESALDSKSLGSVYSPARNQIESQNLDNTGHQQTDPLVYLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7Q1</accession>
    <name>A0A075A7Q1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596847">
        <property type="protein sequence ID" value="KER23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172752.1">
        <property type="nucleotide sequence ID" value="XM_009174488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7Q1"/>
    <dbReference type="GeneID" id="20322805"/>
    <dbReference type="KEGG" id="ovi:T265_08626"/>
    <dbReference type="CTD" id="20322805"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="318" mass="36306" checksum="0C567C80BECB45DC" modified="2014-10-01" version="1">MYVSTAVHLGSYKQVFQVLLDTNSDISWVPSTETTERTLQRKTQYKKGTSKEYSAHPQPLLIDDDFQSVSGDIAFDRFQVSELIDRPLTKPFQIAGVCMNEFKFGIVTKTKVDPKLPNGVDGVLGLSRKVTYHQFGRTLLESMYEELGIKEEIFALTLCPNDNPELATGHMTFGGLCRDCHKTEFSDFRATTPERWCITFERAAELRRLQVFDNRCHGTIGRVGWCWRTRNEAIRKRILSCATGTSIEECIQHQNLRWLGRAAHAEPSLTDKSAVFRAQLRVAEAKRQPTLDLEEKYEGDYEMFGCCRCYSLSRMGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8X6</accession>
    <name>A0A075A8X6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172277.1">
        <property type="nucleotide sequence ID" value="XM_009174013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8X6"/>
    <dbReference type="GeneID" id="20322444"/>
    <dbReference type="KEGG" id="ovi:T265_08265"/>
    <dbReference type="CTD" id="20322444"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28568" checksum="B0C8C1D9CBF97A2F" modified="2014-10-01" version="1">MEGLQTPGVQMACDEKLVDLEYADDIVLIFGENAQVFLDELIKVIPLVSSFGMHFTPTKCKVMFGDVRSLNTPLTIQGEVLEVVERFTCLGSCISSDCSVTDEQTHPDSADSLRVKHHFGTHTYILEAALSRKVACLWTSIPRTAVTPFWWCLAAMSPEGSTRAGILSGCPSLDRGIREAEVGFEPRTCRSVNSRSDHLGHLASEQLANSGLVFQKETECAAPGRLMIQLIRYLRYHDRLWDDQVEHKVDGNPGTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9D4</accession>
    <name>A0A075A9D4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163895.1">
        <property type="nucleotide sequence ID" value="XM_009165631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9D4"/>
    <dbReference type="STRING" id="6198.A0A075A9D4"/>
    <dbReference type="GeneID" id="20315760"/>
    <dbReference type="KEGG" id="ovi:T265_01572"/>
    <dbReference type="CTD" id="20315760"/>
    <dbReference type="OrthoDB" id="10055550at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20577" checksum="F0CA968FBDF1DA64" modified="2014-10-01" version="1">MSIQVVFLMSTALFFVTPMFVITIMYSRIAIQIRRSNFIQLLAQSTNNASEPVKFTTQGQTAARNRKGITRMLACTTNPFLTKKTNLTDNCLLSAIFLFRLFAGFLYYISPTVNPILYSLMSVRFRRAFLAVFCTKKHTRQPRRQPTLKNTCINVSYAPRCEHSQASSSQRHERFISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACK8</accession>
    <name>A0A075ACK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162594.1">
        <property type="nucleotide sequence ID" value="XM_009164330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACK8"/>
    <dbReference type="GeneID" id="20314714"/>
    <dbReference type="KEGG" id="ovi:T265_00526"/>
    <dbReference type="CTD" id="20314714"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7458" checksum="6342467FA53C3EF3" modified="2014-10-01" version="1">MHSQAGVDVHENRINYAYRYIDNNKNKKAVSCKGTSRCALRKTGGRGYRKRETAGNEAGSIANWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADI1</accession>
    <name>A0A075ADI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit f, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06605</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase F chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170173.1">
        <property type="nucleotide sequence ID" value="XM_009171909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADI1"/>
    <dbReference type="STRING" id="6198.A0A075ADI1"/>
    <dbReference type="GeneID" id="20320784"/>
    <dbReference type="KEGG" id="ovi:T265_06605"/>
    <dbReference type="CTD" id="20320784"/>
    <dbReference type="OrthoDB" id="8921675at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019344">
        <property type="entry name" value="F1F0-ATPsyn_F_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10206">
        <property type="entry name" value="WRW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57943" checksum="33765989ABBCB6C6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADK7</accession>
    <name>A0A075ADK7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_00132</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162053.1">
        <property type="nucleotide sequence ID" value="XM_009163789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADK7"/>
    <dbReference type="STRING" id="6198.A0A075ADK7"/>
    <dbReference type="GeneID" id="20314320"/>
    <dbReference type="KEGG" id="ovi:T265_00132"/>
    <dbReference type="CTD" id="20314320"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="217"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="838"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126584" checksum="6A97A2754B1046D0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADM7</accession>
    <name>A0A075ADM7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum lectin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ER lectin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162092.1">
        <property type="nucleotide sequence ID" value="XM_009163828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADM7"/>
    <dbReference type="STRING" id="6198.A0A075ADM7"/>
    <dbReference type="GeneID" id="20314359"/>
    <dbReference type="KEGG" id="ovi:T265_00171"/>
    <dbReference type="CTD" id="20314359"/>
    <dbReference type="OrthoDB" id="239053at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704609" description="Endoplasmic reticulum lectin 1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="94"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="505" mass="57243" checksum="BDE0E195CED0D485" modified="2014-10-01" version="1">MYTFGCIFTILLLCRFGLSSYEISDEILYKVRWSFSKDGSEDRPLSQNILISTSAGEKFECLVPIAQEFPEVNQLDSNATANEEVLLEQLFEARPCSTRAEFYWSYELCHKNYVRQFHEELLPDKITKSSKTQEYFLGYHKKGMYLLFVERFRILEISAGSPHSASRPGILLGGSSYPYYVVKFVDGTPCDLTGERRLTSVLYICLEDEDGRIIQVSEVESCQYQVVFATRYLCSHPAYRLPKRPVKPLSCAPREGAVAKPVSLMEFEKQQEQLSQHGISNLAALFGNVALKNIRVEANRRNNLIVYRIRTIDTDESNETDEDTMSQEDTSSSDGDSANRGDTGKAAEPTSKPTMPGSAYRTRFLEFISGKFCLQGRAAGWWQYEICLRSNVTQYHVNNQGKRAQVIVLGQWDPAAHERWSTKQAQNSISHVRSSAEGVNLFYGNGEFCELIGQVRETVVKLRCNTAANGIHLSFTERTDCRYTVLVESSAFCELTTDEIKSLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGF1</accession>
    <name>A0A075AGF1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B14.5a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_04596</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167635.1">
        <property type="nucleotide sequence ID" value="XM_009169371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGF1"/>
    <dbReference type="STRING" id="6198.A0A075AGF1"/>
    <dbReference type="GeneID" id="20318778"/>
    <dbReference type="KEGG" id="ovi:T265_04596"/>
    <dbReference type="CTD" id="20318778"/>
    <dbReference type="OrthoDB" id="10063829at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12485">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12984" checksum="15B2E86F5EEAF7B5" modified="2014-10-01" version="1">MSVRGGDRLTPLMARIRDFLLQRKYNNSLRYTENYSKRTQPPPFLPDGCSHDIAENAYYLRDERRRVSPPVEVFISGPKRLAESGSSSLPQPTSTSVTTVPGVKFNWDKQLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH80</accession>
    <name>A0A075AH80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166775.1">
        <property type="nucleotide sequence ID" value="XM_009168511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH80"/>
    <dbReference type="STRING" id="6198.A0A075AH80"/>
    <dbReference type="GeneID" id="20318097"/>
    <dbReference type="KEGG" id="ovi:T265_03910"/>
    <dbReference type="CTD" id="20318097"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="33641" checksum="72A63B37288CE2A5" modified="2014-10-01" version="1">MGLKEVHGCAHLLRESLRWWSSALSLLIPYLFLGLLCVLPFIVYQAYGYHLFCSPLGSTLPALLPEPAVFVIEHGIQMGYRLPYHLVSQYPQLKRNHTTPVWCSSDLPFSYSHIQREFWSVGFLGYFHWKQLPNFLLAIPVILLSLSCASSFYSRAPKAYRTLGVHAESARDRQLVPYVLHLLFLTVYGVSHINVQVLTRLIFSSCPMIYWYCAYLVYDSPQWQLEPGAKSGTKSKKSAVKTPKSTWYCKTSEIWRMLNPLNCRTISQCVILAYFLGYTLLGTVLHSKFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHL0</accession>
    <name>A0A075AHL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166187.1">
        <property type="nucleotide sequence ID" value="XM_009167923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHL0"/>
    <dbReference type="GeneID" id="20317626"/>
    <dbReference type="KEGG" id="ovi:T265_03439"/>
    <dbReference type="CTD" id="20317626"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9784" checksum="01AD71B94A4DF678" modified="2014-10-01" version="1">MVQAALSLEMQYCSERGDGASGTQSRDTVLQKVNAAVKKGKLLGLKGVGTTSPIQEMQTTTERRPQNQPITDTKERQGDKASDEYKRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHV1</accession>
    <name>A0A075AHV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165664.1">
        <property type="nucleotide sequence ID" value="XM_009167400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHV1"/>
    <dbReference type="GeneID" id="20317198"/>
    <dbReference type="KEGG" id="ovi:T265_03010"/>
    <dbReference type="CTD" id="20317198"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="43735" checksum="D783D4E8D8FDCF93" modified="2014-10-01" version="1">MVSGRNNTPTIDELITLHKFRWLATKPAKLRKNGYANALCYKNESGYTEYKITNLNGFRQTVAGGLCRRVLEVNEAVHFASQLQFATGSITGPVISRLHIWLTDSLPRSFTEQRDIGASIKLQPNWDVVDTNRHELPSASKINFECCRHRVGPRFVGCTVVCGWLQSLRSTQIFFVAATTAPGTFVTPEPAITSKMPLTAMPATRGRLTLSSIGLLVGFPGHALRSRGSLGRMKFVNRSCSGVPSFRSNSLTFHPSSNLEKSVLNMSSYRLNQESKVVHVKTNTKGAQRSINAQNEIRNSCTALRIYSVSGYNFLEFLTRSGAPLATGIWPILGHDWLSRLDAGPARVPNFGPTSSGPGFSAVAAPKACGILRMPVNRLPRRAVFAQPCEGWKRARDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHZ5</accession>
    <name>A0A075AHZ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165532.1">
        <property type="nucleotide sequence ID" value="XM_009167268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHZ5"/>
    <dbReference type="GeneID" id="20327283"/>
    <dbReference type="KEGG" id="ovi:T265_13115"/>
    <dbReference type="CTD" id="20327283"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15608" checksum="422F6267B620F7C7" modified="2014-10-01" version="1">MQYEFGGFTHTDLLKKQCKMGKYWHTVSQSYDSFTPVCCSLCTLPSATTLNSLKFVFKPQQRVYLVAFNAHTLKQAAQQVALVHTDGCYFHKIQDSTTMTAPSLSSRYQLRTCGDAKYAVAGYTGVGIVLSDREEASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI42</accession>
    <name>A0A075AI42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="1">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="1"/>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER30979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165279.1">
        <property type="nucleotide sequence ID" value="XM_009167015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI42"/>
    <dbReference type="STRING" id="6198.A0A075AI42"/>
    <dbReference type="GeneID" id="20327231"/>
    <dbReference type="KEGG" id="ovi:T265_13063"/>
    <dbReference type="CTD" id="20327231"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Methyltransferase TRM13" evidence="3">
        <location>
            <begin position="147"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="48150" checksum="7337781B4483990E" modified="2014-10-01" version="1" fragment="single">LDKHLSVCPNNPLFHETPTRINSANHQGSASSSSQLPPINTITQEVILFLEKLRFLKEKLKLDECEHLTTSRNFERAIDIALENPRHWSVNGFPGRLVCTVKPSLTTESTSPSIDAGQEAIPPSAGNREGSRTSIPDSRGTKRHIYQNGCLVNILRSQNILSTDFNYVEFGAGRGGLSHWVNLCLAFDDAELPDVLVNEHYWPNHPVDTNFILVEQNSIRYKFDTRHRDVGNFIRLRMDIAHLDLKSVPALSKTKHKPIVALAKHLCGDATDLALRCLRNASKSVDDEERSLSIGGALFAVCCHHQCSWEETVGRMWLENEAGLTAREFAIAARLSSWATCGFKRCRQSTNPEDDDGHSKQPNTSDLYELAGLTNEERISIGHTCKRLINWGRLCFIKNELKFPEAAMCTYTTVDVTPENLVLVASSSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN5</accession>
    <name>A0A075AIN5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164269.1">
        <property type="nucleotide sequence ID" value="XM_009166005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN5"/>
    <dbReference type="GeneID" id="20316067"/>
    <dbReference type="KEGG" id="ovi:T265_01879"/>
    <dbReference type="CTD" id="20316067"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="23017" checksum="77C599DD413998FD" modified="2014-10-01" version="1">MGEHEAFYGEQGFGRTFADRTAVGTRPNNDNCSGNVFSVSDLPCLRVGTSGDLGISDVFREISFSSAIPVSGTLSTDPVSWVSGLSFDFIDSVPPEVADAVPEYAHLPDLRFSSCDFVYDQEMFDSEISEMLRDNVEPEIVTHRTFFDDGDQLYLSEQLVLARDSMTGANTLPVVNVEGFGQDRLVEDILDIPVVDSKTDNDATYGHANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIW9</accession>
    <name>A0A075AIW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163910.1">
        <property type="nucleotide sequence ID" value="XM_009165646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIW9"/>
    <dbReference type="STRING" id="6198.A0A075AIW9"/>
    <dbReference type="GeneID" id="20315775"/>
    <dbReference type="KEGG" id="ovi:T265_01587"/>
    <dbReference type="CTD" id="20315775"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23103" checksum="36688B5CCDBDC2D3" modified="2014-10-01" version="1">MAAAVVKQCQEESTEDTPYELHPLQDSWSYYVYLYKSNGLWDECLNKVSTFSTIEQFWGVMLHTIPPSTHAYGTDVYMFRSDIQPSWEDPKNESGGRWLLNLSPTSPVDTYWEELLILLIGCDWETDEQAEQICGAVFQPRARGHKMAVWLSNGEDKDSILQIGTRIKERLNFPDQIYFQTVTEQKSLGRGKDITSGTYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJH7</accession>
    <name>A0A075AJH7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162830.1">
        <property type="nucleotide sequence ID" value="XM_009164566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJH7"/>
    <dbReference type="STRING" id="6198.A0A075AJH7"/>
    <dbReference type="GeneID" id="20314905"/>
    <dbReference type="KEGG" id="ovi:T265_00717"/>
    <dbReference type="CTD" id="20314905"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="12366" checksum="C2064B1C8F5B2E9B" modified="2014-10-01" version="1">MNAGAPLPAKVYPNATRPNLSITLATSLSSSQRHAQVKNGDPCSGLRPSAHPGESGSIDSPPSFGWPNSVRITNDVCGQFGQVNQIPEVEVAKSQQPALFAALPCSEHLLTTNPGHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTJ9</accession>
    <name>A0A074YTJ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL613963">
        <property type="protein sequence ID" value="KER18058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178195.1">
        <property type="nucleotide sequence ID" value="XM_009179931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTJ9"/>
    <dbReference type="GeneID" id="20330490"/>
    <dbReference type="KEGG" id="ovi:T265_16325"/>
    <dbReference type="CTD" id="20330490"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7189" checksum="49269A47393CC4C4" modified="2014-10-01" version="1" fragment="single">MISASKAEKSFYYQLNPVSTLPYLKQSVTDFCLLQGSARQLRPTLEVVIKDERQDRNVLSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUR8</accession>
    <name>A0A074YUR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600179">
        <property type="protein sequence ID" value="KER18526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177727.1">
        <property type="nucleotide sequence ID" value="XM_009179463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUR8"/>
    <dbReference type="GeneID" id="20326409"/>
    <dbReference type="KEGG" id="ovi:T265_12241"/>
    <dbReference type="CTD" id="20326409"/>
    <dbReference type="OrthoDB" id="6282927at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="414" mass="47080" checksum="296F4177646EA485" modified="2014-10-01" version="1">MIDVLQTRRRNYPRVTPAPPTQPPTQIEPPPTIKPEPPTRPPTTTTIKPDEEETKPTTATTTATTTTVATKKDEDEPETVSIMETKRQRLDAQEDESYGSNLAVAKLAQPLFGIHYYKTDITVTRKQHLTLAQYKPADTGITQYYVTCIPYQIFEFWTVNKGGDNFRDPLANLVKVYDYIHYNSGSIRFSHFVPLQQSLSSTTQQDTPALNTTPYAYIAKDSLGNLDGITSPTAIDITTMVNQQIKLPSNTYWSKDSDEGLLGLADVKTFHQGETVHYNFKFDNQMNCLKQKTPRWDNTFGHYFPLASGKPLKTGIAMSVQVNADESINQFKIPEYDLPFLFIFLPYIEQVNNTETIARLYAHVLMETELNFTLWTVPDGAKHLTGNMHNKNQLEPVLHKWTNKTLTQQAYQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUS2</accession>
    <name>A0A074YUS2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601146">
        <property type="protein sequence ID" value="KER18453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177800.1">
        <property type="nucleotide sequence ID" value="XM_009179536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUS2"/>
    <dbReference type="GeneID" id="20330210"/>
    <dbReference type="KEGG" id="ovi:T265_16045"/>
    <dbReference type="CTD" id="20330210"/>
    <dbReference type="OrthoDB" id="6262341at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="22098" checksum="75D1630CB67AAB6E" modified="2014-10-01" version="1" fragment="single">VECVSNLWSEQDPEDEFSPSSSETTLPSHSSGSHGLSVQSGSTTYGTTPASRWQSAEISKSPSAASLSMEASPSMSVFTTPQQQRPTKQPSLVTSSVVSSSGTGVSYIHSGPRSSLAGFQSVKNFPVVTRSVSIIQTSNVSRSVVPMSVVLSPTSPALLNTQSAIRGARTVQSPQTTASLRFTGPSSGQRIVIQPPSGNARSLLVQSSENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVL1</accession>
    <name>A0A074YVL1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598652">
        <property type="protein sequence ID" value="KER18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177560.1">
        <property type="nucleotide sequence ID" value="XM_009179296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVL1"/>
    <dbReference type="GeneID" id="20330052"/>
    <dbReference type="KEGG" id="ovi:T265_15887"/>
    <dbReference type="CTD" id="20330052"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6489" checksum="F41EFD8FA290111F" modified="2014-10-01" version="1" fragment="single">EPGKCSFTGSADDRNILTQWVCEIAANGQSFLTPNEMKTSTALELPETRISIDNAEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWQ8</accession>
    <name>A0A074YWQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597330">
        <property type="protein sequence ID" value="KER19108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177148.1">
        <property type="nucleotide sequence ID" value="XM_009178884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWQ8"/>
    <dbReference type="STRING" id="6198.A0A074YWQ8"/>
    <dbReference type="GeneID" id="20329823"/>
    <dbReference type="KEGG" id="ovi:T265_15658"/>
    <dbReference type="CTD" id="20329823"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13453" checksum="7234C06A20106E8E" modified="2014-10-01" version="1" fragment="single">MIHTDQSNCKVFQCFYGGSIEVDKATGVDQVNKAVEIGLSRLPMSQWSQAEVHIQPSCLQITLKRGPTIECRIRFLSFCSIFKTDARLCGLIQQSVTGTFACHVLKREPDATALCEAIKAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY10</accession>
    <name>A0A074YY10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Desmoplakin SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597178">
        <property type="protein sequence ID" value="KER19558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176691.1">
        <property type="nucleotide sequence ID" value="XM_009178427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY10"/>
    <dbReference type="STRING" id="6198.A0A074YY10"/>
    <dbReference type="GeneID" id="20325874"/>
    <dbReference type="KEGG" id="ovi:T265_11706"/>
    <dbReference type="CTD" id="20325874"/>
    <dbReference type="OrthoDB" id="6268792at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="104657" checksum="FE74BC1FB3020EA9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZU2</accession>
    <name>A0A074YZU2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597084">
        <property type="protein sequence ID" value="KER20168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176084.1">
        <property type="nucleotide sequence ID" value="XM_009177820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZU2"/>
    <dbReference type="STRING" id="6198.A0A074YZU2"/>
    <dbReference type="GeneID" id="20325388"/>
    <dbReference type="KEGG" id="ovi:T265_11220"/>
    <dbReference type="CTD" id="20325388"/>
    <dbReference type="OrthoDB" id="6287476at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="1">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="269" mass="30004" checksum="CE0C91C1B9691428" modified="2014-10-01" version="1">MSVNTGEEFVVRRSPVTFLALLTQNLSEARNNDIVDLLMCGDLTHTIPEDVRLGILLAILQLFQKNKVSRLTFPESFNSTQRGFVRLVSQMVGLRTFTSGNGPMKTLTVYNPTTENSEARTIHLSLSLNSKRAIMHLLQSNPLSARERLELNPVNEAQHTFDKGNREERQRGTTGRLMGAVPQVPPVPIAQTVLVADGFHAEGTQPTICNYSAEIIRLLKHSQVLVVFGPPGCGKTTYLPQALRWLGHLLCMPNYRLPKRMLFSLSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0F5</accession>
    <name>A0A074Z0F5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597428">
        <property type="protein sequence ID" value="KER18957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177295.1">
        <property type="nucleotide sequence ID" value="XM_009179031.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z0F5"/>
    <dbReference type="GeneID" id="20326249"/>
    <dbReference type="KEGG" id="ovi:T265_12081"/>
    <dbReference type="CTD" id="20326249"/>
    <dbReference type="OrthoDB" id="6276451at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06094">
        <property type="entry name" value="RP_Saci_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000130">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon opus-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034132">
        <property type="entry name" value="RP_Saci-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34974" checksum="F8865E2A630D176D" modified="2014-10-01" version="1">MATQMCCTIKMKVVTLNTKLQTSTLFDKRRLFHITDRSNGLRFFVDTGAEVSVLAHKNPLPDSASFSSQAANGTRIATYGERSLTLDLGLRRAFKWIFILADVQKPIIGADFLTHYNLSVDVRHKRLLDTCRNDRFKFLSNXRFLFKFEKLQKRLLLTYLRTHIWDEPEEHTRTVSTGFSGARSPLEFLKAPSWDQCCFVSTSTTSQTFLRDQCILLADDLKSWSSDVSALQMDVDAARQWSLDWHLPLNDEKCVHMSFGGDSANAFVMHASILPRAENIKSSATPFFHLCLSGERQPLTDKNKTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2N1</accession>
    <name>A0A074Z2N1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597142">
        <property type="protein sequence ID" value="KER19767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176491.1">
        <property type="nucleotide sequence ID" value="XM_009178227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2N1"/>
    <dbReference type="GeneID" id="20325714"/>
    <dbReference type="KEGG" id="ovi:T265_11546"/>
    <dbReference type="CTD" id="20325714"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7318" checksum="39EA0C4C88449474" modified="2014-10-01" version="1">MQPSERKRITQRPKPRLLSDEPNEVPKDLDGDTPGRQGALWDYGNHHPNSGFQVNENFQLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2P1</accession>
    <name>A0A074Z2P1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596975">
        <property type="protein sequence ID" value="KER21331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174931.1">
        <property type="nucleotide sequence ID" value="XM_009176667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2P1"/>
    <dbReference type="STRING" id="6198.A0A074Z2P1"/>
    <dbReference type="GeneID" id="20324499"/>
    <dbReference type="KEGG" id="ovi:T265_10331"/>
    <dbReference type="CTD" id="20324499"/>
    <dbReference type="OrthoDB" id="425681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59358" checksum="BDE89D3B590D649F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z372</accession>
    <name>A0A074Z372_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597111">
        <property type="protein sequence ID" value="KER19972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176276.1">
        <property type="nucleotide sequence ID" value="XM_009178012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z372"/>
    <dbReference type="STRING" id="6198.A0A074Z372"/>
    <dbReference type="GeneID" id="20329583"/>
    <dbReference type="KEGG" id="ovi:T265_15418"/>
    <dbReference type="CTD" id="20329583"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="289" mass="32820" checksum="F7F011D827B1A004" modified="2014-10-01" version="1" fragment="single">MREVMRDGKPVKIFTGLVDQSAEHVGDQFVTFHMKLTYKHDLDYRALIKWALDRMKRQNRLRQIVSNDAIQHLGLDLAVAHMICNIGGRVKFVGSDKWFFRYANLRPELPTQYAGDLRLSAIDLSGSNVVFEGFELFPQLRELRQLRVRRCIYVDDFCMSRVGRIANLELLDVSECPRVTSKGLATLAQLKNLRHLLVHNNPTMEDKELVCLLLEEHLPKLFISGVNYLGELPEEARRRVVALIGSGSSDAVTVKHLSGDISTENPLTSAGEAKTDEEPKKFEYQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3L0</accession>
    <name>A0A074Z3L0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597092">
        <property type="protein sequence ID" value="KER20102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176151.1">
        <property type="nucleotide sequence ID" value="XM_009177887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3L0"/>
    <dbReference type="GeneID" id="20325443"/>
    <dbReference type="KEGG" id="ovi:T265_11275"/>
    <dbReference type="CTD" id="20325443"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18424" checksum="120DF3BD821DF8CB" modified="2014-10-01" version="1">MYRLTPYSPTPESKAPAETLLYGTPRSTFDLLKLLKDVASTNHKMVSYYNLKHGAQWRHFDIRQSVFVKNSHGDHVYWRHGKITRRIGNVIYDVHPPPPSERQAYFFKFCFTSVLSETEKPSDKPLLNAPQHLCILYSASEGLRSSGNPSPPDNSSSGELKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z409</accession>
    <name>A0A074Z409_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174469.1">
        <property type="nucleotide sequence ID" value="XM_009176205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z409"/>
    <dbReference type="GeneID" id="20324136"/>
    <dbReference type="KEGG" id="ovi:T265_09968"/>
    <dbReference type="CTD" id="20324136"/>
    <dbReference type="OrthoDB" id="6262347at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703771" evidence="3">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="411" mass="45160" checksum="0618730E352A5C64" modified="2014-10-01" version="1">MFTILYIAVYAIVYISQAASFLPVNPVQPLRQDRSNANARTPVVGDTRLPVPNDDHGNVSLRDSHQERRKDEFKMQSSRSLSNTGVQASSPNDQVSVSNVDITGNTTQETSLHEVEPQKIIQKLGAEPVEQPDEQIHAGSLGGKELVNQSVDNKPNAVQNQPLLQPSINNSDVGTQNIKPTPTKLPSGKNATSVTETGGSFKVLGVKPTWVPKEPVKNIEWKSGKHGESYQAPQLPEDSFTNDNLRGMTELSKASGNLETQVKQNPFTEKVLSSLGLAMEAAKAKQKSPANQMSDDNVREPGISDEDDVGGEPEKNNLKNLDVLNSQLSKLPKATIESVRRAEDDPEISQSVFNVPSVPIEYVLLSICVLCVIVLLLWKRCWYVICTVCCKRRQQPIGNVTGRYKVTYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4X9</accession>
    <name>A0A074Z4X9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07670</name>
        <name evidence="2" type="ORF">T265_12294</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL602312">
        <property type="protein sequence ID" value="KER18365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171507.1">
        <property type="nucleotide sequence ID" value="XM_009173243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177888.1">
        <property type="nucleotide sequence ID" value="XM_009179624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4X9"/>
    <dbReference type="GeneID" id="20321849"/>
    <dbReference type="GeneID" id="20326462"/>
    <dbReference type="KEGG" id="ovi:T265_07670"/>
    <dbReference type="KEGG" id="ovi:T265_12294"/>
    <dbReference type="CTD" id="20321849"/>
    <dbReference type="CTD" id="20326462"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="8698" checksum="12D52393C12A5758" modified="2014-10-01" version="1">MVDDHGREPDNHQGLVLESRDCSADAIGSQSAQQPNRFFTYSDSSGGQRDRASGPAVGGFRLLSSGDVPAVHSPQVTNLNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z629</accession>
    <name>A0A074Z629_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598724">
        <property type="protein sequence ID" value="KER18680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177573.1">
        <property type="nucleotide sequence ID" value="XM_009179309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z629"/>
    <dbReference type="GeneID" id="20330060"/>
    <dbReference type="KEGG" id="ovi:T265_15895"/>
    <dbReference type="CTD" id="20330060"/>
    <dbReference type="OrthoDB" id="6251461at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="533" mass="60387" checksum="715C0911EC4EA0AE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6G1</accession>
    <name>A0A074Z6G1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acyl-CoA dehydrogenase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175118.1">
        <property type="nucleotide sequence ID" value="XM_009176854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6G1"/>
    <dbReference type="STRING" id="6198.A0A074Z6G1"/>
    <dbReference type="GeneID" id="20324642"/>
    <dbReference type="KEGG" id="ovi:T265_10474"/>
    <dbReference type="CTD" id="20324642"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="159"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="259"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45759" checksum="DF989709720C1124" modified="2014-10-01" version="1">MSFHLWRTKHIHSFPQKIFRYLSKSHGEAVFRWQDALNLDDGLSEQEHIIRDQCRSFCQEKLFPRVLLANRLEVFDRHILKEFGELGLLGSFIPDYGCAGVSYVAYGLIAREVERVDSGYRSAFSVQSSLVMLPIWKFGSEDQKKTFLPGLASGELVGCFGLTEPNHGSDPASMETCAVYDANKKAFVISGSKTWITNAPIADVFIIWAKTLPENTIRGFILTREMPGKFSLRASSTGTIHMDEVVVPETNMLPGVKGLKGPFTCLNSARYGIAWGVLGAAEFCLDAAREYTLTRQQFGRPLAANQLVQVKLADIMTDVALGLQGCVQVGRLMDAGKATPEMVSLIKRNSTDKALTAARLARDMLGANGVSDEYHVIRHVMNLESVNTYEGTRDIHALILGRAITGIQAFTSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6M5</accession>
    <name>A0A074Z6M5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER18900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009179089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6M5"/>
    <dbReference type="GeneID" id="20326274"/>
    <dbReference type="KEGG" id="ovi:T265_12106"/>
    <dbReference type="CTD" id="20326274"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11452" checksum="D96C8B8133A7B00D" modified="2014-10-01" version="1">MDERHRHPLNLESDTISCQFAENYAAAQVYRVAMLIPFISSAFTCQSAENYAAVQWPTEGQDGYGLLTATFDLRPDAIAHGQPLELTVAGHMSSEIRDMFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6T3</accession>
    <name>A0A074Z6T3_OPIVI</name>
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        <recommendedName>
            <fullName evidence="5">Disks large-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER22901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173363.1">
        <property type="nucleotide sequence ID" value="XM_009175099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6T3"/>
    <dbReference type="STRING" id="6198.A0A074Z6T3"/>
    <dbReference type="GeneID" id="20328923"/>
    <dbReference type="KEGG" id="ovi:T265_14757"/>
    <dbReference type="CTD" id="20328923"/>
    <dbReference type="OrthoDB" id="10023951at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF31">
        <property type="entry name" value="LD44824P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="101835" checksum="112AB39350CB6204" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7B4</accession>
    <name>A0A074Z7B4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596870">
        <property type="protein sequence ID" value="KER22993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173262.1">
        <property type="nucleotide sequence ID" value="XM_009174998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7B4"/>
    <dbReference type="GeneID" id="20323213"/>
    <dbReference type="KEGG" id="ovi:T265_09034"/>
    <dbReference type="CTD" id="20323213"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="676" mass="76735" checksum="ABC5A271C8235420" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z800</accession>
    <name>A0A074Z800_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_08836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173012.1">
        <property type="nucleotide sequence ID" value="XM_009174748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z800"/>
    <dbReference type="STRING" id="6198.A0A074Z800"/>
    <dbReference type="GeneID" id="20323015"/>
    <dbReference type="KEGG" id="ovi:T265_08836"/>
    <dbReference type="CTD" id="20323015"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27565" checksum="99A5E6240F7EC6A9" modified="2014-10-01" version="1">MPRNLVQVQLEKLLNLDARTKELIASIEKISSDAGDVKYFREQLDIYQDEVKSNISSMNAILDELQYGKASCFPYTKVSDLRQSISYNREQLSFLQDSYRKAIFKALRHLEGMEREHLIRRPLNPSGDLDVLNSAFETSVELTRDMTAHARRLAEEVKLGALNAEILEDSSSQITSNYAELREMSGQMGQSKRLTSLAYRRRLTSYVLYSLAFTFYFFSVAAIFLNRVPLGSWFLPSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z808</accession>
    <name>A0A074Z808_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_08845</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173021.1">
        <property type="nucleotide sequence ID" value="XM_009174757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z808"/>
    <dbReference type="STRING" id="6198.A0A074Z808"/>
    <dbReference type="GeneID" id="20323024"/>
    <dbReference type="KEGG" id="ovi:T265_08845"/>
    <dbReference type="CTD" id="20323024"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="233"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER23233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="436" mass="48428" checksum="5E7A645981D2BBCE" modified="2014-10-01" version="1">MGNACWELYCLEHGIQPDGQMPSDKSIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAVYPAPQIATAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYSPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEGEGEGEGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z858</accession>
    <name>A0A074Z858_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ets-domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596944">
        <property type="protein sequence ID" value="KER21737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174521.1">
        <property type="nucleotide sequence ID" value="XM_009176257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z858"/>
    <dbReference type="STRING" id="6198.A0A074Z858"/>
    <dbReference type="GeneID" id="20324180"/>
    <dbReference type="KEGG" id="ovi:T265_10012"/>
    <dbReference type="CTD" id="20324180"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000200">
        <property type="entry name" value="GA-binding protein alpha chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024668">
        <property type="entry name" value="GABP_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF195">
        <property type="entry name" value="GA-BINDING PROTEIN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1068" mass="116063" checksum="4FD955E84B116849" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8G6</accession>
    <name>A0A074Z8G6_OPIVI</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
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        <name evidence="15" type="ORF">T265_09902</name>
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    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3314" mass="367941" checksum="070520C731A1E18C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9M6</accession>
    <name>A0A074Z9M6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172435.1">
        <property type="nucleotide sequence ID" value="XM_009174171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9M6"/>
    <dbReference type="GeneID" id="20328722"/>
    <dbReference type="KEGG" id="ovi:T265_14556"/>
    <dbReference type="CTD" id="20328722"/>
    <dbReference type="OrthoDB" id="6226428at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="332" mass="38913" checksum="D5B5A4262421C345" modified="2014-10-01" version="1" fragment="single">MGTMPSRKSKSLIVNQQPPDSRYSLDQSVLRKSLDQKTKQQLFFECHVCILGRVALHRDEQFSQAKADVLMKRLHSKRQSHCIAYFLEDMIRFRKTKLLGSQPARNFVTYRAIKHVFLFEDKPDTFMLCIDNGRSIKKTYEAFKCKSREDVLAICEIIYKASLDSDYRLRDVTPIREFSRLSELSLPAHYHSTTELDRTERLARSTTSLVVDGPSQRVSDPVIDDYQPRRYDSTPLELYRVPVVKTSPKGYQKVYERKQTASPDARRKPYEWREAIDHLDNLNLAEKKEYSDDWEVNVTYLKWDNQFGAVVNDCGPIYMYFARRLNPHANYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBI9</accession>
    <name>A0A074ZBI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171768.1">
        <property type="nucleotide sequence ID" value="XM_009173504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBI9"/>
    <dbReference type="GeneID" id="20322043"/>
    <dbReference type="KEGG" id="ovi:T265_07864"/>
    <dbReference type="CTD" id="20322043"/>
    <dbReference type="OrthoDB" id="6252518at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="779" mass="86127" checksum="A2917C2640DE5CF7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBW1</accession>
    <name>A0A074ZBW1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171635.1">
        <property type="nucleotide sequence ID" value="XM_009173371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBW1"/>
    <dbReference type="STRING" id="6198.A0A074ZBW1"/>
    <dbReference type="GeneID" id="20321945"/>
    <dbReference type="KEGG" id="ovi:T265_07766"/>
    <dbReference type="CTD" id="20321945"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21588" checksum="B3AEAC3538906794" modified="2014-10-01" version="1">MTDKSGGTTSPKGILKKPKESQRQKTFQWDEMNILATYHPADKTYGHMKIEEPKTPFVFESESGVGGSYGAGFSAEDLAARLAAASHGTDEDQLPRAIRDPDPVDPAELEHQRQFREKRRLHYNEFMAAKMAQETLNPEETSSDDSELERAAEEAARNARLNAGKSRQVPLTDSSPANPNNRRGKQNDTTGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBY9</accession>
    <name>A0A074ZBY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173124.1">
        <property type="nucleotide sequence ID" value="XM_009174860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBY9"/>
    <dbReference type="GeneID" id="20323100"/>
    <dbReference type="KEGG" id="ovi:T265_08921"/>
    <dbReference type="CTD" id="20323100"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9759" checksum="96A2610D6F21788A" modified="2014-10-01" version="1">MAASLKLLGYFLRWALTFNDHRKTKRVEERQPRETSTTLKIPLRGHLDARLDCHVTAQLDDKVALVTHASPSSTNSTIKSNSDEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCU8</accession>
    <name>A0A074ZCU8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-activating enzyme E1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171156.1">
        <property type="nucleotide sequence ID" value="XM_009172892.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZCU8"/>
    <dbReference type="GeneID" id="20321567"/>
    <dbReference type="KEGG" id="ovi:T265_07388"/>
    <dbReference type="CTD" id="20321567"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF186">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1426" mass="157557" checksum="EA2C950EA7F2F52C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDM6</accession>
    <name>A0A074ZDM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172532.1">
        <property type="nucleotide sequence ID" value="XM_009174268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDM6"/>
    <dbReference type="STRING" id="6198.A0A074ZDM6"/>
    <dbReference type="GeneID" id="20328742"/>
    <dbReference type="KEGG" id="ovi:T265_14576"/>
    <dbReference type="CTD" id="20328742"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15390">
        <property type="entry name" value="7tmA_TACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="393" mass="45129" checksum="993841247200E330" modified="2014-10-01" version="1">MLCSPRKDILAYFVTNMEYNKGETSFVVFMFVILVLFSILGNFMVIYVILKCRGLRTVTNYFLFNLSAGDLLTLFQIVPNVHYVLTRDWIFGLSLCKLSQFFTVFNIAISVFTFVGITADRYTAIMFPLRPRIRPRTAIFYIFLIWLAAFVVGLPSLIFANVEATPVLLRGRSSVKKNETQGEQNVTYPNADTTVNTTQLEDTTRQCFLALNPKYDELYDYALFTLLYVLPLMVLAATYVPISLRLWFHRGIGEITRAQVESVRSKRRAVKMMCAMMCIFAICWFPYQVFFIILRVKPEFKRSPPAFAIFIACYWLAMSNAIYNPIIYFTMNRRFRNGLINALSCFSCSKPAPSQVELNIMKDAQLSYPDPQGHLGSSNTVEHYQYSVVTSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEB7</accession>
    <name>A0A074ZEB7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596958">
        <property type="protein sequence ID" value="KER21555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174702.1">
        <property type="nucleotide sequence ID" value="XM_009176438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEB7"/>
    <dbReference type="GeneID" id="20324319"/>
    <dbReference type="KEGG" id="ovi:T265_10151"/>
    <dbReference type="CTD" id="20324319"/>
    <dbReference type="OrthoDB" id="10363067at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="15522" checksum="5802ED8BF03237D1" modified="2014-10-01" version="1">MPTSKYSKFKKRFALYQSYPNMTYNLYLSCIVTVCFLILTCKTDPLGVEKEWGPNSYSAELEDADLEKRFLLSLPRPRQRRFFLGLPVMKNRARRVGKRTDEPDYDEYDAERGGPLSFRKRFLLGLGSRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEF0</accession>
    <name>A0A074ZEF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596825">
        <property type="protein sequence ID" value="KER24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172207.1">
        <property type="nucleotide sequence ID" value="XM_009173943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEF0"/>
    <dbReference type="STRING" id="6198.A0A074ZEF0"/>
    <dbReference type="GeneID" id="20322387"/>
    <dbReference type="KEGG" id="ovi:T265_08208"/>
    <dbReference type="CTD" id="20322387"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="20568" checksum="6D1AB8DD1B59802C" modified="2014-10-01" version="1">MIGPATNSTGPTLLPGAPSESGDPSTPSSDSPPTAASTAPPAATTVTAVSAATSTTEEEHTQLSSPFDLSVYLASSGAHRAPGTGSVVVSTNSPRVVPMSSVSDDPSMAAALTVVRLSRQQQRLLQSSLNSGATSTGLLFWNPQSPHQSNCSIPHGLNTQTSSVSSYSPASPTLPPGILFGTPILPVSLVRIAQSSAQGLQQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZET5</accession>
    <name>A0A074ZET5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170579.1">
        <property type="nucleotide sequence ID" value="XM_009172315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZET5"/>
    <dbReference type="GeneID" id="20321096"/>
    <dbReference type="KEGG" id="ovi:T265_06917"/>
    <dbReference type="CTD" id="20321096"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11453" checksum="909F3397F6CDD9E3" modified="2014-10-01" version="1">METGAGEGPGSDRRAMGDTPVLLEGWRAYERTMVQRNSATLQGVAPWCNVTVQPSLQGVPIASIATRSSMAKRYKIGRRDLLLCGSNLHHPTLRNFGFSRRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFA2</accession>
    <name>A0A074ZFA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_09868</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174337.1">
        <property type="nucleotide sequence ID" value="XM_009176073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFA2"/>
    <dbReference type="STRING" id="6198.A0A074ZFA2"/>
    <dbReference type="GeneID" id="20324036"/>
    <dbReference type="KEGG" id="ovi:T265_09868"/>
    <dbReference type="CTD" id="20324036"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="314"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="320"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER21915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="634" mass="70811" checksum="DF83F87AB16834FD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFF8</accession>
    <name>A0A074ZFF8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596759">
        <property type="protein sequence ID" value="KER26016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170249.1">
        <property type="nucleotide sequence ID" value="XM_009171985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFF8"/>
    <dbReference type="STRING" id="6198.A0A074ZFF8"/>
    <dbReference type="GeneID" id="20328256"/>
    <dbReference type="KEGG" id="ovi:T265_14090"/>
    <dbReference type="CTD" id="20328256"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="346" mass="39416" checksum="22F42062AE04F7BB" modified="2014-10-01" version="1" fragment="single">WHVLTKENIARVRKDEAQYEEEQRQIKYRAKLAEQESRTETLRKRGYRKLATSSGGPHGAILVASSTELIQGNKEYEAEKKSEKEKQEKAIGLLTYLGQSVLEAGGEKPWYDVPPKQLQSSTEKSRLKDEWEAKKKARADPLTEMNKITEWFEQRREEKAKEEAKVLQRANTCIAAMPSLFPNDIAVPKTLVTQGLLSGCRMVQNWYPRGPTDLSSAEKTHDNGQQKSKKKHSAVTEASCNSITESASENTVACTSDAIKLAKQAELDRLRAERLQRERKERERAALIMAKAMGLSEALQEPKQLETSVDERDLPFNSAFNPELSAALAERRRRHRESRKRQRSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFU6</accession>
    <name>A0A074ZFU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171742.1">
        <property type="nucleotide sequence ID" value="XM_009173478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFU6"/>
    <dbReference type="GeneID" id="20328570"/>
    <dbReference type="KEGG" id="ovi:T265_14404"/>
    <dbReference type="CTD" id="20328570"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="277" mass="30325" checksum="623278C13AE15A15" modified="2014-10-01" version="1" fragment="single">VSSNLRDSNGFVLIAGGLATRQTSDVDRSSQAGQLLDRRSMSRAPQSHRSSVNTFACSDVIIQMRPTASLWCELTGIITPEQEDERSNEDDVTKNKSEDKKATRRKCVLRQLQLSIYDSLDGRSTVNQPVCLLHAHTGSRTVVLLSRLITDGRLCACVRSWIGRVLSVSLFELSPAHGEIGRDSDVLDVCLGELRVQQLQTGPTTPFGFNVLVTFDNVYYESSGASAPVPTSTQERLVGFTCEECGKCCKSKAGFTQYDGHFVPDVRVLTVLAHTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIN2</accession>
    <name>A0A074ZIN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173056.1">
        <property type="nucleotide sequence ID" value="XM_009174792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIN2"/>
    <dbReference type="STRING" id="6198.A0A074ZIN2"/>
    <dbReference type="GeneID" id="20323049"/>
    <dbReference type="KEGG" id="ovi:T265_08870"/>
    <dbReference type="CTD" id="20323049"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="599" mass="65076" checksum="C23D9356B1C3F441" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJB2</accession>
    <name>A0A074ZJB2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169136.1">
        <property type="nucleotide sequence ID" value="XM_009170872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJB2"/>
    <dbReference type="GeneID" id="20319960"/>
    <dbReference type="KEGG" id="ovi:T265_05778"/>
    <dbReference type="CTD" id="20319960"/>
    <dbReference type="OrthoDB" id="10549377at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12305" checksum="ABD829F0A6814AC8" modified="2014-10-01" version="1">MEEVSLWLGVSPWHGTNRFKYWQPDRKLALLESRTDVTAGPEHNLARRFIRSQVEVSVHADREAWWTQKAKEMGDPERSNPPFFDNLEFCVSEANTLQMNIESAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJE9</accession>
    <name>A0A074ZJE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168789.1">
        <property type="nucleotide sequence ID" value="XM_009170525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJE9"/>
    <dbReference type="STRING" id="6198.A0A074ZJE9"/>
    <dbReference type="GeneID" id="20319685"/>
    <dbReference type="KEGG" id="ovi:T265_05503"/>
    <dbReference type="CTD" id="20319685"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21447" checksum="97E690A68E68B723" modified="2014-10-01" version="1">MSKDENPDPIVVNRWHSTAVKNALDDATKALMSKEHGLVENHALFDGRLALCTLSVIVAAVALLWDYLYPHPQSRMVLVVCVIIYFILSGIITLYVLYVERNIFYVGKKMDPTGLDPPDTWQFSSHMEKYDPTYHLSLIVSYGKTNKSKVASLDRCVADFFDAKGTLRSDLYNAAVLKMIKELDSAKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJV6</accession>
    <name>A0A074ZJV6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168597.1">
        <property type="nucleotide sequence ID" value="XM_009170333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJV6"/>
    <dbReference type="GeneID" id="20319524"/>
    <dbReference type="KEGG" id="ovi:T265_05342"/>
    <dbReference type="CTD" id="20319524"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27391" checksum="1BC21ABD8901ECD1" modified="2014-10-01" version="1">MGTPSGYEGETADMDRTFGLTEALPETRLVNRKGDCARTKSIASVTVMRLDFDRSVCGEVEVDGMEYMSVASSDIGARWTKWLEREFTDRKVRGSNVTSASRLPLPRLGQPGSIPALVQPSGGMAVRHRKDATAERMQDTKTEIRLIDTRQIFKTASAVVQEIHIKINNESFNCNTLLVPSCYATRRRHEGWDTNRMPKPRQGKSIGRGRVRTTDPAVICHINQSMHAFSMASFRETWMVVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU7</accession>
    <name>A0A074ZLU7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171916.1">
        <property type="nucleotide sequence ID" value="XM_009173652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU7"/>
    <dbReference type="STRING" id="6198.A0A074ZLU7"/>
    <dbReference type="GeneID" id="20322154"/>
    <dbReference type="KEGG" id="ovi:T265_07975"/>
    <dbReference type="CTD" id="20322154"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="188" mass="20750" checksum="BC74A6C2A5F086BA" modified="2014-10-01" version="1">MSPALGKQSAAALSSRSSCPYFPDLFSPRRCELLRIQATVIDPDETVVPSVLVLDSTQGPELRPYRLTRYSAFTCDKKQQRFSITSREHPSMNPQAWYLRVVIAGRIVDTRCKLNTNRQMQINTGSAYASVTDVNTQFARPSLLASSSGLHLFASVHSDRKARRPGIEPRVCGQQANASPTTPTGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM31</accession>
    <name>A0A074ZM31_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167821.1">
        <property type="nucleotide sequence ID" value="XM_009169557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM31"/>
    <dbReference type="GeneID" id="20318926"/>
    <dbReference type="KEGG" id="ovi:T265_04744"/>
    <dbReference type="CTD" id="20318926"/>
    <dbReference type="OrthoDB" id="10581749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="16873" checksum="45ADF890A70D602F" modified="2014-10-01" version="1">MVQSENKQTHWLHCCWEVIKLSMAVPCHHWPDMLQSLDSHMTDVTFEMIRLGPVEETGRNETDMGLSLARWSRYQLTGSSKRALPKFKAWEDEVMEEIRRSQIKTWRQPGRGNKLVRNRYWIVGFLGPLGDPGVVDHWLGGVDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMF9</accession>
    <name>A0A074ZMF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_04863</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167981.1">
        <property type="nucleotide sequence ID" value="XM_009169717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMF9"/>
    <dbReference type="STRING" id="6198.A0A074ZMF9"/>
    <dbReference type="GeneID" id="20319045"/>
    <dbReference type="KEGG" id="ovi:T265_04863"/>
    <dbReference type="CTD" id="20319045"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="184"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="628" mass="72178" checksum="DC0943A0EBBCE51A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMM0</accession>
    <name>A0A074ZMM0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_07753</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="KL596803">
        <property type="protein sequence ID" value="KER24605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171622.1">
        <property type="nucleotide sequence ID" value="XM_009173358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMM0"/>
    <dbReference type="STRING" id="6198.A0A074ZMM0"/>
    <dbReference type="GeneID" id="20321932"/>
    <dbReference type="KEGG" id="ovi:T265_07753"/>
    <dbReference type="CTD" id="20321932"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="13">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="14">
        <location>
            <begin position="232"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER24605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="47744" checksum="881EA56E2C87D099" modified="2014-10-01" version="1">MRLMVFYCVAHGARMLLDDLITIPCFSELMIPSDAILEVPNFVHRRYDPLMGEWIIVSPHRISRPWSGQLEFPERTLSNKPEPKSVVINPLCPGATRSSGTINPNYSDTFLFPNDFPALDTTDESIEDDHLASKALSENPLFAWAPAHGDCQVMCFHPDSNKTLALMSPAEVRRVIDAWCDLTTKYQSQRRYRWLQIFENRGAAVGCSNMHPHCQVWACGFLPSIVKRRDYNQRAYFETHGSPLLLNYARQEERTFGQTLNRLVIASEDWLVLVPWWACWPFETILLPRKRHIRWLHELTDKEREGLVEIIQQLLTRYDNLFHTDFPYSMGWYQAPFCNVSETSTSDITDYPYWQLHAIYQPPLLRSATVRKFMSGFELLCEPQRDLLPEKAAELLRKTSAVHYTRCQAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNJ6</accession>
    <name>A0A074ZNJ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168918.1">
        <property type="nucleotide sequence ID" value="XM_009170654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNJ6"/>
    <dbReference type="GeneID" id="20319784"/>
    <dbReference type="KEGG" id="ovi:T265_05602"/>
    <dbReference type="CTD" id="20319784"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7689" checksum="720BF0E2DB8110D1" modified="2014-10-01" version="1">MSTPENHRGRPTHSGTRSGIDPTRWIMTHFAYALSENGLHQAGKLRAVQRRARAQLRLARQDRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPC7</accession>
    <name>A0A074ZPC7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168621.1">
        <property type="nucleotide sequence ID" value="XM_009170357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPC7"/>
    <dbReference type="STRING" id="6198.A0A074ZPC7"/>
    <dbReference type="GeneID" id="20319548"/>
    <dbReference type="KEGG" id="ovi:T265_05366"/>
    <dbReference type="CTD" id="20319548"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="20897" checksum="F81C4159335B25ED" modified="2014-10-01" version="1">MAVEPVVLSLRRPTSDKSWGFALEGGADQGLPVFVHKVTRNGIAHKSGLEPGDVIIRICATPVTGMTHAQVKAEILRAGNDLDFTVKKRDFNVVQYNITMQQFAAANKPSQAGPESQEPRVEIVEEHLWRHGGPTFKNVQPKSYKILEQQLPQSSVGGPPPPSVFERSIDERSPYLQATEPTIQKAYGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPZ8</accession>
    <name>A0A074ZPZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170852.1">
        <property type="nucleotide sequence ID" value="XM_009172588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPZ8"/>
    <dbReference type="GeneID" id="20321323"/>
    <dbReference type="KEGG" id="ovi:T265_07144"/>
    <dbReference type="CTD" id="20321323"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13274" checksum="1DC51285D08783E5" modified="2014-10-01" version="1">MASSIPVKSELYAALAAKFASRSAGAVKKRLIKMQWSGISKYKTGNGAKRRPKPLPKIPECAWSSDKEWTRPNPCRRPIWSSGDEKECPPSDVNTCIMDDEGVVDGRSVDDSDCADWRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ30</accession>
    <name>A0A074ZQ30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170827.1">
        <property type="nucleotide sequence ID" value="XM_009172563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ30"/>
    <dbReference type="GeneID" id="20321299"/>
    <dbReference type="KEGG" id="ovi:T265_07120"/>
    <dbReference type="CTD" id="20321299"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8834" checksum="41A917282E8B0EFF" modified="2014-10-01" version="1">MSKVVSNNGSDFQKQREKTAQLTCTLLMTLDNICTTSIEFPLELEKITVTLVKRISFDAQQPRNDERTAKMSLRRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZST3</accession>
    <name>A0A074ZST3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type I phosphodiesterase / nucleotide pyrophosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167347.1">
        <property type="nucleotide sequence ID" value="XM_009169083.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZST3"/>
    <dbReference type="GeneID" id="20318544"/>
    <dbReference type="KEGG" id="ovi:T265_04362"/>
    <dbReference type="CTD" id="20318544"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="285"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1480" mass="168607" checksum="C3A8D7BFEC3B0449" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSV1</accession>
    <name>A0A074ZSV1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBF1/SBF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166139.1">
        <property type="nucleotide sequence ID" value="XM_009167875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSV1"/>
    <dbReference type="STRING" id="6198.A0A074ZSV1"/>
    <dbReference type="GeneID" id="20317593"/>
    <dbReference type="KEGG" id="ovi:T265_03406"/>
    <dbReference type="CTD" id="20317593"/>
    <dbReference type="OrthoDB" id="6268344at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039872">
        <property type="entry name" value="KIAA0513"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBF1/SBF2" evidence="2">
        <location>
            <begin position="172"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="355" mass="40166" checksum="FDF1A05C84B65B00" modified="2014-10-01" version="1">MNVRGFFKNVLNSEQAQDTSAIPPDDPNSGTLGSGVSGFLSGTTRFLDTVQNKKNGLLNDLTTKFSGIKLPGDQSGGRTKRKKTSRVQENEGDEESSASEYGDEGDKPMYAEQAPLESQESVDSVDSLPEQEAEQCKAEIRTIISTILQQNAISPDLEANFQNYSMHHTGRSAFAKELKRQTNQTKELPASVLNQLGQYASHVLVHCNENDDFAPATQIMQRSFTLYHEVRALSMDEHGEQHYLFTLLRDQPIWQSMRFWNAAFFIALQTERRNQTIPAGLRDDETLLAEKEQQENAAFIQISKFVWRMHAFGIPRESCVEFLRKQANGENLSKDRCRILHTNLQKLYETEARPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTB2</accession>
    <name>A0A074ZTB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LICD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600577">
        <property type="protein sequence ID" value="KER18499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177754.1">
        <property type="nucleotide sequence ID" value="XM_009179490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTB2"/>
    <dbReference type="GeneID" id="20330181"/>
    <dbReference type="KEGG" id="ovi:T265_16016"/>
    <dbReference type="CTD" id="20330181"/>
    <dbReference type="OrthoDB" id="6358690at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF34">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40949" checksum="B2E032282841B06D" modified="2014-10-01" version="1" fragment="single">RNFTLRIQPGHDISSKSCAYCDYIASPFLIRRDLLQRLLEYRSELSGALTFVEMFLKQKQSPEYYTLQTMSCIDVLFHVAGESSGIRGQGVAEIPKHFWFNLAKHWTLDRVILPGQVDYKWTCQDLDISCRKYQNAGVILPRCCLEELSGCVKGFLNLASEYNISVFVFAGTLVGAVKTYGGFLPWERDADIVWDPFAYDHIRGPISKRLKDKFQCDLGPVRLETAYGDNVSACAQALNTSCLYYKLHSRSWNIDLWGDPHLEPYRLNGLINPTQVYLDGLWVSTVPNPGRVARHRYGDNVLGHVQHWQDYGLKTSWESYANFEKKAFLPCPARFVRHACLSGNYLPHGNIQFQDFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTF9</accession>
    <name>A0A074ZTF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165575.1">
        <property type="nucleotide sequence ID" value="XM_009167311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTF9"/>
    <dbReference type="STRING" id="6198.A0A074ZTF9"/>
    <dbReference type="GeneID" id="20317135"/>
    <dbReference type="KEGG" id="ovi:T265_02947"/>
    <dbReference type="CTD" id="20317135"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="201"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="602" mass="66292" checksum="D1ECA1FDE0F2523F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTJ7</accession>
    <name>A0A074ZTJ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165478.1">
        <property type="nucleotide sequence ID" value="XM_009167214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTJ7"/>
    <dbReference type="STRING" id="6198.A0A074ZTJ7"/>
    <dbReference type="GeneID" id="20327271"/>
    <dbReference type="KEGG" id="ovi:T265_13103"/>
    <dbReference type="CTD" id="20327271"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="443" mass="50276" checksum="F3AF6335C6EC6F1D" modified="2014-10-01" version="1" fragment="single">MGEAAGCFVSPSDFDVNRFIGRGCYSVVYEVAKRNGTDSGSRYALKRFFLENDSSVKCVLRERRILERLALADYESPFLPKLLYGLWCNYSSAFILREGAGCDLYDLLCHVGFLSETNARFYLTEVICGLEHLHSLNIVHLDIKPENVLFYPDGHVFLSDLDRSFDISLGMKPTLDDFTGTPLFMAPEIAKGEVIDLRADIWSLGALVAEMVAGPIRPDSHDTAHEFQRARSGTYTIRGLKRFSKPLQSFFTVCLQKNLNQRPHLKDVKKLRFLRYVDWEKANKLDLLPPYKTSEIHHRPAKEERGPLKSTDQRVLSGAFSPLRPVVFASNKAKKKQTELCAVPVDSFTEQRQSSALTDCLRKDGYTLELLNERFKCFNFVHPSLRYNYSTAKPESQSTKLTALSQDDLDTLFGDKLKIIGLEEPSSPSLFRRTRKRGLSIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU77</accession>
    <name>A0A074ZU77_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166833.1">
        <property type="nucleotide sequence ID" value="XM_009168569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU77"/>
    <dbReference type="STRING" id="6198.A0A074ZU77"/>
    <dbReference type="GeneID" id="20318148"/>
    <dbReference type="KEGG" id="ovi:T265_03962"/>
    <dbReference type="CTD" id="20318148"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="1">
        <location>
            <begin position="254"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="377" mass="41933" checksum="855F2217B9588E0D" modified="2014-10-01" version="1">MAFSMVCCTNTVVIVSEFSYAVHILHMALVGFVSQSSTNVQPTVYDSFIGGSLLAYPGHSPPPDQLILCKSCRHRMCFIAQIYCPLGGSSYHRSLYLFVCLKRSCQLDGFNWIALRSQSLDCEPARAELFEADWAFDDSGDENETKVDSSWNADTDSIPKTEKPLVSQRLLGPFLGSFLEVFDDVAANPVSDIIDDSPDQTGSHANISSICAWLCAEEVERAFVEEDDNTMEKAFSGALSSHLANRSEHGLEDVRYHWGGCPIFNGRPPRQLEQCLTCSRCHSPRVFEVQLFSVLNNSLKLDPGCRSDAAAAPLPYDLHEDEFNVDWPLKIITVIVFSCSSSCWSESDEWVEECVVVQTDTDRTCIVAETFTVHCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUK8</accession>
    <name>A0A074ZUK8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165126.1">
        <property type="nucleotide sequence ID" value="XM_009166862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUK8"/>
    <dbReference type="GeneID" id="20316771"/>
    <dbReference type="KEGG" id="ovi:T265_02583"/>
    <dbReference type="CTD" id="20316771"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9720" checksum="FB6081D8129FFB66" modified="2014-10-01" version="1">MVIARSTLIGKSSQAETLARQVTSAIAAHLFTINNQTDPAEDFSAIYRFLARPPRALRQRVPEITKAATVQSLDHSLCYRKWHAQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUM9</accession>
    <name>A0A074ZUM9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165475.1">
        <property type="nucleotide sequence ID" value="XM_009167211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUM9"/>
    <dbReference type="STRING" id="6198.A0A074ZUM9"/>
    <dbReference type="GeneID" id="20317055"/>
    <dbReference type="KEGG" id="ovi:T265_02867"/>
    <dbReference type="CTD" id="20317055"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005859">
        <property type="term" value="C:muscle myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF33">
        <property type="entry name" value="MYOSIN LIGHT CHAIN ALKALI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0518">Myosin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="33718" checksum="F85D28CDB8CE59DF" modified="2014-10-01" version="1">MSQPTQLLVPDIYFNGSTRCTTENSFPNCLVTDTPTPAHTNYGSETTIVEHMKTSQFRYPNKPNSKTAHTIRAFTSPVALQSELIQLPRYIKRFTTSNGVQHTPDIDVNGSKPLFPANVYYFGIIPSANQSIDCDSRGRSDKLCSSLSKAEVEDIREVFDLFDFWDGRDGMIDAVKVGDLLRCSGMNPTIAICVKHGATRKQGEKQYKFDEFLPCYEAILKENEGGTFADYMEAFKTFDREGQGFISAAEMRHVLTGYGEYLEDSDVDKIVKLIDLHEDLDGNIKYEELIKKVMQGPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVT8</accession>
    <name>A0A074ZVT8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597257">
        <property type="protein sequence ID" value="KER19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176964.1">
        <property type="nucleotide sequence ID" value="XM_009178700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVT8"/>
    <dbReference type="GeneID" id="20326054"/>
    <dbReference type="KEGG" id="ovi:T265_11886"/>
    <dbReference type="CTD" id="20326054"/>
    <dbReference type="OrthoDB" id="6253453at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19021" checksum="DEAC171501D62423" modified="2014-10-01" version="1">MRFYAFLLLLSFVCADPSTPEEGKEQENDEKKESTETDDFGGDVLSKGMELFANMVKDEKIGLGDALTLMSAFGNIKKAFEEGAKSVKNVEEETKPDKEPSLDDLVLRFKEFGEILMDEFGPYADTIFKAASTFEWKDLLISGLRSSRSLIDTVIDVLEKPSTDTSHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVZ9</accession>
    <name>A0A074ZVZ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_02140</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164578.1">
        <property type="nucleotide sequence ID" value="XM_009166314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVZ9"/>
    <dbReference type="STRING" id="6198.A0A074ZVZ9"/>
    <dbReference type="GeneID" id="20316328"/>
    <dbReference type="KEGG" id="ovi:T265_02140"/>
    <dbReference type="CTD" id="20316328"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="331"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER31628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="688" mass="77595" checksum="684835E9B1E13BA1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW01</accession>
    <name>A0A074ZW01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597232">
        <property type="protein sequence ID" value="KER19369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176884.1">
        <property type="nucleotide sequence ID" value="XM_009178620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW01"/>
    <dbReference type="GeneID" id="20326003"/>
    <dbReference type="KEGG" id="ovi:T265_11835"/>
    <dbReference type="CTD" id="20326003"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="18456" checksum="3867DE7A906AE013" modified="2014-10-01" version="1">MGRVCIKFLPSLTQTESPIWCGLTGIIALEQEDCPITSFPCLAVTPPEGNTRAEILSGCPKNNRGAESTSQRNNRRQYRIILDSERKRSAVALFRCLPAMPPEGSTRARILPGRPSLDRRSRVAEVGFEPRTFRSVNSRSSHLGRLAQEEELANYLKAQKSSPSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW43</accession>
    <name>A0A074ZW43_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZW43"/>
    <dbReference type="GeneID" id="20327105"/>
    <dbReference type="KEGG" id="ovi:T265_12937"/>
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    <dbReference type="OrthoDB" id="2115465at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23316">
        <property type="entry name" value="Ig_DLEC1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1486" mass="164773" checksum="79DE8F14FC8B1C97" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWF4</accession>
    <name>A0A074ZWF4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164481.1">
        <property type="nucleotide sequence ID" value="XM_009166217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWF4"/>
    <dbReference type="STRING" id="6198.A0A074ZWF4"/>
    <dbReference type="GeneID" id="20327077"/>
    <dbReference type="KEGG" id="ovi:T265_12909"/>
    <dbReference type="CTD" id="20327077"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="283" mass="32664" checksum="1CE57E261F663295" modified="2014-10-01" version="1" fragment="single">QLNVLYQAASCFSRYDNRDIAIHVYPSNALLISEKRICKQIWFCERLTWNIAQSIAYGVFKQLNVLHQAAPCFRRYDIRNITIRTCIPRVSVNLMFYLNTSCTNLAKYSCLHTNLVLMGDSPETQLNLTFMMFQVEGAGHSRKSATNCVNTRLLRICQQPTTGFALLAALRVTECAAPGRLMFQLIRCSMYRDKCESLTELNEFANECIFANFYNQFIKVFVRPAFAGGVAITCSSCKSEFRGGQCYAKPTSSDKTEIRVQRFHRVNQQEYYWRQDKKLFTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWZ9</accession>
    <name>A0A074ZWZ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AXH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009167476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWZ9"/>
    <dbReference type="STRING" id="6198.A0A074ZWZ9"/>
    <dbReference type="GeneID" id="20317258"/>
    <dbReference type="KEGG" id="ovi:T265_03071"/>
    <dbReference type="CTD" id="20317258"/>
    <dbReference type="OrthoDB" id="6244403at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043404">
        <property type="entry name" value="ATAXIN1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392">
        <property type="entry name" value="ATAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392:SF14">
        <property type="entry name" value="ATAXIN-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AXH" evidence="8">
        <location>
            <begin position="337"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="635" mass="71813" checksum="7BF5D033220C67BF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX88</accession>
    <name>A0A074ZX88_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168275.1">
        <property type="nucleotide sequence ID" value="XM_009170011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX88"/>
    <dbReference type="GeneID" id="20319276"/>
    <dbReference type="KEGG" id="ovi:T265_05094"/>
    <dbReference type="CTD" id="20319276"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7405" checksum="4F52CEDEF2C81DBA" modified="2014-10-01" version="1">MDNKIDEDLLLTAMQLILYVLNAVPVAKLGDVDQEDYEEIEKCMKNGNGVLQKKGQHQDVKSRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYM6</accession>
    <name>A0A074ZYM6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165093.1">
        <property type="nucleotide sequence ID" value="XM_009166829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYM6"/>
    <dbReference type="GeneID" id="20316738"/>
    <dbReference type="KEGG" id="ovi:T265_02550"/>
    <dbReference type="CTD" id="20316738"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15411" checksum="FA15EFB82817B7DF" modified="2014-10-01" version="1">MKLGDAINLPVHEGSTSYRSPACSTTLYAQDDRVYARYRAIQLHSNVTYCISSPDCQSNTGQRCCVQLNKFRGTPVISHHAGCRVPCSTKYPRNPFDHPKATSDEKSSPFRSNEPPAIYVHANCSAQRKYPSLSVSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYX7</accession>
    <name>A0A074ZYX7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165018.1">
        <property type="nucleotide sequence ID" value="XM_009166754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYX7"/>
    <dbReference type="GeneID" id="20316679"/>
    <dbReference type="KEGG" id="ovi:T265_02491"/>
    <dbReference type="CTD" id="20316679"/>
    <dbReference type="OrthoDB" id="6286799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8128" checksum="D57C9C04793CAC65" modified="2014-10-01" version="1">MPHRPSRGAISRVALLAAYSRAGYQGRLPPEHLPIERAVQPTAALDSTVTPHEVAVALLFVPGAASMLIWNLASSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ69</accession>
    <name>A0A074ZZ69_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10981</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="KL597052">
        <property type="protein sequence ID" value="KER20479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175774.1">
        <property type="nucleotide sequence ID" value="XM_009177510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ69"/>
    <dbReference type="STRING" id="6198.A0A074ZZ69"/>
    <dbReference type="GeneID" id="20325149"/>
    <dbReference type="KEGG" id="ovi:T265_10981"/>
    <dbReference type="CTD" id="20325149"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000961">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="73"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER20479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="552" mass="61010" checksum="3820C46F5DE039B2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0A7</accession>
    <name>A0A075A0A7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family. LRRC14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163505.1">
        <property type="nucleotide sequence ID" value="XM_009165241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0A7"/>
    <dbReference type="STRING" id="6198.A0A075A0A7"/>
    <dbReference type="GeneID" id="20315444"/>
    <dbReference type="KEGG" id="ovi:T265_01256"/>
    <dbReference type="CTD" id="20315444"/>
    <dbReference type="OrthoDB" id="6279874at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF37">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="800" mass="90062" checksum="B6AE8F86DEA36FE6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0R4</accession>
    <name>A0A075A0R4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597003">
        <property type="protein sequence ID" value="KER21004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175256.1">
        <property type="nucleotide sequence ID" value="XM_009176992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0R4"/>
    <dbReference type="GeneID" id="20329358"/>
    <dbReference type="KEGG" id="ovi:T265_15193"/>
    <dbReference type="CTD" id="20329358"/>
    <dbReference type="OrthoDB" id="6267571at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32048" checksum="222F4DEBDF682D0B" modified="2014-10-01" version="1" fragment="single">MVESKYQRNYFFAYFERLDRHVHASGEEQSLDFQPFGCCIMSSINTLEFLQVINKHEKYHQRTPNQVSRTFKSQFSTNLVSAPGLGLIFDVPSENARLPSLYSGSVPCQNSAVHWSGKGLRHHSSSQSTDSQSESDPECSEATALRESSFSETGKHSNSYVVHLPCFSPDITEAIKAYRLCLPPSSVLVAYVDHPRSAVIFLSDTEASSHMLQKRVLVACLEALEADGVARVYVAVRKSPNEVGTCATSALLKTLMFLGFEMFNPGSVSPELACLTIDYRLLFTNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0X1</accession>
    <name>A0A075A0X1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163303.1">
        <property type="nucleotide sequence ID" value="XM_009165039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0X1"/>
    <dbReference type="GeneID" id="20315284"/>
    <dbReference type="KEGG" id="ovi:T265_01096"/>
    <dbReference type="CTD" id="20315284"/>
    <dbReference type="OrthoDB" id="6251429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="627" mass="71611" checksum="71E97AFCBB3C68EB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A100</accession>
    <name>A0A075A100_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164262.1">
        <property type="nucleotide sequence ID" value="XM_009165998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A100"/>
    <dbReference type="STRING" id="6198.A0A075A100"/>
    <dbReference type="GeneID" id="20316060"/>
    <dbReference type="KEGG" id="ovi:T265_01872"/>
    <dbReference type="CTD" id="20316060"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="218" mass="25293" checksum="13B40913A5675D96" modified="2014-10-01" version="1">MPELRLGLNDKLRFENMGRGRGKAVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWVEAIIEKHAHSRMEYMVKAKAQFKRRSTANQVEIHVPVPSDVDSPRFKTTMGSAKYVPETNVVVWTIRSFPGGKEYILRASFGLPSVEREQEVESKPPISVRFEIPYFTVSGLQVQHLKIIEKTGYHALPWVRYITQNGDYQLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A132</accession>
    <name>A0A075A132_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162858.1">
        <property type="nucleotide sequence ID" value="XM_009164594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A132"/>
    <dbReference type="GeneID" id="20314933"/>
    <dbReference type="KEGG" id="ovi:T265_00745"/>
    <dbReference type="CTD" id="20314933"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13012" checksum="F363434C35D19DAD" modified="2014-10-01" version="1">MSSSVARLLQPNPIHLTRFCSILCTVLLFVKFFDTLVQKLQAITVTSTFSKVLETWLSDSGERMASKPVSRTQIQGKILSPGRNPSGTAMIFFFAHLLCSNTPPNALDSFQLDPSHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A160</accession>
    <name>A0A075A160_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Helicase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164311.1">
        <property type="nucleotide sequence ID" value="XM_009166047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A160"/>
    <dbReference type="STRING" id="6198.A0A075A160"/>
    <dbReference type="GeneID" id="20316109"/>
    <dbReference type="KEGG" id="ovi:T265_01921"/>
    <dbReference type="CTD" id="20316109"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="218"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="485"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123888" checksum="E0F831787BC14871" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Z1</accession>
    <name>A0A075A1Z1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Low-density lipoprotein receptor domain class A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164015.1">
        <property type="nucleotide sequence ID" value="XM_009165751.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A1Z1"/>
    <dbReference type="GeneID" id="20315873"/>
    <dbReference type="KEGG" id="ovi:T265_01685"/>
    <dbReference type="CTD" id="20315873"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1158"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="400"/>
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        </location>
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            <end position="555"/>
        </location>
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        <location>
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            <end position="1195"/>
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        </location>
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            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER32257.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1725" mass="189282" checksum="7E61BB08D00345B4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="GeneID" id="20314947"/>
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    </dbReference>
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            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="202" mass="22933" checksum="C5007F7834A84760" modified="2014-10-01" version="1">MMEGVIIKTVNCNILPVPSCHATRRKHEGWDTARSPRPRQRKTGGRGRVRNTDLSVKHEFTDRNVRGLNMTFASRHPCRGLGNRQYPSPHAAYWWHGTSTPSVKPFSMSAPCSKLVNKPQLLSHWTCLALVCAVYQKQEFKIQTRWLSETAPSLSRDSGYSPLAIQRLLRQDVKGLALPQVTRRRDRCPSGYPLAENSVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Opisthorchis viverrini</name>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="KER21499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12773" checksum="FEB9B7144754017D" modified="2014-10-01" version="1">MSSTRSCVGWNVLRMPNHHLLKRVLFSMPNSRWRKQRGGQPLTYQRSMKEITKRLGAWKAKIRYVLKNNISYKPCAICTLVAAATLSITGKREPGTYNQTLDAKACSVCSEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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    <name>A0A075A2Y9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ESRP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075A2Y9"/>
    <dbReference type="GeneID" id="20314439"/>
    <dbReference type="KEGG" id="ovi:T265_00251"/>
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    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008866"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115593" checksum="7631E6DFFDF03463" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3A0</accession>
    <name>A0A075A3A0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163451.1">
        <property type="nucleotide sequence ID" value="XM_009165187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3A0"/>
    <dbReference type="STRING" id="6198.A0A075A3A0"/>
    <dbReference type="GeneID" id="20315390"/>
    <dbReference type="KEGG" id="ovi:T265_01202"/>
    <dbReference type="CTD" id="20315390"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32145" checksum="1EE44F2A5533A91F" modified="2014-10-01" version="1">MKLERLGAAHSVEEHHKREIQLGFSIGFITVVHGACVNTKEELVAAWGDSLHNSADGRGLRELVTSPLSNRWLVFPERVFPRIFIRGIQLRCNLLRTRVRSARHGHGGQTILCRGNCGQPESLVHILQSCWITHDARCARHNRVARELAKRLRRLGYTVFEELRAPTSTSFIKPDLIAVRDRRATVIDVSIVSDGRGVIVWNEKKQKYDADEYSLAIISALHAIGCDVDFLVHQPMIISYRGICFPQSAKAVIGLGLPKVAVSDLCFLAIVGSLRTYDTFMRGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4P1</accession>
    <name>A0A075A4P1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163078.1">
        <property type="nucleotide sequence ID" value="XM_009164814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4P1"/>
    <dbReference type="GeneID" id="20315107"/>
    <dbReference type="KEGG" id="ovi:T265_00919"/>
    <dbReference type="CTD" id="20315107"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11640" checksum="05AFBC4A79F60ED6" modified="2014-10-01" version="1">MSDVIGVPDSSNDDPHCAHEKLTEEQHNLKEKSNFKTLDAQKHSGGICVPRYLTGNSWLAGQSIVITRTVAGSSFDELGTRITSLNSLACSDVKIQMRRVQRALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4R1</accession>
    <name>A0A075A4R1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596900">
        <property type="protein sequence ID" value="KER22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173850.1">
        <property type="nucleotide sequence ID" value="XM_009175586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4R1"/>
    <dbReference type="STRING" id="6198.A0A075A4R1"/>
    <dbReference type="GeneID" id="20329028"/>
    <dbReference type="KEGG" id="ovi:T265_14862"/>
    <dbReference type="CTD" id="20329028"/>
    <dbReference type="OrthoDB" id="6284542at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="34796" checksum="EF6DB8AA481A6683" modified="2014-10-01" version="1" fragment="single">MLLRPCYIFGSAALFFCKEEWTTSTREVIWIDLLFIAFISTAFYTDVFHLDDLDWPLSRIEEQRRQTDRQNIGIQVGGDDAQWPEDKDAMRENESQMDSNVVDQSDAKEEIERTDDRYSNHSEQIHADDGLINTDSKIDHDNDEKEPLHTDFHGFDETSENGIGQKDENVLTEKSYVNRDVDGSENVKESTGVSDDAIDDCNFEKGEYTAVVTVPDHIPEHGEDDGTEDGDTVINQFTGDDGELQEDEQPNHTHEEQQEKDAHISDGNDIYTDQVDYTKILLSRESSSSDCTMKISMAIYTHVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A555</accession>
    <name>A0A075A555_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162850.1">
        <property type="nucleotide sequence ID" value="XM_009164586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A555"/>
    <dbReference type="GeneID" id="20314925"/>
    <dbReference type="KEGG" id="ovi:T265_00737"/>
    <dbReference type="CTD" id="20314925"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="464" mass="52477" checksum="5814D5FDCEC616D6" modified="2014-10-01" version="1">MPTKTDRIPHGIALLRSFRITRLLRHLTLMKLLLLPSSVVIFVSVGKEYLAVKMLVSLINLTVTWDSPQCLVLTLHPGTRSEGNAEIWIPRALFYTAAAVAADFEAKFACSPYGEGDPSHMPDQNHRNRSSLKCEKPPVGEQIKNKGRVAVYAAYGASCSVKMESLAVIPQRFGPANRLESLLNPSTHNDIFTKYQELVSYLWNIRVLKGYPYIRQPPNKLSVIVKLNFLAIENRIQCPYVTILQTIKRVLFDPSVCLFPFAKHSFTQTSPHRKFERRTNTAAEERVFRNAANNTITFKNRSAMLDGQMFAPFFGAYTVNPWDPLTDNASYDLGMEAQATFGNFLILSTDHPIRLPAHKESSRKQLQDSSLERRVEIPSATSKVTTVKPSNKANDTPTNRLGHLERKDRRNQVTSDRTKKESDDVHVKLEDNSPNRIRSQLQPSYDSKEKGTVPEAKMKPQIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A567</accession>
    <name>A0A075A567_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter, SSS family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_09393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596892">
        <property type="protein sequence ID" value="KER22564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173701.1">
        <property type="nucleotide sequence ID" value="XM_009175437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A567"/>
    <dbReference type="STRING" id="6198.A0A075A567"/>
    <dbReference type="GeneID" id="20323562"/>
    <dbReference type="KEGG" id="ovi:T265_09393"/>
    <dbReference type="CTD" id="20323562"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER22564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="86487" checksum="0EB5304F9562498B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5B5</accession>
    <name>A0A075A5B5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165435.1">
        <property type="nucleotide sequence ID" value="XM_009167171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5B5"/>
    <dbReference type="STRING" id="6198.A0A075A5B5"/>
    <dbReference type="GeneID" id="20317015"/>
    <dbReference type="KEGG" id="ovi:T265_02827"/>
    <dbReference type="CTD" id="20317015"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="62328" checksum="D27A1ED05A218E7B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAT2</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_01196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="12940" checksum="65FCD43CF8DBD624" modified="2014-10-01" version="1">MNKGEMKDKSKKPRILLARLLKTLRQPTTDFALLGAHQPSSIQVASVDSVIYQTSTLNEEHTSSDSWNLHVSFVMHALGTGAGQQQILQVGESADGTDTDQHGAQQRVQGHKQDDFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAV3</accession>
    <name>A0A075AAV3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER24674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171580.1">
        <property type="nucleotide sequence ID" value="XM_009173316.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20321899"/>
    <dbReference type="KEGG" id="ovi:T265_07720"/>
    <dbReference type="CTD" id="20321899"/>
    <dbReference type="OrthoDB" id="6275016at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="482" mass="54169" checksum="C8830B2FB117BACD" modified="2014-10-01" version="1">MSEENLSYYVQHSLPNSTSWSGPIQPTLQKCQTQPELDDPRAYNTRRSWARSKRISLGCLEWRTSNPGPNRSSRSKSGGRRKSVGCETSYLPESEVAQSAGEFTGFQLYRTCRSKASLGADALLRRLRMRSLVKDRRSRSKTGEDLQSACSMQRSCSTPRPCHLSESCEEWQDQNAVFKSRSCGSHLNSTKQSVLSLKSAPEMVSSSTTRDAIVLEPDFFQLPPRDKGLSWRILSDKSFVVRPKYDARHEHTSEYTKRLVVEHGNLSFKGNLIVDVDYNRSNSRDGRRSTRLAELRTRYFIPPTSNHIVNITSQTDPMPTPYGTCPCFTHTDALPGRPRSSCDSQLYRPQSQPSCVCTDPAIHRYPPENRFPTHWSSTLPMSPSYVLNPAHMSIPTSGHVISDYHEPNLLRHCSAVVGARYPHGFVAEHSPHYPHTHHGQSTRHSGVIYAAPNQPVPSYAPNYPPAGCGQHQPGKFFLACFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACM4</accession>
    <name>A0A075ACM4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170733.1">
        <property type="nucleotide sequence ID" value="XM_009172469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACM4"/>
    <dbReference type="STRING" id="6198.A0A075ACM4"/>
    <dbReference type="GeneID" id="20321224"/>
    <dbReference type="KEGG" id="ovi:T265_07045"/>
    <dbReference type="CTD" id="20321224"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="739" mass="84618" checksum="DE83690E01BFB15C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD04</accession>
    <name>A0A075AD04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170506.1">
        <property type="nucleotide sequence ID" value="XM_009172242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD04"/>
    <dbReference type="STRING" id="6198.A0A075AD04"/>
    <dbReference type="GeneID" id="20321039"/>
    <dbReference type="KEGG" id="ovi:T265_06860"/>
    <dbReference type="CTD" id="20321039"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037947">
        <property type="entry name" value="Protein_XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037947-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="283" mass="31240" checksum="F8EA07093222E417" modified="2014-10-01" version="1">MTACQQFRARDCENIIVLLACATEPIIEASSGMKFGPYQCLYEELDAQFKSAGLSIFNCNWSEIYDFTQDTGAESNFELLGPEEADARKYMLTPKEALENESKKNDSQTVSNENTVSLLNRLSSVSVSLNPNDSLVPRTLGSSVQLLIRKESCTTTQLNGSALIAVFDHPSANECAKAIVTLLREYPSCYLIRTRFSRFNEYDMERIFGIRAKSKQAKVGAGGVITLEVAGPALVVGRSCEEVVQKASSLFEPGFVHVTSEPSLASRQIDLLNGLYRMHLDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD20</accession>
    <name>A0A075AD20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170463.1">
        <property type="nucleotide sequence ID" value="XM_009172199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD20"/>
    <dbReference type="STRING" id="6198.A0A075AD20"/>
    <dbReference type="GeneID" id="20321004"/>
    <dbReference type="KEGG" id="ovi:T265_06825"/>
    <dbReference type="CTD" id="20321004"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="208" mass="24048" checksum="30FCB1F8B16FDAF0" modified="2014-10-01" version="1">MYTIIDSLRLSGTVSFTQAGQALSEESTAILEESMWKVVRTNGRTLMRLKAAPHLRSTFFLKAKFLDWKIRNRECDGELEAERKQIDEEQTDMQGDEKEEHFQSQVVPDEDDDEEKEELMNLIYEDAHQLISAIVEKAEQNLATFQRWSLSNLAVPQPSGTLRMAWQLGTEGVLYYYYYIIIIVGCDRAFRRLKSLQFEAPPSQLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADG7</accession>
    <name>A0A075ADG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_12441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162121.1">
        <property type="nucleotide sequence ID" value="XM_009163857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADG7"/>
    <dbReference type="STRING" id="6198.A0A075ADG7"/>
    <dbReference type="GeneID" id="20326609"/>
    <dbReference type="KEGG" id="ovi:T265_12441"/>
    <dbReference type="CTD" id="20326609"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="489" mass="55107" checksum="222625924FF404E3" modified="2014-10-01" version="1" fragment="single">MNPYYPYGEYVSSHLPNRVSPLINEILFPKCVQTAGLVPRFTVEENCSWSDLFNQLSSVHPYLQNSIINHMLTFCTTPHSEVVQKREITSTEYQQRNGPAAHSLPLTHNESPLRSTKEVSTYAVEDKLMLSDEFRHHPVTGSPTSMQGAVGVLSLPYQKDRNLGAEPIKRTTLNNFQKPSIAESSCKRRSADKSCTEDEQADLLKRYRTSYSQQQLRILEQTYQAERYISRPQRSKLAQDLKLPENTIKVWFQNRRMKEKRQSLMLPTLAGLVPESTDEGKTSIAHAPNPGRSPEPNSYFTENKPTNIHTSSDLSNGEIIQQLTSVVGRTKAETEKATANHAAKSSTVVWCKLSEQTSSSSSLTPLRSNQLIRENKSENLEASHDHALQKTEHLLNRFYSLPTPAAKEEAHTTTAPLRSMAKYFCGPRWTDQYSPVHIFSPTNRQSRTDENASHLNSLSTESASDRGVPPLHNSVHSKIMDSAPEDRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE58</accession>
    <name>A0A075AE58_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169740.1">
        <property type="nucleotide sequence ID" value="XM_009171476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE58"/>
    <dbReference type="STRING" id="6198.A0A075AE58"/>
    <dbReference type="GeneID" id="20328144"/>
    <dbReference type="KEGG" id="ovi:T265_13977"/>
    <dbReference type="CTD" id="20328144"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="21023" checksum="AA2CCE2EBEFF957D" modified="2014-10-01" version="1" fragment="single">LLNEAACLGILDKVEQLIQNGASVHHINKVNGMTPLHWSELRGHNDISDYLLVHGADPSKPRLDGKKPSDLRLSVPLSYRPNYLNYTEFTHASRDVCVVNSEQPVSSQKSDLLLLKIRLANSVDPDFYEIDAPVSTCTFDAFRELIATELSVQPSEIKKIRKLPNIILRKESDLRRLMPGAELEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE90</accession>
    <name>A0A075AE90_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169684.1">
        <property type="nucleotide sequence ID" value="XM_009171420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AE90"/>
    <dbReference type="STRING" id="6198.A0A075AE90"/>
    <dbReference type="GeneID" id="20320394"/>
    <dbReference type="KEGG" id="ovi:T265_06212"/>
    <dbReference type="CTD" id="20320394"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER26569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="450" mass="51149" checksum="CF57B6A3BA74B61B" modified="2014-10-01" version="1">MVASFKRAKSAFPVRLLYKHSWVVVRTIDFLDYAIFEHLLYPFMTPAVDGAVADGSRLSNLVVFQPSCFLLVKWQLGTERLLQLNEFYDEIDDSDKLGLWFSVLLLLYSERKRSLFNYNILLMPSCCFARRKHEGWDTATLPKHRQKQSRFLSCVQTTSSLPSTVGKSFSCSTQAAKPHEGGTRAEILSGRPSLDRGSREAEILWAFSIYLESVAIMPQLFMISKTGEAETITSHYLFALGAYRALYLLNWAYRYVVESHLDHIALIAGIVQTLLYCDFFYLYITKGAFDLLLISHQLILWAFSIYLESVAIMPQLFMISKTGEAETITSHYLFALGAYRALYLLNWAYRYVVESHLDHIALIAGIVQTLLYCDFFYLYITKGGLGSGARRPKWLERKFTDSEVRGSNPTSASRLPLSRPGQPGSIPALVQPSGDMTFRHRKGATAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEI2</accession>
    <name>A0A075AEI2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic Fe-S cluster assembly factor NUBP2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169466.1">
        <property type="nucleotide sequence ID" value="XM_009171202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEI2"/>
    <dbReference type="STRING" id="6198.A0A075AEI2"/>
    <dbReference type="GeneID" id="20320214"/>
    <dbReference type="KEGG" id="ovi:T265_06032"/>
    <dbReference type="CTD" id="20320214"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29348" checksum="1DBC3A26BF9EDDE5" modified="2014-10-01" version="1">MQNGTQSVSVVVVVISGKGGVGKSTVASQLALGMWSKGMTVGLLDTDFCGPSIPRILGLEDRKVHACPEGWMPIYADGPMQRLRVMSIGFLVDQPDTAVVWRGPRKSSMIETMLNSVCWGQLDCLVIDTPPGTSDEHLTVLNQIQQLPEDKVAGAVIVSTPQRVSLCDVRREIGFCSKTGLKILGLVENMSGYRCSNCSHCCNLFSSGGAEFLAKEKQLPFLGRLPLDSALTALCDSADRFDLKSHTTEDTMKILQELFRHCPTLASACPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEZ6</accession>
    <name>A0A075AEZ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin motor domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_05691</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169024.1">
        <property type="nucleotide sequence ID" value="XM_009170760.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AEZ6"/>
    <dbReference type="GeneID" id="20319873"/>
    <dbReference type="KEGG" id="ovi:T265_05691"/>
    <dbReference type="CTD" id="20319873"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="3"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="1648"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1560"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="606"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1596"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER27224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1806" mass="203575" checksum="31CB63FECA2002C8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFE4</accession>
    <name>A0A075AFE4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168613.1">
        <property type="nucleotide sequence ID" value="XM_009170349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFE4"/>
    <dbReference type="GeneID" id="20319540"/>
    <dbReference type="KEGG" id="ovi:T265_05358"/>
    <dbReference type="CTD" id="20319540"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="530"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124244" checksum="C429F770B3406514" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFH1</accession>
    <name>A0A075AFH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596716">
        <property type="protein sequence ID" value="KER27729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168539.1">
        <property type="nucleotide sequence ID" value="XM_009170275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFH1"/>
    <dbReference type="STRING" id="6198.A0A075AFH1"/>
    <dbReference type="GeneID" id="20327908"/>
    <dbReference type="KEGG" id="ovi:T265_13741"/>
    <dbReference type="CTD" id="20327908"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15847">
        <property type="entry name" value="SNARE_syntaxin7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27665" checksum="0F42EA667285CFFE" modified="2014-10-01" version="1" fragment="single">QNVHKIGQLGNELETLNQNINVSGNSRIKSELLNRKEKDAIKLIEVTGVKFTELASHPIVEQTTKIHAERLKTDFQRSLQRFQRIQAEIKRRLIIEAQRNEPPVADLLGLEADGVRTNGNEDDSMLFQSGQLQTQVHQGDVTQLGYVLQQEEQMQAIEEDIMNVNIIFEQLSTLVYDQRTAVDTIEDNVESAYVNQVSGTTQLVKAAQSRQRARKRCCICSIVLVIALCITILVLIIIYGPKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFL6</accession>
    <name>A0A075AFL6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168365.1">
        <property type="nucleotide sequence ID" value="XM_009170101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFL6"/>
    <dbReference type="GeneID" id="20319351"/>
    <dbReference type="KEGG" id="ovi:T265_05169"/>
    <dbReference type="CTD" id="20319351"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12620" checksum="B03ECCF9445DE39C" modified="2014-10-01" version="1">MPGTKTERTFLTSIPIQKDHKMPQAQRLATSTPSVFTSNQANARFSQDFQSSQTNSLMDLDGRKQLVEFRSAELPIMKSVFSILNSMQHISVGLLRAQDSEQVDTVFNEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHE1</accession>
    <name>A0A075AHE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166551.1">
        <property type="nucleotide sequence ID" value="XM_009168287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHE1"/>
    <dbReference type="GeneID" id="20317927"/>
    <dbReference type="KEGG" id="ovi:T265_03740"/>
    <dbReference type="CTD" id="20317927"/>
    <dbReference type="OrthoDB" id="413835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24638" checksum="65C1A3F23225BF74" modified="2014-10-01" version="1">MEFRLTDPVHNVCRKPKKGEVVPFPLNFMIDEIMRRTLESLQNPGVHIASEENLADLEYADDIVLMFEEEEKAQGLTVMPPEGNTRADILPGGPSLDMGSRGGRGRVRTTDPPVRRSTGKPPQLEQTSRDLPSSADKWPHWTKPGSPTKQSTAFSGQPGRNDKQQAVAMTLEQQMFRQHESKDPTGEREKVFAAESFSTLSWPVARANRNWAPGAGCTPSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHE9</accession>
    <name>A0A075AHE9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166480.1">
        <property type="nucleotide sequence ID" value="XM_009168216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHE9"/>
    <dbReference type="GeneID" id="20317861"/>
    <dbReference type="KEGG" id="ovi:T265_03674"/>
    <dbReference type="CTD" id="20317861"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="50" mass="5481" checksum="121AF3D72718A121" modified="2014-10-01" version="1">MSENSLHGPSEMIPKSPELARSGIPTARRANHNLFITSEKSSVSILDRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN9</accession>
    <name>A0A075AIN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164287.1">
        <property type="nucleotide sequence ID" value="XM_009166023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN9"/>
    <dbReference type="GeneID" id="20316085"/>
    <dbReference type="KEGG" id="ovi:T265_01897"/>
    <dbReference type="CTD" id="20316085"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21296" checksum="E519989F4116834B" modified="2014-10-01" version="1">MSPRMVTKRLQANCQARRTDQQPPDQQPKNACACSLTTRSVVGIRPLTLDFLYLGLGNLIQPPCFFRGAWQLGTKWGLLALKEPNDHNYPTVVVWGLLALKEPNDHNYPTVVVWVILPASGNIAISRIRSRWTKWLEREFTDKIRGSNPTYATRLPLSRLTQPGSIPALVPPSCGMTAKHRKGATAEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ70</accession>
    <name>A0A075AJ70_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163380.1">
        <property type="nucleotide sequence ID" value="XM_009165116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ70"/>
    <dbReference type="STRING" id="6198.A0A075AJ70"/>
    <dbReference type="GeneID" id="20315343"/>
    <dbReference type="KEGG" id="ovi:T265_01155"/>
    <dbReference type="CTD" id="20315343"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="518" mass="57268" checksum="06F13683246AB119" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJP8</accession>
    <name>A0A075AJP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162526.1">
        <property type="nucleotide sequence ID" value="XM_009164262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJP8"/>
    <dbReference type="STRING" id="6198.A0A075AJP8"/>
    <dbReference type="GeneID" id="20326706"/>
    <dbReference type="KEGG" id="ovi:T265_12538"/>
    <dbReference type="CTD" id="20326706"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="63"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="443" mass="50691" checksum="FECDA0F8A7A5D959" modified="2014-10-01" version="1" fragment="single">QELQIPFYFLLSTLITKHTGLNVDADDYTPSHWLSGDTAPRYRLEPPCPPKHVLLHYSAFRVLWDWTILLLTGYTAVVVPLRLAIIPRPTWGRSPHDYTSAIRTTRLNVPDSLAIADAVIDIIFCLDIVLNFHTSFVGAGGEVVAEPPIIRTNYLSGWFTLDLLSCLPYEVFKYIWPAKNQSIHGLLDGLRIIRLLRIGRAARRIDQYLEYVSTLLLLMILCFFLLAHWFACAWYAVGVLDLENKIQYGWIPRYFNDSLKPQNWDEFINADYFFPNVTFPQDAHPYYQSTETENLKIWWDNYSSENSVLVRGTRVESDEKDGGSKRHAPLQNSVDKWSAYVTALYFSLSLLTTIGFGNVAAFTETEKLLSCVCMLIGALVYATIFGNITTIVQELYATRTRYNEIMKGVKDFLRIHEVPQELGERVIDYITSSWSVNKGIDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJV8</accession>
    <name>A0A075AJV8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162209.1">
        <property type="nucleotide sequence ID" value="XM_009163945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJV8"/>
    <dbReference type="STRING" id="6198.A0A075AJV8"/>
    <dbReference type="GeneID" id="20314425"/>
    <dbReference type="KEGG" id="ovi:T265_00237"/>
    <dbReference type="CTD" id="20314425"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF42">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704661" description="Fibronectin type III-like domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="728"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="823" mass="91538" checksum="2334701538BC174C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTE1</accession>
    <name>A0A074YTE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL613701">
        <property type="protein sequence ID" value="KER18061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178192.1">
        <property type="nucleotide sequence ID" value="XM_009179928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTE1"/>
    <dbReference type="STRING" id="6198.A0A074YTE1"/>
    <dbReference type="GeneID" id="20330487"/>
    <dbReference type="KEGG" id="ovi:T265_16322"/>
    <dbReference type="CTD" id="20330487"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21454">
        <property type="entry name" value="DLC-like_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10601" checksum="B0B1D903D0F1CD75" modified="2014-10-01" version="1" fragment="single">MSLDKQVDITNKFVELLKETSGRPEDLNEVAKNLKDYLDKQYGRVWQTVLVAGSYWMKFSHEPFMSLQFKCGPHICLVWRTPCIERDSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU69</accession>
    <name>A0A074YU69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605004">
        <property type="protein sequence ID" value="KER18258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177995.1">
        <property type="nucleotide sequence ID" value="XM_009179731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU69"/>
    <dbReference type="GeneID" id="20330347"/>
    <dbReference type="KEGG" id="ovi:T265_16182"/>
    <dbReference type="CTD" id="20330347"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9646" checksum="C3395FE12E4B08A6" modified="2014-10-01" version="1" fragment="single">MIEGVCPMGAARSKPLIPRSSRMMALRKFKNFGRDLTDTRPNTNSAQPAKTSKGTAPILRLPNDTENTVRKVGEAYLASGDTDQLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV71</accession>
    <name>A0A074YV71_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599523">
        <property type="protein sequence ID" value="KER18583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177670.1">
        <property type="nucleotide sequence ID" value="XM_009179406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV71"/>
    <dbReference type="STRING" id="6198.A0A074YV71"/>
    <dbReference type="GeneID" id="20330126"/>
    <dbReference type="KEGG" id="ovi:T265_15961"/>
    <dbReference type="CTD" id="20330126"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13665" checksum="D2ECE88CBC702833" modified="2014-10-01" version="1" fragment="single">PRDSDALVTIEQSAAPGSAVIISACRFCLRDPEGDEKLVRGTCLECRTLIRSFVQRSTRLDDLACLRDASCHLERPVSWVPTKDLLSKVRARRLQQEYGPPSEDWCDSCKVHHCLKLGARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWH5</accession>
    <name>A0A074YWH5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597325">
        <property type="protein sequence ID" value="KER19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177134.1">
        <property type="nucleotide sequence ID" value="XM_009178870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWH5"/>
    <dbReference type="GeneID" id="20326164"/>
    <dbReference type="KEGG" id="ovi:T265_11996"/>
    <dbReference type="CTD" id="20326164"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6895" checksum="5FE76EFEAE6DF6EE" modified="2014-10-01" version="1">MISCEAECTNLDGAGEYEETCDIESVHTLDRVHPQGFTHKHTHVLPNPNDERIGNYLDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXV5</accession>
    <name>A0A074YXV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597166">
        <property type="protein sequence ID" value="KER19621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176633.1">
        <property type="nucleotide sequence ID" value="XM_009178369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXV5"/>
    <dbReference type="GeneID" id="20325826"/>
    <dbReference type="KEGG" id="ovi:T265_11658"/>
    <dbReference type="CTD" id="20325826"/>
    <dbReference type="OrthoDB" id="9971251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF28">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="94"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1147"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1227" mass="137665" checksum="DEDAE778CCCF3A2A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXY3</accession>
    <name>A0A074YXY3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597185">
        <property type="protein sequence ID" value="KER19528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176725.1">
        <property type="nucleotide sequence ID" value="XM_009178461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXY3"/>
    <dbReference type="STRING" id="6198.A0A074YXY3"/>
    <dbReference type="GeneID" id="20325894"/>
    <dbReference type="KEGG" id="ovi:T265_11726"/>
    <dbReference type="CTD" id="20325894"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="24028" checksum="59806F6F931F8A99" modified="2014-10-01" version="1">MLTFVLFEQCLTDSFSTGSTSVSNQLVPALAILLTLSEKKKGNAVAFFACVAQVNGNRWLTRKNAPRSLDPVYQSVNPCIGTRQKTKIRASKLRGVPESDLQKQLGDLKTELSSLRLYRVTRGTSYHGKLKKIRVLRKSIARVYTVMHQAQKERQREAYRSKRYVPKDLRPKKTRAIRRRLSRKERSIHSAKSMHKARAYPPRIYAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0V5</accession>
    <name>A0A074Z0V5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597040">
        <property type="protein sequence ID" value="KER20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175664.1">
        <property type="nucleotide sequence ID" value="XM_009177400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0V5"/>
    <dbReference type="GeneID" id="20329452"/>
    <dbReference type="KEGG" id="ovi:T265_15287"/>
    <dbReference type="CTD" id="20329452"/>
    <dbReference type="OrthoDB" id="6230768at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="24252" checksum="D95526508EC3E119" modified="2014-10-01" version="1" fragment="single">MPSVAQLGYPFNLTCVVHLRKTNAVFVAIDWFRPEHSYDNLIQSHTHGLPGLSGLHESTMSLDTMSNNQTAFMIHWFAQTFVQLTNRPSLGIRVYKQLLADPLKSYKSEVVFESATVSSLDAGFYECRAYEPVNRGDVRILDRAIVYVDVHRPFPYKQRDTGDWPERVGRLLALHWKILFDDSDRRVHDQYTQNDVATKNKDGYLPLGSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1T6</accession>
    <name>A0A074Z1T6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597203">
        <property type="protein sequence ID" value="KER19457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176793.1">
        <property type="nucleotide sequence ID" value="XM_009178529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1T6"/>
    <dbReference type="GeneID" id="20325942"/>
    <dbReference type="KEGG" id="ovi:T265_11774"/>
    <dbReference type="CTD" id="20325942"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12695" checksum="459603AF84EC428C" modified="2014-10-01" version="1">MQKLSPQNMRRSKDTNPQDSSNKVYFATHLDRTMKGQLGRYSFGIKHVEAANIPTFSLARKASQVTSSLSSGRDGNQLQMLCSLCCCSLSPPGTIVQRFKHLGWDPSLSFKQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1X8</accession>
    <name>A0A074Z1X8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PBZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_15195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597004">
        <property type="protein sequence ID" value="KER20988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175262.1">
        <property type="nucleotide sequence ID" value="XM_009176998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1X8"/>
    <dbReference type="STRING" id="6198.A0A074Z1X8"/>
    <dbReference type="GeneID" id="20329360"/>
    <dbReference type="KEGG" id="ovi:T265_15195"/>
    <dbReference type="CTD" id="20329360"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="13">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER20988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="563" mass="63963" checksum="5D85BED1BD91C4FA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2C6</accession>
    <name>A0A074Z2C6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_15151</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175070.1">
        <property type="nucleotide sequence ID" value="XM_009176806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2C6"/>
    <dbReference type="STRING" id="6198.A0A074Z2C6"/>
    <dbReference type="GeneID" id="20329316"/>
    <dbReference type="KEGG" id="ovi:T265_15151"/>
    <dbReference type="CTD" id="20329316"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="27347" checksum="79424E438DB117D0" modified="2014-10-01" version="1" fragment="single">GGLHYLSEESPDFLSIQETKCASDKIPSEAHIEGYELHWSSAEKNGYAGTALYSKTKPLKITRGLGKTTQNSEGRVITAEFPDFYLVSVYVPNSGQGLVRLPYRQHQWDPEFRQHLKELDKVKPIIVTGDLNVAHEEIDLANPSTNHRSAGFTDEERENFTKLLKEVDLVDTYRALYPDREKAYTFWSYRKMARPSNTGWRLDYFLVSRRIMPNVCDHEIRCGVQGSDHCPIVLYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z309</accession>
    <name>A0A074Z309_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597119">
        <property type="protein sequence ID" value="KER19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176341.1">
        <property type="nucleotide sequence ID" value="XM_009178077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z309"/>
    <dbReference type="GeneID" id="20329597"/>
    <dbReference type="KEGG" id="ovi:T265_15432"/>
    <dbReference type="CTD" id="20329597"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="404" mass="45151" checksum="A3EE2DE391C902CB" modified="2014-10-01" version="1" fragment="single">NHGPYDKELLRGRDGSSGESANLLTGRSVVRTRPLPLDFPCLGLGNRAVSQSSCFSRVAWQLGTRRVLQLNDLLFIYFAHCNPPIVELTFSLLTYIYTYNIPFSCSTLSVPYCHATRRLHEGWDTVRLPKPRQGKSRGRGPVRTTDLPVINSTRDITKLSERSFVTPFRCIAAMPPGGCTRAELLPGCPSLEGSGEMLRMEREFTERKFRSSNPTSASRLLPYRLGQPDSIPALVQPSGGMAVRHRKGATAGRANAVNTTEDWTFVIKLLYLESKPIAVSIFQRNQQRLPWDLPQRRPWKKLSITLDQSQLTRVRAGTLSTFSCSTLSPPNCHATRRRHEGWDTARLSKPRQGKSRVEVGFESQTFRSVNSRSNHSVHLAPSTMYQLGLAPILRNQGIVPVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3J9</accession>
    <name>A0A074Z3J9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596953">
        <property type="protein sequence ID" value="KER21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174629.1">
        <property type="nucleotide sequence ID" value="XM_009176365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3J9"/>
    <dbReference type="GeneID" id="20329215"/>
    <dbReference type="KEGG" id="ovi:T265_15049"/>
    <dbReference type="CTD" id="20329215"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="27612" checksum="61EFC86C620B5D64" modified="2014-10-01" version="1" fragment="single">MKTERFTRVPEREFTERKVRGFNPTSASRLPLSKLGHGVSPTSCFLQVARQLGTKGSLQLNDHYYHYWSTTLSNMPHLQVSKTCKPITENRLLKTLRQTTTGFALPLRAHQVGAVSVNLMIYLSPNWTVFEKFTHLQINLVFKRDSIKSLIHDIPQLNVLHAGCLTIQLARYSRYRKLTCYKSRRNLQIDLVFMRNSTESLVYDILQLNVLNTGRPMIQLARYSRYRSIYLHRKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z495</accession>
    <name>A0A074Z495_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174338.1">
        <property type="nucleotide sequence ID" value="XM_009176074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z495"/>
    <dbReference type="GeneID" id="20324037"/>
    <dbReference type="KEGG" id="ovi:T265_09869"/>
    <dbReference type="CTD" id="20324037"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9072" checksum="0142039CB1A5B19F" modified="2014-10-01" version="1">MKGVVYQLRATAPNEFFEQPSCSFGDGNYFAVDEAGSFVKSAHEQDQLIGSVSQLEQLQLTGVISQHVQRGNTPVIDLNLISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4D6</accession>
    <name>A0A074Z4D6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174345.1">
        <property type="nucleotide sequence ID" value="XM_009176081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4D6"/>
    <dbReference type="GeneID" id="20329151"/>
    <dbReference type="KEGG" id="ovi:T265_14985"/>
    <dbReference type="CTD" id="20329151"/>
    <dbReference type="OrthoDB" id="6225916at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="13226" checksum="7B30217AB7FD8753" modified="2014-10-01" version="1" fragment="single">YRCWSISLEICRVPAHLITHSHSGFFSGQLLVCVMAMFFRGESFREFFVRVLNRAPHVVYIVPLAVVCCGAAIKRHYDHRVAGVERVFKYKKLYSIKRQEDVELTSENRDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4M9</accession>
    <name>A0A074Z4M9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605219">
        <property type="protein sequence ID" value="KER18250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178003.1">
        <property type="nucleotide sequence ID" value="XM_009179739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4M9"/>
    <dbReference type="GeneID" id="20330354"/>
    <dbReference type="KEGG" id="ovi:T265_16189"/>
    <dbReference type="CTD" id="20330354"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12837" checksum="81D35432D43D53B3" modified="2014-10-01" version="1" fragment="single">MTHVRCSCRPELIKPSLPTITYWEWLQKEFYRTHAPDMVRNSDAIRLCMKPAPVGIQVRPNPKSVSSDGDPMQLDLPPGAYIECVLHGKNGTTPDMHVYTPDRFNRSRYGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z583</accession>
    <name>A0A074Z583_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase, short chain dehydrogenase/reductase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL600798">
        <property type="protein sequence ID" value="KER18480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177773.1">
        <property type="nucleotide sequence ID" value="XM_009179509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z583"/>
    <dbReference type="STRING" id="6198.A0A074Z583"/>
    <dbReference type="GeneID" id="20330193"/>
    <dbReference type="KEGG" id="ovi:T265_16028"/>
    <dbReference type="CTD" id="20330193"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11018" checksum="B840884A2D4EAA8F" modified="2014-10-01" version="1" fragment="single">MINQHWEEFGLEPTLTTAKIQRMITCNSISTACMTRVLLPRMLSQTTGSAIINISSASSQLPLPYHVLYASTKAFVTQFSDCLEAELERSSVIVQCYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6U4</accession>
    <name>A0A074Z6U4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173452.1">
        <property type="nucleotide sequence ID" value="XM_009175188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6U4"/>
    <dbReference type="GeneID" id="20323356"/>
    <dbReference type="KEGG" id="ovi:T265_09177"/>
    <dbReference type="CTD" id="20323356"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12088" checksum="DE14F690662B710D" modified="2014-10-01" version="1">MDKRNSEPPQTTKTVIKIRSFSVSIHQLFSLLSEFTHNTEKTEPLPKQIIGLRADETIQKLPSKFQASLKLPDRKVLTGGSVDHHNQNSYRAIFRWVGHTNHIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z810</accession>
    <name>A0A074Z810_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KL596948">
        <property type="protein sequence ID" value="KER21677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174565.1">
        <property type="nucleotide sequence ID" value="XM_009176301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z810"/>
    <dbReference type="STRING" id="6198.A0A074Z810"/>
    <dbReference type="GeneID" id="20324215"/>
    <dbReference type="KEGG" id="ovi:T265_10047"/>
    <dbReference type="CTD" id="20324215"/>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000048">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="281" mass="32505" checksum="AC2479B88C5E2C18" modified="2014-10-01" version="1">MKKDLYEAHPKIFQKPEIHGLLEFDWTTYLFVKKRELGGRYWKYTSPVLVILNNEVLGSDEDFRKWAEENHSCYDYRPVALYTMLGNEAYVNALYERNRIFVSMLITIGGERCGPLLLELYSDILPKTCENFRALCTGEKGHVPKNEVESYKMHYKGTSFFRLVKNGWIQGGDVLHSRGNDGCSIYGRTFEDENFAIKHDRRGILSMANAGRHTNDSQFFITLTPTPWMDNLYVAFGRVIEGSLTLDLMEEVPTQNERPTKDICISEIRIMDPKDLSTKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z892</accession>
    <name>A0A074Z892_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596854">
        <property type="protein sequence ID" value="KER23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172929.1">
        <property type="nucleotide sequence ID" value="XM_009174665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z892"/>
    <dbReference type="GeneID" id="20322952"/>
    <dbReference type="KEGG" id="ovi:T265_08773"/>
    <dbReference type="CTD" id="20322952"/>
    <dbReference type="OrthoDB" id="6238993at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="38331" checksum="71458B8453198963" modified="2014-10-01" version="1">MPEPRIKSKRSSSLYNGSSLEHTVYYECTARLVAQKKLKADESFSQDGVEQFIKKSGKSTMANYALCFLRDRIVFKSNKVGVKSASHEPVLYTQIKGGFSVSNFPNMLILGIDYPAQSKRRYESFVFPTVSSANVVKEILLDVRKQPDGILHRSSVSQNTASISGRSLPRLSMPEYVFQASTPLEVAPTVYTSEEVASEEKKPSKSEETIPQNVRVSHALNSPIKSTCTENEPNFDYPRCVENPVTRSDRKISDSYRYKAYRSHPELAQVTQARFSDYRFYSRNRCEVNPRTSVLLDAIRQENREDVLFLNSNECTGTQIADDGPIYMICKREPSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8L0</accession>
    <name>A0A074Z8L0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597177">
        <property type="protein sequence ID" value="KER19565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176685.1">
        <property type="nucleotide sequence ID" value="XM_009178421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8L0"/>
    <dbReference type="GeneID" id="20325867"/>
    <dbReference type="KEGG" id="ovi:T265_11699"/>
    <dbReference type="CTD" id="20325867"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11120" checksum="453917B34EC0601A" modified="2014-10-01" version="1">MLAGGTNVQVERLSPEDPQLGGRFGNGEWYTDNGQCLGVQDKPEFFASTAQKGHILKRKPAFSNDLGEESKTKQNKYAIVCVLSVEKQCPGGVTSSGDETAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8R3</accession>
    <name>A0A074Z8R3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597169">
        <property type="protein sequence ID" value="KER19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176645.1">
        <property type="nucleotide sequence ID" value="XM_009178381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8R3"/>
    <dbReference type="GeneID" id="20325835"/>
    <dbReference type="KEGG" id="ovi:T265_11667"/>
    <dbReference type="CTD" id="20325835"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11103" checksum="E90ED89C7DB8CA38" modified="2014-10-01" version="1">MSTRRARLYWYRQDTSWVNLDLVLGFVQLNYAVKPSALQTANDCCYQYEGPLGLIDRRKPCRAVPTKSSPSSITPTDSCGRARVYNQSLELQWSPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z982</accession>
    <name>A0A074Z982_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_11515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597138">
        <property type="protein sequence ID" value="KER19795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176455.1">
        <property type="nucleotide sequence ID" value="XM_009178191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z982"/>
    <dbReference type="STRING" id="6198.A0A074Z982"/>
    <dbReference type="GeneID" id="20325683"/>
    <dbReference type="KEGG" id="ovi:T265_11515"/>
    <dbReference type="CTD" id="20325683"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20761" checksum="9B54E7D84B9FD812" modified="2014-10-01" version="1">MLLQSFDSPVFKCKEKPSQSTGQAVPITAQQKSLVEDYENLFAKKNLLEKEQEDPVKNSIQAEMRELFEKLDSLSHLHFVPYKHSPEATVLQSKQAMVMEEAGPAATSTADLLAPEEVFAPRGEVLKGATELTSTDRRRHRKKLMRIRSTRRKLKTADPTKNKEAALQKIIRLAHKPGSNIKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9U0</accession>
    <name>A0A074Z9U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597105">
        <property type="protein sequence ID" value="KER20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176241.1">
        <property type="nucleotide sequence ID" value="XM_009177977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9U0"/>
    <dbReference type="STRING" id="6198.A0A074Z9U0"/>
    <dbReference type="GeneID" id="20325514"/>
    <dbReference type="KEGG" id="ovi:T265_11346"/>
    <dbReference type="CTD" id="20325514"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28486" checksum="2BD31890303CB8E8" modified="2014-10-01" version="1">MPRIQYIGRPSLHHYGKLLSEIVRNLKTRGVGRIVVKETEASRYPEPCFYVLERTIPLLSDSSNVRCRAWGRRIFRGHDFGVVLMTNTYEPDWRLVPTCEATALLDRAADPKNAAPKLTSKCVAPMPPLLTLHLRRHSRFPDNIIRAVSESVDPTLPQATREASGFLLLTKLPDEPTSLEIPTEPTVQEQRRIYPPYQVASEGGLIRKRELDRPFYYIRRADTPGLLWKVVTNKDSDDPKSKNEQSNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAF9</accession>
    <name>A0A074ZAF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter, SSS family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596892">
        <property type="protein sequence ID" value="KER22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173705.1">
        <property type="nucleotide sequence ID" value="XM_009175441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAF9"/>
    <dbReference type="STRING" id="6198.A0A074ZAF9"/>
    <dbReference type="GeneID" id="20328990"/>
    <dbReference type="KEGG" id="ovi:T265_14824"/>
    <dbReference type="CTD" id="20328990"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF2">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73363" checksum="6C9D10611906823D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAL3</accession>
    <name>A0A074ZAL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PH domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_11143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175988.1">
        <property type="nucleotide sequence ID" value="XM_009177724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20325311"/>
    <dbReference type="KEGG" id="ovi:T265_11143"/>
    <dbReference type="CTD" id="20325311"/>
    <dbReference type="OrthoDB" id="10063282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990504">
        <property type="term" value="P:dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="297"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="921"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="14">
        <location>
            <begin position="1414"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER20260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1933" mass="218057" checksum="73AA9D5E422B8C87" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBT2</accession>
    <name>A0A074ZBT2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596866">
        <property type="protein sequence ID" value="KER23062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173191.1">
        <property type="nucleotide sequence ID" value="XM_009174927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBT2"/>
    <dbReference type="GeneID" id="20328881"/>
    <dbReference type="KEGG" id="ovi:T265_14715"/>
    <dbReference type="CTD" id="20328881"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="22410" checksum="54B63C940BD8EC32" modified="2014-10-01" version="1" fragment="single">MHVSDRAYVTLVITSDRSDLNSPDALTVIILLYHTPWLTQFHIYEVFLWLLKLPSAHRSNPPLVLRVIYIPLLNVCLNADHTYHQVFQYGNLTAVSKLFQGVLQAISIPRNANCEEFVYAVLKRKQQIRKNEEFRIVHRLNNSQKVVHPVGKCVEDRGPTTAGFYDGLKDVYPLNFSELDYPNVLANEEWVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCB6</accession>
    <name>A0A074ZCB6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173016.1">
        <property type="nucleotide sequence ID" value="XM_009174752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCB6"/>
    <dbReference type="GeneID" id="20323019"/>
    <dbReference type="KEGG" id="ovi:T265_08840"/>
    <dbReference type="CTD" id="20323019"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="217" mass="24597" checksum="977178D8A2AF839E" modified="2014-10-01" version="1">MMQHTQLPGNIPNERFSWVPGESLVKPSLFANEPISLIYTCKMMRDLALLVVIFRKSLKTLIEKSEGLLISIYYQPNHRLLKIHRQPTTGFAFLGAHQVGSRQMNVLHQNAPCFSRYEIRDIAIHAAENSSTAHDRFRPSWGVEREIQLGSSPMCPARYQPDSSKTGILCCLLLASAKVRTIASGGYTKQLHTLHSHSCMNWAHRQTHNGLRTHLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCH4</accession>
    <name>A0A074ZCH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172950.1">
        <property type="nucleotide sequence ID" value="XM_009174686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCH4"/>
    <dbReference type="GeneID" id="20322965"/>
    <dbReference type="KEGG" id="ovi:T265_08786"/>
    <dbReference type="CTD" id="20322965"/>
    <dbReference type="OrthoDB" id="10467270at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="15878" checksum="94284EF2A43EA1C4" modified="2014-10-01" version="1">MSPRLMMKRLQSNCQARRTDQQLNFQYSNRFSFSRNYISNHSPEQFSIPNLWRFVGAGRNKETETARNIIRHQLVVDQVAVDLFAELGNWLANVSSPYEVTSSVRSLVGTSSWPACVYVAFKGYLLSSDVIGAVTYLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCV2</accession>
    <name>A0A074ZCV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171253.1">
        <property type="nucleotide sequence ID" value="XM_009172989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCV2"/>
    <dbReference type="GeneID" id="20321639"/>
    <dbReference type="KEGG" id="ovi:T265_07460"/>
    <dbReference type="CTD" id="20321639"/>
    <dbReference type="OrthoDB" id="10388079at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19339" checksum="B7527F7EA74D4294" modified="2014-10-01" version="1">MQQLECVRTTELTDWRPTNIQGAYSSKTSPIWMQLTNGSNSHRFIIIIIIIDSMTSVFNTDASLPYNHDLFESLIFICVCAIHGCTWAGILPGRPYLDRRTIKVLNQSLWLKSLTARQRCLAGNANALPFLRNKSPHVPTPNLEGHETVFVRPLTIDQPGVRDSVSVAGHSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFL5</accession>
    <name>A0A074ZFL5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium channel voltage dependent KCNQ C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596810">
        <property type="protein sequence ID" value="KER24432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171829.1">
        <property type="nucleotide sequence ID" value="XM_009173565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFL5"/>
    <dbReference type="STRING" id="6198.A0A074ZFL5"/>
    <dbReference type="GeneID" id="20328593"/>
    <dbReference type="KEGG" id="ovi:T265_14427"/>
    <dbReference type="CTD" id="20328593"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="266" mass="29782" checksum="7ED7C9A81C05DAA2" modified="2014-10-01" version="1">MLTNTEKNVVRSIRKIKFFVARRKFKEALRPYDVKDVIEQYSAGHLDMLGRIKILQSRLDRILGRSSAKEDLSPESQVTLSSRIIKIEQKVSNIEAKLNALLNCYLERQPTVYPHNGSRPDCLTAGIRPRQSDCLDVGPTFSCVNPQHRVSDHRPVEPKQQIVSDGKQPPENVEDSTNDGSVEGGNVIRRCMIKSPTEHNLRESSEDATVLRMSASSSCHPKSAAHTNTLPIRRSMKADPIAGRNTRVHFSISNSDQQPTTSVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFN3</accession>
    <name>A0A074ZFN3_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Melanoma inhibitory activity protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175932.1"/>
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    <dbReference type="GeneID" id="20323929"/>
    <dbReference type="KEGG" id="ovi:T265_09761"/>
    <dbReference type="CTD" id="20323929"/>
    <dbReference type="OrthoDB" id="6022771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035459">
        <property type="term" value="P:vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051500">
        <property type="entry name" value="cTAGE_MIA/OTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158:SF33">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705175" description="Melanoma inhibitory activity protein 3" evidence="5">
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            <begin position="19"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="127"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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            <begin position="1125"/>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1503"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1518" mass="166646" checksum="666A950F3E984A4A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFQ5</accession>
    <name>A0A074ZFQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20320770"/>
    <dbReference type="KEGG" id="ovi:T265_06591"/>
    <dbReference type="CTD" id="20320770"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER26111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGL7</accession>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_06398"/>
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    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGT3</accession>
    <name>A0A074ZGT3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173803.1">
        <property type="nucleotide sequence ID" value="XM_009175539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGT3"/>
    <dbReference type="GeneID" id="20323633"/>
    <dbReference type="KEGG" id="ovi:T265_09464"/>
    <dbReference type="CTD" id="20323633"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8279" checksum="B71F7D77ED81E4EB" modified="2014-10-01" version="1">MQTIRDGQSTKVAAQKLPSVFEKYTHLQINLVFKRDSTGSLVYDILQLKVPHTRRLMIPLARYSIYRSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH28</accession>
    <name>A0A074ZH28_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169708.1">
        <property type="nucleotide sequence ID" value="XM_009171444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH28"/>
    <dbReference type="GeneID" id="20320416"/>
    <dbReference type="KEGG" id="ovi:T265_06234"/>
    <dbReference type="CTD" id="20320416"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="17379" checksum="33CB61DCCDCCD59B" modified="2014-10-01" version="1">MSATDCAIGPFPPMSLTTGHTLSTSRSFCEADGLLICGVHVPTNATCEAPDQRCGDTDGQTLTSFHKPNHAGELVRLFKIVCIWEGSEPVERIVLSFTTGRGELRRELLVHSYAPTGVRIQHIVSSCYSFEHRKTGKCNIQPSLGGKAMFSLFGSRVATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI13</accession>
    <name>A0A074ZI13_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170816.1">
        <property type="nucleotide sequence ID" value="XM_009172552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI13"/>
    <dbReference type="STRING" id="6198.A0A074ZI13"/>
    <dbReference type="GeneID" id="20321288"/>
    <dbReference type="KEGG" id="ovi:T265_07109"/>
    <dbReference type="CTD" id="20321288"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047513">
        <property type="entry name" value="FOXJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46805:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="373"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="834" mass="92765" checksum="9AFDABA9218A2EBC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI72</accession>
    <name>A0A074ZI72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_13963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169628.1">
        <property type="nucleotide sequence ID" value="XM_009171364.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZI72"/>
    <dbReference type="GeneID" id="20328130"/>
    <dbReference type="KEGG" id="ovi:T265_13963"/>
    <dbReference type="CTD" id="20328130"/>
    <dbReference type="OrthoDB" id="10250638at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000009">
        <property type="entry name" value="WD repeat-containing protein 19 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="11">
        <location>
            <begin position="183"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="14">
        <location>
            <begin position="619"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="14">
        <location>
            <begin position="828"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER26661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="153994" checksum="E811B8CC57F79F85" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIT4</accession>
    <name>A0A074ZIT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169030.1">
        <property type="nucleotide sequence ID" value="XM_009170766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIT4"/>
    <dbReference type="STRING" id="6198.A0A074ZIT4"/>
    <dbReference type="GeneID" id="20319879"/>
    <dbReference type="KEGG" id="ovi:T265_05697"/>
    <dbReference type="CTD" id="20319879"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27316" checksum="A851B5DAFAD6395C" modified="2014-10-01" version="1">MKVDTTGATHPMEPIPVSEIGELWSVDVTMRHQHQEELGRDNGQYRQLDRSQATVDDPPRKWAGIRSQQITVRPRIQVLCGIAVDPNPKSKLNHYSRVSIVKRGKRVSCRGSNRTSRPQYYDNSRDERERTHPETPVIAWFIIPIAEMRDKCIVVADCHGFIDSAFEAFELQSHEFLVITGFESEVYKAYAKKLGLKSPVFINSEIGQNSFTATFLRGRLGLSSMDRSRSISKQAILAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ30</accession>
    <name>A0A074ZJ30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170476.1">
        <property type="nucleotide sequence ID" value="XM_009172212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ30"/>
    <dbReference type="STRING" id="6198.A0A074ZJ30"/>
    <dbReference type="GeneID" id="20328309"/>
    <dbReference type="KEGG" id="ovi:T265_14143"/>
    <dbReference type="CTD" id="20328309"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="9">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="8">
        <location>
            <begin position="246"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER25772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="440" mass="47787" checksum="64287D2AC4F13E7B" modified="2014-10-01" version="1" fragment="single">MSQSAALFGRPQQPQTKHLLQFKAGKMTINNENWVHADPRKGWVYVYQSGDGKLHFCWIDRKTCLVEDNFIINAQQAEFKRVPQCTTGRVYLLKVKNAKPFFVWMQEPNGKNDSSICSRINDFIASPPTQFTPPASDWLSNFGGFNQFSQNDLLALLTMGVGLGSGLSSESDVSSAQATAVTIGRHLNTGHLDSQTKPTTTLGSAITTPQVTGPGSVPGAIPGKKGEGGKIQLQDLRNILSSISGPSKTSEPPIDLNDAVNMDSLRSLLEKAEVQARLLPHLPNRDPEAKPVSDLGNLTENIRSSQFKSTLKSFSAAFQTGELAPVLSQFKLGSKADEAARRGGETLFLSFGGVARIRIKIPWPQPFEDGDVRTFLEDFEEVAEAAGLETDRSKLAALKTLLRGRVKAALDAARRGPQKVEWAAAKKVLAAEFDTPPVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKE4</accession>
    <name>A0A074ZKE4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168750.1">
        <property type="nucleotide sequence ID" value="XM_009170486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKE4"/>
    <dbReference type="GeneID" id="20319657"/>
    <dbReference type="KEGG" id="ovi:T265_05475"/>
    <dbReference type="CTD" id="20319657"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16779" checksum="1CB087666385DB31" modified="2014-10-01" version="1">MCASSTVIRSKVSQSCIPWFSAPCKGHQLRRTVQSSLPQQCPTESRFLLLWKARKILSAFAIAAHVLRNYTILGAPEKLCATSCDRSLNPGEHTEVHFIWARWPMWLEREFTDRKVLRTNPTPASRLPLSRLGQPGSIPALVLPSGDMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI9</accession>
    <name>A0A074ZKI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168714.1">
        <property type="nucleotide sequence ID" value="XM_009170450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI9"/>
    <dbReference type="GeneID" id="20319625"/>
    <dbReference type="KEGG" id="ovi:T265_05443"/>
    <dbReference type="CTD" id="20319625"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23142" checksum="C91901C976E291AA" modified="2014-10-01" version="1">MMQTFALMKQISSGLLGTKQRWLSETGSCLIASIWKYSTLVPARKAEPSPPVEQEDKGLCGVLDRDSRHPTYDLLSHTFHTEVNRKGGVHLSSVNTSLCPHNAQSRVTTFVVESASPPMASAKSESDTTQQSATRRILKIRSTDLRSHPHSTRSSTNYETNKTGFSLIDESRPPSDSGDSKCCMIRASQTNPEDIMQQNNQQDKPDGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL11</accession>
    <name>A0A074ZL11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169749.1">
        <property type="nucleotide sequence ID" value="XM_009171485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL11"/>
    <dbReference type="STRING" id="6198.A0A074ZL11"/>
    <dbReference type="GeneID" id="20320447"/>
    <dbReference type="KEGG" id="ovi:T265_06265"/>
    <dbReference type="CTD" id="20320447"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="162"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="556" mass="62553" checksum="FFCBC68B7FB2D44C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLA8</accession>
    <name>A0A074ZLA8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169687.1">
        <property type="nucleotide sequence ID" value="XM_009171423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLA8"/>
    <dbReference type="STRING" id="6198.A0A074ZLA8"/>
    <dbReference type="GeneID" id="20320397"/>
    <dbReference type="KEGG" id="ovi:T265_06215"/>
    <dbReference type="CTD" id="20320397"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="22813" checksum="FC6FAE7DAA457B96" modified="2014-10-01" version="1">MDSPVASNGYRTHDSPRGRRCSRSPSRSRSRSRSRRYRSRSGSRDYSRRSPGYGYRSSNRRRFLGPRENAKPSRCLGVFGLSLHTQERDLYDIFSRYGPIDDVQLVYDNYTGRSRGFGFVYFNHLSDAKVAKSEAHGMEVDGRPIRCDFSVTDRPHSPTPGIYMGRPTRRGGPRRRSISPRGRYSRSRSRSRSYDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLT2</accession>
    <name>A0A074ZLT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169516.1">
        <property type="nucleotide sequence ID" value="XM_009171252.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLT2"/>
    <dbReference type="GeneID" id="20320256"/>
    <dbReference type="KEGG" id="ovi:T265_06074"/>
    <dbReference type="CTD" id="20320256"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="4"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1175"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="608"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1378" mass="154851" checksum="E608BDF0E3087F5C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM90</accession>
    <name>A0A074ZM90_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171760.1">
        <property type="nucleotide sequence ID" value="XM_009173496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM90"/>
    <dbReference type="STRING" id="6198.A0A074ZM90"/>
    <dbReference type="GeneID" id="20322035"/>
    <dbReference type="KEGG" id="ovi:T265_07856"/>
    <dbReference type="CTD" id="20322035"/>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="346" mass="38856" checksum="110AC1B8A27B94DF" modified="2014-10-01" version="1">MSYRTQALPNSSDEGSDGGEEDIFWKRKPPHAQKRAATNSDVTMVQATSKRPRNHVWLNVLNECALDEALSGANFHEKRDTSRGVESYLVQSDTDEVDNNIEREFRLSCDKPANRFSGRLPPRRWDPSISRKHVSVNFDSPSDAVKAALVELLNEPNDVLIGQIVDVLGVQRSLEFYFLTEDVEEAGGIYYADGSQRRSRGGVFLNLIKRSDEVTEDEKKAMFALSRRIKDRIKRKRKQLKQAKEKQLIASSVTLSDVSVEISEIEDVEATTRVPANFEDEGSPQAMDFKAGHNSEAPNHGLVNEENPTGYSTSFSVKMHPVDPRMDECEEGELTSTESEDESTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMI1</accession>
    <name>A0A074ZMI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169273.1">
        <property type="nucleotide sequence ID" value="XM_009171009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMI1"/>
    <dbReference type="STRING" id="6198.A0A074ZMI1"/>
    <dbReference type="GeneID" id="20320062"/>
    <dbReference type="KEGG" id="ovi:T265_05880"/>
    <dbReference type="CTD" id="20320062"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="668" mass="74925" checksum="86C8F72C05CA18FE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN57</accession>
    <name>A0A074ZN57_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169108.1">
        <property type="nucleotide sequence ID" value="XM_009170844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN57"/>
    <dbReference type="GeneID" id="20319946"/>
    <dbReference type="KEGG" id="ovi:T265_05764"/>
    <dbReference type="CTD" id="20319946"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28346" checksum="A8F276EFC728E2AD" modified="2014-10-01" version="1">MFELGESKPEIKSKRPSKSASLVKRQELSDKTSCIPLDVGVWVCRVFLTCRWRWSRSRVPASKLQARRHFVVFGSNKVTKRRNPDIPRTVLSSPIASKGAPDRALPECPVFVLMWKGEPPKGVREPRTPRLAIEKLVDPETKRNYQKQLLECLPDGTVSDINDHWEKISNALLKAGASACGTTQPTSSKHWISDRTVFSGDPATDPTWSPPQLHPAHHSTPGETECPRRPRSLVEEMEDAKNAGTLPLASDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQN6</accession>
    <name>A0A074ZQN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_13645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168130.1">
        <property type="nucleotide sequence ID" value="XM_009169866.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZQN6"/>
    <dbReference type="GeneID" id="20327812"/>
    <dbReference type="KEGG" id="ovi:T265_13645"/>
    <dbReference type="CTD" id="20327812"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1331"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="85"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="204"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="1615"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="1878"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="2064"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="2292"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2216"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2242"/>
            <end position="2251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER28132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2386" mass="262204" checksum="03BD5B770C4500A3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQP9</accession>
    <name>A0A074ZQP9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596770">
        <property type="protein sequence ID" value="KER25645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170603.1">
        <property type="nucleotide sequence ID" value="XM_009172339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQP9"/>
    <dbReference type="STRING" id="6198.A0A074ZQP9"/>
    <dbReference type="GeneID" id="20321115"/>
    <dbReference type="KEGG" id="ovi:T265_06936"/>
    <dbReference type="CTD" id="20321115"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="81284" checksum="E719694C81970017" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQY9</accession>
    <name>A0A074ZQY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168022.1">
        <property type="nucleotide sequence ID" value="XM_009169758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQY9"/>
    <dbReference type="GeneID" id="20319080"/>
    <dbReference type="KEGG" id="ovi:T265_04898"/>
    <dbReference type="CTD" id="20319080"/>
    <dbReference type="OrthoDB" id="6238847at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="551" mass="61998" checksum="9A76C1F6CAE15739" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR48</accession>
    <name>A0A074ZR48_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170420.1">
        <property type="nucleotide sequence ID" value="XM_009172156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR48"/>
    <dbReference type="GeneID" id="20320970"/>
    <dbReference type="KEGG" id="ovi:T265_06791"/>
    <dbReference type="CTD" id="20320970"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9238" checksum="F85DC71F8B0A2A39" modified="2014-10-01" version="1">MFSRVAVLSELGYTSKHSSPGWTLFIPQTIERQTITVRVTAQQDQTLPAFSGRGFPKKNRWHRRAEDPLKINVSYPEHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRD8</accession>
    <name>A0A074ZRD8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_13265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166278.1">
        <property type="nucleotide sequence ID" value="XM_009168014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRD8"/>
    <dbReference type="STRING" id="6198.A0A074ZRD8"/>
    <dbReference type="GeneID" id="20327432"/>
    <dbReference type="KEGG" id="ovi:T265_13265"/>
    <dbReference type="CTD" id="20327432"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="173"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER29983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="229" mass="26718" checksum="C19A1D67EFEA2F3A" modified="2014-10-01" version="1" fragment="single">QDIRIPYRTREDTFDLTDLKSLEPLKQFKEWFEDAVKSGLVYEANAMALATCTRSGIPSVRYVLLKELDERGFSFFTNYESRKAIELESNPNASLLFYWEPLHRQVRVEGTVTRLPEEESAEYFSKRPRQSQLAAMASPQSHVIPSRQSFVDSVKELENLYPEGETVPKPKNWGGYVLYPHTIEFWQGQSTRMHDRIRFRRITPEEQASIDPKITHLGEDGWVYERLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRT7</accession>
    <name>A0A074ZRT7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_06631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596758">
        <property type="protein sequence ID" value="KER26055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170208.1">
        <property type="nucleotide sequence ID" value="XM_009171944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRT7"/>
    <dbReference type="STRING" id="6198.A0A074ZRT7"/>
    <dbReference type="GeneID" id="20320810"/>
    <dbReference type="KEGG" id="ovi:T265_06631"/>
    <dbReference type="CTD" id="20320810"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER26055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="691" mass="77434" checksum="E42216D598D17A58" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS82</accession>
    <name>A0A074ZS82_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167565.1">
        <property type="nucleotide sequence ID" value="XM_009169301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS82"/>
    <dbReference type="STRING" id="6198.A0A074ZS82"/>
    <dbReference type="GeneID" id="20318719"/>
    <dbReference type="KEGG" id="ovi:T265_04537"/>
    <dbReference type="CTD" id="20318719"/>
    <dbReference type="OrthoDB" id="270568at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="86240" checksum="970859DFBC24A2CF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS83</accession>
    <name>A0A074ZS83_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170026.1">
        <property type="nucleotide sequence ID" value="XM_009171762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS83"/>
    <dbReference type="GeneID" id="20320667"/>
    <dbReference type="KEGG" id="ovi:T265_06488"/>
    <dbReference type="CTD" id="20320667"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="13766" checksum="A84464AF5138769D" modified="2014-10-01" version="1">MARHCHNQFDSTPVTVSFLLPTEPPCLLFPMTADTTNSPTDPNCLHDTLSNLLEYSFEFSHLCSITALGGREACCGRIKTAVRRRSCFIGLLSGAQGDMTTIGLVMSLGSAELVPSGSLFRASTPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU50</accession>
    <name>A0A074ZU50_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_02978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165621.1">
        <property type="nucleotide sequence ID" value="XM_009167357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU50"/>
    <dbReference type="STRING" id="6198.A0A074ZU50"/>
    <dbReference type="GeneID" id="20317166"/>
    <dbReference type="KEGG" id="ovi:T265_02978"/>
    <dbReference type="CTD" id="20317166"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="272"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1086"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER30626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125282" checksum="D5C78F15E05A9567" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU75</accession>
    <name>A0A074ZU75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165267.1">
        <property type="nucleotide sequence ID" value="XM_009167003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU75"/>
    <dbReference type="GeneID" id="20316889"/>
    <dbReference type="KEGG" id="ovi:T265_02701"/>
    <dbReference type="CTD" id="20316889"/>
    <dbReference type="OrthoDB" id="10033446at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053093">
        <property type="entry name" value="GPCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="627" mass="70595" checksum="A99AB659B3697E27" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUE4</accession>
    <name>A0A074ZUE4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166799.1">
        <property type="nucleotide sequence ID" value="XM_009168535.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZUE4"/>
    <dbReference type="GeneID" id="20318121"/>
    <dbReference type="KEGG" id="ovi:T265_03934"/>
    <dbReference type="CTD" id="20318121"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1292"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1468"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1577"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="900"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1986"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2001"/>
            <end position="2047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2826" mass="311208" checksum="0B2392A35830B181" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVZ8</accession>
    <name>A0A074ZVZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166178.1">
        <property type="nucleotide sequence ID" value="XM_009167914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVZ8"/>
    <dbReference type="STRING" id="6198.A0A074ZVZ8"/>
    <dbReference type="GeneID" id="20317617"/>
    <dbReference type="KEGG" id="ovi:T265_03430"/>
    <dbReference type="CTD" id="20317617"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="542" mass="59177" checksum="4EC429E47F3316B7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXV2</accession>
    <name>A0A074ZXV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164249.1">
        <property type="nucleotide sequence ID" value="XM_009165985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXV2"/>
    <dbReference type="GeneID" id="20316047"/>
    <dbReference type="KEGG" id="ovi:T265_01859"/>
    <dbReference type="CTD" id="20316047"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10117" checksum="D67D42823A2084D3" modified="2014-10-01" version="1">MSFGGDSANAFVMHGEKGPENIMRIDAKKDLGIRVSSNLSPLHHGKSAQKAFGILRMIRRTFSLGDPDGYEWFHSRDGEHLEQLFPKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXX0</accession>
    <name>A0A074ZXX0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168117.1">
        <property type="nucleotide sequence ID" value="XM_009169853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXX0"/>
    <dbReference type="GeneID" id="20319158"/>
    <dbReference type="KEGG" id="ovi:T265_04976"/>
    <dbReference type="CTD" id="20319158"/>
    <dbReference type="OrthoDB" id="10466180at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="11837" checksum="B334BB7F101B649E" modified="2014-10-01" version="1">MSAEGCTRAGILLGCSSLGRGSREAEVGFEPQTFRSVNSRPNHLGHLVPQLGVIQFNSIQFISYKPCVISTLVPAATVSITGKPESGTYNQAKACSVCSEIGSTLVEGDSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXX8</accession>
    <name>A0A074ZXX8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165403.1">
        <property type="nucleotide sequence ID" value="XM_009167139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20327250"/>
    <dbReference type="KEGG" id="ovi:T265_13082"/>
    <dbReference type="CTD" id="20327250"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1676" mass="187025" checksum="C15F3298C30D04A7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXX9</accession>
    <name>A0A074ZXX9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597100">
        <property type="protein sequence ID" value="KER20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176202.1">
        <property type="nucleotide sequence ID" value="XM_009177938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXX9"/>
    <dbReference type="STRING" id="6198.A0A074ZXX9"/>
    <dbReference type="GeneID" id="20325481"/>
    <dbReference type="KEGG" id="ovi:T265_11313"/>
    <dbReference type="CTD" id="20325481"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11579" checksum="996845A43B99CDF3" modified="2014-10-01" version="1">MSCVHLPSPVVSQVYPVEMLYEGPHDDEGGTGREKMVIQSVRYVSNTVPASDKGWFFSRVFAGATATGQTLGVTVNTMMCKPSFDKASYDRFCFDQTGSQQATLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY43</accession>
    <name>A0A074ZY43_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164167.1">
        <property type="nucleotide sequence ID" value="XM_009165903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY43"/>
    <dbReference type="GeneID" id="20315981"/>
    <dbReference type="KEGG" id="ovi:T265_01793"/>
    <dbReference type="CTD" id="20315981"/>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9376" checksum="BAF4EC0988CE23C7" modified="2014-10-01" version="1">MEAAGDPKAVLQDISKFDKSGLGHVVPEEKVVLPSAEEIQHEKTEKQLLEEITHHPKLRRASNLEKNPLPTPEVFAQEKKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYN9</accession>
    <name>A0A074ZYN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163738.1">
        <property type="nucleotide sequence ID" value="XM_009165474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYN9"/>
    <dbReference type="STRING" id="6198.A0A074ZYN9"/>
    <dbReference type="GeneID" id="20315636"/>
    <dbReference type="KEGG" id="ovi:T265_01448"/>
    <dbReference type="CTD" id="20315636"/>
    <dbReference type="OrthoDB" id="5596951at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625">
        <property type="entry name" value="LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625:SF0">
        <property type="entry name" value="PROTEIN LILIPOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="744" mass="82787" checksum="19E7F23DD39897AA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYS8</accession>
    <name>A0A074ZYS8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPSM family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597066">
        <property type="protein sequence ID" value="KER20339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175916.1">
        <property type="nucleotide sequence ID" value="XM_009177652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYS8"/>
    <dbReference type="STRING" id="6198.A0A074ZYS8"/>
    <dbReference type="GeneID" id="20325257"/>
    <dbReference type="KEGG" id="ovi:T265_11089"/>
    <dbReference type="CTD" id="20325257"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000043">
        <property type="entry name" value="G-protein-signaling modulator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="814"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER20339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="96131" checksum="B9C8856F35BF0E28" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0D4</accession>
    <name>A0A075A0D4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cysteine dioxygenase</fullName>
            <ecNumber evidence="3 11">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_02066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3 11"/>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164489.1">
        <property type="nucleotide sequence ID" value="XM_009166225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0D4"/>
    <dbReference type="STRING" id="6198.A0A075A0D4"/>
    <dbReference type="GeneID" id="20316254"/>
    <dbReference type="KEGG" id="ovi:T265_02066"/>
    <dbReference type="CTD" id="20316254"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="UniPathway" id="UPA00012">
        <property type="reaction ID" value="UER00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="9">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="228" mass="26306" checksum="8D7E079F10E9E39E" modified="2014-10-01" version="1">MQFEQRIVGNRMVNTRTTTDLGGSQVITLKQLGEELHRIFEHDFVDIDEVKQLLGSCTSDPLEWQSFAHFDKYRYTRNLVDAGNERFNLLILCWGEGHGTSIHDHDGSHCFLKVLAGEIRESLYAWPPGFDNSRLDSDIPPRLVRVSDFRFGDVTYIHDTIGLHRLENTSHTQKSVTLHVYCPPIRQSTMFDERTGRASKCKMTFYSQCGERRRPSLVEAPFTQQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0G6</accession>
    <name>A0A075A0G6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597009">
        <property type="protein sequence ID" value="KER20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175322.1">
        <property type="nucleotide sequence ID" value="XM_009177058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0G6"/>
    <dbReference type="GeneID" id="20329370"/>
    <dbReference type="KEGG" id="ovi:T265_15205"/>
    <dbReference type="CTD" id="20329370"/>
    <dbReference type="OrthoDB" id="6161345at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF153">
        <property type="entry name" value="SERINE PROTEASE HEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15417" checksum="4CF5008AC0316B69" modified="2014-10-01" version="1" fragment="single">MDPEAMRGDATRGDTMQPVPTELPDTHLQPPGLLPVRNSASQAVISTLCMASETNFHYEADDSLTFVDVAHVDKRIVGGTNVVQGTYTWAVKSTYLWSDQSISICSGSILSNKWILTAAHCCVHPHRQVIRSVIEAGNPNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0U9</accession>
    <name>A0A075A0U9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175224.1">
        <property type="nucleotide sequence ID" value="XM_009176960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0U9"/>
    <dbReference type="GeneID" id="20324726"/>
    <dbReference type="KEGG" id="ovi:T265_10558"/>
    <dbReference type="CTD" id="20324726"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="137" mass="15090" checksum="8FBDFFC063998C00" modified="2014-10-01" version="1">MINTTEVSATSEVGLKPNQAKASTNWLGVILTQPKLVKAGFGSVHKNHPEHSGARLLYMRTIVPDKLEQDLLISKSVDQVRLLAGMFFYVRALGSLENTNNTAIKVYIKIKLPGAPGSREKCPPAYKRTTLLDNFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A188</accession>
    <name>A0A075A188_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163185.1">
        <property type="nucleotide sequence ID" value="XM_009164921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A188"/>
    <dbReference type="GeneID" id="20315194"/>
    <dbReference type="KEGG" id="ovi:T265_01006"/>
    <dbReference type="CTD" id="20315194"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13589" checksum="0455EA3697F12D8D" modified="2014-10-01" version="1">MHARDGRDRQDEVTCDKTIQINITSGRSIPTPVFKTHTFHENHRLRIPQVLLHQFPKTPHEVCWTSQSPPTNSLGSMIVTETQLELDINDSDLSLSGLINQARLAVRNRRCYLPMRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1B8</accession>
    <name>A0A075A1B8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164203.1">
        <property type="nucleotide sequence ID" value="XM_009165939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1B8"/>
    <dbReference type="GeneID" id="20316017"/>
    <dbReference type="KEGG" id="ovi:T265_01829"/>
    <dbReference type="CTD" id="20316017"/>
    <dbReference type="OrthoDB" id="413835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12585" checksum="7D62FE00E580A3AE" modified="2014-10-01" version="1">MHVPTPNLEGQETVFVGPLPMDQPGMRNCVARTPPSIAQWVAEVHKPPHHGKVESLRCQWRSCCHQNRNVQMASDKNLVGLEYADDIVPIFEEKPQVFLNELTKAFCTHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1C3</accession>
    <name>A0A075A1C3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164208.1">
        <property type="nucleotide sequence ID" value="XM_009165944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1C3"/>
    <dbReference type="GeneID" id="20316022"/>
    <dbReference type="KEGG" id="ovi:T265_01834"/>
    <dbReference type="CTD" id="20316022"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="11122" checksum="202C6889A7DA25B7" modified="2014-10-01" version="1">MNLGPQADWSCPMPPGEKVTWERSDRPQIDTPNTHDCQSELAHIQRFRPNIVEKLFVLIDLATTLQIYNGRAISTDHIYNLVKEFRNIKPRIHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A218</accession>
    <name>A0A075A218_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162523.1">
        <property type="nucleotide sequence ID" value="XM_009164259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A218"/>
    <dbReference type="STRING" id="6198.A0A075A218"/>
    <dbReference type="GeneID" id="20326703"/>
    <dbReference type="KEGG" id="ovi:T265_12535"/>
    <dbReference type="CTD" id="20326703"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27736" checksum="F2F4111499190F72" modified="2014-10-01" version="1" fragment="single">MQLSKQQKRDFLVSELKVLRGLHHKNIVNYLDSFLRPQADELWVIMEYLDGGALTNVVMETIMDVPTMAAVTKECIQALVYLHDKNIIHRDIKSDNVLLGRRGQVKLTDFGFCAQLGSHHSQRMTMVGTPYWMAPEVLNKNVAYGPKVDVWSLGIMIIEMLDGEPPYNHLDPIKVILLIQTNNKPSPKTTPQDSSLKNFLERCLVFDADERASAKELLNHAFLRKAGPLTALIPLIEAANNARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2K2</accession>
    <name>A0A075A2K2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166486.1">
        <property type="nucleotide sequence ID" value="XM_009168222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2K2"/>
    <dbReference type="GeneID" id="20317867"/>
    <dbReference type="KEGG" id="ovi:T265_03680"/>
    <dbReference type="CTD" id="20317867"/>
    <dbReference type="OrthoDB" id="6254826at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="794" mass="85814" checksum="F7440B6352A92BD6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2V3</accession>
    <name>A0A075A2V3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162615.1">
        <property type="nucleotide sequence ID" value="XM_009164351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2V3"/>
    <dbReference type="GeneID" id="20314735"/>
    <dbReference type="KEGG" id="ovi:T265_00547"/>
    <dbReference type="CTD" id="20314735"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="277" mass="30605" checksum="75AF8483F7180CF1" modified="2014-10-01" version="1">MSPKKDETGRGLSADFQQPYKYCLRIPQTGDSAGFQVSISKNRISLQMNPLNPYPNPAESLVCCDVSGQLNVLHQATSCFSRYGIRDFAIHVYSPRVFVNLMIYFYPNWTAFEKYTHLQINLVLTGDSIESLVYDVLQLNVLHTGYLMFQLAQYSGYRVVIIGILIVPTNCIVRSPECISGACRSPKISVCCVKVCNSVHIPKVRRSNPTSATRLPLSRLGQPGSIPALVVPSGGMAARHRKGATAERFTPAPSPARQNASGINELSLNNIWVKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3B7</accession>
    <name>A0A075A3B7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162321.1">
        <property type="nucleotide sequence ID" value="XM_009164057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3B7"/>
    <dbReference type="STRING" id="6198.A0A075A3B7"/>
    <dbReference type="GeneID" id="20314500"/>
    <dbReference type="KEGG" id="ovi:T265_00312"/>
    <dbReference type="CTD" id="20314500"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="185"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="373" mass="41233" checksum="B4508C6741F03EE7" modified="2014-10-01" version="1">MVGLSAAAALKVAQHIVVISPDRDDQLASYGAPGGFRPDPSWMPGFACCATSKDGCSINCPLVRWCHKSKEHFWALAASQDAVNAGIFFQPMLDLYSEMLCRIPFAVKLCGSSKLLEMDEIQSLGFSSSIKWGYSFITCMIEGRYHMPYLREKLEHTSPLPVMFELESSCRKDSLDEVRKWANDNHIDVVVNCTGLGSATLCNDDLLIPVRGRLVRVAAPWLKFGIYSPNKAHAYIGRDSVIIGGYREPLPSPLIQPIRPEQAENSREATLNILERMGELWSGPLPSSRIVEEWTGFRPHRDILRLELAWLCDQNGGRSIPIIHNYGHGSMGISLSWGTALDVVYLVTQALKASTGSCTQGLLAPGLEKLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3I1</accession>
    <name>A0A075A3I1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161998.1">
        <property type="nucleotide sequence ID" value="XM_009163734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3I1"/>
    <dbReference type="STRING" id="6198.A0A075A3I1"/>
    <dbReference type="GeneID" id="20314265"/>
    <dbReference type="KEGG" id="ovi:T265_00077"/>
    <dbReference type="CTD" id="20314265"/>
    <dbReference type="OrthoDB" id="6220800at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043799">
        <property type="entry name" value="DUF5738"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19009">
        <property type="entry name" value="DUF5738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="823" mass="94340" checksum="0175FC2BEB06B6CC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3U9</accession>
    <name>A0A075A3U9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule-associated protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166027.1">
        <property type="nucleotide sequence ID" value="XM_009167763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3U9"/>
    <dbReference type="GeneID" id="20327373"/>
    <dbReference type="KEGG" id="ovi:T265_13206"/>
    <dbReference type="CTD" id="20327373"/>
    <dbReference type="OrthoDB" id="6285146at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026106">
        <property type="entry name" value="MAP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14739:SF9">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KER30220.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="56128" checksum="88F5AC409F0A011E" modified="2014-10-01" version="1" fragment="single">VDEVNRSIAELEQAKCPLGDVGQNPVVSQEFISMCQETLSDSREEKDITASRKAEIYPTTQLYPKPSELEFGLGDMTSARYSEQEQEEAIKDGKSPDTAERAMEPKPKLAVLHEDSEHSQQENVQKNTLGVQPVDLVQTPSPPAASTVRKSCVKESTAQPETAKPKKASSVESLTATARLTRSNSLSLPSPILKNADKQTSEPGVGPRSQVSTADKNNQHVRTLPSTKSSPRRPSSCHLGTFVEVPKQGANDAASMRMLAYREWYLKSQKSILEAKRVMSEKEAKEAERKLEALEKAQENEKMFMAWKSRKRAYFREQLKKKKEEEAARQKKAQETNERKASSEKAFEVWKSRKDAVLLKQAREKQEKQKLSKQTQQKEEEEKRTQAEKAFQAWRTKKEAELRELLHNQRQEQMQQERRKEEEMKQKSEKAAEAYYQWEMKKIASLGAMIIGHGFNQANSMENLRPTVTSGRMTERAPWRPASGRCSMTRGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A459</accession>
    <name>A0A075A459_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">28S ribosomal protein S30, mitochondrial</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">T265_00970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163149.1">
        <property type="nucleotide sequence ID" value="XM_009164885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A459"/>
    <dbReference type="STRING" id="6198.A0A075A459"/>
    <dbReference type="GeneID" id="20315158"/>
    <dbReference type="KEGG" id="ovi:T265_00970"/>
    <dbReference type="CTD" id="20315158"/>
    <dbReference type="OrthoDB" id="6041973at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039982">
        <property type="entry name" value="Ribosomal_mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13014">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="88586" checksum="9BD4D74DA844F4F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4H2</accession>
    <name>A0A075A4H2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162037.1">
        <property type="nucleotide sequence ID" value="XM_009163773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4H2"/>
    <dbReference type="STRING" id="6198.A0A075A4H2"/>
    <dbReference type="GeneID" id="20314304"/>
    <dbReference type="KEGG" id="ovi:T265_00116"/>
    <dbReference type="CTD" id="20314304"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF374">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="694"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1130" mass="127459" checksum="3AD7EE8FA5ED1FC9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
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                <person name="Seet Q."/>
                <person name="Wongkham S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
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                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11060" checksum="945310CC2F5307AA" modified="2014-10-01" version="1">MLSRDALGRTSPNDFRFTKQDKSAKGLSSWMKRPAMPAEHSAARLTVELLLVNESFFTFSGNPIDLQELFGDVGTLVRFANRALGVYVVSVDLRNVAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A682</accession>
    <name>A0A075A682_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_12508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="43"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="443" mass="47429" checksum="9442E46871C4CE8A" modified="2014-10-01" version="1" fragment="single">MAALRMNKTDSADQLAISNVDAKVEPSVDDQLSLQSSPLTKTPTPVVEDELMLSPKPRPVESAAATSTPAPSLTKNLDKNPESYSSIPADNSHKRGRPRAGRRGHGRRVITPRVSIISSLFQNPLRQRAPQSRPQPLKKIPDTRCSNQSTPKEPRPHDTQITEKNKPTAQTTIEKSKKVRKSTTAVSRHGRRPTAPPSSRSKPHSSTAVSLASNELESNSGLDISQTSPVSDTTEPMVDEVRARLLQMPENSPVQSRMEPFKGEDQQSTFRTLPFTGHNFAKIRSSSLKASNSLPSSPSSLDSTLSSSSSSLSKEEYPLINERPSIKLEHREGLSGSIEQFVPSVSTGALAEAKQTRSTPFSSSPSSSTLTLSTLSSISTAKQHTTAHSPVCSSTLHPSPTSNCPPPLLPLATSAFDVCSQDGLLSGSANSDSCAVIPPPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A720</accession>
    <name>A0A075A720_OPIVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596860">
        <property type="protein sequence ID" value="KER23214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173043.1">
        <property type="nucleotide sequence ID" value="XM_009174779.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20323041"/>
    <dbReference type="KEGG" id="ovi:T265_08862"/>
    <dbReference type="CTD" id="20323041"/>
    <dbReference type="OrthoDB" id="6257039at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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            <end position="781"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114824" checksum="469DEEDD712AC87B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A725</accession>
    <name>A0A075A725_OPIVI</name>
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        </submittedName>
    </protein>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20323017"/>
    <dbReference type="KEGG" id="ovi:T265_08838"/>
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    <dbReference type="OrthoDB" id="10018185at2759"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER23224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="14098" checksum="02EE25CDF7BE339F" modified="2014-10-01" version="1">MAANRCKWCSGCQLPSRLPEFVSRGKSWLYDSEASVLKTDVMVSMSAFYVKLDSNYLLSLSVDVCCISGTRIQDRTLFMHLKPSKTISDILHFTLRVPRGLGAMAHGIFGLHSTATMKVPHWTESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A847</accession>
    <name>A0A075A847_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164368.1">
        <property type="nucleotide sequence ID" value="XM_009166104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A847"/>
    <dbReference type="GeneID" id="20316154"/>
    <dbReference type="KEGG" id="ovi:T265_01966"/>
    <dbReference type="CTD" id="20316154"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16351" checksum="92C13F5C5B953C1C" modified="2014-10-01" version="1">MRIHPNDGGVGPLVYHSLAVNAPIGPLNNKPFTKSQRSDTSIERMVTSRLLSLCMSQQLRSLQEAQMWEPSIAWRIGETRHALGSLNISHIEAVAETLRIGLDGTDRARLTLPLCASKLLVAMLVMLVINGSSPGQRDAEITAMAQPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A862</accession>
    <name>A0A075A862_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164390.1">
        <property type="nucleotide sequence ID" value="XM_009166126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A862"/>
    <dbReference type="GeneID" id="20316176"/>
    <dbReference type="KEGG" id="ovi:T265_01988"/>
    <dbReference type="CTD" id="20316176"/>
    <dbReference type="OrthoDB" id="6219646at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704569" evidence="1">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10330" checksum="7D603DD1B459074E" modified="2014-10-01" version="1">MDHKSTQHLIVIGSQMFRSAQASMTNFIVVLLLVLCVSSGTHGFPHSLEHAADDANESYRRLEVPIRYGLWEGSNKRWFPIKEYRGGLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAN8</accession>
    <name>A0A075AAN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163373.1">
        <property type="nucleotide sequence ID" value="XM_009165109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAN8"/>
    <dbReference type="GeneID" id="20315336"/>
    <dbReference type="KEGG" id="ovi:T265_01148"/>
    <dbReference type="CTD" id="20315336"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="14998" checksum="4DDBBA0A1B8C4336" modified="2014-10-01" version="1">MATRHQSPQFLRLLQNKGASTVQKKRLCECRGTLSSIAQWIVEVRKPSHHGKVQSFRDGSIRYDVVNMYAESASDTGTGPSICVNTDASLPYNHDLIESLIVKKKIKVDGGGTWCWLNTIIPRCLHLQTFTQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAZ3</accession>
    <name>A0A075AAZ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171470.1">
        <property type="nucleotide sequence ID" value="XM_009173206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAZ3"/>
    <dbReference type="GeneID" id="20321812"/>
    <dbReference type="KEGG" id="ovi:T265_07633"/>
    <dbReference type="CTD" id="20321812"/>
    <dbReference type="OrthoDB" id="6237559at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="169" mass="19115" checksum="E5046F9E58AC9A59" modified="2014-10-01" version="1">MTSTTEVCIICLVQLVLYFICIIIGYLRLWAFRIQPTPHFDRLEDTGVIRSDKRIIVNPGALSAMLMYDPVFELDPPTFEEYAGVKTMRALAEKATRRLLRNSVTVTNLPVNLALLRRSLMMLDSISEPTEMPEERPVSGTVSPMGAVDAPTSPYPKPKTTKRRFLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACP3</accession>
    <name>A0A075ACP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162430.1">
        <property type="nucleotide sequence ID" value="XM_009164166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACP3"/>
    <dbReference type="STRING" id="6198.A0A075ACP3"/>
    <dbReference type="GeneID" id="20314581"/>
    <dbReference type="KEGG" id="ovi:T265_00393"/>
    <dbReference type="CTD" id="20314581"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="737" mass="79004" checksum="754C4CFDF6E413CC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACS1</accession>
    <name>A0A075ACS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162532.1">
        <property type="nucleotide sequence ID" value="XM_009164268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACS1"/>
    <dbReference type="STRING" id="6198.A0A075ACS1"/>
    <dbReference type="GeneID" id="20326712"/>
    <dbReference type="KEGG" id="ovi:T265_12544"/>
    <dbReference type="CTD" id="20326712"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8124" checksum="EEB60A27CEF4F5DB" modified="2014-10-01" version="1" fragment="single">MGDLNFRLDGLDKPTVEKLVDQKRFSELISHDQLSRSRRKKLIFIDFLEGDIDFPPTFKFDKGTDQYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACS9</accession>
    <name>A0A075ACS9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170649.1">
        <property type="nucleotide sequence ID" value="XM_009172385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACS9"/>
    <dbReference type="GeneID" id="20328343"/>
    <dbReference type="KEGG" id="ovi:T265_14177"/>
    <dbReference type="CTD" id="20328343"/>
    <dbReference type="OrthoDB" id="543859at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="322" mass="36452" checksum="00B1A4382BB387FE" modified="2014-10-01" version="1" fragment="single">VIWTTNSTDIFHDSVIRQCRYPWIRNYKFIYVKDECHAAREFALLSACSFLLVTMNILLILVTGYSVNKLKDMAPRSFTDETVRRFYQKDLPEVIGNYDCLHKLDAGDLAIRAYKEYLRVNQINPDQLSAEESKQIASDYCAVMQGVGRDQHIRTITAESGQEASQFLQSFIQRSEILAEGEVARIHGYPFGRLISDRNGSLAGGLPTGVYNNHHTIACNDFLFNNLSLGEIRGFNAFSATETLVNKPATLKRLRQLERLGERDDENAESIEMRHNPSSGLSVCSSQDQAQQQQVGKFHVVPTQLSMDRMESACEGEQIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADI6</accession>
    <name>A0A075ADI6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L45, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_12450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162130.1">
        <property type="nucleotide sequence ID" value="XM_009163866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADI6"/>
    <dbReference type="STRING" id="6198.A0A075ADI6"/>
    <dbReference type="GeneID" id="20326618"/>
    <dbReference type="KEGG" id="ovi:T265_12450"/>
    <dbReference type="CTD" id="20326618"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="9">
        <location>
            <begin position="125"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="312" mass="35614" checksum="ADC58C4C319AE420" modified="2014-10-01" version="1">MSSKIFAFAHLPLLATQPTRHIRHKPWLPKFRLIRQMQPWTGPIDLSAHRPPATAGETPAALRAHLRRNGLLPPLIFRDNPITIGHSGQVTDPYTPPEGDGHASVLSLRRVGLQSDSLLKKGKSYRDTLKIRRHEPTFNPKTFASEASEIYQEAHELLQDFKSNESRLLELVTEKAFSEMTKGLQFRTLRWQFIASLEPPRVVHIRTQELMSRDNLYGQVTVRFHSQQIMAIFDRFGRLLFGNPAVPVDVLEYVVLEKHISDEYGIWRLHAKIFPPRAPPLGALVPTHRLLSEQHVPSTELVQPPQLSTETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG67</accession>
    <name>A0A075AG67_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167825.1">
        <property type="nucleotide sequence ID" value="XM_009169561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG67"/>
    <dbReference type="STRING" id="6198.A0A075AG67"/>
    <dbReference type="GeneID" id="20318930"/>
    <dbReference type="KEGG" id="ovi:T265_04748"/>
    <dbReference type="CTD" id="20318930"/>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.460">
        <property type="entry name" value="ppGaNTase-T1 linker domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF126">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704611" description="Polypeptide N-acetylgalactosaminyltransferase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="349"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="441"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="861" mass="96923" checksum="257FCD9ABC39BE9F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGM6</accession>
    <name>A0A075AGM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair endonuclease XPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_04345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167330.1">
        <property type="nucleotide sequence ID" value="XM_009169066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGM6"/>
    <dbReference type="STRING" id="6198.A0A075AGM6"/>
    <dbReference type="GeneID" id="20318527"/>
    <dbReference type="KEGG" id="ovi:T265_04345"/>
    <dbReference type="CTD" id="20318527"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="12">
        <location>
            <begin position="730"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER28874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113981" checksum="1C5C5A25745A5997" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHC0</accession>
    <name>A0A075AHC0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166652.1">
        <property type="nucleotide sequence ID" value="XM_009168388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHC0"/>
    <dbReference type="GeneID" id="20318004"/>
    <dbReference type="KEGG" id="ovi:T265_03817"/>
    <dbReference type="CTD" id="20318004"/>
    <dbReference type="OrthoDB" id="6251117at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="413" mass="46291" checksum="09568EEF2FE99B25" modified="2014-10-01" version="1">MGVLHLSLSMLVAFDPDEGPRGLVLYSILSGDEGGQFELDANSGWIYLAQSLKHKRAATSPRQSSEPQLHSKMNHFSDKWTPASPTMLRLYVQASDCGTPPRSSSSVLDIIIQQSQSTPDSELSVQPQAREQTRRFGNSEEEKLLLSRSIFDLHKQHKWSRDQEQYGQRGLLVPSDFLTLIAMVTATLAALVLIFILFVVFRCRRLRIAEHVPSGHRTHPENVYKTSLAATTRNPPHSAEDCERHSFKQKCPSYAFWSRFGLHRHPARRVKHEPQQGGINDFRPPTTYAPIPILFPRIQGTLGSNKIGGQKYARICLNNSHNISKYMCDLPTSSDMQLLHTAAYGVCEFKQSPAQTSIGLPLDDTAEVMLCEENPLDVESKQNSAVNDYIPLRHILSKSKSEVNSLSQPSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHD9</accession>
    <name>A0A075AHD9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166542.1">
        <property type="nucleotide sequence ID" value="XM_009168278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHD9"/>
    <dbReference type="STRING" id="6198.A0A075AHD9"/>
    <dbReference type="GeneID" id="20317918"/>
    <dbReference type="KEGG" id="ovi:T265_03731"/>
    <dbReference type="CTD" id="20317918"/>
    <dbReference type="OrthoDB" id="6067523at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="289" mass="32724" checksum="F6FB5C30355B5937" modified="2014-10-01" version="1">MNVILLNLYCGSPNANVDSSPDFAFMIPASILFASQTQRNIENAGGNRKSPQLNAQQPTDLRSDHSDANNLRKSDADEDKPSAQMAISVDSAAASSQSVYAETDRKGSRKNPELPTTFYHCPQCPKRFTLPYVLGRHMNTHLKQKPYKCDFCPASFRLRVGKEGQMIQQHWKKLRASKNEGNARYSGLLKRERYASGMDVTSKDNYVIIFLKHEVDGGFHCVKRCFEDSLISQTADVFRVCRQMHTNDPVIISGHRKMKLVSRHHEHIEKYSTSNSHGSHLSRRLLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIJ9</accession>
    <name>A0A075AIJ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164547.1">
        <property type="nucleotide sequence ID" value="XM_009166283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIJ9"/>
    <dbReference type="GeneID" id="20316312"/>
    <dbReference type="KEGG" id="ovi:T265_02124"/>
    <dbReference type="CTD" id="20316312"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11308" checksum="D2A7D495ED42CE8D" modified="2014-10-01" version="1">MEIRDSGSDYGASCVPPRTTMESKGRHVPKEGTSASDRLCGIYGRDNVELPLLIEIQLDNLVLYFVHGVSPETTLNERLSRLFFGATGHRDASRTSAKLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIP5</accession>
    <name>A0A075AIP5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164312.1">
        <property type="nucleotide sequence ID" value="XM_009166048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIP5"/>
    <dbReference type="GeneID" id="20316110"/>
    <dbReference type="KEGG" id="ovi:T265_01922"/>
    <dbReference type="CTD" id="20316110"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9868" checksum="0AB42FBEF1E306BB" modified="2014-10-01" version="1">MYLRHLCSWYMTFLPRLLLDWDFPKSQSMTCVCSPFRALYVLTTPLCVVHDVECSLLRLTFTPDPCQSDEVNPKVCKDFGMGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIQ1</accession>
    <name>A0A075AIQ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164239.1">
        <property type="nucleotide sequence ID" value="XM_009165975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIQ1"/>
    <dbReference type="STRING" id="6198.A0A075AIQ1"/>
    <dbReference type="GeneID" id="20327041"/>
    <dbReference type="KEGG" id="ovi:T265_12873"/>
    <dbReference type="CTD" id="20327041"/>
    <dbReference type="OrthoDB" id="10069833at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39864" checksum="D4B7746A9BE1C08B" modified="2014-10-01" version="1" fragment="single">HTDISQVENLHKEASDTALVTSLRYFFRAGKMESGNKKLKTASPRKMSKDLGKAQSMSFPAKLYGQIQVMQPRGDEICEGSLALLKARLLITKNGKKQVSIEVLPSVIHIRERKVAEPIFTHFVNDITYVWTDITKNDVCGLIVKQPISDENSYLFFGYKMKSNSTKLIGALKHILMGHISAPLDVKAGSENETLIESEPGIGDLLNLDEVGADVVKPVPVGPLLIAPPNQLGIPKSTQNWTRFDDASDVEEFGPPHAPTDNPWETSQFPASTPSEKSRSNSDGSSPLPPYNPHPTTLQPLCQLMYSGLSPWCNYNNPYPCHSPTFWPSQTFGTGAIPSWLEYEKSTIDWVSGMHQAGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJH9</accession>
    <name>A0A075AJH9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162839.1">
        <property type="nucleotide sequence ID" value="XM_009164575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJH9"/>
    <dbReference type="STRING" id="6198.A0A075AJH9"/>
    <dbReference type="GeneID" id="20314914"/>
    <dbReference type="KEGG" id="ovi:T265_00726"/>
    <dbReference type="CTD" id="20314914"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="369"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="430"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="551" mass="61974" checksum="0B3062B649CAEF0E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTV7</accession>
    <name>A0A074YTV7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606037">
        <property type="protein sequence ID" value="KER18216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178037.1">
        <property type="nucleotide sequence ID" value="XM_009179773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTV7"/>
    <dbReference type="GeneID" id="20330379"/>
    <dbReference type="KEGG" id="ovi:T265_16214"/>
    <dbReference type="CTD" id="20330379"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="10757" checksum="6FB92945E049840C" modified="2014-10-01" version="1" fragment="single">DDGLRVLCTGLLQCYRNRLRQVHSEQPTVTGQEAVEDVSSISTDDCPSSFTHSSDEVSVCVRGLERLCVANNGLTASGMQIVALLLMQTPQRLVPLVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW66</accession>
    <name>A0A074YW66_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597379">
        <property type="protein sequence ID" value="KER19016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177236.1">
        <property type="nucleotide sequence ID" value="XM_009178972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YW66"/>
    <dbReference type="GeneID" id="20329864"/>
    <dbReference type="KEGG" id="ovi:T265_15699"/>
    <dbReference type="CTD" id="20329864"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14328" checksum="628C10CB77A10FDC" modified="2014-10-01" version="1" fragment="single">ANVFHTYHLLRANKLPAENIITFADIANNPENPFPGQVFHDTEHENIYKGVEIDYRGEEVNSEIFAKVLEGDTELEKQGKKVLKSGPGENVFIYYSGHGTIGYISFSNGKLSATQLNDILAKMRSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YX94</accession>
    <name>A0A074YX94_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597263">
        <property type="protein sequence ID" value="KER19268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176983.1">
        <property type="nucleotide sequence ID" value="XM_009178719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YX94"/>
    <dbReference type="STRING" id="6198.A0A074YX94"/>
    <dbReference type="GeneID" id="20326069"/>
    <dbReference type="KEGG" id="ovi:T265_11901"/>
    <dbReference type="CTD" id="20326069"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14700">
        <property type="entry name" value="bZIP_ATF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF3">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="356"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="914" mass="100441" checksum="4D8A46CD919621D9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXB3</accession>
    <name>A0A074YXB3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597207">
        <property type="protein sequence ID" value="KER19441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176810.1">
        <property type="nucleotide sequence ID" value="XM_009178546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXB3"/>
    <dbReference type="GeneID" id="20325954"/>
    <dbReference type="KEGG" id="ovi:T265_11786"/>
    <dbReference type="CTD" id="20325954"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12705" checksum="9AEF592027F1F6D4" modified="2014-10-01" version="1">MKCGALNTCCWKPVCVHFWKRLSNVVKPSISCTSSVIFLENVTVSATIVDMYGLARITVLDENPMLGKERPSRTGGTTVATTRMRASVTQNALPDYTIEPGRNQLLTIYGPIWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYD3</accession>
    <name>A0A074YYD3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606867">
        <property type="protein sequence ID" value="KER18192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178061.1">
        <property type="nucleotide sequence ID" value="XM_009179797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYD3"/>
    <dbReference type="GeneID" id="20330395"/>
    <dbReference type="KEGG" id="ovi:T265_16230"/>
    <dbReference type="CTD" id="20330395"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9473" checksum="4FD6CBF7ECC48262" modified="2014-10-01" version="1" fragment="single">AVCSVPSKPEHSCPSSRRLYATAFLLHQSTHGGSRLRHLLQPFRVYRFRSRPRRCRWSDSRPRNNVRTYRNSPGELTPQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYF1</accession>
    <name>A0A074YYF1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cwf18 pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176425.1">
        <property type="nucleotide sequence ID" value="XM_009178161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYF1"/>
    <dbReference type="STRING" id="6198.A0A074YYF1"/>
    <dbReference type="GeneID" id="20325660"/>
    <dbReference type="KEGG" id="ovi:T265_11492"/>
    <dbReference type="CTD" id="20325660"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19525" checksum="ADBDC23DEB2B7418" modified="2014-10-01" version="1">MTTVDLETADSDDSQTEEGPAEETEKSVGHLREEALQRKQRLLQLRKRKFRKLGDTGVEDAESELPKPVFRNYKPQSGDLKSGELPAAPPVDLTPYVTSQLEAANAPVIMEEVNLMSLAPRKPDWDLKRGVDKKLQKLERRTQRAIAELIRERLHNSESDLASRVNQQPAPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYK2</accession>
    <name>A0A074YYK2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_11575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597148">
        <property type="protein sequence ID" value="KER19728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176525.1">
        <property type="nucleotide sequence ID" value="XM_009178261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYK2"/>
    <dbReference type="STRING" id="6198.A0A074YYK2"/>
    <dbReference type="GeneID" id="20325743"/>
    <dbReference type="KEGG" id="ovi:T265_11575"/>
    <dbReference type="CTD" id="20325743"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER19728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="402" mass="45867" checksum="1D944F8BFA15B83E" modified="2014-10-01" version="1">MFQEEAYRSELLADLQADNTKFFCLVENNIESLAKTKSVDQYVKLQKIGQGTFGEVFKVRHKSTKQHFALKRIRMEQEKEGALNHENIVCLKEICHTAPNARNGYKPQFFLVFEFCDHDLAGLSQQVDFTDPVKKAIMKQLLTGLYYLHLNNILHRDLKAANILIDKNGILKIADFGLARTTVASIRPDRPTRYTTRVVTLWYRPPEILLNDRHYGKPVDLWGAGCIMAELWTKYPIMQGDNELNQLNLIINLCGSITPEVWPGVQRLESFREARLPQDIKRHVREKLTPKITSLAAVDLIDQLLVLDPSKRLDAEQALSHDYFYEDPPPGDLRSFSKSGTSYLEFLSSSNNPRGRAPPAMNRAGGPRGPGQQMNYIGAPGMPHPNRRPPMPDDSLYYDRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYV4</accession>
    <name>A0A074YYV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597111">
        <property type="protein sequence ID" value="KER19976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176280.1">
        <property type="nucleotide sequence ID" value="XM_009178016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYV4"/>
    <dbReference type="GeneID" id="20325545"/>
    <dbReference type="KEGG" id="ovi:T265_11377"/>
    <dbReference type="CTD" id="20325545"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16880" checksum="81267F086050DC1F" modified="2014-10-01" version="1">MESGPDKTCPKNKVPENGAVEMAQNCLQMTAHEQDSEWEDKQMVRKAAAYKTPGGQKRRRIPERKGYYHNNSEPCQRPRVPSTNEHARHSCETPEISVFDGVYPEMLCERWKHPRMLPCRVRLYSHLHGIKLIMQSRTRYNEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ74</accession>
    <name>A0A074YZ74_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_11279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597093">
        <property type="protein sequence ID" value="KER20096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176159.1">
        <property type="nucleotide sequence ID" value="XM_009177895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ74"/>
    <dbReference type="STRING" id="6198.A0A074YZ74"/>
    <dbReference type="GeneID" id="20325447"/>
    <dbReference type="KEGG" id="ovi:T265_11279"/>
    <dbReference type="CTD" id="20325447"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11427">
        <property type="entry name" value="bHLH_TS_NeuroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF134">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="449" mass="49805" checksum="0A84672418AF98D2" modified="2014-10-01" version="1">MEFNAPFELSISRTTGFPTMHVPVSAQICNLGSLAESEAYTTPLTYSPGFNGLPSCNADPRLLSGNQHSYVERVGDPPPGFKRYPRLLSGNQHSYVERVGDPPPGFKRLDISTSLVSGATSTDTKGTKKRKKKVTDPETDINEVKQPKKRGPKKKPLTKEREVRLKTRRVRANARERSRMHGLNHALELLRRHVPTFSATQRLSKIETLRLAKNYIHALSELLQRSEPPSPLELAFTLTEGLSQNTSNLIATKLQISPRALIQFQRKSTLTNESVSQQHTVAKVEYAAGETETRPTSQLPQSPLQENGPTINGCSLSPRSAYHTKQYENATVPNATMYNNVEQLSSTNSHFPLLSPVIQPSFEPNSYGEVPYQPIDSRLFSYEFAQQFAAPSTHFLYNPAHMTDLVCCSRSNSISSHCSDSLSPFPSNSDLVKTSIGLPIPGYLMPKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ83</accession>
    <name>A0A074YZ83_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597109">
        <property type="protein sequence ID" value="KER19988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176264.1">
        <property type="nucleotide sequence ID" value="XM_009178000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ83"/>
    <dbReference type="STRING" id="6198.A0A074YZ83"/>
    <dbReference type="GeneID" id="20329579"/>
    <dbReference type="KEGG" id="ovi:T265_15414"/>
    <dbReference type="CTD" id="20329579"/>
    <dbReference type="OrthoDB" id="5975444at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000003">
        <property type="entry name" value="Neuropilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF50">
        <property type="entry name" value="ATTRACTIN-LIKE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="130"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="242" mass="27236" checksum="B6CCE10079F74058" modified="2014-10-01" version="1" fragment="single">PICVYNLEGTTGEFKTPNYPLAYPDNLNCSWTIQSPGKSELIFQTFEIEESYVGEKCQFDVVYVHLQKGNDFETHGPLCGYSPPGPFEFDGKAVVTLTSDRIRAYSGFLAYFREEETEEQPAEPEGTARCGNDTTDSSGTITSPNFPNKYENNLGCSWTIQKPTKPSVLTFDSFDVEWANWGEQCQFDYLYVFVGTGRHVKSYGPYCGNQKPDPIPFDKPVQITFTTDDSERRTGFSLTFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZT2</accession>
    <name>A0A074YZT2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597086">
        <property type="protein sequence ID" value="KER20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176106.1">
        <property type="nucleotide sequence ID" value="XM_009177842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZT2"/>
    <dbReference type="GeneID" id="20325408"/>
    <dbReference type="KEGG" id="ovi:T265_11240"/>
    <dbReference type="CTD" id="20325408"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="14853" checksum="EC4DB8836E6A873D" modified="2014-10-01" version="1">MVFSDKNLHQGYRSAVAAIRCLTAMRPEGSTRARILPSCPSLDRESREAGVGFGPRTIRSSCLRSSNHMVFSDKNLHQGYRSAVAAIRCLTAMRPEGSTRARILPSCPSLDRESREAGVGFGPRTIRSVNLRPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z029</accession>
    <name>A0A074Z029_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597061">
        <property type="protein sequence ID" value="KER20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175853.1">
        <property type="nucleotide sequence ID" value="XM_009177589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z029"/>
    <dbReference type="GeneID" id="20325212"/>
    <dbReference type="KEGG" id="ovi:T265_11044"/>
    <dbReference type="CTD" id="20325212"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="329" mass="37074" checksum="E7E79FD9FBFED0D9" modified="2014-10-01" version="1">MEARLSTLNQQLSPTNSLPVSETNSLHTDVVDPPAERDAVTLLQNQLSAMSVRLLTAQDQIDRLLEEKRSWLNQPQSNKQMNSHHPSGELRGRLAQAQALAETYKREKENMVVKYAQSEQKRIELQNQLAALTKSTQQLSKSTPRGPQITTNGVDPSGNSDLSSSDSQELQAQLNQTTKLLNAARQEVDALRKGQKNDEARINTLEAKLGQMQETVRTEQRKTATQNETILRLNRSLEAASKQAKEAERLREREAERLCIEVAHKEAQEQVKRLQTECDTLRGQVSEMEQLKAKLSEQEAHLSKRLNGCVNVKLNVYASKSPIRKPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0H0</accession>
    <name>A0A074Z0H0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597058">
        <property type="protein sequence ID" value="KER20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175821.1">
        <property type="nucleotide sequence ID" value="XM_009177557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0H0"/>
    <dbReference type="GeneID" id="20325188"/>
    <dbReference type="KEGG" id="ovi:T265_11020"/>
    <dbReference type="CTD" id="20325188"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9327" checksum="8AAB13B1BF05FBE7" modified="2014-10-01" version="1">MLTIVDSWKAAELNKVDFFSDVSRKWARRSPGWQMLCKAVRKKVLSRKPGIKNTQKLRRSEQVAGLNVGLRPVAVAKFFAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z149</accession>
    <name>A0A074Z149_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597033">
        <property type="protein sequence ID" value="KER20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175584.1">
        <property type="nucleotide sequence ID" value="XM_009177320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z149"/>
    <dbReference type="GeneID" id="20329428"/>
    <dbReference type="KEGG" id="ovi:T265_15263"/>
    <dbReference type="CTD" id="20329428"/>
    <dbReference type="OrthoDB" id="6232687at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="274" mass="31511" checksum="FB96B3E83C2F59C6" modified="2014-10-01" version="1" fragment="single">ACHDTEELVIDGKYLELIDKSSSKSLSDRKVIPGLSLEVKSTQLGTTKPDALLFTISVTIDKNVKVPHITLTVDKEIIQRQAKKDLLRRRQLTPHRMDVRRYPIHFSPRPPMGRVKHDKKDSVERRLRCSDSVIVVPTESGSIRIPSCMPKISTVVKIRVAPTHSVLVIELDERAIPESVHVYCDLKQEIVRLVYDRAFVVNKLNSFYQQIVSNGHPWWEDEQSQQYELTTHVEHPFKFSTRDYVLSMARVKQNERTVLITVPLNDSNININVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1D3</accession>
    <name>A0A074Z1D3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597022">
        <property type="protein sequence ID" value="KER20778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175478.1">
        <property type="nucleotide sequence ID" value="XM_009177214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1D3"/>
    <dbReference type="GeneID" id="20324917"/>
    <dbReference type="KEGG" id="ovi:T265_10749"/>
    <dbReference type="CTD" id="20324917"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="25997" checksum="34029CF4C83336D4" modified="2014-10-01" version="1">MTCLNAGHIRSCFCGVPEHSSAFAKLIEVLTGQDACWLSNGDFGGVLGSHPHIRVSLLFELIGSARFEIRTSDMRGEGDTATPPTQVGRVRTFSSEQAMIGGKHWTRVSLLFELIGSAYPMAMPGFEPRTSDMRGERVTTTPPTHVGRIRIFTFEQEMSNANGLPDHPTVTGSSFDESGTPITLIKCEHVRLFRRDNSDASNVRWWNSGYTLASHDRCPGFESRHGHWICTADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4G4</accession>
    <name>A0A074Z4G4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596928">
        <property type="protein sequence ID" value="KER21958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174294.1">
        <property type="nucleotide sequence ID" value="XM_009176030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4G4"/>
    <dbReference type="STRING" id="6198.A0A074Z4G4"/>
    <dbReference type="GeneID" id="20329133"/>
    <dbReference type="KEGG" id="ovi:T265_14967"/>
    <dbReference type="CTD" id="20329133"/>
    <dbReference type="OrthoDB" id="6279307at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9052" checksum="BD02490249819FC6" modified="2014-10-01" version="1">MYGHYWWIMPLFVAISTSGCVNGTVMTTSRMFFAASQQNQMPKILSFLHVTHLTPIPSVVFTPENWASYSSCTCDLSGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4U1</accession>
    <name>A0A074Z4U1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174160.1">
        <property type="nucleotide sequence ID" value="XM_009175896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4U1"/>
    <dbReference type="GeneID" id="20323899"/>
    <dbReference type="KEGG" id="ovi:T265_09731"/>
    <dbReference type="CTD" id="20323899"/>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12625" checksum="F9E99FA3768F4FC8" modified="2014-10-01" version="1">MTSVLNTNASLPYNHDLFESLIVKKRIKCEALKGSLRMFCLRLHCIPTASFLNHSQSRRDISTAFHRMARRLNLRLSGYPLCWANSGTFFVSSKGSTDCNESHMSLNNATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z581</accession>
    <name>A0A074Z581_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173981.1">
        <property type="nucleotide sequence ID" value="XM_009175717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z581"/>
    <dbReference type="STRING" id="6198.A0A074Z581"/>
    <dbReference type="GeneID" id="20323770"/>
    <dbReference type="KEGG" id="ovi:T265_09602"/>
    <dbReference type="CTD" id="20323770"/>
    <dbReference type="OrthoDB" id="6222334at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41441" checksum="C852C06AFDE64381" modified="2014-10-01" version="1">MHEEENLALVIDNGSGMCKAGFAGDDAPRAVYPSVIGRPKLPGVMVGMGQKDVYIGDEAESKRGILTLHYPVENGIVNNWDDMERLWHHTFYNELRVAPEEHPVLLTEPPLNPKSNREKMAQILFESFSSPAMYVGIQAVLSLYASGRTTGVVMDSGDGVTHIVPVYEGYALSHAICRLDLAGRELTDYMVKLLRERGYAFITSAEREVVRDIKEQLCYVALDFESEMLDAPNLPHLEQTYGLPDGQVITLGNGRFRCPEVLFQPSIIGRETPGIHETLFISVMKSELDLRRDLFANIVLSGGSTLFSGMEDRLKKEISALTPPTVKVKFVCPPEPHKVTVLVMVIMMMTDRVGNIHDDQFISTPEVIHVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5C6</accession>
    <name>A0A074Z5C6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597026">
        <property type="protein sequence ID" value="KER20727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175514.1">
        <property type="nucleotide sequence ID" value="XM_009177250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5C6"/>
    <dbReference type="STRING" id="6198.A0A074Z5C6"/>
    <dbReference type="GeneID" id="20324949"/>
    <dbReference type="KEGG" id="ovi:T265_10781"/>
    <dbReference type="CTD" id="20324949"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="286" mass="32374" checksum="70776D5DE902B073" modified="2014-10-01" version="1">MESKNTKPVTSGSKVSSSFSIRQLLCLSEPPFDCEHPTTLYCSKKQPISNDSLTRADEVLDEPPSDPVTEHKSSSCCPPELLNRFVSFIQQQQQQQQQQEHSEKDHLLTSRPFMHHLWRFSELFGMDDACLENYNSKRNLLTPTTFVPNQSGDGLVKTSRQLSSHKTSSGLDATRCNSNILTGTLPESAANDLPPFFLHNNASTYASIPIFSRETSGKQYRRRKARTVFSDHQLLGLEHRFESQHYLSTPERIELANRLSLSETQVSKIFGGKNLILLLEIFSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5V6</accession>
    <name>A0A074Z5V6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596894">
        <property type="protein sequence ID" value="KER22521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173731.1">
        <property type="nucleotide sequence ID" value="XM_009175467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5V6"/>
    <dbReference type="GeneID" id="20323583"/>
    <dbReference type="KEGG" id="ovi:T265_09414"/>
    <dbReference type="CTD" id="20323583"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10591" checksum="B7F7C475536DB495" modified="2014-10-01" version="1">MDNNLGLEFGLEFGVAQVEAKKLQKLFEAGAQFILFRWQPERYFEDIGRNKLASLRSATLAIAYLPASIVLKKNQYTLLTVLLMEILNSAMAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Z1</accession>
    <name>A0A074Z7Z1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596951">
        <property type="protein sequence ID" value="KER21657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174607.1">
        <property type="nucleotide sequence ID" value="XM_009176343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Z1"/>
    <dbReference type="GeneID" id="20329212"/>
    <dbReference type="KEGG" id="ovi:T265_15046"/>
    <dbReference type="CTD" id="20329212"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9255" checksum="CCFC31039FCDB552" modified="2014-10-01" version="1" fragment="single">CPLPACALISDNRFSAEEIASSQVGTPRNGRAKELFDKQGCEAPMIQNSITLRIGLTVPSTAFTMWTCPPRDLHALLACSPGQTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8M1</accession>
    <name>A0A074Z8M1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172664.1">
        <property type="nucleotide sequence ID" value="XM_009174400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8M1"/>
    <dbReference type="GeneID" id="20322734"/>
    <dbReference type="KEGG" id="ovi:T265_08555"/>
    <dbReference type="CTD" id="20322734"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="351" mass="38699" checksum="22BCA32D989119C2" modified="2014-10-01" version="1">MAKWPLRSFTCSLYPTSGELPALNTFTPTPLGVCFQAVFDKLRQRTCYPGTDGDLGDASPSAHILFVSKRFLTECVLRHKREIQLSPPCEPNSYRNASVADHDDDDGGDDDVDDDDVDDDDDDDDDDDDDDDGDDEVDDETFAVQLPSSAIRPITIEYISVLAAAGSNRFLREISQPPEASSDEVDHDADDDADDDHDDGDDDDEEEEDEDEDDGDDDDDDYDDDDAEVDHGEDDDEDDDDDEFDDDADDDVIDDDDDDGDGDGDGDDRYSHFPQPSGSDVLVDTFSITVCPTGTLDTTDQARSDDKPAQTLRAEGSMSALICLLLKMHFTNRKSHLNMMASLVCGRLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8M4</accession>
    <name>A0A074Z8M4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172787.1">
        <property type="nucleotide sequence ID" value="XM_009174523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8M4"/>
    <dbReference type="GeneID" id="20328803"/>
    <dbReference type="KEGG" id="ovi:T265_14637"/>
    <dbReference type="CTD" id="20328803"/>
    <dbReference type="OrthoDB" id="6267990at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135057" checksum="A7F4F34CA6271CF7" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F2</accession>
    <name>A0A074Z9F2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596914">
        <property type="protein sequence ID" value="KER22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174075.1">
        <property type="nucleotide sequence ID" value="XM_009175811.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z9F2"/>
    <dbReference type="GeneID" id="20329094"/>
    <dbReference type="KEGG" id="ovi:T265_14928"/>
    <dbReference type="CTD" id="20329094"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF167">
        <property type="entry name" value="SIGNAL-REGULATORY PROTEIN BETA-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="444"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="584"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1510"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1679"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1708" mass="190077" checksum="A30F846BC7686D1C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9K5</accession>
    <name>A0A074Z9K5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596829">
        <property type="protein sequence ID" value="KER23916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172303.1">
        <property type="nucleotide sequence ID" value="XM_009174039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9K5"/>
    <dbReference type="GeneID" id="20322462"/>
    <dbReference type="KEGG" id="ovi:T265_08283"/>
    <dbReference type="CTD" id="20322462"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18795" checksum="9D6C2F7BCD4E480A" modified="2014-10-01" version="1">MNAKRMCYMDHSFFNKKTADWQSRCLAGWREKQTVSDSIISNSFVYNKQKSKGVYRKWAFKYTVDGKVRGSNTTSATRLPLSRLGHRGSILALVLPSGCIVVWYRKGDFQTSTLDEDFVLNLVFTKESTESLVYDILQLNVLHTGRLMFQLARRSRYLRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9S8</accession>
    <name>A0A074Z9S8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172369.1">
        <property type="nucleotide sequence ID" value="XM_009174105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9S8"/>
    <dbReference type="STRING" id="6198.A0A074Z9S8"/>
    <dbReference type="GeneID" id="20322516"/>
    <dbReference type="KEGG" id="ovi:T265_08337"/>
    <dbReference type="CTD" id="20322516"/>
    <dbReference type="OrthoDB" id="5559822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="21432" checksum="9ED4CE1022AB3570" modified="2014-10-01" version="1">MSCPLTSRNTNLESLNMVCLFCCILPGGADQKKVKIDPLSIGPPTGFRHVAHMGSGIQRESTMTLTDEFEEYDFPVHLKLIDLPVSAERKSSSPSGDSYMTSLAEPPVDQVFFSNNTDTSSSLQPEPREPAVLARRPVPTPNAFEIGSTSPGYSFPPSPQRCPSSAPARPDRNSNFSPLPPPPPPPTYRQFLRVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB91</accession>
    <name>A0A074ZB91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596805">
        <property type="protein sequence ID" value="KER24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171682.1">
        <property type="nucleotide sequence ID" value="XM_009173418.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZB91"/>
    <dbReference type="GeneID" id="20321977"/>
    <dbReference type="KEGG" id="ovi:T265_07798"/>
    <dbReference type="CTD" id="20321977"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1558"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2515"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2638"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2538"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2656"/>
            <end position="2670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2938" mass="331439" checksum="3C0109D24E25ED87" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBD0</accession>
    <name>A0A074ZBD0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_14426</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596810">
        <property type="protein sequence ID" value="KER24433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171830.1">
        <property type="nucleotide sequence ID" value="XM_009173566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBD0"/>
    <dbReference type="STRING" id="6198.A0A074ZBD0"/>
    <dbReference type="GeneID" id="20328592"/>
    <dbReference type="KEGG" id="ovi:T265_14426"/>
    <dbReference type="CTD" id="20328592"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER24433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="467" mass="52335" checksum="1111EA634CA53AE5" modified="2014-10-01" version="1" fragment="single">FVCVFICLQLSVLSTLKEHEKTAGILLFYLEMAMLFWFFAEYCIRVWCAGCRSRYQTWRGRLRFMHRPFCLVDATVIIASIVVLSMGTDSQRFAASPLRGLRFFQILRMIRMDRRGGSWKLLASVVWAHRQELFTTVYIGFLALISGSFLVYLLERDTNEKIRSYADALWWGVVTLCTVGYGDTVPKTWMGKIVAACCSVAGISFFALPAGILGSGFALKVQQHQREKHLIRRRVPAATLIQSLWRCYAADVNSTSVATWKVHMRALKTLSADQGEKGSSRLSRFATVRRLGLGNFVNVSSANNGEHDSSPTIVTSTSVPGTNRLASFSPLRCVTAESGHYEVRGNLIRNLSNTRTYNNLLNHVELRAKPQKPITSNGVHVDSEPRVYKLAKPRVNLNDTSDDKFKERFMFRSKTTSESVPEDQSTHDAVESDLNVGYGSTGSLGSKTTRSSSALKVRFQTLAHAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCF7</accession>
    <name>A0A074ZCF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL596856">
        <property type="protein sequence ID" value="KER23282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172965.1">
        <property type="nucleotide sequence ID" value="XM_009174701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCF7"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20322974"/>
    <dbReference type="KEGG" id="ovi:T265_08795"/>
    <dbReference type="CTD" id="20322974"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="38888" checksum="6C0EF8385A53E171" modified="2014-10-01" version="1">MELQLNRNMIIRCSLLIAFLFCISHVRWLEAIGVHNWSSIFNNNPSKTWVVLVAGSNTWNNYRHEADVYHAYQLVRKNKVPAENIITFAYDDIANNRKNPFKGKVFQDYQHKDVYTGVVIDYRGKDVTRDNFVRVLTGDEKLEANKRKVLKSGPDDNVFIFFSGHGATSVIVFRGEELYAMELNDTIAYMHSKKMFNKLVLYMDSCNSGSMFHDVLPSNMGIYVTTAANENEDSFAMFCLDKKIDVCLADEYSYEWLLDSDYKDIKTRTLEEQYEEVKRCTVFSHAMKYGEMAMGSLPVGKFQGQYDLYVHRNEGAIAVSVRRSIRYFELSIGLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE79</accession>
    <name>A0A074ZE79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172272.1">
        <property type="nucleotide sequence ID" value="XM_009174008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE79"/>
    <dbReference type="GeneID" id="20322439"/>
    <dbReference type="KEGG" id="ovi:T265_08260"/>
    <dbReference type="CTD" id="20322439"/>
    <dbReference type="OrthoDB" id="6275413at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="247" mass="28308" checksum="67C047EEBEEC3D58" modified="2014-10-01" version="1">MSANEIALLVVGILVDILIIIILFLISVCKFNDEIRFWYDSKMRETMPPYKKVADYLRGMEHESGGFKKREPSYSSSVSEMEPAYELLEERPTIVSAHERDRSLKSSHSGYTSPMRTFGIEQGDERKPAASLVHFYRSPSVRSPHHSLDLSQHEAPYHRGSEISPSKEKPQVARKARPRPPRRRGRTRRHPSSSAFLPISRAQWRERLLYKSDSGSSSPSGIKMRRVTAAPEICQTRTMPSWDPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEW6</accession>
    <name>A0A074ZEW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596942">
        <property type="protein sequence ID" value="KER21775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174483.1">
        <property type="nucleotide sequence ID" value="XM_009176219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEW6"/>
    <dbReference type="GeneID" id="20324150"/>
    <dbReference type="KEGG" id="ovi:T265_09982"/>
    <dbReference type="CTD" id="20324150"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17700" checksum="664FF69D87E6DE73" modified="2014-10-01" version="1">MMLGTKTQQRSLNHMGNTVDKVRWAAERQHSLISFIRLWLLSISVVVIFKNSISVLISNIYHSRSMVRRFPYIITTGMFFMSISSHILRFPHLTTINVHEQEVRRFVNVALPVIPHVFGRKLIVACHEMAHRGCTQTYNLLRHRAQSSGMRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF94</accession>
    <name>A0A074ZF94_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170305.1">
        <property type="nucleotide sequence ID" value="XM_009172041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF94"/>
    <dbReference type="GeneID" id="20320886"/>
    <dbReference type="KEGG" id="ovi:T265_06707"/>
    <dbReference type="CTD" id="20320886"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7874" checksum="951CA725C06C4407" modified="2014-10-01" version="1">MLGKSLFYSTDDDDDDDDDDDDDDDDDDDDDDGGGDEKEEEGEDSDDEYESEAHMVQWKGNRFERRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG45</accession>
    <name>A0A074ZG45_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596911">
        <property type="protein sequence ID" value="KER22210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174029.1">
        <property type="nucleotide sequence ID" value="XM_009175765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG45"/>
    <dbReference type="GeneID" id="20323803"/>
    <dbReference type="KEGG" id="ovi:T265_09635"/>
    <dbReference type="CTD" id="20323803"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7184" checksum="2BB0DD377D3A6A2A" modified="2014-10-01" version="1">MQQKRRNSEIEPSTVRSVPAKSRLKIKKSTAVLLHTEAFSDSPKESRGDSFIEPQQLGCLEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG75</accession>
    <name>A0A074ZG75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170005.1">
        <property type="nucleotide sequence ID" value="XM_009171741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG75"/>
    <dbReference type="GeneID" id="20320652"/>
    <dbReference type="KEGG" id="ovi:T265_06473"/>
    <dbReference type="CTD" id="20320652"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="6">
        <location>
            <begin position="510"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="752" mass="85498" checksum="5876D80B2867D81F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGC4</accession>
    <name>A0A074ZGC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169900.1">
        <property type="nucleotide sequence ID" value="XM_009171636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGC4"/>
    <dbReference type="GeneID" id="20320567"/>
    <dbReference type="KEGG" id="ovi:T265_06388"/>
    <dbReference type="CTD" id="20320567"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19084" checksum="7B533A3C8B92ACA1" modified="2014-10-01" version="1">MTVVLTSGTGQLYSQVCRGSSVHYVPRCGLCSCTASAHLISSSYSMVVPGFEPRTSDMRGKRATTTPPTPVTTHKVAKNSSTAHDRFRLSWGSSGRHSFRVSLKLMIYLNPNCTVFEEYTHFSYTILMPSCHATRRKHEGWDTARLPKPRQGKSRGSGRVRTTDLPVSKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHA8</accession>
    <name>A0A074ZHA8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171146.1">
        <property type="nucleotide sequence ID" value="XM_009172882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHA8"/>
    <dbReference type="STRING" id="6198.A0A074ZHA8"/>
    <dbReference type="GeneID" id="20321557"/>
    <dbReference type="KEGG" id="ovi:T265_07378"/>
    <dbReference type="CTD" id="20321557"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21201">
        <property type="entry name" value="CH_VAV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="145"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="344"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="78869" checksum="5B1A6444BED05AE8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHN5</accession>
    <name>A0A074ZHN5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169493.1">
        <property type="nucleotide sequence ID" value="XM_009171229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHN5"/>
    <dbReference type="GeneID" id="20320241"/>
    <dbReference type="KEGG" id="ovi:T265_06059"/>
    <dbReference type="CTD" id="20320241"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="23442" checksum="1F11BE7DDF91E427" modified="2014-10-01" version="1">MNQPIKCMKPTPQSKKETAESQQNNHTQNYPIECTQRTNQTQEIETTSDSQETNQTTRRPFPELPDTIEKLYDHGQKRRNSACTDDVTSIGDETFAIQLPSSATNNQLTFNCRSIQGRRRSSIIIDSMTSVFNTDASLPYNHDLFESLIVKKRLVAKFPVHTDLAFTRDSIESLVYDVLRLCVVHTGRLKFQLPRYSTYRSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI77</accession>
    <name>A0A074ZI77_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169621.1">
        <property type="nucleotide sequence ID" value="XM_009171357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI77"/>
    <dbReference type="STRING" id="6198.A0A074ZI77"/>
    <dbReference type="GeneID" id="20320346"/>
    <dbReference type="KEGG" id="ovi:T265_06164"/>
    <dbReference type="CTD" id="20320346"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF51">
        <property type="entry name" value="ANOCTAMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="8">
        <location>
            <begin position="215"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="745" mass="85453" checksum="E75A1F409E6ACE98" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIG5</accession>
    <name>A0A074ZIG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-5 cytosine-specific DNA methylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_14186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170679.1">
        <property type="nucleotide sequence ID" value="XM_009172415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIG5"/>
    <dbReference type="STRING" id="6198.A0A074ZIG5"/>
    <dbReference type="GeneID" id="20328352"/>
    <dbReference type="KEGG" id="ovi:T265_14186"/>
    <dbReference type="CTD" id="20328352"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43858" checksum="A46FF63F5DE582CF" modified="2014-10-01" version="1" fragment="single">CVCWSCTQELVECIVPSKVNISVVSQLDFQVVAAIDINDTANRVYRANFSHTHAPNRVLESLSIEEVTSFTADMWSMSPPCQPFTRLGNQKYEEDNRSTSFFYVLGLIAAIRPKFILLENVKGFEHTEPWRQFLKVLHNCGYRYQQFLLTPLQFGVPNCRLRYYLVASSSSDSASSGLFAPHVHDSSHANTIHIVPPADLPPLPGCECPVCLGHVNHITKPDENFDEYLPYCRPISDYLTQHQQHSNLDFLDDSCLRRYFHVLDIVRPCDHKSRCFTKGYQKRIEGTGSVLQTATDPLTGEEINAQWITARSDPETQMSLAKRLQLRFFHSREVANLLCFPQTYTFPEDVTEKQRIRLLGNSVNVLVVAHLIHWAFGGFSAQKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIG8</accession>
    <name>A0A074ZIG8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173142.1">
        <property type="nucleotide sequence ID" value="XM_009174878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIG8"/>
    <dbReference type="GeneID" id="20328873"/>
    <dbReference type="KEGG" id="ovi:T265_14707"/>
    <dbReference type="CTD" id="20328873"/>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13785" checksum="7D3EA38476CB489C" modified="2014-10-01" version="1" fragment="single">DSPFSWNAQLAEVCVITVLRVEKTTTLFFHASNKEIAQSVEIEFRLSAKVPPPQRLITRSTLRLLLQWPNQLKTYQLQELTRINASLAHALRVRVNPEVSASSLFIYDILQFFTSVNDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZII8</accession>
    <name>A0A074ZII8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trematode Eggshell Synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173145.1">
        <property type="nucleotide sequence ID" value="XM_009174881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZII8"/>
    <dbReference type="GeneID" id="20328876"/>
    <dbReference type="KEGG" id="ovi:T265_14710"/>
    <dbReference type="CTD" id="20328876"/>
    <dbReference type="OrthoDB" id="6247339at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012615">
        <property type="entry name" value="TES"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08034">
        <property type="entry name" value="TES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32663" checksum="E1E6C0FA69D575AB" modified="2014-10-01" version="1" fragment="single">GRDAVSTQCLRFVKFLAWKQRVNVALNYFNPKGKLTVYFIQPKRIVFSARPFSVSISLTSGYKRGYKFGLGEGRVATGRFYRGGYGDATGNEVSGYDYDLEGELSGSGSSTHAGRFGNQRHEEDDGFYTQGGSYYMSGKARRDDDYGITAGLKAKGNFYGTGTEGEGSQYEQVTTFRRGGGHDTKGKKKHYNEYNSYGQAMKYGDKKVANNFNLRGSLKAKGKFDGYGKSDVSSEFDKYGKYGYSGSSKGYGGRDVYGKLKGKSEYDAYGKLKGYGAQNDYSKYGRHADYDTLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIT7</accession>
    <name>A0A074ZIT7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_06904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170566.1">
        <property type="nucleotide sequence ID" value="XM_009172302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIT7"/>
    <dbReference type="STRING" id="6198.A0A074ZIT7"/>
    <dbReference type="GeneID" id="20321083"/>
    <dbReference type="KEGG" id="ovi:T265_06904"/>
    <dbReference type="CTD" id="20321083"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="22225" checksum="1AB4BCE9630B54E1" modified="2014-10-01" version="1">MPYHKLIPTDVMPTTTSITEQIPSEDPPPYSVIDPNLQVPENVRPPGGPTPVTSLGCFNGAAVERSSEAPGSSLSTSTLPNTSACYGSTLPPVVITAEPVSYQEHEVAGRDPYVTYCPQCFQMVLTRTDPQAGELTFICFIFLLCFIGPFALLVCLFDTCKDVAHFCPTAQNWTIIHWTFIPAAHHTLIFLLLQYVFLSNTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIW3</accession>
    <name>A0A074ZIW3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_05671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER27268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169000.1">
        <property type="nucleotide sequence ID" value="XM_009170736.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A074ZIW3"/>
    <dbReference type="STRING" id="6198.A0A074ZIW3"/>
    <dbReference type="GeneID" id="20319853"/>
    <dbReference type="KEGG" id="ovi:T265_05671"/>
    <dbReference type="CTD" id="20319853"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="197"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="644"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <end position="485"/>
        </location>
    </feature>
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    </feature>
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            <end position="662"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
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            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER27268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="730" mass="81259" checksum="7364E2FFEAA2D17B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ83</accession>
    <name>A0A074ZJ83_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170432.1">
        <property type="nucleotide sequence ID" value="XM_009172168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ83"/>
    <dbReference type="STRING" id="6198.A0A074ZJ83"/>
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    <dbReference type="KEGG" id="ovi:T265_06803"/>
    <dbReference type="CTD" id="20320982"/>
    <dbReference type="OrthoDB" id="6287771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9382" checksum="3F1BB5B4BA627AB1" modified="2014-10-01" version="1">MMRQTREDLQTPGVQILQSPHVPTPNLEGQETVFVRPLTIDQPGVGDCECRGTLSSMAQWIADVRKPSHHGKVQSLRDGLFLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ99</accession>
    <name>A0A074ZJ99_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">Suppressor of white apricot N-terminal domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">T265_08700</name>
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    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009174574.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZJ99"/>
    <dbReference type="GeneID" id="20322879"/>
    <dbReference type="KEGG" id="ovi:T265_08700"/>
    <dbReference type="CTD" id="20322879"/>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="975" mass="108819" checksum="4B956EF5C48FFF05" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK45</accession>
    <name>A0A074ZK45_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172517.1">
        <property type="nucleotide sequence ID" value="XM_009174253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK45"/>
    <dbReference type="STRING" id="6198.A0A074ZK45"/>
    <dbReference type="GeneID" id="20322625"/>
    <dbReference type="KEGG" id="ovi:T265_08446"/>
    <dbReference type="CTD" id="20322625"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="315" mass="34847" checksum="B4A96AAE032A5BB5" modified="2014-10-01" version="1">MKLNENGDGGQPCRTTFYGKAFGELTIHSHPRIAIHVPTPNLEDQETVFVRPLTIDQPGMRDSVSVARTPPSIAQWVAEVHKPPHHDKVQSLRDGGSDPRLLESVRLAVTPVRCLAAMPPEGSTRVGIIPGCPNLDRINLKSVINQRDKLQSPRVVGLLHVSAITEPWSTGGIQEAEVANQGLPLSFGGFLSPERYKHCGLEALIDHIKQKRISPTNWDLNPRCIAKNNAKVSDRTIGVDRTAFREKTYLPSLALSQIVKWRVARSYFASSLDHDIDEYKPQPSIDHNRCGRNGCPSNVKRSVTFARPGGTENAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKK6</accession>
    <name>A0A074ZKK6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168652.1">
        <property type="nucleotide sequence ID" value="XM_009170388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKK6"/>
    <dbReference type="GeneID" id="20319572"/>
    <dbReference type="KEGG" id="ovi:T265_05390"/>
    <dbReference type="CTD" id="20319572"/>
    <dbReference type="OrthoDB" id="6270617at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="20158" checksum="C096C5868451A656" modified="2014-10-01" version="1">MLKSYECTGRMNPVSAALWIGRMVSLSIVRFEGLWSPLIRCRAGILLVLLWLGCILGATLLAVFIFCTLWLYRVTRPAKNQEESFQMNQTMNGAHTVDDSKLATSAQRYHFEYQKRQMLSRTLSGDGDPSKSPDLKDDAKDTIYAYPGLGPTTPLELENPIYCEHAMDVVKSNQSDMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKV4</accession>
    <name>A0A074ZKV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169831.1">
        <property type="nucleotide sequence ID" value="XM_009171567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKV4"/>
    <dbReference type="STRING" id="6198.A0A074ZKV4"/>
    <dbReference type="GeneID" id="20320516"/>
    <dbReference type="KEGG" id="ovi:T265_06334"/>
    <dbReference type="CTD" id="20320516"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="28990" checksum="CEA7B5B33481736E" modified="2014-10-01" version="1">MLRVSMRSKLLTRLLKICQQPTTGFAPLGAHQVGTVPEFLVNTMFYLNPNMKLRRPLWRDFVNMVEFYLVSYIKILNRGHNLVDGLFAELGSWIANVSSPIEVASSPLNRAQTMSPRLVMKRLQSNSQARRTDQQPNSAPELPTFHNIAKRSQSQFQKDLKHIRCFANRTTYGLPRSVKQSQTNHNNGSKILFDSHPIEFIPRTQDTALNIDSPSLRAHHLFDSHPIEFILGTQDTALNIDEESSTAHHWFCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLA2</accession>
    <name>A0A074ZLA2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172095.1">
        <property type="nucleotide sequence ID" value="XM_009173831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLA2"/>
    <dbReference type="GeneID" id="20322297"/>
    <dbReference type="KEGG" id="ovi:T265_08118"/>
    <dbReference type="CTD" id="20322297"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="18010" checksum="C5C22BE69F9D06EA" modified="2014-10-01" version="1">MKVTGASMWVTRDWVVFLFKPSPTSTQAKLTSVRIFTLAETVTGKKFKSGRKTTFSGQMTKRSATDEFQRTKIINGCKQNSINSGFICFACSTISNNTTSPQQSLPDRLIFDSSILLLCYTINSAFCHFTFAPIPIQSRRFSRLTTATGLQCYDLHCQPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLC0</accession>
    <name>A0A074ZLC0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168355.1">
        <property type="nucleotide sequence ID" value="XM_009170091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLC0"/>
    <dbReference type="STRING" id="6198.A0A074ZLC0"/>
    <dbReference type="GeneID" id="20319341"/>
    <dbReference type="KEGG" id="ovi:T265_05159"/>
    <dbReference type="CTD" id="20319341"/>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="16860" checksum="2155A00B3A0BE12B" modified="2014-10-01" version="1">MNECAESDINRVRLCHLRTLPEFSGYGFSLRTDSKNDKQLIENVESNSPAERGKLISGDIILKINGKRPPLLSKFSEYEDLVAQAEKETIICEVQENTSNNSELTKAEKNLLRSDATTTNIVRNKKQQQSHIAGPGCVNHAMTDDQGRILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLS6</accession>
    <name>A0A074ZLS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171955.1">
        <property type="nucleotide sequence ID" value="XM_009173691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLS6"/>
    <dbReference type="GeneID" id="20328618"/>
    <dbReference type="KEGG" id="ovi:T265_14452"/>
    <dbReference type="CTD" id="20328618"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9108" checksum="644B53FEF47B6FC8" modified="2014-10-01" version="1" fragment="single">MCLSFGGCNILSVPICYTTRREHEGRDTARLPKRRQGKLRGRGQVGTTDISVRSTRAEIIPGCSSLNSSRDAPVGFETRIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM26</accession>
    <name>A0A074ZM26_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167818.1">
        <property type="nucleotide sequence ID" value="XM_009169554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM26"/>
    <dbReference type="GeneID" id="20318923"/>
    <dbReference type="KEGG" id="ovi:T265_04741"/>
    <dbReference type="CTD" id="20318923"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="347" mass="38135" checksum="A955F403F7A27956" modified="2014-10-01" version="1">MFKDCTFRSITLRWWLEHEFTGRKVRGSNPIPTSRLTLSRLGQAGSILALMLPLGGTAASRRKGVTAERLLFYYISLCGLEALVVAAAVSFTDDLGGGIGSCALQAGADKLSLFDRLWLSSTLHVVVRKEPLEEVGRLAYANKRVTKNGRQNECSSSWGAYVHRKKERKRSALKPFRCLAAMLPEGSTRTGILPGYPSLDRGSRVAEVGFEPRTFRSVNSGSNHLGHFAPVHRNWIQETNSSAVAPFRWLAVMPTEGGTRVGILPGCTSPERSSRDAELAFEPRTFRSNSKVKKAFSCSTLPVPNCHATRRKHEGWDTARLPKPRQGKSSGGGRIRTMDLPVSKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMW5</accession>
    <name>A0A074ZMW5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_04507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167526.1">
        <property type="nucleotide sequence ID" value="XM_009169262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMW5"/>
    <dbReference type="STRING" id="6198.A0A074ZMW5"/>
    <dbReference type="GeneID" id="20318689"/>
    <dbReference type="KEGG" id="ovi:T265_04507"/>
    <dbReference type="CTD" id="20318689"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="343"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="872" mass="97454" checksum="C2C65F80CD1D35C9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNL9</accession>
    <name>A0A074ZNL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <dbReference type="EMBL" id="KER27382.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
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                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="84" mass="10049" checksum="86C7096A188B64D6" modified="2014-10-01" version="1">MDTKEELHMFKQQLGCYSNQHKIDCYFIMEQSPQLGQISVQMYTELLWQCSLAVRVPSNKKYGTVMYEEMPDYKEETERREPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPE8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="182" mass="20102" checksum="AEA5351EADBEA954" modified="2014-10-01" version="1">MVTAAVDKGLDHAVKGGHDTDAFNDSSLLVAANANMQSAIIGSNVGFSSTGHNVEDGRCGRRLTLNNMILNGTPVHRTSRRKNSTNNMPCHGHVNGGRSVGQDNNYPKANGEAFVDIGSVYSYGKNPMLFPNTDLHVCLFLRQCGKVDESIRLWCWIHKIVLLLLHKELRRLYAQRFQNVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ86</accession>
    <name>A0A074ZQ86_OPIVI</name>
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    <organism evidence="2 3">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15841" checksum="3FADB18C59B44CC7" modified="2014-10-01" version="1">MARCVRSINSYWKALKQRYAQPPREAYVAFPLIAAQASIQSSKVPLVLKVYHLPQSSPAMQHLQERAGGYLFTGALPCNRRRADKRFGARAARNLIISGMNFARHIEESEILLAKGLSHLNTRNKKPRKQNPHKTEGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH4</accession>
    <name>A0A074ZRH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166268.1">
        <property type="nucleotide sequence ID" value="XM_009168004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH4"/>
    <dbReference type="GeneID" id="20317691"/>
    <dbReference type="KEGG" id="ovi:T265_03504"/>
    <dbReference type="CTD" id="20317691"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8219" checksum="9BA9D8B8D8FB4A33" modified="2014-10-01" version="1">MDGVCLRSNLQSQLGRYIKRDLLDKATCTMTMSPTSLDWRLSERKRVEKWITSCSEIVSRKNKPPNLFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG4</accession>
    <name>A0A074ZTG4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165827.1">
        <property type="nucleotide sequence ID" value="XM_009167563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG4"/>
    <dbReference type="STRING" id="6198.A0A074ZTG4"/>
    <dbReference type="GeneID" id="20317337"/>
    <dbReference type="KEGG" id="ovi:T265_03150"/>
    <dbReference type="CTD" id="20317337"/>
    <dbReference type="OrthoDB" id="6236246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71344" checksum="82A6F68A7BF8A970" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTL8</accession>
    <name>A0A074ZTL8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_15960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KL599503">
        <property type="protein sequence ID" value="KER18584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177669.1">
        <property type="nucleotide sequence ID" value="XM_009179405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTL8"/>
    <dbReference type="STRING" id="6198.A0A074ZTL8"/>
    <dbReference type="GeneID" id="20330125"/>
    <dbReference type="KEGG" id="ovi:T265_15960"/>
    <dbReference type="CTD" id="20330125"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER18584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29571" checksum="27BBB1ACAB41C720" modified="2014-10-01" version="1" fragment="single">MIKNGPCLNRKYVQQIVDFIRERITILPTVGIVCGSGFGKMASKMKNAQVLKYEDIPNFPRSTVVGHPGNLVFGEFGGKMVVVMQGRFHMYEGYERQHVSSTFQIYVFYQITIPIRVMKLLGVEILLLTNAAGGLNRSLKVGDLVCIKDHISFPGMSLNNVLVGPNDEDFGERFIAISDAYDSNLRSIFKKVVAEMNFSDVVKEGVYAHVGGPTYESPAECRMLLMIGADVVGMSTAPEVLVARHAGIRVFALSLVTNVSVLDEESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTM6</accession>
    <name>A0A074ZTM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain AAA 5 extension domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599428">
        <property type="protein sequence ID" value="KER18589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177664.1">
        <property type="nucleotide sequence ID" value="XM_009179400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTM6"/>
    <dbReference type="STRING" id="6198.A0A074ZTM6"/>
    <dbReference type="GeneID" id="20326392"/>
    <dbReference type="KEGG" id="ovi:T265_12224"/>
    <dbReference type="CTD" id="20326392"/>
    <dbReference type="OrthoDB" id="6144504at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="2">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13971" checksum="D63250B51994EF3A" modified="2014-10-01" version="1">MYGTLASFSDIPITQINVAKADKFSPQVPIARVQTMCKLLEVLLTNPNAPSMTQEKHKLNPILAMSFVFSLIWGLAGGTIDANWDQVDAFVRNVFDDVGDARVGLRVLIIEKSVLSLPLLINLTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV10</accession>
    <name>A0A074ZV10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_05728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169065.1">
        <property type="nucleotide sequence ID" value="XM_009170801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV10"/>
    <dbReference type="STRING" id="6198.A0A074ZV10"/>
    <dbReference type="GeneID" id="20319910"/>
    <dbReference type="KEGG" id="ovi:T265_05728"/>
    <dbReference type="CTD" id="20319910"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="509" mass="58086" checksum="2C452F2C929F7869" modified="2014-10-01" version="1">MSDGSCISSDCSVVTDEVNERICKARAAFANLRHLWRQKGLSVNLKERVYQAIVRAVLLYGCETWSIRAAELRRLQVFDNRRLRTIARVTSVWLTVAFTGDRYLMICHPFFAKRWCTVRVTRISIVIIYLMSVVYGIPRYFEYRGFEVYVPKSNPIEDEGLLESLPLSEHFQRIVWYDLTEFGSSSQFRTFYHLWSWNILVVALPFVSIAVMNSFLICEVRRSRTRNVKQNLQKVSRRQDTNIMLIGVIVVFFICQTPAAISHFSWGVIPLADMTKLPWYLLNEIGNLLVVVNSAINLVPYYLFSRRFRRQFTLLFCPYRIIRDDGLHCVYVPRWIADHWEKDLSDNWISTADGAGPTGAGPAGDGTGGGGGRSAPVPLNARLIAYHRRQSTMHSIRPSVSSAPFGKSSLRPSGGRTDRTFSNGQRVSSGIGLQTRHHSGSREGSFGLALTPRGSRNKQLMQQRRQTQQQQIRQAGLQECNQSNDFTTRLHRSLDSRDVQPVVFVHNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVZ0</accession>
    <name>A0A074ZVZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168695.1">
        <property type="nucleotide sequence ID" value="XM_009170431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVZ0"/>
    <dbReference type="GeneID" id="20319606"/>
    <dbReference type="KEGG" id="ovi:T265_05424"/>
    <dbReference type="CTD" id="20319606"/>
    <dbReference type="OrthoDB" id="10564813at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11276" checksum="D12CC286DB8D2BC1" modified="2014-10-01" version="1">MSSEIDKTGCGLMECFQQPCEQFLLDAPRHEKKHVRRMTYPQGRHRYYTFRVGGALAELTEHGLATYDQWSGAEIRLDRNTTIGYTERTSERSYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW02</accession>
    <name>A0A074ZW02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168705.1">
        <property type="nucleotide sequence ID" value="XM_009170441.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZW02"/>
    <dbReference type="GeneID" id="20319616"/>
    <dbReference type="KEGG" id="ovi:T265_05434"/>
    <dbReference type="CTD" id="20319616"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
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                <person name="Nagarajan N."/>
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                <person name="Maleewong W."/>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX82</accession>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER27965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="307" mass="34555" checksum="145C4E6980C5A6E3" modified="2014-10-01" version="1">MAQLVRARIDRKSVVRPRTSALDFPCLCLGNLANNQLNSVMDLMRRLPPQKIDRTLLDIISLAPDLCEDILSSIDQPLKIARDNKAGRDYLLCDYNRDGDSYRSPWSNTYDPPLEDGAMPSENLRKREIEINAAFDQYREMYYEGGISSVYLWDMEQGFAGVILIKKAGDAKLASGCWDSIHVIDVIERSSAKVAQYKLTSTVMLWLQTQRESAGYFNLGGSLTRFMERDGPLGDAGQSITTSHIVNIGRMVEDAENSIRSTLNEVYFGTTKNIVDSLHSIVPASEEEKRRRLVQEVHTALQNKSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX89</accession>
    <name>A0A074ZX89_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164642.1">
        <property type="nucleotide sequence ID" value="XM_009166378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX89"/>
    <dbReference type="GeneID" id="20327112"/>
    <dbReference type="KEGG" id="ovi:T265_12944"/>
    <dbReference type="CTD" id="20327112"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="23227" checksum="0200AC9FD1F85ADA" modified="2014-10-01" version="1">MVSIPGWRRCEIWLQSDVNGVNDDVDADHARYPVKRGFRSKLSLPKILPDRFPQVFVYASPVIRKPPQPALTQLVPIKTIELKILYLDRCPRFDAVRLATSVSIAHEVTHRRSLYIVLACDPTECSPDTNKHSFYDASTQCSDRRRTHISLFNLVDILDYNRNAWTTAKACSTCVLTETAKFAWLHAAPAYNPNSNTDRPHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXD1</accession>
    <name>A0A074ZXD1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165709.1">
        <property type="nucleotide sequence ID" value="XM_009167445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXD1"/>
    <dbReference type="STRING" id="6198.A0A074ZXD1"/>
    <dbReference type="GeneID" id="20317243"/>
    <dbReference type="KEGG" id="ovi:T265_03056"/>
    <dbReference type="CTD" id="20317243"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="5">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11753" checksum="A21CD02DB126B776" modified="2014-10-01" version="1">MSDILLAEYTLKRALREHTTDLIPTTNPHILCTPLPKHWRSNKSLPSQFRVVSLTNIPDGTRVSVTAGNEERPYAELKNPVTIMHANEARFSDLRFLGRSGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXH6</accession>
    <name>A0A074ZXH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168196.1">
        <property type="nucleotide sequence ID" value="XM_009169932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXH6"/>
    <dbReference type="GeneID" id="20319214"/>
    <dbReference type="KEGG" id="ovi:T265_05032"/>
    <dbReference type="CTD" id="20319214"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="15192" checksum="7AB5C5D6E2739841" modified="2014-10-01" version="1">MVQNSEYFLTNGNVNRHLPCDANTIKQDVEVPRVLGANLQNAYWITQTTSDRCIQHVLRKIPIFKAIWFSREATESLVYGILQMNVLHTDRLMFQLARYSRYRRVAGNSSEGASRRLKSLSQESLKHKRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXQ2</accession>
    <name>A0A074ZXQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165527.1">
        <property type="nucleotide sequence ID" value="XM_009167263.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZXQ2"/>
    <dbReference type="GeneID" id="20327278"/>
    <dbReference type="KEGG" id="ovi:T265_13110"/>
    <dbReference type="CTD" id="20327278"/>
    <dbReference type="OrthoDB" id="6022401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="123"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="218"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="432"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="766"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1792" mass="200823" checksum="EEB8C75B088FDFDC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY31</accession>
    <name>A0A074ZY31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163906.1">
        <property type="nucleotide sequence ID" value="XM_009165642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY31"/>
    <dbReference type="GeneID" id="20315771"/>
    <dbReference type="KEGG" id="ovi:T265_01583"/>
    <dbReference type="CTD" id="20315771"/>
    <dbReference type="OrthoDB" id="5964980at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="477"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="759" mass="81677" checksum="C2A2BC331286C166" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY51</accession>
    <name>A0A074ZY51_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168026.1">
        <property type="nucleotide sequence ID" value="XM_009169762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY51"/>
    <dbReference type="GeneID" id="20319084"/>
    <dbReference type="KEGG" id="ovi:T265_04902"/>
    <dbReference type="CTD" id="20319084"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12136" checksum="22C2CC426531B212" modified="2014-10-01" version="1">MQEIESILLTNNTLREKHMGHVDALAGTPARMLTRKQPHRRTNLLPNRRLLPKVSKPDDTRAGLSTPPGQHRHPEHKDAQPSTSKSIYSSRIFSTLKPGSAKGLSTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYY8</accession>
    <name>A0A074ZYY8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isobutyryl-CoA dehydrogenase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acyl-CoA dehydrogenase family member 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_11033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = acryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:31287"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57367"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597060">
        <property type="protein sequence ID" value="KER20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175840.1">
        <property type="nucleotide sequence ID" value="XM_009177576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYY8"/>
    <dbReference type="STRING" id="6198.A0A074ZYY8"/>
    <dbReference type="GeneID" id="20325201"/>
    <dbReference type="KEGG" id="ovi:T265_11033"/>
    <dbReference type="CTD" id="20325201"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="35163" checksum="377455B50114A81F" modified="2014-10-01" version="1">MEEISRASGSVGLSYGAHSNLCVNQLVRHATEEQAKKYLPGLISGDLIGALAMSEVDSGSDVVSMKTRADRVGDNYVLNGSKFWITNGTVADVVIVYARTDTNSSDSRRGISTFIVETSTPGFSVGKKLKKLGMRGSPTSEIIFEDCVVPSSNLLGKLNEGLHVLMSGLDIERLVLAAGPVGLMQAACDVAFHYAQQRHAFGKPISEFGLIQGKMADMYTRLQVSRVYLYTLARVMDEIENGGSQLRIGQKAGPVNMECANLILHNAEAATQVALDAIQILGGNGYTEDYPVGRILRDAKLYEIGAGTSEIRRMIVARAINAQCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZY2</accession>
    <name>A0A074ZZY2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175553.1">
        <property type="nucleotide sequence ID" value="XM_009177289.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZY2"/>
    <dbReference type="GeneID" id="20329421"/>
    <dbReference type="KEGG" id="ovi:T265_15256"/>
    <dbReference type="CTD" id="20329421"/>
    <dbReference type="OrthoDB" id="6268628at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1409" mass="162461" checksum="40B68E7BE0AB1038" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A065</accession>
    <name>A0A075A065_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163531.1">
        <property type="nucleotide sequence ID" value="XM_009165267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A065"/>
    <dbReference type="GeneID" id="20326912"/>
    <dbReference type="KEGG" id="ovi:T265_12744"/>
    <dbReference type="CTD" id="20326912"/>
    <dbReference type="OrthoDB" id="6265111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33762" checksum="576E711E53289E87" modified="2014-10-01" version="1" fragment="single">DIRLIRLKEINDRVLLEKQIKQRQFLRKEQKRARLFNHIVAEISAECLEQEELVPHPDYTCPPCSPLPLSSDATGRSTISTGFTRRFDEEKVANSARSLQLYSYPHFVANARKVATAKTERETNRVRPQIGRRAFARLERQRVRAKCQILEDTLISERIKESAEKDFLSKIEQTVNSSEPDHEFLSKSPSESEPECSTVARLSTVTCLHNEEEDPPTPETDESSILNEEVLKMWQDLMRQMKIPLPTLCLCSRYIRSTATIPPWLSCADNCPYFHRPEAYLKALLDYIHSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0W5</accession>
    <name>A0A075A0W5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164383.1">
        <property type="nucleotide sequence ID" value="XM_009166119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0W5"/>
    <dbReference type="STRING" id="6198.A0A075A0W5"/>
    <dbReference type="GeneID" id="20316169"/>
    <dbReference type="KEGG" id="ovi:T265_01981"/>
    <dbReference type="CTD" id="20316169"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57655" checksum="EC7D82BFA50A7B05" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Y6</accession>
    <name>A0A075A0Y6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164323.1">
        <property type="nucleotide sequence ID" value="XM_009166059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Y6"/>
    <dbReference type="STRING" id="6198.A0A075A0Y6"/>
    <dbReference type="GeneID" id="20327052"/>
    <dbReference type="KEGG" id="ovi:T265_12884"/>
    <dbReference type="CTD" id="20327052"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="490" mass="55424" checksum="B5F418F2E6575A79" modified="2014-10-01" version="1" fragment="single">NGAESNQSISNAGSRTSLGRWLVCSFHIHQNIPFQVLILPILDMQTHYVRPRDSVISLLLACTPMVCSLKKTTSVLDEIKLHKGPPVFSEQERYRLIGAIKWVDQLVEGAPYVTTLETLRKHSCDFAAHGDDVTFTSDGSDPYHMVKVAGCYKEFKRTEGISTTELLSRILKRMESLEENQVHSGSPHRVKPLRRSRSVDSFLVTSLASLQNQTTPSETNQNHAAVTTAESPTQSDFGWTNCGIPYMPNTLRITQFSMGSLDSYGLREPGPDDVVVYAPGAFDLFHIGHLSFLEKCLDLGNYILIGLHSDSLLVINRVTFYFFPFGRLLRMKTADWGLSLLYRNDYSQFWPVEGFLLPPILNSLFIFCFETFDGYCFINFPFSSQYVCNVVIDAPYKITGRFLDHFKVNYVVVGKDTELRLLTNGEDPMKIPKQRGIFRRIDSGSDVTTSSVVARILKNRFDYEKRNRSKEARESEAITSLNRTSEGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I2</accession>
    <name>A0A075A1I2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162651.1">
        <property type="nucleotide sequence ID" value="XM_009164387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I2"/>
    <dbReference type="GeneID" id="20326731"/>
    <dbReference type="KEGG" id="ovi:T265_12563"/>
    <dbReference type="CTD" id="20326731"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="21269" checksum="C8023F32947CFA97" modified="2014-10-01" version="1" fragment="single">SSGTAKHNSPQLKERILWESLYRQEFYKTARDYLHTRIQRFLHDAEAIQMISLNRPTKSPGYSTGVRRDGPSGLGNLAVSLPSCFLLVAWPLGTKRVLQLNDYYYYSAVSERKRLTEGNTIARFQQSGCESASACECEKYNGLKHFIGRTLPELGPMLTHAVWLWYEAATCCILRRRCLTLINADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A200</accession>
    <name>A0A075A200_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164057.1">
        <property type="nucleotide sequence ID" value="XM_009165793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A200"/>
    <dbReference type="GeneID" id="20327000"/>
    <dbReference type="KEGG" id="ovi:T265_12832"/>
    <dbReference type="CTD" id="20327000"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11491" checksum="D459CEF263D8E457" modified="2014-10-01" version="1" fragment="single">GKQQDCTSQPNNLNHDVHHGAVQKPKYFSAVMVRRWNTRFDSIPAIVPLLLCLGPLAHWSPCRQTQSTFICPRPPPEGLASMRKLSGLLGEMMDEQHPVKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A252</accession>
    <name>A0A075A252_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168410.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A252"/>
    <dbReference type="GeneID" id="20327503"/>
    <dbReference type="KEGG" id="ovi:T265_13336"/>
    <dbReference type="CTD" id="20327503"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1615"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1859" mass="206720" checksum="BD26BB4060FE0ECE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A290</accession>
    <name>A0A075A290_OPIVI</name>
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        <recommendedName>
            <fullName evidence="7">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166667.1">
        <property type="nucleotide sequence ID" value="XM_009168403.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A290"/>
    <dbReference type="GeneID" id="20318019"/>
    <dbReference type="KEGG" id="ovi:T265_03832"/>
    <dbReference type="CTD" id="20318019"/>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF11">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705419" description="C-type lectin domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="2391"/>
            <end position="2473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2553" mass="287644" checksum="B400BB570E828559" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2V6</accession>
    <name>A0A075A2V6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162203.1">
        <property type="nucleotide sequence ID" value="XM_009163939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2V6"/>
    <dbReference type="GeneID" id="20314419"/>
    <dbReference type="KEGG" id="ovi:T265_00231"/>
    <dbReference type="CTD" id="20314419"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8692" checksum="EAEBCB1D2AF237FA" modified="2014-10-01" version="1">MTIDVFGASPESGGNTGSAILKSIIFYFILDGQITDLKEAEEQRFQVSGQTRQVEQRPSDRQQVNTPELPMFRRTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Z5</accession>
    <name>A0A075A2Z5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual specificity phosphatase, catalytic domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162436.1">
        <property type="nucleotide sequence ID" value="XM_009164172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Z5"/>
    <dbReference type="STRING" id="6198.A0A075A2Z5"/>
    <dbReference type="GeneID" id="20314587"/>
    <dbReference type="KEGG" id="ovi:T265_00399"/>
    <dbReference type="CTD" id="20314587"/>
    <dbReference type="OrthoDB" id="9979246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28953" checksum="60E69522ACF65EE4" modified="2014-10-01" version="1">MGGGLSKIIPGIYVGGLAAARSQMQLEKHHITHICTVLQNTVEFSRWSKIPNRKQIVFRADDSPSEDLSKFFEDACFFIHEARVADGAVLIHCACGVSRSVTITLAYLMVVTDFSLAELFKAVQGARHCACPNHGFMQQLLDFERSGRVAMLREKLFSRFGEWPAERRKQDTDALTAAIEAQEHFILHGVYPGEEPLDGLTPSAMHAADPEGKATNPDLPAPVGKLKHTVFTVYSDDKPRSLEEFIASRCPPEDVGTKAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Z6</accession>
    <name>A0A075A2Z6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Protein kinase C</fullName>
            <ecNumber evidence="2 15">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">T265_00253</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19">Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 15"/>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162225.1">
        <property type="nucleotide sequence ID" value="XM_009163961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Z6"/>
    <dbReference type="STRING" id="6198.A0A075A2Z6"/>
    <dbReference type="GeneID" id="20314441"/>
    <dbReference type="KEGG" id="ovi:T265_00253"/>
    <dbReference type="CTD" id="20314441"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05587">
        <property type="entry name" value="STKc_cPKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000023">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014375">
        <property type="entry name" value="Protein_kinase_C_a/b/g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000550">
        <property type="entry name" value="PKC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="343"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="602"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="349"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000550-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KER34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="672" mass="77675" checksum="F843240D61632322" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A351</accession>
    <name>A0A075A351_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163604.1">
        <property type="nucleotide sequence ID" value="XM_009165340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A351"/>
    <dbReference type="STRING" id="6198.A0A075A351"/>
    <dbReference type="GeneID" id="20315522"/>
    <dbReference type="KEGG" id="ovi:T265_01334"/>
    <dbReference type="CTD" id="20315522"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="191"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="577" mass="64111" checksum="449E389C40D3E313" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A385</accession>
    <name>A0A075A385_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174374.1">
        <property type="nucleotide sequence ID" value="XM_009176110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A385"/>
    <dbReference type="GeneID" id="20324066"/>
    <dbReference type="KEGG" id="ovi:T265_09898"/>
    <dbReference type="CTD" id="20324066"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="17178" checksum="2D3F3A944B7DAE68" modified="2014-10-01" version="1">MNAMREVEVACLFSFVHPKDPFFSEMAFGVAESWITNIRRRVSRRIEIFKTQFNLQPVPVPNMQPAKFIPSVISIYPPNTHEMQEMVFILMNSKPPNEKELSAELFRTLRRLLFYPIIDLLAKIWSLESISISRWKSIIFRSSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4B7</accession>
    <name>A0A075A4B7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgin subfamily A conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596910">
        <property type="protein sequence ID" value="KER22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174020.1">
        <property type="nucleotide sequence ID" value="XM_009175756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4B7"/>
    <dbReference type="STRING" id="6198.A0A075A4B7"/>
    <dbReference type="GeneID" id="20323795"/>
    <dbReference type="KEGG" id="ovi:T265_09627"/>
    <dbReference type="CTD" id="20323795"/>
    <dbReference type="OrthoDB" id="5978643at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043976">
        <property type="entry name" value="GOLGA_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15070">
        <property type="entry name" value="GOLGA2L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A conserved" evidence="4">
        <location>
            <begin position="643"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="432"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="572"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134573" checksum="6F684DB2C9907E52" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4H1</accession>
    <name>A0A075A4H1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596907">
        <property type="protein sequence ID" value="KER22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173961.1">
        <property type="nucleotide sequence ID" value="XM_009175697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4H1"/>
    <dbReference type="GeneID" id="20323756"/>
    <dbReference type="KEGG" id="ovi:T265_09588"/>
    <dbReference type="CTD" id="20323756"/>
    <dbReference type="OrthoDB" id="6239383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="18091" checksum="651FA30689CA1935" modified="2014-10-01" version="1">MKETVESAIATGQPDPLSDTNVLLTLYGGPYNQSTWDPMQIVDTLLADENKPAWEFSALIYQVFLYIMLSALLIGQALLLAREARKVIEYLIKRFFLGRKMTEFRVEDWNQIHLNRYTPFQVDYVKGSTEDYRLRLEDYRELLRMLSFIETHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5B7</accession>
    <name>A0A075A5B7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_02831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165439.1">
        <property type="nucleotide sequence ID" value="XM_009167175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5B7"/>
    <dbReference type="STRING" id="6198.A0A075A5B7"/>
    <dbReference type="GeneID" id="20317019"/>
    <dbReference type="KEGG" id="ovi:T265_02831"/>
    <dbReference type="CTD" id="20317019"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER30790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34636" checksum="4D954AF8F3A6BB31" modified="2014-10-01" version="1">MSCTIEMNFARLLHHTEDLATAEKANEIRFERYLVALQKLLRELLGSEQCPPTEYIRHYQSRLKQLELARELALSVNPEQRNLLLKSPAIPLIPRPVQDMALSLTTNPSAPDDGRTSSVNPQKRDMDSGVEIAQGSFSICGYIGDGPSLLKQEQKLQDRENREQLLGLNSNRSSPEPHKSSPTDEPPEKQRVARSQLLRKEEDHREELASEMLGMARQLKDQSTAMSHRLQSDRQTVEATIQQADRNTADMSKVLQQLSEELGSRCARIVWIALFIALVLFFQMIAFMKLFRKRTRSAISKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6R3</accession>
    <name>A0A075A6R3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173135.1">
        <property type="nucleotide sequence ID" value="XM_009174871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6R3"/>
    <dbReference type="STRING" id="6198.A0A075A6R3"/>
    <dbReference type="GeneID" id="20323111"/>
    <dbReference type="KEGG" id="ovi:T265_08932"/>
    <dbReference type="CTD" id="20323111"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000622">
        <property type="entry name" value="ATP-binding cassette sub-family G member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF116">
        <property type="entry name" value="PROTEIN BROWN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="344"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="960" mass="106844" checksum="CBB391049292CCBC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A734</accession>
    <name>A0A075A734_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173024.1">
        <property type="nucleotide sequence ID" value="XM_009174760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A734"/>
    <dbReference type="GeneID" id="20323027"/>
    <dbReference type="KEGG" id="ovi:T265_08848"/>
    <dbReference type="CTD" id="20323027"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12052" checksum="8DBDEC86AA2BE9C7" modified="2014-10-01" version="1">MGNNTHVEELQAGEANYTDTSDVHTLIIQLWSATCSGKQPQSTIKIPRTSMGSKSPPCLVKKVNITQSHGKQVVKFGPEGSGGFQAEIMMKNLPDSVSKGSMPSIRKFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A983</accession>
    <name>A0A075A983_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164064.1">
        <property type="nucleotide sequence ID" value="XM_009165800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A983"/>
    <dbReference type="GeneID" id="20327007"/>
    <dbReference type="KEGG" id="ovi:T265_12839"/>
    <dbReference type="CTD" id="20327007"/>
    <dbReference type="OrthoDB" id="6260718at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="20123" checksum="DA73859B8EDE6FD7" modified="2014-10-01" version="1" fragment="single">VEAVFATRRITSQVTRFSYVVQHPLCDVAREFEDLLEDIPKENPYDALRAAVISRTGKSENKVLRDLFTTVELGDRSPSQMLRHMHSPMRPAVNPATKVLTPDLADPYAALIREYKDLFQPSAFPTQLHHEITHKSFTTGNPVSLCPRRLAPDKLATAKRSLSTCSIWALYLFLDITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAB3</accession>
    <name>A0A075AAB3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163630.1">
        <property type="nucleotide sequence ID" value="XM_009165366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAB3"/>
    <dbReference type="STRING" id="6198.A0A075AAB3"/>
    <dbReference type="GeneID" id="20315548"/>
    <dbReference type="KEGG" id="ovi:T265_01360"/>
    <dbReference type="CTD" id="20315548"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="411" mass="45854" checksum="73EB3E54DEA2FF39" modified="2014-10-01" version="1">MSLFEDIQPAPPIEVFAVSEACQRDPEPDKVNLTVGAYRTNEGLPWVLPCVRSVELSMAKDEKFNKEYLPVTGLGTMCVNALKILLGENNPLIAEKKADGCQSLGGTGALYLGMQFLSRVAKYTTLYVSRPTWVYMLLAGNHKMLASLAGLHVQDYRYWDSAKLAVDFDGMLEDIKNAPSNSIILLHACAHNPTGMDLSREQWMQLAIIMKEKALLPMFDIAYQGFASGDLNNDAWAVRYFASLGMELFAAQSFSKNFGLYNERVGNLAFITNDAKYTANIKSQLTILVRKTWSNPPQHGARIVDTILNDPQLCAQWKADVATMANRIKEMRQALYTRLLALKVPGSWEHIVNQIGMFAYTGLSAAQAEHMRTKHHIYLLNDGRINICGLTTKNVEYVANAIYETLMAIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAE9</accession>
    <name>A0A075AAE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171707.1">
        <property type="nucleotide sequence ID" value="XM_009173443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAE9"/>
    <dbReference type="GeneID" id="20321993"/>
    <dbReference type="KEGG" id="ovi:T265_07814"/>
    <dbReference type="CTD" id="20321993"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="77168" checksum="814BF25F0A5F751B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC35</accession>
    <name>A0A075AC35_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171025.1">
        <property type="nucleotide sequence ID" value="XM_009172761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC35"/>
    <dbReference type="GeneID" id="20321462"/>
    <dbReference type="KEGG" id="ovi:T265_07283"/>
    <dbReference type="CTD" id="20321462"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10314" checksum="E126B1C7C8B6D530" modified="2014-10-01" version="1">MERLRSAIQCATNVSTFGNLQKTFINILLLTEQGAKRATSYFPIVIVFPSDRVSHRYRATECAAPGRLMFQSLRYLKHRDTCIFVMYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AES3</accession>
    <name>A0A075AES3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169228.1">
        <property type="nucleotide sequence ID" value="XM_009170964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AES3"/>
    <dbReference type="STRING" id="6198.A0A075AES3"/>
    <dbReference type="GeneID" id="20320025"/>
    <dbReference type="KEGG" id="ovi:T265_05843"/>
    <dbReference type="CTD" id="20320025"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1203" mass="130595" checksum="1466907BF8ED142B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG08</accession>
    <name>A0A075AG08_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_04866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER28264.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_04866"/>
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    <dbReference type="OrthoDB" id="6255742at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="207" mass="23488" checksum="0A2FBA8DECF842A7" modified="2014-10-01" version="1">MPRKFVNIIRSLYSQSSGRVGVYGELPKSFRTQSGVRQGCPLSPFLFNFVIDEIMKRTLEGLQNPGWGPRAPHCVWVETLQDMAAKRYQWRSCCQFLSRLPELSNKSWLYGSEASVLNTDVMLSMMMMRDMLVPLGPKWLEREFTVWKGRGSDPPSASRLPMSRLRQPGSIPAHVPPSCGMAARRRKGATAGWFILFFISEGWILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHH1</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="1" type="ORF">T265_03571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_03571"/>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9273" checksum="C04E5808E1EA2BF1" modified="2014-10-01" version="1">MSYFGIESASDSRVGTIHHDALKDVNSFPINYNSSPFPSVRSSCDRITRLPIYLGSTQTGCQICTDRSSLLVPVMDSAHYVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJC7</accession>
    <name>A0A075AJC7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164753.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20315046"/>
    <dbReference type="KEGG" id="ovi:T265_00858"/>
    <dbReference type="CTD" id="20315046"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15440" checksum="847C88A2BBFC3666" modified="2014-10-01" version="1">MPYNARALEPPVQAETADVKSIRRYHECLRVQSVDLDLAFKRLECSRLELPDSLKNANFAADVGWDKELCEADGLLTCRVHNPTSATYEVSVTNIPVGPRDSRSSAYDKDASPHNEVIIIRRQYHRQKLDLKEQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU37</accession>
    <name>A0A074YU37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605687">
        <property type="protein sequence ID" value="KER18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178025.1">
        <property type="nucleotide sequence ID" value="XM_009179761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU37"/>
    <dbReference type="GeneID" id="20326500"/>
    <dbReference type="KEGG" id="ovi:T265_12332"/>
    <dbReference type="CTD" id="20326500"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12736" checksum="95F400ECA514F87B" modified="2014-10-01" version="1">MGNNRPARSSPNLAIKSMTDGALFSQIYLFLSGSDFHSAFLQIAAETDIVTPKVVASLKAMSSKLRNLLIKIRKEERKKSLSRIHISFKRHCIKQDLASGTHPVCVCWGHERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVR8</accession>
    <name>A0A074YVR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598090">
        <property type="protein sequence ID" value="KER18763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177490.1">
        <property type="nucleotide sequence ID" value="XM_009179226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVR8"/>
    <dbReference type="GeneID" id="20330005"/>
    <dbReference type="KEGG" id="ovi:T265_15840"/>
    <dbReference type="CTD" id="20330005"/>
    <dbReference type="OrthoDB" id="382863at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053347">
        <property type="entry name" value="Axonemal_MT_stabilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404:SF1">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="231" mass="26582" checksum="1DC72BE3FC5CDE1F" modified="2014-10-01" version="1" fragment="single">MPDLLESKNVLIGKSTDDVFRTSFGVGHHWRPGFYFPDSNTLTKLSTEQTCSQRPGGAVKPSDHYTTTTGSFHDPKVLSEELQNTRALPPPHHWNVHYISDFRSRYLAGRHYRPLSPSHQKSETHDEFRQHDSPSEVWRPIGMQPFVLDNHHKEGPSKKIVASTVNRSLRGRTLLPKDKEVLRHLDPYLTTTMKEHRVWTPEELEACAKKDIATYWDLESYPKARGFGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWY8</accession>
    <name>A0A074YWY8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597307">
        <property type="protein sequence ID" value="KER19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177097.1">
        <property type="nucleotide sequence ID" value="XM_009178833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWY8"/>
    <dbReference type="STRING" id="6198.A0A074YWY8"/>
    <dbReference type="GeneID" id="20329805"/>
    <dbReference type="KEGG" id="ovi:T265_15640"/>
    <dbReference type="CTD" id="20329805"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6799" checksum="6C89413FBE673ADC" modified="2014-10-01" version="1" fragment="single">MYICKEILSGGQPSPGDDSTLSTDLDDTGKKLLLKPESQVPHHLRVTSFLQEVACASCTLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXH2</accession>
    <name>A0A074YXH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of specific proteins in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase maturation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597235">
        <property type="protein sequence ID" value="KER19358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176897.1">
        <property type="nucleotide sequence ID" value="XM_009178633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXH2"/>
    <dbReference type="STRING" id="6198.A0A074YXH2"/>
    <dbReference type="GeneID" id="20326014"/>
    <dbReference type="KEGG" id="ovi:T265_11846"/>
    <dbReference type="CTD" id="20326014"/>
    <dbReference type="OrthoDB" id="434126at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF5">
        <property type="entry name" value="LIPASE MATURATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="563" mass="64515" checksum="05FD09C5B474870E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYH9</accession>
    <name>A0A074YYH9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597153">
        <property type="protein sequence ID" value="KER19698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176559.1">
        <property type="nucleotide sequence ID" value="XM_009178295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYH9"/>
    <dbReference type="STRING" id="6198.A0A074YYH9"/>
    <dbReference type="GeneID" id="20325770"/>
    <dbReference type="KEGG" id="ovi:T265_11602"/>
    <dbReference type="CTD" id="20325770"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="124"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="602" mass="68402" checksum="F020672A2C00DC20" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z077</accession>
    <name>A0A074Z077_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597593">
        <property type="protein sequence ID" value="KER18877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177376.1">
        <property type="nucleotide sequence ID" value="XM_009179112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z077"/>
    <dbReference type="GeneID" id="20329940"/>
    <dbReference type="KEGG" id="ovi:T265_15775"/>
    <dbReference type="CTD" id="20329940"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42585" checksum="7C80A395656D8DA8" modified="2014-10-01" version="1" fragment="single">MEFFSPFNVVQALRLEKDTGAALVEEIECSTPNVAYYADHFNYQMFSGTAATANGLKNKSALFARPGLVVRQLVYKLRSINWNSAKQQLFSKQNSVIHCVLRCVVILLFILVLTVLFVDRKNISYDRWLRSHQCQSHRCLKAAGLLREKMNTSVSPCDNFYRYACGLHFRPHQPTTEPDTPTAQGSQAYQLGFKQGSVMHLNKEKAGRLLRVHRPAIDHLTQINIHAIISGLDHIYSTQYTKRGSAKFKVAQWYQSCTHRTMRDWLGTRSFISTVAPAIGGIWILDKNATNETGASGNTNSTVKWPNRMFQRYDISTNIPMKPDWSWMNATKKLQTILHVPVFVDFNVQATPGSQPQVFFVPDGASWMTAGYFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z090</accession>
    <name>A0A074Z090_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175899.1">
        <property type="nucleotide sequence ID" value="XM_009177635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z090"/>
    <dbReference type="GeneID" id="20325248"/>
    <dbReference type="KEGG" id="ovi:T265_11080"/>
    <dbReference type="CTD" id="20325248"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="388" mass="43743" checksum="64F52E1F78412E53" modified="2014-10-01" version="1">MIDEIVSVPVTGFADRFVTELGSIDFCCECTGHDVTVEWSHQELQPAPSFLALDSISKPEDPKLRLHLVPTVGLHQRANLRAPFWRKHDFKETVAFALSFGLWKRPVWIMNSVLPPRHTIGPTQLSQTIRGAGCISPSSECGTDRPDIKAFADYRADRDHPGVYAAFRDLFVTQGRESNPLPKYHTKRHRNSKSKGEEHISQKPRIRVEGTDSVPKRKSLKEFGLHLQLFHTRQLTVIIVVKSAKHIVNFLTVILNDILSEITDGLAKQCKTGLFTIILLIIKLKKQTKPRRKLLNHFTGEYDGCSNTKERGDQSPMRSQIFEEVDVRTFLEDFEEAARAAGLDTARGKLAALETYPQEPEKDGPGCGQKGPSEDGLCRCERSFFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0E3</accession>
    <name>A0A074Z0E3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597049">
        <property type="protein sequence ID" value="KER20511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175747.1">
        <property type="nucleotide sequence ID" value="XM_009177483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0E3"/>
    <dbReference type="STRING" id="6198.A0A074Z0E3"/>
    <dbReference type="GeneID" id="20325127"/>
    <dbReference type="KEGG" id="ovi:T265_10959"/>
    <dbReference type="CTD" id="20325127"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF2">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31311" checksum="C90B098492AB7AB7" modified="2014-10-01" version="1">MLRALSDYGTTLCHQAEPHSKLFGKNMCFEMTKTMTVVNRMRITFCASPSLLTTDVSLLVVKMHTYVYMRKDGAMNVVSCGQTLAYHPRGKEDRRYLPIFISASWDDSIQVWHDQQGSSLWQIYGTYVAGNDGLDIDPTKNIILTCSWRRENSLVQLWPFPNFLIEGEREITERENMSYKRPLSRFVYEPLKQVTRGYVAKFDAHYKLILYAGSNKNLVSILDIENNTVIAEVTHLDNGVYSGAVFRDPETPDQLRIIYTSGKGVSLGKINMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1S2</accession>
    <name>A0A074Z1S2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597207">
        <property type="protein sequence ID" value="KER19442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176811.1">
        <property type="nucleotide sequence ID" value="XM_009178547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1S2"/>
    <dbReference type="GeneID" id="20325955"/>
    <dbReference type="KEGG" id="ovi:T265_11787"/>
    <dbReference type="CTD" id="20325955"/>
    <dbReference type="OrthoDB" id="10290866at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11332" checksum="0EC6471B71B95396" modified="2014-10-01" version="1">MNVTCSMDKAHTDSSGEVFANLHMRLPLDELKSYDVKYEGTALTETISSLVVAYKPKKQFRIGANARAFVFKIGAANNNGICKWLTVFLAFILVNNLLSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z283</accession>
    <name>A0A074Z283_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_10496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="EMBL" id="KL596994">
        <property type="protein sequence ID" value="KER21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175145.1">
        <property type="nucleotide sequence ID" value="XM_009176881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z283"/>
    <dbReference type="STRING" id="6198.A0A074Z283"/>
    <dbReference type="GeneID" id="20324664"/>
    <dbReference type="KEGG" id="ovi:T265_10496"/>
    <dbReference type="CTD" id="20324664"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05060">
        <property type="entry name" value="PTKc_Syk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000216">
        <property type="entry name" value="Tyrosine-protein kinase SYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="201"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="771"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118708" checksum="8C6D45149582AB9A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4M4</accession>
    <name>A0A074Z4M4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597052">
        <property type="protein sequence ID" value="KER20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175772.1">
        <property type="nucleotide sequence ID" value="XM_009177508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4M4"/>
    <dbReference type="GeneID" id="20325147"/>
    <dbReference type="KEGG" id="ovi:T265_10979"/>
    <dbReference type="CTD" id="20325147"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7137" checksum="1C5429FB8923437A" modified="2014-10-01" version="1">METGAGEGVLANCNSPRHKYGRPLAYLFFTVEDIRQFLALDQPVPPLRARPRPSGDEIAPDDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4R8</accession>
    <name>A0A074Z4R8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604022">
        <property type="protein sequence ID" value="KER18300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177953.1">
        <property type="nucleotide sequence ID" value="XM_009179689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4R8"/>
    <dbReference type="STRING" id="6198.A0A074Z4R8"/>
    <dbReference type="GeneID" id="20330316"/>
    <dbReference type="KEGG" id="ovi:T265_16151"/>
    <dbReference type="CTD" id="20330316"/>
    <dbReference type="OrthoDB" id="6258953at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10350" checksum="17218FC01F5C4C4F" modified="2014-10-01" version="1" fragment="single">AGALFPREHPVARRLHAVGLLQPRVEGSQLAVVWLERVHRVMHAHEIQLGNPASLIRIPLHSPFLECLARQSNAGRADKPPTGAKDDVRSTSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4X3</accession>
    <name>A0A074Z4X3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597041">
        <property type="protein sequence ID" value="KER20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175680.1">
        <property type="nucleotide sequence ID" value="XM_009177416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4X3"/>
    <dbReference type="GeneID" id="20325071"/>
    <dbReference type="KEGG" id="ovi:T265_10903"/>
    <dbReference type="CTD" id="20325071"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="18377" checksum="B06860F8F357EA86" modified="2014-10-01" version="1">MDLEMQQNCHDVADQVELKPKTFTVASLPWAVGRMATESGADRGPTMELLHMEQRIISARRGRGHIQDHLQQISHQYSHCQTDQPTSDNDLPNHHKTYTMQANEQQPQVGGFLKHQHHVEWMDVSRDGNVPKDDIVRIWAIQSNIFFYLGASTHEDSSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5V5</accession>
    <name>A0A074Z5V5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FERM C-terminal PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597010">
        <property type="protein sequence ID" value="KER20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175346.1">
        <property type="nucleotide sequence ID" value="XM_009177082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5V5"/>
    <dbReference type="STRING" id="6198.A0A074Z5V5"/>
    <dbReference type="GeneID" id="20329385"/>
    <dbReference type="KEGG" id="ovi:T265_15220"/>
    <dbReference type="CTD" id="20329385"/>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42580" checksum="0CE9AF6C9944360B" modified="2014-10-01" version="1">MVCDGKDFLVFLKHNENKTHHLTFECESKAAALAIWHWTMDRKCFFTLKQAGEAKRVRPSSSIFRRSHTYRFSGRSHQELSSIPIKNSSTEFIRVSSLRRDGGYGNASLGHATLPTRIRPPLDLREYRYNELVEVPADHNPVSETLRAVLIPDTVTESPTEEDVPTLTIINNQEIEPALESACFSQPVEEPPIEAKQVPQQASMPDPKIQRNHDSCDESSLGIRNRIDSKLVQSVVYQQVVSEFDHTVDTHLDRFAPSGDPKLTPSSNGVSSNNGSASMIRNGPVSKKGTVFSDGLVDNTKEPRCTLTETGKCFDSGRAVKATTVTVVAMMVFAGLIILMETNPSSESTVIYAMRNNAMISSFDAYIYTPVRNVISAGLSLLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5W4</accession>
    <name>A0A074Z5W4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173773.1">
        <property type="nucleotide sequence ID" value="XM_009175509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20323611"/>
    <dbReference type="KEGG" id="ovi:T265_09442"/>
    <dbReference type="CTD" id="20323611"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="16120" checksum="CB91236CAAD0B1CB" modified="2014-10-01" version="1">MPHEGGTRARILPGCPSLDRGGRVAEAGFEPRTFRSRLLIRWLLICSPSLTIGLQTXYEETSSVCIWVGTSSLPVCVYIALEGYPLSSDVYSLNHPLMESSLKLPPQEAHYGTDCPSVEKATHFPSVYEATPSFIGCQSKRMTSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5Z9</accession>
    <name>A0A074Z5Z9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596891">
        <property type="protein sequence ID" value="KER22571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173675.1">
        <property type="nucleotide sequence ID" value="XM_009175411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5Z9"/>
    <dbReference type="STRING" id="6198.A0A074Z5Z9"/>
    <dbReference type="GeneID" id="20328986"/>
    <dbReference type="KEGG" id="ovi:T265_14820"/>
    <dbReference type="CTD" id="20328986"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="507" mass="57003" checksum="A76CC75A669CF55D" modified="2014-10-01" version="1" fragment="single">MMLTGEWKEQIKQLLGDRDRLQKTQFEYVITDYSKLRDRVGQLTKEYNRVSLELKSSRQENLDLSLKLEKSNAFMSHDFEQKVFRLQEEVTELHRQKGDLASNVIDLSKSVQEKDKLLSSVHSKLSELENEARNLQQANMGYLNEIHNLERANKLLRDEKNAMSETLQAVQVKCAELEEDKCRLIERINKLQSVVERLKNLEHDVNYRKAQETIRKQLAEAASLSVDEPHNMGPLVAAVVPTKAVAEVLANEGEVNSVRFTPSGNLFGSAGFDRKLRLWSVVGGKCELRSTLVGCNASISAIDFDPKETVVLGASSDFSCRVWTLADSRLRVNLTGHAKSVVSAKFIGSAKRVVTISADRTIKLWDVDRCHCQRTIMSASASQDVVACTAFGAVITGHYDHNLRIWDERSGTNTDTIALSSRVTGLDISSGDKTTEKRRKESIIDLNKYLDKKIRVKFSGGREATGILKGCDNLQNMVLDCTTEFLRDPDDPHRLSDDTRELGLVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z716</accession>
    <name>A0A074Z716_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597377">
        <property type="protein sequence ID" value="KER19020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177230.1">
        <property type="nucleotide sequence ID" value="XM_009178966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z716"/>
    <dbReference type="GeneID" id="20326218"/>
    <dbReference type="KEGG" id="ovi:T265_12050"/>
    <dbReference type="CTD" id="20326218"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9486" checksum="F235A608595946C8" modified="2014-10-01" version="1">MPLCMERYTYLGSCITSEGSVTDNVNARAPKAGITVTDLHRLRYQKGRSVGLNRRVVCCYTAAMLGHSRGFAEKYIVRLAAGVQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7R4</accession>
    <name>A0A074Z7R4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173113.1">
        <property type="nucleotide sequence ID" value="XM_009174849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7R4"/>
    <dbReference type="STRING" id="6198.A0A074Z7R4"/>
    <dbReference type="GeneID" id="20328865"/>
    <dbReference type="KEGG" id="ovi:T265_14699"/>
    <dbReference type="CTD" id="20328865"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37248" checksum="BEB2B24D9D098F40" modified="2014-10-01" version="1" fragment="single">MIPYLRRRILAGDDAGPGLGDKMYAALKCHRVEMLCQRLRRDRKAKKTLDKEENGSQRKPTEISIVVEEASPDLNSSRNGRNGKTGVDDRHESVTSVSGRQNSFRLVPTKFEVTSTKPAEPPAEPVHYLAVRAYPTEHDLSVTRRGMLTQPVLPPIGEEEPQELEIISDRPHEYKVFSQLQILTAVFDSFAHGGNDVSNAIGPVMGLWIVGVTQEVNSKMANPYWILIYGGVGIAIGLWVWGRRVIKTLGEDLTIITPSSGVCIELGSAMTVLFASKLGLPISTTHCQVGSVVAVGRFRSRDNVDWRIFRNVIIAWVVTVPAACGISALLMYLLSFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7S4</accession>
    <name>A0A074Z7S4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597260">
        <property type="protein sequence ID" value="KER19280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176977.1">
        <property type="nucleotide sequence ID" value="XM_009178713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7S4"/>
    <dbReference type="STRING" id="6198.A0A074Z7S4"/>
    <dbReference type="GeneID" id="20326064"/>
    <dbReference type="KEGG" id="ovi:T265_11896"/>
    <dbReference type="CTD" id="20326064"/>
    <dbReference type="OrthoDB" id="428850at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="343" mass="37816" checksum="711E457EA19384AE" modified="2014-10-01" version="1">MIRKNRSAVTPFRCLAAMLAEGSTRARSPKPRQGKLRGRGRVRTKDLPFEPVISKQPVDSKSSDGLSTNLKPKSFSCNTLSVSGRHVTRNKHEGSHTSRLPEARQEKSRCRGRVRITYLPFEPVISKQPVDSKSSDGLSTNLKPKSFSCNTLSVSGRHVTRNKHEGSHTSRLPEARQKSRCRGRVRITYLPVMIWSLGTVETADGLPPPTSKLTNTRKRSFQEGEVAQRLECKFTDWKVRGSNPTSASRLPLFRLGQPGSIPALVRPSGGMAARHRKGATAGRGTVTRHHSGSQTLRTDNKNIACSPSLSHLVNGGDQVGRPISQFPVCPFIPSQFVANPRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z812</accession>
    <name>A0A074Z812_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_08757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="KL596853">
        <property type="protein sequence ID" value="KER23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172910.1">
        <property type="nucleotide sequence ID" value="XM_009174646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z812"/>
    <dbReference type="STRING" id="6198.A0A074Z812"/>
    <dbReference type="GeneID" id="20322936"/>
    <dbReference type="KEGG" id="ovi:T265_08757"/>
    <dbReference type="CTD" id="20322936"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="238"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="635" mass="71169" checksum="9E3ABF01C7AA613E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z822</accession>
    <name>A0A074Z822_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596858">
        <property type="protein sequence ID" value="KER23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172996.1">
        <property type="nucleotide sequence ID" value="XM_009174732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z822"/>
    <dbReference type="STRING" id="6198.A0A074Z822"/>
    <dbReference type="GeneID" id="20322999"/>
    <dbReference type="KEGG" id="ovi:T265_08820"/>
    <dbReference type="CTD" id="20322999"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="650" mass="71880" checksum="DA3E963BDB2BF7B0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9A5</accession>
    <name>A0A074Z9A5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172434.1">
        <property type="nucleotide sequence ID" value="XM_009174170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9A5"/>
    <dbReference type="GeneID" id="20328721"/>
    <dbReference type="KEGG" id="ovi:T265_14555"/>
    <dbReference type="CTD" id="20328721"/>
    <dbReference type="OrthoDB" id="6252240at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="343" mass="38149" checksum="44F0E7B84CF09B60" modified="2014-10-01" version="1">MSKKDVRISASSVSLRDDSRSQSESISYFVSSAKRVGKSTVSKKHTFSANEAEKLMKKHLKKKSIPVNIHCVEDGLHFAATTPKHRKKVKELVTYRDIQHIFIYSLNPQLFMLCVEESAKKGKKFYESFQCDNANDIGRICELTTEAKDAPDGKLHIRTTAAEIDYQNQPDTSREQNHVTTPQTGEERISWQQRGSSTVQVQESPKVSKEAVSLSPLELSSGPTYEAVAPVQSGMTFSAYKPSADPGLDGTENNDGLVELTSSRITIRSVSRAAGEKISRPRCLEDHNVEELNYMFGEPLTYMIEEPGGSKISARGPIYLYAKRVLNSNHPVCSTNSASKLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9D0</accession>
    <name>A0A074Z9D0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174103.1">
        <property type="nucleotide sequence ID" value="XM_009175839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9D0"/>
    <dbReference type="GeneID" id="20323852"/>
    <dbReference type="KEGG" id="ovi:T265_09684"/>
    <dbReference type="CTD" id="20323852"/>
    <dbReference type="OrthoDB" id="6276798at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="448" mass="48705" checksum="19EDCF0C612EDA0B" modified="2014-10-01" version="1">MRDRNEESTSGTIGVSEVDGPRYAAENSIIIPKALNRSRSPLLLDDALSSTPVEVNSSDFGGVNAVSWISDAAASDGSHVMYREMDPYNYASVANSLIPSPTLSSADSGEPTREGSWVAVTRLANSKNHTVTTTMFKSGSDQPDSNQLLSQKTGTTVSHCDEEVDGLELARLARNLWPNRKSGRRSTGVVVLPDVKPNRSSNLAPSLESNAKRPSSAAMRPQDLNIRPAVRQPGQLFKMEDPLQPNVWRSDTESPMELDWDHEPGTVSPQRKKINPTRPVPAVVSNTNGRNGRRAEEDGFTEVSLFPVRPRRHPRAAVNLPIQPTEVESGRDDGSAKIPVRSKRWSCSDKLLSTTSIHRMHPTVPAQTAIPCSNLFTSPTDDETLTGPNPPSDDLFDSGFAGLSQSFADADSDGCGIGSAGGGRLTDFLWEHEMFEDTGFPSRNRLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9L7</accession>
    <name>A0A074Z9L7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597116">
        <property type="protein sequence ID" value="KER19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176317.1">
        <property type="nucleotide sequence ID" value="XM_009178053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9L7"/>
    <dbReference type="STRING" id="6198.A0A074Z9L7"/>
    <dbReference type="GeneID" id="20325576"/>
    <dbReference type="KEGG" id="ovi:T265_11408"/>
    <dbReference type="CTD" id="20325576"/>
    <dbReference type="OrthoDB" id="6273183at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="8840" checksum="5ED2ED817470971D" modified="2014-10-01" version="1">MSGRGKGDKTRVKAKTRSSRAGLQFPVGRVHRLLRKGNYAEHVGAGAPVYLAAVLEYLAAEVLDLAGNAARDNNWTCCTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAS8</accession>
    <name>A0A074ZAS8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crossover junction endonuclease EME1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171848.1">
        <property type="nucleotide sequence ID" value="XM_009173584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAS8"/>
    <dbReference type="STRING" id="6198.A0A074ZAS8"/>
    <dbReference type="GeneID" id="20322103"/>
    <dbReference type="KEGG" id="ovi:T265_07924"/>
    <dbReference type="CTD" id="20322103"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40106" checksum="A861996A9F9E2064" modified="2014-10-01" version="1">MKIPWPQPFEDGDVRTFPEDFEEFAEAAGLETDRGGYEAVQDGQDGTRIGPDRVLLSSCWIALCPTLDGVSRHQLLSDQFVEGVQPALGVQLRLARATGQLSVEELMHPARELPQEPLATLQSPKNRDGSSVEELQTMVDQLTEQLAAVKTESKRTSGVGASTSLSINELCSDLQIRWGVRATRICSTVHDVALVLASYHRSIGERPFKEGRLSRDEGLTFLPDTVRKGLAGCASRGRGAGPAPNISGDDPDGTDSLAVHSWANRLWLAQLGQWRGLTGEVAHAIAQVYPTAFSFFQACQKDLETVDATNSDGSQISGKRRHPLEANLAELEIRRGAGILSSRRRLGPEFARRLVTHFTSEDPSEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBL1</accession>
    <name>A0A074ZBL1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171718.1">
        <property type="nucleotide sequence ID" value="XM_009173454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBL1"/>
    <dbReference type="STRING" id="6198.A0A074ZBL1"/>
    <dbReference type="GeneID" id="20328563"/>
    <dbReference type="KEGG" id="ovi:T265_14397"/>
    <dbReference type="CTD" id="20328563"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070778">
        <property type="term" value="P:L-aspartate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="38597" checksum="2C2DCD5C842AE77A" modified="2014-10-01" version="1">MLPDNIVKSMTHQVATRIVSTTVIRNTSNLNQTDMQPETVEKAVLVSVDSTNVLGLIVFSIAFGLCIGQIGERGKVVVEFFRAVEEVVMKLIYIIMWYAPLGIFFLVMGKILELPDLLGAIRGLGLFMATVTAGLIIHLFIILTLIYLAMTRKNPYTLFGAMLPAFFTALGTASSSATLPITFRCLEERLQIDTRVTRFVLPIGATMNMDGTALYEAVASIFIAQVNDFNLDIGQLVTISVTATLAAIGAASVPGAGLVTMVLVLTSVGLPVNDISLVLAVDWLLDRFRTAVNVMGDSFGAGIVAHLCRKELAENPATSKSSVNAATAFEGVIYRLNSDMELKRYENADETETRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBM0</accession>
    <name>A0A074ZBM0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171705.1">
        <property type="nucleotide sequence ID" value="XM_009173441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBM0"/>
    <dbReference type="GeneID" id="20321991"/>
    <dbReference type="KEGG" id="ovi:T265_07812"/>
    <dbReference type="CTD" id="20321991"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="25432" checksum="091D4202EA6AE811" modified="2014-10-01" version="1">MVTLNALLLDRKRTTVECFLRSILRDDPSGKSAKLLTGRSVVRIPPLPLDFPCLGLGSLEVSQPSCFLRATECGAPGRPMFQLVRYSRYRDTATFSSLQFKAGWCTNECILRIPYNFVSTRLTDGLMSLKKGEADHGLSSSHKRIKTHRFRKCLVTIGRFILGNKSTDCRQTFPNTMGFDPQRGRDEPSLGDLTVSQSLCLLRVAWQLGTGSMLHLNDFLCWASFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC62</accession>
    <name>A0A074ZC62_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171334.1">
        <property type="nucleotide sequence ID" value="XM_009173070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC62"/>
    <dbReference type="GeneID" id="20321704"/>
    <dbReference type="KEGG" id="ovi:T265_07525"/>
    <dbReference type="CTD" id="20321704"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30218" checksum="09CCEE4FCDD0BA14" modified="2014-10-01" version="1">MSPSNAEMQYRKNSETGKVFVVGVDKTGTSFVKTLLQTLYLQPCLHSSDLSAARTGILSEWTALAEESDKLARQKKLGRLLENYRFAAGFPAVAYFDDLLEMYPSAKFILTIREAEPWLATIRSTSLPRAYKNSDRRLIDSTLYVVGFNRLEQLNRRMFKRLFGPNVDLQDDNQVIQAYIRWNDYVRSVVPKDQLLVYKVKDRWEPLCKFLGVPVPDKPFPNTRRSMTLTRIPKSQIDRLQHFIICLAVYIMIGISVIRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCJ9</accession>
    <name>A0A074ZCJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atg6 BARA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171227.1">
        <property type="nucleotide sequence ID" value="XM_009172963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCJ9"/>
    <dbReference type="STRING" id="6198.A0A074ZCJ9"/>
    <dbReference type="GeneID" id="20328452"/>
    <dbReference type="KEGG" id="ovi:T265_14286"/>
    <dbReference type="CTD" id="20328452"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6 BARA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11394" checksum="B34A98ED930DF460" modified="2014-10-01" version="1" fragment="single">MCIFLKCLHQVEKVVETMTQSRMPYLIQDGGKIHDPEERRTYSIKWSGNSEENWTKALKGMLLNMKWIIARLVALDGQRRISQLGTDARNASTPTASGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCM4</accession>
    <name>A0A074ZCM4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PWWP domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172890.1">
        <property type="nucleotide sequence ID" value="XM_009174626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCM4"/>
    <dbReference type="GeneID" id="20322920"/>
    <dbReference type="KEGG" id="ovi:T265_08741"/>
    <dbReference type="CTD" id="20322920"/>
    <dbReference type="OrthoDB" id="5964980at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042778">
        <property type="entry name" value="ZCWPW1/ZCWPW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15999:SF2">
        <property type="entry name" value="ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="6">
        <location>
            <begin position="311"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="85979" checksum="AE83974ED3B24E2A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCR8</accession>
    <name>A0A074ZCR8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172833.1">
        <property type="nucleotide sequence ID" value="XM_009174569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCR8"/>
    <dbReference type="GeneID" id="20322874"/>
    <dbReference type="KEGG" id="ovi:T265_08695"/>
    <dbReference type="CTD" id="20322874"/>
    <dbReference type="OrthoDB" id="425681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="242" mass="27644" checksum="27DAF776EC59E0C9" modified="2014-10-01" version="1">MKQTRITFAKLHPLWRQKGISPDLEGRVYQAAVWAVLHDCLTWPLRTDELSSGFGPLMSQKRYWCWMASRLKHEVAWCSIFNCLRTSQTRDSAGSHATKCAAPARPMFQSLRYSRYHDTCIYLLPGHITYERFSWVPSRKIELNDGSREKIRNSGTVFRISVAIIVDDLCREQTNSSCRGRCRFDTATKKLSSGFQACATLPDWRVNRSSQPGQLLGRPSISRAHQSHRSSVNTFACLDALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDS3</accession>
    <name>A0A074ZDS3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_08402</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596835">
        <property type="protein sequence ID" value="KER23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172462.1">
        <property type="nucleotide sequence ID" value="XM_009174198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDS3"/>
    <dbReference type="STRING" id="6198.A0A074ZDS3"/>
    <dbReference type="GeneID" id="20322581"/>
    <dbReference type="KEGG" id="ovi:T265_08402"/>
    <dbReference type="CTD" id="20322581"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="16"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="859"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="609"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="933" mass="103566" checksum="4A0235F3D2FFC1ED" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE23</accession>
    <name>A0A074ZE23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170741.1">
        <property type="nucleotide sequence ID" value="XM_009172477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE23"/>
    <dbReference type="STRING" id="6198.A0A074ZE23"/>
    <dbReference type="GeneID" id="20328360"/>
    <dbReference type="KEGG" id="ovi:T265_14194"/>
    <dbReference type="CTD" id="20328360"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="651"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="714"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="966" mass="107938" checksum="A4813DBBE7F5432A" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGA2</accession>
    <name>A0A074ZGA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170061.1">
        <property type="nucleotide sequence ID" value="XM_009171797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGA2"/>
    <dbReference type="STRING" id="6198.A0A074ZGA2"/>
    <dbReference type="GeneID" id="20328215"/>
    <dbReference type="KEGG" id="ovi:T265_14049"/>
    <dbReference type="CTD" id="20328215"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="257" mass="28119" checksum="79D645A4B2A025DA" modified="2014-10-01" version="1" fragment="single">RTFVNPSAVSPHLSCPICQEVFVNPQRAPCGHSFCKTCIDPWLTNNPICPLDRRPVTKSSMHHDFLIENVIGDYMVACPWRALGCDFIGPLHLLPSHKKSCLMNPGSLPPALRAHTTELMTRSQVTNTKAACLHEFKKSPSLPVLLSSVQTTATTTPNSASVNTDIENALRVNGASTSSSSPSPSTSQPAEPAETTETSVIHVTDDEEEHLPPVRPPNLLFRLYHNSDTNSRDLLCSFLDNAAIPAPSPPSKRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH81</accession>
    <name>A0A074ZH81_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_09376</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596891">
        <property type="protein sequence ID" value="KER22580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173684.1">
        <property type="nucleotide sequence ID" value="XM_009175420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH81"/>
    <dbReference type="STRING" id="6198.A0A074ZH81"/>
    <dbReference type="GeneID" id="20323545"/>
    <dbReference type="KEGG" id="ovi:T265_09376"/>
    <dbReference type="CTD" id="20323545"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000002">
        <property type="entry name" value="ATP sulfurylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="APS kinase" evidence="16">
        <location>
            <begin position="182"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="18">
        <location>
            <begin position="364"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="17">
        <location>
            <begin position="526"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER22580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="762" mass="86176" checksum="188C3CA807983373" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHR7</accession>
    <name>A0A074ZHR7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VHS domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173449.1">
        <property type="nucleotide sequence ID" value="XM_009175185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHR7"/>
    <dbReference type="STRING" id="6198.A0A074ZHR7"/>
    <dbReference type="GeneID" id="20323353"/>
    <dbReference type="KEGG" id="ovi:T265_09174"/>
    <dbReference type="CTD" id="20323353"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="4">
        <location>
            <begin position="240"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55806" checksum="269947550AE7E903" modified="2014-10-01" version="1">MHNLFNPHPFSTPVGILTERATDSGQSTEDWSLILEICDTINETDEGPKEAIRAIRKRLSSSAGRDHTSVWYTLLLLDACIQNCGRRFHSQVANKEFLHDFLKLLSPKNEPSQQLQNQVLYMLKSWVELNWDVPGKRDMEKIYTTLRQKGIQFPQSPANEIFLNSVLSSQGVSSSNLPNQFYAVPIASQAAVNRTGMGEVFINTHPGTVRIIQQTDHRFVPTMDAMELDADGTVRHLTSTQRVKLTQDLSVVETNVNVLNDMLAELRPDSVSQDDLVLLQELVQTCRSMHRRVIEFLSQVSDDEVTPSLLQVSDNLNSAFLRYDRFERYRQRAIQLRAGGMRSSSLAALPAAHTRRQQPAAITGGQLLAIADSDPCASTPNGLQLSIPAVNGQVRRNNINDDDDDLLIDVSEGLGGAETTQPVIDCDEVAQWLAVRQLVPVSGESGESSRSGPAMLALQQGIHAMSLSPTTRTIQASVFLALFLEYSLNPILVVDHLWLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIK3</accession>
    <name>A0A074ZIK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170656.1">
        <property type="nucleotide sequence ID" value="XM_009172392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIK3"/>
    <dbReference type="GeneID" id="20328350"/>
    <dbReference type="KEGG" id="ovi:T265_14184"/>
    <dbReference type="CTD" id="20328350"/>
    <dbReference type="OrthoDB" id="6285703at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="18434" checksum="45A139036B29D6A2" modified="2014-10-01" version="1" fragment="single">MLHPNQLRELQMSPNLPRRASAHVIFPLPMDDSSTQIPASRRPSAEKSRLTGTSFLGIKLPSVSNLRRHSYGADRPTNTGAGELPQVEIAPSPPTESRRGSAASFSSRVGCTPKTDNTDSFLNSENTLLTARVCEGPFISAPSSRSSSQRRSGSFIPDQFPNIGGQSSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIX8</accession>
    <name>A0A074ZIX8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172945.1">
        <property type="nucleotide sequence ID" value="XM_009174681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIX8"/>
    <dbReference type="GeneID" id="20322960"/>
    <dbReference type="KEGG" id="ovi:T265_08781"/>
    <dbReference type="CTD" id="20322960"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="35109" checksum="14538470F287AE17" modified="2014-10-01" version="1">MQPSWTQLHCKHIINNNVVANITDSTQDVRHMCSQNTGLTISRENTRPYLSQCADLTPCQLHYRNPTKMYRGNRCADEQSGITGDFCSPIDNRNSGCPMRTDLFQEACLLHQAKQFNLFDTEEPSSTTRLHAVEQHSKISTRMYRWLAMFFACLVVLLVLTYRIIQWYHQYEAMKHYFVYTNQMVNADREDLPNVPLNTNLSAMLPYISEMVERKQGPTATHRRTAGLVVTICNVNPLRGTALFAFQNGPSIYDLLLRRRQSQFGNPEVEGSNTTSRRTLLSVDLISRSGHRMEEMLKRLASMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ75</accession>
    <name>A0A074ZJ75_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170425.1">
        <property type="nucleotide sequence ID" value="XM_009172161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ75"/>
    <dbReference type="STRING" id="6198.A0A074ZJ75"/>
    <dbReference type="GeneID" id="20320975"/>
    <dbReference type="KEGG" id="ovi:T265_06796"/>
    <dbReference type="CTD" id="20320975"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="79"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="444" mass="50882" checksum="066E6B6A1CA5C515" modified="2014-10-01" version="1">MRILALASILPRAENIKSSATPSFHLCLSGERQPLTDKNKTDPGNLGKSLDPVYQSGLNSSQLEKEIADDRTLINERYFGLVNFGNTCYCNSVLQALFFCKPFREKVLQYRLTKSHKKETLLSCLADLFHAITTQKKSVGQIAPKKFISRLKRENGAFDNYLQQDAHEFLIYILNEISDILQAEQQADQQLRKAERSDNDKNPDSVSADRSQNWIQDIFQGCLTNETRCLTCENVRTKDEDFLDLSVDIAQNCSIVYCLKFFSDTEMMQSENKYYCEFCRCKQEAQKCMRVKKPPLILALHLKRFKYSEEVNSFTKLSCRVVFPTELRLPNTSGGAADQNWLYKLIAVVVHSGSGPNRGHYVTLVKSHGLWLLFDDEVVDAKVEFGLQKVYSTVQLRRDIQFGEISSRSASIVRRNLPVFLELRRLVGRTGRCLSERTAWHVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJM3</accession>
    <name>A0A074ZJM3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168723.1">
        <property type="nucleotide sequence ID" value="XM_009170459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJM3"/>
    <dbReference type="STRING" id="6198.A0A074ZJM3"/>
    <dbReference type="GeneID" id="20327941"/>
    <dbReference type="KEGG" id="ovi:T265_13774"/>
    <dbReference type="CTD" id="20327941"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="309" mass="35962" checksum="EE1951BD75DD3637" modified="2014-10-01" version="1">MLANYVFFSESRLFSALLVFRLLNALLIQTTFVPDEFWQSIEVAHKWSFGYGTLTWEWWPETALRSPLHPLIFSVLYNLGSVFGLDSRTFVVLVPRLFHAVLAAAADLHLYRFAVIVSGLETAKGSVRLIRLRSNLIAVTHIPVALYTCLIHQRGPIDTVSALRKAIQRRFPTNREILSENVSILALMPCHTLPPVSFIHLNVSFKQLNCDPDLSLWFDGQRRVHYDEADEFYDNPARWLNERFDGLKRTSSRKPTFITLFDHLFDAHPSLKNLLLHVWGYRECGRFFHAHFLTHRRYGRYIYILCHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK60</accession>
    <name>A0A074ZK60_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_05325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168572.1">
        <property type="nucleotide sequence ID" value="XM_009170308.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZK60"/>
    <dbReference type="GeneID" id="20319507"/>
    <dbReference type="KEGG" id="ovi:T265_05325"/>
    <dbReference type="CTD" id="20319507"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="939"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1565" mass="174796" checksum="52A445B3B02CBC69" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKH2</accession>
    <name>A0A074ZKH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168702.1">
        <property type="nucleotide sequence ID" value="XM_009170438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKH2"/>
    <dbReference type="GeneID" id="20319613"/>
    <dbReference type="KEGG" id="ovi:T265_05431"/>
    <dbReference type="CTD" id="20319613"/>
    <dbReference type="OrthoDB" id="6287960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30547" checksum="FD32B67D881BB7C1" modified="2014-10-01" version="1">MNGLPWQLNHSSPSVIQHAAAAQQVYAERRKFMRQAPTNTQISIVLSSHPDDADMQLQIRLLIKSAQCGSSRYLEQCPEFIEMPVVSTNICVDRLRVCYLCLKPNHQAKMCRSRHACGLQLCVGNHHLLVHRLSSSKPENEPEPPGIASEGAHHGVSKSNISLAVVPVRILGPKETSRSTPFLDNSASTTLIPSSFLPKLGLKRILVSLINKTITWKCVNYLRRKECISTSFPGYYHVSYDSPDDGNSIFGDRELQLSSTEQQVEKSIAGVNSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKN1</accession>
    <name>A0A074ZKN1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168364.1">
        <property type="nucleotide sequence ID" value="XM_009170100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKN1"/>
    <dbReference type="GeneID" id="20319350"/>
    <dbReference type="KEGG" id="ovi:T265_05168"/>
    <dbReference type="CTD" id="20319350"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7283" checksum="CCA2494E19E1047F" modified="2014-10-01" version="1">MTPPIKDDHMAGGINKKLRARDAGDSCVNNCKLRAPILDASSVTTTVHQSEQLVHTTKKLIARVDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL15</accession>
    <name>A0A074ZL15_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169753.1">
        <property type="nucleotide sequence ID" value="XM_009171489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL15"/>
    <dbReference type="GeneID" id="20320451"/>
    <dbReference type="KEGG" id="ovi:T265_06269"/>
    <dbReference type="CTD" id="20320451"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11083" checksum="36B38C7212317BE3" modified="2014-10-01" version="1">MTVTLESTLLVVAMSSLQSNECTRHDRSEIRDEAGTGRYGRDRDETSVEVIQSEPRQKGSETNQILLVCHLQKQNENTHSCSMSRGKSMNQKEGNKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLS0</accession>
    <name>A0A074ZLS0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_04838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167948.1">
        <property type="nucleotide sequence ID" value="XM_009169684.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLS0"/>
    <dbReference type="GeneID" id="20319020"/>
    <dbReference type="KEGG" id="ovi:T265_04838"/>
    <dbReference type="CTD" id="20319020"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
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                <person name="Nagarajan N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the syntaxin family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPR4"/>
    <dbReference type="STRING" id="6198.A0A074ZPR4"/>
    <dbReference type="GeneID" id="20318167"/>
    <dbReference type="KEGG" id="ovi:T265_03981"/>
    <dbReference type="CTD" id="20318167"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21443">
        <property type="entry name" value="SNARE_NTD_STX6_STX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER29413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="253" mass="28732" checksum="CC51E391535AAD46" modified="2014-10-01" version="1">MSTDYTDPYYTVQDEVIKNLESARTLYQDWLNAGLPKNLQELSDNLRQLLRSIEWDLEDIQETVSIVEGNPSRFQLSEKDVAARRQFLRETRDIVNSVKSQLQDAGKREANGSSISFKVTIARPLTNGSGPNRDPVSQPLRTTDTRPIAFPVPSDPLTEQKHLLRQQDERIDQIGASISTLKGMSRRIGDELEDQVALLDDFSNEMTHTETKLDAVTKRTARLLHLSTSRRQWWAIGCLSVTLFVILILLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ80</accession>
    <name>A0A074ZQ80_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166995.1">
        <property type="nucleotide sequence ID" value="XM_009168731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ80"/>
    <dbReference type="STRING" id="6198.A0A074ZQ80"/>
    <dbReference type="GeneID" id="20318271"/>
    <dbReference type="KEGG" id="ovi:T265_04085"/>
    <dbReference type="CTD" id="20318271"/>
    <dbReference type="OrthoDB" id="6261352at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="44870" checksum="4C6C699797DBAD92" modified="2014-10-01" version="1">MTWQRSMEAITSKLSCACHCRLPGWGPRDGPHQELETLPDKPCRALMVLLHPSYCSHCVASFLIPPLDSPMTVLDLRTNLSARLQCAVIYPPPQIIGERNGVSYNHCTTSARFLRSTVMGDQDLHSIRPYALSPPAVLQEASRTALRSVRPISPVDVFAMPINRSIDGGHHLTTSITYDSDAAQENFVDHFDKLKISASSPAQAHSRQPNDRQPTRRQIRRVNYETGIGTTEVVCQNGFVSLEESPPTLAGGKKLNLLSYDFDWCDLNTPKQKFHNFREQTVWFVLYENAVASCEIQPILFLRQHGAPLDCKGEFGETLLHVAVKTGCLEILRYLITAGLDVTGTDHGPWLISCERGLNQTHCKEFCAIVTLCFQGVQFRHSNTVNTPESEAYKVAEYEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQQ1</accession>
    <name>A0A074ZQQ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166807.1">
        <property type="nucleotide sequence ID" value="XM_009168543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQQ1"/>
    <dbReference type="STRING" id="6198.A0A074ZQQ1"/>
    <dbReference type="GeneID" id="20318129"/>
    <dbReference type="KEGG" id="ovi:T265_03943"/>
    <dbReference type="CTD" id="20318129"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="559"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="888" mass="100087" checksum="17DCA570D05D2E48" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH8</accession>
    <name>A0A074ZRH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166588.1">
        <property type="nucleotide sequence ID" value="XM_009168324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH8"/>
    <dbReference type="GeneID" id="20317958"/>
    <dbReference type="KEGG" id="ovi:T265_03771"/>
    <dbReference type="CTD" id="20317958"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="115" mass="12840" checksum="F74816FF23B2C11B" modified="2014-10-01" version="1">MDARLVKTITSKTGETKIRNTAPEIGQNHIVECGLGKKYGEVEVRNVDSLAMDQLETTMLHKTQVVRTSTEEESTRSIALSSTSYGLVRTGDPSLSRRPSWTRQADMSWPNRTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRM4</accession>
    <name>A0A074ZRM4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167773.1">
        <property type="nucleotide sequence ID" value="XM_009169509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRM4"/>
    <dbReference type="GeneID" id="20318887"/>
    <dbReference type="KEGG" id="ovi:T265_04705"/>
    <dbReference type="CTD" id="20318887"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7499" checksum="82592F956D687FF0" modified="2014-10-01" version="1">MCGSFCDLAISTKAYSSRLGEWSSVQPRTNVTKTCYSGTSLSCTARYHNLGRSEPPYVCVLFIVVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRV0</accession>
    <name>A0A074ZRV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166130.1">
        <property type="nucleotide sequence ID" value="XM_009167866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRV0"/>
    <dbReference type="STRING" id="6198.A0A074ZRV0"/>
    <dbReference type="GeneID" id="20317584"/>
    <dbReference type="KEGG" id="ovi:T265_03397"/>
    <dbReference type="CTD" id="20317584"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="211" mass="25002" checksum="7BFC4DC129C3351D" modified="2014-10-01" version="1">MPKRIRRLLEKRSHLFFKKLTTVNTEDELAFRKMRNRCKSEIRQWNIRKQATILDLARINKNVLFKYMRHRRRNKPSAFSSRDRNGEPSSDPTVKSAQKAFAILRMIRRTFSRITRMDFQILYGAYVKPLLDYANQVVYSGRTKDVTLIERVQRAATRMVAGLKSVDYETRLAMLDLFPLEYRLLRGDLILTYALFEQSLANRFFTVDPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRW9</accession>
    <name>A0A074ZRW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL614190">
        <property type="protein sequence ID" value="KER18054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178199.1">
        <property type="nucleotide sequence ID" value="XM_009179935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRW9"/>
    <dbReference type="STRING" id="6198.A0A074ZRW9"/>
    <dbReference type="GeneID" id="20330492"/>
    <dbReference type="KEGG" id="ovi:T265_16327"/>
    <dbReference type="CTD" id="20330492"/>
    <dbReference type="OrthoDB" id="5811799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7161" checksum="DAC4F2AA67C6B87A" modified="2014-10-01" version="1" fragment="single">FPPGVVNIIPGYGETAGAALSQHPDVRVISFTGSTEVGQLIMTAAATNIKHVKLELGDKSPLIIFADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRZ6</accession>
    <name>A0A074ZRZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166375.1">
        <property type="nucleotide sequence ID" value="XM_009168111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRZ6"/>
    <dbReference type="GeneID" id="20317779"/>
    <dbReference type="KEGG" id="ovi:T265_03592"/>
    <dbReference type="CTD" id="20317779"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="14794" checksum="EE00AF0BDE1024AD" modified="2014-10-01" version="1">MSKIWASGNFIGRLPDGVSPASRARYFARIFFVAAQGSSKAHLLQLFRDRLSGDEPNTPGLISITKVLKVGLNCSALESVGNEVTKHEPNKVKRIRKGTSEAITTGTIQTTIDRSAIGIRLWIRNFAPKINLCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSZ1</accession>
    <name>A0A074ZSZ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent RNA helicase Ski2/MTR4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601980">
        <property type="protein sequence ID" value="KER18389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177864.1">
        <property type="nucleotide sequence ID" value="XM_009179600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSZ1"/>
    <dbReference type="STRING" id="6198.A0A074ZSZ1"/>
    <dbReference type="GeneID" id="20330257"/>
    <dbReference type="KEGG" id="ovi:T265_16092"/>
    <dbReference type="CTD" id="20330257"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12432" checksum="24AD6CFCC7C6564C" modified="2014-10-01" version="1" fragment="single">MLTELMLDGLFSPFTPAQLAGVLSCFVAEKSSGKHQRTQLRPDMAQALEAIQTKARFLARVATECRISSSHLSSDSADGASGNIPEVAALLNSRASALDDEQAYVDRFSGDLMEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUJ5</accession>
    <name>A0A074ZUJ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_13879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169211.1">
        <property type="nucleotide sequence ID" value="XM_009170947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUJ5"/>
    <dbReference type="GeneID" id="20328046"/>
    <dbReference type="KEGG" id="ovi:T265_13879"/>
    <dbReference type="CTD" id="20328046"/>
    <dbReference type="OrthoDB" id="6232656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="444" mass="51270" checksum="211133E44682B9B8" modified="2014-10-01" version="1" fragment="single">SVCFICDRPVDEPEPLTGPCGTYHGGCFRCNGCRRILSYDRYKVIQAKLYCEPNCEAYMNGHNDVAQKIDAFKKERYSKEKMPAHRSKLIQKCPKCLLEIGSNEYVTALDRNYHRECLSCRHCNRVLLESQYKAIEDFPCCIPDCRMEREATSCMSCMYGLKTYFATYSTGSPKVPSEPASPRYLSLRRTPSPRPRSISVSLSKPGHTAENPKICVANPERVARLQRKLEEIQTMALEKMNCYVCGKKVYPAERLSILKRIYHKTENDSSCWVAILNCFWPVQTFTINFPWRNLAAKNASHSWIQLYNLAVSHRWRRYLKMPFTTRLGSEYTIVRARLAIRFIIGPRKPARNLLIHHLRSSRSRFELAEQLSTANRRCTGDENLDEVWRNVRINVLAEFSPVRLTSPMKPNDRWKSSRPQVVNDARKSLAGGNEYDDARKSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUR9</accession>
    <name>A0A074ZUR9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LIM domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_13097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165418.1">
        <property type="nucleotide sequence ID" value="XM_009167154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUR9"/>
    <dbReference type="STRING" id="6198.A0A074ZUR9"/>
    <dbReference type="GeneID" id="20327265"/>
    <dbReference type="KEGG" id="ovi:T265_13097"/>
    <dbReference type="CTD" id="20327265"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000110">
        <property type="entry name" value="Nebulin related anchoring protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41789" checksum="AA38A778E8FD9DC3" modified="2014-10-01" version="1" fragment="single">IGITVTIPHSAGTFSSSHIAPTRFVRRVTRDFPPSSKRAGYRPSGPGAFSRFGTAISKGDQGLHPIRSYALSPPAPAMSLNKSCAQCKQIVYPLEQLKCLDQVWHRKCFRCEKCGMALNMQNYRGYDKKPYCSAHYPQPKRFTVIADTPEMQRVAQNTRVLSDATYRQDFYRTKGHSLQTIQSPQLPPLSQSSDTRPYQHHHNDYALDQDRNSTQSAPRMNSTGQPFRSWSTTSPSVSRSSYVGNGHHQPSMGNGSYTSNGYTGTYYSGQYGIQQGRRPDISTEFTEPSDNHFQPPTEVGYNTQTSDYRSSNPNTKYRAMYDYEAREDDEVTFIEGDIILNGDPITEGWMYGTVQRTGQFGMLPSNYVEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUZ9</accession>
    <name>A0A074ZUZ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597370">
        <property type="protein sequence ID" value="KER19034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177219.1">
        <property type="nucleotide sequence ID" value="XM_009178955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUZ9"/>
    <dbReference type="GeneID" id="20326210"/>
    <dbReference type="KEGG" id="ovi:T265_12042"/>
    <dbReference type="CTD" id="20326210"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="26742" checksum="2B1E1AE5D9E1B98E" modified="2014-10-01" version="1">MDTDKPVDVVATCVLSASNNRCCDTSNCAYSLDNISRKHSKANVTMCNSHPAVLVRRCAAAMTTHCSALKAGRKPNERPTHTRVVRRDKINKVNQSNVGTRSTAPANWPITNMALHRLIGGRANSRHTRYERCLGANRGNHAVDVYMASLLAGSVDLSPLAVQSTVIKTQCRAKVRKPNNGEWNVGSVVWVVVVPSAARLVMLISDTVTWMLWQNKSGQAQQTGHKHAWSSLLNKGLWVRIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWK5</accession>
    <name>A0A074ZWK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165927.1">
        <property type="nucleotide sequence ID" value="XM_009167663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWK5"/>
    <dbReference type="STRING" id="6198.A0A074ZWK5"/>
    <dbReference type="GeneID" id="20317417"/>
    <dbReference type="KEGG" id="ovi:T265_03230"/>
    <dbReference type="CTD" id="20317417"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="63"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="185"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="586"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER30277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="799" mass="88350" checksum="2ACC71A098187FEE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWU7</accession>
    <name>A0A074ZWU7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596661">
        <property type="protein sequence ID" value="KER30392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165806.1">
        <property type="nucleotide sequence ID" value="XM_009167542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWU7"/>
    <dbReference type="GeneID" id="20317316"/>
    <dbReference type="KEGG" id="ovi:T265_03129"/>
    <dbReference type="CTD" id="20317316"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11488" checksum="FCF8852762E7D6EA" modified="2014-10-01" version="1">MQQNGRKKFYSTCKGFAAESTLRIMGTGLEKLNSSLRAERKSYSGPKQLFNVLIKQKRSLTDSPDAVVLYRVGDDGLAPSSELDAVFERERFLAVVEPLFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWY6</accession>
    <name>A0A074ZWY6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="Znf106"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="100"/>
        </location>
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            <end position="237"/>
        </location>
    </feature>
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            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="615"/>
        </location>
    </feature>
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            <end position="228"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER31978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112102" checksum="CBDF72396E01712D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXX6</accession>
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    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXX6"/>
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    <dbReference type="KEGG" id="ovi:T265_01881"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11446" checksum="05D46A957E45C81A" modified="2014-10-01" version="1">MLSMRSSKLRLRGGPTMDRLHERRIRIFEDEQQPTILSSNDTGIFGSTSFCLEKTLVVIRPTEAYKRQPGTKLGQGLTPMSTALKTKPPNVQLTECLPMKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYD6</accession>
    <name>A0A074ZYD6_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">T265_12810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER32478.1"/>
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    <dbReference type="STRING" id="6198.A0A074ZYD6"/>
    <dbReference type="GeneID" id="20326978"/>
    <dbReference type="KEGG" id="ovi:T265_12810"/>
    <dbReference type="CTD" id="20326978"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="300"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="406" mass="45875" checksum="2C0C5048AF770EDB" modified="2014-10-01" version="1" fragment="single">EPETAQFPNSEPADLIWPKQPEVDVGSSDAKEEGTPGKDTENKQFGAEDFASIIVEAVVNNTALLPCRPIKKSAEGVGWDATNKGTLLWKRASTNDYLIHDNRRTHPDTRFILDMSSFDQTIMDLRIDNVQQADEGTYICLYSTGQHVYKRKIRLNVLVPPIIYENSSSPTRVVVQEGDDTVLHCKAWGVPQPNVTWYLLGQDGSSIQLGRLANSPRFTVEANHLQIFNVTRTMNGLYKCVAQNGLERMASRVIELDVHCKIRIYRLVIDQVAVDLFADLGNRFADISSPFEETSSMRCPTIPPTIRMANTKIGQLLYRTTMVRALITGNPINRFHWEFEQRPIYGPNSNCLVPMPNEKYCMIVDTMGSLQKELKTTLFITNLTMHDYGLYTCVVETPYGIFRNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZF8</accession>
    <name>A0A074ZZF8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164854.1">
        <property type="nucleotide sequence ID" value="XM_009166590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZF8"/>
    <dbReference type="GeneID" id="20327144"/>
    <dbReference type="KEGG" id="ovi:T265_12976"/>
    <dbReference type="CTD" id="20327144"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="23460" checksum="36309E5F891E0B5B" modified="2014-10-01" version="1" fragment="single">SRLPLSCVPGYSKGCVVAWPLRTNDVKRLQVSNHRCLRIVADFGWRQRVSDEVIRKQVFGCAAGTSIRENIQHQRLRWLSHVLRMPKNRLPRRVLFSVPPSGWLEPRGWVPVIPFEIGWRRCEKWRLIDVSGVRAVNFYCLIERLERLWAKKRLGEADNHDEICVLLRLMYANYTRLVISIVNSKPTLDRIMSATDLHCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0E0</accession>
    <name>A0A075A0E0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163343.1">
        <property type="nucleotide sequence ID" value="XM_009165079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0E0"/>
    <dbReference type="STRING" id="6198.A0A075A0E0"/>
    <dbReference type="GeneID" id="20315306"/>
    <dbReference type="KEGG" id="ovi:T265_01118"/>
    <dbReference type="CTD" id="20315306"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="10430" checksum="8E49B19F4894BF90" modified="2014-10-01" version="1">MADPRLRKLTISTNVVKRIAKEKARYEEEVVQQTNLYDAKVTEGADEYEIKMAKAILDESKMMLPDCQIRLDKALFALNELLQVLFPAAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0K2</accession>
    <name>A0A075A0K2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163058.1">
        <property type="nucleotide sequence ID" value="XM_009164794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0K2"/>
    <dbReference type="GeneID" id="20315087"/>
    <dbReference type="KEGG" id="ovi:T265_00899"/>
    <dbReference type="CTD" id="20315087"/>
    <dbReference type="OrthoDB" id="10583621at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11432" checksum="12D0E56FFC671B80" modified="2014-10-01" version="1">MIGCWVQTFDQSDLGLMPDRQASRTFDQSCVGWSSRPTTTNPPLRTTTLPNNALMISPRLVMKRLQSNCPAQRTSQRPSTLSELLTFSSIERRKLFWNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0N9</accession>
    <name>A0A075A0N9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162976.1">
        <property type="nucleotide sequence ID" value="XM_009164712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0N9"/>
    <dbReference type="GeneID" id="20326798"/>
    <dbReference type="KEGG" id="ovi:T265_12630"/>
    <dbReference type="CTD" id="20326798"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11906" checksum="FC4A894D57D1DAD3" modified="2014-10-01" version="1" fragment="single">MYCTEAATNLVFVRNLSANHVYDILHLSALHKGRLIFRLVRCSRYRSIYSHRKPLTRLLKSVCPKNDETSRGLSKSLRLDRTVRCTKVRLIFHWYDARDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1F4</accession>
    <name>A0A075A1F4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166831.1">
        <property type="nucleotide sequence ID" value="XM_009168567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1F4"/>
    <dbReference type="GeneID" id="20318146"/>
    <dbReference type="KEGG" id="ovi:T265_03960"/>
    <dbReference type="CTD" id="20318146"/>
    <dbReference type="OrthoDB" id="6270660at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122708" checksum="07FFC80E32533BA3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1G3</accession>
    <name>A0A075A1G3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596983">
        <property type="protein sequence ID" value="KER21219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175037.1">
        <property type="nucleotide sequence ID" value="XM_009176773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1G3"/>
    <dbReference type="STRING" id="6198.A0A075A1G3"/>
    <dbReference type="GeneID" id="20324575"/>
    <dbReference type="KEGG" id="ovi:T265_10407"/>
    <dbReference type="CTD" id="20324575"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="12259" checksum="576B07EC7EE4FD4D" modified="2014-10-01" version="1">MLYPKEDKRNKRLNYACRNCDYTQEADNPCVYINKLEQEVDELALIVPDVVHDPTLPRTEDHKCRNCGKQEAVFFQSQTLKAEENMRLYYVCTNLECLHKWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1G8</accession>
    <name>A0A075A1G8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163033.1">
        <property type="nucleotide sequence ID" value="XM_009164769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1G8"/>
    <dbReference type="STRING" id="6198.A0A075A1G8"/>
    <dbReference type="GeneID" id="20315062"/>
    <dbReference type="KEGG" id="ovi:T265_00874"/>
    <dbReference type="CTD" id="20315062"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="108"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49888" checksum="335A6C4C5AEF9ACC" modified="2014-10-01" version="1">MPLTSISHYFLQRLQPGTGGVTGTPSWKAHITNTQTLRDLLHAFLPIHALSTWHCNTLSVPSYHATIKKHEGWDTARFPKPRQGKSRASGRVRTTGLPLSRLATSTLGMNEIFPGLWIGSCPFKENAPNLLRFGIKSILTLDALPLSDGVFDCFNRKFIRLLDEPSQDVLDILEEALDFIDLSLTTGGILVHCAMGVSRSATIVIAYVMRKNKLSYDSALEIVMKKRLVYPNIGFVNQLKLFEVMKWKVDRKSPVYTQYASIRTFRGSNIAYNRTDSSTTIATRDPVQPATFKCRKCRRALFSSANLVSHCLPDSTTPSSESVDVDGEDNVEISTVLIKGITLNAVPTPCTRDELFTDPLEWTRPYTHEVEGKLYCPGCQAKVGSFNWCGERCVCGTWVTPAFHFNRNHLDRIDRRLASSQSTTQPLFSAPNKVEPTSTSSSPSVAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A206</accession>
    <name>A0A075A206_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_03864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166709.1">
        <property type="nucleotide sequence ID" value="XM_009168445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20318051"/>
    <dbReference type="KEGG" id="ovi:T265_03864"/>
    <dbReference type="CTD" id="20318051"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="198"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="339"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="486"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="623"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="740"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1246"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1310" mass="148095" checksum="758323B82D9DCB6E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A224</accession>
    <name>A0A075A224_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162838.1">
        <property type="nucleotide sequence ID" value="XM_009164574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A224"/>
    <dbReference type="GeneID" id="20314913"/>
    <dbReference type="KEGG" id="ovi:T265_00725"/>
    <dbReference type="CTD" id="20314913"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="12639" checksum="B56923D38CF3D9F3" modified="2014-10-01" version="1">MSTANNSRRIYTGCRNRPRDITVLYSEKQPHTRSKAREPVIYRSVRKLRSRDRMTIDASKSLLWSSANADGKYSRTKEEFPFEMPCLNEYQRTASYGILLINLLYPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A295</accession>
    <name>A0A075A295_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162301.1">
        <property type="nucleotide sequence ID" value="XM_009164037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A295"/>
    <dbReference type="STRING" id="6198.A0A075A295"/>
    <dbReference type="GeneID" id="20314480"/>
    <dbReference type="KEGG" id="ovi:T265_00292"/>
    <dbReference type="CTD" id="20314480"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="511"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="901" mass="100311" checksum="F8579F208E3609A1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2N2</accession>
    <name>A0A075A2N2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162151.1">
        <property type="nucleotide sequence ID" value="XM_009163887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2N2"/>
    <dbReference type="GeneID" id="20314367"/>
    <dbReference type="KEGG" id="ovi:T265_00179"/>
    <dbReference type="CTD" id="20314367"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14784" checksum="8AA53C28F94DD87D" modified="2014-10-01" version="1">MSSEDIKYDFPGLVHRSLQWGQVENSRDSSNQRGHSSLPRGITKQSRFQRRVCGIYGSKLPASTFSETKQVPKTLDEFIHNQSRGIGDVEVLRVVFRRNNSSKLDELIIPHRLHWLGHVSACQSNHFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2P5</accession>
    <name>A0A075A2P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163689.1">
        <property type="nucleotide sequence ID" value="XM_009165425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2P5"/>
    <dbReference type="GeneID" id="20315587"/>
    <dbReference type="KEGG" id="ovi:T265_01399"/>
    <dbReference type="CTD" id="20315587"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7159" checksum="3BD96FF37143B66C" modified="2014-10-01" version="1">MNLIFIEAVQHHRDISQLAVHIEERYRNHPDMYSTSQVTCLRSFSTQTHIKIGVVAGVNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Q7</accession>
    <name>A0A075A2Q7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162595.1">
        <property type="nucleotide sequence ID" value="XM_009164331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Q7"/>
    <dbReference type="GeneID" id="20314715"/>
    <dbReference type="KEGG" id="ovi:T265_00527"/>
    <dbReference type="CTD" id="20314715"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7068" checksum="F8A4ABEA870254C9" modified="2014-10-01" version="1">MGIPLVKASQVHEHILAQFCGATLLAGRFSSPDEYALRNTKSTKPQVLKRPNLFIVPRDLAPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3C8</accession>
    <name>A0A075A3C8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_00028</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Lipid-anchor</topology>
            <orientation evidence="2 13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161949.1">
        <property type="nucleotide sequence ID" value="XM_009163685.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A3C8"/>
    <dbReference type="GeneID" id="20314216"/>
    <dbReference type="KEGG" id="ovi:T265_00028"/>
    <dbReference type="CTD" id="20314216"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="15">
        <location>
            <begin position="4"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="16">
        <location>
            <begin position="1118"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="783"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149928" checksum="860FDDF118367900" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3V0</accession>
    <name>A0A075A3V0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162197.1">
        <property type="nucleotide sequence ID" value="XM_009163933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3V0"/>
    <dbReference type="STRING" id="6198.A0A075A3V0"/>
    <dbReference type="GeneID" id="20314413"/>
    <dbReference type="KEGG" id="ovi:T265_00225"/>
    <dbReference type="CTD" id="20314413"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="675" mass="74769" checksum="207AE1D43E947612" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A412</accession>
    <name>A0A075A412_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165952.1">
        <property type="nucleotide sequence ID" value="XM_009167688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A412"/>
    <dbReference type="GeneID" id="20317442"/>
    <dbReference type="KEGG" id="ovi:T265_03255"/>
    <dbReference type="CTD" id="20317442"/>
    <dbReference type="OrthoDB" id="10062329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="379" mass="43452" checksum="92EB743F5DD251AA" modified="2014-10-01" version="1">MRLLKILRQPTTGCTFIGVHQVGAVSEFLSTLRSTCTHLQIILVFARDSTESLHTEDFVDPTTTAHTQTIESLWHVYKMRNKRQYGTHRSLVDSYLCEFVWRQRNTLICKSIWFSRVTTESPVYGILQLNVLHTGRLMIQLERYSSHINEVLCASVQNFLTMNVSRRTKIVKLYYSLGESATSALRGYKTKHGLIKDPFTVSTIARLIAEFESIGPVLDFPGKGKKSLSDERAPIVQNAVEQLQSQSTMASSSITQRALYCETPPSSQQDSAPPHYTNQVRTYLREQFSDERVIACRFPNFWPARSSDLAPLNYWFWGMIKARVHQANKPKDSVELRARIEEECARMTPEEVKHTVSHISCRLQLVIEERGALFQYILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4I9</accession>
    <name>A0A075A4I9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TMPIT-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162054.1">
        <property type="nucleotide sequence ID" value="XM_009163790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4I9"/>
    <dbReference type="GeneID" id="20314321"/>
    <dbReference type="KEGG" id="ovi:T265_00133"/>
    <dbReference type="CTD" id="20314321"/>
    <dbReference type="OrthoDB" id="2015098at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 120 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44992" checksum="CCE5ADE362E7DCE6" modified="2014-10-01" version="1">MPDFDKIQEEFEKQWRIMKGKHSSYLSSVETMKTAQSNCSQSVKHCKSYMQFLNNEISRLEKSATTEEKKKLAGVKLELQRKEVEMRNVEDVLPRRPGLYLRIVLGALNISLSSKQDKFAYKNDYEQFKIVVSAICAVLTFLLYFFIQSRVLDTVFHFLLVWYYCTLTIRERILIANGSRIKGWWNIYHFISTASAGIMLIWPRSQSYDEFRDQFMLFSLCMSIVHCFQYQYQIGCLYKLRALGEIHPMYITIDGFKSWMFKRLTFILPFLYGVYAFEMYNAYCLYEISRQPYCQEWQVLAVALLDAIRAMGNLITMGLVIRQKFRSISAVEFYRLKSQYHFSQPSKGSSGDESVFAVNKGDVIESNLLPPDETCAVQRQPTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A532</accession>
    <name>A0A075A532_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162831.1">
        <property type="nucleotide sequence ID" value="XM_009164567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A532"/>
    <dbReference type="GeneID" id="20314906"/>
    <dbReference type="KEGG" id="ovi:T265_00718"/>
    <dbReference type="CTD" id="20314906"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19090" checksum="22141BC0CE9E4DDF" modified="2014-10-01" version="1">MYLSKPSGQDGMNFEERSDGVAQFPGKFMSVRGSNPTSATRLPLSRLGQPGSIPALVLPSGDMAARHRKGATAERFYLYEIKAAGILTLSNSPDTSFPYSFRYLPGQYDFTPRPPRTTITRSAGPRCSPLAFLAWLDLVERSSSQCSPRDDCSTQTRTPRQGGSFRSSSESIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5B3</accession>
    <name>A0A075A5B3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162694.1">
        <property type="nucleotide sequence ID" value="XM_009164430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5B3"/>
    <dbReference type="GeneID" id="20314790"/>
    <dbReference type="KEGG" id="ovi:T265_00602"/>
    <dbReference type="CTD" id="20314790"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15301" checksum="DA1937300C7A2F7F" modified="2014-10-01" version="1">MCVILRNRFSYIVPTTSLVTLNDINLVISHTKPCTVVHRAQLLFYANDLSIKMTLVFNTDASLPYNHDLFESLIVKKRVKLANAARALQIRAFTSSVTLQSELIQLPRYVKCSTTSSASPWIRMNTLFLKRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6D6</accession>
    <name>A0A075A6D6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165141.1">
        <property type="nucleotide sequence ID" value="XM_009166877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6D6"/>
    <dbReference type="GeneID" id="20316786"/>
    <dbReference type="KEGG" id="ovi:T265_02598"/>
    <dbReference type="CTD" id="20316786"/>
    <dbReference type="OrthoDB" id="6245656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="34136" checksum="2854BEEC8CC21297" modified="2014-10-01" version="1">MHDAIQVQPDHCYTIHHNFKEHLKSNYHRERKSNIINGLHCVLDFNPTLHMSWQLTDSPHEKTEASALTWIDRRLNSNIHCRSDSHTHEMAQHEGERGKIGSTSGDSGKLPPILTNCVLKDPPFASLAVLSTFAEYHKCRDWTTRRGALKSIIFCYTGAAGRFCGTIGEKTSLKMLRESKFIDWLKAKNVSPLVFGGVHTQIFHSVSNDRRQITVDLYIDHFIPRLAIALRKYAQIPELTAKTIEEILVLPVFYSTSSEVNVAPSSVVIDFVTVNRGLFAAHDIKNRVWGKRTTKSNRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6X6</accession>
    <name>A0A075A6X6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164801.1">
        <property type="nucleotide sequence ID" value="XM_009166537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6X6"/>
    <dbReference type="GeneID" id="20316511"/>
    <dbReference type="KEGG" id="ovi:T265_02323"/>
    <dbReference type="CTD" id="20316511"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="16836" checksum="6D4A036126278308" modified="2014-10-01" version="1">MEHISVPKCVINSEKSMGDMQFEIAVGNPEAPLDSSNWPEAKNEVNIKLFVRSFLAVVRIIVPFHDSSGENPQAIDYQDNEHEYIVYDEVWRPKMCWEHACPLMLRFLSVLATSLFLQFLGAMPKCFHQHAYSKPSFILSDLLSTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7G0</accession>
    <name>A0A075A7G0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162085.1">
        <property type="nucleotide sequence ID" value="XM_009163821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7G0"/>
    <dbReference type="STRING" id="6198.A0A075A7G0"/>
    <dbReference type="GeneID" id="20314352"/>
    <dbReference type="KEGG" id="ovi:T265_00164"/>
    <dbReference type="CTD" id="20314352"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="48411" checksum="0775BB48A712B596" modified="2014-10-01" version="1">MAENHNRSNDSEQTFAEIESWLESLSVESTVNTSRLEQNLEEWLHLINDIASIRNIAFVTSGGTIAPLERRIVRFIDNFSTGSRGASSTEYFLRHGYAVVFFHRRGSLLPYLRTLKNCLSLDTMERIENQLTMDQHHCINYLDWFQLNSNGTDVSVSQAALGYLLPVLTAYSKYKRGLLTLTFETVEDYVVGLYVISKRLMQFVKNESRYKRSLCCYLAAAVSDFYLPLAQRSEHKIPSSASGDNSKPSTLCLDGSGLTIHLESVPKLLPPLILKWASGAFVVSFKLETDRSHLLSVAESRIVNAESHLVVANQLETRFEEVWLVHRLCDPQKCVREHIQVPKSNEGQTTVELEELLVSRRHVLKHEIPLSGFKVLAEKWSAGGQCTQQSLCLASVYKDNDDVISGRPVGKVLTRKNLQRSSTASLIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7L8</accession>
    <name>A0A075A7L8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172817.1">
        <property type="nucleotide sequence ID" value="XM_009174553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7L8"/>
    <dbReference type="STRING" id="6198.A0A075A7L8"/>
    <dbReference type="GeneID" id="20322861"/>
    <dbReference type="KEGG" id="ovi:T265_08682"/>
    <dbReference type="CTD" id="20322861"/>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20556">
        <property type="entry name" value="CYCLIN_CABLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="453"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="592" mass="65729" checksum="9F384FA0DA3EC004" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7Q8</accession>
    <name>A0A075A7Q8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596847">
        <property type="protein sequence ID" value="KER23509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172756.1">
        <property type="nucleotide sequence ID" value="XM_009174492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7Q8"/>
    <dbReference type="GeneID" id="20322809"/>
    <dbReference type="KEGG" id="ovi:T265_08630"/>
    <dbReference type="CTD" id="20322809"/>
    <dbReference type="OrthoDB" id="6220244at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8761" checksum="6693099ED12EC233" modified="2014-10-01" version="1">MCWTDGQDLVDSKNLCATPDEECGTFKPCCGRHLICKRLGSAGQCVRCARDHEHCNRSSECCLGVCMNHTCRHIMRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9U2</accession>
    <name>A0A075A9U2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163690.1">
        <property type="nucleotide sequence ID" value="XM_009165426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9U2"/>
    <dbReference type="GeneID" id="20315588"/>
    <dbReference type="KEGG" id="ovi:T265_01400"/>
    <dbReference type="CTD" id="20315588"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="27251" checksum="815F1DAABA083F94" modified="2014-10-01" version="1">MTDADDAFSAVDDHFHDRFLYTQETSEVVIKKTYSWMEESPMKNEQNNASVGQIREIRVDMKNVEFSGYGLQFTPQQPIAEAVEITKPHSVKRIQGVKLISRNQIATKRLVDNLGSKVQQCLAKAMSSCVDIKDRESCLLTAASFFFIRVHNFSAYGGMRHGRKFMEAWYSTVDSINKCIELDPISARLRVKDQHLNRNIQAESNISCTRNNLESDQQRSQARTQSNQGKRSLEHQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABB0</accession>
    <name>A0A075ABB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Negative elongation factor D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163219.1">
        <property type="nucleotide sequence ID" value="XM_009164955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABB0"/>
    <dbReference type="STRING" id="6198.A0A075ABB0"/>
    <dbReference type="GeneID" id="20326860"/>
    <dbReference type="KEGG" id="ovi:T265_12692"/>
    <dbReference type="CTD" id="20326860"/>
    <dbReference type="OrthoDB" id="511287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59745" checksum="174F49A8FA39BB9A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC09</accession>
    <name>A0A075AC09_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162835.1">
        <property type="nucleotide sequence ID" value="XM_009164571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC09"/>
    <dbReference type="GeneID" id="20314910"/>
    <dbReference type="KEGG" id="ovi:T265_00722"/>
    <dbReference type="CTD" id="20314910"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="195" mass="21513" checksum="D487A664F3812AB7" modified="2014-10-01" version="1">MIAGEKPIDLECADKDSASSPEDFALVVLWNMGSSGVLTGCLSVRRAWQLDYKRFITSRAESAKYNQIKFAMVREWSIIGNTDVIAFGNEDEGGKLPRFAVSTSRVKPMNSTISYYGLLESQTSGAYARSTSSYTLNRSVTIANHDWAPNTGCTPSTKWSGGNRLIDNESSMVKERSNYYCRLATDTIEAHPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADQ0</accession>
    <name>A0A075ADQ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170094.1">
        <property type="nucleotide sequence ID" value="XM_009171830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADQ0"/>
    <dbReference type="GeneID" id="20328225"/>
    <dbReference type="KEGG" id="ovi:T265_14059"/>
    <dbReference type="CTD" id="20328225"/>
    <dbReference type="OrthoDB" id="10615416at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9507" checksum="892FBC0FB73367F4" modified="2014-10-01" version="1" fragment="single">RRSSFNHVIHISRSHVLTGSSCNDFSDRSFTHRDIALLILQSLGAHHADTHVDWLLEQRVPKWKFHSPGEVYSSIELLINCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEQ2</accession>
    <name>A0A075AEQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169326.1">
        <property type="nucleotide sequence ID" value="XM_009171062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEQ2"/>
    <dbReference type="GeneID" id="20320109"/>
    <dbReference type="KEGG" id="ovi:T265_05927"/>
    <dbReference type="CTD" id="20320109"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11509" checksum="8F6CEDCE4BD681AE" modified="2014-10-01" version="1">MERPQCNLVHTTRALTLPKLFQNLNKRIIETADIGPKVRCPQLNKRLCMLRSGRQQSDFPPFPSENSDSADPYSNTTQETTLSVKEDALDIRVTRLSHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGJ4</accession>
    <name>A0A075AGJ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167483.1">
        <property type="nucleotide sequence ID" value="XM_009169219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGJ4"/>
    <dbReference type="STRING" id="6198.A0A075AGJ4"/>
    <dbReference type="GeneID" id="20318652"/>
    <dbReference type="KEGG" id="ovi:T265_04470"/>
    <dbReference type="CTD" id="20318652"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="378"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="607" mass="66773" checksum="820B72A5F900ACDA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHA9</accession>
    <name>A0A075AHA9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166705.1">
        <property type="nucleotide sequence ID" value="XM_009168441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHA9"/>
    <dbReference type="GeneID" id="20318047"/>
    <dbReference type="KEGG" id="ovi:T265_03860"/>
    <dbReference type="CTD" id="20318047"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38775" checksum="E2B809E8C5FE08CF" modified="2014-10-01" version="1">MPRLSIGHVCLLVLVFQNLLYTLCMRYGRSRNAPMFIISSMMVTSEAVKLLTCLVVLHSTGTLKHSYAQFLCNIWDSIKSCLPALIYLVQNRLLVAALGNLDAATFQVAYQLKLLTTALFSVLILRKPISLIQWFSLLLLFFGVAIVEPPSGSKENPMSVSQNPSLGLFYVVCASLLSGFACVYLELLFKNPHKSLWLRNIEVAGTSLVTGAIVQWISDGDLIKEKGYFYGFDWLVWILVGLHSFGGLIVAMVVKYANNMLKGFACSMSIVLSCIYSVLFLGVHLSPSFLIGACLVLISVVLYAAYPPRISCSPTVVKRNQATRPEMIQWLEREFTDRKLRGSEPDPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHM9</accession>
    <name>A0A075AHM9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166049.1">
        <property type="nucleotide sequence ID" value="XM_009167785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHM9"/>
    <dbReference type="STRING" id="6198.A0A075AHM9"/>
    <dbReference type="GeneID" id="20317511"/>
    <dbReference type="KEGG" id="ovi:T265_03324"/>
    <dbReference type="CTD" id="20317511"/>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="565"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="875" mass="96168" checksum="9CABB43C1E7626DE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI78</accession>
    <name>A0A075AI78_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165142.1">
        <property type="nucleotide sequence ID" value="XM_009166878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI78"/>
    <dbReference type="GeneID" id="20316787"/>
    <dbReference type="KEGG" id="ovi:T265_02599"/>
    <dbReference type="CTD" id="20316787"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10378" checksum="D61D34F8FD6804B5" modified="2014-10-01" version="1">MYRSTDIRNRALETAKKVELCIPAKTMKAAWLAYLRLSPSRHHSQAPLTRNVLSSDYQLLQYEFGIHPWRDNLLYEQGLSSSLTPLSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI94</accession>
    <name>A0A075AI94_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164945.1">
        <property type="nucleotide sequence ID" value="XM_009166681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI94"/>
    <dbReference type="GeneID" id="20316620"/>
    <dbReference type="KEGG" id="ovi:T265_02432"/>
    <dbReference type="CTD" id="20316620"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8724" checksum="D473E5EEB6F10D6E" modified="2014-10-01" version="1">MAVDSSARWRKPRGGQHMTWQKGVKEITKSVGVVGVVRLPGWGPRDPVCAWLEALQERAANRCQWRSCCQFLSRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIX6</accession>
    <name>A0A075AIX6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caspase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163764.1">
        <property type="nucleotide sequence ID" value="XM_009165500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIX6"/>
    <dbReference type="SMR" id="A0A075AIX6"/>
    <dbReference type="STRING" id="6198.A0A075AIX6"/>
    <dbReference type="GeneID" id="20315647"/>
    <dbReference type="KEGG" id="ovi:T265_01459"/>
    <dbReference type="CTD" id="20315647"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="193"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33081" checksum="F6622C201AC035F5" modified="2014-10-01" version="1">MSTDGTDSKLQYTSEVSPSQVNPIFQLSPTEISDPTLHYPIRECILSKQIYRGLCLIINQKDFSPETGQTCREGTDRDADRVERLFKMLGYNVQRYLNVNRNKLHRLLHDAATYDHSQFDSFVCVILSHGENGVIYATDGPVPTDVVIANFRGDQCITLTGKPKLFFIQACRGVQFDKGAAIPLATDAVGDVVITKLPVEADILIAHSTVPGYFAWRNSVVGSWFIQELCRILEEDYKGSTVHDLVTLLTVVARCVAYQYRSNTGQAGSHNMLQMTNYSSTLTRLMYLTVKPKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJF3</accession>
    <name>A0A075AJF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162921.1">
        <property type="nucleotide sequence ID" value="XM_009164657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJF3"/>
    <dbReference type="GeneID" id="20314973"/>
    <dbReference type="KEGG" id="ovi:T265_00785"/>
    <dbReference type="CTD" id="20314973"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="764" mass="87271" checksum="747185DC8125E413" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV12</accession>
    <name>A0A074YV12_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599248">
        <property type="protein sequence ID" value="KER18606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177647.1">
        <property type="nucleotide sequence ID" value="XM_009179383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV12"/>
    <dbReference type="STRING" id="6198.A0A074YV12"/>
    <dbReference type="GeneID" id="20326388"/>
    <dbReference type="KEGG" id="ovi:T265_12220"/>
    <dbReference type="CTD" id="20326388"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="16886" checksum="C999A93FFD434A6F" modified="2014-10-01" version="1">MAGPTQGMYIPPSAYGSGQGVMSNMPQYYPGQPQSHPQQSNPFYGVPTTNQPQIHPGAYPSHPPGPYSMQQMEASLPAPQAGTDPSSMYPSTAAAHTPGQHPSANTIAAEDPSTVQPPSYSQLPDRPAEDSQPATSTGNYPSTGYSQPQAALLEGQLISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWT2</accession>
    <name>A0A074YWT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_11921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KL597275">
        <property type="protein sequence ID" value="KER19241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177010.1">
        <property type="nucleotide sequence ID" value="XM_009178746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWT2"/>
    <dbReference type="STRING" id="6198.A0A074YWT2"/>
    <dbReference type="GeneID" id="20326089"/>
    <dbReference type="KEGG" id="ovi:T265_11921"/>
    <dbReference type="CTD" id="20326089"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER19241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130241" checksum="7E5D8C945EF39012" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYE4</accession>
    <name>A0A074YYE4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597133">
        <property type="protein sequence ID" value="KER19821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176436.1">
        <property type="nucleotide sequence ID" value="XM_009178172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYE4"/>
    <dbReference type="GeneID" id="20325670"/>
    <dbReference type="KEGG" id="ovi:T265_11502"/>
    <dbReference type="CTD" id="20325670"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12895" checksum="AF80D56F1F208FB8" modified="2014-10-01" version="1">MTPYHINFNGLHSEHRSIMIDHNRSSGHSPLYQTSELKSVVASSTFKCVSTGSSADTTTIIENRPQTLSRKFAVVFYVEPFLSRWDWIAELSRDYFLFRTTDHLRIPVEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYN6</accession>
    <name>A0A074YYN6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597142">
        <property type="protein sequence ID" value="KER19768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176492.1">
        <property type="nucleotide sequence ID" value="XM_009178228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYN6"/>
    <dbReference type="GeneID" id="20325716"/>
    <dbReference type="KEGG" id="ovi:T265_11548"/>
    <dbReference type="CTD" id="20325716"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7373" checksum="CEBDEDD9603FB9EF" modified="2014-10-01" version="1">MPVKTSNHIPFLNAPKLLAEGMVSSEKDITNKGSKNDGRKVADSISSISDPQAKDEATGSGTGLFRAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZS7</accession>
    <name>A0A074YZS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598438">
        <property type="protein sequence ID" value="KER18712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177541.1">
        <property type="nucleotide sequence ID" value="XM_009179277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZS7"/>
    <dbReference type="STRING" id="6198.A0A074YZS7"/>
    <dbReference type="GeneID" id="20330038"/>
    <dbReference type="KEGG" id="ovi:T265_15873"/>
    <dbReference type="CTD" id="20330038"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12382" checksum="72336CCB70C66AE1" modified="2014-10-01" version="1" fragment="single">MHRLIVKEFRGEFQGCGYGTVGFSATVFSGSTSDPLIPRTSKASCSFGDEELRRVRELREWFNSPGCPVEREPIIDHNDPSQSLQCTKPASLVKRLWCLQPEEFTSTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1C3</accession>
    <name>A0A074Z1C3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597024">
        <property type="protein sequence ID" value="KER20763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175492.1">
        <property type="nucleotide sequence ID" value="XM_009177228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1C3"/>
    <dbReference type="GeneID" id="20329411"/>
    <dbReference type="KEGG" id="ovi:T265_15246"/>
    <dbReference type="CTD" id="20329411"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7226" checksum="ED650A08A15FC142" modified="2014-10-01" version="1" fragment="single">ALGYPSRIDPSQTISWLGILDKTALPKTVGGTQAQRIDNLRLHDNETSASRGGAAFGHTSRKYRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1W5</accession>
    <name>A0A074Z1W5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_15185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175230.1">
        <property type="nucleotide sequence ID" value="XM_009176966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1W5"/>
    <dbReference type="STRING" id="6198.A0A074Z1W5"/>
    <dbReference type="GeneID" id="20329350"/>
    <dbReference type="KEGG" id="ovi:T265_15185"/>
    <dbReference type="CTD" id="20329350"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="347" mass="39005" checksum="7B4AEA0B5AD84499" modified="2014-10-01" version="1" fragment="single">MSRWITYASPETAGITYCEQGFIDIPRCNKPIQNGCLLTILLQYLLVCYLAMCVCTPFEYMVLFTIIANCVCLAMEVHLPSKDKRPLSEKLEMTEKYFMGIFTFEASLKIIALGFILHSGSYLRNVWNILDFIVVVTGLGQPGGDSVPLLPSGGMPAGRRKSVQLNDLDFKPYSDDNRVLVASLRFLCLSKFIPCSSIKFLTMFMTSGSGVNLRTLRAVRVLRPLKLVSGVPRARWPKWLEREPTDRKVRSSNPTSASRLPLSRLGQPGSIPALVFPAVGTIFEILQYIFVEETTHKFAENSSTAHERFRRSWSSSGRRSSRVSVNPMLCSFMKIYCDISNIVPTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z227</accession>
    <name>A0A074Z227_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597180">
        <property type="protein sequence ID" value="KER19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176708.1">
        <property type="nucleotide sequence ID" value="XM_009178444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z227"/>
    <dbReference type="GeneID" id="20325882"/>
    <dbReference type="KEGG" id="ovi:T265_11714"/>
    <dbReference type="CTD" id="20325882"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9836" checksum="AC9BB9E473C72F09" modified="2014-10-01" version="1">MADKPSHCLRRQSAAKYNFSNYQRFIPHYFVSHATSEAVTERPADCQSNDPSLMAKNQRIHINFTKGSRRETCDKHYSQSSDRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2L4</accession>
    <name>A0A074Z2L4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596977">
        <property type="protein sequence ID" value="KER21301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174952.1">
        <property type="nucleotide sequence ID" value="XM_009176688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2L4"/>
    <dbReference type="GeneID" id="20329289"/>
    <dbReference type="KEGG" id="ovi:T265_15124"/>
    <dbReference type="CTD" id="20329289"/>
    <dbReference type="OrthoDB" id="10341709at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="219" mass="24359" checksum="70D2B366561E66C3" modified="2014-10-01" version="1" fragment="single">LTISAQERDGVKLPWQQYYESQTGAQDTLPVDPCDVVLPLIRTVQISCNGWLVGCGPQGFSGNKINLFFRFENPTVRKACFHVVKDQVDRTIKSRFGEGTLSVVEFRITGNWVQPSTTSAGVTHSLGNILYNLRKNFYARWNIITRVYPVAAVHCLSISNTDDSKTVSLSVIFGMFQKNKQSANGLVGTTLRFSESKPTVTMDVPYLTTLTGLVVRQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3I4</accession>
    <name>A0A074Z3I4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597097">
        <property type="protein sequence ID" value="KER20077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176183.1">
        <property type="nucleotide sequence ID" value="XM_009177919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3I4"/>
    <dbReference type="STRING" id="6198.A0A074Z3I4"/>
    <dbReference type="GeneID" id="20325466"/>
    <dbReference type="KEGG" id="ovi:T265_11298"/>
    <dbReference type="CTD" id="20325466"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8605" checksum="F4115C22F3908AB4" modified="2014-10-01" version="1">MKNKLLSLHEPWHSAPNVMVKTVVGRTGSQGQCTQVRVEFLDDSHRSIIRNVKGPIREGDILTLLETEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3J8</accession>
    <name>A0A074Z3J8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596954">
        <property type="protein sequence ID" value="KER21603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174650.1">
        <property type="nucleotide sequence ID" value="XM_009176386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3J8"/>
    <dbReference type="GeneID" id="20329218"/>
    <dbReference type="KEGG" id="ovi:T265_15052"/>
    <dbReference type="CTD" id="20329218"/>
    <dbReference type="OrthoDB" id="6240246at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="36804" checksum="7CD5333E500E9ADC" modified="2014-10-01" version="1" fragment="single">MVKRSNSLSNLNQLLTISVRLVHYVELHTKDQFTTPVFQYRLEQHLISPWREPKKPVKAKLLITYTSLILSRASWWPYRVVERTDFGAVERCMAFPHVGPFFAVGIRDDDFAEKQFVVMTTKTLSDLQRVMHVMEAQLAVWRNANTPQPSELSPPSSALRKCASQHNLAPTGLSNQIETPASNVCSSVPQTTDTPRLNHKQETNGDYLVQIKRCECPPKWLPRLYLRDREQPKHSVHIHCEPEKLPESKYTKLSKKAQHAAENAGTTNRPTQGNRLTGQQNSNEKDWEVDVKYIRYDPRFGNVLDTEGSVYLYTAHQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4V5</accession>
    <name>A0A074Z4V5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="5">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_16129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:41733"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; enzymatically active. Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KL602977">
        <property type="protein sequence ID" value="KER18340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177913.1">
        <property type="nucleotide sequence ID" value="XM_009179649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4V5"/>
    <dbReference type="STRING" id="6198.A0A074Z4V5"/>
    <dbReference type="GeneID" id="20330294"/>
    <dbReference type="KEGG" id="ovi:T265_16129"/>
    <dbReference type="CTD" id="20330294"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER18340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11699" checksum="25572FF81878D3F5" modified="2014-10-01" version="1" fragment="single">FKDFAELWPEKFQNKTNGITPRRWLLLCNPNLSDLIMENLNGNDAWITDLTLINQLKSRVNDTALLRNLMRIKRDNKAKFAGYMEQNYGIHLNTASLFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4Z0</accession>
    <name>A0A074Z4Z0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596917">
        <property type="protein sequence ID" value="KER22128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174117.1">
        <property type="nucleotide sequence ID" value="XM_009175853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4Z0"/>
    <dbReference type="GeneID" id="20323865"/>
    <dbReference type="KEGG" id="ovi:T265_09697"/>
    <dbReference type="CTD" id="20323865"/>
    <dbReference type="OrthoDB" id="6284559at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="287" mass="31603" checksum="C8BCFF15164B86FA" modified="2014-10-01" version="1">MLGVSSEHNNGDQLRLGQPGSIPALVQPSGGIAVRHQKGVTAERLLRQQKLSAAYAQRTGRPLVTETTRDKPRASSQVGCPPRGSSRTRKPQTSRHSSPQTPFLTATTNASKQNAKKRMTHSQRINHASHSLEAALQSTRPVTTLSCDFEWLPPLLYPPDTLFDSSRSTNRMNSSSTRRSQSHSKTVSKPKFPQQCTSTTTTTATTNTEQNYVDPSTLSVDELEQILQRWFQAGYNLGQEHALQGRRKVFHIVVLESPCRGDKRRAKDARAGLADILTNQGMPSLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z530</accession>
    <name>A0A074Z530_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597036">
        <property type="protein sequence ID" value="KER20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175620.1">
        <property type="nucleotide sequence ID" value="XM_009177356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z530"/>
    <dbReference type="GeneID" id="20329437"/>
    <dbReference type="KEGG" id="ovi:T265_15272"/>
    <dbReference type="CTD" id="20329437"/>
    <dbReference type="OrthoDB" id="6267240at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19630" checksum="F721DB46E023DDCC" modified="2014-10-01" version="1" fragment="single">YAVVVGVIALAHIILVIVYFSKKDLFLTAVYDSMDDMTKNYKSIESGEVESVTFGLLMSMLECCGFNDANDFTAAGSQFTREDSYNGVQFASELLFSKTFQIQNVSRHIVLIFSSITDIQYPVPCCKTGSVGQNGDDCPQTFTVANSNIRTGCKQKIYERAVPLLDSVMLGSLVVLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z608</accession>
    <name>A0A074Z608_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598908">
        <property type="protein sequence ID" value="KER18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177598.1">
        <property type="nucleotide sequence ID" value="XM_009179334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z608"/>
    <dbReference type="STRING" id="6198.A0A074Z608"/>
    <dbReference type="GeneID" id="20330078"/>
    <dbReference type="KEGG" id="ovi:T265_15913"/>
    <dbReference type="CTD" id="20330078"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64598" checksum="48A79DEA390FBD1B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z691</accession>
    <name>A0A074Z691_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_10520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596996">
        <property type="protein sequence ID" value="KER21077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175177.1">
        <property type="nucleotide sequence ID" value="XM_009176913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z691"/>
    <dbReference type="STRING" id="6198.A0A074Z691"/>
    <dbReference type="GeneID" id="20324688"/>
    <dbReference type="KEGG" id="ovi:T265_10520"/>
    <dbReference type="CTD" id="20324688"/>
    <dbReference type="OrthoDB" id="1740355at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057060">
        <property type="entry name" value="MBTPS1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057032">
        <property type="entry name" value="MBTPS1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF7">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23094">
        <property type="entry name" value="MBTPS1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23090">
        <property type="entry name" value="MBTPS1_4th"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 third" evidence="8">
        <location>
            <begin position="310"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="7">
        <location>
            <begin position="475"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="7">
        <location>
            <begin position="604"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER21077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="825" mass="90785" checksum="105B0D682D7E7C63" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6K3</accession>
    <name>A0A074Z6K3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597585">
        <property type="protein sequence ID" value="KER18880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177373.1">
        <property type="nucleotide sequence ID" value="XM_009179109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6K3"/>
    <dbReference type="GeneID" id="20329938"/>
    <dbReference type="KEGG" id="ovi:T265_15773"/>
    <dbReference type="CTD" id="20329938"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11839" checksum="B933B0ADA05D81D6" modified="2014-10-01" version="1" fragment="single">MVPEPTFCRFTEKCEERAREKEATFHAYMDKYKYKKMVLYMDACFSGSIFQDILPSNVRIYATTSARDNEESYATFCNDKRIKDCPATEFSYAWITDSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6X5</accession>
    <name>A0A074Z6X5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CC2D1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596877">
        <property type="protein sequence ID" value="KER22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173416.1">
        <property type="nucleotide sequence ID" value="XM_009175152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6X5"/>
    <dbReference type="STRING" id="6198.A0A074Z6X5"/>
    <dbReference type="GeneID" id="20323329"/>
    <dbReference type="KEGG" id="ovi:T265_09150"/>
    <dbReference type="CTD" id="20323329"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="618"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112711" checksum="16A6B97716E6B555" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7M9</accession>
    <name>A0A074Z7M9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173062.1">
        <property type="nucleotide sequence ID" value="XM_009174798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7M9"/>
    <dbReference type="STRING" id="6198.A0A074Z7M9"/>
    <dbReference type="GeneID" id="20323055"/>
    <dbReference type="KEGG" id="ovi:T265_08876"/>
    <dbReference type="CTD" id="20323055"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="14981" checksum="BC6D9B9C74B2F8E1" modified="2014-10-01" version="1">MPKRGRGGSSGGKYRISLALPVGAVINCADNSGAKNLYMIAAFGIRGRLNRLPSAATGDLIVCSVKKGKPELRKKVLYAVVVRQRKAYRRKNGTFIYFEDNAGVIVNNKGELKGSAITGPVAKECADMWPKIASTASSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z829</accession>
    <name>A0A074Z829_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596858">
        <property type="protein sequence ID" value="KER23258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173006.1">
        <property type="nucleotide sequence ID" value="XM_009174742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z829"/>
    <dbReference type="GeneID" id="20323009"/>
    <dbReference type="KEGG" id="ovi:T265_08830"/>
    <dbReference type="CTD" id="20323009"/>
    <dbReference type="OrthoDB" id="10565154at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703966" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8362" checksum="15C815A0C4302FBD" modified="2014-10-01" version="1">MNVCALSLKIFLLCPRRVFAGSTPSIENSTSETSGVSQVSVGAIMDGCSRVRQFVDKHFNTISDASEGEEPKVEWPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z852</accession>
    <name>A0A074Z852_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596856">
        <property type="protein sequence ID" value="KER23283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172966.1">
        <property type="nucleotide sequence ID" value="XM_009174702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z852"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20322975"/>
    <dbReference type="KEGG" id="ovi:T265_08796"/>
    <dbReference type="CTD" id="20322975"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="51381" checksum="AED798EFB632529D" modified="2014-10-01" version="1">MSGAKCNSHEAHSINSRHMKLQVNLKMMRRCSLLIAFLFCTNHLLWLDAVGVHNWSSLFNNNPSKNWVVLVAGTNTWENYRHQADVFDAYHVVRKNNVPAENIITFAYDDIANNPRNPFKGQVFHDCMHEDVYQGVVIDYRGKDVTRDNFVKVSKGDEKLAANKKKVLKCGPDDNVFIFYSGHGLVSRISLVAEEYNKLVLYVEACYSGSLFRNILPRNVGIYVTTSAKENEQSWSIFCDEKYFDVCLASEYAYAWIGDSQYHDLKTRTLDQQYQEVRKRTWHSHVMKYGEMAIGSLLVGQFQGHYDLPNHRNDGTIPANAVDRKPSFQAHLFSKSRRLMEATMEQEHETAWRKLHRAIQLGQIVKETTRDIVVYVTSHHKPTLDGLSKRDELMCFRAVFDQFRTHCFTIQQVREVAQHTTHLMALCKAGYKAETLIYSVYNVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8H3</accession>
    <name>A0A074Z8H3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14647</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172846.1">
        <property type="nucleotide sequence ID" value="XM_009174582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8H3"/>
    <dbReference type="STRING" id="6198.A0A074Z8H3"/>
    <dbReference type="GeneID" id="20328813"/>
    <dbReference type="KEGG" id="ovi:T265_14647"/>
    <dbReference type="CTD" id="20328813"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="191" mass="21266" checksum="877CF2CD46CD714A" modified="2014-10-01" version="1">MSAYPISFVTGNKNKLAEVIKILGHEYTGKLTAVDLDLPELQGTIEDIARQKCLSASNVITGPVLTEDTALSFQALNGMPGPFIKWFLKAVGPDGLPRLLADFDDKRATAICTFAFCPGFGQKVHLFTGRTEGRIVAPRGPRDFGWDPVFQPDGFDLTYAEMDKATKNTISHRYKALMEVKRYLDEEYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8N8</accession>
    <name>A0A074Z8N8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172677.1">
        <property type="nucleotide sequence ID" value="XM_009174413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8N8"/>
    <dbReference type="STRING" id="6198.A0A074Z8N8"/>
    <dbReference type="GeneID" id="20322747"/>
    <dbReference type="KEGG" id="ovi:T265_08568"/>
    <dbReference type="CTD" id="20322747"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="57165" checksum="22C7DBFEAB78B554" modified="2014-10-01" version="1">MDAVPLDIIAPIASSRIITPVIKGSNKRSVIKTNGLALDDFIDNLVSGKEKGVKTPILREADMINLCQLTKHVLMSQPVLLELEGPLKVCGDVHGQFRDLLRLFDLCGSPETTNYLFLGDYVDRGKQSLETICLLFAYKVKYPTTFFLLRGNHECQAITRIYGFFDECKRRFNVKLWKCFLDVFNCLPVAAVIENQIFCCHGGISPEFLKQDIANLEDLKQKIRSIPRPAEVPEDGVVCDLLWADPLNPELLDNETEEVPQIFQETGFAPNERGVSYVFSPEVVDRFLTRFGLDLMVRAHQVVEDGYEFFANRSFVTIFSAPNYCGEFDNAGGIFCLSRSVNYRPATNEEEIDLEGSFQILYPEARKRSTVKRPSVTNTLPDEPHRGDYQQVSSQVRILPPGDLAQYQPLHIPLQQPLDHQRYAAAIWTETDNKNATDIGWQPYLVVSPTRRSEDHAVPILEGLSNLVAVAQSSYSLQVAWQPGTERALEQNKKDLHWVYLATGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W4</accession>
    <name>A0A074Z8W4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597162">
        <property type="protein sequence ID" value="KER19650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176606.1">
        <property type="nucleotide sequence ID" value="XM_009178342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8W4"/>
    <dbReference type="GeneID" id="20325804"/>
    <dbReference type="KEGG" id="ovi:T265_11636"/>
    <dbReference type="CTD" id="20325804"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9914" checksum="D6D84C270F493FD1" modified="2014-10-01" version="1">MRTYATLFIRLCLSGERKPLDENRPDRELGRTARPAILSTTGTLGMKEDSKEPHSNPDTQMGEDIRIGDLQAYDVTAMMTVIAVCLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Z9</accession>
    <name>A0A074Z8Z9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597152">
        <property type="protein sequence ID" value="KER19700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176547.1">
        <property type="nucleotide sequence ID" value="XM_009178283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8Z9"/>
    <dbReference type="GeneID" id="20325760"/>
    <dbReference type="KEGG" id="ovi:T265_11592"/>
    <dbReference type="CTD" id="20325760"/>
    <dbReference type="OrthoDB" id="10577072at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="270" mass="29615" checksum="771CEF00B7FC5992" modified="2014-10-01" version="1">MQERLTKNLPKPVAPPTTSPAPRAHNHEPSTSISGHPQMLSVTSTMPKRSTAYLRDTVTNQLTHEAVVEDGSTALPWTQSPTVQASHRNPFSCTTSRASSFRPSSTHLPEPILPHKIIRSPSNRATHFFDRISKPQIPLRNHSPCQVPPLKRPAYHKPGIPFRQLPTTPQPPPPPKPRPLVCTLPPPLNLNPLPSIKSTSLQTPQLLQPLSVSPSSYEPTSILPPGHHMQSSVVPEVGSVHVMLDNNAIPGWKKCRAAQILLCSTENFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBR4</accession>
    <name>A0A074ZBR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009173407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBR4"/>
    <dbReference type="STRING" id="6198.A0A074ZBR4"/>
    <dbReference type="GeneID" id="20328546"/>
    <dbReference type="KEGG" id="ovi:T265_14380"/>
    <dbReference type="CTD" id="20328546"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
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            <end position="600"/>
        </location>
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            <end position="262"/>
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            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="678" mass="77147" checksum="16576381F18A2440" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCE3</accession>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER23262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZCE3"/>
    <dbReference type="GeneID" id="20323013"/>
    <dbReference type="KEGG" id="ovi:T265_08834"/>
    <dbReference type="CTD" id="20323013"/>
    <dbReference type="OrthoDB" id="122464at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
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            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22410" checksum="13FBDC09799921EB" modified="2014-10-01" version="1">MQFVENYFSSQSEQSDEDDLYAARRKKEALKFENLMDDELDGILQRSSETRAIKQRQVHFASTNDSTQDATLPSGEQDDELYDEDEDELNAQWVRDNLPGGNSRNSDAVLNCPGCMTLLSVDSHRDGRLKTHYQSTNPINCVIDETCTAQASETHTRQSKRRRSSHKQILQGCREKSRKSFNCAGLNFPRRFPPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCY3</accession>
    <name>A0A074ZCY3_OPIVI</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZCY3"/>
    <dbReference type="GeneID" id="20321537"/>
    <dbReference type="KEGG" id="ovi:T265_07358"/>
    <dbReference type="CTD" id="20321537"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
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    </dbReference>
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        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="311"/>
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        </location>
    </feature>
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            <end position="277"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="382"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="549" mass="59786" checksum="67190237D5CCBD73" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD0</accession>
    <name>A0A074ZDD0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596985">
        <property type="protein sequence ID" value="KER21200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD0"/>
    <dbReference type="GeneID" id="20324594"/>
    <dbReference type="KEGG" id="ovi:T265_10426"/>
    <dbReference type="CTD" id="20324594"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="12716" checksum="095FCDE74A1D5FBC" modified="2014-10-01" version="1">MTGGLMGRQRIEKACSAATVSPESTDSNPILRLPASTVEVPLTVDKFKNVEAPARPTSSSERQPLTDKNKTDPGNLGKSLDPVYQSLLAAVSLYASDVFRSQDDAFHTKRTILLGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE42</accession>
    <name>A0A074ZE42_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596964">
        <property type="protein sequence ID" value="KER21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174775.1">
        <property type="nucleotide sequence ID" value="XM_009176511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE42"/>
    <dbReference type="GeneID" id="20324374"/>
    <dbReference type="KEGG" id="ovi:T265_10206"/>
    <dbReference type="CTD" id="20324374"/>
    <dbReference type="OrthoDB" id="6269593at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="663" mass="75688" checksum="45A2DFD91CD583DD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE73</accession>
    <name>A0A074ZE73_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagellar radial spoke RSP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172295.1">
        <property type="nucleotide sequence ID" value="XM_009174031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE73"/>
    <dbReference type="STRING" id="6198.A0A074ZE73"/>
    <dbReference type="GeneID" id="20328684"/>
    <dbReference type="KEGG" id="ovi:T265_14518"/>
    <dbReference type="CTD" id="20328684"/>
    <dbReference type="OrthoDB" id="313308at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009290">
        <property type="entry name" value="Radial_spoke_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648">
        <property type="entry name" value="FLAGELLAR RADIAL SPOKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21648:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06098">
        <property type="entry name" value="Radial_spoke_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="444" mass="51014" checksum="D1CC2658CE9E1FE4" modified="2014-10-01" version="1" fragment="single">MQAPSGEDGPAHYEAISRRRYLEMTSKCAELRKTMAKQRAATARKFLQEQRAGDAKGSLIGPGCMAFARSSVHVQTGLYLEELTEQIEQDDFATQTDYFLDRPPTPLFVPAKTGVDVATQIYENDLFDFELEVQPILEVLCGKTIEQALLEVAEEEELADLRCQQQVLQEIHNADLAEVARLEDRNRRYEKIDCMVFLELCPTLRPKEGYKGLGQFAEDTTRLPTFEYPVLNREEKQRRKVQYEKAMKLARETAEKIAAKAFTKAYLSPLMKSTFEQLLERGYFYDSVEHVSQHEVPSSFTFTLFFTIRLSNKLWLYGSETSVLNTDAMLSMMTYWNGKRYRFMCFLLQAIRQRHHEFRELGRAICEKACIRQVLPSLRTEVANYVIDRSARLALQRLELAAASTREIREAVNVEILNDAIYDVALEVQAQKEAEEAAENAETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEE2</accession>
    <name>A0A074ZEE2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596770">
        <property type="protein sequence ID" value="KER25641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170598.1">
        <property type="nucleotide sequence ID" value="XM_009172334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEE2"/>
    <dbReference type="STRING" id="6198.A0A074ZEE2"/>
    <dbReference type="GeneID" id="20321110"/>
    <dbReference type="KEGG" id="ovi:T265_06931"/>
    <dbReference type="CTD" id="20321110"/>
    <dbReference type="OrthoDB" id="6243274at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="386" mass="42331" checksum="7C6EC3DCA019FA7A" modified="2014-10-01" version="1">MNSVNSGQHVETDGEAEEELQSNGRILPVASTPNEQNPATRPTIVSNKEEDHQVPVRASDGGANTETVSLSRATESRVKYSSQESRASADVEDPLTHFPLYDLRKQNYPQPEAKSLPTAQQDGALHQVGPGHLRKRIHPMCDPHGQNRSNDEDEIEDQQSLQCRSSSSKWCSTCKKWCRTCPRRLRPPQWLTRGLMFLYRHLSAMTTYALFVLAVYSTILSIMPNVALPPICRRVAVPEDNQKQTVNGSTATISTTIAVESADLTEGPGYSLDPNYVEALECRRGAALSVIIYYAFGFVCGELMELLHLPGLLGAATADKPGPLEVGPEFGMLAGPASRRDLIGQQSGPNSQSFPSIGQMPVANGASRTRQNFQKVMTAYATYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF50</accession>
    <name>A0A074ZF50_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172007.1">
        <property type="nucleotide sequence ID" value="XM_009173743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF50"/>
    <dbReference type="STRING" id="6198.A0A074ZF50"/>
    <dbReference type="GeneID" id="20322228"/>
    <dbReference type="KEGG" id="ovi:T265_08049"/>
    <dbReference type="CTD" id="20322228"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="545" mass="61490" checksum="7B3EF45685889B1F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFE0</accession>
    <name>A0A074ZFE0_OPIVI</name>
    <protein>
        <recommendedName>
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            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07956</name>
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    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KL596813">
        <property type="protein sequence ID" value="KER24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009173627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFE0"/>
    <dbReference type="STRING" id="6198.A0A074ZFE0"/>
    <dbReference type="GeneID" id="20322135"/>
    <dbReference type="KEGG" id="ovi:T265_07956"/>
    <dbReference type="CTD" id="20322135"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="705" mass="78461" checksum="4572309D8255AE85" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG11</accession>
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        <recommendedName>
            <fullName evidence="7">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
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        <name evidence="5" type="ORF">T265_14067</name>
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    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170129.1">
        <property type="nucleotide sequence ID" value="XM_009171865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG11"/>
    <dbReference type="STRING" id="6198.A0A074ZG11"/>
    <dbReference type="GeneID" id="20328233"/>
    <dbReference type="KEGG" id="ovi:T265_14067"/>
    <dbReference type="CTD" id="20328233"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF36">
        <property type="entry name" value="CENTRIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="802"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="919"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="108506" checksum="99223F7F3A01624E" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGB4</accession>
    <name>A0A074ZGB4_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170008.1">
        <property type="nucleotide sequence ID" value="XM_009171744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGB4"/>
    <dbReference type="STRING" id="6198.A0A074ZGB4"/>
    <dbReference type="GeneID" id="20328202"/>
    <dbReference type="KEGG" id="ovi:T265_14036"/>
    <dbReference type="CTD" id="20328202"/>
    <dbReference type="OrthoDB" id="6279422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="383" mass="42273" checksum="CEA0CC2C218CC451" modified="2014-10-01" version="1" fragment="single">MCQFGSRARKFKRPAQIGSKPRLTYTLNEPKSQITSSSTTLWDSRNLTYSHNEWTIVSINLVSTTDYKCGKPHTIRVNGTPHSSILQICPRTMISSKNKRLWTSDSVHDGVWNTALVDLLNPVASDYKLILEGTIPAGYPDARICVDNITSYTEPCSALQKTAAVVSNHWSWAQYFGITFITALILGLTIPIVFLVILIWACRRRHHNMNSPYTDNKLFSTNLWYYIGGKEIHDDPTGFRGASSLIRSNKHCNTSSGAGTLRNNTQIVPDVMDLPDVVIPGGRVVSFNYSGNTLGPGGTLRHMSQTNNQLMQSTNCFNTGLTMGTVSSQSSGTPATTVGRSGPDGVLQPDPNFNFQQQQQQQQQQQQAQPAPSDPMTDIVDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH40</accession>
    <name>A0A074ZH40_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173723.1">
        <property type="nucleotide sequence ID" value="XM_009175459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH40"/>
    <dbReference type="GeneID" id="20328993"/>
    <dbReference type="KEGG" id="ovi:T265_14827"/>
    <dbReference type="CTD" id="20328993"/>
    <dbReference type="OrthoDB" id="6261373at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="536" mass="59582" checksum="74649F5AF7910AC7" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHA5</accession>
    <name>A0A074ZHA5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169637.1">
        <property type="nucleotide sequence ID" value="XM_009171373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHA5"/>
    <dbReference type="GeneID" id="20320354"/>
    <dbReference type="KEGG" id="ovi:T265_06172"/>
    <dbReference type="CTD" id="20320354"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="28169" checksum="49BB9D48CBA96E4A" modified="2014-10-01" version="1">MAHSSDTFSSSHIVPISFVRWATRGFPPSLKRAGYRPSGLGVFSRFGTVHHQRQHDISVQHQCFTVAHQYGYFIPYFFFRSAIKVYIPFARMHYLHRLCCRRPAELLFEVRTIRVLNQSLWLKSLTARQRCLAGKCECITISTEQVATCSNPQPGGPGDRCERLCECRGTLSSIAQWIAEVRKPSHHGKAQSLRDTGQQLLPSQLELIEKDVHSREVCTAEVSNSRLRFGIPGPIADEMKCQHTVGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHF8</accession>
    <name>A0A074ZHF8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169627.1">
        <property type="nucleotide sequence ID" value="XM_009171363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHF8"/>
    <dbReference type="GeneID" id="20328129"/>
    <dbReference type="KEGG" id="ovi:T265_13962"/>
    <dbReference type="CTD" id="20328129"/>
    <dbReference type="OrthoDB" id="6267648at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836485" evidence="2">
        <location>
            <begin position="16"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="541" mass="63711" checksum="EC1DA85A56C0ED41" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHK7</accession>
    <name>A0A074ZHK7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactate/malate dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596883">
        <property type="protein sequence ID" value="KER22725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173533.1">
        <property type="nucleotide sequence ID" value="XM_009175269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHK7"/>
    <dbReference type="STRING" id="6198.A0A074ZHK7"/>
    <dbReference type="GeneID" id="20323423"/>
    <dbReference type="KEGG" id="ovi:T265_09244"/>
    <dbReference type="CTD" id="20323423"/>
    <dbReference type="OrthoDB" id="6273706at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19264" checksum="5F12A5B321349F3B" modified="2014-10-01" version="1">MLSEDTFWENKEKRPVGLQRSPISLVVPIWSSVTCAGLKLRSVYPEIGTADDKEGYNKIPQDLIEKYFKLFYDVLNSEHAIKKGKGANAWAVGLATSVICQALLTDSNSIFPLSIHAKGLQGVDKDIFFSLPCIVNTNGVRGIMLQQLDDDEKEKLFVSAKKMEELLQSIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHT9</accession>
    <name>A0A074ZHT9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169396.1">
        <property type="nucleotide sequence ID" value="XM_009171132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHT9"/>
    <dbReference type="GeneID" id="20320162"/>
    <dbReference type="KEGG" id="ovi:T265_05980"/>
    <dbReference type="CTD" id="20320162"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15369" checksum="CAA8A9F9F2F1448A" modified="2014-10-01" version="1">MRQAPGAEVGKNTLPVTTEVCHGLLVCAKNVYDNFLHVKSGLSETHRSNRVDRLAEHLNGFDFSLESLARGETLVYKIHLVYLRSTDIFLQQITFVQNHDHLVACNFADYETLCSLCLETFGNIDNQKHDINYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI27</accession>
    <name>A0A074ZI27_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173276.1">
        <property type="nucleotide sequence ID" value="XM_009175012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI27"/>
    <dbReference type="GeneID" id="20323222"/>
    <dbReference type="KEGG" id="ovi:T265_09043"/>
    <dbReference type="CTD" id="20323222"/>
    <dbReference type="OrthoDB" id="6249416at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="31516" checksum="D4F6B4048B13EF18" modified="2014-10-01" version="1">METSSLARPPGLIQLPSSLFSSMFRDLEALDFASLLPKKGWTKKRFLELFDETCQLILFQLKQKWKEKDIKIESLRARSAQIAALPPSYDKMSYFDFINGHEVVMNDASEAKKRSRMEWEESVRTRTGKRPRAVALNASTRTTNRLALDEEPIMTALPSIQQGRSPVQTTTQTTTTKRATRNQRLERTPAVSSTPINPEVNGFVVPSAARTTRSRRVGGTRLPRRPIKPQDTLTSIRGSPVMNPFQLGSSSDKQRPNQDEIQLLRQMLLQLKNYLGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI46</accession>
    <name>A0A074ZI46_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor DP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596776">
        <property type="protein sequence ID" value="KER25467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170792.1">
        <property type="nucleotide sequence ID" value="XM_009172528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI46"/>
    <dbReference type="STRING" id="6198.A0A074ZI46"/>
    <dbReference type="GeneID" id="20321269"/>
    <dbReference type="KEGG" id="ovi:T265_07090"/>
    <dbReference type="CTD" id="20321269"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="359" mass="39486" checksum="5A69E35F4B49B05D" modified="2014-10-01" version="1">MHMLQRSMKVISSTGSPIVTGELSGAPSVPRLLTIRTPAQLASSGTILGGIPSASTVRPGTLILSSAAGATPITHGVVSSGAHQPSEDIENTMVTSGDGIHAPQSGIVATQGGYYDLSTGLPASGPLSTYFQPPSPPGHDSGNEQEQMSTGFKTNGLRRYARCVCNKVKEKGVTSYIEVADELVHEYAAEHPMIPSEQLHYIQKNIRRQSGPRTEKIPLQFLVISTQRKTVIDCNIPTDKLKYLFNFDQAFEIRDEVDTLKRTGLMLRLGSIHCTQEEYNQCLELVPPSLWFYVEAIYERRQAIAPDFEALHQQRRLFVEVRLAAAEANSSSGQHAEHDDEMVEFLALRILYSVCTERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIE5</accession>
    <name>A0A074ZIE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173148.1">
        <property type="nucleotide sequence ID" value="XM_009174884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIE5"/>
    <dbReference type="GeneID" id="20323120"/>
    <dbReference type="KEGG" id="ovi:T265_08941"/>
    <dbReference type="CTD" id="20323120"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9157" checksum="2FA4358757F8DCD4" modified="2014-10-01" version="1">MSTSASFSPTTACSLSFSKSHANRSLPDPHDLLMRSILSARRASFSLRKRANSASLACFCSSLRARRASRFMDRTERPSCVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIM3</accession>
    <name>A0A074ZIM3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium:neurotransmitter symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173084.1">
        <property type="nucleotide sequence ID" value="XM_009174820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIM3"/>
    <dbReference type="STRING" id="6198.A0A074ZIM3"/>
    <dbReference type="GeneID" id="20323071"/>
    <dbReference type="KEGG" id="ovi:T265_08892"/>
    <dbReference type="CTD" id="20323071"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="89991" checksum="6800067F2B9BD180" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ15</accession>
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        <recommendedName>
            <fullName evidence="5">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">T265_05643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168966.1">
        <property type="nucleotide sequence ID" value="XM_009170702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ15"/>
    <dbReference type="GeneID" id="20319825"/>
    <dbReference type="KEGG" id="ovi:T265_05643"/>
    <dbReference type="CTD" id="20319825"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="859"/>
        </location>
    </feature>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="412"/>
        </location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="101502" checksum="9480194618A2887B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ79</accession>
    <name>A0A074ZJ79_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009172164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ79"/>
    <dbReference type="STRING" id="6198.A0A074ZJ79"/>
    <dbReference type="GeneID" id="20320978"/>
    <dbReference type="KEGG" id="ovi:T265_06799"/>
    <dbReference type="CTD" id="20320978"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="244"/>
        </location>
    </feature>
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            <begin position="265"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41214" checksum="E7A1F59ABD80EAE2" modified="2014-10-01" version="1">MRMGYADMDQWESKQERKAALMQKITGSFGKVRGCFGDRRMILFIVFVALFLDNMLLTIVVPIIPDFLIDQRVKNKSAVIAKVLSDINDSCLEFLHEPEPESTLRRVPIYASRGHSPHQHLSVYLEQLFEKEIFHRDAYFNIYGLSSQNDGPNGERNATRPGRISEQVEYCKESVNQSIHRLRRETAGNEHIQIGVMFASKSVVQLMVNPLVGPLTNRIGYSIPMFTGFLIMFVSTVVLQLLALKPAVRPEAERGSSLWNLLRDPYILVAAGPIVSGSMVQTVGFSWMLWFISIVCALYSPLTLLLRNPPRRDEARALVDRNADKPPGSINNSAIGDPMNTANFTNLSLGATLGYDPTAGGQRSYGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKC6</accession>
    <name>A0A074ZKC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_06480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170018.1">
        <property type="nucleotide sequence ID" value="XM_009171754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKC6"/>
    <dbReference type="STRING" id="6198.A0A074ZKC6"/>
    <dbReference type="GeneID" id="20320659"/>
    <dbReference type="KEGG" id="ovi:T265_06480"/>
    <dbReference type="CTD" id="20320659"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER26197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="18395" checksum="A96C6778C7E2C5B7" modified="2014-10-01" version="1">MTHPVKEFVRRISTLDIEQYPEWNLNAPLPRLPVPKLKNTLDRYLRLVAPVVAPDAYERTRKIVEEFGRPGGEGERLQKLLEEFAEKQLNWVTDWWLDDMYLMNPLPLPINSSPGMVFPRHSFISSRQQLRFAAQLISGILDYKTILDTLQSFFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKI7</accession>
    <name>A0A074ZKI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170003.1">
        <property type="nucleotide sequence ID" value="XM_009171739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKI7"/>
    <dbReference type="STRING" id="6198.A0A074ZKI7"/>
    <dbReference type="GeneID" id="20320650"/>
    <dbReference type="KEGG" id="ovi:T265_06471"/>
    <dbReference type="CTD" id="20320650"/>
    <dbReference type="OrthoDB" id="1868004at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55121" checksum="AA411C16F05DD159" modified="2014-10-01" version="1">MSTGVSETAPLNVNPNIPPFALPQTLMASSSLLQTSVSKLAQESLKEVKRLRVLVTRLLVAVDSTTDDTSEEDAYQGPDVDSEGRRGGTTRLGLVPSPTVTTSDNKFPYSVSRPTSFGRTKELTEPMHLHKTVLQISDALDALDQLASLMHTARMNTRMGELGLHQALSFLTTVDQLEFGGISSSTELGDSTDPIVSVEQEPRRTSWLLDRSDAERWSNRYWERTHTILGGLLTCSVFRRSHLNSDLKRHRLDATTSRDVRADLEHLLNDIHAACPKLTITLVDGGFNLNVAHVRVADILQCFVTFRRLHPERIIVRGLTEPMVIKLAAATGPNVTDSEQEMSSNSIEELLSKCDLSGATKETLLSLIGPDRSPKTASDARGRRSGGAASYGRPVLTTQIGIQQLDLVTPSRFALFQRITTLAQCAILHFSNDYQPPSAVRGLFHWLHSYHDLFTTPCGRCGQLLGQDVSLPVWRSYPQLRKDDSRSIVPQHEHCQAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLM2</accession>
    <name>A0A074ZLM2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596817">
        <property type="protein sequence ID" value="KER24255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172005.1">
        <property type="nucleotide sequence ID" value="XM_009173741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLM2"/>
    <dbReference type="STRING" id="6198.A0A074ZLM2"/>
    <dbReference type="GeneID" id="20322226"/>
    <dbReference type="KEGG" id="ovi:T265_08047"/>
    <dbReference type="CTD" id="20322226"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10742" checksum="CB751685A1F25265" modified="2014-10-01" version="1">MALENILKYGVVMDPMAWLQFILQTPDKYHDLGLSLCCNLFIIAARFLEYAVLQRMLHYNIALGLGCTKLFCALIFPTLIILMHDFNPLFSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMF0</accession>
    <name>A0A074ZMF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169327.1">
        <property type="nucleotide sequence ID" value="XM_009171063.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZMF0"/>
    <dbReference type="GeneID" id="20320110"/>
    <dbReference type="KEGG" id="ovi:T265_05928"/>
    <dbReference type="CTD" id="20320110"/>
    <dbReference type="OrthoDB" id="7668649at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1574"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1949"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1972" mass="207566" checksum="FB2AA6C97570B7DD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
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        <name type="scientific">Opisthorchis viverrini</name>
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                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000054324"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX1</accession>
    <name>A0A074ZPX1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZPX1"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
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        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP synthase D chain-like"/>
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    </dbReference>
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    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER25375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="20285" checksum="ED2FFECF55E28620" modified="2014-10-01" version="1">MAAKRISRSAINWLELHNQCPKHQLDQFRDFKTRTDGLVSRISGLPESLPQINWDAYAHTVPVPGLVDKFRKEYENLQVEYPKDSANVLDKVKAQGQQMMDNAKRHIAVCEKMKTSANKMKNTVDNLPKIDELIPELTIAYFPLTNLDPFRTGERKPEEEKNLLKNVAPKAHWDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQK4</accession>
    <name>A0A074ZQK4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SCAI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168166.1">
        <property type="nucleotide sequence ID" value="XM_009169902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQK4"/>
    <dbReference type="STRING" id="6198.A0A074ZQK4"/>
    <dbReference type="GeneID" id="20319194"/>
    <dbReference type="KEGG" id="ovi:T265_05012"/>
    <dbReference type="CTD" id="20319194"/>
    <dbReference type="OrthoDB" id="525027at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62816" checksum="055D5FBBD63542A7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQS0</accession>
    <name>A0A074ZQS0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166756.1">
        <property type="nucleotide sequence ID" value="XM_009168492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQS0"/>
    <dbReference type="GeneID" id="20327519"/>
    <dbReference type="KEGG" id="ovi:T265_13352"/>
    <dbReference type="CTD" id="20327519"/>
    <dbReference type="OrthoDB" id="10614152at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="128" mass="13649" checksum="713662F6E56BB65B" modified="2014-10-01" version="1" fragment="single">NIRTSLRIRLALTRSELTSPDSTEELFNSIDELVQLLDDVSFDSSQPIKPAKNTVRSPPGSILAVLNRLLISWRFVGVSDSGARASFAAAQSIFGVPLLAASRTAFARPPRGSLAPPTYSVGEGAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRL9</accession>
    <name>A0A074ZRL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166552.1">
        <property type="nucleotide sequence ID" value="XM_009168288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRL9"/>
    <dbReference type="GeneID" id="20317928"/>
    <dbReference type="KEGG" id="ovi:T265_03741"/>
    <dbReference type="CTD" id="20317928"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8005" checksum="C49A738BEDE04493" modified="2014-10-01" version="1">MSVAVDEDKRGESATSKVPIAAVFRSSTMGDAARCGNAFSCAMRTRTAYRSIKCDRPGAETRVANIHHSQQGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS25</accession>
    <name>A0A074ZS25_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_03347</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rabaptin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166072.1">
        <property type="nucleotide sequence ID" value="XM_009167808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS25"/>
    <dbReference type="STRING" id="6198.A0A074ZS25"/>
    <dbReference type="GeneID" id="20317534"/>
    <dbReference type="KEGG" id="ovi:T265_03347"/>
    <dbReference type="CTD" id="20317534"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018514">
        <property type="entry name" value="Rabaptin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03528">
        <property type="entry name" value="Rabaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rabaptin coiled-coil" evidence="13">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Rabaptin GTPase-Rab5 binding" evidence="14">
        <location>
            <begin position="367"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="535"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="665" mass="75313" checksum="A206D0CE4B663D1D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSE9</accession>
    <name>A0A074ZSE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596723">
        <property type="protein sequence ID" value="KER27440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168848.1">
        <property type="nucleotide sequence ID" value="XM_009170584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVM9"/>
    <dbReference type="GeneID" id="20327971"/>
    <dbReference type="KEGG" id="ovi:T265_13804"/>
    <dbReference type="CTD" id="20327971"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11540" checksum="A50335BC0CCDCDC6" modified="2014-10-01" version="1" fragment="single">WLLTCSPSLAIDPQTFRHHTRRHHLCAFDDASSYGDETFMTPSLAVGLQTFRPRSSRHRQSAVDPSNCKPIAKLGKQINCHLFNHQNIQITNNLVYQINKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW20</accession>
    <name>A0A074ZW20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166195.1">
        <property type="nucleotide sequence ID" value="XM_009167931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW20"/>
    <dbReference type="GeneID" id="20317634"/>
    <dbReference type="KEGG" id="ovi:T265_03447"/>
    <dbReference type="CTD" id="20317634"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER30082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="16143" checksum="6AC55ECDB8AC5856" modified="2014-10-01" version="1">MVHVPYVNELLNAFAAPVKYLLSSTKVTAQEPTLVIVRDSFSLSMLVRLAGLSGALSVIAGAFGAHGFSADREKDKRIFQTGAYYNLVHSIALLGATQARRPNLTAGLFLLGMSMFCGSCYYVALTGDNRVSKIAPVGGITLIIAWLSFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWB7</accession>
    <name>A0A074ZWB7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166155.1">
        <property type="nucleotide sequence ID" value="XM_009167891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWB7"/>
    <dbReference type="GeneID" id="20327408"/>
    <dbReference type="KEGG" id="ovi:T265_13241"/>
    <dbReference type="CTD" id="20327408"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="261"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="543" mass="62336" checksum="24C7D1F4DD6AECCD" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWV9</accession>
    <name>A0A074ZWV9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168398.1">
        <property type="nucleotide sequence ID" value="XM_009170134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWV9"/>
    <dbReference type="GeneID" id="20319372"/>
    <dbReference type="KEGG" id="ovi:T265_05190"/>
    <dbReference type="CTD" id="20319372"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19721" checksum="B9BC0058305C1360" modified="2014-10-01" version="1">MYGFCRTITYRGACCFPCLNIINGSKVDRDRIILNAAGCRRSKIWLLIEAYGGCVADFNPGCLNECPERITHLVPQNQNIRWAWESEYQLFWRSKCNERFCRYQTWPSATGGEPQFKTAVPSGAHHLIAITPWCAHANLAAANYKSTVDPVGPRGHQPPVESHNSRLPFLLGHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXM0</accession>
    <name>A0A074ZXM0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_02911</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009167275.1"/>
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    <dbReference type="KEGG" id="ovi:T265_02911"/>
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    <dbReference type="OrthoDB" id="1405469at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of mitochondrial fission"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
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        </source>
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    <sequence length="624" mass="67957" checksum="5F625637D11C1E4C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Wongkham S."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
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                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
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                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
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</entry>
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    <accession>A0A074ZZ59</accession>
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        </submittedName>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
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                <person name="Maleewong W."/>
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                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER28595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="598" mass="67498" checksum="5864ECE0EE8F4635" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0A3</accession>
    <name>A0A075A0A3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163539.1">
        <property type="nucleotide sequence ID" value="XM_009165275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0A3"/>
    <dbReference type="STRING" id="6198.A0A075A0A3"/>
    <dbReference type="GeneID" id="20326920"/>
    <dbReference type="KEGG" id="ovi:T265_12752"/>
    <dbReference type="CTD" id="20326920"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="330" mass="37673" checksum="3D15FA5224E640EB" modified="2014-10-01" version="1" fragment="single">MTAVGCKLTKLQQRLQSAIEERRFYEAHQIYKTVYFRCITRRNYVEALKYLYSGADFLLTNKQWESGIELASMILEVYTKSKMELTEVHLNQMCDLLRKMNPSEDRSNFIQKATGLLNNHKSLLCGFNEQLARIFWQEGSFTEARFRIMLSFNGHAVGSFLIALHQRYGLRSEIDLFITQAVLQFLCMRQAPAAVLTFYTYTRGHPRLEPGPPFTRFPLLNFVWFLMLAIERKCTVSVFSLLCEKYSPQIRRDSTYLAYLDKIGQLYFGIKPASSGGMNNLFSNLLKMLSGADEGDIDSSSDGPDPIPSTSNELDGPSSAIDNMCVDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0F1</accession>
    <name>A0A075A0F1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_10651</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597011">
        <property type="protein sequence ID" value="KER20904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175360.1">
        <property type="nucleotide sequence ID" value="XM_009177096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0F1"/>
    <dbReference type="STRING" id="6198.A0A075A0F1"/>
    <dbReference type="GeneID" id="20324819"/>
    <dbReference type="KEGG" id="ovi:T265_10651"/>
    <dbReference type="CTD" id="20324819"/>
    <dbReference type="OrthoDB" id="8020218at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="15">
        <location>
            <begin position="462"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="484"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER20904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="705" mass="77728" checksum="ADC57DE3249D9AB8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0K8</accession>
    <name>A0A075A0K8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164479.1">
        <property type="nucleotide sequence ID" value="XM_009166215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0K8"/>
    <dbReference type="GeneID" id="20327075"/>
    <dbReference type="KEGG" id="ovi:T265_12907"/>
    <dbReference type="CTD" id="20327075"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="262" mass="30411" checksum="44DC78BAD8836A36" modified="2014-10-01" version="1" fragment="single">ETTHKVAENSSTAHDRFRPSWGSSDRRRPRVSVNLMFYLNPNWTVFEKYTHWQINLVFTGNSIESLMRRHRLIRIFLPFGALNNRLIPLHEADNHLRMTALFWGPWSEWQPCPDPKLLCVPFGISLHQGTAVRRARMCERQEFKRNSTTNTFYRINVDNELVPCSKERSTEQQIKHCPLPPRCSGSNGPPAVRDEQGFHAGKSDFNAYLCNVLLIRLLKIRRQPTTGFALFGAHQKKSTESLVYDILRLNMLHKDCLMLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1M0</accession>
    <name>A0A075A1M0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162576.1">
        <property type="nucleotide sequence ID" value="XM_009164312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1M0"/>
    <dbReference type="GeneID" id="20314696"/>
    <dbReference type="KEGG" id="ovi:T265_00508"/>
    <dbReference type="CTD" id="20314696"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9234" checksum="77C1159216DA8CF4" modified="2014-10-01" version="1">MSDVLERKLLTRLLKTLRQPTTSFALLFRAHQVGVVPEFTSTLCSAWTQIGLIATNTFICKSTWFSRVTQVNPYFMLFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1P5</accession>
    <name>A0A075A1P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162596.1">
        <property type="nucleotide sequence ID" value="XM_009164332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1P5"/>
    <dbReference type="GeneID" id="20314716"/>
    <dbReference type="KEGG" id="ovi:T265_00528"/>
    <dbReference type="CTD" id="20314716"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7948" checksum="8CCEBB5B05FA4345" modified="2014-10-01" version="1">MKRNANSLKHQMGNELYSSEVVFFDVDAPTTKGNKQFVPGIADLVPLTKQQEHLDHFYRDIFLKRGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A213</accession>
    <name>A0A075A213_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164061.1">
        <property type="nucleotide sequence ID" value="XM_009165797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A213"/>
    <dbReference type="STRING" id="6198.A0A075A213"/>
    <dbReference type="GeneID" id="20327004"/>
    <dbReference type="KEGG" id="ovi:T265_12836"/>
    <dbReference type="CTD" id="20327004"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="14714" checksum="C5304CBA803D4B25" modified="2014-10-01" version="1" fragment="single">MINNQPVCRCKSITDLCSDVKVRTPDNGEQNVDSVVLALRHSELTAEQVRACSPDGCPPTHSGPRCLQENLPEPSSAVPMILVTPSQDATTGEEDFILDQSHIGANIRMKSAPEGTDKCHLPEFQHSSGKFCASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A298</accession>
    <name>A0A075A298_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163922.1">
        <property type="nucleotide sequence ID" value="XM_009165658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A298"/>
    <dbReference type="GeneID" id="20315787"/>
    <dbReference type="KEGG" id="ovi:T265_01599"/>
    <dbReference type="CTD" id="20315787"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9148" checksum="3FE7D7A761AA3C85" modified="2014-10-01" version="1">MSTEEKIQSADLRIANTLHLSDRRSYCGLSYGNLSAKITFSTMSKSSKLDLKSKFEPPTEFRQQSEPKPCQPEASLGHNTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3A7</accession>
    <name>A0A075A3A7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161940.1">
        <property type="nucleotide sequence ID" value="XM_009163676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3A7"/>
    <dbReference type="STRING" id="6198.A0A075A3A7"/>
    <dbReference type="GeneID" id="20314207"/>
    <dbReference type="KEGG" id="ovi:T265_00019"/>
    <dbReference type="CTD" id="20314207"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="141"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="809" mass="88322" checksum="BB55DE7886431CAF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3G7</accession>
    <name>A0A075A3G7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163524.1">
        <property type="nucleotide sequence ID" value="XM_009165260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3G7"/>
    <dbReference type="GeneID" id="20315463"/>
    <dbReference type="KEGG" id="ovi:T265_01275"/>
    <dbReference type="CTD" id="20315463"/>
    <dbReference type="OrthoDB" id="6249169at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="645" mass="71292" checksum="63C54D0C90535BAF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3Q3</accession>
    <name>A0A075A3Q3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162068.1">
        <property type="nucleotide sequence ID" value="XM_009163804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3Q3"/>
    <dbReference type="STRING" id="6198.A0A075A3Q3"/>
    <dbReference type="GeneID" id="20314335"/>
    <dbReference type="KEGG" id="ovi:T265_00147"/>
    <dbReference type="CTD" id="20314335"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="26828" checksum="5AB7238B20289031" modified="2014-10-01" version="1">MPRPGFSVVEMCLPFHCDCSHYLFGLLLCCMHSKHHTSHSLLIDCGGSFLVSKFVAYIENRIPNPTTSSGLGSKGLLEELLSRLHVIRVFTHRELTLALYASRDVLSRRPISFIFFNNINAFGDLENLTAHPKKKATAEQILWCGMLQRLLRDFNLLCISIRRCVPRLNCRQQSKGCDSVQSNFPVSASFPFYQESMSSNWVNCLTHRIEIISCQSQYVSYVKRDSTFQVAIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4R0</accession>
    <name>A0A075A4R0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162903.1">
        <property type="nucleotide sequence ID" value="XM_009164639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4R0"/>
    <dbReference type="STRING" id="6198.A0A075A4R0"/>
    <dbReference type="GeneID" id="20314955"/>
    <dbReference type="KEGG" id="ovi:T265_00767"/>
    <dbReference type="CTD" id="20314955"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="15867" checksum="1A99060BEF35FF3C" modified="2014-10-01" version="1">MADQPVYAPFFGLMGCSLAIILCSLGAGYGTAKAGSSIACMSINRPDLVMKSLIPVVMAGIIAIYGLVVSVLISQRIDDRYTLDASFYDLGSGLSVGISGVAAGYAIGVVGDEGVRSTSKQPRVFVGMVLILIFAEVLGLYGLIVALMFSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Z8</accession>
    <name>A0A075A4Z8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone deacetylase 3</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_09425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KL596895">
        <property type="protein sequence ID" value="KER22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173743.1">
        <property type="nucleotide sequence ID" value="XM_009175479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Z8"/>
    <dbReference type="STRING" id="6198.A0A075A4Z8"/>
    <dbReference type="GeneID" id="20323594"/>
    <dbReference type="KEGG" id="ovi:T265_09425"/>
    <dbReference type="CTD" id="20323594"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="148"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="63373" checksum="B0035DB2E4228FA4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6J0</accession>
    <name>A0A075A6J0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164956.1">
        <property type="nucleotide sequence ID" value="XM_009166692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6J0"/>
    <dbReference type="GeneID" id="20316631"/>
    <dbReference type="KEGG" id="ovi:T265_02443"/>
    <dbReference type="CTD" id="20316631"/>
    <dbReference type="OrthoDB" id="6272694at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="351" mass="38907" checksum="EDF51670D8D26C81" modified="2014-10-01" version="1">MFCFGNVDYNQGNGTTYLLYAVSGSILKQSVWTILLLSSSCFSLERYLIATLCNNIPQCEMPPMRFPAFLSSNFPPLPFSLSSGFDWDMYWLCRAIICRKQRWRTLDLTEGYGLYTARLNEWRCRHFEVIVHACKDQQLKQGQTMINALQGPSRRDWTLPWCDGPALRTDDSVRHASVLRSGSVRHMVPAFSGISKSVLKPRHPVYLAAFNVRTLKQAGQQAALALTLDSLGIDVCCLSNENSRCKHISNRFRLRTSGDPEAAAVGCAGVGIVLSHWAEVSLLDWIPVDSRLCANANQSESSTLTRRFSPPHGHSGTTLCPAPEAALVGTCVTYASFAEESTVFHAQFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6J6</accession>
    <name>A0A075A6J6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596866">
        <property type="protein sequence ID" value="KER23064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173174.1">
        <property type="nucleotide sequence ID" value="XM_009174910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6J6"/>
    <dbReference type="STRING" id="6198.A0A075A6J6"/>
    <dbReference type="GeneID" id="20323142"/>
    <dbReference type="KEGG" id="ovi:T265_08963"/>
    <dbReference type="CTD" id="20323142"/>
    <dbReference type="OrthoDB" id="69656at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123797" checksum="B728BC2111FC91FF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9D3</accession>
    <name>A0A075A9D3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172143.1">
        <property type="nucleotide sequence ID" value="XM_009173879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9D3"/>
    <dbReference type="GeneID" id="20322338"/>
    <dbReference type="KEGG" id="ovi:T265_08159"/>
    <dbReference type="CTD" id="20322338"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7513" checksum="C32E0706AA90BC71" modified="2014-10-01" version="1">MDETTGRVRRWSRGTNQRGQVRKSPGRRPTRTRSPTHLPKQPKCEAQRIAQSATISLNNQTAKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC56</accession>
    <name>A0A075AC56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170951.1">
        <property type="nucleotide sequence ID" value="XM_009172687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC56"/>
    <dbReference type="GeneID" id="20321401"/>
    <dbReference type="KEGG" id="ovi:T265_07222"/>
    <dbReference type="CTD" id="20321401"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19028" checksum="C75812C5AC894887" modified="2014-10-01" version="1">MTSDWIALPKALLPSVGRFCGTDNPVILPPVSNATPTCRPTQTAFETSGIWRHPSEHRTTIRFLAAAGVMVMLMLPLKRANESGVMVMLLPLKRANESGVMVVLLPRTNEPMRVECGDSNWMTATVSTVVGSGVAYAFRMFPLRDIEIHQCDVEYTDNRLGSGIVFLAPVLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACT2</accession>
    <name>A0A075ACT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="11" type="ORF">T265_12552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162540.1">
        <property type="nucleotide sequence ID" value="XM_009164276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACT2"/>
    <dbReference type="GeneID" id="20326720"/>
    <dbReference type="KEGG" id="ovi:T265_12552"/>
    <dbReference type="CTD" id="20326720"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="884" mass="100066" checksum="AB585E5A867415A6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD37</accession>
    <name>A0A075AD37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170427.1">
        <property type="nucleotide sequence ID" value="XM_009172163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD37"/>
    <dbReference type="GeneID" id="20320977"/>
    <dbReference type="KEGG" id="ovi:T265_06798"/>
    <dbReference type="CTD" id="20320977"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="425" mass="47703" checksum="AA11489232413A16" modified="2014-10-01" version="1">MDWKRAPPKPLSVANLSKAIVGSAPGDKMNSNGVVQLESWYVRAKSNGGGSMNLRPNFSRTEEKEDQKPSKTTDRLEPKATEPPNTYNDPRHVAFLSQSTESTLNLFFALKNTIAFFSARIRRLLAVVTISSCLASSSSGLFTVTKKTNEREISTSFWLIDESQRVYTAFGDVRPMFVGCDVTKFSDKTPVSTKPSFESVSMDNDRVVDSRESAAISCYYSGKMIALEVHGDVDTAGGIRVASTRDPSYSTPLVSNKASILSKRTAVEEDWIVPDYIHRHSFEHQPEELELVYQFKHLGSKISRECNVTEVNIRLVEGLVPKKTSRQGTQQLCYKQTLRDELNRGDRQQVSNKAGLCPFDDRVQYPRWEKVEYRLIESHTSRCSKNLSLTGFKVKFYAGLGCFYQTEYSGRNKVRPLAPVSNGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADG6</accession>
    <name>A0A075ADG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161971.1">
        <property type="nucleotide sequence ID" value="XM_009163707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADG6"/>
    <dbReference type="STRING" id="6198.A0A075ADG6"/>
    <dbReference type="GeneID" id="20314238"/>
    <dbReference type="KEGG" id="ovi:T265_00050"/>
    <dbReference type="CTD" id="20314238"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="551" mass="62529" checksum="0F6A01C770A6B83A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF63</accession>
    <name>A0A075AF63_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168880.1">
        <property type="nucleotide sequence ID" value="XM_009170616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF63"/>
    <dbReference type="GeneID" id="20319757"/>
    <dbReference type="KEGG" id="ovi:T265_05575"/>
    <dbReference type="CTD" id="20319757"/>
    <dbReference type="OrthoDB" id="6235225at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12645" checksum="7A3AB09201062902" modified="2014-10-01" version="1">MGSASGKVYVQFDNFCEDKTYEDIALEKFGCDLKGTVLCPENETSITCLNGGACALYLKDLEDVCEQKCRCTPDYIGKYCHLYNGFLNATVGLMVGILLAIILTVFIVIIVWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH74</accession>
    <name>A0A075AH74_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin interacting protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166874.1">
        <property type="nucleotide sequence ID" value="XM_009168610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20327543"/>
    <dbReference type="KEGG" id="ovi:T265_13376"/>
    <dbReference type="CTD" id="20327543"/>
    <dbReference type="OrthoDB" id="6022652at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="2">
        <location>
            <begin position="626"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1303" mass="141452" checksum="1783D681B13E1C80" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHK7</accession>
    <name>A0A075AHK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166175.1">
        <property type="nucleotide sequence ID" value="XM_009167911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHK7"/>
    <dbReference type="GeneID" id="20317614"/>
    <dbReference type="KEGG" id="ovi:T265_03427"/>
    <dbReference type="CTD" id="20317614"/>
    <dbReference type="OrthoDB" id="10453769at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="7937" checksum="D7650F6BA493834C" modified="2014-10-01" version="1">MGERITCNPAESLGFDVSRQLNVLHQADACFSRYDIRHIAIHATECAAPGRLMFQSLRYLKYRDTCIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHP9</accession>
    <name>A0A075AHP9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_03314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166024.1">
        <property type="nucleotide sequence ID" value="XM_009167760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHP9"/>
    <dbReference type="STRING" id="6198.A0A075AHP9"/>
    <dbReference type="GeneID" id="20317501"/>
    <dbReference type="KEGG" id="ovi:T265_03314"/>
    <dbReference type="CTD" id="20317501"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="324"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="796" mass="88883" checksum="BEA1B63C0DB3505C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHY6</accession>
    <name>A0A075AHY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Misato Segment II tubulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165564.1">
        <property type="nucleotide sequence ID" value="XM_009167300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHY6"/>
    <dbReference type="STRING" id="6198.A0A075AHY6"/>
    <dbReference type="GeneID" id="20317124"/>
    <dbReference type="KEGG" id="ovi:T265_02936"/>
    <dbReference type="CTD" id="20317124"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="514" mass="57123" checksum="CCC79782BC94387E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AID3</accession>
    <name>A0A075AID3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164821.1">
        <property type="nucleotide sequence ID" value="XM_009166557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AID3"/>
    <dbReference type="STRING" id="6198.A0A075AID3"/>
    <dbReference type="GeneID" id="20316531"/>
    <dbReference type="KEGG" id="ovi:T265_02343"/>
    <dbReference type="CTD" id="20316531"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="648" mass="73188" checksum="EAE069730F55FBC0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ31</accession>
    <name>A0A075AJ31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163626.1">
        <property type="nucleotide sequence ID" value="XM_009165362.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJ31"/>
    <dbReference type="GeneID" id="20315544"/>
    <dbReference type="KEGG" id="ovi:T265_01356"/>
    <dbReference type="CTD" id="20315544"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF419">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="661"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1389" mass="152996" checksum="C8C10D86D8F7AC35" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ53</accession>
    <name>A0A075AJ53_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163543.1">
        <property type="nucleotide sequence ID" value="XM_009165279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ53"/>
    <dbReference type="GeneID" id="20326924"/>
    <dbReference type="KEGG" id="ovi:T265_12756"/>
    <dbReference type="CTD" id="20326924"/>
    <dbReference type="OrthoDB" id="10476393at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="19986" checksum="A15BFABE387CF8F6" modified="2014-10-01" version="1" fragment="single">LVNLVFTSDSTESLVYDILQLNVLHTGRCRIFEISQHVFIKETTHKVAEKSPTTHDRFCSSWGSSGRRSPQVFVKFMIYLMSPKKGETGRGSNLRKLVADQMAVDLFAELGNWLANVSSPVEETSSVRSCWCAFNCALTMSPRQPERTFASQLLSSANRSTGIRSATSKHTRATYISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ65</accession>
    <name>A0A075AJ65_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163358.1">
        <property type="nucleotide sequence ID" value="XM_009165094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ65"/>
    <dbReference type="GeneID" id="20315321"/>
    <dbReference type="KEGG" id="ovi:T265_01133"/>
    <dbReference type="CTD" id="20315321"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13410" checksum="3A57E40C505AD43D" modified="2014-10-01" version="1">MGDQGGRLSFEGFVVRPPVDPLPCRNRHKQEVLTRHCHANNGILRLPSFRKHLVTHRSRSIGLSDTEKCSADKGEILALGFRCLAVRVSSDFQEQPENLRNVRHAKRNAIEVKSDTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJA9</accession>
    <name>A0A075AJA9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163145.1">
        <property type="nucleotide sequence ID" value="XM_009164881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20315154"/>
    <dbReference type="KEGG" id="ovi:T265_00966"/>
    <dbReference type="CTD" id="20315154"/>
    <dbReference type="OrthoDB" id="6228672at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1482" mass="161327" checksum="DE43807EF5912DB5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJS3</accession>
    <name>A0A075AJS3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162336.1">
        <property type="nucleotide sequence ID" value="XM_009164072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJS3"/>
    <dbReference type="STRING" id="6198.A0A075AJS3"/>
    <dbReference type="GeneID" id="20314515"/>
    <dbReference type="KEGG" id="ovi:T265_00327"/>
    <dbReference type="CTD" id="20314515"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="20465" checksum="A164A9FC08341C32" modified="2014-10-01" version="1">MEHLTSKGMEVKVISMDDYYWRVDDPRHVRNPETGFPNFDCYSAVDWESLIEDVHQWSSHKPAGVRSSNPNRFLFVEGIFVLECETLFQTFDVSIFLKLNYETMLERRLLRDYDPPDPPNYFKDYVWPAYCKSLESVSSRAGRTIFVECRGLSFEDMFRRVLGCIHDKLVIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJY9</accession>
    <name>A0A075AJY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The WWE domain mediates non-covalent poly(ADP-ribose)-binding.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Ubiquitinated; autoubiquitinated.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161995.1">
        <property type="nucleotide sequence ID" value="XM_009163731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJY9"/>
    <dbReference type="STRING" id="6198.A0A075AJY9"/>
    <dbReference type="GeneID" id="20314262"/>
    <dbReference type="KEGG" id="ovi:T265_00074"/>
    <dbReference type="CTD" id="20314262"/>
    <dbReference type="OrthoDB" id="10065815at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033509">
        <property type="entry name" value="RNF146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13417:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="3">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="32669" checksum="C26C8161759FED48" modified="2014-10-01" version="1">MQNKISAVAQFSWSSISLVDTARGENNIVAPDRSTVPCSEPAASTSSYPTTTNGLPPTVYGWFYEGYAGWWEYDERTSAELEDAFSKGHAKCEIVAAGHIYVVDFCTMSQGRKDHTGRKRRIKRDLITCEKKGIAGIKLTSIQPGKTSVTTTVTSASTGTSVSVTASPKTSATRVTAQSSQPVTLTDHTYARPTSSVPIHTHDTRYRAISCSSSPNPQLVPNVQMLPSLPTVCPPPNVSRTSSRRQSRPSVRLPAVTPTSGPVDSSTTLLPTTLIDGSVVGVQPVVHASISPRHHRSTRSLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVN6</accession>
    <name>A0A074YVN6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_12179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598337">
        <property type="protein sequence ID" value="KER18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177530.1">
        <property type="nucleotide sequence ID" value="XM_009179266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVN6"/>
    <dbReference type="GeneID" id="20326347"/>
    <dbReference type="KEGG" id="ovi:T265_12179"/>
    <dbReference type="CTD" id="20326347"/>
    <dbReference type="OrthoDB" id="8300295at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="844" mass="97170" checksum="9104096D4AECAB85" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXL0</accession>
    <name>A0A074YXL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597220">
        <property type="protein sequence ID" value="KER19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176850.1">
        <property type="nucleotide sequence ID" value="XM_009178586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXL0"/>
    <dbReference type="STRING" id="6198.A0A074YXL0"/>
    <dbReference type="GeneID" id="20329718"/>
    <dbReference type="KEGG" id="ovi:T265_15553"/>
    <dbReference type="CTD" id="20329718"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2100:FF:000002">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="282" mass="31320" checksum="199ADBA8C2E35114" modified="2014-10-01" version="1" fragment="single">MVRLLAKTPNEGSMLQGVDLTLEIPNHITSSGTNVETLFNGSIRKTLSDWVVDILQANGGHLRLKKLRKQSKAGSNKQQQWTSVVQNVISKSAVQDPLLCQVMQELQSSENLPRKKQKFLNFMKSKYRRLRPDQVEQIWEILDSQLYSLYKASVSTSCCRISSQEFEQQLLDAISSRKTISYSEADGMVRLLAKTPNEGSMLQGVDLTLEIPNHITSSGTNVETLFNGSIRKTLSDWVVDILQANGGHLRLKKLRKQFNGVGGGGAGGLLDRLPPANDRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXQ6</accession>
    <name>A0A074YXQ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_11685</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KL597175">
        <property type="protein sequence ID" value="KER19581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176671.1">
        <property type="nucleotide sequence ID" value="XM_009178407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXQ6"/>
    <dbReference type="STRING" id="6198.A0A074YXQ6"/>
    <dbReference type="GeneID" id="20325853"/>
    <dbReference type="KEGG" id="ovi:T265_11685"/>
    <dbReference type="CTD" id="20325853"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="15">
        <location>
            <begin position="338"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER19581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="574" mass="62954" checksum="2140F8785A47DEA8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYE1</accession>
    <name>A0A074YYE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing helicase BRR2-like plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597161">
        <property type="protein sequence ID" value="KER19653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176595.1">
        <property type="nucleotide sequence ID" value="XM_009178331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYE1"/>
    <dbReference type="STRING" id="6198.A0A074YYE1"/>
    <dbReference type="GeneID" id="20325795"/>
    <dbReference type="KEGG" id="ovi:T265_11627"/>
    <dbReference type="CTD" id="20325795"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing helicase BRR2-like plug" evidence="2">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="294" mass="33188" checksum="694B2055F08C3F93" modified="2014-10-01" version="1">MADDAARRLQFEYKVNSSLVLLTDRSLIDRRPRDESTGEVLSLAGRIRVQEMGHKSQRTKPPMLQEKRAKRQKRDEIQQDALKLKSASLLNDELDDIAGVVYRPKTPDTRKTYEYILHCIQEALGDQSREILCGAADEVIATFKNSHLKDGERRKETESLLGRLADERYNIIVNLCKKITDWKDENASTATGENIDETYGVNVQFEESDQEISLNSQSAKRTTFSLDSLCESTCASVVVVWSVDMGAAGGLSLDPPMLFTGPTITYIQTSILEWCPPTYQPRIQIDHIAISCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYG9</accession>
    <name>A0A074YYG9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597128">
        <property type="protein sequence ID" value="KER19846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176406.1">
        <property type="nucleotide sequence ID" value="XM_009178142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYG9"/>
    <dbReference type="GeneID" id="20325642"/>
    <dbReference type="KEGG" id="ovi:T265_11474"/>
    <dbReference type="CTD" id="20325642"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17097" checksum="F7608A64C1821ED7" modified="2014-10-01" version="1">MKPADRTTSRDQSSAQAGSTYINTHATLLITPPPTHRSTHLRLGSSSRRIWRLTNSSKETSGTNSAGRGPVALRMAIQLSIENPFGGPSYHATERRVGILPGCPNLVRGSRETEVGFEPRTFRSVNSRSNHLSPSYDQERPDPCGILWPKCDLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYQ7</accession>
    <name>A0A074YYQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597138">
        <property type="protein sequence ID" value="KER19793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176453.1">
        <property type="nucleotide sequence ID" value="XM_009178189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYQ7"/>
    <dbReference type="GeneID" id="20325681"/>
    <dbReference type="KEGG" id="ovi:T265_11513"/>
    <dbReference type="CTD" id="20325681"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8421" checksum="D20CE68FEB915080" modified="2014-10-01" version="1">MAQGAFTIALNLAVVVIVIMHELPIFRGTINAFTAIKLFNMQYTPKILLRHNLVDDDEPGAYHQTTNELVKEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYY6</accession>
    <name>A0A074YYY6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601592">
        <property type="protein sequence ID" value="KER18417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177836.1">
        <property type="nucleotide sequence ID" value="XM_009179572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYY6"/>
    <dbReference type="GeneID" id="20330236"/>
    <dbReference type="KEGG" id="ovi:T265_16071"/>
    <dbReference type="CTD" id="20330236"/>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="52" mass="5534" checksum="9E59F7FA49310EA7" modified="2014-10-01" version="1" fragment="single">MVLPDDALRFLIARELLRLGACTADGTSLLASARSNSVFTMTGIIGILYAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Z5</accession>
    <name>A0A074Z0Z5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597317">
        <property type="protein sequence ID" value="KER19132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177121.1">
        <property type="nucleotide sequence ID" value="XM_009178857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Z5"/>
    <dbReference type="GeneID" id="20329812"/>
    <dbReference type="KEGG" id="ovi:T265_15647"/>
    <dbReference type="CTD" id="20329812"/>
    <dbReference type="OrthoDB" id="6751474at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19234" checksum="BA04830C23CAD6FE" modified="2014-10-01" version="1" fragment="single">MCAYIPRALQKLPYTKCGPSSIPTLFFLPQIRKEWAVVYKIDLPKSSQTFDVHLTHTKSEVMLVDVQSLGTPLTIQLSYRVISSEFGWRHHNIVLRSDVGDVLVVRFHPGYPSDGLEVYAPRYDCNKLVLVLFGLIGDIGLRNEAKNHVQPSFSESSETMVGRKFMAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z117</accession>
    <name>A0A074Z117_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597026">
        <property type="protein sequence ID" value="KER20726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175513.1">
        <property type="nucleotide sequence ID" value="XM_009177249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z117"/>
    <dbReference type="GeneID" id="20324948"/>
    <dbReference type="KEGG" id="ovi:T265_10780"/>
    <dbReference type="CTD" id="20324948"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="53" mass="6249" checksum="B86AD3BFFB3EDEB0" modified="2014-10-01" version="1" fragment="single">CFLWHDIRDTVQTTLSSKTCPISEELIHLPHRFQNHTHLTYHALIKETTHKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z126</accession>
    <name>A0A074Z126_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin/FtsZ 2-layer sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_11976</name>
        <name evidence="9" type="ORF">T265_11977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597308">
        <property type="protein sequence ID" value="KER19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL597308">
        <property type="protein sequence ID" value="KER19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177103.1">
        <property type="nucleotide sequence ID" value="XM_009178839.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177104.1">
        <property type="nucleotide sequence ID" value="XM_009178840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z126"/>
    <dbReference type="STRING" id="6198.A0A074Z126"/>
    <dbReference type="GeneID" id="20326144"/>
    <dbReference type="GeneID" id="20326145"/>
    <dbReference type="KEGG" id="ovi:T265_11976"/>
    <dbReference type="KEGG" id="ovi:T265_11977"/>
    <dbReference type="CTD" id="20326144"/>
    <dbReference type="CTD" id="20326145"/>
    <dbReference type="OrthoDB" id="6258810at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000014">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11466" checksum="B5C1B48EBC2D3933" modified="2014-10-01" version="1">MNCRLINSTTVGKSGRAIHLTGNWFPKFGQFHACCLLYRGDVVPKDVNAAITKIKTQKTVQSVDWCPTGFKVGLNYQPPTVVPGGDLAKVQQALCMLSNTTVVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2H0</accession>
    <name>A0A074Z2H0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596981">
        <property type="protein sequence ID" value="KER21251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174998.1">
        <property type="nucleotide sequence ID" value="XM_009176734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2H0"/>
    <dbReference type="GeneID" id="20324546"/>
    <dbReference type="KEGG" id="ovi:T265_10378"/>
    <dbReference type="CTD" id="20324546"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12122" checksum="305B3F84CF74B492" modified="2014-10-01" version="1">MFLPERSMTNTNSVFPPCFEENLEKSGKNCAIMQSMVVIPDFNEIPGSATAKERRYYDSDLRGVERLCHPLHMPSFYHACRTIVSKPLPDQHIKTAANAGHRDKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Q6</accession>
    <name>A0A074Z2Q6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596974">
        <property type="protein sequence ID" value="KER21346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174917.1">
        <property type="nucleotide sequence ID" value="XM_009176653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Q6"/>
    <dbReference type="GeneID" id="20324485"/>
    <dbReference type="KEGG" id="ovi:T265_10317"/>
    <dbReference type="CTD" id="20324485"/>
    <dbReference type="OrthoDB" id="5962323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="102"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="467" mass="52329" checksum="DBFFF5623ED3E4FF" modified="2014-10-01" version="1">MSAEELLRNRTRFVILSTQDYIEAARVLVQAGLLNDSQSLLVPTPRNGTLLMTRDISAFLPHTNLLKNGSAKLSDSFCSPYHRRIFPQLFVQTIIMIFTVLINSLTSLVFVRRAMRNPTNTVLLAIALSDLFTVVLPLPIYLLDLTGLVQDTEPSIAEGYLRVYLTVILPTAWHTASIWYTVILAIQRFLYVQFPLKATKFVLCRQVPLSITVVATCMLAFVLFVPIMAITKYYYVLTYVVADEAQDGLAFLDSSIHVQKCTQMHQDTYFSLLLFRVVLVNVIPCVALTILTIHLTLALNRFASKRKRLLSNSTNLVKKCQSEQKQQALDTEKCAVDASQVTNGVQSSLKPSSSSTANSGTATTSSRPGDKDSTSRMLLVVLGIFLGVEVPTTIGLCIYYIQRDPPHWIETVLGTCTTLVVLSYPANFFVYLIMSKPFRTTFKMTFPKLWNVCSSLRRRSVARHNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2U9</accession>
    <name>A0A074Z2U9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 300</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFAP300 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596976">
        <property type="protein sequence ID" value="KER21313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174946.1">
        <property type="nucleotide sequence ID" value="XM_009176682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2U9"/>
    <dbReference type="STRING" id="6198.A0A074Z2U9"/>
    <dbReference type="GeneID" id="20324509"/>
    <dbReference type="KEGG" id="ovi:T265_10341"/>
    <dbReference type="CTD" id="20324509"/>
    <dbReference type="OrthoDB" id="10259249at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029416">
        <property type="entry name" value="CFAP300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31078:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14926">
        <property type="entry name" value="CFAP300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="29654" checksum="430B33B93D460EB4" modified="2014-10-01" version="1">MTRTGFCVGDNAFSFTELKGRTYPSITSKGAIESLMKWSMKGRLHARTFSFDENFKLYDHNIFIGCLLKSPGVVRALKEDGLAVPEYRQLLVEKVPCGSTEMTICSKIKALTARENGMIKKCYDDVIQSVLVSDELRKFFLDEEHYPFSEVSAAQRAEFLFRLFAHVCIGGELCQSEENIDVYIEFTRKLYRDLLSVQKNPDTKELQIVSLVYKVELEDDTGVVFPSTVRHPNTFFYAIVDPFKRNVILLYHIFGCGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z371</accession>
    <name>A0A074Z371_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596961">
        <property type="protein sequence ID" value="KER21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174736.1">
        <property type="nucleotide sequence ID" value="XM_009176472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z371"/>
    <dbReference type="STRING" id="6198.A0A074Z371"/>
    <dbReference type="GeneID" id="20324346"/>
    <dbReference type="KEGG" id="ovi:T265_10178"/>
    <dbReference type="CTD" id="20324346"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="18139" checksum="098FFF75BCD1C357" modified="2014-10-01" version="1">MVGAFPVFKLGSLALKQVSKPIVSFMKQRAKSNMFFRQYICLPPAQLYHMWETRLKLRILGLSKPKEVAKLSEDAAADLGAEMLGEILMFCFGAAILFYEYRRQARKEANKEDNIQKTFDELTNQINELSTLIQIHEARLREHTRLMAKITSDEHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Q5</accession>
    <name>A0A074Z3Q5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596946">
        <property type="protein sequence ID" value="KER21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174546.1">
        <property type="nucleotide sequence ID" value="XM_009176282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Q5"/>
    <dbReference type="STRING" id="6198.A0A074Z3Q5"/>
    <dbReference type="GeneID" id="20324201"/>
    <dbReference type="KEGG" id="ovi:T265_10033"/>
    <dbReference type="CTD" id="20324201"/>
    <dbReference type="OrthoDB" id="10029558at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="963" mass="104463" checksum="A10CB56C7EA9156B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Y4</accession>
    <name>A0A074Z3Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein SEC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_09997</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">Secretory vesicle membrane</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596943">
        <property type="protein sequence ID" value="KER21758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174498.1">
        <property type="nucleotide sequence ID" value="XM_009176234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Y4"/>
    <dbReference type="STRING" id="6198.A0A074Z3Y4"/>
    <dbReference type="GeneID" id="20324165"/>
    <dbReference type="KEGG" id="ovi:T265_09997"/>
    <dbReference type="CTD" id="20324165"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000961">
        <property type="entry name" value="Ras-related protein Rab-8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER21758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="353" mass="40057" checksum="F15633003ECCBC72" modified="2014-10-01" version="1">MPCLNKAWPTGFLPLTQPTHGGDIVRKFSSSEHTFIRQNFLSFRVEGACNDLPPTVVHAPSRTQFKALLGTYLCERQPLTARNKSDPGNLDKRLDPVYPSLLLIGDSGVGKTCLLFRFSEDDFNSTFIATIGIDFKIRTIDIDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDVTNAKSFKNINLWMRNIDQHANQDVEKMLLGNKCDMVDQRQVTREEGQDLANMFSIPFLETSAKSGASVDDAFRQLARDIKVKMEKKMDMAGPPKQDLKNLNSGRHKRQFWRCSFKQCGWIKSGRTCVPGQSPIKNKIGTQNIRLTENSGTPPHDELQKIRNRSWVVEEFSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4J3</accession>
    <name>A0A074Z4J3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adaptor complexe medium subunit family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Stoned B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174265.1">
        <property type="nucleotide sequence ID" value="XM_009176001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4J3"/>
    <dbReference type="STRING" id="6198.A0A074Z4J3"/>
    <dbReference type="GeneID" id="20323986"/>
    <dbReference type="KEGG" id="ovi:T265_09818"/>
    <dbReference type="CTD" id="20323986"/>
    <dbReference type="OrthoDB" id="10063141at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012320">
        <property type="entry name" value="SHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51070">
        <property type="entry name" value="SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHD" evidence="6">
        <location>
            <begin position="512"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="682"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="121308" checksum="67EFFA75A9251F32" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z611</accession>
    <name>A0A074Z611_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596894">
        <property type="protein sequence ID" value="KER22518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173728.1">
        <property type="nucleotide sequence ID" value="XM_009175464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z611"/>
    <dbReference type="STRING" id="6198.A0A074Z611"/>
    <dbReference type="GeneID" id="20328995"/>
    <dbReference type="KEGG" id="ovi:T265_14829"/>
    <dbReference type="CTD" id="20328995"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="424" mass="48231" checksum="DE61AA8ED679A4A9" modified="2014-10-01" version="1" fragment="single">VQLLGRPLPCNRFFPRDFLSSKPKSPGPNLTVESAFAALGLDVNSSPEQCRESYLRLAKKLHPDSSVCSSGASKGKDGYESKASAAFQHLHEAYLIAYEAATSVRNQKLPNQDTQFDVDESVVRHRAPQHRQYLETDSANLGTAVVSGMTPSERQKQLQTQRFVRGVYASADYRLQRLSESMVCPDSDETTELTPVTRRPTKKKPLSLIERMADELIEESMRRGDFDNLQGHGRPLPEHPSHHEIFVDHSTHKLTRILANQGYLPEWIQQGKELRTQWENSIAKLRKLYSQIDSPHTNMLWKKAVLEFQEEAKRINRSIDRYNLMVPALHLQRCHVDASTIVQEILKSKETNVDDTIKESSDSAPTRSSVDDEDEGLGSNNNNTGDISDKNIWDPRYIGELMRDFYRELAKAFVSSLRGFKNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z639</accession>
    <name>A0A074Z639_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transmembrane protein 11 mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173716.1">
        <property type="nucleotide sequence ID" value="XM_009175452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z639"/>
    <dbReference type="STRING" id="6198.A0A074Z639"/>
    <dbReference type="GeneID" id="20323574"/>
    <dbReference type="KEGG" id="ovi:T265_09405"/>
    <dbReference type="CTD" id="20323574"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER22543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32126" checksum="6B60750EF980EE26" modified="2014-10-01" version="1">MKPKQTTVLRQQSLPFSFFAFFIGSLLMNTDKKTYAVIRAVYNNHHAPEDFERELDFVLSRKVSLVIIEPESLGEVTWRWIRTGNWLHKTAVICGFSALATAGFAAFWNSHHFHILSSSSSLHSQWLNDTHAGTALLILTPRLLRMSTTFFSGLSSVAASFYALFWQWDPCCKYQVASSLSSLPRGLRSIMNGSHKNPYRSSNGSPTCLGSVGNSPNGSSGLSQMTGNNGRIRPVITENPSHPYGPPLRPVVLIHRDDGRRKLLHNTLAVSSTVVAVYVLYQWSQPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z679</accession>
    <name>A0A074Z679_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596997">
        <property type="protein sequence ID" value="KER21062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175190.1">
        <property type="nucleotide sequence ID" value="XM_009176926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z679"/>
    <dbReference type="GeneID" id="20324698"/>
    <dbReference type="KEGG" id="ovi:T265_10530"/>
    <dbReference type="CTD" id="20324698"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14742" checksum="9C390637736FDA94" modified="2014-10-01" version="1">MWEGCNLPNRSRPTNTSMNLNPGAVIQTVSSHLDRCEWREIQPKLRMTTTVLDRENRLSTVAAEDGGHQSYHHTHYYKLTQRQPIRPSPALLRLEAISELQADTTFQNSSDRAGQPYMTNRDAYCGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z726</accession>
    <name>A0A074Z726_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Groucho/TLE N-terminal Q-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596870">
        <property type="protein sequence ID" value="KER22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173269.1">
        <property type="nucleotide sequence ID" value="XM_009175005.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z726"/>
    <dbReference type="GeneID" id="20328900"/>
    <dbReference type="KEGG" id="ovi:T265_14734"/>
    <dbReference type="CTD" id="20328900"/>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001072">
        <property type="entry name" value="Transcription factor unc-37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="7">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1245"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1321" mass="136863" checksum="0FAB6C4E5BB45302" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7A1</accession>
    <name>A0A074Z7A1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174792.1">
        <property type="nucleotide sequence ID" value="XM_009176528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7A1"/>
    <dbReference type="GeneID" id="20324387"/>
    <dbReference type="KEGG" id="ovi:T265_10219"/>
    <dbReference type="CTD" id="20324387"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="16368" checksum="5441E7D0D7909692" modified="2014-10-01" version="1">MSVVANRLFPKPVDRAHITTRGAFVTSAGYLKYSNGIRESFCATTNRNFDFTGLAQKLLNNFFRLKSGNLNDDIYQCATKSCGVDWEYPWNTQMKSVSKNYLVRRGVEYNMDRNKKKAFAAGLFIGKHELNSYRLLDREASCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7S0</accession>
    <name>A0A074Z7S0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173115.1">
        <property type="nucleotide sequence ID" value="XM_009174851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7S0"/>
    <dbReference type="STRING" id="6198.A0A074Z7S0"/>
    <dbReference type="GeneID" id="20328867"/>
    <dbReference type="KEGG" id="ovi:T265_14701"/>
    <dbReference type="CTD" id="20328867"/>
    <dbReference type="OrthoDB" id="9972932at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF33">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703851" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="248"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="389" mass="43638" checksum="1108AE09B886E741" modified="2014-10-01" version="1">MPKSGYEILCLIILPPLAHAFVPQITDEIVTAVVQEKGTAYLNCTALIDESQESQISWYRTLDKQQIASGTTLKEPVRRGPHGVSKYAVRFLPGRPPYAPNLAGVDLTKLRTYQLIVRFVDINDANTQFRCVIELRTTPREEWPQAFGRIVVKRAPEILPGLTSQIVNEGEPLRLDCIAQGSPAPKVSWTRANGRPLSLPGFPQRIYNTTLYLPRVDRYDRGVYRCYAVNNVAESAQYDVMVEVNYAPHVREARFKGAYGQAPDGNYDITLECIVNGYPDPDLLWYRGVYDPITNNVPLYDNNRYELEKAQSYGAAGTNITDVFSTLLVRNVRVGDYGNYSCRAENKYGSSFVVMYLFYQSICQGAYCPMLGAISMTARLNPDGTPVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8W7</accession>
    <name>A0A074Z8W7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172679.1">
        <property type="nucleotide sequence ID" value="XM_009174415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8W7"/>
    <dbReference type="STRING" id="6198.A0A074Z8W7"/>
    <dbReference type="GeneID" id="20322749"/>
    <dbReference type="KEGG" id="ovi:T265_08570"/>
    <dbReference type="CTD" id="20322749"/>
    <dbReference type="OrthoDB" id="7487361at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="571" mass="65531" checksum="627929B845C34981" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9U5</accession>
    <name>A0A074Z9U5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Little elongation complex subunit 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596904">
        <property type="protein sequence ID" value="KER22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173910.1">
        <property type="nucleotide sequence ID" value="XM_009175646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9U5"/>
    <dbReference type="GeneID" id="20323712"/>
    <dbReference type="KEGG" id="ovi:T265_09543"/>
    <dbReference type="CTD" id="20323712"/>
    <dbReference type="OrthoDB" id="6288737at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019535">
        <property type="entry name" value="ICE2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14633">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14633:SF3">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10505">
        <property type="entry name" value="NARG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Little elongation complex subunit 2 C-terminal" evidence="2">
        <location>
            <begin position="625"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="887" mass="97614" checksum="9517C00363538035" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA22</accession>
    <name>A0A074ZA22_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172131.1">
        <property type="nucleotide sequence ID" value="XM_009173867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA22"/>
    <dbReference type="STRING" id="6198.A0A074ZA22"/>
    <dbReference type="GeneID" id="20322326"/>
    <dbReference type="KEGG" id="ovi:T265_08147"/>
    <dbReference type="CTD" id="20322326"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="264" mass="29095" checksum="ECB04C5C0BA38D99" modified="2014-10-01" version="1">MAVPRFELRTSDMRDPQDCKLVSLVNVSQSARPSRVGKYFSHWGMGLKVLCTSSLNANKHHCGVSTHANKLPSLANKLTTSSRRRQRGFNPSQMPNPAAGHPLHAVCPIMPAEYHTTHAYGSYAFPPVYPASHSQSYPNLVRTGHVSGTPDPIMHQMSNNNDYHLFARHPRGSGIDGNTSTFGYQSSATAYPELTQEYKDGPCPTTVVPLPSYDYAMGRLDALNGNVTVSDEDGQEREDELAREKASPPSIVNTFVRQRDGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA29</accession>
    <name>A0A074ZA29_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597093">
        <property type="protein sequence ID" value="KER20095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176158.1">
        <property type="nucleotide sequence ID" value="XM_009177894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA29"/>
    <dbReference type="GeneID" id="20325445"/>
    <dbReference type="KEGG" id="ovi:T265_11277"/>
    <dbReference type="CTD" id="20325445"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8338" checksum="25BB85ADFC6F4EA6" modified="2014-10-01" version="1">MDILPDDEECPPFSVKVGGEENKGTTVYFAAWSVVSGCMPKTGVEPTDGQLTRPYFECCAQEKNEDPAATTLEDGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBL2</accession>
    <name>A0A074ZBL2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175629.1">
        <property type="nucleotide sequence ID" value="XM_009177365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBL2"/>
    <dbReference type="STRING" id="6198.A0A074ZBL2"/>
    <dbReference type="GeneID" id="20325039"/>
    <dbReference type="KEGG" id="ovi:T265_10871"/>
    <dbReference type="CTD" id="20325039"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="18443" checksum="AECB2DEA6B25014C" modified="2014-10-01" version="1">MCHGISAQQLEELFQSLDRDGNGSVDREELAVSLKEAGIPGKNAEHSGVSNGPYIGCTTLQLFTHTKVPRQQNFNRTLVSGSNFAALVKVSRNIEYRWKRLFVTLDSDRSGKVDKRELQQMFNEMGMHFALSTLEDWIADHDVDGDGKLTYQEFMGFVAEQIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC04</accession>
    <name>A0A074ZC04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_07572</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171393.1">
        <property type="nucleotide sequence ID" value="XM_009173129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC04"/>
    <dbReference type="STRING" id="6198.A0A074ZC04"/>
    <dbReference type="GeneID" id="20321751"/>
    <dbReference type="KEGG" id="ovi:T265_07572"/>
    <dbReference type="CTD" id="20321751"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="450"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER24841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="885" mass="98440" checksum="7EF75B60BA398E0F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCF5</accession>
    <name>A0A074ZCF5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171279.1">
        <property type="nucleotide sequence ID" value="XM_009173015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCF5"/>
    <dbReference type="GeneID" id="20321661"/>
    <dbReference type="KEGG" id="ovi:T265_07482"/>
    <dbReference type="CTD" id="20321661"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12704" checksum="9DBD5A4856F29805" modified="2014-10-01" version="1">MENLSRFKIPSNEQVQQEIFTGNAKKRNQIFGGLLRIKLTLVSLLVMANSLLCASAVGKFDDTLAERYPFRKCLQECALSAEPLLDEYEYCAWQCSRLREKRGKFFMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCI8</accession>
    <name>A0A074ZCI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171251.1">
        <property type="nucleotide sequence ID" value="XM_009172987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCI8"/>
    <dbReference type="STRING" id="6198.A0A074ZCI8"/>
    <dbReference type="GeneID" id="20321637"/>
    <dbReference type="KEGG" id="ovi:T265_07458"/>
    <dbReference type="CTD" id="20321637"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705044" description="Nicastrin" evidence="11">
        <location>
            <begin position="23"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="12">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="716" mass="79621" checksum="7CFE518703D43417" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDB1</accession>
    <name>A0A074ZDB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170952.1">
        <property type="nucleotide sequence ID" value="XM_009172688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDB1"/>
    <dbReference type="GeneID" id="20321402"/>
    <dbReference type="KEGG" id="ovi:T265_07223"/>
    <dbReference type="CTD" id="20321402"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13954" checksum="C783B242C79B0EB9" modified="2014-10-01" version="1">MNRVNHNRFEANQKTRKFAAHDDVELHAYSVPYNFVLYSSNSQSDDLWLKLLGTGRDTQTSVDGDFLWEKGDFRCTATTEFNYGLTSSGINFTHKFMEFVPPMTPETMKHLYDDSESTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDM1</accession>
    <name>A0A074ZDM1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170843.1">
        <property type="nucleotide sequence ID" value="XM_009172579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDM1"/>
    <dbReference type="STRING" id="6198.A0A074ZDM1"/>
    <dbReference type="GeneID" id="20321314"/>
    <dbReference type="KEGG" id="ovi:T265_07135"/>
    <dbReference type="CTD" id="20321314"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="113"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="383" mass="42217" checksum="AF9FD099EA480403" modified="2014-10-01" version="1">MFPLREFHGRSLRASLIVATSLLALLLWHGHRNYPAILRPAVYRGYRLKKNFAGVFDAVTAGSNSLPNTTYYDYTQMNTSLVDQTEPSNWTDHAKQLLRLNGVALSNVVLTHIASRVVAIVQVTPYFQSVKPRHICGGTALSSEWIITAAHCVAHLKKSLRLLKVARFMPNTTSGLNHDSHLVRGLPEHPIEKIFVHPNFDRKNILSDDIALVKINSKKIDDILPWGEEVGDVSALEQLEPVSSEAVPCLVAGAGRLRHNAVLPHEVENQYLHVAIVTRKSCMGLLNLLNHKVPENVTRRRLQSDTLICAGGQLDDGDTCQGDSGGPLICAWYLAGIASSGIGCGKYGIPSIYTRIQAYTQWINSNYKPAIISSAFNSVNTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDX4</accession>
    <name>A0A074ZDX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170771.1">
        <property type="nucleotide sequence ID" value="XM_009172507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDX4"/>
    <dbReference type="STRING" id="6198.A0A074ZDX4"/>
    <dbReference type="GeneID" id="20328366"/>
    <dbReference type="KEGG" id="ovi:T265_14200"/>
    <dbReference type="CTD" id="20328366"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER25481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="501" mass="55330" checksum="580DB7A6E5980A98" modified="2014-10-01" version="1" fragment="single">HLVPSPEGLCSLSDAIKASAEQPNGAPNVRVFDVDTGDLLKEYIHRSTGGWQPQWTNDSAYCAVRIDGDVQLYNKGQFDSKPTGRLAVKGMCHFSLSPSSIVPSVAVYVPCQKGQPSSVRVFQWHSGQFQLITSKSFYRADTVQLCWNDRGMDLLTLSSTKTSEESYYGDQGLFYLTTKRSSDSAVVTMPRKGPIYDVAWRPDSSAGTQNEARSTEQLFAVCHGFVPASVTVFGTDCEPRFNFAGLGNLPGDMCVWDFARQERLSTFKTTDITSVTWMNDGEHLLMATTTPRLRVNNGFGIWHYSGKKLFFQRVEPRAVPRPATMDLPAATDHELYQVFVMPQDHLPPAPRPKKFDPVLQVSSGTGTTSKGGKYIPPALRNRSEVAKQAVAAAHTLDSVKGQYQPPAARPNLPVGMDPNMLDTKKPKKRKKPAAEKSEPSGEPHPPGMGNKQASQLRKKLNEIEKLKTERAAGKQLAFNQIEKIDREEQIRAELANLTLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHF7</accession>
    <name>A0A074ZHF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173614.1">
        <property type="nucleotide sequence ID" value="XM_009175350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHF7"/>
    <dbReference type="STRING" id="6198.A0A074ZHF7"/>
    <dbReference type="GeneID" id="20328971"/>
    <dbReference type="KEGG" id="ovi:T265_14805"/>
    <dbReference type="CTD" id="20328971"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40692" checksum="330EBB0BF06C1A43" modified="2014-10-01" version="1" fragment="single">IHAGKLLKDEVCLESVFRDSTGVQTIHLVCRGPKATQPPQTTSTPSNQDTNSDNLSDITPEDMAEYQRGYYEYLQQFYMNSSDYCPVTNPSSVPFVNFPFQNPWAPAPVGGYIGAQNPWQYPPAVLPPVSQTEVEIAPPNRDNLPAAAEGNQWFRGARAFLADLGVVNADGVDGAAPAGGNQGALQQQQQAMVVGNPMAGGFMGAEEMGENAGNMDIVDRFYMLFRLCLFIGLCFAYSSLDKAIIVFSVAAYVYFYNIYRRHAAVRQAAAQAQQALQPVPQGEPQPTDRPQAQSVEDSGVGDTTDADQQVRLRPITSENQSAPAGNTEPVQADRQPPFVRLTGTLRLVANTSYQFVSSLLTSLIPEQPPPIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIJ9</accession>
    <name>A0A074ZIJ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009172370.1"/>
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    <dbReference type="GeneID" id="20321143"/>
    <dbReference type="KEGG" id="ovi:T265_06964"/>
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    <dbReference type="OrthoDB" id="6239126at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
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        <property type="entry name" value="Parvo_NS1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="55"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="263" mass="30758" checksum="758DF7A63E954BBA" modified="2014-10-01" version="1">MKGLIEAYDARSYNEFYMAMSCDDRDDIYDEYGPQWKETAEHSINNYIAGMLSKQLAMRFEEILMTNYHNRQCQHPANTLDGEYWLDQLMSANKINKQQFLTDLTLVMNKVCTRKNAFVIEGPTTTGKTLFVKLIAENYIYGTVQRSGDHSQFFLMNLLNKALALMEEPRITQLTVNDFKELLGGNPFDIHVKHQKDERLQRLPVLITTNNNLVYYVLDPDGKAILERCFYYKFLVKVGSEELPEPPCHLCTCHFRNWYFKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIM9</accession>
    <name>A0A074ZIM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596862">
        <property type="protein sequence ID" value="KER23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009174829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIM9"/>
    <dbReference type="GeneID" id="20323080"/>
    <dbReference type="KEGG" id="ovi:T265_08901"/>
    <dbReference type="CTD" id="20323080"/>
    <dbReference type="OrthoDB" id="10052054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="272" mass="31124" checksum="D661046E8ADF5D3C" modified="2014-10-01" version="1">MFVHTNTDDVINISVAKLSNANKKFPRRTSVTPAAASYTRPSNESSNKTGRLSLASASSDRNSIEASGFNAGEKLRRMSTLFSIDRSKTREAIMAVLEDPARTEYRKLKNTNEHLTAEWKQLRKFVEQLASDYESTRQLDPIRRYRQLQAMTKRTVMHLRLTEVGCLSGDPLKAEVPVQGSILQSEAKEREIEKRIMRMCENYTVEELGPENRRLRENNDRLETRIQLIVQTINELDVLYRSSKSDSFVKRYGALREAIKEIVTNKELIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJB7</accession>
    <name>A0A074ZJB7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169166.1">
        <property type="nucleotide sequence ID" value="XM_009170902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJB7"/>
    <dbReference type="GeneID" id="20328026"/>
    <dbReference type="KEGG" id="ovi:T265_13859"/>
    <dbReference type="CTD" id="20328026"/>
    <dbReference type="OrthoDB" id="10021571at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="463"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="88645" checksum="1E5FD0928EFF927B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJH2</accession>
    <name>A0A074ZJH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596846">
        <property type="protein sequence ID" value="KER23515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172735.1">
        <property type="nucleotide sequence ID" value="XM_009174471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJH2"/>
    <dbReference type="GeneID" id="20328789"/>
    <dbReference type="KEGG" id="ovi:T265_14623"/>
    <dbReference type="CTD" id="20328789"/>
    <dbReference type="OrthoDB" id="6283219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9856" checksum="2A2301717CCB3AB2" modified="2014-10-01" version="1">MIWPELQGGQSVYRRFDHWAHYGYSSALSDLAQQLAVCEVTSTEMVYSSHLNSQHTFQTIVRGLPSLLRFKWAKAVANIRREDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKT1</accession>
    <name>A0A074ZKT1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168334.1">
        <property type="nucleotide sequence ID" value="XM_009170070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKT1"/>
    <dbReference type="GeneID" id="20319328"/>
    <dbReference type="KEGG" id="ovi:T265_05146"/>
    <dbReference type="CTD" id="20319328"/>
    <dbReference type="OrthoDB" id="10512644at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11701" checksum="BCE135BFF5F9AC01" modified="2014-10-01" version="1">MVYQKQHQLVKLKKVAPVECMVNRVHQASRSARTLSFTWRRMMRRVSRKDTVLSEIQCLDEVGRVAPQADAPALRSALDTFSQWPFISDTVPSGRHSRSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLE7</accession>
    <name>A0A074ZLE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172069.1">
        <property type="nucleotide sequence ID" value="XM_009173805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLE7"/>
    <dbReference type="STRING" id="6198.A0A074ZLE7"/>
    <dbReference type="GeneID" id="20322277"/>
    <dbReference type="KEGG" id="ovi:T265_08098"/>
    <dbReference type="CTD" id="20322277"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28588" checksum="7350BF36953E52E5" modified="2014-10-01" version="1">MTGGSSTADVIRKKLDTMRLEIEELQNTVFDTTEKIKTEVALKEAVEAEVVELQRQTTTLEELLKQGSTRLAETLARLDEATKSAEESERHWRGIENRLYTYDKNIEELEKTASDANFAAEEADRKYKEVERTLTVTEENLHVAESRVAATENRIKEMEATLKQLTGSLKALEIKQEESSEREKALEDRLTMLKKHVEEAESRASAAEAEVNRRGQEIKRTRELIKAEHSAYESLRREMDTMVNEFHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLG5</accession>
    <name>A0A074ZLG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metal cation transporter, ZIP family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168087.1">
        <property type="nucleotide sequence ID" value="XM_009169823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLG5"/>
    <dbReference type="STRING" id="6198.A0A074ZLG5"/>
    <dbReference type="GeneID" id="20327799"/>
    <dbReference type="KEGG" id="ovi:T265_13632"/>
    <dbReference type="CTD" id="20327799"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74796" checksum="92EDC575F3E2A643" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLH2</accession>
    <name>A0A074ZLH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_06137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169594.1">
        <property type="nucleotide sequence ID" value="XM_009171330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLH2"/>
    <dbReference type="STRING" id="6198.A0A074ZLH2"/>
    <dbReference type="GeneID" id="20320319"/>
    <dbReference type="KEGG" id="ovi:T265_06137"/>
    <dbReference type="CTD" id="20320319"/>
    <dbReference type="OrthoDB" id="409763at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
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        <property type="entry name" value="ECH/Chromodomain_protein"/>
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        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
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        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF11">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="757"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1032" mass="112913" checksum="6BECA83EFC50B738" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLK4</accession>
    <name>A0A074ZLK4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14466</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009173779.1"/>
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    <dbReference type="KEGG" id="ovi:T265_14466"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
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        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
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        <property type="entry name" value="GPR158/179"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF26">
        <property type="entry name" value="SMOG, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_3"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1123"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1181"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1538"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1570"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1603"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1642"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1774"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1805"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="1533"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="861"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2001"/>
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        </location>
    </feature>
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        <location>
            <begin position="2010"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2042"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER24230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2053" mass="228993" checksum="5C8243C9E6B16E3D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLM1</accession>
    <name>A0A074ZLM1_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">T265_04851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER28248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009169705.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZLM1"/>
    <dbReference type="GeneID" id="20319033"/>
    <dbReference type="KEGG" id="ovi:T265_04851"/>
    <dbReference type="CTD" id="20319033"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41323" checksum="11EF47A808354C2E" modified="2014-10-01" version="1">MSLWVDKYAPTSLQKLDYHQQEAAALKNLVDSGNFPHLLVYGPSGSGKRTRIMCLLRELYGSGVDRLRTETHNFLTPSNKKVTVSTVSSNFHLEVNPSEVGIYDRVVVQELIKTMASTAQLDSAQQRDFKVVVLHEADHLTKDAQHALRRTMEKYISTCRLILSAESISKIISATRSRCLPIRVAAPSIDQIVHILKNTARREGQSMPTELAERIANASERNLRRALLLAEVAKWQHSPMSAEQPVQLPDWQVFLAETASAILAEQSPRKYLDFKSALDSVERFALLNTLVTVYASEVFLHFDCLVDNLLGSCDGNLKLELVQLAAEYEHRLQLGQKPIFHLEAFVISFMAIYKRFVEDALGSGMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM46</accession>
    <name>A0A074ZM46_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168105.1">
        <property type="nucleotide sequence ID" value="XM_009169841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM46"/>
    <dbReference type="GeneID" id="20319146"/>
    <dbReference type="KEGG" id="ovi:T265_04964"/>
    <dbReference type="CTD" id="20319146"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="18476" checksum="77B91BCF2399A3D0" modified="2014-10-01" version="1">MNRRLPESEMIYLKCWLTSVDIEPGRCVSPGGLAKDEISIRIGKARAAFANIRHLWRRRDISFSPLPANSAASVFLDGDPRRAISMTGDIVKYGPVAPSVALVHPSYCLQCIAPSPTPTPFDSPLTVLDLCTNLSAPACNAQLPTSPPKPSVIETAAVTTTVRRVRRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM95</accession>
    <name>A0A074ZM95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168137.1">
        <property type="nucleotide sequence ID" value="XM_009169873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM95"/>
    <dbReference type="GeneID" id="20327819"/>
    <dbReference type="KEGG" id="ovi:T265_13652"/>
    <dbReference type="CTD" id="20327819"/>
    <dbReference type="OrthoDB" id="10017343at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="495" mass="55706" checksum="2A9D95514F4CA48C" modified="2014-10-01" version="1">MKIQSHRIDQWENKKAINCGQNKHIPHVPFKSCLALYEELIKAERHLEEEAIGEDKLLSQEPEIGQLTQQIYENAPTLLGTISVLKSIQLDTAKLFTSLLKTLRQPTTGFALLGTHQAHSLSFRQPYVLLGPETKLVQRFFLSKLSSAISRRGSKTPVFTLAVERRRRRLKNQWVEEQPRPFAPLYINLGRPDISAEISNGLLSHALDQIECGSHLESTEDPNEPASGQNSTFIDSESRSTTEGVTVKEFFFQDMLFAQLCCLLWLLEQMLRVEREKEVGSTSISTSWKWKKSAEGDSPAAEIFPRDVERAWRQFVLQPDPLAKPRKRLASLTGLKWGSRPSSRNSSIWRVSSSMRSARDSGRTSASNTDRALANVRKLLSASSLGDNLVCEKPRKASSSSRITPESVALSTSDAKSSSNNQLPTNLPGRNVKFTENVELLDFDEREEEEQHPLSQQYVLICQFAKCILQPLHNFPTVFYHFATQACGIPKLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMA0</accession>
    <name>A0A074ZMA0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171781.1">
        <property type="nucleotide sequence ID" value="XM_009173517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMA0"/>
    <dbReference type="GeneID" id="20328582"/>
    <dbReference type="KEGG" id="ovi:T265_14416"/>
    <dbReference type="CTD" id="20328582"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="527" mass="59072" checksum="01C22B14729FC6EF" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMJ4</accession>
    <name>A0A074ZMJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596804">
        <property type="protein sequence ID" value="KER24580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171654.1">
        <property type="nucleotide sequence ID" value="XM_009173390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMJ4"/>
    <dbReference type="GeneID" id="20321957"/>
    <dbReference type="KEGG" id="ovi:T265_07778"/>
    <dbReference type="CTD" id="20321957"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="8973" checksum="D1EA13B9C62C262C" modified="2014-10-01" version="1">MAQEVEITKQYSAMRIEGLSFGPQELLFWLQTSRDEEAGAAASTGDGKKRRPSQRSCLLEKRQQEQLKTIGQGAKRPYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMK3</accession>
    <name>A0A074ZMK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596804">
        <property type="protein sequence ID" value="KER24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171660.1">
        <property type="nucleotide sequence ID" value="XM_009173396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMK3"/>
    <dbReference type="STRING" id="6198.A0A074ZMK3"/>
    <dbReference type="GeneID" id="20321963"/>
    <dbReference type="KEGG" id="ovi:T265_07784"/>
    <dbReference type="CTD" id="20321963"/>
    <dbReference type="OrthoDB" id="10397273at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7557" checksum="E98B1D03391A080B" modified="2014-10-01" version="1">MKIVHFAHGLLQSKFEALKRSHAEEKKKLEDKKRVLEEEMAAFERRKQWAEQAKMGNTFKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN12</accession>
    <name>A0A074ZN12_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171516.1">
        <property type="nucleotide sequence ID" value="XM_009173252.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZN12"/>
    <dbReference type="GeneID" id="20321852"/>
    <dbReference type="KEGG" id="ovi:T265_07673"/>
    <dbReference type="CTD" id="20321852"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="384"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="719"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1815" mass="201004" checksum="C440F7041B35985E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNB7</accession>
    <name>A0A074ZNB7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167344.1">
        <property type="nucleotide sequence ID" value="XM_009169080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNB7"/>
    <dbReference type="GeneID" id="20318541"/>
    <dbReference type="KEGG" id="ovi:T265_04359"/>
    <dbReference type="CTD" id="20318541"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="265" mass="30004" checksum="6D4A97519D12C535" modified="2014-10-01" version="1">MQGGKPGNDYQFRIATNQTFQTLNEVLFVELQALRGVQNCFLIIRRLNDLRAPSQWLVAVMAFLAAIMSADLDDIQRSLSRGTQALIEVRSVQSTNSFNPDGKSQYSSGWRKITMEQAPTGVAEYSIIALREDTILSRRMRSILEFTALPKGVDPINSSNLLPTGIQLFPDRPFVEYLTQFLTNILDTIEKAWTRRGHCWDCVVPRSRIVDSKLMQQKPRVSTVNSGDELKPHIDKSLQSLACRPSVHNHMATNEYQPCCFIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNP4</accession>
    <name>A0A074ZNP4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167524.1">
        <property type="nucleotide sequence ID" value="XM_009169260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNP4"/>
    <dbReference type="GeneID" id="20318687"/>
    <dbReference type="KEGG" id="ovi:T265_04505"/>
    <dbReference type="CTD" id="20318687"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8720" checksum="94B331F266B06326" modified="2014-10-01" version="1">MSNNARKETKIGACAEHLTKEYIKQCSEGRDGSSGESANLPTEGPWFEFDLRVSTSPVKAWATWRYPDPRASFGWHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP56</accession>
    <name>A0A074ZP56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168672.1">
        <property type="nucleotide sequence ID" value="XM_009170408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP56"/>
    <dbReference type="GeneID" id="20319592"/>
    <dbReference type="KEGG" id="ovi:T265_05410"/>
    <dbReference type="CTD" id="20319592"/>
    <dbReference type="OrthoDB" id="10420466at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6724" checksum="5DD3546744DCA093" modified="2014-10-01" version="1">MTWIRLRSTSDIVRRNSTQIPLYRSQSGAVTAEKPIPCKIGQKVGTLAGPASRRDLIGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPX6</accession>
    <name>A0A074ZPX6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596779">
        <property type="protein sequence ID" value="KER25380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170895.1">
        <property type="nucleotide sequence ID" value="XM_009172631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPX6"/>
    <dbReference type="STRING" id="6198.A0A074ZPX6"/>
    <dbReference type="GeneID" id="20321359"/>
    <dbReference type="KEGG" id="ovi:T265_07180"/>
    <dbReference type="CTD" id="20321359"/>
    <dbReference type="OrthoDB" id="6662575at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER25380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="445" mass="49875" checksum="672EDA18E2A67671" modified="2014-10-01" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDSVRAGPFGQLFRPDNFTFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMSTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSVTFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEEEGEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPZ0</accession>
    <name>A0A074ZPZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596778">
        <property type="protein sequence ID" value="KER25395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170847.1">
        <property type="nucleotide sequence ID" value="XM_009172583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPZ0"/>
    <dbReference type="GeneID" id="20321318"/>
    <dbReference type="KEGG" id="ovi:T265_07139"/>
    <dbReference type="CTD" id="20321318"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="232" mass="26476" checksum="1EC435FEF4F57706" modified="2014-10-01" version="1">MADYTYQVEVVGTCAKYAQPPLTEGNVAVCSKRLLTKGSQKAGHGEREKAFAVELFIRKCQLDQLQTIGQRRQHRDFASLSGMKVEARCVDVFCRKDRAGLQTSRMFEEKLMNANMARLKSSRQKTVHSPSLFNSIIVTAPASSILPYHPQSNDQTERFVDTFRRVFFKRRDPKYFLIFVNFCFELQDGHEIKDNPDYTPVIGFLTNFDGSKRGGTQIHRAHIFENGGRSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH2</accession>
    <name>A0A074ZRH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166605.1">
        <property type="nucleotide sequence ID" value="XM_009168341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH2"/>
    <dbReference type="STRING" id="6198.A0A074ZRH2"/>
    <dbReference type="GeneID" id="20327484"/>
    <dbReference type="KEGG" id="ovi:T265_13317"/>
    <dbReference type="CTD" id="20327484"/>
    <dbReference type="OrthoDB" id="6270412at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="26456" checksum="B8623C7E59748D85" modified="2014-10-01" version="1" fragment="single">DAELLSCFSGNGYIVNRLSNRPITSTEEEVRLWFQTRQPNSSLFHVGSDNRGLSIHILNGWPHIWLQLPDTERLQSEGRVDRQIIAARNSWSPESGVAGIIQLNLHVRPGRYESSRLDDNQWHELILIRQNKQLVRMNQRISNKAFVTFEKYTQSQITLVFTRDSTESLVYGILQLNVLDTGRLMFQLARYWRYRSIVAYRKLLTRKFADLRLIYGLPQLASLITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRW7</accession>
    <name>A0A074ZRW7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170137.1">
        <property type="nucleotide sequence ID" value="XM_009171873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRW7"/>
    <dbReference type="GeneID" id="20320749"/>
    <dbReference type="KEGG" id="ovi:T265_06570"/>
    <dbReference type="CTD" id="20320749"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13005" checksum="9514DBB28A05CE4D" modified="2014-10-01" version="1">MLDNSQVQTTLELGAYGTIRARSDERGVDSPPRCCDTVTPVTVCPVDLPPHRNACIQVKISFRLNLRESSERQLRPVIVISSHSVSCGLSSVNLHRTAVGQTGALTSRPVGGGVPSSYSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS20</accession>
    <name>A0A074ZS20_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3677 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166062.1">
        <property type="nucleotide sequence ID" value="XM_009167798.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZS20"/>
    <dbReference type="GeneID" id="20317524"/>
    <dbReference type="KEGG" id="ovi:T265_03337"/>
    <dbReference type="CTD" id="20317524"/>
    <dbReference type="OrthoDB" id="19938at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053966">
        <property type="entry name" value="INTS1_INTS2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053965">
        <property type="entry name" value="INTS1_R4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="1">
        <location>
            <begin position="499"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="2">
        <location>
            <begin position="2412"/>
            <end position="2506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2571" mass="284313" checksum="0078622326EAF4B8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS96</accession>
    <name>A0A074ZS96_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165944.1">
        <property type="nucleotide sequence ID" value="XM_009167680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS96"/>
    <dbReference type="GeneID" id="20317434"/>
    <dbReference type="KEGG" id="ovi:T265_03247"/>
    <dbReference type="CTD" id="20317434"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8572" checksum="C2F490776D389343" modified="2014-10-01" version="1">MPQAQHKMRSRARKWARKLLAGGGPPFCISSFQSGNLSECISAEDLAGGYITNCLQHLLQPGWADRLPCEDEYGGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSQ1</accession>
    <name>A0A074ZSQ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166149.1">
        <property type="nucleotide sequence ID" value="XM_009167885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSQ1"/>
    <dbReference type="GeneID" id="20327402"/>
    <dbReference type="KEGG" id="ovi:T265_13235"/>
    <dbReference type="CTD" id="20327402"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13324" checksum="4391B652B4E22901" modified="2014-10-01" version="1" fragment="single">SSCALLGCLSVRRAWQLGCKRFITNRGDIVSAGLRDDVISNGEETFATQLPSSANRQTTKAVLKFPSASPSHSRGPTQPCTDDVTSIDDETFAIQLPSSANRPTTKQRTRATYIPPQHRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG6</accession>
    <name>A0A074ZTG6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165496.1">
        <property type="nucleotide sequence ID" value="XM_009167232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG6"/>
    <dbReference type="STRING" id="6198.A0A074ZTG6"/>
    <dbReference type="GeneID" id="20317067"/>
    <dbReference type="KEGG" id="ovi:T265_02879"/>
    <dbReference type="CTD" id="20317067"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="228" mass="26111" checksum="A188CC14142482FF" modified="2014-10-01" version="1">MGYCIAYAPSFFIPLVFAAIMGLPMTVRLTGLSTHCTRSNLEETSTWGCTDKSKCKSDTLIFDGSSWTTFIMQTNQTNDRLSVQFRTREADQLLLYTVIKNLPDADDPTRIQVFMAVYLLNGSLTVAVERYVQNDIPSFQTMSINRQMDCISNYGTCADKQWHQFTQTLAKNTCDRNEKYLWLILRFTGTNEEKIKTIIFDCNFGVLRDRYFVPSHTTRLNGRVPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTJ0</accession>
    <name>A0A074ZTJ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167086.1">
        <property type="nucleotide sequence ID" value="XM_009168822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTJ0"/>
    <dbReference type="GeneID" id="20318338"/>
    <dbReference type="KEGG" id="ovi:T265_04152"/>
    <dbReference type="CTD" id="20318338"/>
    <dbReference type="OrthoDB" id="6248801at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25344" checksum="D8E6F69D673B5AB7" modified="2014-10-01" version="1">MQMVCGQLVDIQAEQFVGDSQNDSGAALPSPILPSLDEESSDITLSVLANRTHEPDDKSSVKVNRRISLYMENPHVSPSDDSPQQRLNLNSQEQENIPPSPVQPSPSWLISRYSPPKLVGLESLLEGRVLRSRRTPLLPSKPNNNMLRFHVFTGQTLDEACQPKFPGAAPLDPKLVLTLTRRRTRLRQQKARRLGFKEIAVSRKTERRLSMLMRTMQENLSSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUQ2</accession>
    <name>A0A074ZUQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596731">
        <property type="protein sequence ID" value="KER27110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169175.1">
        <property type="nucleotide sequence ID" value="XM_009170911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUQ2"/>
    <dbReference type="STRING" id="6198.A0A074ZUQ2"/>
    <dbReference type="GeneID" id="20328035"/>
    <dbReference type="KEGG" id="ovi:T265_13868"/>
    <dbReference type="CTD" id="20328035"/>
    <dbReference type="OrthoDB" id="5978072at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19738" checksum="84DBEC98B87FCACE" modified="2014-10-01" version="1" fragment="single">PETWGTILSATTNKPVWPLCQIGHQQSPIDIQTERLLFDHTLKTFRIIGSDEQLEFIVQNVGQDLQLSFLSNQVFLTGGPLSYYYQIFSARIKFGSASSKGSDHRIDGRSSPGELQIFAYNNELYKNSSQASIHPNGLAAVSVFFKLQIFAYNNELYKNSSQASIHPNGLAAVSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUX1</accession>
    <name>A0A074ZUX1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164954.1">
        <property type="nucleotide sequence ID" value="XM_009166690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUX1"/>
    <dbReference type="GeneID" id="20316629"/>
    <dbReference type="KEGG" id="ovi:T265_02441"/>
    <dbReference type="CTD" id="20316629"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="13063" checksum="DD7004D3AC3D2121" modified="2014-10-01" version="1">MVQQSFNRQTFRPCAAQFVSNETRVSRTLGSTLSLYYVPSPRYKAHRSMPCQNMRWYTRSSGILVEEGEYNWSDLDRRKKIEQKWECSTNRLGLGNERRTWELLDVCSGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVZ3</accession>
    <name>A0A074ZVZ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164630.1">
        <property type="nucleotide sequence ID" value="XM_009166366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVZ3"/>
    <dbReference type="GeneID" id="20327100"/>
    <dbReference type="KEGG" id="ovi:T265_12932"/>
    <dbReference type="CTD" id="20327100"/>
    <dbReference type="OrthoDB" id="10459101at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="17730" checksum="33440EFDC91A0EDF" modified="2014-10-01" version="1" fragment="single">MGAAIFLTNKHFEPQNYSSHPTPAVNGHPHRHFVRSTVTGDFGLKSTIDQDGRDHVKPTPVRHIVVHLEVPESVVWRSRISDKKISKVGPNRLCRMLKNKLGPNIGCTGTKWETGLSEEDSSTTVDSKWLRSLILNELPSIEESGNSLPVSTREPLTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX06</accession>
    <name>A0A074ZX06_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polyprenyl synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168362.1">
        <property type="nucleotide sequence ID" value="XM_009170098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX06"/>
    <dbReference type="STRING" id="6198.A0A074ZX06"/>
    <dbReference type="GeneID" id="20319348"/>
    <dbReference type="KEGG" id="ovi:T265_05166"/>
    <dbReference type="CTD" id="20319348"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47626" checksum="6F8007AEB1D15782" modified="2014-10-01" version="1">MENAKNAGNVRNLHLLIRSTGPRKPLVNEIIRDQIGLLICSRAECLDFSAQYSEQQFSWPPATSNPESWPSKERWTVNMEPPSVSEVPECISLIKRHPAACLDDFPSALFKDDDGLLSQCLSSPFGSIWKKEQPTYLSCSAGVGTMDANRWIQLHKEFDAYYSEFERLLSECARPKNSADELVQLHAGFLIHDDIIDNSPTRRNRTSWFLMQKQAGRGLIAVNDGLHLILTTKFLLHRLFVRNGTTAVGYLKLLQLFDEVSYRTCWGESLDSHYSRTAPNDNTTELLPLDSFTRSNFNEICTWKTGFYTFYLPVACGIAIAGTTDEASYSAASHILLKLGRYFQAQQNYGRRDPVAQSAVREVYEQLRLRQIFADYEAQMRTEIMGDITDWTLPDACVTRHAQHLFCDLVDLLFRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX60</accession>
    <name>A0A074ZX60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164204.1">
        <property type="nucleotide sequence ID" value="XM_009165940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX60"/>
    <dbReference type="GeneID" id="20316018"/>
    <dbReference type="KEGG" id="ovi:T265_01830"/>
    <dbReference type="CTD" id="20316018"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704409" evidence="2">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7042" checksum="2A1232E868C99EE5" modified="2014-10-01" version="1">MAWDGMVVLGLVSNVCFVVVVECGRGRGVPCSAPDPSAGRPRCPPPGSPLVAPLHPSEEDYPKTARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXH4</accession>
    <name>A0A074ZXH4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165656.1">
        <property type="nucleotide sequence ID" value="XM_009167392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXH4"/>
    <dbReference type="GeneID" id="20327309"/>
    <dbReference type="KEGG" id="ovi:T265_13141"/>
    <dbReference type="CTD" id="20327309"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="265"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="585" mass="64132" checksum="947A2EDF2E3F6801" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXT4</accession>
    <name>A0A074ZXT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164387.1">
        <property type="nucleotide sequence ID" value="XM_009166123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXT4"/>
    <dbReference type="STRING" id="6198.A0A074ZXT4"/>
    <dbReference type="GeneID" id="20316173"/>
    <dbReference type="KEGG" id="ovi:T265_01985"/>
    <dbReference type="CTD" id="20316173"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="446" mass="50350" checksum="B1A31A145A6335CA" modified="2014-10-01" version="1">MNQSLPLCMDFQLWNDSVNTSVAINQDWLAWFGVSFGKLHGPLSLAVCAFGISTNLTNIVVLTRPALANSATNQLLLCLAVADLITMLIYVPGLCHFYIAQPTPMKSPIYSPSKSWVTYQTGAASGVIVFHSVAIWITVILAVFRYIHIGFPSVGPRIATKRRAMTSVFIAIVICFVIVIPNTLINYVDSCLGPGDNIQRLRVYYFVNVPSLDESTESCWKQFHTQCMLVFNFWSQATVYKILPCFLLATLTVLLIYELRLATRRRKKLHCLRERTHGQTLLSDCQRPQMPQSKRNDERNQQYNENRTTSLLLTILIFFLVVEMPQGVLVICLHLIPDFYERVYRHLGDFIDFTTLVNEAINFVIYTTMSQQFRLTFCKVFYIKRIKCWTAGNSSRHAPVSSAVNRAKAGENAKSECLVIGAHDPYTSSAVPCRLTETSVAANMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXY8</accession>
    <name>A0A074ZXY8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_11300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597098">
        <property type="protein sequence ID" value="KER20059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176186.1">
        <property type="nucleotide sequence ID" value="XM_009177922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXY8"/>
    <dbReference type="STRING" id="6198.A0A074ZXY8"/>
    <dbReference type="GeneID" id="20325468"/>
    <dbReference type="KEGG" id="ovi:T265_11300"/>
    <dbReference type="CTD" id="20325468"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000128">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="159" mass="18773" checksum="E47CC539D10A7A3D" modified="2014-10-01" version="1">MPRDKALCDILDSAFYKSPYRDRRNDASSKQLQRALRQSTTLYVGNLSFYTREEQIWELFSRAGEIKRVIMGLHRFHKTPCGFCFVEYMTREGAEMAMRYVNRTRLDDRVIRTDWDAGFENGRQYGRGRTGGQVRDEFRKDYDADRGGYGRLAQREIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY05</accession>
    <name>A0A074ZY05_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168062.1">
        <property type="nucleotide sequence ID" value="XM_009169798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY05"/>
    <dbReference type="GeneID" id="20319112"/>
    <dbReference type="KEGG" id="ovi:T265_04930"/>
    <dbReference type="CTD" id="20319112"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="15829" checksum="A211F220186DABC9" modified="2014-10-01" version="1">MKKLGRKFLGEGRHIRGENYPRNKPCSLDAMRYNGMLISNEIRTIIFTTAFNRALLNEYTKLVKSTDTALASAPKMLAPLLDDCSLSETKIYGENFYRNTGIQNIPSGDVRAVSGWSSSANLTPNSGPDEMQAHLSFPYFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYH8</accession>
    <name>A0A074ZYH8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597079">
        <property type="protein sequence ID" value="KER20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176049.1">
        <property type="nucleotide sequence ID" value="XM_009177785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYH8"/>
    <dbReference type="GeneID" id="20325358"/>
    <dbReference type="KEGG" id="ovi:T265_11190"/>
    <dbReference type="CTD" id="20325358"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="249" mass="29021" checksum="94F51BA05832E078" modified="2014-10-01" version="1">MDTRGISSGEHSESRIRSMQQNPSKGQVFNDYEHEDVYKGVIIDYLGKMLSFELIQIFLFVMRQLDAAEFNEILFYMYKIKMHKPMMVYIDACKSDSMFQDILPSNVAITDERLNTSRRPELEAISGTQLRDWYYTSKDPPKITAVWADLTEVNGNWWYSNDIDREKKYKKPVIYMDACYSGSMFRSLLPSDVRILPRIRFNTVFKLNARCDSELPCTKISSPDVNAIFSQSSAFDPECESNTVKYWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYU1</accession>
    <name>A0A074ZYU1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175910.1">
        <property type="nucleotide sequence ID" value="XM_009177646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYU1"/>
    <dbReference type="STRING" id="6198.A0A074ZYU1"/>
    <dbReference type="GeneID" id="20329506"/>
    <dbReference type="KEGG" id="ovi:T265_15341"/>
    <dbReference type="CTD" id="20329506"/>
    <dbReference type="OrthoDB" id="9439254at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="151"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="254" mass="29279" checksum="068AE9B3C67B03B7" modified="2014-10-01" version="1" fragment="single">DESDWPSSGEEWTPNLLLGSKKKKDTSQECEPMNKKKMSSFDPSVTKQTANRGLVMELATSEAARRYPIRERPRPNYSVTTPIPEDDRFLYCYDCDSSILDGCLIHPVEWVENKPLSVCEEAKGRDVQFQKEKCVCGIAYYLHTARTAPRDWIYIYKSGIPGAGFGVWTNREIKRGTTFGPYAGEVVYLDEMREEELVRRSRGGYAWLVRQNLQGMKSHLVDARNPVQSNWLRFVNCARFDEEQNLVTIQYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYU5</accession>
    <name>A0A074ZYU5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597064">
        <property type="protein sequence ID" value="KER20359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175893.1">
        <property type="nucleotide sequence ID" value="XM_009177629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYU5"/>
    <dbReference type="GeneID" id="20325245"/>
    <dbReference type="KEGG" id="ovi:T265_11077"/>
    <dbReference type="CTD" id="20325245"/>
    <dbReference type="OrthoDB" id="6246981at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48460" checksum="ADDF6BE9CC10E672" modified="2014-10-01" version="1">MVRELLVFANDAIYEDCWVFALEHKIAMGYCQVLGTSGLVSFLLTMPTVMFGLLSGIALVAAVGRNTVWRAKLRLYAVTQFIIDFLFSTVVGIMHLFLCYGLPWLSYGGVYLHKNSDLDCRIVHFLYSLSFSAMSTLLLASTLDFVLSVRFDGQASPTSTRTVVFGSILLAIVFALPDLAVCSLWNLDGRIYCSTSATLPRIVILLAELHQFFLVHGSSQCISTFVLLGILSKTTKSLDITVSLLYGASQIKDNVCNAAYEASEVTRHLKEKANFILVRSALMGTTLLLRALLCLYLDNRLYFLQEERRSDARTILYTFTGVKHILDYMVILASIFHYWLYYFNFECLRNDPLRSKTSDQDGLVMPVHPNPRASLVRLRQLITFVCKFDYDLCKQLQSLQPAISKTTVRRLDREEAVRSHLLLRKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ28</accession>
    <name>A0A074ZZ28_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163887.1">
        <property type="nucleotide sequence ID" value="XM_009165623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ28"/>
    <dbReference type="STRING" id="6198.A0A074ZZ28"/>
    <dbReference type="GeneID" id="20315752"/>
    <dbReference type="KEGG" id="ovi:T265_01564"/>
    <dbReference type="CTD" id="20315752"/>
    <dbReference type="OrthoDB" id="6252462at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20934" checksum="33CD93672AAC6085" modified="2014-10-01" version="1">MFLTCIRIEGRSEGIAGETLTLTCVTEVRGVSKSANLVWSHGTGAHRTYISPSLTTFDTALILRDPKSSQTYNDSHLKPAIQTAVSRRVRITEKHHANHTIHSQLTFQPLLSEHAGLWKCVKIGHPLRTIIEEAETMVYVRSKVLPASTRQVGRNDNSDKNPSRGRKSYPNIVMIIVARFALGMLFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A046</accession>
    <name>A0A075A046_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597022">
        <property type="protein sequence ID" value="KER20779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175479.1">
        <property type="nucleotide sequence ID" value="XM_009177215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A046"/>
    <dbReference type="STRING" id="6198.A0A075A046"/>
    <dbReference type="GeneID" id="20324918"/>
    <dbReference type="KEGG" id="ovi:T265_10750"/>
    <dbReference type="CTD" id="20324918"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12587" checksum="BB42CCDF397C1850" modified="2014-10-01" version="1">MGFPENGDLIIVTERQNQTDICTLARICGHAQGVQIVMHGPTVTVEFQSNGDLFKGQGFQASYEFVHRTQVQSSPYLSAASQFLEERQQRDHSYINPWAADDNSPQIGQSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A074</accession>
    <name>A0A075A074_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_01001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163180.1">
        <property type="nucleotide sequence ID" value="XM_009164916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A074"/>
    <dbReference type="GeneID" id="20315189"/>
    <dbReference type="KEGG" id="ovi:T265_01001"/>
    <dbReference type="CTD" id="20315189"/>
    <dbReference type="OrthoDB" id="5869902at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039888">
        <property type="entry name" value="Melted-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630:SF10">
        <property type="entry name" value="VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21630">
        <property type="entry name" value="VEPH-A/MELTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126695" checksum="278326AAF2A086FD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1K0</accession>
    <name>A0A075A1K0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163112.1">
        <property type="nucleotide sequence ID" value="XM_009164848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1K0"/>
    <dbReference type="STRING" id="6198.A0A075A1K0"/>
    <dbReference type="GeneID" id="20326834"/>
    <dbReference type="KEGG" id="ovi:T265_12666"/>
    <dbReference type="CTD" id="20326834"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37034" checksum="661E110C57FF77E6" modified="2014-10-01" version="1" fragment="single">EVDIIIRTSSNTLLSETWVSGKVVLCTNSRRRNGIFKVIPDCPHTIGVEFATKIIELDDQKIKLQIWDTAGQERFRAVTRSYYRGAAGALLVYDITRKSTFNRIHTWLSDARRLTCHNTVVFLIGNKADLEEQRDVSYEEAKQLADENDLMFLECSAKSGTNVDDVFIETARKIYQNVQEGNVNLNSAEGGILSKGSIGSGNWLEREFTDRKVRGSNPTSASRLPLARLQQPGSIPALVSPSCGMAARHRKGATAERFASSNFQTQNTPLISTPYTIHLRIDQLCPSPPSDLFVRTFDEFWVGTEIRSRTSKVCVTPKADSRDTSVGLENIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1S2</accession>
    <name>A0A075A1S2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_15113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596973">
        <property type="protein sequence ID" value="KER21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174905.1">
        <property type="nucleotide sequence ID" value="XM_009176641.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A1S2"/>
    <dbReference type="GeneID" id="20329278"/>
    <dbReference type="KEGG" id="ovi:T265_15113"/>
    <dbReference type="CTD" id="20329278"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="943"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1683" mass="185626" checksum="7176EC8BC077B5C3" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1T6</accession>
    <name>A0A075A1T6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166749.1">
        <property type="nucleotide sequence ID" value="XM_009168485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1T6"/>
    <dbReference type="GeneID" id="20318080"/>
    <dbReference type="KEGG" id="ovi:T265_03893"/>
    <dbReference type="CTD" id="20318080"/>
    <dbReference type="OrthoDB" id="6241320at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138868" checksum="B4B91A8C94534B18" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A239</accession>
    <name>A0A075A239_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162851.1">
        <property type="nucleotide sequence ID" value="XM_009164587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A239"/>
    <dbReference type="GeneID" id="20314926"/>
    <dbReference type="KEGG" id="ovi:T265_00738"/>
    <dbReference type="CTD" id="20314926"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="20908" checksum="96003F5331119E8C" modified="2014-10-01" version="1">MLVDVQSLNTPLTIQGEALEVVERFTYLGSCINSDCSVTEEVGCLLVDPETGSPGSSKEADNDRAPGGIPFTAPKLENHASIFALFFRWTITRGACGPQRVAGIAFLAAIRSVDLNDIQCSFSQAWGPGQTVLKTESIVSLTRVHIAFRQSSSYACLLGQPDNIPSILLSSGGMTVRHRKDATAERFLVTPRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2C0</accession>
    <name>A0A075A2C0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_10168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596959">
        <property type="protein sequence ID" value="KER21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174721.1">
        <property type="nucleotide sequence ID" value="XM_009176457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2C0"/>
    <dbReference type="STRING" id="6198.A0A075A2C0"/>
    <dbReference type="GeneID" id="20324336"/>
    <dbReference type="KEGG" id="ovi:T265_10168"/>
    <dbReference type="CTD" id="20324336"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER21544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="828" mass="94064" checksum="194455257A97B7C0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A668</accession>
    <name>A0A075A668_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_12502</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162402.1">
        <property type="nucleotide sequence ID" value="XM_009164138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A668"/>
    <dbReference type="STRING" id="6198.A0A075A668"/>
    <dbReference type="GeneID" id="20326670"/>
    <dbReference type="KEGG" id="ovi:T265_12502"/>
    <dbReference type="CTD" id="20326670"/>
    <dbReference type="OrthoDB" id="5600418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="600" mass="66911" checksum="3985D499C327D82E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA22</accession>
    <name>A0A075AA22_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163565.1">
        <property type="nucleotide sequence ID" value="XM_009165301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA22"/>
    <dbReference type="STRING" id="6198.A0A075AA22"/>
    <dbReference type="GeneID" id="20315483"/>
    <dbReference type="KEGG" id="ovi:T265_01295"/>
    <dbReference type="CTD" id="20315483"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="568" mass="63301" checksum="4E48772483C00E82" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAT5</accession>
    <name>A0A075AAT5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163228.1">
        <property type="nucleotide sequence ID" value="XM_009164964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAT5"/>
    <dbReference type="GeneID" id="20315209"/>
    <dbReference type="KEGG" id="ovi:T265_01021"/>
    <dbReference type="CTD" id="20315209"/>
    <dbReference type="OrthoDB" id="6277134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="20609" checksum="7BB7120254718529" modified="2014-10-01" version="1">MLILRPTANPLDGTLDGENSGNPEVTSGSTKEFQCDLVPLDAAKSLNGKWKATVDPVGAATVTELEDGSSAKIGPPNSQGYQNQPSSFKVSCAFSTPEGTPIYTFERTVAVKRASPEILIGGAITRHSRGSERNIAGSADGARSRVGVDSPFPVMRALGETDISQKNAILNVTQRLNSHSIWVDAKPIRMRQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC02</accession>
    <name>A0A075AC02_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162827.1">
        <property type="nucleotide sequence ID" value="XM_009164563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC02"/>
    <dbReference type="GeneID" id="20314902"/>
    <dbReference type="KEGG" id="ovi:T265_00714"/>
    <dbReference type="CTD" id="20314902"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="350" mass="39110" checksum="5A919E4A6E0A504A" modified="2014-10-01" version="1">MKKQTGLLFLILGHTPNKVAFWAAGPLHTLAYQSSGVVDKFIYTDGRISSFEPIVDRIASRIMASVVVSKRGNWQPITYLRDRSRYCRESVELIARRNLVNELLTRRSRVSIKSEACWISQELEGVCLNLDLDNGFPPPVGGDFMTCKVCKKIYYKNLKILAALSQNTNCKAVGPRRGRGESVELIARRNLVNELLTRRSRVSIKSEACWISQELEGVCLNLDLDNGFPPPVGGDFMTCKALQFPDQDGIPSLILGAGGPDISTFILGLLRIPLITDTITSRRRHSTIVLHCKSGPQTASSSYRGIHRTYLPPRTLELLIKVPVMDNLLTTKTLNNRQYAFMARRSANTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACQ8</accession>
    <name>A0A075ACQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162466.1">
        <property type="nucleotide sequence ID" value="XM_009164202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACQ8"/>
    <dbReference type="STRING" id="6198.A0A075ACQ8"/>
    <dbReference type="GeneID" id="20314617"/>
    <dbReference type="KEGG" id="ovi:T265_00429"/>
    <dbReference type="CTD" id="20314617"/>
    <dbReference type="OrthoDB" id="6234629at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="130" mass="15083" checksum="FFA58EAC08C561A6" modified="2014-10-01" version="1">MLQQEQTLHLSKKDSSGSVGLLWLKRTYEFLIRTLWHLSQSTSADSMYDIIIKAYDETLTKHHNRLMRHTFKLILHSLPKRSAFIKKLAYDHDGCERQVLSGAANCVKMLQPIVAKLNELLLEFQLEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEX1</accession>
    <name>A0A075AEX1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596730">
        <property type="protein sequence ID" value="KER27144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169129.1">
        <property type="nucleotide sequence ID" value="XM_009170865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEX1"/>
    <dbReference type="STRING" id="6198.A0A075AEX1"/>
    <dbReference type="GeneID" id="20328019"/>
    <dbReference type="KEGG" id="ovi:T265_13852"/>
    <dbReference type="CTD" id="20328019"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21352" checksum="EDD89F0B15FD2BD2" modified="2014-10-01" version="1">MAICLNELNPQKLVQKAFAILRIIRRTFSRITLMDFQILYGAYVRPLLEYANQVVYSGRTKDVTLIERSRQAATRMVVGLKSVDYETRLAMLDLFPRTAACLISFPWSTAASGGTLFLLTPCLNKAWQTCFLPLTQQTPGGDIVRKFSSSEHTFIRQIFFSFRLLRAMTFLQQLFTLLPEPSLKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF20</accession>
    <name>A0A075AF20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168933.1">
        <property type="nucleotide sequence ID" value="XM_009170669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF20"/>
    <dbReference type="GeneID" id="20319792"/>
    <dbReference type="KEGG" id="ovi:T265_05610"/>
    <dbReference type="CTD" id="20319792"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9899" checksum="D6FFE0FFADCC8255" modified="2014-10-01" version="1">MTKRATRKQIATCVFLIPKCDNGMEITHLKESAREGDFLFTSYFSPFMFIATDVFAKRTQPDPRFAPDSDSSESACIMWTQLLLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF79</accession>
    <name>A0A075AF79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168776.1">
        <property type="nucleotide sequence ID" value="XM_009170512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF79"/>
    <dbReference type="STRING" id="6198.A0A075AF79"/>
    <dbReference type="GeneID" id="20319672"/>
    <dbReference type="KEGG" id="ovi:T265_05490"/>
    <dbReference type="CTD" id="20319672"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="491" mass="52835" checksum="D613BDE9CE79DA85" modified="2014-10-01" version="1">MNLTVANSGEGSFITSLEGRQCIEYLARIKATKEQCKVVANTATHSIMQSKADHKEASSGASAVRRRGRNQNSVKSIAKKSEPDTDSSTTTNTSVKPQQYSKESREWELTKLRSFTLPFPLPDSPDVNGVQVKASDGSGLPTCVATGGPGGCWLAVGSDVGSVFLINRHVDPERNIVEPASRSHQLKTAHWLRRKVTDRKALTSASRLFLSRLGKPGSISALVLPLGEMATRHLKDATSKPSNLSTMAQCLERKFTDWKVHAPNPTSESQLLLSGLGHPGSVRPLASIIYPDVSGGLSSGVCSLALTSSQAPVGTKASSNHPAPLLATICDQPSWGALRVWRTDPTQGDDDCPLFESIPPGAQIRDRRCKKKKPTQHNHIDSTASLTDDLFAEDNHCGTCRVRLQPYALASCSIFTSGITPPPSPTTHSVTANSVSCPLYRPAVTPFRRLTAMSPKGSTRVGCPSLDEGGRETFVGFESRTFRSVNSRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFM6</accession>
    <name>A0A075AFM6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDA1/CD39 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168317.1">
        <property type="nucleotide sequence ID" value="XM_009170053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFM6"/>
    <dbReference type="STRING" id="6198.A0A075AFM6"/>
    <dbReference type="GeneID" id="20319311"/>
    <dbReference type="KEGG" id="ovi:T265_05129"/>
    <dbReference type="CTD" id="20319311"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55541" checksum="1C974C3D720EC3BC" modified="2014-10-01" version="1">MRPFAHRKIEERPSTDMLLRDLLICILQMTVAHALVIPGDMKYVVIVDAGSSGSRVYVYTWRDGSGLKSPELLKDEFGRPVVKKTSPGLSSFAHNPKDARKHIDDLLDFAESAIPKSYLSGTHVYVFATAGMRLLSAKYQCLIWRNVRSEIRSRYSFEFANTDARTISGDEEALFGWIAVNYLLQRFDRDEYEKQRKSTYGMLDLGGASMQIAFELEPKTRNSTNVFPLSLRTKSSEDYGSSLQSYALFLHSYLSYGANFMRKRHEEVLLFKHLPPWADPEKPVTIADPCLQKGLTISTTLSPKKPNDTESLRENEEEKKYQVELVGEGDPDKCKVLVRELVLGGEMGKGPSPPIGFEMPFYGLSEFVYALEGVSSKEIYLYSEAEPKIEELCRRPWEEYTKILREQYGDEETYKKFLKIKMHHCFKAIYVVTVLHDGFKFPKTYDKLHRVNEINGTDVQWSLGAIFFILNSEDGQANQESRQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH33</accession>
    <name>A0A075AH33_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RUS1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166960.1">
        <property type="nucleotide sequence ID" value="XM_009168696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH33"/>
    <dbReference type="GeneID" id="20318247"/>
    <dbReference type="KEGG" id="ovi:T265_04061"/>
    <dbReference type="CTD" id="20318247"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="42"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="279"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50048" checksum="FB3BF9FAEE594B89" modified="2014-10-01" version="1">MFDRRLALETYGDGHSLRIAVPSRENPFFLWRTIRYYISTLTFKKIFLPKGYPNSVSPDYLEYQIWDTVQALASSVTGALAAQSVLIGVGVGDVKATILGASLSWMLKDGSGMIGKIVFVGWQGLLADIINDCALFLELASSFFPSVFTFIICVANLCKSVVSVAGGATRAAVTLHQALDNNVADVAAKDGSQETLSNLLALFFNLSVVYFVTGNWSVIWTGFIILTFIHVYANYRAVQCLRLSTFNRNRFHIAVQQWLRQRLFHGPSVSESTAIPFPSIEWVNSREPILFPASNARIHLGCSLQTLPNKEQYNLKDLINVFSQEKYLLYCPNWRATSHSPNSSPLTIHIVLVHGCQLMDQLMSMLHAELLVFLNKLPLNFYPTEEVKKIRQSKTVTEFSQMTLEWTKLLSGKLIQDISTSPAPRWNLDSLHFSADEWRCTWTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHA2</accession>
    <name>A0A075AHA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_03833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCMBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166678.1">
        <property type="nucleotide sequence ID" value="XM_009168414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHA2"/>
    <dbReference type="STRING" id="6198.A0A075AHA2"/>
    <dbReference type="GeneID" id="20318020"/>
    <dbReference type="KEGG" id="ovi:T265_03833"/>
    <dbReference type="CTD" id="20318020"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="557" mass="62624" checksum="FA41E64A5CFAF8F7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHG3</accession>
    <name>A0A075AHG3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166427.1">
        <property type="nucleotide sequence ID" value="XM_009168163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHG3"/>
    <dbReference type="GeneID" id="20317815"/>
    <dbReference type="KEGG" id="ovi:T265_03628"/>
    <dbReference type="CTD" id="20317815"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12502" checksum="47B32EFC3B0BB437" modified="2014-10-01" version="1">MEYQYEAYHKEEMISGIESGSGKLDTGRPLDRTRCGLRPTENARCPHYKATAIASACLDQSQYFFKDMVNDPSDAGTHFQCEQHWFVRFTREIDPGKVGSTRNVLFMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHJ4</accession>
    <name>A0A075AHJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166236.1">
        <property type="nucleotide sequence ID" value="XM_009167972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHJ4"/>
    <dbReference type="GeneID" id="20317659"/>
    <dbReference type="KEGG" id="ovi:T265_03472"/>
    <dbReference type="CTD" id="20317659"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13587" checksum="5E0A81249C9D6B9C" modified="2014-10-01" version="1">MLISRTANRYSVSWLQSEDKIFSGVLLKADFEFRMAQKFASSQRWGRSICLQKKTGHPSSPQRVSLKFPGYSLTPIISRSNPSKCSKATPQIPQQISPFQETQSEIPRTTHTTRVRPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHM4</accession>
    <name>A0A075AHM4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166131.1">
        <property type="nucleotide sequence ID" value="XM_009167867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHM4"/>
    <dbReference type="GeneID" id="20317585"/>
    <dbReference type="KEGG" id="ovi:T265_03398"/>
    <dbReference type="CTD" id="20317585"/>
    <dbReference type="OrthoDB" id="10600925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="11811" checksum="E3C8EF6F15C2B480" modified="2014-10-01" version="1">MLPARSMIFCTADGEEKVTVNDSHRQTRTKATRETWAKASILCIHPLIRELNVTLCIKTGLARWCFYWCGFICKSSSGDSFCLSFVSTTLGGAGILVEVSNAALFGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIH4</accession>
    <name>A0A075AIH4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164632.1">
        <property type="nucleotide sequence ID" value="XM_009166368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIH4"/>
    <dbReference type="STRING" id="6198.A0A075AIH4"/>
    <dbReference type="GeneID" id="20327102"/>
    <dbReference type="KEGG" id="ovi:T265_12934"/>
    <dbReference type="CTD" id="20327102"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17315" checksum="2D5F9E67850C37C0" modified="2014-10-01" version="1" fragment="single">MKFTELMEHEQEEIKKGVRFFDPANTGSVATADLGKILRWCKLIPTNAEISALAEQLDPSRTGRISLPFVYNAVANMWPSYPGELERRAWGAFLTFDKCDKGKITPEDLSKILLGFGLEPLPENEVKKIIKESIDRKDGLIEYGMLIREWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIH9</accession>
    <name>A0A075AIH9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164607.1">
        <property type="nucleotide sequence ID" value="XM_009166343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIH9"/>
    <dbReference type="STRING" id="6198.A0A075AIH9"/>
    <dbReference type="GeneID" id="20316357"/>
    <dbReference type="KEGG" id="ovi:T265_02169"/>
    <dbReference type="CTD" id="20316357"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7786" checksum="EFE882907E112B74" modified="2014-10-01" version="1">MGRASAVNLLDIARCYATMKKGAQAKKYLDECLASIDEGREIEQLRRTAIVQQHRSELARKLFTLNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ02</accession>
    <name>A0A075AJ02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163696.1">
        <property type="nucleotide sequence ID" value="XM_009165432.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AJ02"/>
    <dbReference type="GeneID" id="20315594"/>
    <dbReference type="KEGG" id="ovi:T265_01406"/>
    <dbReference type="CTD" id="20315594"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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</entry>
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</entry>
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</entry>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z094</accession>
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        <submittedName>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20461.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z094"/>
    <dbReference type="GeneID" id="20325162"/>
    <dbReference type="KEGG" id="ovi:T265_10994"/>
    <dbReference type="CTD" id="20325162"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10586" checksum="D1CC1C6D883DCDF1" modified="2014-10-01" version="1">MQEPAGLLLRVTGIKKVETLKTGEKNMKLRARVGPLQHLHGTEQESVLEHVFSCVSLPRLAQYWRWFLKLRDYYNQYSRTKLISTQIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0B9</accession>
    <name>A0A074Z0B9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597480">
        <property type="protein sequence ID" value="KER18922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177331.1">
        <property type="nucleotide sequence ID" value="XM_009179067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0B9"/>
    <dbReference type="GeneID" id="20329915"/>
    <dbReference type="KEGG" id="ovi:T265_15750"/>
    <dbReference type="CTD" id="20329915"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="65" mass="7402" checksum="8193A4C6BD7BC859" modified="2014-10-01" version="1" fragment="single">MLRDLTRDFIGLVRTKELNYVSVDASSLYLLDSLESSFARSTSNNRLGYQTTAASDEQCDTRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1P2</accession>
    <name>A0A074Z1P2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597011">
        <property type="protein sequence ID" value="KER20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175359.1">
        <property type="nucleotide sequence ID" value="XM_009177095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1P2"/>
    <dbReference type="GeneID" id="20324820"/>
    <dbReference type="KEGG" id="ovi:T265_10652"/>
    <dbReference type="CTD" id="20324820"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11172" checksum="2AA8582AABFD78DB" modified="2014-10-01" version="1">MPLASLIAPPDEGVDRRATQCFSVPGGALPQAKFPALYEDMAISSQYEFTSDGGRIQKMVLLPSDLFASDAAQENVRRSDSGRVRGRKQQTSGSQLLIRTISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2K4</accession>
    <name>A0A074Z2K4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596987">
        <property type="protein sequence ID" value="KER21188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175077.1">
        <property type="nucleotide sequence ID" value="XM_009176813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2K4"/>
    <dbReference type="GeneID" id="20324607"/>
    <dbReference type="KEGG" id="ovi:T265_10439"/>
    <dbReference type="CTD" id="20324607"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6645" checksum="070A0D32098CC48D" modified="2014-10-01" version="1">MANKSASFHRNKLVRSTKMKDSMIVKEVVLLVGFVFQCKNTLQLIQVLVGVIELLAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2U3</accession>
    <name>A0A074Z2U3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KATNIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596977">
        <property type="protein sequence ID" value="KER21303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174954.1">
        <property type="nucleotide sequence ID" value="XM_009176690.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z2U3"/>
    <dbReference type="GeneID" id="20324513"/>
    <dbReference type="KEGG" id="ovi:T265_10345"/>
    <dbReference type="CTD" id="20324513"/>
    <dbReference type="OrthoDB" id="304622at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="3">
        <location>
            <begin position="562"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="3">
        <location>
            <begin position="809"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1330" mass="150520" checksum="7AFAA5E8015A6587" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z333</accession>
    <name>A0A074Z333_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596964">
        <property type="protein sequence ID" value="KER21476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174781.1">
        <property type="nucleotide sequence ID" value="XM_009176517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z333"/>
    <dbReference type="GeneID" id="20324378"/>
    <dbReference type="KEGG" id="ovi:T265_10210"/>
    <dbReference type="CTD" id="20324378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17023" checksum="529B194807FADC3E" modified="2014-10-01" version="1">MLRLGSNHGPSSPKFPDVGRYRRTAAMKVKGNMNAGILPTCPNLDGRNREARIGFKPGTLRLVVSRLNYLEVSGALPIVVGQKHWTQVSLLLELIRRAYPWLCRLLSPMSLAYGANVLPQLHRLTLEASEFSHMYMRTSSRFGMRLACPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z388</accession>
    <name>A0A074Z388_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596960">
        <property type="protein sequence ID" value="KER21526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174729.1">
        <property type="nucleotide sequence ID" value="XM_009176465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z388"/>
    <dbReference type="STRING" id="6198.A0A074Z388"/>
    <dbReference type="GeneID" id="20324340"/>
    <dbReference type="KEGG" id="ovi:T265_10172"/>
    <dbReference type="CTD" id="20324340"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34831" checksum="3CADA7B2FA75267C" modified="2014-10-01" version="1">MEQTVKHHTEHPKNFSFGQLIDMISTPATLKHLLRMVPDIMNGSATSHIRRQKFLDNFQNLVNFNRPSENFRKHLHSTFSTGTTVDQRGLDPMFGKPLNTIDTRIKSPLNSGAQVINDLNNAQNRLNFEFDPKLWCDTHFPSNFYDADGYVSGYYEQLNQVKKYCSKQLENTFWVTSYHVSGKVRNKLSFCFSQVKVWFQNRRTKFKRVRLDDKDEAEENAQHSTDAELPSPTQSVDDKLYGRKRHATNLIQEKSLQTCPLVKEASKLSGADSSPEKETTFRPAAPISGGKLNLHHRASSHTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z418</accession>
    <name>A0A074Z418_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596937">
        <property type="protein sequence ID" value="KER21831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174412.1">
        <property type="nucleotide sequence ID" value="XM_009176148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z418"/>
    <dbReference type="GeneID" id="20324095"/>
    <dbReference type="KEGG" id="ovi:T265_09927"/>
    <dbReference type="CTD" id="20324095"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="284" mass="31472" checksum="E3EE315FFEE094FC" modified="2014-10-01" version="1">MPFKEDEGAGSHEHLVRLPSLNSLFQWRPFQFRANSSDQKKGHQTTPYTKEMAHRSVSMQYLSDTQPQTPHLIHTRRGRLKANISLRLKSFLRGSELRVRSVESLLKQKQQHTHQETEASNVVLASTPGTLSSQNLAGSADSSGCDSFQQHENSRYYLGGNLHAGRPTAIRNSCSSFCDFSHLSPGTSGSLWNSQQLFSPLDKDAEEQEQDFIRKEPPAGVKIVAKRLLGHGANGICHEVSIQPLGHLANQGSSGLPERAALKVCGLFICLTYSSLFTARWLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z490</accession>
    <name>A0A074Z490_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174333.1">
        <property type="nucleotide sequence ID" value="XM_009176069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z490"/>
    <dbReference type="STRING" id="6198.A0A074Z490"/>
    <dbReference type="GeneID" id="20324034"/>
    <dbReference type="KEGG" id="ovi:T265_09866"/>
    <dbReference type="CTD" id="20324034"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15856">
        <property type="entry name" value="SNARE_SNAP29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="25600" checksum="A168A8EB9A870A5E" modified="2014-10-01" version="1">MPGNPFDEEEVGGFGSIGSTQNHRGTSWLGTEASVSGGSYSIQSQLSDSRARTQASQQRALASIASSERIGVETAAELLNQGEKLSHAERRLDDISQLQKDSQRQINTLSSVFGGIRNWFSRKPPAPVEPAPAPLPTPAPPTAFKSSLQAPSWGSQLPNNQMVSESATGDSDYERNLNLMSDGMSRLKGLAQGMNEELRAQNEQLDRMAPRINSINETMNKQNQQMNKLLGYKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4F6</accession>
    <name>A0A074Z4F6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597060">
        <property type="protein sequence ID" value="KER20412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175843.1">
        <property type="nucleotide sequence ID" value="XM_009177579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4F6"/>
    <dbReference type="STRING" id="6198.A0A074Z4F6"/>
    <dbReference type="GeneID" id="20325204"/>
    <dbReference type="KEGG" id="ovi:T265_11036"/>
    <dbReference type="CTD" id="20325204"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="39880" checksum="6A31F3BE65B4E1FB" modified="2014-10-01" version="1">MPFKLPYTSYSGDHFSLARMQVKSCTCVNTTRKYNCQYGISNKRKHAKLIYVELDKKKKLGAFSFILQLQTVNIWHHLSTVNHTTRSFILHLDDIRSQMRLREANSHDQTAVVNVADESTSRSQVAASFARLGLTSDSPYHVAIQIRVSAASEHCLGEIGPESNWFVVPLSPSKNILHQRWWFLLLLAFCATLTIIGLGFLFYTSVKRQNLHNSRYLARKFSGHIASDKLPDCCMSFEPCPMTTTHANVNGHRGNEKANSLEFPLLLSERYVQPSAHCMYTSFVGSCARSPRISELQQSPMEPWMSSPPPWDTGTLQTVDLLGLDESPNNSRHSLEFAGECVNAPITARDPCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5B1</accession>
    <name>A0A074Z5B1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596908">
        <property type="protein sequence ID" value="KER22263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173988.1">
        <property type="nucleotide sequence ID" value="XM_009175724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5B1"/>
    <dbReference type="GeneID" id="20329061"/>
    <dbReference type="KEGG" id="ovi:T265_14895"/>
    <dbReference type="CTD" id="20329061"/>
    <dbReference type="OrthoDB" id="6281746at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23683" checksum="277F8C64FBAAE41D" modified="2014-10-01" version="1" fragment="single">LPHARFSLYYDDETQDLYPERPLLFNSVSAAFTTVFTASSTRLSCVLVGTGSGKQSGSYRLLTEVTRLSTDFLVDTYSGTRSTHPGLGRRLSQFFRRLILMFLMTGHEQFATLGTENDTRHKMDSTGTSITPIYETVPRSPFSVSKTEGIVLGLLIFYFLGTVVTGVICWLCARRRLLKKRRKLRRPVSPHFEIGPNQLHIKYTDEDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z669</accession>
    <name>A0A074Z669_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598302">
        <property type="protein sequence ID" value="KER18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177523.1">
        <property type="nucleotide sequence ID" value="XM_009179259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z669"/>
    <dbReference type="GeneID" id="20330027"/>
    <dbReference type="KEGG" id="ovi:T265_15862"/>
    <dbReference type="CTD" id="20330027"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17807" checksum="E488C6AC9638FF7D" modified="2014-10-01" version="1" fragment="single">MNIRVLVETITVRHDGEFCRPTESPQLEFDVSNGASMGRNSLSGKGRSEDELWLVDVGTWLQQAALNVHLHHDILCTIRRKSRAARFDSATQIKLRERCWRFDVQNMLRLIYNGTPNYGRVIRYPRGPDLGPDVRCVQRVPPGHNDANILVLTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z675</accession>
    <name>A0A074Z675_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596997">
        <property type="protein sequence ID" value="KER21057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175185.1">
        <property type="nucleotide sequence ID" value="XM_009176921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z675"/>
    <dbReference type="STRING" id="6198.A0A074Z675"/>
    <dbReference type="GeneID" id="20329338"/>
    <dbReference type="KEGG" id="ovi:T265_15173"/>
    <dbReference type="CTD" id="20329338"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703817" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="322" mass="35433" checksum="D249729E648D3C50" modified="2014-10-01" version="1">MIPQWTLFVLLEVAAGSSIRVDKRIINGYDAKTGDHPWAVSIKGIHPTTLSITYCGATIIAEQWLLTAAHCFWTDARRKSMLNPGYWHAQAGHTKIVLGEEHTKREIIVGASDTDETGSNFLQNLFESLKKLILFKTSTDEAVADDKLWHVHFQKIILHPKYAPNDLEYDIALVKLRAALPIDGKKLAAAKLPAGLTTGDWPPVGTQCTFVGWGCQKYQGEPTANLQVVALRVVSHDACTEMYNHGAGLNEHHEFCAGYYQSNVGICAGDSGGGLIQMYERQVVVVGVASATHARQPQSYPGLFTRVSAFTDWIEKTVDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6B6</accession>
    <name>A0A074Z6B6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596888">
        <property type="protein sequence ID" value="KER22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173621.1">
        <property type="nucleotide sequence ID" value="XM_009175357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6B6"/>
    <dbReference type="GeneID" id="20323497"/>
    <dbReference type="KEGG" id="ovi:T265_09324"/>
    <dbReference type="CTD" id="20323497"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23018" checksum="BF41CF19D018B92B" modified="2014-10-01" version="1">MVTENRVASENNPWAAEINLVSTRDPAESPVSYDILQLNVLHTGHLMFPLALCSVYRTESTLTTYVICRKLFTKLIPFTLWKKNRSAVTPIRRLAPMLPEGCTRAGILPGCLSLDRGSQEAEVEFEPQVFRSLNSCSNHLGHLAPTLWSPYKMLQLDCLQTRTATLLLKILRQPTTGSALLETQEVGILREFSSTPCSTRTITART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z796</accession>
    <name>A0A074Z796_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174789.1">
        <property type="nucleotide sequence ID" value="XM_009176525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20324384"/>
    <dbReference type="KEGG" id="ovi:T265_10216"/>
    <dbReference type="CTD" id="20324384"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="443" mass="50880" checksum="848C92D021D81637" modified="2014-10-01" version="1">MNVSHPAVHFGPCAKECYSRFSHFCLRVLAPDSPTLDLPPLSHHQISSAWVKFSAAEQRTHQNSSSCFLPRVLLSLLDGEARDIVRDKHILKDGVTEDVFERLCACLIERIHPVEHQYRFQSRIQLSGERMSNFVRKLRRIIEDAFPDGTTSXLLSLLDGEARDIARDEHILRDGITEDVFERLRACLTERIHPVEHHYRYPSRIQLSGERLSNFVPELRRISEDAFPGLTDGQWEEKILKQIVVGTRASKLRERFLGSPPHSVAAALQVANQDILGVLQRNAAHLAPVHIQQQQQHSRRWTPAQGRPYHPMPLRPNRPYFHSTFQRPAPTKLSRWPIPNRDCPYCQRFGTHARTCGHNGPRDFTHFRCIPISTFDFLSTHQTPPVSSVMLTMKFPTFIIPPFVTPAPFLCLVCMYELAFVCPYHFTHLALRSSGHLYLTLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7Y4</accession>
    <name>A0A074Z7Y4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597236">
        <property type="protein sequence ID" value="KER19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176901.1">
        <property type="nucleotide sequence ID" value="XM_009178637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7Y4"/>
    <dbReference type="STRING" id="6198.A0A074Z7Y4"/>
    <dbReference type="GeneID" id="20326016"/>
    <dbReference type="KEGG" id="ovi:T265_11848"/>
    <dbReference type="CTD" id="20326016"/>
    <dbReference type="OrthoDB" id="6277907at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="473" mass="54118" checksum="BFBCC7D437F5B1CB" modified="2014-10-01" version="1">MTSTYGACSFLQLKACDFFNETLAFEDRIQSGHQLCDGLEVLILIFSMYFQSSSTDKEFPDLIHSVCERIQKFLSSTEPQILQESPIQQLRRICLEILQKVPNGDHVRPYARSILSLLFKLVEVENEENVLLCVKLIIDLHKYYRPSFSLDVTSFLSFVRRVYRGLQNEASNIFDPRSPIEVQSFDELEVGDVISKTFTITTIHTQEPKEDGTFKTYHILPKSCFSLKVMQEIPILVVLMYQLFKQHIHQDVSEFIPLIMDFINLKPTDVQRKNPRFDQDIFVDFMAAQVKTLSFLAYVIKIYQAFFSGKMARIRNHLAVAPFRYLTAMTSEGSTSARMLPGCLSLDRGVREAEDLVERHSANLVMGIMNLLYNCPPSVTNMRKEFFIAARHILSAPDIRPICFILQTTPITMLSSVVHVAVCAAHTRTTAADGAGYHPRVEYVLRNQMSVFWLPLLLFEFLRTCSENASSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9M3</accession>
    <name>A0A074Z9M3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597115">
        <property type="protein sequence ID" value="KER19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176298.1">
        <property type="nucleotide sequence ID" value="XM_009178034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9M3"/>
    <dbReference type="GeneID" id="20325561"/>
    <dbReference type="KEGG" id="ovi:T265_11393"/>
    <dbReference type="CTD" id="20325561"/>
    <dbReference type="OrthoDB" id="10296231at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="277" mass="32464" checksum="68CB69842128DB55" modified="2014-10-01" version="1">MPESNKAYIVLDQQHFQLENIDKQCSLELAYEMTTVLNPSGTFRILVSVLRLGLLTTYEQYRKIEEPLFMARGVTRFGLSTFDDVPMEMSSFLDYETFRLKYFNFFDDSPTLSISHFSNALKSITDYFQHRYELVYLHTSYTTMFRRCSKTDQEFPELIVYIQGCLVPTDFKNQLASLLDETSEVYQQTLGSVYKSLSDTMRAWKLEDCVSSLIVDPFMRKSEQYLTAIGHIGFDFIHLMKKIPNLFKENNLEKFVETYSKKPTVGIYKFRMKGNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9S5</accession>
    <name>A0A074Z9S5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM60A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597108">
        <property type="protein sequence ID" value="KER19995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176259.1">
        <property type="nucleotide sequence ID" value="XM_009177995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9S5"/>
    <dbReference type="STRING" id="6198.A0A074Z9S5"/>
    <dbReference type="GeneID" id="20325530"/>
    <dbReference type="KEGG" id="ovi:T265_11362"/>
    <dbReference type="CTD" id="20325530"/>
    <dbReference type="OrthoDB" id="10023333at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026065">
        <property type="entry name" value="FAM60A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422:SF12">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15396">
        <property type="entry name" value="FAM60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="71348" checksum="63282A4CA32B5712" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBE9</accession>
    <name>A0A074ZBE9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173334.1">
        <property type="nucleotide sequence ID" value="XM_009175070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBE9"/>
    <dbReference type="GeneID" id="20323264"/>
    <dbReference type="KEGG" id="ovi:T265_09085"/>
    <dbReference type="CTD" id="20323264"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="10379" checksum="F96A4982AE8FB766" modified="2014-10-01" version="1">MHLCATDRFVWSKNRRVDWRYELFVHSVPRRLQEARVGKRSNKKTALKFGSKDVVPLKMEDELLNTWKNSHSNVITSIAHGPEIMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCI9</accession>
    <name>A0A074ZCI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596854">
        <property type="protein sequence ID" value="KER23322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172924.1">
        <property type="nucleotide sequence ID" value="XM_009174660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCI9"/>
    <dbReference type="GeneID" id="20322947"/>
    <dbReference type="KEGG" id="ovi:T265_08768"/>
    <dbReference type="CTD" id="20322947"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="24897" checksum="E058695BAB5B98F3" modified="2014-10-01" version="1">MPPEERTKAGILIIIIIIDSMTSVLNTNASLPYSHDLFESLIVKKRIKLPPPSILAGILPGCPSLDRTSRDAEARFQSQTVATSCHPGWDTARMPKPRQDESRCRGKVPITDLPLESSWDISSLAKPTQGIQKADSGFKPGVLDQYTLLFSKNRGRSKVSFISVPSCHPTRKGKRVRILPDSPSLDRESREAEVGSEPRTLRSVNSQSNHLVHLAFQHRLATLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCM8</accession>
    <name>A0A074ZCM8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172893.1">
        <property type="nucleotide sequence ID" value="XM_009174629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCM8"/>
    <dbReference type="GeneID" id="20322923"/>
    <dbReference type="KEGG" id="ovi:T265_08744"/>
    <dbReference type="CTD" id="20322923"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="418" mass="47837" checksum="854D0D4315F973AF" modified="2014-10-01" version="1">MGMDQGEFVVRLLISNLGFVGTILNIIQLYVLCRCSISSRLTTLLLRTQSVVDAYTCFIIFIYKLAGMQIDTGLVVLDEVLCYLWSMDNLFWLGVVASVQNLTCISFDRFYAVCFPTKYKSHQTQLIFGCFLYEVAVTLFLFVPNFFLRRYQSNRCASAFAIDGPTTEQFFEVQSYLWMLLNYLLPAFIMISAHGYVVYVIRKPDVDQQTGQIARKNVRRLILTTSLMAGFLVVLHLYEAIRYILGSTGVVRTVMGSVAQQIGILFITLSAVLNPCLLYAGKWLRMFFISMFWTPAHLTQKKSTPTHVPNTENERKIRLPNDQLRQLSQSLRNAKYYGNKYSCFLRLINTVKEQHVMGSNHTGDSRDPHNKNNDLGRPNHFPTPAYTKLLCLQCSICMHARWLHKKASPLKFIAILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDY4</accession>
    <name>A0A074ZDY4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596832">
        <property type="protein sequence ID" value="KER23852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172406.1">
        <property type="nucleotide sequence ID" value="XM_009174142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDY4"/>
    <dbReference type="STRING" id="6198.A0A074ZDY4"/>
    <dbReference type="GeneID" id="20328712"/>
    <dbReference type="KEGG" id="ovi:T265_14546"/>
    <dbReference type="CTD" id="20328712"/>
    <dbReference type="OrthoDB" id="6285328at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12437" checksum="DBAFB98D20E6D666" modified="2014-10-01" version="1" fragment="single">MGSCASTGVSQVESPKRSLTVGSVNPAGAMSPSRTRASHNTAKGFDQNHLQHENQLNYADSLGTSVDLLVMGRGCLSRFARVCRHFFIHLLCFLRADNRTSEELFGVMLTLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEL8</accession>
    <name>A0A074ZEL8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596822">
        <property type="protein sequence ID" value="KER24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172138.1">
        <property type="nucleotide sequence ID" value="XM_009173874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20322333"/>
    <dbReference type="KEGG" id="ovi:T265_08154"/>
    <dbReference type="CTD" id="20322333"/>
    <dbReference type="OrthoDB" id="6263508at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05484">
        <property type="entry name" value="retropepsin_like_LTR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055510">
        <property type="entry name" value="DUF7083"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034128">
        <property type="entry name" value="K02A2.6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23309">
        <property type="entry name" value="DUF7083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="355"/>
            <end position="432"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="2464"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="3185"/>
            <end position="3213"/>
        </location>
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        <location>
            <begin position="497"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1629"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1823"/>
            <end position="1847"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1994"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2064"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2292"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2379"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2580"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2871"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2961"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3034"/>
            <end position="3104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3248"/>
            <end position="3295"/>
        </location>
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        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
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        <location>
            <begin position="641"/>
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            <begin position="695"/>
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        <location>
            <begin position="1155"/>
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            <begin position="1305"/>
            <end position="1316"/>
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        <location>
            <begin position="1658"/>
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            <begin position="2327"/>
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            <begin position="2393"/>
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        <location>
            <begin position="2604"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3350" mass="366985" checksum="6C6C5FE55E96CD11" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEV8</accession>
    <name>A0A074ZEV8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009172182.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20328307"/>
    <dbReference type="KEGG" id="ovi:T265_14141"/>
    <dbReference type="CTD" id="20328307"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15783" checksum="08529FB2B94695CA" modified="2014-10-01" version="1" fragment="single">MGYQLMVAENSSTNYDLFRPSWNSSGRRSPRIYVKLMFFLNSNCRNLTFETIYWSSELLRCHWTMEPSTSTSGEGDLCPSDRRGYIFIKKTTHEVAENTSTAHDRFRPSWGSSGWHSPRVSVNLMFYSESSQQPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFV2</accession>
    <name>A0A074ZFV2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KER22120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZFV2"/>
    <dbReference type="GeneID" id="20329107"/>
    <dbReference type="KEGG" id="ovi:T265_14941"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Semap_dom"/>
    </dbReference>
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        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="35703" checksum="5807D59E726BCEEE" modified="2014-10-01" version="1" fragment="single">STQVGLVAGFLDHQSPQSSSTTADYFVDQKKPWISRFCFSPTPTTHGSSSHPQNHPAWAAQMPVNQALHGWLSNSESSLWFGGHVQFHRVAAIGQKYFYVILTEDDVVSASVPTDSQSIFRTVRVTRIARLCQNDPGQGKAGEFLATNGVFSTFRKIRLQCRVDHSLVGVSADDNKSFVADHSPQLELTRALAVSELVPTDDGRDHVFYALMTTSDSITGILGICAFSLRSIDEALNRPQVFTWQTSDSDNWLQRFWRTVLPLTGWSSSSEDDFTYGTWSAYPTPGSSTLRMVGNTPMTEAISKSAEVSATFGFPILSFESPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG89</accession>
    <name>A0A074ZG89_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170031.1">
        <property type="nucleotide sequence ID" value="XM_009171767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG89"/>
    <dbReference type="GeneID" id="20320672"/>
    <dbReference type="KEGG" id="ovi:T265_06493"/>
    <dbReference type="CTD" id="20320672"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15090" checksum="12A9AF189487B6B4" modified="2014-10-01" version="1">MYTERLRQLEGVVVPSESAPRLHPDDGRNEENDKPGAQSDEASYSMRKIHQLSILFSSSRGLRICRFGNRIWQVRSNSIRLHTLPFSLLPVVSRCIQTQGFAFLWKGLGSVFIVRGLCFLSENILSEITSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGE5</accession>
    <name>A0A074ZGE5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169918.1">
        <property type="nucleotide sequence ID" value="XM_009171654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGE5"/>
    <dbReference type="GeneID" id="20320585"/>
    <dbReference type="KEGG" id="ovi:T265_06406"/>
    <dbReference type="CTD" id="20320585"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="49" mass="5534" checksum="D11FBEAA46CC43B7" modified="2014-10-01" version="1">MRSHVNVPQWSFLQNPQDFGLHQPTLADYQIQHDVIPDRTSAGVSTSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGT4</accession>
    <name>A0A074ZGT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_06339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169836.1">
        <property type="nucleotide sequence ID" value="XM_009171572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGT4"/>
    <dbReference type="STRING" id="6198.A0A074ZGT4"/>
    <dbReference type="GeneID" id="20320521"/>
    <dbReference type="KEGG" id="ovi:T265_06339"/>
    <dbReference type="CTD" id="20320521"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="457"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="459"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER26423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="758" mass="82789" checksum="2953BD7FFA1A4932" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP9</accession>
    <name>A0A074ZHP9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169435.1">
        <property type="nucleotide sequence ID" value="XM_009171171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP9"/>
    <dbReference type="STRING" id="6198.A0A074ZHP9"/>
    <dbReference type="GeneID" id="20320194"/>
    <dbReference type="KEGG" id="ovi:T265_06012"/>
    <dbReference type="CTD" id="20320194"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="170" mass="19136" checksum="DF9A55BC574E832B" modified="2014-10-01" version="1">MSRPTLTACSVTDLISGTFLFFLKFLICSARGLHSWITRVMYNRRSQLNPLWNTYIIGGLEQDGRPFLGFCDLQGVSFMDDCMASGFGAYFAIPLLRQRLEDLAGGDPKKLSEEQAIQAVTDAMRQLYYRDCRACNTYQLAIVRSTGAEVRGPLKLESDWSVAEYVSGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHU1</accession>
    <name>A0A074ZHU1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169400.1">
        <property type="nucleotide sequence ID" value="XM_009171136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHU1"/>
    <dbReference type="GeneID" id="20320166"/>
    <dbReference type="KEGG" id="ovi:T265_05984"/>
    <dbReference type="CTD" id="20320166"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7529" checksum="8A9AF813F45ED38F" modified="2014-10-01" version="1">MVSSDKSGPSRRPDNMENGQSSNVLSPEADSDDTQMKSPARSRTNANLLLQIGGVLGTGRHVVSILLGIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIA9</accession>
    <name>A0A074ZIA9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169514.1">
        <property type="nucleotide sequence ID" value="XM_009171250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIA9"/>
    <dbReference type="GeneID" id="20320254"/>
    <dbReference type="KEGG" id="ovi:T265_06072"/>
    <dbReference type="CTD" id="20320254"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="84509" checksum="5CF4CA96793FEE81" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIZ6</accession>
    <name>A0A074ZIZ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_05628</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168951.1">
        <property type="nucleotide sequence ID" value="XM_009170687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIZ6"/>
    <dbReference type="STRING" id="6198.A0A074ZIZ6"/>
    <dbReference type="GeneID" id="20319810"/>
    <dbReference type="KEGG" id="ovi:T265_05628"/>
    <dbReference type="CTD" id="20319810"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
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    </dbReference>
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        <property type="entry name" value="Mre11_DNA_bind"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
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            <begin position="351"/>
            <end position="577"/>
        </location>
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            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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            <end position="426"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="800"/>
        </location>
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            <position position="186"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
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        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER27303.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="815" mass="90672" checksum="140FDB11EA860D38" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ77</accession>
    <name>A0A074ZJ77_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">T265_05563</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER27388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="91" mass="9454" checksum="2E7FBEAE9D7AEDD7" modified="2014-10-01" version="1">MPQHRNANPAVMSSVMLGSQSYNSDQSNLGYPQSPSVPACQVGAGSQVPMQPGIAYQDFSGSFGKYAGIRRNVPSGLSAMQAAFSGRGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJJ7</accession>
    <name>A0A074ZJJ7_OPIVI</name>
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        <recommendedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 146</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">T265_05480</name>
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        <name type="scientific">Opisthorchis viverrini</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF34">
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    </dbReference>
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        <location>
            <begin position="845"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="247"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="322"/>
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        </location>
    </feature>
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        <location>
            <begin position="438"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="119707" checksum="A09BA4118764D977" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK28</accession>
    <name>A0A074ZK28_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170126.1">
        <property type="nucleotide sequence ID" value="XM_009171862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK28"/>
    <dbReference type="GeneID" id="20328230"/>
    <dbReference type="KEGG" id="ovi:T265_14064"/>
    <dbReference type="CTD" id="20328230"/>
    <dbReference type="OrthoDB" id="6236453at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="360" mass="39476" checksum="2531D9411F90514D" modified="2014-10-01" version="1">MVGTQVAPCTIVDATLSKPLLLRSISTPKSLLCSCGSPPHGQLSVEVVPSRLFTRSPDKLSSFVRHLVDGIEHIQMKNTSLFTNEMFSLQKNNGAWCNILFTNEQLTPFAHMWSALIRMNELFNSHSETCSTVKLCAVTGGLCGKNSCPCAGLQIRTGSVASLGTDHLYSWAPCSRTFAIELTMSWAKLTMDADQPWEPTSGVTNLSQPSFGVLENWVDLLLLGQLSALATNSVQVEPEPVSFLEESTCPLSPDSDSTATQQVEAVVLKNDQLNDASPISAVTRPNTLTIVLHDSSEDDITCSDLDPNSKNWSKLAQSWDLTIEKRKCEPGTIVIDMFNPVLDTLLEQVLHFRQTVCNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKD2</accession>
    <name>A0A074ZKD2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170029.1">
        <property type="nucleotide sequence ID" value="XM_009171765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKD2"/>
    <dbReference type="GeneID" id="20320670"/>
    <dbReference type="KEGG" id="ovi:T265_06491"/>
    <dbReference type="CTD" id="20320670"/>
    <dbReference type="OrthoDB" id="6229189at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="549" mass="62424" checksum="4B0714E06D83ADEE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKH6</accession>
    <name>A0A074ZKH6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168400.1">
        <property type="nucleotide sequence ID" value="XM_009170136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKH6"/>
    <dbReference type="STRING" id="6198.A0A074ZKH6"/>
    <dbReference type="GeneID" id="20319374"/>
    <dbReference type="KEGG" id="ovi:T265_05192"/>
    <dbReference type="CTD" id="20319374"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7221" checksum="AA2BCD94111EE4FF" modified="2014-10-01" version="1">MSSREGGKKKPLKQPKKAQQEMDEDTMAQKQKKREEQKKLEEARALAASRGPIGQGAKKITKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKX7</accession>
    <name>A0A074ZKX7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoenolpyruvate carboxykinase (GTP)</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168556.1">
        <property type="nucleotide sequence ID" value="XM_009170292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKX7"/>
    <dbReference type="STRING" id="6198.A0A074ZKX7"/>
    <dbReference type="GeneID" id="20319491"/>
    <dbReference type="KEGG" id="ovi:T265_05309"/>
    <dbReference type="CTD" id="20319491"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="636" mass="71698" checksum="AE27B4078C54604B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMH4</accession>
    <name>A0A074ZMH4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_04820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167930.1">
        <property type="nucleotide sequence ID" value="XM_009169666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMH4"/>
    <dbReference type="STRING" id="6198.A0A074ZMH4"/>
    <dbReference type="GeneID" id="20319002"/>
    <dbReference type="KEGG" id="ovi:T265_04820"/>
    <dbReference type="CTD" id="20319002"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF14">
        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="182"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="275"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="419" mass="47376" checksum="F94AC0F52C3397E8" modified="2014-10-01" version="1">MDFGNKYYSRGYEREVTPDVSILDETPSAYTGRVISYPNKTVETRGFIGEKIVMQCNVFNMPRDARIIWRRESFQGGHIAEVINDGLMSRDMSRWKIGQGKQQDSVRLEILSLDETYEGLYTCECQYTGSVEPARIQRVLRVFEKSNTDPVDSNFAIKRVMVDMVKESLMRPCLVLQPRTKPVIVTHRSSYDTDANVNDNVVLQCAAEGIPTPYIYWQRTGGQSSIIRNYGTLKSGNEIRFDAVQADDAGEYVCFAENSMGQALWRVQLRVRHPPMVRIYPFEPSQLVNCNLRLVCTISANPPVLEPAVFWTSNRTGSITADTPRTRIQYLNAGLMRHSVLDLLPVTSADFGQMLTCSATNSLGESSSSVVIQQSPTEVRLVNGRHACNRGTKWTMINMKLLLPVIFIALDRLVFYSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMN2</accession>
    <name>A0A074ZMN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167880.1">
        <property type="nucleotide sequence ID" value="XM_009169616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMN2"/>
    <dbReference type="STRING" id="6198.A0A074ZMN2"/>
    <dbReference type="GeneID" id="20327761"/>
    <dbReference type="KEGG" id="ovi:T265_13594"/>
    <dbReference type="CTD" id="20327761"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF25">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="871" mass="97785" checksum="573DA0A6389B5758" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMY9</accession>
    <name>A0A074ZMY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171590.1">
        <property type="nucleotide sequence ID" value="XM_009173326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMY9"/>
    <dbReference type="GeneID" id="20321909"/>
    <dbReference type="KEGG" id="ovi:T265_07730"/>
    <dbReference type="CTD" id="20321909"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10116" checksum="3097445F95894CAC" modified="2014-10-01" version="1">MESNLASGTHASYIEVKVTAFAHVTKAKYWVDVNGARDLDYNCPEAGNAHVRQKHSKQTENPIRLVRAAFRRTATDFFPRAQTAKKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNQ8</accession>
    <name>A0A074ZNQ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596686">
        <property type="protein sequence ID" value="KER29028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167174.1">
        <property type="nucleotide sequence ID" value="XM_009168910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNQ8"/>
    <dbReference type="GeneID" id="20318403"/>
    <dbReference type="KEGG" id="ovi:T265_04217"/>
    <dbReference type="CTD" id="20318403"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8664" checksum="22D2BBA73F945051" modified="2014-10-01" version="1">MNPRMDEFPVSHSDSATFGGQPPVIETGDDEMKIFATNENRSKLTNRSKTQKPKYVHKGPQAANRIINSRQSKVKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ08</accession>
    <name>A0A074ZQ08_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER29151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167093.1">
        <property type="nucleotide sequence ID" value="XM_009168829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ08"/>
    <dbReference type="GeneID" id="20318345"/>
    <dbReference type="KEGG" id="ovi:T265_04159"/>
    <dbReference type="CTD" id="20318345"/>
    <dbReference type="OrthoDB" id="6280431at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="796" mass="90490" checksum="9052E39D1EE199A8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQA6</accession>
    <name>A0A074ZQA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166634.1">
        <property type="nucleotide sequence ID" value="XM_009168370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQA6"/>
    <dbReference type="GeneID" id="20317986"/>
    <dbReference type="KEGG" id="ovi:T265_03799"/>
    <dbReference type="CTD" id="20317986"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21781" checksum="E0BB9CB737AEFCFE" modified="2014-10-01" version="1">MMASSGISRATFGRTLSLSDAAFGRAEPVIPQNLPLHAHQQKRNNLPLLDPSRHQLTHKWGVLCRRPSVGGSFFQGRIPYDLKEAIEASYLRTPDGKALLTGMRDKYQSSSAYQQTFTSHRTNQKPTHTRLLPAVFGDKSQKTTVDTVRNDSSDGRTDRLLALDVPHFPTSCFVDDQINYHRIRLNSPFALGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQP8</accession>
    <name>A0A074ZQP8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166565.1">
        <property type="nucleotide sequence ID" value="XM_009168301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQP8"/>
    <dbReference type="GeneID" id="20327477"/>
    <dbReference type="KEGG" id="ovi:T265_13310"/>
    <dbReference type="CTD" id="20327477"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="264" mass="30258" checksum="4F7632E4B79509AA" modified="2014-10-01" version="1" fragment="single">MKETSHKVSENSSTAQDLRSPRVSVNQIARNQRTTLNWKQIWYAQSPGFRQPYVLLKIKLHKISEYALICNLTCFFFERLTWNPAESLACDVLRQSSSAVHIQCPCRDLNPGRTSDMRGAQVTTTPPTHSNLFTHERCDWCARPIERRSSNCPGCEDRLTCQSPLPSQTLFRFGATSNSVSMWTHTVWLNGSLRCANRHTTVKSSLFVCYLNPNWTVFEKYTHLQINLVFTRDSTESLVCDIPQLNVLHTGCTMVPIYAMFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRE9</accession>
    <name>A0A074ZRE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166244.1">
        <property type="nucleotide sequence ID" value="XM_009167980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRE9"/>
    <dbReference type="STRING" id="6198.A0A074ZRE9"/>
    <dbReference type="GeneID" id="20317667"/>
    <dbReference type="KEGG" id="ovi:T265_03480"/>
    <dbReference type="CTD" id="20317667"/>
    <dbReference type="OrthoDB" id="6249554at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="862"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="703"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="905" mass="100968" checksum="767C3A38E46D6993" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH1</accession>
    <name>A0A074ZRH1_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER28432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH1"/>
    <dbReference type="STRING" id="6198.A0A074ZRH1"/>
    <dbReference type="GeneID" id="20327750"/>
    <dbReference type="KEGG" id="ovi:T265_13583"/>
    <dbReference type="CTD" id="20327750"/>
    <dbReference type="OrthoDB" id="10611144at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="21732" checksum="D271B2067AFDE16C" modified="2014-10-01" version="1" fragment="single">MMHSTSSPWLQALSPHDSTTAPGYSSSSVMAFNHVYPTLPTAAATLSSNQVHTNQPSLFSLHSHSAFAGDSQTGSSSGDLATDLHSVSGFIFNLFFVLLVQLTDVGYSVQLSSVPGSMLSQLDPIAAAAYYGFETDPAASAPSTNSWYSSSGVDVVSSATSGHVSSTAPQSGSGVTTPTTAKRLHSRTGCSTSNSNSSSAVKNPTGLPPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRQ8</accession>
    <name>A0A074ZRQ8_OPIVI</name>
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        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009168226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRQ8"/>
    <dbReference type="STRING" id="6198.A0A074ZRQ8"/>
    <dbReference type="GeneID" id="20317871"/>
    <dbReference type="KEGG" id="ovi:T265_03684"/>
    <dbReference type="CTD" id="20317871"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF5">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
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            <end position="574"/>
        </location>
    </feature>
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        <location>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="775"/>
        </location>
    </feature>
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        <location>
            <begin position="809"/>
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        </location>
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        <location>
            <begin position="859"/>
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        </location>
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        <location>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="773"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="135924" checksum="22169A4278CABACD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRV6</accession>
    <name>A0A074ZRV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">T265_04610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596696">
        <property type="protein sequence ID" value="KER28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167656.1">
        <property type="nucleotide sequence ID" value="XM_009169392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRV6"/>
    <dbReference type="GeneID" id="20318792"/>
    <dbReference type="KEGG" id="ovi:T265_04610"/>
    <dbReference type="CTD" id="20318792"/>
    <dbReference type="OrthoDB" id="6251906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="579" mass="66977" checksum="AF7A1C97C7A8E5E5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRW5</accession>
    <name>A0A074ZRW5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER29856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009168075.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20317743"/>
    <dbReference type="KEGG" id="ovi:T265_03556"/>
    <dbReference type="CTD" id="20317743"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15116" checksum="5EB87B0859C9ACD4" modified="2014-10-01" version="1">MFAQIHQRTSENMVTGLTKSTMKFKQLNSVGAFPLYLLRVDIRLASVDYVRRKQAYTERTGGHEGSSNLYELGTHLKVMIASLAYAFSTHPILLTHGEVLGHYVRKWLVIGQDIGDDESSEGIIAKFWITRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRY8</accession>
    <name>A0A074ZRY8_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZRY8"/>
    <dbReference type="GeneID" id="20330477"/>
    <dbReference type="KEGG" id="ovi:T265_16312"/>
    <dbReference type="CTD" id="20330477"/>
    <dbReference type="OrthoDB" id="10060792at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5991" checksum="D3924C651989F688" modified="2014-10-01" version="1" fragment="single">DGKTEKKIHVEVPLEPEFGLDNIRVYVESKKLVVHGYKNIPDDKGRYEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSG3</accession>
    <name>A0A074ZSG3_OPIVI</name>
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        </submittedName>
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        <name evidence="2" type="ORF">T265_04453</name>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
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    <reference evidence="2 3" key="1">
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            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_04453"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7856" checksum="39A406C56934DCA1" modified="2014-10-01" version="1">MLGQFTRKEQMEQPPGSRNSRAGQIASAAIRSKMSLSKEFMMDTYLRKIRRDTRARYNQRDRKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZST5</accession>
    <name>A0A074ZST5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Immunoglobulin I-set domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009167502.1"/>
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    <dbReference type="GeneID" id="20317284"/>
    <dbReference type="KEGG" id="ovi:T265_03097"/>
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    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="CONTACTIN 5"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="11"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
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    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
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    <feature type="domain" description="Ig-like" evidence="6">
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        </location>
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    <feature type="domain" description="Ig-like" evidence="6">
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    <feature type="domain" description="Ig-like" evidence="6">
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    <feature type="domain" description="Ig-like" evidence="6">
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    <feature type="domain" description="Ig-like" evidence="6">
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    <feature type="domain" description="Ig-like" evidence="6">
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
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        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="3276"/>
            <end position="3369"/>
        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="1428"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1842"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1973"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2104"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2235"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2366"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2497"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3391"/>
            <end position="3411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3411" mass="374855" checksum="C18449DF1A0E4908" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTQ8</accession>
    <name>A0A074ZTQ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169482.1">
        <property type="nucleotide sequence ID" value="XM_009171218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTQ8"/>
    <dbReference type="GeneID" id="20320230"/>
    <dbReference type="KEGG" id="ovi:T265_06048"/>
    <dbReference type="CTD" id="20320230"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="184" mass="20879" checksum="A9BF0B54FAB41ABB" modified="2014-10-01" version="1">MLSVSARSTFGVRPRRRAHGVPREFPFVISRLTIGSRLTRSGKSFFDPTTLVPQKVFEESSQISKAFHRRCQPLGQQDVCQHAGSQLHPICNKSTGREPQVLFCNQVSILINYSAVPLPSCHATRKRHEGWNTARFPKPRQGKSRARGRVRTTDLPVRNRPTETKRVIAKVKKDSPSIQQSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTU7</accession>
    <name>A0A074ZTU7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165722.1">
        <property type="nucleotide sequence ID" value="XM_009167458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTU7"/>
    <dbReference type="GeneID" id="20327319"/>
    <dbReference type="KEGG" id="ovi:T265_13151"/>
    <dbReference type="CTD" id="20327319"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15601" checksum="A0B93B1386A1F446" modified="2014-10-01" version="1" fragment="single">SANLLTGRSVVRTRPLLLDFRCLGLGDLAVSQSLCLLRVALQLDTERVLQLEDFSITPFVRPKGGHLSSSMQTKPKNKNCSAATLFRCLSAMPPEGNTTTETPPGCSGLDRSSYTAEVGLEPHPFRSVKLRLSHWAIQISAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUD8</accession>
    <name>A0A074ZUD8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_03928</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166793.1">
        <property type="nucleotide sequence ID" value="XM_009168529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUD8"/>
    <dbReference type="STRING" id="6198.A0A074ZUD8"/>
    <dbReference type="GeneID" id="20318115"/>
    <dbReference type="KEGG" id="ovi:T265_03928"/>
    <dbReference type="CTD" id="20318115"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="414"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="463"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="489"/>
            <end position="492"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER29462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="566" mass="62167" checksum="B9B9FF3EE02D7AA1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV76</accession>
    <name>A0A074ZV76_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166460.1">
        <property type="nucleotide sequence ID" value="XM_009168196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV76"/>
    <dbReference type="GeneID" id="20317841"/>
    <dbReference type="KEGG" id="ovi:T265_03654"/>
    <dbReference type="CTD" id="20317841"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="15219" checksum="A3C40099E47CEF86" modified="2014-10-01" version="1">MPEETFHLTTPSAWRLVQLGHMVVKLCPTGQRLQDQKIYQNRWSHLNRTNQSPQSHTYITSPHPKLEWQEHQNQCVSLSKSVKSHEAWCVLCDRCPFPFVHTWCMSCTSSEKPSFDKVNQFLMHLSYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVB8</accession>
    <name>A0A074ZVB8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596726">
        <property type="protein sequence ID" value="KER27310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168957.1">
        <property type="nucleotide sequence ID" value="XM_009170693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVB8"/>
    <dbReference type="STRING" id="6198.A0A074ZVB8"/>
    <dbReference type="GeneID" id="20319816"/>
    <dbReference type="KEGG" id="ovi:T265_05634"/>
    <dbReference type="CTD" id="20319816"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="33820" checksum="596A6FE1072E09ED" modified="2014-10-01" version="1">MGRAHSQLCHPVTAAINELTEELIRHYEMQSCIPIEFLEPNCLIYTAHGGLSARQRATIRALVNYAFLRAVHIRQTSSVLLLNGPPAISDLSSSITHGDTTGLVEHGNGTGTGYKVRNELTDSRGVQLSSFALISRVKKIQVDKLPTCPVCLVDYQENDLIITLPCFHVYHKACTGPWLKSDEGCAMCRLSPLDLIHNTKALLAQVAEEKRLATRALGLHIQVVSPKRELTNQPNDFVFNINASLPYKSDLFESLIVKKRGKTFTQAIWTETDNRNATDIGGQPFLVVYPTRHSEDHAVPILEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVR2</accession>
    <name>A0A074ZVR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164654.1">
        <property type="nucleotide sequence ID" value="XM_009166390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVR2"/>
    <dbReference type="GeneID" id="20316390"/>
    <dbReference type="KEGG" id="ovi:T265_02202"/>
    <dbReference type="CTD" id="20316390"/>
    <dbReference type="OrthoDB" id="6229471at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="345" mass="38959" checksum="9511B054C9731468" modified="2014-10-01" version="1">METRDYMVGETKRIINNVAHFEDKIKLTGFRVCNNQEYAIRSSAASLMHTNDRKTSASLRLICLHDNIVFSPPLYIDNIYHRQSIPHKNIIGFFLAPNYETRLVLVVQEESTRNINLYGIELSSVRKAHEITSLLGETHSPSVGESSNIAPSPTYSVSKSVNYFDQFLHENSSMINKLQKSDSSSVSPKSWNSKGKSDRGLEERRNISSTPTDSPMQNGFNRHSTWNSPKCGIRTPTKFPGIISSDIEYDWDDVMSPLRPKIPDDIDERISIGYYNDDTECDYSPKLSPKKTDHESDSSVPAPQNAWMENITYISNHPTKGSYVTSTGSVYMYVAQQVNPRTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVS7</accession>
    <name>A0A074ZVS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596722">
        <property type="protein sequence ID" value="KER27480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168794.1">
        <property type="nucleotide sequence ID" value="XM_009170530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVS7"/>
    <dbReference type="STRING" id="6198.A0A074ZVS7"/>
    <dbReference type="GeneID" id="20319690"/>
    <dbReference type="KEGG" id="ovi:T265_05508"/>
    <dbReference type="CTD" id="20319690"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="92089" checksum="AAABBF46DA1ADEE6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW28</accession>
    <name>A0A074ZW28_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">26S proteasome regulatory subunit RPN9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">26S proteasome regulatory subunit S11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">26S proteasome regulatory subunit p40.5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02379</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164876.1">
        <property type="nucleotide sequence ID" value="XM_009166612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW28"/>
    <dbReference type="STRING" id="6198.A0A074ZW28"/>
    <dbReference type="GeneID" id="20316567"/>
    <dbReference type="KEGG" id="ovi:T265_02379"/>
    <dbReference type="CTD" id="20316567"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="175"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="430" mass="48434" checksum="32C8EA36B5393853" modified="2014-10-01" version="1">MDIPPAISAYLDGKINGTPEFQAEWTEIKDFYARKLWHQLTTKLQACLSLPNFKAQTNLIELNEVFLNDFKNKYVFLILSGTDYNLVASRINPLALAELCVPISEQLVANDPQKGIQFMEEIRDKHTQKSKEAVILCNTTIGMIYLTTLNDLANARQVIETTGAQLEQLGGVTCVHSRFYQLSSRYYQVTAQHADYHREALRFLGCVNLSDLSREEQHAWAFSVGLAAILGEGVYNFGELLTHDVLNSLLDTPDAWLIDLLNAFNRGDISQLEALRSQWSTQADLVAAESRLKDKVTLLCLAEMIFRRPPNKRTLTFAEITAATRVPEDQVELFVMRAMSLGLIKGRIDEVNHSVSISWLKPRVLDREQFPPSLRALLTAIRSVSGSHSDDLIDDFFLQIGSMRARLNEWCNSVSDTKNLVEVNAKAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWW7</accession>
    <name>A0A074ZWW7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596713">
        <property type="protein sequence ID" value="KER27840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168406.1">
        <property type="nucleotide sequence ID" value="XM_009170142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWW7"/>
    <dbReference type="STRING" id="6198.A0A074ZWW7"/>
    <dbReference type="GeneID" id="20319380"/>
    <dbReference type="KEGG" id="ovi:T265_05198"/>
    <dbReference type="CTD" id="20319380"/>
    <dbReference type="OrthoDB" id="6244601at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF12">
        <property type="entry name" value="CDNA SEQUENCE BC034090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="400"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="494" mass="54902" checksum="AB4CE41C6C96901D" modified="2014-10-01" version="1">MQPRRIVRGPLRALHANCTEEITNNLPRDYEECFTPSVDGNSSMVKQDTPATPLVRVHSSGVVGRRRSLQPLRTSSCRSDRPHNLVSAEDIRCHFPIRVLSGKYLTPCEASKTSDDNETTIVSPLRSGYKRSGSYVPDEEEVTQSKQICYSNQCSDNNYSENKLTMGAYVKTHPRYFRRRNSADCMRQPISDRGKVCDVNVTAYISRLSPICPVPMPEGFPLQLPPCATVSLPWEARRAMLTPRQPQRTAETQTSPTESTTTVCGQKCSRSKRQSFGSSQMLVGLRKTFGSLRRAISAERLHRSSNSLLGSTERNSSQKPTPPKSAKLKLKTLVCKRSSIQRSSIGVGTNSAVMIKTTSPKQSDQSNHQKSTATAPFTNEVNGSKLTCQVVSKLPDGSIRIALRRGSTRQQFGFFIARDSDGIYISRLGGVRSAVKFWDLFRVGDRILEVQGTSCSKLDVEDVQNLTRGCELVEFRIKPTHASNFTYSLTQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY30</accession>
    <name>A0A074ZY30_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165421.1">
        <property type="nucleotide sequence ID" value="XM_009167157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY30"/>
    <dbReference type="STRING" id="6198.A0A074ZY30"/>
    <dbReference type="GeneID" id="20327268"/>
    <dbReference type="KEGG" id="ovi:T265_13100"/>
    <dbReference type="CTD" id="20327268"/>
    <dbReference type="OrthoDB" id="5804959at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="246" mass="28105" checksum="B14C04B164A4CB91" modified="2014-10-01" version="1" fragment="single">LENGYDYVNITEGRRSLGVWSGSESPPPLQSFETELTVTMTSDHSIQNTGFLANYSRRGNSANDRAATESWYFCTSNLGSGQLTSPGYPHGYPRTLRYTWIIMQPEGCTIQLNFTDFMLEDQFDFVSVHNVYRFEEGSRLGQWSNLPPSVKSTSSRLLLEDQFRFCSVHNVYRFEEGSRLGQWSNLPPSVKSTSSRLLVAIRTDGPVARKGFSANYNTRRERDHHSTNALWTRLNFYVRTGKRIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY35</accession>
    <name>A0A074ZY35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transducer of regulated CREB activity N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165293.1">
        <property type="nucleotide sequence ID" value="XM_009167029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY35"/>
    <dbReference type="GeneID" id="20316902"/>
    <dbReference type="KEGG" id="ovi:T265_02714"/>
    <dbReference type="CTD" id="20316902"/>
    <dbReference type="OrthoDB" id="6241105at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="88812" checksum="125C711EDD159DD1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYE7</accession>
    <name>A0A074ZYE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164152.1">
        <property type="nucleotide sequence ID" value="XM_009165888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYE7"/>
    <dbReference type="STRING" id="6198.A0A074ZYE7"/>
    <dbReference type="GeneID" id="20327021"/>
    <dbReference type="KEGG" id="ovi:T265_12853"/>
    <dbReference type="CTD" id="20327021"/>
    <dbReference type="OrthoDB" id="6267753at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01345">
        <property type="entry name" value="CERVTRCPTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126268" checksum="71C950C3EEE3E24A" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYH1</accession>
    <name>A0A074ZYH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_01743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164097.1">
        <property type="nucleotide sequence ID" value="XM_009165833.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYH1"/>
    <dbReference type="GeneID" id="20315931"/>
    <dbReference type="KEGG" id="ovi:T265_01743"/>
    <dbReference type="CTD" id="20315931"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1453" mass="162051" checksum="FD80390D059C42DC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Q3</accession>
    <name>A0A075A0Q3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_10571</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL597003">
        <property type="protein sequence ID" value="KER20994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175246.1">
        <property type="nucleotide sequence ID" value="XM_009176982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Q3"/>
    <dbReference type="STRING" id="6198.A0A075A0Q3"/>
    <dbReference type="GeneID" id="20324739"/>
    <dbReference type="KEGG" id="ovi:T265_10571"/>
    <dbReference type="CTD" id="20324739"/>
    <dbReference type="OrthoDB" id="6227030at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="13">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="472" mass="52897" checksum="B3DD1C0E0B5E083E" modified="2014-10-01" version="1">MTRNIRGGHIRLRLAMWIQCPDNSYGPRCQNRCLPEHSRNGRHYGCVLSDGSRVCMPGWYGPQCDEVDICDTRRPCGPTGICKKVDDGFQCICTKEFTDPICTQPRSPCQSYGSLSGGTPTDPYCMNSGLCVLDEQRARRCICMPGFTGTRCEHDVDECSHWYSIQHSREVTEVPEKIAEVIKCYTPGHVASPCCGEESVCVNKFGGYTCLCPIGWTGLHCEYPPTLWPPGFQPQVNESVGYGNVDFGLWSVKAPTTENVKIYRLLVDCGIRCSVSDPILDANWSRHLLCVSLAPSQQTGDVTHATDDASSTGYWWIVAFGVLFLILFLTLIGVVICCVFHWRRRIKPEMLPMRPLPEPYHHQPKRYSRPNNMDSCKGSVSNALYTIQPGPTSFPLLYPTLPKEADWDTIPKSPAGCSIQDTMYEALSDRHSEYDSLVLPGEDEYEKTEETPKSMDSEAQNINESEKLMIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Y5</accession>
    <name>A0A075A0Y5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162820.1">
        <property type="nucleotide sequence ID" value="XM_009164556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Y5"/>
    <dbReference type="STRING" id="6198.A0A075A0Y5"/>
    <dbReference type="GeneID" id="20314895"/>
    <dbReference type="KEGG" id="ovi:T265_00707"/>
    <dbReference type="CTD" id="20314895"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="363" mass="41385" checksum="E5BA63FC2732982C" modified="2014-10-01" version="1">MDLDTLRLLASAIAQNPDAEAEDEYLIKQFNGFLRFLLNENRTSSPDQQEAFKLSLNCLTNLCWSCHRNELLRKAIGTDERCRTFVSLIKDMLFQNLNPALRPLVIGLLCNLTRDEVWAARFFQDDHERLISAVLPAKVIIDDTIPLLLNMTSNRELRRRLCANGTFQIQLLSRFASESDAERAVLLAGIVKNCCFEDEYHPQLLGPRSQLLEVILRPLCGPEDNIDSEDKQALPVSLQQLIGNPSTVRSKSNELKSTICHALLQLCATSWGRNRLRSVGTYFILRELHKYEGSKLSDGTLNDIEILSTKSLLYDIEQVVDQLICEERDRDQATTEKSLRDIEVDDEMAQKLERDRVDYIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A159</accession>
    <name>A0A075A159_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162673.1">
        <property type="nucleotide sequence ID" value="XM_009164409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A159"/>
    <dbReference type="GeneID" id="20314769"/>
    <dbReference type="KEGG" id="ovi:T265_00581"/>
    <dbReference type="CTD" id="20314769"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="189" mass="21573" checksum="C0E943F9A44294F6" modified="2014-10-01" version="1">MRQTAHLTKFTGWCFRTPLPGHTLSTSQSLPLRTRLTEKSSVRQTVFWHAEYTSQPAQPMKHTLEGHLPENIINERFSWVPAPTEQLQTIGQGSKPLICILFTKSKYPYSSRTRLFELSWMLIEYHSNCLVTMPPEGGMRAEILPGYSGIDRSSRDTGAVFEPLCRAQGLLLRQIHSFANQFVSHEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A183</accession>
    <name>A0A075A183_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_12870</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164236.1">
        <property type="nucleotide sequence ID" value="XM_009165972.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A183"/>
    <dbReference type="GeneID" id="20327038"/>
    <dbReference type="KEGG" id="ovi:T265_12870"/>
    <dbReference type="CTD" id="20327038"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF566">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1106"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1139"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1465"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1685"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1807"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1140"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1492"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1685"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1848" mass="204010" checksum="CFC22CDEF5BC2302" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A293</accession>
    <name>A0A075A293_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163918.1">
        <property type="nucleotide sequence ID" value="XM_009165654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A293"/>
    <dbReference type="STRING" id="6198.A0A075A293"/>
    <dbReference type="GeneID" id="20315783"/>
    <dbReference type="KEGG" id="ovi:T265_01595"/>
    <dbReference type="CTD" id="20315783"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="30894" checksum="BB993B289E9339E4" modified="2014-10-01" version="1">MHRATDRKFQFGFYTPQRTGKTEEFDSSPGYITDVGKFSLTDELLYLCPSDLERFLSQPQSGRIHKAEDSAIESALKSGRDVIPGVVEGGLTVWDGSKQLIAYLARKFSPSVFCGRRVLELGCGCGLPGLTALKYGASVVTFQDYNHEVITNWTIPNVLLNLGSTLDAETLRSSVNFYSGDWVQLARRWESDREQPYDIILTAETIYRPDLYDRLLRAVAATLNKDGSVFLMCKAAYGPGGTLCDFVEAVDASGLFRPEVTEIQEDGAVTFIVQLTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A307</accession>
    <name>A0A075A307_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162451.1">
        <property type="nucleotide sequence ID" value="XM_009164187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A307"/>
    <dbReference type="GeneID" id="20314602"/>
    <dbReference type="KEGG" id="ovi:T265_00414"/>
    <dbReference type="CTD" id="20314602"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9643" checksum="D653A1CD184C4900" modified="2014-10-01" version="1">MFLPIDESHQTSASALIPLIASGPHGSEELRPHQKCSVQCGLVRNHIFPALEGKMKTEEQKIVYGDRLTELEQSPAGCGKAAPAYAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3C6</accession>
    <name>A0A075A3C6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162329.1">
        <property type="nucleotide sequence ID" value="XM_009164065.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A3C6"/>
    <dbReference type="GeneID" id="20314508"/>
    <dbReference type="KEGG" id="ovi:T265_00320"/>
    <dbReference type="CTD" id="20314508"/>
    <dbReference type="OrthoDB" id="6273819at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024836">
        <property type="entry name" value="JAKMIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18935:SF8">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1629"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1888" mass="212020" checksum="07F473CFCA0FADA7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3E0</accession>
    <name>A0A075A3E0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162343.1">
        <property type="nucleotide sequence ID" value="XM_009164079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3E0"/>
    <dbReference type="GeneID" id="20314522"/>
    <dbReference type="KEGG" id="ovi:T265_00334"/>
    <dbReference type="CTD" id="20314522"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="188" mass="20613" checksum="05FB4E4D5904BD12" modified="2014-10-01" version="1">MACILQQTNPKLRSYVDKLQGGIGRNFTATTLYRSRLGAATAEKCMPHQIGQKFWPLASELRLVETPSNATKLELAKLGVKNCSSRFNKSDSPDPPVIVEAFASLEGRLCMSDSPNLGLVLVPYPYTEVGLLSLRPSLHKRELWSVGAGGTRRVTNDGVMVARSSNITCFVFKDEDDVVKGSKVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A498</accession>
    <name>A0A075A498_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596911">
        <property type="protein sequence ID" value="KER22209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174028.1">
        <property type="nucleotide sequence ID" value="XM_009175764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A498"/>
    <dbReference type="GeneID" id="20323802"/>
    <dbReference type="KEGG" id="ovi:T265_09634"/>
    <dbReference type="CTD" id="20323802"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10646" checksum="F246EC94C378C5EA" modified="2014-10-01" version="1">MSAILLKHCRVEEGTSKVMHDELECSPTVNQSINTDYSQGVGQWFLQRFDELNGSAIIHRERNRSVRYTLERAHRSENNPHSESSTSKSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4I8</accession>
    <name>A0A075A4I8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163022.1">
        <property type="nucleotide sequence ID" value="XM_009164758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4I8"/>
    <dbReference type="GeneID" id="20315051"/>
    <dbReference type="KEGG" id="ovi:T265_00863"/>
    <dbReference type="CTD" id="20315051"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="422" mass="47525" checksum="76AF5C1185050074" modified="2014-10-01" version="1">MALFNTRKNLTDLVPIIRWQLKHLSVFGTVSDPIDSYFIGLQLFTFMRHLGTLNPKKSQSSYEIRPAQEDNFSVSLMGAFNGSPMNFTQGILTLLDGSSDFLQGLNFTVAPRVPSVGCFVATLTQISYRLSELRENSSTDGITLSIEKLERNVSNPPGAQVAVCLNSSLNESLHLTVRGQTGWELQSIPKSAFVSTSVVSITEDNVVHFVLAMEQYAGCLEFLYTQTAIMSFAHPMKVIAKSSTPVGSRKTEAFYLLPTSDNPSDIRPSFSQSHRWTSKKDCRNFRVRPFEYWNAMRNFSGDVKTICKAPVFLFHLQIKDAWLLVAHVSAKREICIWQLQISRLWSQCFGGLKEWTIVNTVTDEFIQQLSIEQTLEFISRSPNTLTLDGAEFDEFLFANEANGCRNLPELKTMMGDNLTYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4L4</accession>
    <name>A0A075A4L4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162079.1">
        <property type="nucleotide sequence ID" value="XM_009163815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4L4"/>
    <dbReference type="GeneID" id="20314346"/>
    <dbReference type="KEGG" id="ovi:T265_00158"/>
    <dbReference type="CTD" id="20314346"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8649" checksum="FE0A4C4EC280E145" modified="2014-10-01" version="1">MTWQRSTRTLTRKLSRVANCGLPGCPGMHLIDVSGINENQLILKRHRAVVSDLLPSTPFKDEGKILSRWLSTLYASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A694</accession>
    <name>A0A075A694_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_00309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162318.1">
        <property type="nucleotide sequence ID" value="XM_009164054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A694"/>
    <dbReference type="STRING" id="6198.A0A075A694"/>
    <dbReference type="GeneID" id="20314497"/>
    <dbReference type="KEGG" id="ovi:T265_00309"/>
    <dbReference type="CTD" id="20314497"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="29091" checksum="40AD7C1E0CD47079" modified="2014-10-01" version="1">MFAGLKSVNYEARLAMLDLFPLEYCRLPGDLILTCALFEQSLANRSRGLKARCVNFCLGVTVLRCTQLPASASAQGLMQEYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQMEIGGKQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLCYSITSQSSFNDLEELHQQIRRVKDVDQIPMILVGNKCDLDTERVVGKEQGQRLAREWGCEFIETSAKTRLFVDEVFINLVGQINGLMPATKQKRKKQCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7M5</accession>
    <name>A0A075A7M5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172770.1">
        <property type="nucleotide sequence ID" value="XM_009174506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7M5"/>
    <dbReference type="STRING" id="6198.A0A075A7M5"/>
    <dbReference type="GeneID" id="20322819"/>
    <dbReference type="KEGG" id="ovi:T265_08640"/>
    <dbReference type="CTD" id="20322819"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111404" checksum="90E27D690D38CD4D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAQ3</accession>
    <name>A0A075AAQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163391.1">
        <property type="nucleotide sequence ID" value="XM_009165127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAQ3"/>
    <dbReference type="STRING" id="6198.A0A075AAQ3"/>
    <dbReference type="GeneID" id="20315354"/>
    <dbReference type="KEGG" id="ovi:T265_01166"/>
    <dbReference type="CTD" id="20315354"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="474" mass="53591" checksum="71046184770E4A6F" modified="2014-10-01" version="1">MSSDKRHVNNQETPPATDALSVSTVDDLEESILIVADPHNLGENLTEPHTLMNFIKGNIGTGVLSMPVVLRYSGLWTGFFMIIFAGSVASYLMKVLVRTSRSVREKYNLDRSKMDYTETVFYVFKYGPPCLRKPKGKIKHTVNVFLIVTQIGFSCVYTLFITDNLRYFLHAFFPDLYLNFYVVALIVCVCLIPMSLWSSMRVLAHLSAVANLATLIGAMLIFAYLLSSGLLPFSTLPVYTNPRGILIGFSIVMFSFEGISLVLPIESKMAHPEFYLHPFGVLSVGMTIIISLNAAFGFFGYLKFGEKAEGTITLNIPHSPWWFSPVQPLFVVAICFTYLLQFYIPASIFARLMEKLRCHREASERRRYINLKVMRALLVMFAYVMVITIPKLDLMISLIGAFASSILAFILPPVLEIVHLWEDRHHIKWFWLTVVVKHAFFLCIGLLSFVGGTVATLLQLIEAFNTPDQPKSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABK0</accession>
    <name>A0A075ABK0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163037.1">
        <property type="nucleotide sequence ID" value="XM_009164773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABK0"/>
    <dbReference type="GeneID" id="20315066"/>
    <dbReference type="KEGG" id="ovi:T265_00878"/>
    <dbReference type="CTD" id="20315066"/>
    <dbReference type="OrthoDB" id="7934525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="34249" checksum="199F7BA8F32DDBD4" modified="2014-10-01" version="1">MSVYLVISCNLVSRLTEIRGLRLPDEPQKVNQGMRMNTVSWSESHRWWYMNWKGGTIILENAEVLGRGLRSISWWLTAEGVEVNKHHSVNRIEDVERACVWRAVLGKSSWQATPLVKCWNIFLRRNSGSRRVCAGCGWRQRVSNEVIRKRVFGCAAGTSIRENIQHHRLRWLGHVLRMPMHRLPRRVLFSVPPSGRAQPRGGQHMTWRKGIKEITKSLGVAGVDGVPATPPVLGWRRCKKWRLIDVSGVCAVSFFPDCLIEWLENIRLTETRELRLPDELQEGRNRSWAVEEFSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC22</accession>
    <name>A0A075AC22_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162846.1">
        <property type="nucleotide sequence ID" value="XM_009164582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC22"/>
    <dbReference type="STRING" id="6198.A0A075AC22"/>
    <dbReference type="GeneID" id="20314921"/>
    <dbReference type="KEGG" id="ovi:T265_00733"/>
    <dbReference type="CTD" id="20314921"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="464" mass="52480" checksum="78F4692B149A746B" modified="2014-10-01" version="1">MMHCEISFGYQVPYFLRLLRPISLFEYVRGIEKERLLITAMDKWSKLRPRLVLLLELFSSRVFEVLPDDILEFSSEFFSELNSKPDKWEIFNDRHRAETAKLPYTVQLIPTSGTPANVQPDRGTPICTVSPAEAQQQSMTDVSDEYTGGSGSLLAVEGQEEIAAESFDPEVEDSGESVIYPKTAAQRQRINEAIQSIFIFRSLDETQLNKVVDAMEEFPVHKDQVIIRQGEDGEYFYIIERLGVDIQRTSRLNGAFLFLSSGSYDVFVEEQPAGIYNGAGYFGELALMYNTPRAATIKCTSDGILWRVDRFTFRRIVLKQAFRKRQLYETWLSNVPLLKNLNFYERKNLADALVSVTFEDGSWIVRQGEPGEVMYFIEEGNVQISVNTSASAMAVGKTVLAALDVRSFERLMGPCLNVMLREAGQYRSELINILGEASLNSFSALARLSTFSTEEDATATNKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC33</accession>
    <name>A0A075AC33_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162855.1">
        <property type="nucleotide sequence ID" value="XM_009164591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC33"/>
    <dbReference type="GeneID" id="20314930"/>
    <dbReference type="KEGG" id="ovi:T265_00742"/>
    <dbReference type="CTD" id="20314930"/>
    <dbReference type="OrthoDB" id="6230928at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="504" mass="55567" checksum="B5C0ED85585D75EA" modified="2014-10-01" version="1">MPVQELDSGVASEEEFHSLADVTCNCELCHARLYVSSKQNVIEDSLLDHSDAFHLLPSPKSGTPNPPQFPAPIFYPWSCPMPVYTDMSPFACGSFNKCFCPNGNKINPDMAGHMNPICEFPCRPNVGLLAFDQEGDVSSACTVPQVYISKDCVLHIRLSAYVSFERSVSAYRLINYRNNSALALNESGEYGYAYHYNCRGLINMHHGKLSITFDKDRQVLLRTEKPSFVKKEMEFYRLTSHHWTACRPVSMDTFDRDRTPEILKKIGIEKSLDDAKLRELVSSSAVHKTGCGLVIYLGDAKIEQKVNGDVVLSWFYEDRANSLIVSPLSGSFSLSTKNLEIMATPRSDIYIAFGDFFVHVGSQQMTVSSGAVAGRCNFTKSHPCLLKLTSTIVENQAVDLRQYCAYSQSVGQTGPTPTGNHHRRQTPITSSAFSGNVASSYCSISQTNRNISPASQTSASGETTSDKRNDNTCSSSSKETHITNVKSETSILTGPKSAQPTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACP8</accession>
    <name>A0A075ACP8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger, C4 type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162445.1">
        <property type="nucleotide sequence ID" value="XM_009164181.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075ACP8"/>
    <dbReference type="GeneID" id="20314596"/>
    <dbReference type="KEGG" id="ovi:T265_00408"/>
    <dbReference type="CTD" id="20314596"/>
    <dbReference type="OrthoDB" id="6263305at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="672"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="1368"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="800"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1123"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1510"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1702"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1743"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="813"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1123"/>
            <end position="1150"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1794" mass="189300" checksum="9896FCDF483B211B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACW8</accession>
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            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">T265_14166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25669.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
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    </dbReference>
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        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
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        <property type="entry name" value="ARFGAP/RecO"/>
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    </dbReference>
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        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
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        <property type="entry name" value="FI20236P1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REVINTRACTNG"/>
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    <dbReference type="SMART" id="SM00105">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARFGAP"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <end position="756"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="825" mass="90490" checksum="003D89DB111F5EE4" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADU2</accession>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596752">
        <property type="protein sequence ID" value="KER26279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADU2"/>
    <dbReference type="STRING" id="6198.A0A075ADU2"/>
    <dbReference type="GeneID" id="20320651"/>
    <dbReference type="KEGG" id="ovi:T265_06472"/>
    <dbReference type="CTD" id="20320651"/>
    <dbReference type="OrthoDB" id="10065861at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
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        <property type="entry name" value="FCH_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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    </dbReference>
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        <location>
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            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
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            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="878"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEG1</accession>
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        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13951</name>
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    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169581.1">
        <property type="nucleotide sequence ID" value="XM_009171317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEG1"/>
    <dbReference type="STRING" id="6198.A0A075AEG1"/>
    <dbReference type="GeneID" id="20328118"/>
    <dbReference type="KEGG" id="ovi:T265_13951"/>
    <dbReference type="CTD" id="20328118"/>
    <dbReference type="OrthoDB" id="10061772at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="94"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="545" mass="60439" checksum="876282A9066D5934" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEJ3</accession>
    <name>A0A075AEJ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169490.1">
        <property type="nucleotide sequence ID" value="XM_009171226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEJ3"/>
    <dbReference type="GeneID" id="20320238"/>
    <dbReference type="KEGG" id="ovi:T265_06056"/>
    <dbReference type="CTD" id="20320238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="356" mass="39665" checksum="ACCE08475EB84D50" modified="2014-10-01" version="1">MSEIRALRSVGLCDHWSCEQTTRVLVYGQILVPKRTHWGIVGGPAVLEGNEARNSLCENADSKRNVKIQMRPTCVGGVVVTRSLRMSDVRGSKPGTATGYALLMSSNKNETRVQDEIPAVSSILSTHEAPSESDRRLLGQQQLGSNKSEEHRMRPLQEPLTEHRVEFSPMAGSGRLKEQTTYLFVKMWRGSTQKAGHGMSKGPVPPSMQYGKDEIIVINTKDGTKLASARNRIRSASALPRAWMATAVAWPRTLIPSASACAMRTFRALLCMRKVNIFPESSWRFGCQLRSERPDEHDHIRPPGVGKDMCQLNCVGHTLIVTTQAFNHFQHRKAVDKSMGVEEYHGGHRVRENSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF02</accession>
    <name>A0A075AF02_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169036.1">
        <property type="nucleotide sequence ID" value="XM_009170772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF02"/>
    <dbReference type="STRING" id="6198.A0A075AF02"/>
    <dbReference type="GeneID" id="20319885"/>
    <dbReference type="KEGG" id="ovi:T265_05703"/>
    <dbReference type="CTD" id="20319885"/>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2430">
        <property type="entry name" value="NFRKB winged helix-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025220">
        <property type="entry name" value="NFRKB_WH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038106">
        <property type="entry name" value="NFRKB_winged_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14465">
        <property type="entry name" value="WHD_1st_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear factor related to kappa-B-binding protein winged helix-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear factor related to kappa-B-binding protein second winged helix" evidence="3">
        <location>
            <begin position="383"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="544" mass="60733" checksum="4C02475D539E8DB8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFZ3</accession>
    <name>A0A075AFZ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_04890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168014.1">
        <property type="nucleotide sequence ID" value="XM_009169750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFZ3"/>
    <dbReference type="STRING" id="6198.A0A075AFZ3"/>
    <dbReference type="GeneID" id="20319072"/>
    <dbReference type="KEGG" id="ovi:T265_04890"/>
    <dbReference type="CTD" id="20319072"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER28214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="503" mass="55559" checksum="AD2F6332F9F21571" modified="2014-10-01" version="1">MHVQFEHQMLFANAFKRQEQYQQKPLQDPTSSPLADSGDNENTLDNAIVPQKPSGIESDMRIPSTTQREQPSSVETQTVISSFRSPMRYRRKRVYPSCCTSLQTSVDETTQGFVCTAASVSGCSNPEICCPPSTVVCNCQCLYASPSQSTSCPACVSSSQSALECVSCEQSKPVENSVAMKTSPCCLPLTCPTTLSSEKRTSDRSQRAITSCCPCSPKSTKPIMASTEAQTDFELEFTGPDYEDIAMLLSSPFKSDITSPVQPDQSASESMPDLKGYTQIDTPTSPRMTNLSFEGNTPSVLPTREPTKTNQSLGNSSSVVSSASYQPVDSSINTAITFSAANLPVTMIGRDSRIVASSCLAQTPVSTQSLITTPLISGLQIETNRPQFTCDHCGRAYRQKVHLRKHILIQHVGKKPFECPLCTYTTVEKSHLTVHIRTHTGERPFRCRVCDYSSSQNCTLKAHYMRKHSDNCLYCAKCSERFFTEQELHKHERQCFSEKKMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHU8</accession>
    <name>A0A075AHU8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165804.1">
        <property type="nucleotide sequence ID" value="XM_009167540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHU8"/>
    <dbReference type="GeneID" id="20327338"/>
    <dbReference type="KEGG" id="ovi:T265_13170"/>
    <dbReference type="CTD" id="20327338"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12912" checksum="0DEE75F69CB530F4" modified="2014-10-01" version="1" fragment="single">LEQSLAIAILPSYFCRTGLSAKSQRRSVERDGGGDKKVPSHTKVSLRRISPNPNVRLFFEKDRHFREPMVKYRYTFSEEDSEHAFIRTKVLREFAGDRWKSKYRCMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHZ0</accession>
    <name>A0A075AHZ0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Talin 1-like rod-segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165487.1">
        <property type="nucleotide sequence ID" value="XM_009167223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHZ0"/>
    <dbReference type="STRING" id="6198.A0A075AHZ0"/>
    <dbReference type="GeneID" id="20317058"/>
    <dbReference type="KEGG" id="ovi:T265_02870"/>
    <dbReference type="CTD" id="20317058"/>
    <dbReference type="OrthoDB" id="10644989at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054060">
        <property type="entry name" value="TLN1-like_RS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21865">
        <property type="entry name" value="TLN1-like_RS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Talin 1-like rod-segment" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="274" mass="29648" checksum="F9EB9DF837D0FAC9" modified="2014-10-01" version="1">MVSMEGHLQPGRELNKEGFQKQLATCCRALPDASPSVGRSARSEAEKLGHSIRVAYSYLLGITSSAIIAASRSPLSITCGFTRIIAPGQEDDCSNESDVNVNNTHPTNHNTTCIKLVFSGLSTPYFTRVSHDKRTGRFSVSRMSDGALHLTCIRFEFYAGGLLPFCQNNGVYDSLYTRLQKALGDIRHVILSPADPSSEKMGETMGEGGDIVLAYVKHSELPTHPTAQSGDVEKTASTNATDTDQPSFLAMAPAKHRWSHADPITDGVEHPNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI74</accession>
    <name>A0A075AI74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165127.1">
        <property type="nucleotide sequence ID" value="XM_009166863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI74"/>
    <dbReference type="GeneID" id="20316772"/>
    <dbReference type="KEGG" id="ovi:T265_02584"/>
    <dbReference type="CTD" id="20316772"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11811" checksum="DCF301005ECA4F62" modified="2014-10-01" version="1">MWANVYSGEQLGERQTVFNPNSIRRKKNYEVIQLGPKNIANTASETDQEPEHSVSLPYGSEDSATVQLTAHLRHITVRFGPARLLHLKKLGGERRACIQMIRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ80</accession>
    <name>A0A075AJ80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163418.1">
        <property type="nucleotide sequence ID" value="XM_009165154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ80"/>
    <dbReference type="STRING" id="6198.A0A075AJ80"/>
    <dbReference type="GeneID" id="20315381"/>
    <dbReference type="KEGG" id="ovi:T265_01193"/>
    <dbReference type="CTD" id="20315381"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="316" mass="34854" checksum="627D70DBB9F0371F" modified="2014-10-01" version="1">MPINQTITSSVRYQPKTTMEAQPLPDSPMNDAVNQSKDSEDNEPGSLPHITIPGSNQDSDSSPTASISPGIATRALGPCAECGLRINQLSDACHALGYLYHNACFVCCYCQRTLSGKVFYKDQEKIYCEEDYLYCGFQQVAEKCCACGHLISERILQAMGNSYHPGCFNCSVCTKCLDGVPFTVDSNNLLYCLPDYHLVHAPQCGACGYMIVPDGASNEVLRVAALDKEFHLDCYRCCDCKKLLGDEIEKRCYPMIEPDPNVPERMIHRLLCLNCHLNRIGAVPATTASSLSLNHKPITSSMNSPFRLFTASSDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ98</accession>
    <name>A0A075AJ98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163329.1">
        <property type="nucleotide sequence ID" value="XM_009165065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ98"/>
    <dbReference type="GeneID" id="20326883"/>
    <dbReference type="KEGG" id="ovi:T265_12715"/>
    <dbReference type="CTD" id="20326883"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="777" mass="87182" checksum="8AE69B0F8BF79739" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJB4</accession>
    <name>A0A075AJB4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163166.1">
        <property type="nucleotide sequence ID" value="XM_009164902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJB4"/>
    <dbReference type="GeneID" id="20315175"/>
    <dbReference type="KEGG" id="ovi:T265_00987"/>
    <dbReference type="CTD" id="20315175"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="16742" checksum="109E4E281014CF02" modified="2014-10-01" version="1">METKDGKCPAGYQCCEKQIDAKNYLKAGTATARMEQLTGLFKLTSQHVRGELCELKAGNLLTQNLTTRPEIVKLLKRHCASSNREKQKRVVFPKESEATTLSITKLPHPAHPAFSSYGCPTMQPMEAATPSKAAKQGKPDHTSSRRARMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJV0</accession>
    <name>A0A075AJV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162181.1">
        <property type="nucleotide sequence ID" value="XM_009163917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJV0"/>
    <dbReference type="GeneID" id="20314397"/>
    <dbReference type="KEGG" id="ovi:T265_00209"/>
    <dbReference type="CTD" id="20314397"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="230" mass="25910" checksum="171344C736E92848" modified="2014-10-01" version="1">MHRKGDKHAGPRAIRSGEEVYVKLQSSANESVHECVTSTSQNLMDMLLGRTIRCNLDHIRTRKHGRDLEQTPELTAQVDSGLKQEFENSYRFSKVPTPISKGIKAGRTLLSWSWSNLAVTETAAATTTVQRTSIKLLKVYFECNACDTCLLLRKTSERPYELPGPWKVHATRWLLICSPSLAIDLQTFHHHSSRHLQCAHLQRRTEDVSLNGDETFANQLPSSANRSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVC6</accession>
    <name>A0A074YVC6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL598619">
        <property type="protein sequence ID" value="KER18696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177557.1">
        <property type="nucleotide sequence ID" value="XM_009179293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVC6"/>
    <dbReference type="GeneID" id="20330049"/>
    <dbReference type="KEGG" id="ovi:T265_15884"/>
    <dbReference type="CTD" id="20330049"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10695" checksum="1564DE96E51E5731" modified="2014-10-01" version="1" fragment="single">MDYRTHSACLLWPPYPTLPVIINSRVICVLIQADVFHAYQLVRKNNVPAKNIITFAYDDIASNPKNPFKGKVFHDYEHRDVYNGVEIDYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVK3</accession>
    <name>A0A074YVK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597900">
        <property type="protein sequence ID" value="KER18801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177452.1">
        <property type="nucleotide sequence ID" value="XM_009179188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVK3"/>
    <dbReference type="GeneID" id="20326317"/>
    <dbReference type="KEGG" id="ovi:T265_12149"/>
    <dbReference type="CTD" id="20326317"/>
    <dbReference type="OrthoDB" id="6286681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12711" checksum="E4B96A4DB7CD51DC" modified="2014-10-01" version="1">MSFATTIPPLQRKKFQRIASSPVPVVRGPLKAENVVSDQRLAYIPVRAKGTLVSSADEASKVWRADLKSSADGRELVIDSVDRASFDWMPNPGTVLPRLFIRVFNSVQLSWSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXF7</accession>
    <name>A0A074YXF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597238">
        <property type="protein sequence ID" value="KER19343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176913.1">
        <property type="nucleotide sequence ID" value="XM_009178649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXF7"/>
    <dbReference type="STRING" id="6198.A0A074YXF7"/>
    <dbReference type="GeneID" id="20326021"/>
    <dbReference type="KEGG" id="ovi:T265_11853"/>
    <dbReference type="CTD" id="20326021"/>
    <dbReference type="OrthoDB" id="10062030at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16766" checksum="379CB90F3C4333D0" modified="2014-10-01" version="1">MDFLVMHGAHIDAQAGTVRFSKSECNSTSSAPGITPRAPLQPIPVQGPNRRVGVDVIEPLTVTRKCNRFIVVMVDYLNKWCEAVPVKQQDARTITSVIISEWVSRRCVPVILHSDQGQAFESHLLWEIRAFLGIHKTRTIPYHPEGNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXS4</accession>
    <name>A0A074YXS4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597199">
        <property type="protein sequence ID" value="KER19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176779.1">
        <property type="nucleotide sequence ID" value="XM_009178515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXS4"/>
    <dbReference type="GeneID" id="20329693"/>
    <dbReference type="KEGG" id="ovi:T265_15528"/>
    <dbReference type="CTD" id="20329693"/>
    <dbReference type="OrthoDB" id="9979223at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="408" mass="45220" checksum="BA6D443D6A7E8D09" modified="2014-10-01" version="1" fragment="single">THVENVYLARYSSHGYGSGLPGGGSATFSNRKGTVNCTFAFLKLKPTAVCSTKHLDQLVHLYGLDKPATSSPTALCTRWLRKGGKEVIDTPYPAGRCQTAPRFNIPKASWDCQATKYVASYPKNKDRNTWPKTPQERAGLVVTYPGVSEARDKYAPPPKAVTEVFSNYGVLQQLQPGYRVNPHQDYHIKGWSPLPKREPTGSETTEYKLKFTWPSNKIPFADLGGASTQYAAYSCCATETSVPEGMKTLKLLGSEPYVKTVVTSTFQLLPHSSGLGTTNERYEFESVQIPIELNGLYKSFFKPRRPVDLVSFIIRTLDNRMLLHVHWTGFLLMCVNSLKRGSTGPSTVVELTFSLICSYFLLEPEATAASSAGVGIDLRHRNEGFLSESLTFDGRLYTVRLTAFVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY27</accession>
    <name>A0A074YY27_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL611818">
        <property type="protein sequence ID" value="KER18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178161.1">
        <property type="nucleotide sequence ID" value="XM_009179897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY27"/>
    <dbReference type="GeneID" id="20326548"/>
    <dbReference type="KEGG" id="ovi:T265_12380"/>
    <dbReference type="CTD" id="20326548"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9521" checksum="4D4BE993EDDAC40C" modified="2014-10-01" version="1">MPAIAKWRMWMWLSEGWATLGNGEKPRSLTHSRPEEASSAVPSARELVNQLRVTPSETDFLKTLPQISLSIPMIGHSEGASPVMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYV8</accession>
    <name>A0A074YYV8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597127">
        <property type="protein sequence ID" value="KER19853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176395.1">
        <property type="nucleotide sequence ID" value="XM_009178131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYV8"/>
    <dbReference type="STRING" id="6198.A0A074YYV8"/>
    <dbReference type="GeneID" id="20329608"/>
    <dbReference type="KEGG" id="ovi:T265_15443"/>
    <dbReference type="CTD" id="20329608"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="220" mass="24292" checksum="737658597EDFF930" modified="2014-10-01" version="1">MGDVNCDNMLILITVAQETNLKEREVAIPALMQVCSDVEFIMPNQTQEGVLLVLTKLLGTQVTLNNRQWILDGHIFWTSNLCNKCGASSESVSCCHYVYGSLNRTAARLMHKYGAHGCTDVIEPLRHPDNLARFQTNPTSGFKLHSLPVLAHMVEASCLLNVQTDCGIVPKILGSFVVLRAAAATQYCKELKELKCRPAWVVQSDTKKAFLVEGPSKQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Y3</accession>
    <name>A0A074Z0Y3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_15259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="KL597032">
        <property type="protein sequence ID" value="KER20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175574.1">
        <property type="nucleotide sequence ID" value="XM_009177310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Y3"/>
    <dbReference type="STRING" id="6198.A0A074Z0Y3"/>
    <dbReference type="GeneID" id="20329424"/>
    <dbReference type="KEGG" id="ovi:T265_15259"/>
    <dbReference type="CTD" id="20329424"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="181" mass="20340" checksum="4F355560E3BC99AB" modified="2014-10-01" version="1">MSLRSLSRRSALIDRIIRVDHAGELGANRIYQGQLFVLGKSSVGPIIKEMHDQEKAHLKKFESLIPRYRVRPTALLPFWNVAGLALGVGSALFGKKAAMACTVAVESVISEHYNSQIRELIEHDPAEYAELLQTLTKFRDEEIEHHDIGLAHEAEQAPAYQFFSQLVKMGCRASIFLAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1L5</accession>
    <name>A0A074Z1L5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597013">
        <property type="protein sequence ID" value="KER20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175375.1">
        <property type="nucleotide sequence ID" value="XM_009177111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1L5"/>
    <dbReference type="GeneID" id="20324830"/>
    <dbReference type="KEGG" id="ovi:T265_10662"/>
    <dbReference type="CTD" id="20324830"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="8919" checksum="24DC3F542D37A734" modified="2014-10-01" version="1">MPVANAASRTRQNIQDVTAAYTIDEAMCKCSRLFFSALIYVVHFWCRYSREAHPTHDWGTLAGLASGRDLIGGKTGPNSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1Q4</accession>
    <name>A0A074Z1Q4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597005">
        <property type="protein sequence ID" value="KER20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175273.1">
        <property type="nucleotide sequence ID" value="XM_009177009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1Q4"/>
    <dbReference type="GeneID" id="20324760"/>
    <dbReference type="KEGG" id="ovi:T265_10592"/>
    <dbReference type="CTD" id="20324760"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10908" checksum="C6E309F246F9EEB3" modified="2014-10-01" version="1">MTSVLNTDASLPYNHDLFESLIVKKRIKPTRQKSRGRGRVRTTDHPVSEFAFIMRRTLEDLENSGVQIVCDETYIEYADDIILIFEEERSRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2P9</accession>
    <name>A0A074Z2P9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597139">
        <property type="protein sequence ID" value="KER19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176464.1">
        <property type="nucleotide sequence ID" value="XM_009178200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2P9"/>
    <dbReference type="GeneID" id="20325690"/>
    <dbReference type="KEGG" id="ovi:T265_11522"/>
    <dbReference type="CTD" id="20325690"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="13238" checksum="47B866506239F5F3" modified="2014-10-01" version="1">MVDDRTWSSPQNPNLLPTREGQITVDQCKEMSLRCSQPRDKDALSNQCFPSEKSFRRIRWSSVDVQQWCCSQDRKTDTYNLWSSMAGCSQNTTYFDQEMRVCHQMIRAANQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2W7</accession>
    <name>A0A074Z2W7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596974">
        <property type="protein sequence ID" value="KER21338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174909.1">
        <property type="nucleotide sequence ID" value="XM_009176645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2W7"/>
    <dbReference type="GeneID" id="20324479"/>
    <dbReference type="KEGG" id="ovi:T265_10311"/>
    <dbReference type="CTD" id="20324479"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="18090" checksum="F329722078F0BAA6" modified="2014-10-01" version="1">MGTAWSVPNILKWCSFFVDTVIPSETLQRNTDMHNYKLFPEAMNNFHRVFYGLGFLRKFNREPEAMEPNAKWRSGQWNTSRSFGIDSANWHWPTGSAHPRVLRLSFRAPQHRLLAVVLPQLLPQVVQVPQMTARLQVPPLASLQAELQLLALPDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z343</accession>
    <name>A0A074Z343_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174765.1">
        <property type="nucleotide sequence ID" value="XM_009176501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z343"/>
    <dbReference type="GeneID" id="20329246"/>
    <dbReference type="KEGG" id="ovi:T265_15080"/>
    <dbReference type="CTD" id="20329246"/>
    <dbReference type="OrthoDB" id="6262973at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="17222" checksum="D965DFE7EA476A9C" modified="2014-10-01" version="1" fragment="single">KVFQAWSGYVRQKHGRILSLIEKVRNETLIRSFFQRLHLVVQKARETENQAFAWHEQQLMRRVLSGWSTHVTSLLIWDWKLEDVARAHREDVLKRRVLSAWITIPSLMREERERERRRELLREKLRDLVPDFSPPQLREGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z491</accession>
    <name>A0A074Z491_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174383.1">
        <property type="nucleotide sequence ID" value="XM_009176119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z491"/>
    <dbReference type="GeneID" id="20324073"/>
    <dbReference type="KEGG" id="ovi:T265_09905"/>
    <dbReference type="CTD" id="20324073"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="157" mass="18137" checksum="380E563083FF8479" modified="2014-10-01" version="1">MPPIRAKFHRKDPQSSPLLTKKMVTVALSNGAAFWQRWNQYRAEIHKFLSVKQCQIWAAVRQMKHVLHICRVVGTKVHGGDGHIISSSADRVKWKRSMLSGGTRIRYRQIYPLPINLFFTGDSSEPLVYDILQLNVPHKGRLMLQSAQHSRYRSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z557</accession>
    <name>A0A074Z557_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SF3 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_16044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601129">
        <property type="protein sequence ID" value="KER18455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177798.1">
        <property type="nucleotide sequence ID" value="XM_009179534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z557"/>
    <dbReference type="GeneID" id="20330209"/>
    <dbReference type="KEGG" id="ovi:T265_16044"/>
    <dbReference type="CTD" id="20330209"/>
    <dbReference type="OrthoDB" id="8300295at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER18455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="15993" checksum="636AACC3A7DB25A2" modified="2014-10-01" version="1" fragment="single">MNKLCTRKNAFVIEGPTTTGKTLFVKLVAENYVYGTVQRSGDHSQFFLMNLLNKTLALMEEPRITQLTVNDFKELLGGNAFDIHVKHQKDERLDRLPVLITTNNPLTYYVMDADGKAILERCFYFKFHVKVGSPDLPEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5B3</accession>
    <name>A0A074Z5B3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600544">
        <property type="protein sequence ID" value="KER18505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177748.1">
        <property type="nucleotide sequence ID" value="XM_009179484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5B3"/>
    <dbReference type="STRING" id="6198.A0A074Z5B3"/>
    <dbReference type="GeneID" id="20330177"/>
    <dbReference type="KEGG" id="ovi:T265_16012"/>
    <dbReference type="CTD" id="20330177"/>
    <dbReference type="OrthoDB" id="3549872at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11493" checksum="A6417E48F1B19AB2" modified="2014-10-01" version="1" fragment="single">EGLSTQTTNPSDEISLDRFFHLAGVEPSQLEAIYSGDFGDLTGTGGVYSGPSKPDSSSITLSSQYQMGTDPRSKAEEEAASYRRKLAAYQDGQQKQAQLIQKLQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5P2</accession>
    <name>A0A074Z5P2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597015">
        <property type="protein sequence ID" value="KER20852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175397.1">
        <property type="nucleotide sequence ID" value="XM_009177133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5P2"/>
    <dbReference type="STRING" id="6198.A0A074Z5P2"/>
    <dbReference type="GeneID" id="20324847"/>
    <dbReference type="KEGG" id="ovi:T265_10679"/>
    <dbReference type="CTD" id="20324847"/>
    <dbReference type="OrthoDB" id="419198at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="352" mass="40614" checksum="E480A8D270EEE543" modified="2014-10-01" version="1">MTWDDLKPNCQLPQSLGAERFLVRPTCTHEYLRLLPNLSRLEWPIANYAPQPQGLKLPDGRVYRNPTPFDPVMSRGQRALSKRLLCVITNLLYANKMADRFFLTGATLLGSLRHHDFIPYDDDVDILLDETVKPIVQNLTGFLEPEYMVYWGSDRAKFFTRPVAPQEEHQDVEHSRHLSQHPWNWPYVDIGYYNVNSTHVYEVAEWMGRKLVWPRSVVFPLLYRPLGINWFPTPYNSIGFIRQAVGIVANCTASGYSHSFEGGEKPGNRPCIELAGRYPFVEHQTMRDGPRVRMQDQRSKDKVSTELVKSQESLVILQNQSSTKHLIHELVLYTHADVATLDTYDYGKNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5Q0</accession>
    <name>A0A074Z5Q0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173771.1">
        <property type="nucleotide sequence ID" value="XM_009175507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5Q0"/>
    <dbReference type="GeneID" id="20323609"/>
    <dbReference type="KEGG" id="ovi:T265_09440"/>
    <dbReference type="CTD" id="20323609"/>
    <dbReference type="OrthoDB" id="6240738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="375" mass="41909" checksum="CF0EDA4B125948DC" modified="2014-10-01" version="1">MLRFIPCLSSKATQCLLISNFQFQVYDGIAVRMKEEFASYESHKANNSGSIVSGFLMTAVSWKRPLFGLWFDSVTHEKISGNVGSYFIVETPTINLIRPEGHTSLQGNVKDVPSMTQSGKPLHDTVGPIFDILQYIFIKETAHKVAETSSKPTTGFALLRAHQVGAVSEFPSNLCSNLTRIGLFLRSTFIRKSIWFSRETQLNLSFMIIYKCAYLMSPMKSETGPVMGGAEQMFVFETFFTNVPTLVNFTRAVKSDNFVAIITTIDSLFLLSSASYGLWVYGHIKPQILVESLLCFAISIFVYVAALKAPIECCKMIEPDLKSGCPNQFIRTNSYFFNGCESNLRQYLHEHIPVIVYASLSVLPLDALDVARAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6E4</accession>
    <name>A0A074Z6E4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597856">
        <property type="protein sequence ID" value="KER18815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177437.1">
        <property type="nucleotide sequence ID" value="XM_009179173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6E4"/>
    <dbReference type="GeneID" id="20329974"/>
    <dbReference type="KEGG" id="ovi:T265_15809"/>
    <dbReference type="CTD" id="20329974"/>
    <dbReference type="OrthoDB" id="6291661at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12291" checksum="FCC9B0726962D65B" modified="2014-10-01" version="1" fragment="single">MGQTSTKANGYYTWSQNQSSLRGDKVVCQQRLTRERVDSDEPDRRHYGAVKDKQIFSSTKRALTNWIVEEAPNYIVRVRSANKGKGYKDVHADLMSRESGTIQNENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7K1</accession>
    <name>A0A074Z7K1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_08944</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173151.1">
        <property type="nucleotide sequence ID" value="XM_009174887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7K1"/>
    <dbReference type="STRING" id="6198.A0A074Z7K1"/>
    <dbReference type="GeneID" id="20323123"/>
    <dbReference type="KEGG" id="ovi:T265_08944"/>
    <dbReference type="CTD" id="20323123"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="16">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER23088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="613" mass="69679" checksum="2672502B234588AB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7R6</accession>
    <name>A0A074Z7R6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08839</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173015.1">
        <property type="nucleotide sequence ID" value="XM_009174751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7R6"/>
    <dbReference type="STRING" id="6198.A0A074Z7R6"/>
    <dbReference type="GeneID" id="20323018"/>
    <dbReference type="KEGG" id="ovi:T265_08839"/>
    <dbReference type="CTD" id="20323018"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF102">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="601" mass="67601" checksum="F7DA765171161565" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7X4</accession>
    <name>A0A074Z7X4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_15569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597237">
        <property type="protein sequence ID" value="KER19345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176902.1">
        <property type="nucleotide sequence ID" value="XM_009178638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7X4"/>
    <dbReference type="STRING" id="6198.A0A074Z7X4"/>
    <dbReference type="GeneID" id="20329734"/>
    <dbReference type="KEGG" id="ovi:T265_15569"/>
    <dbReference type="CTD" id="20329734"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10372" checksum="2F5A82862C79069B" modified="2014-10-01" version="1">MPERKAVVKNADMDENMQQDAVDLCNQAMLKFTMEKDIAAFIKKEFDKRYNPTWHCIVGRAFGSYVTHETRHFIYFYLGSNAVLLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8H5</accession>
    <name>A0A074Z8H5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174387.1">
        <property type="nucleotide sequence ID" value="XM_009176123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8H5"/>
    <dbReference type="GeneID" id="20324075"/>
    <dbReference type="KEGG" id="ovi:T265_09907"/>
    <dbReference type="CTD" id="20324075"/>
    <dbReference type="OrthoDB" id="10445454at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7875" checksum="514D825453DA309F" modified="2014-10-01" version="1">MLPAFLSVGRVCDSSLNLEKYTHLQISLVFTRDSTESLVYDVLQLNALHTGRLMFQLVRYSRYCNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z979</accession>
    <name>A0A074Z979_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596835">
        <property type="protein sequence ID" value="KER23781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172465.1">
        <property type="nucleotide sequence ID" value="XM_009174201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z979"/>
    <dbReference type="GeneID" id="20322584"/>
    <dbReference type="KEGG" id="ovi:T265_08405"/>
    <dbReference type="CTD" id="20322584"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="74"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122344" checksum="D0936878B494A0E8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9A4</accession>
    <name>A0A074Z9A4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stabilizer of axonemal microtubules 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176424.1">
        <property type="nucleotide sequence ID" value="XM_009178160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9A4"/>
    <dbReference type="STRING" id="6198.A0A074Z9A4"/>
    <dbReference type="GeneID" id="20325659"/>
    <dbReference type="KEGG" id="ovi:T265_11491"/>
    <dbReference type="CTD" id="20325659"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05217">
        <property type="entry name" value="SAXO1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="53261" checksum="8DDB587BF9EDC4E0" modified="2014-10-01" version="1">MGHRGTQCICEICCCGRHKCPHRPKAIEPWGPCVMSEYTAQYHPQCVEPNKVIVPPSNIFASGDPMSGKTTHRNDYVPHPYERPYVQKPIPYKAPCGKMEDSTLYRNEYTAKNCAPSLPVKPLERRMCSAKFDGQPTYRSDYRSWDLPPMRPQKPKQERPNLPKFDAEPVYRREFVPKCIEKLKSYKPENRPTPDEPFRSDTMYRTEYVPRQVEPPAPIKPALYAKSKMPFETLTTNRKDFTPKEMCPNRPFKPQNLLFASADPMSKATTNRTDYKDWGPSYPERGAKPEYKPLEGDQSFDSTYRNDFNEKPICPVVNVKPFEPKRCDAKFDDLTNYRHEYKQWEVPPPKPAKKDEWAPSDAPFDDSTTNRVSYVPHPCVVAPQPITPKPQSWYSGPFDDRTNYRTEYVPKEVCPCCPAGFLPTDDVSPDGYVFDHFDERGHQIYRNVTGDKNTLPLLPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9C7</accession>
    <name>A0A074Z9C7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172440.1">
        <property type="nucleotide sequence ID" value="XM_009174176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9C7"/>
    <dbReference type="STRING" id="6198.A0A074Z9C7"/>
    <dbReference type="GeneID" id="20328727"/>
    <dbReference type="KEGG" id="ovi:T265_14561"/>
    <dbReference type="CTD" id="20328727"/>
    <dbReference type="OrthoDB" id="10259713at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="8">
        <location>
            <begin position="131"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="37464" checksum="D27FEC10E72F10BA" modified="2014-10-01" version="1" fragment="single">LVQQVSDVGEAGRIRSKTRNEVADRILRLSWEQKVTVLQSEQEAYKQEIIALEKSSEALLHNYRAELEALVVIQKEINKSSNEFSKIFVTTGCGKLVNPIYYEKFLKFIQDSTRQRLSLAQNIFVPLFNYKDTIVDKLRLKNSALHTQLRKSREQLRQKEELGEVLRPVDFEQLKIDNSECLRKIDERNQEIQRLKLVAGKTLQVLNAYKVQLTQAIKEKERIKLEIAQRLDIKRRAQSEMVAVKKELKEETKANKEFKEHTLSYNVPSVITLMKLKSEEREIVRKESIHKRKLHLAQMALARHKKIWLRIRHSTADAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9H7</accession>
    <name>A0A074Z9H7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596836">
        <property type="protein sequence ID" value="KER23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172479.1">
        <property type="nucleotide sequence ID" value="XM_009174215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9H7"/>
    <dbReference type="GeneID" id="20322595"/>
    <dbReference type="KEGG" id="ovi:T265_08416"/>
    <dbReference type="CTD" id="20322595"/>
    <dbReference type="OrthoDB" id="6273764at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12945" checksum="3F9F74A20E404C0F" modified="2014-10-01" version="1">MHAMEAPGDSDSPKAGVHDNFCGWKTETKVISQSPDFNRTAAPLYDFLGRNRKFEWTRGREASERVKARKLDQQLTLKLPRIGGMFIVAEGASDRGIGAVLKHRNGVIEYASRVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9K8</accession>
    <name>A0A074Z9K8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596834">
        <property type="protein sequence ID" value="KER23798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172445.1">
        <property type="nucleotide sequence ID" value="XM_009174181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9K8"/>
    <dbReference type="GeneID" id="20322566"/>
    <dbReference type="KEGG" id="ovi:T265_08387"/>
    <dbReference type="CTD" id="20322566"/>
    <dbReference type="OrthoDB" id="6242357at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="716"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="793" mass="91781" checksum="446B2ACD4919B14F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA18</accession>
    <name>A0A074ZA18_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596899">
        <property type="protein sequence ID" value="KER22427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173827.1">
        <property type="nucleotide sequence ID" value="XM_009175563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA18"/>
    <dbReference type="STRING" id="6198.A0A074ZA18"/>
    <dbReference type="GeneID" id="20329024"/>
    <dbReference type="KEGG" id="ovi:T265_14858"/>
    <dbReference type="CTD" id="20329024"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902749">
        <property type="term" value="P:regulation of cell cycle G2/M phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF92">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="164"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER22427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="759" mass="86346" checksum="601D92CC26C5D636" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA60</accession>
    <name>A0A074ZA60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172120.1">
        <property type="nucleotide sequence ID" value="XM_009173856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA60"/>
    <dbReference type="GeneID" id="20328648"/>
    <dbReference type="KEGG" id="ovi:T265_14482"/>
    <dbReference type="CTD" id="20328648"/>
    <dbReference type="OrthoDB" id="6269477at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="386" mass="43415" checksum="05DAA0F456D97C7D" modified="2014-10-01" version="1" fragment="single">MADGSGEPTIEQLGDLLIRMGLSPRYEGNCPMEQRNATESLPKLCVPGYHQCVARASIPYLVSALTAEHLQLQLEDSAPASDRVKLIAAMLIAHYSLLSMYLEDDQLWTDGNFELVYEEPAERQIHRVACLMNGRAKNMLDCVLQLIVITKLWWWQSGSNERVPGAKYRRLLAACELDLTKDLETILCVGHWASTLRILSLRGIATRDHFVLWKPLGDEALVKTLVVKTVGLPVGVCHLTFCAYVFRLFLQAIPRDYDIPLSILQIMSDTVDAYTTYEANPAVFHPDPRHLTGVNDLKEWHDECARAPLGLALPIVRKCFRLSTEASCVFNRIPEELDSQLAFYSASFSDWCQSHGRRTIELCANSEEQLCFYGLSVGDTLSTIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAB2</accession>
    <name>A0A074ZAB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596819">
        <property type="protein sequence ID" value="KER24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172053.1">
        <property type="nucleotide sequence ID" value="XM_009173789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAB2"/>
    <dbReference type="GeneID" id="20322269"/>
    <dbReference type="KEGG" id="ovi:T265_08090"/>
    <dbReference type="CTD" id="20322269"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13157">
        <property type="entry name" value="PTB_tensin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="628"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="89944" checksum="FB79222F6BF958F8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAR1</accession>
    <name>A0A074ZAR1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597068">
        <property type="protein sequence ID" value="KER20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175931.1">
        <property type="nucleotide sequence ID" value="XM_009177667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAR1"/>
    <dbReference type="GeneID" id="20325270"/>
    <dbReference type="KEGG" id="ovi:T265_11102"/>
    <dbReference type="CTD" id="20325270"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10066" checksum="2A58AF9A575E16C8" modified="2014-10-01" version="1">MQFHSFGVSLTTLLQSRSELYPDHLSTIITRAILGSFSVISVRFLRQGSTGEQRRSLQMYAIGAPWAHQASAAKPSILEERTFKIIDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAR3</accession>
    <name>A0A074ZAR3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171854.1">
        <property type="nucleotide sequence ID" value="XM_009173590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAR3"/>
    <dbReference type="STRING" id="6198.A0A074ZAR3"/>
    <dbReference type="GeneID" id="20328594"/>
    <dbReference type="KEGG" id="ovi:T265_14428"/>
    <dbReference type="CTD" id="20328594"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="175"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57633" checksum="0B2EE5097B005957" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAS2</accession>
    <name>A0A074ZAS2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171845.1">
        <property type="nucleotide sequence ID" value="XM_009173581.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZAS2"/>
    <dbReference type="GeneID" id="20322100"/>
    <dbReference type="KEGG" id="ovi:T265_07921"/>
    <dbReference type="CTD" id="20322100"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001384">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="5270"/>
            <end position="5463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4551"/>
            <end position="4596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4611"/>
            <end position="5133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4612"/>
            <end position="4625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4626"/>
            <end position="4636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4652"/>
            <end position="4666"/>
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            <end position="4742"/>
        </location>
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            <begin position="4750"/>
            <end position="4759"/>
        </location>
    </feature>
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            <begin position="4797"/>
            <end position="4823"/>
        </location>
    </feature>
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        <location>
            <begin position="4863"/>
            <end position="4873"/>
        </location>
    </feature>
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        <location>
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            <end position="4936"/>
        </location>
    </feature>
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        <location>
            <begin position="4950"/>
            <end position="4960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <end position="5078"/>
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            <end position="5123"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER24406.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="5475" mass="610254" checksum="83E221BABF55714E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER24596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="ovi:T265_09107"/>
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    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER22902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16608" checksum="C782B70F762136A9" modified="2014-10-01" version="1">MGQGRQIGDEHCNKLFVPSCHATRLKHNGWNTASLPKPKQEKSRCRNRARTKDLPGKFALLDECSSPIAEEIIQLSVWRRRSGEVQLHFRAFRPKKVLISIEPEYTFRPSSDHNNVQLWRPFGAYLLFHLKGAPALRYCQVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDL0</accession>
    <name>A0A074ZDL0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hepatocyte growth factor-regulated tyrosine kinase substrate helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZDL0"/>
    <dbReference type="GeneID" id="20322647"/>
    <dbReference type="KEGG" id="ovi:T265_08468"/>
    <dbReference type="CTD" id="20322647"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
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        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="303"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="486" mass="54246" checksum="B861A5F077E94036" modified="2014-10-01" version="1">MPLKPHKKSRSKAVSHPNQEKPAKEKKPQPNRDEQARRDQERKERELEARENEELELALALSASEAESKERERRALQRAPQKTTEPPVDTIGPAENGPLKLLPVLDTSDMDPELARYLNRHYWENRAASSNQLTNKSALDDPHTSPGPQPSAPIYSSPIPTPVKTGNPSGPGVVQTNGLLQSGNDNNTVFESESTFPGVPELTTPKQEEFLNALRASVEFFVNRMQSNSQRGRSIANDTTVQALFLTLHEMHPQLLQYKQAMEERRAYFEGLQDKITQLRDAREALDALRQEHAARRQLEEQEAARLRQLQMMQKLEVMRQQKRDTLEYRRRLAMEQTMQYQQQYQLPPQSMQHSMDPVTGMPITMPIGPYPGGYQIPNPSYSMAGPTQGMYIPPSMEASLPAPQAGTDPSSMYPSAAAAHTPGQHPSANTIAAEDPSTVQPPSYSQLPDRPAEDSQPATSTGNYPSTGYSQPQAALLEGQLISFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE98</accession>
    <name>A0A074ZE98_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172298.1">
        <property type="nucleotide sequence ID" value="XM_009174034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE98"/>
    <dbReference type="GeneID" id="20328687"/>
    <dbReference type="KEGG" id="ovi:T265_14521"/>
    <dbReference type="CTD" id="20328687"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="185" mass="20790" checksum="EBA043C54823B603" modified="2014-10-01" version="1">MYDLSIATDDNLFAGSCFRPGVPGAEILANFLPNFKLTRQMGGQVGTPRTEMRPCPSGLLASTQLQHFAMHFGFKLHNVAPPPSFQRHLPYSPAGRRSVLCTFFYRRATQDHTVNYPEGFGVYREWCLKKPRSRAENSGDTRALQMGTSLTRHTQTCHTTSLPPEKYYLKARGSAELGTPVMTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEA3</accession>
    <name>A0A074ZEA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172300.1">
        <property type="nucleotide sequence ID" value="XM_009174036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEA3"/>
    <dbReference type="GeneID" id="20328689"/>
    <dbReference type="KEGG" id="ovi:T265_14523"/>
    <dbReference type="CTD" id="20328689"/>
    <dbReference type="OrthoDB" id="10569531at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20623" checksum="D30113381AAA5B32" modified="2014-10-01" version="1" fragment="single">MQRVTASHQSQTARVSVDQGQTTPPQYAARRCLVLKPDSVRQHWTKFTRCPSNKKLEAVVLLTLARTRALATTLLEYSYCVPFRACFNLKNSITSDDRPSPPEILSLEVNIQKRMANVSWAVSPNAAHFLVNFYVSTDVTCTTTTVSLQLTFGNIPVCKQLRVGVSAENEAGLSNESLSPEFYIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEX2</accession>
    <name>A0A074ZEX2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596768">
        <property type="protein sequence ID" value="KER25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170550.1">
        <property type="nucleotide sequence ID" value="XM_009172286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEX2"/>
    <dbReference type="STRING" id="6198.A0A074ZEX2"/>
    <dbReference type="GeneID" id="20321077"/>
    <dbReference type="KEGG" id="ovi:T265_06898"/>
    <dbReference type="CTD" id="20321077"/>
    <dbReference type="OrthoDB" id="6278006at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23426" checksum="30C0B6179A8D875D" modified="2014-10-01" version="1">MAGRAHKLKFERDVALARCLLIYGTNIQASIGQTPSFMTTGQGMRLPSDTTLPISAPEALYSSVFVRRMQAGLVRSHELARQRLRAAQRCQKGYYDKAAQDMLFNLGDWVWLYEPVPPTGTPAKFHGAWKGPYTIDQAVTDVTYRLIHPGKSNWSTAVNVNRLLSAQLISDSAVDSACCERACVMCRQMSNCAPSLITISFVYFQKRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF88</accession>
    <name>A0A074ZF88_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170300.1">
        <property type="nucleotide sequence ID" value="XM_009172036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF88"/>
    <dbReference type="GeneID" id="20320881"/>
    <dbReference type="KEGG" id="ovi:T265_06702"/>
    <dbReference type="CTD" id="20320881"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8344" checksum="181761CF2B9B2A94" modified="2014-10-01" version="1">MCLLHQYTDNIEWLDIAPNVSLMDSRLSLLESKTNPDSRGYCGVDEQMAGFIHIGVTSNLIQKKDALTPNSEVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFQ9</accession>
    <name>A0A074ZFQ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="1">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171751.1">
        <property type="nucleotide sequence ID" value="XM_009173487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFQ9"/>
    <dbReference type="STRING" id="6198.A0A074ZFQ9"/>
    <dbReference type="GeneID" id="20322026"/>
    <dbReference type="KEGG" id="ovi:T265_07847"/>
    <dbReference type="CTD" id="20322026"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="739" mass="82944" checksum="FD1BE74B1AF84FB7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFR7</accession>
    <name>A0A074ZFR7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L41, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174162.1">
        <property type="nucleotide sequence ID" value="XM_009175898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFR7"/>
    <dbReference type="STRING" id="6198.A0A074ZFR7"/>
    <dbReference type="GeneID" id="20323901"/>
    <dbReference type="KEGG" id="ovi:T265_09733"/>
    <dbReference type="CTD" id="20323901"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="20503" checksum="15491ED7A7DFF432" modified="2014-10-01" version="1">MWHLRWNWTIDCTRRYISTSGPLHFRQKLAYKTRYHWLLDVQKSRQRARFPWIPREPPTAVNIDDQRIEFPEMQLDFIVPTDLNQCELKPYVDWRASTPKEDELTADKLFDKKYIPKIQNMYERGIDKSEIIKKVTNYLAFYSLCITRHDISPSSQRDGFRISIFTRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFT7</accession>
    <name>A0A074ZFT7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170128.1">
        <property type="nucleotide sequence ID" value="XM_009171864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFT7"/>
    <dbReference type="GeneID" id="20328232"/>
    <dbReference type="KEGG" id="ovi:T265_14066"/>
    <dbReference type="CTD" id="20328232"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="234" mass="26162" checksum="18AD1A895729E7EA" modified="2014-10-01" version="1">MGTGLMSSSEESIPWKRHLKVPVMKPTVFDLEFHFACKQLAVSQLSCSLRVAWQLGTERASQPNHMENVSKICHRSSGNTFACSNVIIQMRPTCVGGVVVTRSPRMSGSYPGTDIGYALLMSSNKSEARVQCSPLVWTHWSNYARTGTRPFERDWCDYEHVIGTECTFAYLDGIQTWRRSVVISQMLRTIGLSARHQMSEPAVPPVLNRITIVAASLYYCTESLYSVVVCLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGZ7</accession>
    <name>A0A074ZGZ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169755.1">
        <property type="nucleotide sequence ID" value="XM_009171491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGZ7"/>
    <dbReference type="GeneID" id="20320453"/>
    <dbReference type="KEGG" id="ovi:T265_06271"/>
    <dbReference type="CTD" id="20320453"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8121" checksum="C94EB304A4062A2C" modified="2014-10-01" version="1">MPPLPRRVIRKACQRVLESDAVMSAYVIECIARNSSNPEDEVLYKKGQPIDQFRAAANVKIALIRIGDSAHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHY1</accession>
    <name>A0A074ZHY1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169372.1">
        <property type="nucleotide sequence ID" value="XM_009171108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHY1"/>
    <dbReference type="STRING" id="6198.A0A074ZHY1"/>
    <dbReference type="GeneID" id="20320143"/>
    <dbReference type="KEGG" id="ovi:T265_05961"/>
    <dbReference type="CTD" id="20320143"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="220"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="57616" checksum="96478DA987AFB690" modified="2014-10-01" version="1">MNKVTCCPCYTIRCDAAKFRPSRSHKRLLKAVALFLTTGVMPKLFGRSGNQWRAESLSEVPNHTNPATLGARGDIPNTEYAGSQEADSRTSATSARFDCSQTTSPEVDTFSTFVIPAGDVQDTSKRSSTVPKLTKAHTRRWNARLARMKARALNENRPFELLLKEYEERRRRRLAKNAPKELEYFLAQEPNKGQGKHHIEIRLVRSSPSSNEFNSTLDTSYQLYKKYQVTVHGDKPDECTMGCFTRFLVKSPLVTFGSSLDVQYTPKSDDAGDSPNTSSVPSMGSYHQQYWLDGVRLIAVGVIDILPRCLSSVYLYYDPDYSFLHLGTYSALRELGFVRDLIRTHGLTSVTPHPLYVHFDSYYMGYYIRSCPKMSYKAQFHPSYLACPETYIWVPVKSCLQRLDSAPGGKYARFSDESATDVHAISEPLDPVDLDRKIVCRISSNDRRRRRERLPPEPEDDKRFGVPVTLDFLRRHITPEGLQIFREWAKLLGRRALDGNFQIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIA5</accession>
    <name>A0A074ZIA5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170734.1">
        <property type="nucleotide sequence ID" value="XM_009172470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIA5"/>
    <dbReference type="STRING" id="6198.A0A074ZIA5"/>
    <dbReference type="GeneID" id="20321225"/>
    <dbReference type="KEGG" id="ovi:T265_07046"/>
    <dbReference type="CTD" id="20321225"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="638" mass="72537" checksum="C080D010749FD655" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ70</accession>
    <name>A0A074ZJ70_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation channel complex component UNC80 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168886.1">
        <property type="nucleotide sequence ID" value="XM_009170622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ70"/>
    <dbReference type="STRING" id="6198.A0A074ZJ70"/>
    <dbReference type="GeneID" id="20327977"/>
    <dbReference type="KEGG" id="ovi:T265_13810"/>
    <dbReference type="CTD" id="20327977"/>
    <dbReference type="OrthoDB" id="5584001at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="610" mass="67949" checksum="408AB5296F645DA0" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKV9</accession>
    <name>A0A074ZKV9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168642.1">
        <property type="nucleotide sequence ID" value="XM_009170378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKV9"/>
    <dbReference type="STRING" id="6198.A0A074ZKV9"/>
    <dbReference type="GeneID" id="20327928"/>
    <dbReference type="KEGG" id="ovi:T265_13761"/>
    <dbReference type="CTD" id="20327928"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29335" checksum="EE242E2198BAE1F5" modified="2014-10-01" version="1" fragment="single">SICVRNLSEARTPFCTSIHPVSHVSEIERNCQHRYSNAVLPSTYIYQLPCCRQRRLQEPIFRFVRLSLVFTLGLSAPIKKFYKNVTISQVIPEGEQDLVYEVQLDKRKLRTPGGNTLLIPNEALALAVAVEWDSQKGTIKRHSMHLTNLCNRVLDWRSEIKPLDVVQSIMQYADTDTICFRVQEPDDLVHLQNASWDPVLHWVAEHYRIQPYLTNSLTGTPVMSSADRDILKQNLLGNTRWALIGKLHGYLLSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL43</accession>
    <name>A0A074ZL43_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_05267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168500.1">
        <property type="nucleotide sequence ID" value="XM_009170236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL43"/>
    <dbReference type="GeneID" id="20319449"/>
    <dbReference type="KEGG" id="ovi:T265_05267"/>
    <dbReference type="CTD" id="20319449"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705461" description="Cadherin domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="139"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="245"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="373"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="485"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="633"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="743"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER27781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138828" checksum="338132BE3C229A07" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL62</accession>
    <name>A0A074ZL62_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596823">
        <property type="protein sequence ID" value="KER24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172171.1">
        <property type="nucleotide sequence ID" value="XM_009173907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL62"/>
    <dbReference type="STRING" id="6198.A0A074ZL62"/>
    <dbReference type="GeneID" id="20322361"/>
    <dbReference type="KEGG" id="ovi:T265_08182"/>
    <dbReference type="CTD" id="20322361"/>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="344" mass="38963" checksum="BF8E8377B6858230" modified="2014-10-01" version="1">MTMEDSLAASNAGGAEVPPGRPLTDTEYADDIAPFVSGPVLPIATSSQYKYGQIMLLHLNVPTVRPPWKIQQFFWRSFRVAGRSNKGAEEDKNTTEYVHSADYLSAFISKDKTQDTAESKVSNLLYFSQTAFFSELLGMFVDSAEEPYRLPEPPKLNLFVRDSSSLKACTETSAEEMSKCPVFDSLEVLELSLLSSIPLNQFDEWLQWTQEGKMWRFPIDNEQGTTLQLTKSAGVVAVGDMNRLSFFPFSSLLPADWEEVSVPFYEHTFLEKHLDKELLKCGPLSVFLELVCHGLAQNPHFTVEQKREHLKWYSSYFKDKVSAIEASVQEEKRLTELEQKARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLK1</accession>
    <name>A0A074ZLK1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172029.1">
        <property type="nucleotide sequence ID" value="XM_009173765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLK1"/>
    <dbReference type="GeneID" id="20322249"/>
    <dbReference type="KEGG" id="ovi:T265_08070"/>
    <dbReference type="CTD" id="20322249"/>
    <dbReference type="OrthoDB" id="425619at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13692" checksum="4783DAA687917846" modified="2014-10-01" version="1">MKRVTALYQTQTARVSVDQGQIRQPQYATRRSQIEVYWPVMRSEVVDYVFCKWCQLMKGDTTGATHPMVPTVVSEISELWSVDIKGPFLMGISRNQYIVIMPEHLSRWTDAATVPNQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMP6</accession>
    <name>A0A074ZMP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitinase II/V-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169178.1">
        <property type="nucleotide sequence ID" value="XM_009170914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMP6"/>
    <dbReference type="STRING" id="6198.A0A074ZMP6"/>
    <dbReference type="GeneID" id="20319989"/>
    <dbReference type="KEGG" id="ovi:T265_05807"/>
    <dbReference type="CTD" id="20319989"/>
    <dbReference type="OrthoDB" id="10254444at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066:SF2">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitinase II/V-like catalytic" evidence="2">
        <location>
            <begin position="54"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="38482" checksum="D92FD8DFE2C43090" modified="2014-10-01" version="1">MNLHSVLLFELPLSTRTPTARTPTVSTTKVDLDEFLDSFSSYNMYTVTQKATNGSVLAYVTPWNKRGFELAETFASKFTLISPVWFQVLGRKKAYSVTGLPEVNKDWMARLKSINPSIKIVPRFDFREWQASDFADTLGDRSAAEQCLANVLRILKHYELDGAVIELWSFFVGAPEESLHNFIELIGQSLRDINMVTVLVIPPPVYRGPGPNSPINWVEKCILHLVPHGSHKAAEKRAQILTGFNFYGLHHIPERRFGDYILGHQFVHIVNQSRADFIWDSTASEHYLKFRDENGHENFVYYPTVASISRRIDLVEHLGTGISIWEIGQGLDSFFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMR1</accession>
    <name>A0A074ZMR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_13580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167837.1">
        <property type="nucleotide sequence ID" value="XM_009169573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMR1"/>
    <dbReference type="STRING" id="6198.A0A074ZMR1"/>
    <dbReference type="GeneID" id="20327747"/>
    <dbReference type="KEGG" id="ovi:T265_13580"/>
    <dbReference type="CTD" id="20327747"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="316" mass="35102" checksum="4B037FD298DEEA85" modified="2014-10-01" version="1" fragment="single">MPYRHRKDYSFAISLLKVFVVVSSSGHFLQKIFHSFLFQFRTSALLFFRPSVLKLPVLTNRSSMISYLNQADAQQLDNELFTEYAYSVDQLMELAGLSCATAIAKAYPRDKLRITNGALLVCCGPGNNGGDGLVCARHLKMFMASQWGSSYNLIVDALFGFGFKPPVSAEFRTLLDYMCQAKIPVVSIDVPSGWNVEADVGEVEEGSLNPDCLISLTAPKLCARAFRGRFHFLGEVEPWTVNVEPPTASEVYDCICSLKRHRAPGPDDLPPALFKDGGEVLSQRLSDLFACIWETESVPDNWGESVIVPISKKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN20</accession>
    <name>A0A074ZN20_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14352</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171538.1">
        <property type="nucleotide sequence ID" value="XM_009173274.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZN20"/>
    <dbReference type="GeneID" id="20328518"/>
    <dbReference type="KEGG" id="ovi:T265_14352"/>
    <dbReference type="CTD" id="20328518"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="743"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="804"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="591"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="839"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1361"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER24725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1971" mass="212137" checksum="939D1FCCD7E416CC" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPP9</accession>
    <name>A0A074ZPP9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168501.1">
        <property type="nucleotide sequence ID" value="XM_009170237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPP9"/>
    <dbReference type="GeneID" id="20319450"/>
    <dbReference type="KEGG" id="ovi:T265_05268"/>
    <dbReference type="CTD" id="20319450"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="199" mass="22092" checksum="624A85F1832B06BC" modified="2014-10-01" version="1">MDVSIVSDGRGVTVWNEKKQNYDVDGYSLAITSALRAIGWDVDILVHQPRIIVYQGICLFNPPRPLPDWDSLGSQSATCVCLPLWAICVLTAFLFVVHGAECTFLLSNLTPDTSSATPDRDIHPASFQCAGCFRQCTPRLIWHFRTSTRERLVGLMCEECGMCCKSKAGLVAHHRDHVHESVGRNVVTHLACADCSHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRH5</accession>
    <name>A0A074ZRH5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166585.1">
        <property type="nucleotide sequence ID" value="XM_009168321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRH5"/>
    <dbReference type="STRING" id="6198.A0A074ZRH5"/>
    <dbReference type="GeneID" id="20317955"/>
    <dbReference type="KEGG" id="ovi:T265_03768"/>
    <dbReference type="CTD" id="20317955"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="44886" checksum="D61E5DB157F9F1E6" modified="2014-10-01" version="1">MADRLTELQDAINLQAENLCNAIGVIQQVAQPSFFSDFNWSSRASKPEYQAFLQGQPPDDIGRNFAVVIAATARQLDALIGSLPEEEASSEIQRAAFQRLVEDYRTEGWKLTRVTERLESRLTEVRLFLTAIAQTQLTTQSLETEKKTKSPEGAISAPVLRSIANSMETKQPPSVPEEVDFSDWNPPATEGQWFPHLALTLTVIVFFRLIRAFGVVNWCHKWLVFLSNIATTAGRARRTERFKLAAELTELRATLKTIKMGEQFAQYSRCERRIKALERQLSQTRPETLSGSFIRAMVINVLLYVLEGILIVWLIARAPSKTISERSLEDAELRDSYFLPFLYGLQYVPSKILSLVWICLCHSVARPVATQLQSLISQSTWSVTLDNGALGEQYPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRK4</accession>
    <name>A0A074ZRK4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13244" checksum="60014FC06D65F844" modified="2014-10-01" version="1">MRDISFSVKGRVYNAAARSALLYGRCAPRTSKDFQCLTIDAFGALPESGGNAGSVILSEGLLSLIWCPHRDWDDDHVSTNFQGLDCSYLPLDFEEDVEAAEVDTVRGYFLALNAFFRGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Opisthorchis viverrini</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="PDZ_6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
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            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <begin position="1059"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <begin position="1683"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <begin position="1826"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1924"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
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            <end position="2119"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="2235"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1638"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1820"/>
        </location>
    </feature>
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        <location>
            <begin position="2329"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1175"/>
            <end position="1208"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2330"/>
            <end position="2341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2423" mass="262686" checksum="5B34B0121E9D9671" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSY9</accession>
    <name>A0A074ZSY9_OPIVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSY9"/>
    <dbReference type="STRING" id="6198.A0A074ZSY9"/>
    <dbReference type="GeneID" id="20320469"/>
    <dbReference type="KEGG" id="ovi:T265_06287"/>
    <dbReference type="CTD" id="20320469"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="261"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="613" mass="68643" checksum="B06BE955DE4BFBF8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT52</accession>
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        <recommendedName>
            <fullName evidence="12">Signal peptide peptidase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">T265_04303</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009169002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT52"/>
    <dbReference type="STRING" id="6198.A0A074ZT52"/>
    <dbReference type="MEROPS" id="A22.003"/>
    <dbReference type="GeneID" id="20318485"/>
    <dbReference type="KEGG" id="ovi:T265_04303"/>
    <dbReference type="CTD" id="20318485"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63086" checksum="C903DECE7D33198B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT69</accession>
    <name>A0A074ZT69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601092">
        <property type="protein sequence ID" value="KER18459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177794.1">
        <property type="nucleotide sequence ID" value="XM_009179530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT69"/>
    <dbReference type="GeneID" id="20326437"/>
    <dbReference type="KEGG" id="ovi:T265_12269"/>
    <dbReference type="CTD" id="20326437"/>
    <dbReference type="OrthoDB" id="6308463at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="288" mass="30810" checksum="94D5254657F5B81A" modified="2014-10-01" version="1">MRLIEFHSTECEDWQPSNTESHQPSTEVRVTTTTTATTTAHHKSIPAGTSQTIRNTNLAKQTPEDDEEQHSTDHTQQTDSYPNNKTSSERVASIRNLSDEIVGPTTEVDNSIQTTTSQTVRWSTGRSDVIPSSEDGRPSSSLVVSAPATPNKLGYSITTTATTAMGSSAQTSLRQTASETVLRNSVHAGQSDTPKTDISSNTTVSFSTRNTEALGKGESALHSQNATRTGTGHKTQTTVGVNALSDAKSDVRQQETRPSDTISSVETSTQQTSVTQQTLHSALTTTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTG3</accession>
    <name>A0A074ZTG3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165491.1">
        <property type="nucleotide sequence ID" value="XM_009167227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTG3"/>
    <dbReference type="STRING" id="6198.A0A074ZTG3"/>
    <dbReference type="GeneID" id="20317062"/>
    <dbReference type="KEGG" id="ovi:T265_02874"/>
    <dbReference type="CTD" id="20317062"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="330"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="495" mass="54503" checksum="89D3165E4F25301C" modified="2014-10-01" version="1">MHQLTCLRHGFRLSFVREIRRALHLSASRNYYISGPQEPFSPVPGRFPKWASSGDEAFYFLKDGANVFLHGGAATPSLLLKELYEYVMSNNLKDIKLFHIHTEGHYPFNDIAAQNRFRSTSLFTGGNCREAIREGRADYTPIFLSEIPLLFRRKHLQLDLAVINVTPPDKHGFCSLGPSVDVTRSAIQNAKHIVGNFCLIHSTVFFLTKAQVNDQLPLTRGDASIHFSNLTVLRTGAQPCHQMSPRVASDVEDRIGTIIAENLVEDGATLQTGIGAIPDSVLSKLTNHRHLGVHTEMFSDGVVDLVNVGAITNAYKKVRPGKLVSSFVVGTNKVFEFLDDNPMVDMCDVGWVNSPVVIARNPRPVAINSCIEVDLSGQVSSDSIGQTIYSGFGGQVDFLRGAALSADGQGKPIIALPSTTKRGETKIVPHLKLGGGVVTTRAHCHYVVTEFGIAYLFGRNIRQRAYALIQIAHPDHRESLEKSAYEIYNVMPSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTH3</accession>
    <name>A0A074ZTH3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165507.1">
        <property type="nucleotide sequence ID" value="XM_009167243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTH3"/>
    <dbReference type="STRING" id="6198.A0A074ZTH3"/>
    <dbReference type="GeneID" id="20317078"/>
    <dbReference type="KEGG" id="ovi:T265_02890"/>
    <dbReference type="CTD" id="20317078"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="242" mass="27395" checksum="3B43E373245C3019" modified="2014-10-01" version="1">MEGRVEVAFGDTQLKVTPVPMDYLTQFSIIDTNRDGLITRRELFKYALSIGEDISMVDTWFKLFDAQDKGVITIDDVSRTLGVPPPKYYKERLSRRSVGDGFDVFKSTPDLSRTTSVERADIYKSATRSLPKSKSQEISGTYHMTLHDLKGIDIEPVEELLRTKLTHVIYSILDAGINEKMQDSLLAAEIGRALDRQYGRNWQVFVSKKTLGCAFGHLPGKMVQLKHKSYFVVTYQTGVNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTM9</accession>
    <name>A0A074ZTM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165757.1">
        <property type="nucleotide sequence ID" value="XM_009167493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTM9"/>
    <dbReference type="GeneID" id="20317275"/>
    <dbReference type="KEGG" id="ovi:T265_03088"/>
    <dbReference type="CTD" id="20317275"/>
    <dbReference type="OrthoDB" id="6242940at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="409" mass="46260" checksum="D7150642023F35D8" modified="2014-10-01" version="1">MFSNQYMGTRFASRSLPRPASSTTSWQQGPYSRLDSYNEIPKPVNARPMPDENEEVDYSFMNLPVRERRKLFLGGGRPSRFNSVGQQSMTMPRMRMPSHPPPSRYETQSEYGADVDGFRWESNITPSWVSGTRSAPSFGTTKKSSTTGTIILQTHRGTTPRATTPVQRPSEVCIRQHSQYATGPFSPSSPERQQSSPGRFYTVRPPQVTVSPTRQPQYSTTIRVHDPYTMSPQGKVVSNGTTRVYPGRRYPSTMGRQVYGFNSSDTQQGHPIIVPGRMVQPLRVNVFSSDSSTVHYSPTSKVDNSWSNATPVYPAYPANLERSYHVDTHVQPDRYRRGLSVQPVAIYSRPSSPVYRRTESQQIWRPLQAPNWVPTEQAKRHGRYISSPKSPSVRQKAPEPQDQYGVSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU47</accession>
    <name>A0A074ZU47_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596680">
        <property type="protein sequence ID" value="KER29357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166897.1">
        <property type="nucleotide sequence ID" value="XM_009168633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU47"/>
    <dbReference type="STRING" id="6198.A0A074ZU47"/>
    <dbReference type="GeneID" id="20318201"/>
    <dbReference type="KEGG" id="ovi:T265_04015"/>
    <dbReference type="CTD" id="20318201"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55705" checksum="10A3062E1BB07454" modified="2014-10-01" version="1">MRSYPLSDQTEHTFASKAWLYVPLSRFPVIKTVAAGTNVPMARALLVLAGANGLVTRVMEALAIHTDSSFSISQINRSAVAPFRCLAAIPHEGGTRAGLMPGCPGLDSGIREVEVRFKTRTFRAAHHLQYTDECRACVHLSACNVSRTMNGSDNSAKCIHDQLAQQGSFLTCGEIEGILHSLKGISLKLIVTNVPREVYTDNLAQETFEGLFKPLDPHCTFLYLPSFNRAQVYMTNPEAALLARLQIQGWKLPDSVLSQISPESRLSSNHEGINCFIDHVEQYDSEDDTDSGSDVEMCTCGSLTKQPFASGPLGSVEDLYQISSSVEEPLSPSEVACDIPIWNKGQPPPVTVETATSLDSIGDQQSRRVSERKPSTPDAENTSEASGDDVTGSLVPLVSRPTAPCTYCKKRNARSKKSKMQHLAPPKPPRLFLLSPPCSPPVGWEPKPECEPVINYELLEALAALSPGEAFELHPSDQEHKHPSIVITPCESSSDGPRPQIIHTRCPERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUC6</accession>
    <name>A0A074ZUC6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165557.1">
        <property type="nucleotide sequence ID" value="XM_009167293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUC6"/>
    <dbReference type="STRING" id="6198.A0A074ZUC6"/>
    <dbReference type="GeneID" id="20317117"/>
    <dbReference type="KEGG" id="ovi:T265_02929"/>
    <dbReference type="CTD" id="20317117"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:dihydrofolate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23414" checksum="50E0DF51F32D57B2" modified="2014-10-01" version="1">MSIVGVPDCLSQGSCVSPNFYLPYLNETAEHYCCCFEQLGNRTSWKSTLETEDMAFFKKLTTEAKPGLKNVVIMGRNTWNSIPEKFRPLQDRINIVISSTLASAPPGVFVLPNLTACMDLLEQQLSCDADRIFVIGGSQLYKDVLEQKKYPVRIFCTHVMKDVDCDTFFPEVNWDELKKIELPEVPSEVIEENGYTYKFAVYDIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV14</accession>
    <name>A0A074ZV14_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heparan-sulfate 6-O-sulfotransferase</fullName>
            <ecNumber evidence="8">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucosaminyl-[heparan sulfate](n) + 3'-phosphoadenylyl sulfate = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56604"/>
            <dbReference type="Rhea" id="RHEA-COMP:9830"/>
            <dbReference type="Rhea" id="RHEA-COMP:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:58388"/>
            <dbReference type="ChEBI" id="CHEBI:140604"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sulfotransferase 6 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="8"/>
    <dbReference type="EMBL" id="KL596674">
        <property type="protein sequence ID" value="KER29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166578.1">
        <property type="nucleotide sequence ID" value="XM_009168314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV14"/>
    <dbReference type="STRING" id="6198.A0A074ZV14"/>
    <dbReference type="GeneID" id="20317948"/>
    <dbReference type="KEGG" id="ovi:T265_03761"/>
    <dbReference type="CTD" id="20317948"/>
    <dbReference type="OrthoDB" id="406981at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017095">
        <property type="term" value="F:heparan sulfate 6-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010635">
        <property type="entry name" value="Heparan_SO4-6-sulfoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812">
        <property type="entry name" value="HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12812:SF0">
        <property type="entry name" value="HEPARAN-SULFATE 6-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="594" mass="69161" checksum="2343DA30B761878A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV92</accession>
    <name>A0A074ZV92_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166483.1">
        <property type="nucleotide sequence ID" value="XM_009168219.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZV92"/>
    <dbReference type="GeneID" id="20317864"/>
    <dbReference type="KEGG" id="ovi:T265_03677"/>
    <dbReference type="CTD" id="20317864"/>
    <dbReference type="OrthoDB" id="10653503at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="2972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3009"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="586"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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    </feature>
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    </feature>
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        <location>
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    <sequence length="3189" mass="344092" checksum="4BC529A3FDC2FCD3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW18</accession>
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            <fullName evidence="14">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
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        <name evidence="15" type="ORF">T265_02153</name>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="34341" checksum="7CBC765AF0F9359F" modified="2014-10-01" version="1">MRRKSYNTIRLVCSGLRCHIRCDLRACGSLREVLKKASTQKVVPDKYAYSPLFSFVVDDLMRRTVEGLQNLGIHIAADENLVHLEYANEMILVFEERKTQVLLDELTTLVGQKHSGFFGLAEKIISAAVPAVWFDRDEVLDRQRTAARLKEHVMSPNAEPLLIFPEGTCINNTSVMKFKKGCFEVGAPIHPVAIKYNPLFADCFWNSSRDSLLQYTFKIMSSWAMVVDVWYLPPTRMRDDEDGIMFAGRVQQSIANCGGLLNMNWDGELKRQRPKDTLKLAQQLFISRYLVPQEEDKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWQ2</accession>
    <name>A0A074ZWQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165863.1">
        <property type="nucleotide sequence ID" value="XM_009167599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWQ2"/>
    <dbReference type="GeneID" id="20317367"/>
    <dbReference type="KEGG" id="ovi:T265_03180"/>
    <dbReference type="CTD" id="20317367"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11774" checksum="DD7525C512B2A6E9" modified="2014-10-01" version="1">MKQSLRKCARNAACYIKLDELRAVGAARERREFTVTRQHSTLNFHNFPGGTQTTKTEDGPQNYMTATSEQPETTFRVKTTHILVKIELKSRLKFPSIMQLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZH6</accession>
    <name>A0A074ZZH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164810.1">
        <property type="nucleotide sequence ID" value="XM_009166546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZH6"/>
    <dbReference type="GeneID" id="20316520"/>
    <dbReference type="KEGG" id="ovi:T265_02332"/>
    <dbReference type="CTD" id="20316520"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="440" mass="50846" checksum="CD900CB345500903" modified="2014-10-01" version="1">MGGATSKDNGDLLTILENDEAECLVPFVALPSERYESDERIFKEDTMLDRRKKRNLLHIASILSATKCVKLLVNSPYFWDPDRLDAKGWTPLQIAEDRDDLSTLYELAVHSRELRHFKPTIPTDGGRQFVSSCLVWPQDVLLDPFDMIEFYLPTLRGIGRGVTPYLTVRTSKTGLSGRSMALLFELLLANPYMSTVTALVGNVDQDPFSNNADCEASCLWPMQPIEVSYISDHDDQCQIYPDCLFRSWMLSFNYQDDFFQAFKELYNIWKFHRFAGSYSEENENIKARLSPITLLSACRVAIRRHLVNKTFPSIPDSQACIYPNYVRHVLQLGLPQILTDFLLYREMWPDTEWTEQPRWRDRKKRRPREVKLDAHGPGYVVDNGFIPNLRIPCNALPFKYTGIQKYSEGKREAELEKTIRGKAYWDVRLPNLLGKSMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1D9</accession>
    <name>A0A075A1D9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162782.1">
        <property type="nucleotide sequence ID" value="XM_009164518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1D9"/>
    <dbReference type="STRING" id="6198.A0A075A1D9"/>
    <dbReference type="GeneID" id="20326765"/>
    <dbReference type="KEGG" id="ovi:T265_12597"/>
    <dbReference type="CTD" id="20326765"/>
    <dbReference type="OrthoDB" id="1746725at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF9">
        <property type="entry name" value="UNCOORDINATED 115A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="1">
        <location>
            <begin position="429"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="494" mass="53356" checksum="AF1EB6ED02F950ED" modified="2014-10-01" version="1" fragment="single">ESLVQPRPRPDRSLSPDSAAEYWAEARRLASYPNARIPDSTSLPAIERFDFPAPPSPAVVMIEKRREKRLTGKRSNVGTLDSEQSRDGTMIGADLTDTELSALPPSVSLKLHQIDSEIETLKRLGESSGITGALIQELEASKLVYARAPELDPISASRSPNAGTEPSYKTRYERHVFSSPSRDTRRDHRAAHSLSYRMDYSCTGGRSGTIPIVASTPRPGYTSGALYGRAVSLPRPALAGVNGDLTNASGPSQSVLPGGSAFRSSTLAATKHDAPLHTERTGGKLVYAGAGLLGSGDHTLTTDESLHTTLAGFESQAGVTEAVGSLTASAISMDGLTVCSGDDGTTLAPSRSAYVIKSGTLTGLPPSVTGLRPVSAMLKQQQQQFLSSRPRSRTLTPVRHGFASDSDMTDIDSYPSVQSWLRPSSAQKKTSFKICPYEQLRVSAQRPLKGLDRTRLENYLSSTEFEALFGMPMHAFQRLPEWKRNDLKRKVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1H3</accession>
    <name>A0A075A1H3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596982">
        <property type="protein sequence ID" value="KER21234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175022.1">
        <property type="nucleotide sequence ID" value="XM_009176758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1H3"/>
    <dbReference type="STRING" id="6198.A0A075A1H3"/>
    <dbReference type="GeneID" id="20324562"/>
    <dbReference type="KEGG" id="ovi:T265_10394"/>
    <dbReference type="CTD" id="20324562"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="315" mass="35565" checksum="71959300917B1E96" modified="2014-10-01" version="1">MKRLPRMSYVRGSAPGASTGYALLMSYSKSETRVQYIPPRCGLTGIIAPEREDDHSNKSGEVFDYLVTNGRMKEKEARVKFRQLVSAVEYCHSKKIVHRDLKVRWGPRDPHCAWLETLPTDVSGVLVVRLYPDRLSECLLSNKSWLYGSEASVLNTDVMLSMMMMTSQWLNMPIAENLLLDKDYNIKLADFGFSNFYDGENKLDTYCGSPPYAAPELFQGQKYFGPEVDVWSLGVILYTLVSGSLPFDAQHLKTHLVSVSSAFRLVSSGLSIKLFSHADHRAAPSFRDYMRIPRSKIWRQCGMNVSGQGMIVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U4</accession>
    <name>A0A075A2U4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166395.1">
        <property type="nucleotide sequence ID" value="XM_009168131.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20327457"/>
    <dbReference type="KEGG" id="ovi:T265_13290"/>
    <dbReference type="CTD" id="20327457"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="605"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER29905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1348" mass="154750" checksum="A952F9BD556DB612" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A460</accession>
    <name>A0A075A460_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Papain family cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165892.1">
        <property type="nucleotide sequence ID" value="XM_009167628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A460"/>
    <dbReference type="STRING" id="6198.A0A075A460"/>
    <dbReference type="GeneID" id="20317396"/>
    <dbReference type="KEGG" id="ovi:T265_03209"/>
    <dbReference type="CTD" id="20317396"/>
    <dbReference type="OrthoDB" id="6064724at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="252"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="486"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER30375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="79664" checksum="D31CA24A1E32F1FC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A492</accession>
    <name>A0A075A492_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596912">
        <property type="protein sequence ID" value="KER22199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174056.1">
        <property type="nucleotide sequence ID" value="XM_009175792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A492"/>
    <dbReference type="GeneID" id="20323820"/>
    <dbReference type="KEGG" id="ovi:T265_09652"/>
    <dbReference type="CTD" id="20323820"/>
    <dbReference type="OrthoDB" id="10498389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="11614" checksum="28B329B01BE44A2A" modified="2014-10-01" version="1">MITHSVPSIFHSLSSNTLSVPSCHATQRLHEGLDTARLPKPRQRKPSGTGRVQTMGLPVAENPSTAHDQFRPLWGSSGSCSPRISVNLMLYLEPNCTKLANIHSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4K3</accession>
    <name>A0A075A4K3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165792.1">
        <property type="nucleotide sequence ID" value="XM_009167528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4K3"/>
    <dbReference type="STRING" id="6198.A0A075A4K3"/>
    <dbReference type="GeneID" id="20317310"/>
    <dbReference type="KEGG" id="ovi:T265_03123"/>
    <dbReference type="CTD" id="20317310"/>
    <dbReference type="OrthoDB" id="272681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37950" checksum="EAF5897F4767D5F9" modified="2014-10-01" version="1">MENEDVVKDMGFRKGEKTEKLNPSCLFPGLSASGHRSSEKSKLLVIGVGLMRTGTTSLKKALEMLYDRPCYHMSDVFGCHKEAHIKAWLWAFDQTAITAGHIPREFWDAVYGNCCAAIDYPTCAFYKQLMDVYPEAKPKWLEREFTDRKVRGSNPTSASRLPLSRLGQPGSIPALLILTARAPTDWLKSCRATMLSADMLKKPTFGDRLTYWRRGILHLPELHHTMFARTLGSEYRTMTDGELITSYSNWINEVERSVDRNRLLIFQPEAGWGPLCKFLNLPQPDITYPHLNKRDLMVGVLTELINEGKLIEKIILCLAATLVCAISGALLRVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5G5</accession>
    <name>A0A075A5G5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162745.1">
        <property type="nucleotide sequence ID" value="XM_009164481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5G5"/>
    <dbReference type="STRING" id="6198.A0A075A5G5"/>
    <dbReference type="GeneID" id="20314841"/>
    <dbReference type="KEGG" id="ovi:T265_00653"/>
    <dbReference type="CTD" id="20314841"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="69613" checksum="C302F3819DE75509" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5X1</accession>
    <name>A0A075A5X1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KL596877">
        <property type="protein sequence ID" value="KER22839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173421.1">
        <property type="nucleotide sequence ID" value="XM_009175157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5X1"/>
    <dbReference type="STRING" id="6198.A0A075A5X1"/>
    <dbReference type="GeneID" id="20328939"/>
    <dbReference type="KEGG" id="ovi:T265_14773"/>
    <dbReference type="CTD" id="20328939"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="386" mass="43850" checksum="23CAF3F5C91FC14F" modified="2014-10-01" version="1">MDDCQLPCSTDFIIGGKWRLVRKIGSGAFGAIFLGVNIKTSEEVAVKLERVNARHPQLYFESRVYKVLQVTELPSCMKNDFFQGTSGIPHIYYYGLDGVRDMYHALIMDLLGPSLEDLFSFCGRRFTMKTVLMLADQMLWRLDFLHTKNFIHRDIKPDNFLMGIGRNCNKVFLCDFGLAKKFRDSRSHRHIAYREDKALIGTARYASINSHAGIEQSRRDDLESLGYVLMYFLRGTLPWQGLKAATKAQKYEQIYEKKVSVPTDVLCRGYPAEFSIYMNHCRSLRFEETPNYGFLRSNFRNLFRTLSFVWDYVFDWTLLRQKGSTVHQQCQGASLLNRDPPAGATAGASAGATAGANVFVPVGDNPTELKNLAGRLPTDPIQPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Z3</accession>
    <name>A0A075A5Z3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162442.1">
        <property type="nucleotide sequence ID" value="XM_009164178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5Z3"/>
    <dbReference type="GeneID" id="20314593"/>
    <dbReference type="KEGG" id="ovi:T265_00405"/>
    <dbReference type="CTD" id="20314593"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13494" checksum="A32BDE02896B3F32" modified="2014-10-01" version="1">MESILIVASLLSSRCPFSCWTSSIEARARWDVEVNKAVTYHQVTYAGYKWPDLCPAFPVTPVHVVKHRPGATSFKTTTRQRTRGGLSSEQSTKLCARMRLSLFKRMRAPHGPPETAASTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6A7</accession>
    <name>A0A075A6A7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173292.1">
        <property type="nucleotide sequence ID" value="XM_009175028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6A7"/>
    <dbReference type="GeneID" id="20323238"/>
    <dbReference type="KEGG" id="ovi:T265_09059"/>
    <dbReference type="CTD" id="20323238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7092" checksum="0971DFEEB1EBDE40" modified="2014-10-01" version="1">MAFANMPVLVICGAQERLRSRPLKLHPPVAFPRIYINARDLHVAEHSSECKSPASVPFCIYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6L9</accession>
    <name>A0A075A6L9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173150.1">
        <property type="nucleotide sequence ID" value="XM_009174886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6L9"/>
    <dbReference type="GeneID" id="20323122"/>
    <dbReference type="KEGG" id="ovi:T265_08943"/>
    <dbReference type="CTD" id="20323122"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="11914" checksum="2310F14ACD22EF3B" modified="2014-10-01" version="1">MVSATLQNVTVPTLSHTPKSVVCPSSTVANTETQANMQSETALGGHVQGRTTWTRVEWSDLDWWSMDSGLKSILTVHFRLQAKATPAYIHLEPVIGTHKEHPEVEPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A737</accession>
    <name>A0A075A737_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596858">
        <property type="protein sequence ID" value="KER23244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172992.1">
        <property type="nucleotide sequence ID" value="XM_009174728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A737"/>
    <dbReference type="STRING" id="6198.A0A075A737"/>
    <dbReference type="GeneID" id="20322995"/>
    <dbReference type="KEGG" id="ovi:T265_08816"/>
    <dbReference type="CTD" id="20322995"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="626" mass="70184" checksum="72B3A746130F5501" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A772</accession>
    <name>A0A075A772_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161981.1">
        <property type="nucleotide sequence ID" value="XM_009163717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A772"/>
    <dbReference type="GeneID" id="20314248"/>
    <dbReference type="KEGG" id="ovi:T265_00060"/>
    <dbReference type="CTD" id="20314248"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11315" checksum="07E1580E202027A3" modified="2014-10-01" version="1">MVVRLHVHTVSHLDANVKPFISFSTDIHTISLSTGEFVTKCQLHYRFVTRSPSIGELITLHRLRWLGHVLRMPGDRLPRRVFSHNHVKGRNEPEAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A937</accession>
    <name>A0A075A937_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163992.1">
        <property type="nucleotide sequence ID" value="XM_009165728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A937"/>
    <dbReference type="GeneID" id="20315850"/>
    <dbReference type="KEGG" id="ovi:T265_01662"/>
    <dbReference type="CTD" id="20315850"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8578" checksum="243E71F35D155523" modified="2014-10-01" version="1">MQLPKQRTPAATTCGKSTVLKEQQAREYPMKLLDIRDSAGGLHDWFHSGEAKSSTLHTPGNMLQLLHYDCEIPTALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAY5</accession>
    <name>A0A075AAY5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163274.1">
        <property type="nucleotide sequence ID" value="XM_009165010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAY5"/>
    <dbReference type="GeneID" id="20315255"/>
    <dbReference type="KEGG" id="ovi:T265_01067"/>
    <dbReference type="CTD" id="20315255"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="12580" checksum="A0B06D928937E830" modified="2014-10-01" version="1">MKKRNGATILNKGESVLVVSFYRDWLNEFRRHLEDDGASVGELEIWKMCLVILMVCIILVYYIFINCAPPHIKRRHLIRPLADRYSLTSTSFFQEERKKYAREQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB80</accession>
    <name>A0A075AB80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163152.1">
        <property type="nucleotide sequence ID" value="XM_009164888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB80"/>
    <dbReference type="STRING" id="6198.A0A075AB80"/>
    <dbReference type="GeneID" id="20315161"/>
    <dbReference type="KEGG" id="ovi:T265_00973"/>
    <dbReference type="CTD" id="20315161"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705647" description="IMD domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="IMD" evidence="4">
        <location>
            <begin position="104"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="981" mass="105472" checksum="E8EEA68E6F22BE4D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABF5</accession>
    <name>A0A075ABF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter, ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_07485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171282.1">
        <property type="nucleotide sequence ID" value="XM_009173018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABF5"/>
    <dbReference type="STRING" id="6198.A0A075ABF5"/>
    <dbReference type="GeneID" id="20321664"/>
    <dbReference type="KEGG" id="ovi:T265_07485"/>
    <dbReference type="CTD" id="20321664"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="300"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="629"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="948"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="130449" checksum="28AD67C71EC9FFAF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABH1</accession>
    <name>A0A075ABH1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-galactosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER24999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171262.1">
        <property type="nucleotide sequence ID" value="XM_009172998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABH1"/>
    <dbReference type="STRING" id="6198.A0A075ABH1"/>
    <dbReference type="GeneID" id="20328465"/>
    <dbReference type="KEGG" id="ovi:T265_14299"/>
    <dbReference type="CTD" id="20328465"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035373">
        <property type="entry name" value="Melibiase/NAGA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17450">
        <property type="entry name" value="Melibiase_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha galactosidase A C-terminal" evidence="7">
        <location>
            <begin position="347"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="468" mass="52901" checksum="9A355F9E69DCF054" modified="2014-10-01" version="1" fragment="single">PSEVVRSKSRSHCVSSLSVRVSPSNFLHCVAHAMRPLVILCTVLLNGVFALENGLARTPPMGWMSWERFRCQTDCVQYPEDCISEKLIRRTVDRMISDGWKDVGYEYVITDDCWPEKERDRNTQEIVADQTRFPSGIEGLGEYIHGHGLKFGIYLDYGTMTCAGYPGSMDFLEIDTKSLAKWKVDYVKVDGCYSPLDEMPEGYEKFGELLNQTGRPIVYSCSYPAYIPWRSNPKMLDWQRLKTNCNLWRMFGDIDDSWDSVLTIINLMRDTQSTLQPIAGPGHWNDPDMLVIGDFGLSLDQERVQMGMWCLFAAPLLISADMDHMNPESAAILKNPHLISINQDSGGHQAKYITTKNGVQLWTRLLADQPNTWAIAFMNPISGGGPKAISVSLKEMQLESPPPEPVFFDLIDVFDGEVFTSVQLNEKFTVRVNPTGIVMFKVEVHKPAYIAHILLHYLGLRNVSVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABP4</accession>
    <name>A0A075ABP4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171183.1">
        <property type="nucleotide sequence ID" value="XM_009172919.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075ABP4"/>
    <dbReference type="GeneID" id="20321588"/>
    <dbReference type="KEGG" id="ovi:T265_07409"/>
    <dbReference type="CTD" id="20321588"/>
    <dbReference type="OrthoDB" id="6242809at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF10">
        <property type="entry name" value="BLISTERY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
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        <location>
            <begin position="989"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1320" mass="147292" checksum="2BD9D8E845A27A39" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC74</accession>
    <name>A0A075AC74_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC74"/>
    <dbReference type="GeneID" id="20314783"/>
    <dbReference type="KEGG" id="ovi:T265_00595"/>
    <dbReference type="CTD" id="20314783"/>
    <dbReference type="OrthoDB" id="6270619at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15308" checksum="B4A2671B8A9B92E7" modified="2014-10-01" version="1">MCTQMNLVMREDSWRARQLVRKIGVAEHERFTNYILPRKPSDLTFDETVAVLSSIFGEQASLFSRRVHCMNLSKNASEDWVTYAGKVNKDMTEDEFKCLIFVCGLTSPEDTDIRARILSKVEQNSDVKLQNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACB9</accession>
    <name>A0A075ACB9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
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        <property type="protein sequence ID" value="KER25369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170884.1">
        <property type="nucleotide sequence ID" value="XM_009172620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACB9"/>
    <dbReference type="STRING" id="6198.A0A075ACB9"/>
    <dbReference type="GeneID" id="20321348"/>
    <dbReference type="KEGG" id="ovi:T265_07169"/>
    <dbReference type="CTD" id="20321348"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="20974" checksum="FAA6C49DDE3F8D07" modified="2014-10-01" version="1">MVCEKCEKKLGKVITPDPWKAGARNTVSSGGRKLNENKLLTASKNRFNPYTKNFRRCRVCAQTVHQPGSYYCQSCAFKKGICAMCGVRLVNTTNYCQSLVYYLVPQAIEQWNEWALIRTGRDELDCRRTIKVRWRKWLGREFTDRKVLGSNPTSAWLGQPGSIPALGQPSGGMAVRHGKCATAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACI4</accession>
    <name>A0A075ACI4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596776">
        <property type="protein sequence ID" value="KER25459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170785.1">
        <property type="nucleotide sequence ID" value="XM_009172521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACI4"/>
    <dbReference type="GeneID" id="20321262"/>
    <dbReference type="KEGG" id="ovi:T265_07083"/>
    <dbReference type="CTD" id="20321262"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704600" evidence="1">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="25072" checksum="FEEE51C0A2638010" modified="2014-10-01" version="1">MYEGPFKWTGAVVTFALALARTHAPALVCSEYSHCVPFCELSSPTLSTGAGQQQITHIDESADITRYNQITSACLKLISNFLVPGCVMVGKRARFLMLLLECTLVLYRLGDSTMLDGPNVDQVDSTDDFLTDATLRGHHTHHILFLCQNYTLLWGEMAQWLESELINRKVCGSDLTSASRLLLSRLGQPDSILALLLPSDCIAARHRKGATAERFFYTLLSILSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI38</accession>
    <name>A0A075AI38_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165349.1">
        <property type="nucleotide sequence ID" value="XM_009167085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI38"/>
    <dbReference type="STRING" id="6198.A0A075AI38"/>
    <dbReference type="GeneID" id="20316958"/>
    <dbReference type="KEGG" id="ovi:T265_02770"/>
    <dbReference type="CTD" id="20316958"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="496" mass="54874" checksum="4C3267D2869A65BE" modified="2014-10-01" version="1">MELGDELNSGITPVKAQHPMARFTLISIDLDLGRIQQTDSNTQHQTGPDFCRNVNFLLRRLILLISFFDGSLSTYPSLELCICCLCCCSELADVDVSPFLVFLSGTILSSGMIGDVAQASIASTDSISMVSGIAGIERSSDFVTRLSRATLMTFILASNGGILSFQDDQQHHQGFLVASLVYVQRYDEPVLHECLEDLRLLNVFFSSETNDRVEKSTNHRGGILLTCQTMHHDIVSTSLAHVCLLRPVKLVGVALVQDAAFFEDLSWKHEGPDDVKRSSSSRADIMCSGLDMAFTSRTFVRPHTGSQQTVSFIGNGRWRLYPNRLEFRQTLAAFEQLRQLPESSNQQEEEAIKGVLRSWLHIFDDGAKSPLSVVIVDNIEGLIEYNPVGPRFSNFIVQAIRDLVSQPLKARQFDTAAFLSPGVNETRRCGRRNSRVPTKIIGGVSPMESGWHTKAQSETRPKLTGLMSFSSAYRKSARFTTSRSKASGSSCVFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI51</accession>
    <name>A0A075AI51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165263.1">
        <property type="nucleotide sequence ID" value="XM_009166999.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AI51"/>
    <dbReference type="GeneID" id="20316885"/>
    <dbReference type="KEGG" id="ovi:T265_02697"/>
    <dbReference type="CTD" id="20316885"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04013">
        <property type="entry name" value="C2_SynGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="885"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1241"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1412"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1584"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1811"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1673"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1760"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1486"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1586"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1819"/>
            <end position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1873" mass="207042" checksum="FB0AE8A0B2FFE92C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI84</accession>
    <name>A0A075AI84_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165041.1">
        <property type="nucleotide sequence ID" value="XM_009166777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI84"/>
    <dbReference type="GeneID" id="20316702"/>
    <dbReference type="KEGG" id="ovi:T265_02514"/>
    <dbReference type="CTD" id="20316702"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="9759" checksum="B20A40BB734D6DF7" modified="2014-10-01" version="1">MCELSCLLTKPSACHCKQVQSHFNPYTGIADKIASSLHNAGSFACDTALPGSPNYWISDRTVSLLKSRRNIPVLTNYQKSSESERASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIM5</accession>
    <name>A0A075AIM5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164380.1">
        <property type="nucleotide sequence ID" value="XM_009166116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIM5"/>
    <dbReference type="STRING" id="6198.A0A075AIM5"/>
    <dbReference type="GeneID" id="20316166"/>
    <dbReference type="KEGG" id="ovi:T265_01978"/>
    <dbReference type="CTD" id="20316166"/>
    <dbReference type="OrthoDB" id="6247999at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32989" checksum="6D1C515C3D4F0CAA" modified="2014-10-01" version="1">MLVFHDCIPRKSLKRQIVKSLRKDRELWWTSKAREMENAFATGNSRVLYQLIRSTGPRKATVSETINEKDGSSIHWQKRRLERWAEHSEEQFSWPPAIQPVEIVHTGKWNVNLDHPSEGEIRYEVAALKREKAPGPDGLYPALFKEGRNSLVTHLTKLIGTMWDEEQVPSEWGMSTVIPIFKKGTRTLCENHRDISLDEEVECEDILMYLSISPEVDNPDDLSGGEDQGELLSSGAGVKKRADSPSGRSSEPPNKQMKRKEQCNAPVAPTININLPGSHTDELLVRRHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIP0</accession>
    <name>A0A075AIP0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_01901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164291.1">
        <property type="nucleotide sequence ID" value="XM_009166027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIP0"/>
    <dbReference type="STRING" id="6198.A0A075AIP0"/>
    <dbReference type="GeneID" id="20316089"/>
    <dbReference type="KEGG" id="ovi:T265_01901"/>
    <dbReference type="CTD" id="20316089"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="349" mass="40734" checksum="A204CC1C69511051" modified="2014-10-01" version="1">MVKKTKRQSLNFPDVQGWVPYTAFSKNRDSSEPTYAEVPKDWKEPEFKPEDNPHGRLFALSSFITLFPKYREKYIKEIWPALKKVLLEHHIRAELDLTESSMEVRTTPKTFDPFIILKARDVMRLLARSVPFEQAIRVLQDDIFSDVIEINLTNRERFIKRRNRLIGYEGETLKALELSTNCYIVVQGKTVSAIGHYEDLKQVRKIVLGCIYDNIHPAYSIKRLLIIKKLQADPTKKDVSWDRFLPKLKKKVLSRRRKPHKVRKKKEYTPFPPPITPSKVDIELEKGTYFLAEAERKRLKTATKIAQSEKVAKERKVKRAAAFVPPSSQEPKPKKKRKNANDDDNDAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIW2</accession>
    <name>A0A075AIW2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="6">2.7.7.102</ecNumber>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="6"/>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163880.1">
        <property type="nucleotide sequence ID" value="XM_009165616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIW2"/>
    <dbReference type="STRING" id="6198.A0A075AIW2"/>
    <dbReference type="GeneID" id="20315745"/>
    <dbReference type="KEGG" id="ovi:T265_01557"/>
    <dbReference type="CTD" id="20315745"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="560" mass="63353" checksum="67F615880D676CF8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJS9</accession>
    <name>A0A075AJS9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162360.1">
        <property type="nucleotide sequence ID" value="XM_009164096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJS9"/>
    <dbReference type="STRING" id="6198.A0A075AJS9"/>
    <dbReference type="GeneID" id="20314539"/>
    <dbReference type="KEGG" id="ovi:T265_00351"/>
    <dbReference type="CTD" id="20314539"/>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08358">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="316" mass="35778" checksum="533C777C0578671E" modified="2014-10-01" version="1">MNWLGYCLQHIMASRRALHFVFKIGDRKRSIDFLKDVLGMTVLRHEEFAEGCKAFCNGPYDGKWSKTMIGYGPEDNHFVLELTYNYGIGSYKMGNDFQYIQIDQPEAFSRLKSGSWPIISSSTECVETEMPGGYRFRIYNREPNGDPVKLVALSSSVLQRNPLRSAYFIDYWSRKCGMQLLSSTDTEATLCFDPAQCHLKLVAINQLVDHASAFGRIAFACPKKQVCLDLMELQSLMDAEKETILKRLVSLDTPGKATVEVIILADPDGHEICFVGDEAFRQLSQMDPNADKLLLDAIQLDKSDDWFRKHGGKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVY0</accession>
    <name>A0A074YVY0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597798">
        <property type="protein sequence ID" value="KER18833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177420.1">
        <property type="nucleotide sequence ID" value="XM_009179156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVY0"/>
    <dbReference type="STRING" id="6198.A0A074YVY0"/>
    <dbReference type="GeneID" id="20329964"/>
    <dbReference type="KEGG" id="ovi:T265_15799"/>
    <dbReference type="CTD" id="20329964"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15945" checksum="668B979439CA2D69" modified="2014-10-01" version="1" fragment="single">MISSNRPVKIVVLGDGMVGKTCLLMTYTSGHYPSEYVPTVFENYLGSVNVDGKELAFELWDTAGQEEYSHLRPLSYPNTDVIVLCFVSVRISSLENAEKKWCREISHSEHLRGKPIILVGTMSDLREEVTKVNASSVITYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXT2</accession>
    <name>A0A074YXT2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_16367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL621448">
        <property type="protein sequence ID" value="KER17997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178256.1">
        <property type="nucleotide sequence ID" value="XM_009179992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXT2"/>
    <dbReference type="STRING" id="6198.A0A074YXT2"/>
    <dbReference type="GeneID" id="20330532"/>
    <dbReference type="KEGG" id="ovi:T265_16367"/>
    <dbReference type="CTD" id="20330532"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER17997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9420" checksum="23B4D4845FE0D39A" modified="2014-10-01" version="1" fragment="single">MSGEPMATESEGETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYKSLTDPSVLDTGKELCIKLIPDKANSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYT0</accession>
    <name>A0A074YYT0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL602584">
        <property type="protein sequence ID" value="KER18352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177901.1">
        <property type="nucleotide sequence ID" value="XM_009179637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYT0"/>
    <dbReference type="GeneID" id="20330283"/>
    <dbReference type="KEGG" id="ovi:T265_16118"/>
    <dbReference type="CTD" id="20330283"/>
    <dbReference type="OrthoDB" id="10427132at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11569" checksum="28FB9E00BBCE5EF3" modified="2014-10-01" version="1" fragment="single">MIRQANVYYSISGPKTATVSFVPPEGILYVGTKDVITCVVADNSDAPGALTLEATPNDEKLFLLDKAKAQIKPPSGSETYHIAGNSTVKCTWTGTSEVPVVKSLDVQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ11</accession>
    <name>A0A074YZ11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597103">
        <property type="protein sequence ID" value="KER20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176227.1">
        <property type="nucleotide sequence ID" value="XM_009177963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ11"/>
    <dbReference type="STRING" id="6198.A0A074YZ11"/>
    <dbReference type="GeneID" id="20325500"/>
    <dbReference type="KEGG" id="ovi:T265_11332"/>
    <dbReference type="CTD" id="20325500"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="1">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="112" mass="12195" checksum="95C95B9C3EB5FCDA" modified="2014-10-01" version="1">MHSKRTGSTNVVVTSVDVFPCARDPCTLVKGTEVTIRIRFRGMARIIPGGARFEGSFDGEPATIPFPPNGVCTRLNPPCPIQPGQSYTYHYTAVVPEELRTVSQTKRCISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ13</accession>
    <name>A0A074YZ13_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597119">
        <property type="protein sequence ID" value="KER19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176342.1">
        <property type="nucleotide sequence ID" value="XM_009178078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ13"/>
    <dbReference type="GeneID" id="20329598"/>
    <dbReference type="KEGG" id="ovi:T265_15433"/>
    <dbReference type="CTD" id="20329598"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16429" checksum="FBE19626834B8852" modified="2014-10-01" version="1" fragment="single">MFGVELAVGALCLVFRDETETRINKALENVIMSFSDTSIPGNNGMTSSYRDLIQRVIQCCGIYGVDDYPGPNIPASCCIPGRAGCPSKSAAFTVGCKQVTNELVRQKFLTALALIMSVPLVKVFGLMCAILLCCVARRRDEIQYTEVHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZG2</accession>
    <name>A0A074YZG2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599271">
        <property type="protein sequence ID" value="KER18602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177651.1">
        <property type="nucleotide sequence ID" value="XM_009179387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZG2"/>
    <dbReference type="STRING" id="6198.A0A074YZG2"/>
    <dbReference type="GeneID" id="20330111"/>
    <dbReference type="KEGG" id="ovi:T265_15946"/>
    <dbReference type="CTD" id="20330111"/>
    <dbReference type="OrthoDB" id="6276287at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="14554" checksum="170D2E9740B9C5DF" modified="2014-10-01" version="1" fragment="single">QGGRNILEQLVVACGGEIITQIVPFLRSRPDAGDSPILGSDAQSSSRQSTTNVALVAPECCRTLKYFQALATLGRVPLLHTDWILDACREEAAAVADENMQPGVSLDWPMRLLLSCPGRYELARGISSIDGERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0T6</accession>
    <name>A0A074Z0T6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597041">
        <property type="protein sequence ID" value="KER20573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175671.1">
        <property type="nucleotide sequence ID" value="XM_009177407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0T6"/>
    <dbReference type="GeneID" id="20329455"/>
    <dbReference type="KEGG" id="ovi:T265_15290"/>
    <dbReference type="CTD" id="20329455"/>
    <dbReference type="OrthoDB" id="6254633at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="685" mass="76752" checksum="39F05AC8FA8501D3" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Y7</accession>
    <name>A0A074Z0Y7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein arginine N-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175637.1">
        <property type="nucleotide sequence ID" value="XM_009177373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Y7"/>
    <dbReference type="STRING" id="6198.A0A074Z0Y7"/>
    <dbReference type="GeneID" id="20325045"/>
    <dbReference type="KEGG" id="ovi:T265_10877"/>
    <dbReference type="CTD" id="20325045"/>
    <dbReference type="OrthoDB" id="412876at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000071">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="780" mass="86666" checksum="ED2196423F87CD3E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z158</accession>
    <name>A0A074Z158_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597032">
        <property type="protein sequence ID" value="KER20673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175576.1">
        <property type="nucleotide sequence ID" value="XM_009177312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z158"/>
    <dbReference type="STRING" id="6198.A0A074Z158"/>
    <dbReference type="GeneID" id="20329425"/>
    <dbReference type="KEGG" id="ovi:T265_15260"/>
    <dbReference type="CTD" id="20329425"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="376" mass="43156" checksum="F7FD245C99AB7388" modified="2014-10-01" version="1">MHAISEYTLICKLMWFLFERLTWNPAESLGCDVSRQMNALHQATSCFSHYDIRDIAILLIRLPKIRRQPMTGLALFGAHQAQSPGFRQPYALLETKLHEMSEYTLICKLMWFLFERLTWNPAESLGCDVSRQMNALHQATSCFSHYDIRDIAILLIRLPKIRRQPMTGLALFGAHQLTIGFALLGTHQIGATTEVPSTLCSTSTQIELISTNTLIYLSTGFSRKTQLNLTNFRNSRSRLATWCPPTTSRPQTQIDHIAISYRWRGSITDCRSFWNTFVDSDHALVRSRFALPQDRFRPSVSGSSDRRSPRASVNPMIYLNPNCTVFEKYTHLQINLVFTTDSTESLVYDILQLNVMHTGRLMIQLARYSRYPSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1C1</accession>
    <name>A0A074Z1C1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597015">
        <property type="protein sequence ID" value="KER20856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175401.1">
        <property type="nucleotide sequence ID" value="XM_009177137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1C1"/>
    <dbReference type="STRING" id="6198.A0A074Z1C1"/>
    <dbReference type="GeneID" id="20324850"/>
    <dbReference type="KEGG" id="ovi:T265_10682"/>
    <dbReference type="CTD" id="20324850"/>
    <dbReference type="OrthoDB" id="6269447at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098998">
        <property type="term" value="C:extrinsic component of postsynaptic early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905244">
        <property type="term" value="P:regulation of modification of synaptic structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099152">
        <property type="term" value="P:regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099158">
        <property type="term" value="P:regulation of recycling endosome localization within postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026204">
        <property type="entry name" value="GRIPAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978">
        <property type="entry name" value="GRIP-1 ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18978:SF1">
        <property type="entry name" value="GRIP1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="460" mass="51636" checksum="D1CE1F22F507A50F" modified="2014-10-01" version="1">MAQTALSAEEFQRFQSQLLDLREANIEANERRLRAEARVRQLESELLSAQKFADSHNHDRTRMEEMERENKHLREKIQGTEAAFQLQSSTLRAECHHLTAELTKLQQSLNKPRQTQGCQTISVPLTSVSAQTIDRLSDALDSEPLSLQEVAELRTALDISNASQAIYRLATQTLSDKLSELEAMVCGDVARLHAQLGEMRLERACLLDKLDQAHHFVKEAEDAQRELRTQLELQRIRGEKVHRELRRQLTRLVRSHQLESAEQSSLRKSSIYSSSSSLSSAVTPIPGASLTNGECSSLHPETPPPLDTSEAKRLEVPPGFFSLADFKALVDRLSEVQEENCVFRRHIQRLESEVVSKSKALQMELDKCIHGSSSSPSFCSPVSTARFDPTHHSVGPHPIGNSFSWFSSLKSAVAPGLTTNQHGISSTHLESINRLKRMCEQLVTENVQLTEELEKLRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1M1</accession>
    <name>A0A074Z1M1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597007">
        <property type="protein sequence ID" value="KER20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175294.1">
        <property type="nucleotide sequence ID" value="XM_009177030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1M1"/>
    <dbReference type="STRING" id="6198.A0A074Z1M1"/>
    <dbReference type="GeneID" id="20324776"/>
    <dbReference type="KEGG" id="ovi:T265_10608"/>
    <dbReference type="CTD" id="20324776"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="47730" checksum="C7A40D474C458C84" modified="2014-10-01" version="1">MAQWLELEVTDQKVCGSNPIYASPLLSRLAQRDSIPVLVPSSSGFQDLNISITRLDEQFDIDRPPIENSCTLPTFRFLMHSSNTDPVSLKWWDTHKEDCGVEHKFERPVLAFVLHFIARTFPLCRAMTVALETTDIPRTEVEELMEPSSDTSEPHLDGSSQPNTVESMLNRLATQEYVHFRNQSRDEAELSTSEKRNIASDLYRRNPGVFLERFGRHLNWAEDSVNFRHMCSKDDIVRHFVKQLDSQSDRTQFNQPLRLAQHQVRNRRLNALKRLDREGGTEHLSMEHFSHPAMRHRDPVLWETMIGAHLNEAGRRKYLDREYGTFSGFLMDVVLREQESKDWQRACREQESDATFEASSDSDESDGSVTPDGSVTLEGLEKEFMEIMRLRFVNGLDKDFDYMLMLGSYEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Y4</accession>
    <name>A0A074Z2Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pao retrotransposon peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597122">
        <property type="protein sequence ID" value="KER19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176371.1">
        <property type="nucleotide sequence ID" value="XM_009178107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Y4"/>
    <dbReference type="STRING" id="6198.A0A074Z2Y4"/>
    <dbReference type="GeneID" id="20325619"/>
    <dbReference type="KEGG" id="ovi:T265_11451"/>
    <dbReference type="CTD" id="20325619"/>
    <dbReference type="OrthoDB" id="10067762at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33510" checksum="BD68C5AC995F09D2" modified="2014-10-01" version="1">MCQTQKSLHIFSDTSEVGYGAVAYLRCESLRQVHCSFLVGKARVAPLKSVTIPRLGLQAAVLAVRLMRHLVKQLEVRFDNIYFWTDSMTVLHYIPGTSLRFKTFVANLISFIHENTNTSQWGLLLRLWIQGPEFLKLGEQHWPKTDIEQLHHKPTNLELKKAVTVLVNAVPDLPTDVLLSYHSSWLRLRRAAAWFTRNRSYLRSKRVGKDMELRNTLRPDELNEAERSILRYVQLKTFPSELSTTYGHVKGYIRNRRFTNYVQSFSMTRYVWVVDWAIALCQNPQSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3F6</accession>
    <name>A0A074Z3F6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596958">
        <property type="protein sequence ID" value="KER21553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174700.1">
        <property type="nucleotide sequence ID" value="XM_009176436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3F6"/>
    <dbReference type="STRING" id="6198.A0A074Z3F6"/>
    <dbReference type="GeneID" id="20324317"/>
    <dbReference type="KEGG" id="ovi:T265_10149"/>
    <dbReference type="CTD" id="20324317"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="10">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER21553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="24257" checksum="A257D7420EE8ACF4" modified="2014-10-01" version="1">MGGNTSAKNLNTIKSLRVLRVLRPLKTINRVPKLKYHRQEQKSSTHLTMDTEQQAYHNYCNTLLYFNSAFTVMFSIECMLKILAFGPKMSDNPSVRVAAMLSNSVIPGPLITSLDIQTEFRANGFIITFSDHFIFEQYEQKLVRMNMPVDENGCVQFTTTLFALIRESLAIKTGPTEIMDQRDNELRETICQMWPVRGRKMLNLLVPPDSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3X1</accession>
    <name>A0A074Z3X1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174467.1">
        <property type="nucleotide sequence ID" value="XM_009176203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3X1"/>
    <dbReference type="GeneID" id="20324134"/>
    <dbReference type="KEGG" id="ovi:T265_09966"/>
    <dbReference type="CTD" id="20324134"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37845" checksum="B569EA42F063DCD9" modified="2014-10-01" version="1">MYAFVESEHFAPLRKLFSLFKDMMGRHYEVKTFVVDKMTLQMRAAKAVFGCDIMLCYFHARQVIRKHCQGTPADFCQGHFPPVDQLVTIYTSHPLDQVLYMSKDRFPRIAPFISPSVGWRRSGYGGSMQYEKDRSAVTPFRCLAAQHGAMLPEGSMKAPTSQLDGVSNFRLAEWGRRCKANINDPEKCDCIAHSIVILRHSDRFYLLLSSPEYQISRNMGIYLSLPKEPNTEKIIQQALAGGRKIFVPQLLSQEYQSVNNLQGNASALLYTEFEFGLHRSRATCWDMGVSQFGINEEAINTGSREVGTVALYANDFTYWNKAQFRKPPPPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4L3</accession>
    <name>A0A074Z4L3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.168</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain alpha-keto acid dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.3.1.168" evidence="6"/>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER22008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174243.1">
        <property type="nucleotide sequence ID" value="XM_009175979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4L3"/>
    <dbReference type="STRING" id="6198.A0A074Z4L3"/>
    <dbReference type="GeneID" id="20323970"/>
    <dbReference type="KEGG" id="ovi:T265_09802"/>
    <dbReference type="CTD" id="20323970"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER22008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13128" checksum="62FCD1D3339209F9" modified="2014-10-01" version="1">MLCRSTYCIMQGRFVEVGDNVRQFDPVCEVQSDKATVTITSRYDGIVRALHFKPQDTCLVGQALVDIEVDNSSSNSDKRELHSVPVEVPDCIEPEANRIKVLATPSVRRLAAEYKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z511</accession>
    <name>A0A074Z511_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596916">
        <property type="protein sequence ID" value="KER22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174102.1">
        <property type="nucleotide sequence ID" value="XM_009175838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z511"/>
    <dbReference type="GeneID" id="20323851"/>
    <dbReference type="KEGG" id="ovi:T265_09683"/>
    <dbReference type="CTD" id="20323851"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="28133" checksum="FE41A4657D7AB1D0" modified="2014-10-01" version="1">MGTTIFKFTNVSCLLMQTESNSQKLEHTKPSKLDGVGHLEKTRSAFVGQTLAAVDITYAAIQCLKCHSFCLENMQANEFRTQLQCRISKEVCKSEYSPFAKLIRQLNVLHQAASCFSRYDIQLSENIKNERFSWVPATNFQLITTFMDQKVTRGDFEVNGSQSTLKNQAAPIRFAILQTKSFFVLAKYMVEHLNVPLRITACTTPKEPITMKKLLTSLLKTLPQSTTGFVLFGAHQVGPVPEFPSTLCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z542</accession>
    <name>A0A074Z542_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601302">
        <property type="protein sequence ID" value="KER18440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177813.1">
        <property type="nucleotide sequence ID" value="XM_009179549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z542"/>
    <dbReference type="GeneID" id="20330219"/>
    <dbReference type="KEGG" id="ovi:T265_16054"/>
    <dbReference type="CTD" id="20330219"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10800" checksum="BC8DDD5A985E079F" modified="2014-10-01" version="1" fragment="single">MSSVTILHRHSAVSHRLPLLEELNSRRFLSTSVHVPIAITQDYPKGTHFLQDLPIFIPFVLRYDLVPQLCQQFCSDQLAEERSSCTDNSPHNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5A4</accession>
    <name>A0A074Z5A4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175551.1">
        <property type="nucleotide sequence ID" value="XM_009177287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5A4"/>
    <dbReference type="STRING" id="6198.A0A074Z5A4"/>
    <dbReference type="GeneID" id="20324979"/>
    <dbReference type="KEGG" id="ovi:T265_10811"/>
    <dbReference type="CTD" id="20324979"/>
    <dbReference type="OrthoDB" id="6271773at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="740" mass="80028" checksum="1521B13AA6A1E350" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5K6</accession>
    <name>A0A074Z5K6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596903">
        <property type="protein sequence ID" value="KER22358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173890.1">
        <property type="nucleotide sequence ID" value="XM_009175626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5K6"/>
    <dbReference type="GeneID" id="20323698"/>
    <dbReference type="KEGG" id="ovi:T265_09529"/>
    <dbReference type="CTD" id="20323698"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7024" checksum="D1A8E9A3C54A832F" modified="2014-10-01" version="1">MIPGVYLSVLILRLTNGDEVNKGCPFYFLELNERKTECKSRKSVELRPIKARAYNLISGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5M1</accession>
    <name>A0A074Z5M1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_09477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KL596899">
        <property type="protein sequence ID" value="KER22431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173821.1">
        <property type="nucleotide sequence ID" value="XM_009175557.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z5M1"/>
    <dbReference type="GeneID" id="20323646"/>
    <dbReference type="KEGG" id="ovi:T265_09477"/>
    <dbReference type="CTD" id="20323646"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="9">
        <location>
            <begin position="351"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER22431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1554" mass="173434" checksum="EDAF03A6CD293AB9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5W9</accession>
    <name>A0A074Z5W9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173789.1">
        <property type="nucleotide sequence ID" value="XM_009175525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5W9"/>
    <dbReference type="GeneID" id="20329014"/>
    <dbReference type="KEGG" id="ovi:T265_14848"/>
    <dbReference type="CTD" id="20329014"/>
    <dbReference type="OrthoDB" id="6498117at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="478" mass="54523" checksum="32BEF860D9B5417B" modified="2014-10-01" version="1">MNRPSRKDSAPAENTLGKANKTYLESVEKYTHLQINLVFHRDSTESLVYDAPQLNALHTGRLMFQYTRRVFSRPLHHPCENFIVIINDSMTSVFNTDASLPYSHDLFQSFIVKKRIKAFTQAIWIETDNRNATDIAIDKNALIIKHLWGSFELLVCPSEVRICKRVRALCTEEADRTAARIEVKSKLRGSGYPASLIKRQLRRVLAPVGKPNREWIGTAVIPYKPGTSEVIRRILNTANIRFSKGGTLCTGLIEGSPPGKQPQTVYKIKCNDCTKDRRPESEHSRKINRPPRNADEYRALLKDSAIAEHALETGHKILRTCEDYGPRHRLITEAVEITKHPSVNRMEGVELASKDTEYGQRKTLRSVLLHLKDRLPVDRTRNCVYKIKRNNCTKVCIGQTARKLHTRIAFLNRPPRNADKSQAMAGHAVDTGHRIDFENVDILRRGLRFTPQRLVAEAVEIAKHPSVNVWRGILDQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z667</accession>
    <name>A0A074Z667_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/ethanolamine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_09332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596888">
        <property type="protein sequence ID" value="KER22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173629.1">
        <property type="nucleotide sequence ID" value="XM_009175365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z667"/>
    <dbReference type="STRING" id="6198.A0A074Z667"/>
    <dbReference type="GeneID" id="20323505"/>
    <dbReference type="KEGG" id="ovi:T265_09332"/>
    <dbReference type="CTD" id="20323505"/>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24998" checksum="03357221F2ED6D56" modified="2014-10-01" version="1">MAVSQLWCFLREAWHLGIGRMLQLNDRNLFSHLLFCCPDNLLLLNNPEEDGTYDLLPIDFEYAGYNYRGFDVGNHFNEWCFDYTNPDPPYFFYQYEAYPSEEDQKEFWKAYLRAWKMDRRKSAEASNLPCGDILSLINRIEDGDEELSVTFDHLWLEAWLGSLTSHIVWAAWSLIQTQLSSIRFRFDEYAAARMDAYFRLKSSGLAKFSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z750</accession>
    <name>A0A074Z750_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596873">
        <property type="protein sequence ID" value="KER22923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173343.1">
        <property type="nucleotide sequence ID" value="XM_009175079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z750"/>
    <dbReference type="GeneID" id="20323273"/>
    <dbReference type="KEGG" id="ovi:T265_09094"/>
    <dbReference type="CTD" id="20323273"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6196" checksum="DDEE4EB7F63B92E8" modified="2014-10-01" version="1">MLNTLLTDAYRLLETRIQDTGTVVGLTPTRSLLASSGDAETAVTGPVGDKDEDPVATTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7J7</accession>
    <name>A0A074Z7J7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597304">
        <property type="protein sequence ID" value="KER19165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177088.1">
        <property type="nucleotide sequence ID" value="XM_009178824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7J7"/>
    <dbReference type="GeneID" id="20326136"/>
    <dbReference type="KEGG" id="ovi:T265_11968"/>
    <dbReference type="CTD" id="20326136"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8728" checksum="AA6F69F3D6421183" modified="2014-10-01" version="1">MTICDVNILGKGHLHHYQIVFDYVWPLPAAADVDDDDEDDDDGGNDDDVDDDDDDDDDDDDDDDDDDDDATRGCKHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8I4</accession>
    <name>A0A074Z8I4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_08664</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172799.1">
        <property type="nucleotide sequence ID" value="XM_009174535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8I4"/>
    <dbReference type="STRING" id="6198.A0A074Z8I4"/>
    <dbReference type="GeneID" id="20322843"/>
    <dbReference type="KEGG" id="ovi:T265_08664"/>
    <dbReference type="CTD" id="20322843"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER23443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="17631" checksum="C359B8FD9D810B7B" modified="2014-10-01" version="1">MVNYKQEMPPPGGYKPIDVLKKAGKRPTNGLLVVAGLYTSTYFGLQYQKWLKNKRKTQEREEEEVRIALSPFVFAEQERMYLRQLRRNRDYEAKLMEDVPGWKVGHWHDVPLFHNPRGLWCDPNADEFYAHTTQKFRNRNLGVVHDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z903</accession>
    <name>A0A074Z903_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174189.1">
        <property type="nucleotide sequence ID" value="XM_009175925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z903"/>
    <dbReference type="GeneID" id="20323921"/>
    <dbReference type="KEGG" id="ovi:T265_09753"/>
    <dbReference type="CTD" id="20323921"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="17305" checksum="3C19C0B25BB20AAA" modified="2014-10-01" version="1">MWTSQSAKYALDKLWNEKRLIWIEIECIVQPSQQQWLECDSETNQSNFGRVVRRRKTIVHQSPVRVMLVLAKSTRMIKQRVPVRTDSFRKRTASAAEPNSGPTITRHSQHYIAVLYRQDILRYSCRLLPETLDLRIHYMFEYPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9H1</accession>
    <name>A0A074Z9H1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172376.1">
        <property type="nucleotide sequence ID" value="XM_009174112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9H1"/>
    <dbReference type="GeneID" id="20322523"/>
    <dbReference type="KEGG" id="ovi:T265_08344"/>
    <dbReference type="CTD" id="20322523"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6551" checksum="0D8811DB1ECE4993" modified="2014-10-01" version="1">MVNSTVPASAASGTIKMYTSALIYLAGLEQQELQTDEAIDKADIGEKKKAFDPELFIRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA90</accession>
    <name>A0A074ZA90_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172070.1">
        <property type="nucleotide sequence ID" value="XM_009173806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA90"/>
    <dbReference type="STRING" id="6198.A0A074ZA90"/>
    <dbReference type="GeneID" id="20322278"/>
    <dbReference type="KEGG" id="ovi:T265_08099"/>
    <dbReference type="CTD" id="20322278"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32836" checksum="C5E1B819C3254BD2" modified="2014-10-01" version="1">MDGIKKKMIAMKLEKENAMERAVQYEAQLKQKEEEQEKKETEIGELNNRMKQAQTELDEIQEALQDSLNKMEETDKRATNAEAEVAAMTRRIRLLEEDLEVSSSRLTETLAKLDEASKTAEESERGRKELEIRSIADDERLSQLEDQQKEAKYIAEDADRKYDEAARKLAIVEVDFERAESRLEAAESKIVELEEELRVVGNNMKALEISEQESAQREESYEETIRDLTERLKAAEQRAAEAERQVSKLQNEVDHLEDDLLAEKIRYKDLSGELDQTFAELTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAQ2</accession>
    <name>A0A074ZAQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172072.1">
        <property type="nucleotide sequence ID" value="XM_009173808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAQ2"/>
    <dbReference type="GeneID" id="20322280"/>
    <dbReference type="KEGG" id="ovi:T265_08101"/>
    <dbReference type="CTD" id="20322280"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER24163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="350" mass="40508" checksum="1EC98116BBBD3C32" modified="2014-10-01" version="1">MNKRAGYTAALLILTVCAVLLFQSRGPIITLRKESRFNWKVGPLTSKVQSNDTIHITQFIRGTRAALRAITMLKSLLYFQNRFHSNTSNCAPFEPFGNSSCAEKIHPPQNIIHMHLVCDRNLWTMLESQLQNCSLPYLKCSFYDVESYVNFAQRIPNGHITGPTPVAKLWIPYILPPWVIKTIVPDSDMLWNENPLMLWKIFEQFNPTQMIELAWEQQSYDPLCSEDQIKPLPEVYSFLIRMKPDWYYRIPCEWNTQVYSAVAVHCCPIIWPDRRPDVSHRCFDVADNKSFVIGALVHYDTPLKPEEPGWENSVVAGTPRSGDVLTIDQLRSRFLDVYTRFQRIPMSCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB68</accession>
    <name>A0A074ZB68_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171704.1">
        <property type="nucleotide sequence ID" value="XM_009173440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB68"/>
    <dbReference type="GeneID" id="20321990"/>
    <dbReference type="KEGG" id="ovi:T265_07811"/>
    <dbReference type="CTD" id="20321990"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="37" mass="4218" checksum="A042E4118E2957FA" modified="2014-10-01" version="1" fragment="single">CLALSVFLNIHGFAYQFGGHVYDIPRLNVLHKSRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBB7</accession>
    <name>A0A074ZBB7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Identified in the spliceosome C complex. Interacts with SNW1/SKIP. Interacts with CDC40/PRP17; this interaction leads to CDC40 isomerization. Interacts with RBM22.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KL596804">
        <property type="protein sequence ID" value="KER24591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171661.1">
        <property type="nucleotide sequence ID" value="XM_009173397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBB7"/>
    <dbReference type="STRING" id="6198.A0A074ZBB7"/>
    <dbReference type="GeneID" id="20321964"/>
    <dbReference type="KEGG" id="ovi:T265_07785"/>
    <dbReference type="CTD" id="20321964"/>
    <dbReference type="OrthoDB" id="5916692at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21065" checksum="5C5627E9496A4C80" modified="2014-10-01" version="1">MPMFKSILFAQNTPTNDRPATLCPSGNNVCYIIFPFTHPLSQGTVAVELYWKHAPKTCMNFAELAKRGYYNNVSFHRIIRDFMIQGGDPTGTGRGGASIYGNYFEDEIHPDLKHTGAGIVSMANAGPNTNGSQFFITLAPTQWLDGKHTIFGRVASGMKVVQRMGMVDVDHMDRPKDPLRIIKAHTAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCJ6</accession>
    <name>A0A074ZCJ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597009">
        <property type="protein sequence ID" value="KER20925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175328.1">
        <property type="nucleotide sequence ID" value="XM_009177064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCJ6"/>
    <dbReference type="GeneID" id="20324802"/>
    <dbReference type="KEGG" id="ovi:T265_10634"/>
    <dbReference type="CTD" id="20324802"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="341" mass="38553" checksum="A16E9E1BA8C3741B" modified="2014-10-01" version="1">MYKTTRTYCSSPPKPRDSVNLPTEENAKFIELCIFAHEYLLCLVVGDGRSRRGNTATDAAGASHSSEAQIRCCSSVLWTNNFQLTELPNVEAKRCHINAWVAENTKDKIRDLLPPSFLDQNSKFLLINALYFRGSWEHQFDKKKTQESDFHCLNGESMKVQMMYKKSRFNLAYLAELDCMAIKLPFRRSDSQSEWALLILLPHERAGLPKLLSKLRAPGQLASAMGCKFYMENAHLYLPKFKLADEPMIDLKPILYECEMKKLFEGAGLSRLSKSFLSVTDAYHKALDEEGVTAAAATLFTQSFSTRLPETISVDHPFFFALVCDSAVPVFVGHVVAPNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCR2</accession>
    <name>A0A074ZCR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171195.1">
        <property type="nucleotide sequence ID" value="XM_009172931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCR2"/>
    <dbReference type="STRING" id="6198.A0A074ZCR2"/>
    <dbReference type="GeneID" id="20328450"/>
    <dbReference type="KEGG" id="ovi:T265_14284"/>
    <dbReference type="CTD" id="20328450"/>
    <dbReference type="OrthoDB" id="9873027at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER25071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="36921" checksum="A374456F7543C35D" modified="2014-10-01" version="1" fragment="single">TDVDEAYGTSSVTINVQGEVGENAHLKVSKTAEISTWQAESPDSSQNPEEPVDQALTYRCPICGRGFQHQSHLLRHQDSHATERFFKCNIQTLPSKHVDEAYGTSSVTINVQGEVGENAHLKVSKTAEISTWQAESPDSSQNPEEPVDQALTYRCPICGRGFQHQSHLLRHQDSHATERFFKCNMCSSTYKHQSDLAKHKRKRHVDEYVPRDKSTREQILASEQAGHPCLECGKQFKHWRNMKKHRRIVHPGTAGLVCEKCGMSFPRELHLNRHIRQVHERENKFPCPHCPQSLSYARTLMLHIRNMHKPEQADETPVGQQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCW8</accession>
    <name>A0A074ZCW8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596786">
        <property type="protein sequence ID" value="KER25121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171109.1">
        <property type="nucleotide sequence ID" value="XM_009172845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCW8"/>
    <dbReference type="STRING" id="6198.A0A074ZCW8"/>
    <dbReference type="GeneID" id="20321525"/>
    <dbReference type="KEGG" id="ovi:T265_07346"/>
    <dbReference type="CTD" id="20321525"/>
    <dbReference type="OrthoDB" id="6151507at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="652"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="848"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER25121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="936" mass="101263" checksum="20784765384428CC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF61</accession>
    <name>A0A074ZF61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170331.1">
        <property type="nucleotide sequence ID" value="XM_009172067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF61"/>
    <dbReference type="STRING" id="6198.A0A074ZF61"/>
    <dbReference type="GeneID" id="20320909"/>
    <dbReference type="KEGG" id="ovi:T265_06730"/>
    <dbReference type="CTD" id="20320909"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="13672" checksum="258C32E1F0169E13" modified="2014-10-01" version="1">MCPYCKRSFYYDLTSLKVDKGPVCHSEFANISVSRWPKWLECEFTDRKVRGSNPTSATRLPLSRLGQPGSIPALVLPSGGMAARHRKGATAERFLSFFLSSSINHSCPTDREDNVVFSFVGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHQ9</accession>
    <name>A0A074ZHQ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173440.1">
        <property type="nucleotide sequence ID" value="XM_009175176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHQ9"/>
    <dbReference type="STRING" id="6198.A0A074ZHQ9"/>
    <dbReference type="GeneID" id="20323344"/>
    <dbReference type="KEGG" id="ovi:T265_09165"/>
    <dbReference type="CTD" id="20323344"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005104646" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="125"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="364"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="480" mass="54510" checksum="87DEC6A77165F503" modified="2014-10-01" version="1">MLQLLWLLLIWRPICAKSQEAAPEQVHLALGDRADIIVVTWVTLLPTNSSIVLYGTSELLLQTATGSHTTYVDGGTEERVFYNHRVTLQDLLHGYRYYYKCGDGSSWSQTFTFRALADHPFWSPRLAIFGDMGITDNLALPELVREINEKDSFDVILHNGDFAYDMDTNNSRFGDIFMKQIEPIASAVPYMTAVGNHEQAYNFSNYKARFSMPGGDGESQFYSFNIGPAHIISFSSEFYYYLSYGWRQPFRQYDWLEQDLLDANKPENRQLRPWIIAFGHRPMYCSNNDDAMHCDNVNNIVRTGFPYGKNGSSGYSLGLEELFYQYGVDIIIGAHEHSYERFWPVYNLKVCNGTPENPYLNPPAPVHIVTGSAGCSEGMDPFTPGGKPWSAFRSDDYGFTRMHIHNKTHLSVEQISVQQGPNGVVIDSFTIVNSHHGKDQFTCHLEPESQEKPWTAIQPAKKAILRNVGTSRAWARLFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHR4</accession>
    <name>A0A074ZHR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173458.1">
        <property type="nucleotide sequence ID" value="XM_009175194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHR4"/>
    <dbReference type="GeneID" id="20328945"/>
    <dbReference type="KEGG" id="ovi:T265_14779"/>
    <dbReference type="CTD" id="20328945"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="138" mass="14625" checksum="F7AD1DA37FABCCCD" modified="2014-10-01" version="1" fragment="single">METPDMWSDQSTTSSISVSPVERVRPFRRADSGELQRKLGLKVLNLGGNSVIGYQLHFDLEGETGVVVRGIGTAVRLRKQTAPRSPPSSPVGAPPRLPGSIELNTESPVGSADTPSALEREAPFKGSTGNLSQAMELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHW3</accession>
    <name>A0A074ZHW3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169352.1">
        <property type="nucleotide sequence ID" value="XM_009171088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHW3"/>
    <dbReference type="GeneID" id="20320123"/>
    <dbReference type="KEGG" id="ovi:T265_05941"/>
    <dbReference type="CTD" id="20320123"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11774" checksum="F6555A5AF023BD7F" modified="2014-10-01" version="1">MMRKIQVIQTRKLGSVVNPIIYKLDQALIMTFLGTRSKCPPHTHEERCRKRYDNFGENYVVNMTTKSDVVSKKTGLRLNSYCQFCNALFTHSMIAKVYRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHX8</accession>
    <name>A0A074ZHX8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuole membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596874">
        <property type="protein sequence ID" value="KER22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173353.1">
        <property type="nucleotide sequence ID" value="XM_009175089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHX8"/>
    <dbReference type="STRING" id="6198.A0A074ZHX8"/>
    <dbReference type="GeneID" id="20323280"/>
    <dbReference type="KEGG" id="ovi:T265_09101"/>
    <dbReference type="CTD" id="20323280"/>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38817" checksum="6A1E604228EAA95F" modified="2014-10-01" version="1">MDPTLKYVSLSSNYLLGLSTPTENHTVVGVVGMVRFSFLLWIWYGASYICAVPCKTRRLFLTRFQGPFIAEVTMSAYECKTLKFPRPPYPDRIICPEGAFLEERITFWRIMRKVQMESIMWGIGTAIGELPPYFMARGARLSDRHNDEDLKELEEILATEQTSDSVHTKDLSFQKRAELLLHRLIIRAGFVGILLCASVPNPLFDLAGMTCGHFLVPFWSFFGATVIGKAIIKVHLQQFTVIALSSEHHVESLVHLMGRIPVYGRSLQAPFLEYLQQQKANLHNKVTTTHQSWLQTIIFLIVSGLICSFVVSIIHALANKYQRRLRQWQRLAEAENLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI38</accession>
    <name>A0A074ZI38_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596776">
        <property type="protein sequence ID" value="KER25457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170783.1">
        <property type="nucleotide sequence ID" value="XM_009172519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI38"/>
    <dbReference type="GeneID" id="20321260"/>
    <dbReference type="KEGG" id="ovi:T265_07081"/>
    <dbReference type="CTD" id="20321260"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10298" checksum="CCE5D1109B36F25A" modified="2014-10-01" version="1">MTLLIYLGNYRYCTAVNYGTRTTKISSIRWSKAHDWGLTKKQTTHLVDLISSYGYGHYTDSSQLSDSFHVAVSVGVRRLFGLPCWCQEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIP4</accession>
    <name>A0A074ZIP4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596737">
        <property type="protein sequence ID" value="KER26871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169418.1">
        <property type="nucleotide sequence ID" value="XM_009171154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIP4"/>
    <dbReference type="GeneID" id="20320184"/>
    <dbReference type="KEGG" id="ovi:T265_06002"/>
    <dbReference type="CTD" id="20320184"/>
    <dbReference type="OrthoDB" id="10440908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="17585" checksum="3ECC62FEBB706C31" modified="2014-10-01" version="1">MDPFRHDSFLALGFSRQYDPKTSAVLAELRESFAELDEEDGDWHWKWQSTRQRREDKWKFVVSLYPWMDGALAVSITSEEDDNRPDYRYTECARVTEDEEVASQEDNHRSVCGSLGCAPISMVDTHSSDDDGAHSHCGVFLGCAPLTTCGVNVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIR1</accession>
    <name>A0A074ZIR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_08863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596860">
        <property type="protein sequence ID" value="KER23215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173044.1">
        <property type="nucleotide sequence ID" value="XM_009174780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIR1"/>
    <dbReference type="STRING" id="6198.A0A074ZIR1"/>
    <dbReference type="GeneID" id="20323042"/>
    <dbReference type="KEGG" id="ovi:T265_08863"/>
    <dbReference type="CTD" id="20323042"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="326"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="326"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER23215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="606" mass="68623" checksum="CAC335910700D18B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIY8</accession>
    <name>A0A074ZIY8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172953.1">
        <property type="nucleotide sequence ID" value="XM_009174689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIY8"/>
    <dbReference type="GeneID" id="20322968"/>
    <dbReference type="KEGG" id="ovi:T265_08789"/>
    <dbReference type="CTD" id="20322968"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8101" checksum="E032AB44371DB514" modified="2014-10-01" version="1">MDRFSLYPTDLRSSSKNAVEHRRGFPMSLRNKDQRRNTRNTPNLLSSRPKSKKQSSALTALIAGGQQQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJP1</accession>
    <name>A0A074ZJP1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168643.1">
        <property type="nucleotide sequence ID" value="XM_009170379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJP1"/>
    <dbReference type="GeneID" id="20319563"/>
    <dbReference type="KEGG" id="ovi:T265_05381"/>
    <dbReference type="CTD" id="20319563"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7103" checksum="BF24EA983979BEB6" modified="2014-10-01" version="1">MKRCTSVFDFGLGTNIPCVPLTEKSSVVRSMQNTSMTEHKTVLFSLSRFANIYVLGCPGCHPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJX0</accession>
    <name>A0A074ZJX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168604.1">
        <property type="nucleotide sequence ID" value="XM_009170340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJX0"/>
    <dbReference type="STRING" id="6198.A0A074ZJX0"/>
    <dbReference type="GeneID" id="20319531"/>
    <dbReference type="KEGG" id="ovi:T265_05349"/>
    <dbReference type="CTD" id="20319531"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF151">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="493" mass="55601" checksum="2E2DC5E3B896A11E" modified="2014-10-01" version="1">MEMELFEDWLNGGVDWPHPGRNLLLLSSHMDQYGRGLVSRTSISPGDCCLAIPSNDFKVVLTPFRCANMMNFCGCFRQLQISISLNPFDVLVLFIHHLIRPWLPNCPLASIWKPYVSLLPSHYTDPTFVPTSNACRGISAEPFSFRSQDIQISIQKSLERFQSTYDACGPLLSASASSLSNTAPATVEFAWAWSTVNSRCVYCQLHETCSPPISTFISSMATFLQVPVEQYCERIKLIPDRYSDTALIPFFDFLNHCPLVDSKLEVDRKGEAIQLFVQQSFGTGEQVLINYGPHDNLTLFIEYGFSLLPYENPHNAVYPSNIDLLQFFTSEYYHSVAQPTSTSTIKWEPQLCLILHDVLEQLGLPQASLSTSPVTWPSLCFSFEGASFHLSLLSYCVHHAVLSGCRYSELPSSLSASHSIFSLPEQEVSSVVQKPLNNLAKQLLRDTTLDEQQLQSLVLKIDSSREMVILRQCYDEFKKVLLSRRSVLENFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK04</accession>
    <name>A0A074ZK04_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172597.1">
        <property type="nucleotide sequence ID" value="XM_009174333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK04"/>
    <dbReference type="GeneID" id="20322691"/>
    <dbReference type="KEGG" id="ovi:T265_08512"/>
    <dbReference type="CTD" id="20322691"/>
    <dbReference type="OrthoDB" id="6238737at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25493" checksum="2664B95392EE6DC4" modified="2014-10-01" version="1">MIDAVKMGFRRLLPEGAPRRSKADGTVVLQKYVSHRSLVPNTMKSSLIEMQTNSTFRGLPELYLLHEGCAIVGELLQSSRLVDTGIAPVVLQPSQTKLNSEPPLWLRRLLGHPSFYDLPVHIHRTKLYIPAPIFYKSDKNNPIHFTSILPTPRGQISCSRQRTSSSFTGLSWTKLEDSEGANPKTSYILTCTSPWLPEYFPYTMDRLGLKFDYTSWISSETYSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKZ7</accession>
    <name>A0A074ZKZ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tctex-1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169814.1">
        <property type="nucleotide sequence ID" value="XM_009171550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKZ7"/>
    <dbReference type="GeneID" id="20328160"/>
    <dbReference type="KEGG" id="ovi:T265_13993"/>
    <dbReference type="CTD" id="20328160"/>
    <dbReference type="OrthoDB" id="6228263at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15404" checksum="84D38A484DD9D19A" modified="2014-10-01" version="1" fragment="single">MLGALRARVKARKQNTYQICPPPVFTFAKNRKVVAEQLEESLNTYLGQVEIDEKGTISPPFTDFLNSLRDTLCVKQQKMFPRHKLIVHGIIGTTGDNEPTISFATHTFMSLECGDDVVGLSVKNPVCYIAVMVAGFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLZ5</accession>
    <name>A0A074ZLZ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167885.1">
        <property type="nucleotide sequence ID" value="XM_009169621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLZ5"/>
    <dbReference type="GeneID" id="20327766"/>
    <dbReference type="KEGG" id="ovi:T265_13599"/>
    <dbReference type="CTD" id="20327766"/>
    <dbReference type="OrthoDB" id="6252630at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="541" mass="58824" checksum="8F3B0AD5C17F1647" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMJ3</accession>
    <name>A0A074ZMJ3_OPIVI</name>
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        <recommendedName>
            <fullName evidence="8">Peptidylamidoglycolate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167955.1">
        <property type="nucleotide sequence ID" value="XM_009169691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMJ3"/>
    <dbReference type="GeneID" id="20319027"/>
    <dbReference type="KEGG" id="ovi:T265_04845"/>
    <dbReference type="CTD" id="20319027"/>
    <dbReference type="OrthoDB" id="10018185at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14958">
        <property type="entry name" value="NHL_PAL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705471" description="Peptidylamidoglycolate lyase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="4">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43810" checksum="8189FA95EFCF06D5" modified="2014-10-01" version="1">MRFSWILIHLCVQISASQLFEDGEFDSRELGSPGNIISESNDDRYFSRDEPRVSIIDVPEWPNREALHHLGDISASAPLDEEGRDVLVLHRGDREWNLLTFDEHNVLRDQSKGPIKDGVLALLHKGVLRETSLPNTFYMPHGLTVDPEGNIWVTDVGLHQVFKFSPDKTQLMVLGEKFKPGNDSGHFCKPTHVAVASTGDFFVSDGYCNNRIVKFRSDGTVITQWGKKVRSHETPGPYELNVPHELVLLEDSDTLCVADRENRRVVCYCAGLTPETEHLAGEYRYEIREPGPVYGVAVSPAANALVILVNQNNEQGSVDIRLYDLDTKERLGILADEDEGYGKAHTVSACTGDSEQGCIIVNSLNKAGQQKDARNKSVRRRLWLYEVQAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMZ3</accession>
    <name>A0A074ZMZ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009173282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMZ3"/>
    <dbReference type="STRING" id="6198.A0A074ZMZ3"/>
    <dbReference type="GeneID" id="20321873"/>
    <dbReference type="KEGG" id="ovi:T265_07694"/>
    <dbReference type="CTD" id="20321873"/>
    <dbReference type="OrthoDB" id="10257076at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="25923" checksum="B8867298C0FE0DC4" modified="2014-10-01" version="1">MAFLEAIRSAETEDIQCSLRRVRWVGHAVLKDESIASTGRNALHWAACGGHLDLVEKLIASGVDKDCKDQSDWTPLMIAVSAGRTQVAKFLIEEARADVNAVNSTGQRPMHYAASKNRLEIAQCLLSAGARVDIRDWGGTTPLHRAVSQGNLDMVKLILEQASSTDVTNIADNEGSTPLHYACEEDNMSAVRLLLDAGASVSYKNKAGKTPLDVAPDVLRLNLTKLLTETGVLRIKIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN01</accession>
    <name>A0A074ZN01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167468.1">
        <property type="nucleotide sequence ID" value="XM_009169204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN01"/>
    <dbReference type="STRING" id="6198.A0A074ZN01"/>
    <dbReference type="GeneID" id="20318637"/>
    <dbReference type="KEGG" id="ovi:T265_04455"/>
    <dbReference type="CTD" id="20318637"/>
    <dbReference type="OrthoDB" id="6257961at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="17000" checksum="57BDC8DDE106C6DB" modified="2014-10-01" version="1">MTVHARPLPSSVVGELQHPGVDPIMSHRTHKLSRAAEQTSFSESYVIVEPQVNAGNCVPMDTKLEDSLLPEDIINDVFDLETMVVAKQQQQQQLSAKDCGLRNNCSYSTYSPNLLELDAPRDLNTYPSTASSSPSPCSPRLSNTIPPDSRSYLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN34</accession>
    <name>A0A074ZN34_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167724.1">
        <property type="nucleotide sequence ID" value="XM_009169460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN34"/>
    <dbReference type="GeneID" id="20318851"/>
    <dbReference type="KEGG" id="ovi:T265_04669"/>
    <dbReference type="CTD" id="20318851"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="410" mass="46567" checksum="E36E27027925243B" modified="2014-10-01" version="1">MFTAAREGRSRFDLRSNPSIVTTRTVTGSSFDESNTPIRLFKCEHVRLFRCDNSNASNVHWWSSGYGLASHVRCPGFKSRHALIRAKLESSASLWCGLTEIITPEQGYGRSNESGVAMNKDTHPAKPQNCNYSRSCSHQRSPLLVVFKEPLLKYSIPTGHNTSRKRRMMAQLKVPAAVSWDVSRHNKLGAMNLTSSIFFHRCCQTSRTEETINDYPIKRRRLRLFVQHNHTPAYPATVASTLLEVRNREPRKRARVQSVRSKYLSSASLFLTDNRYQCRGNEAYEQELLCANIEGDQVDSFKSHFEVLRIVTELRRTEAAAECDAWRATRTVLGLGTVEKQSNLAKYGKRESVRREASVVACFRLTTLLYAASKVTRLMALLVGRCSMRVLLIVDVTVVRRPGYCRDAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZND8</accession>
    <name>A0A074ZND8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167613.1">
        <property type="nucleotide sequence ID" value="XM_009169349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZND8"/>
    <dbReference type="STRING" id="6198.A0A074ZND8"/>
    <dbReference type="GeneID" id="20318756"/>
    <dbReference type="KEGG" id="ovi:T265_04574"/>
    <dbReference type="CTD" id="20318756"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="121"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="571" mass="63150" checksum="3816AA1CB915E016" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP91</accession>
    <name>A0A074ZP91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_04068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166978.1">
        <property type="nucleotide sequence ID" value="XM_009168714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP91"/>
    <dbReference type="STRING" id="6198.A0A074ZP91"/>
    <dbReference type="GeneID" id="20318254"/>
    <dbReference type="KEGG" id="ovi:T265_04068"/>
    <dbReference type="CTD" id="20318254"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="repeat" description="PPR" evidence="9">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="692"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER29218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="788" mass="87704" checksum="39ED990D805AF5AE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRL6</accession>
    <name>A0A074ZRL6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166548.1">
        <property type="nucleotide sequence ID" value="XM_009168284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRL6"/>
    <dbReference type="GeneID" id="20317924"/>
    <dbReference type="KEGG" id="ovi:T265_03737"/>
    <dbReference type="CTD" id="20317924"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7645" checksum="479BEAE266EC3C26" modified="2014-10-01" version="1">MAEPIAGQLCFGGLRLTQLQQRVQVGAGQNVSDANEHHTQWIQEEEEFANGCAHVEHVKRRFQLGELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSF7</accession>
    <name>A0A074ZSF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167463.1">
        <property type="nucleotide sequence ID" value="XM_009169199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSF7"/>
    <dbReference type="STRING" id="6198.A0A074ZSF7"/>
    <dbReference type="GeneID" id="20318632"/>
    <dbReference type="KEGG" id="ovi:T265_04450"/>
    <dbReference type="CTD" id="20318632"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="87"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="301" mass="33860" checksum="7DB23D932C8E85EC" modified="2014-10-01" version="1">MPGIHTIRQRAHGAHRSLKRQRLKSLKEDRELWWTSEAREIEKAFAARNGRTLHQLKRSTGQRKAVVSDMISEASGSILPMENIYPHVVRRISKEIREVLDDTLDGIKLVVNEQDLTDIQAIIDGPADTPYEGGKFGVKLVLSERYPIEPPKGYFYTKIFHPNVAPVTGEICVDTLKRDWKSELGLKHILLVIRCLLLDPNPESALNEEAGKLLQEDYAEYVAQARLYTEIHACHHLRGLNPSSQQMLDEGAPAVHPKQSTNTGEQNGILRDTNGPSPKKPTTQKAAQRHISAAKKALKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSH6</accession>
    <name>A0A074ZSH6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165895.1">
        <property type="nucleotide sequence ID" value="XM_009167631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSH6"/>
    <dbReference type="STRING" id="6198.A0A074ZSH6"/>
    <dbReference type="MEROPS" id="C01.044"/>
    <dbReference type="GeneID" id="20317399"/>
    <dbReference type="KEGG" id="ovi:T265_03212"/>
    <dbReference type="CTD" id="20317399"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="368" mass="41744" checksum="26CC97581A593038" modified="2014-10-01" version="1">MLFGLSSLVYICGLFTVSASPELYDWDVLLLSNNKSDLVQKVSPDHCMELLNEDMQYIVTVAWEQFKREFNKTYADNQEHDKRFKLFCQRFMAVREHNKAYREGKVTFEKGINPFSDQTIEEISLKCCGIPSHNLTTVRGFKYRKLGVELPAHVDWRERGAVTRVRSQGTCGSCWAFSVTAAIEGHDFLHSNVLKRLSPQQLVDCSTAYGTKGCWGGHPPDAYRYVTDAGGVELDSDYPYVAEQQKCRFDRNKVVTRITGFVEIPNDEKILQEAVALYGPIAVAIDALHHSWVDYTKGVISEPKCKNARYDTNHAILLIGYGTDEDGTPYWLIKNSQGTWWGEQGYGRIIRNANNMCGIASYANYPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT01</accession>
    <name>A0A074ZT01_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167312.1">
        <property type="nucleotide sequence ID" value="XM_009169048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT01"/>
    <dbReference type="GeneID" id="20318521"/>
    <dbReference type="KEGG" id="ovi:T265_04339"/>
    <dbReference type="CTD" id="20318521"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005159303" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10398" checksum="60FA825C681650FA" modified="2014-10-01" version="1">MSGLLMLVHRLFPWLMMDNIWFRIIRTPEENARRVTTCIFTTNQQTTATRLRNHSGEFSNDVAWEPSTGVPVHRGTLTISEDLTKFIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT44</accession>
    <name>A0A074ZT44_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter, major facilitator family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_13972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169703.1">
        <property type="nucleotide sequence ID" value="XM_009171439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT44"/>
    <dbReference type="GeneID" id="20328139"/>
    <dbReference type="KEGG" id="ovi:T265_13972"/>
    <dbReference type="CTD" id="20328139"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER26550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51572" checksum="A22BBF2E85D07E18" modified="2014-10-01" version="1">MGYTKARVQKDVNDGLTIWLSALALCVQGICMPIGGMIANKIGFRIVVGISCIFESVFNLVTVEWRLFLPVSIAFTDLICSVGVLLTYFTIQKTFVGVIVTYALLNGVGLGLGYSVVLAVATSWFPARRGLVSGLIVGGFGLGALIFTPIQTAYINPDNVKVDNVTREFTDPILLDRVPNVFLLLGGLLLGIQTVGFILLRPRPTTTEKPEDQELNEQKTPLSAQAEVSDCAQHMEKTGSKTNLESTKERPDPIREDNLVPSQVLRHRDFYRLWIVMFCDIIPITIITSAYKYFGQTYISDDRALSAVATVSALFNSGGRMMWGAIVDRISFKIPMCCMLAMWSLILFTFPHLKYLEENTLKVFYGIWICLLFVCISGVFSIMPTATGSLFGPANMAVNYGLVYSAVSVGTLVCALVSTFVSSKGAYVVQFTSCGFISLIALCVTLTIEDKRMNKKYDVCLSCKNRCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTC2</accession>
    <name>A0A074ZTC2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165889.1">
        <property type="nucleotide sequence ID" value="XM_009167625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTC2"/>
    <dbReference type="GeneID" id="20317393"/>
    <dbReference type="KEGG" id="ovi:T265_03206"/>
    <dbReference type="CTD" id="20317393"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="14455" checksum="E20D2AD31F64015B" modified="2014-10-01" version="1">MCPSVGECSATYAGRLKRCLSIIILQSGGCSPKEPSPKARAPSVDCYGYGAVNSNSLLQKKLLAFWYVDVSGDIYSSILGIETALLSITSSTRNVGVVEFRVYSLRLLHILKREVHQTAIASVVATTAVNKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTM2</accession>
    <name>A0A074ZTM2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167091.1">
        <property type="nucleotide sequence ID" value="XM_009168827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTM2"/>
    <dbReference type="STRING" id="6198.A0A074ZTM2"/>
    <dbReference type="GeneID" id="20318343"/>
    <dbReference type="KEGG" id="ovi:T265_04157"/>
    <dbReference type="CTD" id="20318343"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="419" mass="47582" checksum="6F5D78BCC11B12A0" modified="2014-10-01" version="1">MYMEDFEQKALNGLECPPRVFWRYVDSTFVVIKWDKVNEFFQHLNTLDPHIKFSMELESTSGTLAFLDCMTHKSGGKLKPTVYRKSTDSSAVLNYSSAHPQAVYASIASAMFRRVRALCTEEVDRRAAQVEVKKRLQANGYPVGLIKRQLRRVVVPTPRRNKELIGTAVIPYKAGTSEVIRRVLNTANIRDRLPVDRTRNCVYKIKCHDCTKVYISQTARELHTRIGEHKRSINRPPRNAEEYQAHSVTIAAESSFNLLGCAVWLLVYSPSLTVGLQTFHHQSRLERQPCTDDVTSIGDETSAIQLPRVSGFSGRYSGKKSGQIKPSLSFTWSFLLISVYQKILRKKRHQPNRLKARWLSGKSANLLTGMSVVRTRPLPLDFSSLGLGNLVVSQPSCFPLVPWQIGTERVLQLNCYNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUG1</accession>
    <name>A0A074ZUG1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169241.1">
        <property type="nucleotide sequence ID" value="XM_009170977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUG1"/>
    <dbReference type="GeneID" id="20320038"/>
    <dbReference type="KEGG" id="ovi:T265_05856"/>
    <dbReference type="CTD" id="20320038"/>
    <dbReference type="OrthoDB" id="6247999at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17517" checksum="A21FC7D6C7CAB98B" modified="2014-10-01" version="1">MEGSYRLYQISIQTIKHQNGTTISNEEERLDRWAEHFEQQMSWPPAGTHLQPTGEVEPWTVNVEPPTASEVYDCICSLKRHRAPGWGPCDPHCAWLETLQDMAANQSQWRSCCQFLSRLPEPSNQSWLYGSEASVLDTDVKLSMMRMMMRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUT4</accession>
    <name>A0A074ZUT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166642.1">
        <property type="nucleotide sequence ID" value="XM_009168378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUT4"/>
    <dbReference type="GeneID" id="20317994"/>
    <dbReference type="KEGG" id="ovi:T265_03807"/>
    <dbReference type="CTD" id="20317994"/>
    <dbReference type="OrthoDB" id="6277910at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13599" checksum="8929917E349D6D97" modified="2014-10-01" version="1">MDVPMAHWVLESRTGRPHEPYANRTPLGWVLFGPIRPRTKNSYRKPYFSTSQKHLIGSHTSAAPQTPVLRDSRNNPSPDQGVLIRQIIPSENRLDRLLFSASLHWSYSRLRLGTNPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUV0</accession>
    <name>A0A074ZUV0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165057.1">
        <property type="nucleotide sequence ID" value="XM_009166793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUV0"/>
    <dbReference type="GeneID" id="20316718"/>
    <dbReference type="KEGG" id="ovi:T265_02530"/>
    <dbReference type="CTD" id="20316718"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6549" checksum="9B3A7AD3C88C5BB8" modified="2014-10-01" version="1">MSTNRASWVYGLGLPDLRIEMQLGPEPSLAEMQMKNRPSVHQNAAFVRSLNHHAEASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV90</accession>
    <name>A0A074ZV90_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164926.1">
        <property type="nucleotide sequence ID" value="XM_009166662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV90"/>
    <dbReference type="STRING" id="6198.A0A074ZV90"/>
    <dbReference type="GeneID" id="20316617"/>
    <dbReference type="KEGG" id="ovi:T265_02429"/>
    <dbReference type="CTD" id="20316617"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="708"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1251" mass="137538" checksum="5DB9647481A815C2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVA6</accession>
    <name>A0A074ZVA6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166517.1">
        <property type="nucleotide sequence ID" value="XM_009168253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVA6"/>
    <dbReference type="STRING" id="6198.A0A074ZVA6"/>
    <dbReference type="GeneID" id="20327471"/>
    <dbReference type="KEGG" id="ovi:T265_13304"/>
    <dbReference type="CTD" id="20327471"/>
    <dbReference type="OrthoDB" id="10249205at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER29787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="339" mass="37944" checksum="6A5D9A25AD741685" modified="2014-10-01" version="1" fragment="single">FEEAQKSGPHPLGGEIVDRCFDGYQLLHFSRPKTIDEVAYQTEVVSVLRKCVEGADLPNLLFYGPPGTGKTSLILAVARQIFGPLYSERVLELNASDERGINVIREKVKTFAHLAVSSGTGMGSSAKIPPYKLIVLDEADSMTAPAQAALRRTMETETRTTRFCLTCNYVTRIIDPITSRCAKFRFRPLDNEVARDRLRHICDEERLDIEDEVLDHVLQLSHGDLRRAITMLQSVCQLWHPVNRTVTKDHFDEVAAVVPDKMINSLLKAATAGRFDDLQLQIKLIGVNGPPASETVKDRNGVNISNEEERLNRWAEYFEQQFSRPSAGTPLEPTGNVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXD5</accession>
    <name>A0A074ZXD5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164089.1">
        <property type="nucleotide sequence ID" value="XM_009165825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXD5"/>
    <dbReference type="GeneID" id="20315923"/>
    <dbReference type="KEGG" id="ovi:T265_01735"/>
    <dbReference type="CTD" id="20315923"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="16892" checksum="A0C5528A4619BB18" modified="2014-10-01" version="1">MWTCIGNGNSLDRDMRINGSYLCLNLWFYTGCAPVTKAEEVASQKDNLRSVCGSLGCAPTSVDSRDLSEDNGAHSHCGFLGCALKTTCEQTVPPTTGAGFYGEPVYPSVEVTHMGVIHFQTVSTQCLRFMKLLAWKKRLDAWRSGFSICVCYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY20</accession>
    <name>A0A074ZY20_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168077.1">
        <property type="nucleotide sequence ID" value="XM_009169813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY20"/>
    <dbReference type="GeneID" id="20319127"/>
    <dbReference type="KEGG" id="ovi:T265_04945"/>
    <dbReference type="CTD" id="20319127"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12645" checksum="BD7F80F0F7943982" modified="2014-10-01" version="1">MAARRTSNAVCNATPARPGGISNARRAATRMVAGLKSVDYETRLAMLDLFPLEYRRLRGDLILTYALVEHSLANRFFTVDPANTGTGHSKKLFKLRAHTFIRQNFFSFRVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYM1</accession>
    <name>A0A074ZYM1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167816.1">
        <property type="nucleotide sequence ID" value="XM_009169552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYM1"/>
    <dbReference type="GeneID" id="20318921"/>
    <dbReference type="KEGG" id="ovi:T265_04739"/>
    <dbReference type="CTD" id="20318921"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8130" checksum="9016C12FEDEF8CF9" modified="2014-10-01" version="1">MNILTRPLDLSWIFINHCTMVNERCEIWLPTQQTWQLPVKGRKPFAAKSFTPTKQLQAIEQESKRLLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYT2</accession>
    <name>A0A074ZYT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175900.1">
        <property type="nucleotide sequence ID" value="XM_009177636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYT2"/>
    <dbReference type="GeneID" id="20329500"/>
    <dbReference type="KEGG" id="ovi:T265_15335"/>
    <dbReference type="CTD" id="20329500"/>
    <dbReference type="OrthoDB" id="6285229at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="240" mass="27383" checksum="ABB6734275FCF8FF" modified="2014-10-01" version="1" fragment="single">HASNIDDSPQQLEPSEDEALDLRVLKSSPEPGKTEPVEAPDDSIRQLRRGRYIRNRSQYSPTQLTTRRRYERRAMRVSTLRESNSDGEGRTSTETDSIPASGIDAGLPNFNRRTRKYTQSRLPSTPTDPPVRSSHVRKQLCSTCNLEFESSVNFVKHIQRVHVGVNPDKDPRPLLDLQPKPIWNLSDWGHCENAEMLDTSYPYVEKRGQFQEDDWIGSFPGVYSEHSMSINPLNSGNLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYY9</accession>
    <name>A0A074ZYY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167733.1">
        <property type="nucleotide sequence ID" value="XM_009169469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYY9"/>
    <dbReference type="GeneID" id="20318860"/>
    <dbReference type="KEGG" id="ovi:T265_04678"/>
    <dbReference type="CTD" id="20318860"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13377" checksum="A471EC41FFFDA28A" modified="2014-10-01" version="1">MTVGWPLKTWSRTTFSSNAQLKVTCCFKHLGASPSKIMTYPWETRFTGALKPRHTRMQYGSPNSVSRWVDRTARQAFQGLTNLWGSGSFDEPRGATSIVIKCLDNHEEESRAKKEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZC3</accession>
    <name>A0A074ZZC3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HEAT repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164904.1">
        <property type="nucleotide sequence ID" value="XM_009166640.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZZC3"/>
    <dbReference type="GeneID" id="20316595"/>
    <dbReference type="KEGG" id="ovi:T265_02407"/>
    <dbReference type="CTD" id="20316595"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="2">
        <location>
            <begin position="178"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="1">
        <location>
            <begin position="589"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1410" mass="156613" checksum="4B868700702502E1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZK9</accession>
    <name>A0A074ZZK9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_12984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164862.1">
        <property type="nucleotide sequence ID" value="XM_009166598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZK9"/>
    <dbReference type="SMR" id="A0A074ZZK9"/>
    <dbReference type="STRING" id="6198.A0A074ZZK9"/>
    <dbReference type="GeneID" id="20327152"/>
    <dbReference type="KEGG" id="ovi:T265_12984"/>
    <dbReference type="CTD" id="20327152"/>
    <dbReference type="OrthoDB" id="35878at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073:SF5">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="359"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="583" mass="67370" checksum="B4CE61570496F9CF" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0S9</accession>
    <name>A0A075A0S9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_12641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0S9"/>
    <dbReference type="STRING" id="6198.A0A075A0S9"/>
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    <dbReference type="KEGG" id="ovi:T265_12641"/>
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    <dbReference type="OrthoDB" id="6255447at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
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            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER33318.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="691" mass="75840" checksum="71B265F54CCD0489" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="KER33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="17718" checksum="E266EB0ADEC5CF0F" modified="2014-10-01" version="1">MYCNVCCPGALSDDLLAELGGELANISSPIELKPSVRAVMLPRLVMRHLQAKCEARRIDQRSPDQPRTADDAMRCLFVKRRLNLQSVSPAFWMGTENKNTVDIDLASISYSVSNQVRVMVTENSTLFGKRWFGPTNAAFDAGHILRRKSPLHKRVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1H5</accession>
    <name>A0A075A1H5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20318164"/>
    <dbReference type="KEGG" id="ovi:T265_03978"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9508" checksum="680B57B2C87FFF3D" modified="2014-10-01" version="1">MPTEGSTRADIMPWYPSLDKKGREAEVGFEPRTFQSVNSSHLAPYLSSEVPVMTINILLSADSKPSAEGSVRAATKTSFSCSILSMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I4</accession>
    <name>A0A075A1I4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009168608.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075A1I4"/>
    <dbReference type="GeneID" id="20327541"/>
    <dbReference type="KEGG" id="ovi:T265_13374"/>
    <dbReference type="CTD" id="20327541"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="387"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER29420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131749" checksum="B6F5EB59FBC10174" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Z6</accession>
    <name>A0A075A1Z6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596968">
        <property type="protein sequence ID" value="KER21429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174828.1">
        <property type="nucleotide sequence ID" value="XM_009176564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Z6"/>
    <dbReference type="STRING" id="6198.A0A075A1Z6"/>
    <dbReference type="GeneID" id="20324415"/>
    <dbReference type="KEGG" id="ovi:T265_10247"/>
    <dbReference type="CTD" id="20324415"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9610" checksum="31FFED7938608774" modified="2014-10-01" version="1">MDRDRVGISKQELVSMLEEEELRSAVLVVLANKQDIPGCMSISEVANALGLATIKNRRYQIFRTSALKGEGLNEAMDWLTNTLTGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2I6</accession>
    <name>A0A075A2I6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaK family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162766.1">
        <property type="nucleotide sequence ID" value="XM_009164502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2I6"/>
    <dbReference type="STRING" id="6198.A0A075A2I6"/>
    <dbReference type="GeneID" id="20314862"/>
    <dbReference type="KEGG" id="ovi:T265_00674"/>
    <dbReference type="CTD" id="20314862"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11732">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSP105-110-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61773" checksum="16295AAD626C027D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2J9</accession>
    <name>A0A075A2J9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal cation transporter, ZIP family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_01526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163831.1">
        <property type="nucleotide sequence ID" value="XM_009165567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2J9"/>
    <dbReference type="STRING" id="6198.A0A075A2J9"/>
    <dbReference type="GeneID" id="20315714"/>
    <dbReference type="KEGG" id="ovi:T265_01526"/>
    <dbReference type="CTD" id="20315714"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER32477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36373" checksum="0AF49C6F533AB010" modified="2014-10-01" version="1">MELYIDVEEAIEEAKTQLSITSEFPFAPFITLIGFFLVLSIEQIVLAVRSAKQHISHHLHKRPSTPDMSPLDTPLSPQNPGDSTTTPVKFLFNGDATHVSRTTSAPNHLSGETPRRFSSSRYTGPSARYSPNAVSTRPHTHHSHLPDPQTFDSFGSVLRVILLLCAMSVHSLFEGLAVGLQSTVQHTIALFSAILLHKLIIAAGIGVNLATAVTGRPGTQGQSEVSDEEANVNSDNGVKLTRRTLCYQTVATLILSSSSPIGVLIGLGLMQQQQSGVLLMTTATLQGLACGTFFFVVFCELLPQEFREGVGDRIGKLLFLVIGFLLVALYSLLMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A353</accession>
    <name>A0A075A353_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166253.1">
        <property type="nucleotide sequence ID" value="XM_009167989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A353"/>
    <dbReference type="STRING" id="6198.A0A075A353"/>
    <dbReference type="GeneID" id="20317676"/>
    <dbReference type="KEGG" id="ovi:T265_03489"/>
    <dbReference type="CTD" id="20317676"/>
    <dbReference type="OrthoDB" id="415597at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052614">
        <property type="entry name" value="CFAP65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42220" checksum="F0AD11608DFE0A8B" modified="2014-10-01" version="1">MIQRVLFLENRSEEETPYQLICGSNKITNSGYQTRITTVFPLLNGSASSSVGPRSKVRIVIGFSPSSAGHFYRRLTLLSPNTEPQFLSLFGTCHDVEEQPHPLSTLHLKNIVSGLFADNPLQVSRHPQQSNAFEEYTSLRHAEDTVLHMPPISVDPAYIDFTPTDALITKAVKCVFHHKEVVQLGLDVTDNKFGLKRSLVVQNHTSQAMHFKWTPQRILRLADDTDSFNDICASPFHEEFSIEPSEAELPGQGSCQFTITFQPTRLGQFFFHEFEGFASFRAFRDCSLTDSDCVVPPICVIVHCFGNTFQKNEEPFLPNFTLDKGRIKLPRVDSWGVIFDTISLRNNSDLPLLLEQTSTALDPEKADQGLNGSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3E9</accession>
    <name>A0A075A3E9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163509.1">
        <property type="nucleotide sequence ID" value="XM_009165245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3E9"/>
    <dbReference type="GeneID" id="20315448"/>
    <dbReference type="KEGG" id="ovi:T265_01260"/>
    <dbReference type="CTD" id="20315448"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7923" checksum="A830E69EC158DEAC" modified="2014-10-01" version="1">MDSRLTGIDTDEEKHFTPKVQSTHAKHVMFDSRKAEKRSTKFLVAKRDVCVLRKHDKRNENQQQRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4L1</accession>
    <name>A0A075A4L1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sec1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162076.1">
        <property type="nucleotide sequence ID" value="XM_009163812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4L1"/>
    <dbReference type="STRING" id="6198.A0A075A4L1"/>
    <dbReference type="GeneID" id="20314343"/>
    <dbReference type="KEGG" id="ovi:T265_00155"/>
    <dbReference type="CTD" id="20314343"/>
    <dbReference type="OrthoDB" id="6228668at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="74154" checksum="CE48F863670DC4C5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4Q9</accession>
    <name>A0A075A4Q9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596659">
        <property type="protein sequence ID" value="KER30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165728.1">
        <property type="nucleotide sequence ID" value="XM_009167464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4Q9"/>
    <dbReference type="STRING" id="6198.A0A075A4Q9"/>
    <dbReference type="GeneID" id="20327325"/>
    <dbReference type="KEGG" id="ovi:T265_13157"/>
    <dbReference type="CTD" id="20327325"/>
    <dbReference type="OrthoDB" id="10586580at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="139" mass="16219" checksum="D3124D3E885228CF" modified="2014-10-01" version="1" fragment="single">MCTSLTLFGKVENFRYTKQQLSKKTMREHLSCQNNGRHTNLVKNSITLRKSFQAIYELCRRLLKKRRCLVAAETVTISWDFRNISSLKRMSQRPFGFGNRWMDTYSCERAAPRTPGPGEKRYHHPVIPIQSAAVPHYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4T8</accession>
    <name>A0A075A4T8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596899">
        <property type="protein sequence ID" value="KER22434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173824.1">
        <property type="nucleotide sequence ID" value="XM_009175560.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A4T8"/>
    <dbReference type="GeneID" id="20323649"/>
    <dbReference type="KEGG" id="ovi:T265_09480"/>
    <dbReference type="CTD" id="20323649"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704497" evidence="2">
        <location>
            <begin position="19"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="6">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="4">
        <location>
            <begin position="234"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 fourth Ig-like" evidence="7">
        <location>
            <begin position="389"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="3">
        <location>
            <begin position="748"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2449" mass="266280" checksum="C469B06A9BECAC71" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5H0</accession>
    <name>A0A075A5H0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165375.1">
        <property type="nucleotide sequence ID" value="XM_009167111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5H0"/>
    <dbReference type="STRING" id="6198.A0A075A5H0"/>
    <dbReference type="GeneID" id="20316974"/>
    <dbReference type="KEGG" id="ovi:T265_02786"/>
    <dbReference type="CTD" id="20316974"/>
    <dbReference type="OrthoDB" id="6261290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="48427" checksum="80C9023CBA5876A6" modified="2014-10-01" version="1">MDVPVSKSALCHLAPLESSEEMILTLKPTDGRRLVGRGRKREGSTSTNLILEAVTKAVAGLGSHCSDIEERIEEKIRIEEQCVKAVLTRTNAEELEPDVVLEAKQQGPPSRGPRGAPTTGKILERLLISHRLWRIVPFNFEIYPGIRMNVPQDKLNWKVPYPAYRTFRITEDRLSVPYVGMDDGADVSPQTLPYNDYDSQHGVSRKATRGRVRVFRKSNSAETSQLIGLPLNPSGRSGLQGKGLLPHWGPNHAVTVALTRAHPDGIIWNNLPVIQVAVLCRNQNFCLPWYLIDHRADCEFHECTPNVIRALFTRRVYNMIPDKDEAKAILTSLKAANISLVSTGFLHDHLNADHAWIETVFLNIQENSQNAFRPELLKVFVENDASEQVIWLDVCHQIGMRSSHDELLRRLALHCKAYFNEEPGQEEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5I2</accession>
    <name>A0A075A5I2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596887">
        <property type="protein sequence ID" value="KER22649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173603.1">
        <property type="nucleotide sequence ID" value="XM_009175339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5I2"/>
    <dbReference type="GeneID" id="20323483"/>
    <dbReference type="KEGG" id="ovi:T265_09310"/>
    <dbReference type="CTD" id="20323483"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8324" checksum="7CDF74B5884FB1F5" modified="2014-10-01" version="1">MDKSIKEEVDAMFNELDTDRNGKISLDELKAKLEEMHGGSVSRAAVEEFMKVHDADGDKTWSKTELAAFLKAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5P4</accession>
    <name>A0A075A5P4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162581.1">
        <property type="nucleotide sequence ID" value="XM_009164317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5P4"/>
    <dbReference type="GeneID" id="20314701"/>
    <dbReference type="KEGG" id="ovi:T265_00513"/>
    <dbReference type="CTD" id="20314701"/>
    <dbReference type="OrthoDB" id="10450004at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10873" checksum="308472054AE5192E" modified="2014-10-01" version="1">MCCTRPPHASATAIFEISRYMYICNALLIRLLKIRRQPMTGFAFLSRAHQVVPSAGEKRLTEGNTITIFRTSECESKSYSGPTLFKRDFLTLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A753</accession>
    <name>A0A075A753_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_12438</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162118.1">
        <property type="nucleotide sequence ID" value="XM_009163854.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A753"/>
    <dbReference type="GeneID" id="20326606"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="281"/>
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        </location>
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        <location>
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            <end position="365"/>
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        <location>
            <begin position="627"/>
            <end position="889"/>
        </location>
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        <location>
            <begin position="763"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
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            <end position="778"/>
        </location>
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        <location>
            <position position="889"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="889" mass="102624" checksum="F91EDD5D234DC11C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A755</accession>
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        <submittedName>
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        <name evidence="1" type="ORF">T265_08804</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KER23269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17600" checksum="709C8079A3C81DE2" modified="2014-10-01" version="1">MGVLSKNGALYHAAQSISRQGTKDSRSNAFRFADYMNNICTVDGFYRFYVEVEQEHQVRWQSLVTQVHQKLATQKLPMPAVHEHNLWGKQAVEYRKETLSELVQVPALLCISTKLTVSTTVRVQVHRGKKNEPLMNPGKSKEKCKETCDNWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA49</accession>
    <name>A0A075AA49_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20315510"/>
    <dbReference type="KEGG" id="ovi:T265_01322"/>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="160" mass="18205" checksum="E7415A0A6315E07B" modified="2014-10-01" version="1">MVEDMTHPYLRFLTSVLWDIATANDDEELGSPTHKVAENSSAAHDRFRPSASSSSGRWSPRVSVNLMFYLNPNRTVFEKYTHLQPCALAEPTKHGLATYNQWSGPESVHDRNTAIGCTDRANSIESLVYDVLQLNVLHTGRLMIQLARYSRYRTFSRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAV7</accession>
    <name>A0A075AAV7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163250.1">
        <property type="nucleotide sequence ID" value="XM_009164986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAV7"/>
    <dbReference type="GeneID" id="20315231"/>
    <dbReference type="KEGG" id="ovi:T265_01043"/>
    <dbReference type="CTD" id="20315231"/>
    <dbReference type="OrthoDB" id="6245547at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="350" mass="38993" checksum="4F6823D04EBFAA14" modified="2014-10-01" version="1">MNQSDRTPCVRNILIGNVLGTIGILNLIIGLMGISIWTVYLLSKNNSRKSPQGQTARLINGAAETATEDTEEHVKTGWPTCALRPSSKLFLLCIFMSDLLGLCTSNFRFTVLCLVGKDVRLMCGEWCCRVQLVLAYNAGDLSAWFAAIVCAERFLIMLLPTSTYTRNFSRIFPALIISVSMALLTFLTNLFLLIPSEPVCNGSYTNFSIIVFKMIYASVLPFVIVSVSTTGSTVILLRHWHGTRKKNQNRKSKMVTKGMMASQLMLVTGIIFLAGTLPVFVNNLVNPYCCILTAPTNCTLADYRFNAICLAYWTTVCLRTYLLIMISGQTRQDIKQLISQICSHVIQRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABD0</accession>
    <name>A0A075ABD0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171311.1">
        <property type="nucleotide sequence ID" value="XM_009173047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABD0"/>
    <dbReference type="GeneID" id="20321689"/>
    <dbReference type="KEGG" id="ovi:T265_07510"/>
    <dbReference type="CTD" id="20321689"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="130" mass="15472" checksum="3A9E63BBCB2D9B71" modified="2014-10-01" version="1">MSGRSHYASYKGGPVNRGDPDDKYMSELERTSLFPRFVQERLLTDLCKSEWRTWQKCLREHQKSWFAASKCKGIFDLVNQCQNKFVLDPDEVQKLEQEYLEIRSEYRRTGVGRPIMNSQRIREFMRGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACX6</accession>
    <name>A0A075ACX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170583.1">
        <property type="nucleotide sequence ID" value="XM_009172319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACX6"/>
    <dbReference type="STRING" id="6198.A0A075ACX6"/>
    <dbReference type="GeneID" id="20321100"/>
    <dbReference type="KEGG" id="ovi:T265_06921"/>
    <dbReference type="CTD" id="20321100"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="161" mass="18199" checksum="A7C46D0366132D97" modified="2014-10-01" version="1">MARSAFLRTSNQPQFQTLLRRNARPDFVYRRPSGESDRRTRLSNRSQLSTIERSNEQKSPAGCLWNENRNAQVLPTDSVRARPTFSFVKSEQSLKQEQVMDASHPLSGIIAAAQLGFSDADVYTPLNGPLSRQELKIYQSKDPFPAGFIPLLPPPKEMCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE14</accession>
    <name>A0A075AE14_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_13991</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169812.1">
        <property type="nucleotide sequence ID" value="XM_009171548.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AE14"/>
    <dbReference type="GeneID" id="20328158"/>
    <dbReference type="KEGG" id="ovi:T265_13991"/>
    <dbReference type="CTD" id="20328158"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="57"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="219"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="487"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="586"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="672"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="731"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1106"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KER26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1203" mass="137216" checksum="90804111254866F2" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEN5</accession>
    <name>A0A075AEN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169366.1">
        <property type="nucleotide sequence ID" value="XM_009171102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEN5"/>
    <dbReference type="STRING" id="6198.A0A075AEN5"/>
    <dbReference type="GeneID" id="20320137"/>
    <dbReference type="KEGG" id="ovi:T265_05955"/>
    <dbReference type="CTD" id="20320137"/>
    <dbReference type="OrthoDB" id="10062030at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052160">
        <property type="entry name" value="Gypsy_RT_Integrase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47266">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="364" mass="40517" checksum="9325964E4D3C40E6" modified="2014-10-01" version="1">MCNTPQWDDICVFLTSSWTFPNVMSTSYKHTSRKFSTVHDRFRPSWGSSDRHSPRVSINVMFYWKHHKREIQLGSRSNISLCPTKPSQLQSSPAAYTDLHNFVANNALIMSQRNICNKIAKLAAAAAAFAAASAFAMVSEWSSALSVVGSSTLSTVSLGGGESPQREARFLVVHESGCSALYFGSGAGGTKLKVDSHIAVQTFVLRKYNRYRPRVGSNDAQDLLFLKNIDALYSTTSTHSHPSIRATAKLVSQRYVWPNMQKEIRTWAKQCLDCQKSKIHRHTISPTGIFQLPNSRFRNVHIDLVGPLPPSRGHTHILTCVDRFTRWPMAIPINDTSAENVAPLTTSAENVARAVNHYKVNAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHA3</accession>
    <name>A0A075AHA3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166681.1">
        <property type="nucleotide sequence ID" value="XM_009168417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHA3"/>
    <dbReference type="GeneID" id="20318023"/>
    <dbReference type="KEGG" id="ovi:T265_03836"/>
    <dbReference type="CTD" id="20318023"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17850" checksum="C76101E250E02FF0" modified="2014-10-01" version="1">MARGYLTHLSEDRPTILYSRESHHTWRYHKLTGPHTSGQPATARSFIVLTPAETTRPSMSGLCSPAFSSTTLRPTERHGAIKSICQSSSQYFYLKQLPRRINQNDRLLTSEDLMYVASFDVYTQRQIGKQRYPCLALRLNSRLNDIQSDPNCAEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHC2</accession>
    <name>A0A075AHC2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166662.1">
        <property type="nucleotide sequence ID" value="XM_009168398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHC2"/>
    <dbReference type="GeneID" id="20318014"/>
    <dbReference type="KEGG" id="ovi:T265_03827"/>
    <dbReference type="CTD" id="20318014"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705484" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13888" checksum="BA92429CADCE3130" modified="2014-10-01" version="1">MVFMFIAFNWLSYYADSASNLPPKTDVVPYGLILLHKHSVAHQSRLPCHDRFFVPNLSLASGGKRLLKSTSFTVSRIRFREFRCDRVTMLCTPPSHELTNNLMGVPYAAPYPTATNQRNEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHN5</accession>
    <name>A0A075AHN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="5">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_13226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="5"/>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166096.1">
        <property type="nucleotide sequence ID" value="XM_009167832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHN5"/>
    <dbReference type="STRING" id="6198.A0A075AHN5"/>
    <dbReference type="MEROPS" id="M38.980"/>
    <dbReference type="GeneID" id="20327393"/>
    <dbReference type="KEGG" id="ovi:T265_13226"/>
    <dbReference type="CTD" id="20327393"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER30194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="232" mass="25415" checksum="115B14FAA07ACB5C" modified="2014-10-01" version="1" fragment="single">MCDSVLLRTAGVPEPLKCTKFKKSLINPIVMYLACTTLGMTPEEALAGATINAAYSLNMSDRVGAITVGRQADIVVLNCDSSPALEKMFMWLATSSVDEIGGGFMEKLHCGMPHECSACFLIRKILSVVKHFGPFSTVITCLTDTFCTRLRTPKVVCVSCFYLVPLNEFILKCLRILSLKIVSVSGGILCTPCGFCFRWENIIYQFGEAESLITHVIKKGKLIFSQETGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHR1</accession>
    <name>A0A075AHR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase delta small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165984.1">
        <property type="nucleotide sequence ID" value="XM_009167720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHR1"/>
    <dbReference type="STRING" id="6198.A0A075AHR1"/>
    <dbReference type="GeneID" id="20327370"/>
    <dbReference type="KEGG" id="ovi:T265_13203"/>
    <dbReference type="CTD" id="20327370"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="212"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="56985" checksum="153A87CEDBCC7F2E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUE8</accession>
    <name>A0A074YUE8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603212">
        <property type="protein sequence ID" value="KER18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177920.1">
        <property type="nucleotide sequence ID" value="XM_009179656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUE8"/>
    <dbReference type="GeneID" id="20330297"/>
    <dbReference type="KEGG" id="ovi:T265_16132"/>
    <dbReference type="CTD" id="20330297"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11289" checksum="31262DF37F6B281E" modified="2014-10-01" version="1" fragment="single">MLSPLARVYRSTWLTVDDGGRASPCIRFRMVVYRSVGGLPGVQFFRAASWQAFAKTSRCLYTTQSVEERYEALQSLCRQLIMSEPPMPKKLRGLQSPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUQ8</accession>
    <name>A0A074YUQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_16006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600418">
        <property type="protein sequence ID" value="KER18516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177738.1">
        <property type="nucleotide sequence ID" value="XM_009179474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUQ8"/>
    <dbReference type="GeneID" id="20330171"/>
    <dbReference type="KEGG" id="ovi:T265_16006"/>
    <dbReference type="CTD" id="20330171"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="2">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER18516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8057" checksum="D0E874D91BB131DF" modified="2014-10-01" version="1" fragment="single">MSVVPNYGMNKSMGSWDHPFDKEQTQESDFHCLNGESRKVQMMYRKSPFYLADLAELDCMATQFPFRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWE3</accession>
    <name>A0A074YWE3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TBC domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597390">
        <property type="protein sequence ID" value="KER19003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177251.1">
        <property type="nucleotide sequence ID" value="XM_009178987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWE3"/>
    <dbReference type="GeneID" id="20326228"/>
    <dbReference type="KEGG" id="ovi:T265_12060"/>
    <dbReference type="CTD" id="20326228"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="580"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER19003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120869" checksum="A71A89B1317CEB00" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYB3</accession>
    <name>A0A074YYB3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_16249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL607943">
        <property type="protein sequence ID" value="KER18167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178086.1">
        <property type="nucleotide sequence ID" value="XM_009179822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYB3"/>
    <dbReference type="STRING" id="6198.A0A074YYB3"/>
    <dbReference type="GeneID" id="20330414"/>
    <dbReference type="KEGG" id="ovi:T265_16249"/>
    <dbReference type="CTD" id="20330414"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER18167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20468" checksum="9C2D47C55D17213D" modified="2014-10-01" version="1" fragment="single">MKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMGTASASSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYANTVLSGGSTMYPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYC9</accession>
    <name>A0A074YYC9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
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                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <position position="143"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15475" checksum="3449621EF1ADFD1C" modified="2014-10-01" version="1" fragment="single">RAFRELLGYLVCFNVETQTALQRAIAPILRRLLRFVGGASVLWTLRSPTSGLPTPILMHQTSTTSVEGWNVNTPPMPDGRPAEKVDVLFRLDSKETDRSVMGAGVLPPPAANLRDRANLALATLVELAKGQNGALAIGRDVEC</sequence>
</entry>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_hrmn_rcpt"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        </location>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="141434" checksum="1C080FDC8579B5FD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZZ4</accession>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12284" checksum="EF4459F68F5F3274" modified="2014-10-01" version="1">MIGLNSTTRTHLPINLVFTGDSSESLVYDILQQNGLHAGHLMLQLARHSRYRGPFFGSLASKRTHTSSCSLKIGVCHIGVYAASCRRVNEIRWFVCELQSLDPQSFRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="208" mass="23617" checksum="9CD071A57EECA3F6" modified="2014-10-01" version="1">MTSEFTTDASLPYNHDLFESHIVRKTINVDGEVPTSRDTHSGNLDRVWQQDRHRHRLAVRSYSFSNQALRQLLDSRMYLVNNKATQEETTRRYLICAQKGLGSPSTEAQLEGDSAECQLQKSRLDLIFMHYSPPIASLHVLKIMKTKILRYLLPKSFSYSTLLMPKSHTTTRKHGGWDTSGSPKPTQGNSRGRGRVRTKDPTVSNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0E9</accession>
    <name>A0A074Z0E9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597060">
        <property type="protein sequence ID" value="KER20408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175839.1">
        <property type="nucleotide sequence ID" value="XM_009177575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0E9"/>
    <dbReference type="GeneID" id="20325200"/>
    <dbReference type="KEGG" id="ovi:T265_11032"/>
    <dbReference type="CTD" id="20325200"/>
    <dbReference type="OrthoDB" id="6270853at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057376">
        <property type="entry name" value="PH_trem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25356">
        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="395" mass="44853" checksum="A43ED0C22E024CE1" modified="2014-10-01" version="1">MPYGRSLSRGRKGSSYPTGEGMLVDAITKQLLLSEIDAKKMGRTILRGNELFTEGTASAILEGHLRKKKSSGTLNFLVDRIRYKRRTGNTRGECTLYREIKHFYRFPSQPNAFMLCVEQEHTGKRSYETYTCRDASDVNSAQRLVSQARSDPQCLLHNPEQNGRGESTPESDGSYSRYNGRGYVNGVTKTVFSSYETPLITQRQSRWDIMQPVVQSPLLIERTRSASSLQIYDPGSSPEIPNNVSYIQRVVPVRTEPSASTFSHTLVEEVRSPSPIVPMPVHAEHHDWIIQLPSGEYREVKLINPPPRTKFIRPSWNDDVTFISKTNSGREPQVSDTGPVYMYVARTQRPSVTPPQAPEPKLRKKKTSRYDRGSLDYWIHSLPPSKLLSRRTTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0P8</accession>
    <name>A0A074Z0P8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597046">
        <property type="protein sequence ID" value="KER20533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175716.1">
        <property type="nucleotide sequence ID" value="XM_009177452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0P8"/>
    <dbReference type="STRING" id="6198.A0A074Z0P8"/>
    <dbReference type="GeneID" id="20325104"/>
    <dbReference type="KEGG" id="ovi:T265_10936"/>
    <dbReference type="CTD" id="20325104"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="536"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="814"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123701" checksum="613F11CE51419316" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z231</accession>
    <name>A0A074Z231_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597179">
        <property type="protein sequence ID" value="KER19552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176698.1">
        <property type="nucleotide sequence ID" value="XM_009178434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z231"/>
    <dbReference type="GeneID" id="20329670"/>
    <dbReference type="KEGG" id="ovi:T265_15505"/>
    <dbReference type="CTD" id="20329670"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23133" checksum="5A9F0D80B86CC3EF" modified="2014-10-01" version="1" fragment="single">IVESTRVHSTPNSPNSARSLTSFHPLFPPRFLRAVTMKSDQPRLQLRVLNEQNLIIDSLLVGDLIRLEVVSVDYKFSCRLISCITVSQLLLGCMVLLFLDLIVFFLLVWSYRHKLIWRLRPTPKSELQPSGDSRIIPEMSMSSTPQNDLFDSCLIGQPLIGVSGHRSTEGTDMESVRSHLNVCEFYPNSPALTPQSLVVGRAVISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z344</accession>
    <name>A0A074Z344_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596968">
        <property type="protein sequence ID" value="KER21423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174822.1">
        <property type="nucleotide sequence ID" value="XM_009176558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z344"/>
    <dbReference type="GeneID" id="20324409"/>
    <dbReference type="KEGG" id="ovi:T265_10241"/>
    <dbReference type="CTD" id="20324409"/>
    <dbReference type="OrthoDB" id="6269878at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="626"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="641" mass="71877" checksum="1FD29CF7A440D588" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3Z3</accession>
    <name>A0A074Z3Z3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_10005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3Z3"/>
    <dbReference type="GeneID" id="20324173"/>
    <dbReference type="KEGG" id="ovi:T265_10005"/>
    <dbReference type="CTD" id="20324173"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11677" checksum="60608C7FCC406420" modified="2014-10-01" version="1">MQMHLVCAPERRVYRFVKPENTAAHVFVLKNARAYETVCDCVESLCIKRQGNICGQYGPGGLKMFPGTEGRSTEQKRISIETCVVKCSIVAMVFGGTVEPCTATND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z430</accession>
    <name>A0A074Z430_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z430"/>
    <dbReference type="STRING" id="6198.A0A074Z430"/>
    <dbReference type="GeneID" id="20329174"/>
    <dbReference type="KEGG" id="ovi:T265_15008"/>
    <dbReference type="CTD" id="20329174"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21911">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="725"/>
        </location>
    </feature>
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            <end position="228"/>
        </location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="674"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="796" mass="89689" checksum="32D8E076100C5C7D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4D1</accession>
    <name>A0A074Z4D1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER21951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4D1"/>
    <dbReference type="STRING" id="6198.A0A074Z4D1"/>
    <dbReference type="GeneID" id="20329142"/>
    <dbReference type="KEGG" id="ovi:T265_14976"/>
    <dbReference type="CTD" id="20329142"/>
    <dbReference type="OrthoDB" id="6243270at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="523" mass="57301" checksum="4066F0018DFEB225" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4F9</accession>
    <name>A0A074Z4F9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074Z4F9"/>
    <dbReference type="GeneID" id="20324017"/>
    <dbReference type="KEGG" id="ovi:T265_09849"/>
    <dbReference type="CTD" id="20324017"/>
    <dbReference type="OrthoDB" id="6263895at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="28318" checksum="1DE7E07FC0A7F065" modified="2014-10-01" version="1">MEPYENKTRYADVLQKYGLYKYLRTNWVSKEDSTESQLVYRVAFRLNVLCKCPGNDSIRTLFEFTPKKCKVMLVDMQSLNTPLTIQRETLEVVERFMYLGSRISSDCSVTDKVNARICKARAAFGNLRRQNGLFLNLKGRVYQTTVWVVFLYGCETLLIRAAELRRLQVFDNRCLRTIPHMAVDLFAELGNWLANVSSPYEETSSVRISTLPTGNEFDGARKSLKRQEVKSLRKDRKPWVDIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7A8</accession>
    <name>A0A074Z7A8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596866">
        <property type="protein sequence ID" value="KER23071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173181.1">
        <property type="nucleotide sequence ID" value="XM_009174917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7A8"/>
    <dbReference type="STRING" id="6198.A0A074Z7A8"/>
    <dbReference type="GeneID" id="20323149"/>
    <dbReference type="KEGG" id="ovi:T265_08970"/>
    <dbReference type="CTD" id="20323149"/>
    <dbReference type="OrthoDB" id="10335832at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9154" checksum="1BD01DCD711727F3" modified="2014-10-01" version="1">MKEIMKCLGAVGDTRLPGWGPRDPHCAWLETLQNMAANRCQWRSCCQFLSRLPEQLFGFAHLIKTASRLDFGMSLKVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7X3</accession>
    <name>A0A074Z7X3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.</text>
    </comment>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173064.1">
        <property type="nucleotide sequence ID" value="XM_009174800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7X3"/>
    <dbReference type="STRING" id="6198.A0A074Z7X3"/>
    <dbReference type="GeneID" id="20323057"/>
    <dbReference type="KEGG" id="ovi:T265_08878"/>
    <dbReference type="CTD" id="20323057"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15388" checksum="2D0A970053205D7D" modified="2014-10-01" version="1">MEVDYESARLLTNLEVLQLINSRLESKKKIRSQQTLLYTCSKYLKTRTPCAAQSADSVRSFTKAVKSFKFTKLELLMLINHCPSTQVELSVLLSDMDSRFSPDQIEQLLKIIGEHFPESVAASWGLEHVWRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8E1</accession>
    <name>A0A074Z8E1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_08645</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172775.1">
        <property type="nucleotide sequence ID" value="XM_009174511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8E1"/>
    <dbReference type="STRING" id="6198.A0A074Z8E1"/>
    <dbReference type="GeneID" id="20322824"/>
    <dbReference type="KEGG" id="ovi:T265_08645"/>
    <dbReference type="CTD" id="20322824"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="401"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="623" mass="69855" checksum="F33F20A9043233D8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8R6</accession>
    <name>A0A074Z8R6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596843">
        <property type="protein sequence ID" value="KER23601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172645.1">
        <property type="nucleotide sequence ID" value="XM_009174381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8R6"/>
    <dbReference type="STRING" id="6198.A0A074Z8R6"/>
    <dbReference type="GeneID" id="20322723"/>
    <dbReference type="KEGG" id="ovi:T265_08544"/>
    <dbReference type="CTD" id="20322723"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="8">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="860" mass="95667" checksum="AB23DC46358B6259" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8U0</accession>
    <name>A0A074Z8U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596845">
        <property type="protein sequence ID" value="KER23548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172705.1">
        <property type="nucleotide sequence ID" value="XM_009174441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8U0"/>
    <dbReference type="GeneID" id="20322768"/>
    <dbReference type="KEGG" id="ovi:T265_08589"/>
    <dbReference type="CTD" id="20322768"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9245" checksum="072F98D7184425A0" modified="2014-10-01" version="1">MPQERHCVRHWSKSPTPLAIHIVEAGKTPGSNGFDSNAVPEDRFHPVNSWKNSSVINRDQHDMWNVVNTHVMSELFPSKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z929</accession>
    <name>A0A074Z929_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596842">
        <property type="protein sequence ID" value="KER23628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172632.1">
        <property type="nucleotide sequence ID" value="XM_009174368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z929"/>
    <dbReference type="STRING" id="6198.A0A074Z929"/>
    <dbReference type="GeneID" id="20328766"/>
    <dbReference type="KEGG" id="ovi:T265_14600"/>
    <dbReference type="CTD" id="20328766"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER23628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="279" mass="32841" checksum="3D1EB6BB1471A8FC" modified="2014-10-01" version="1" fragment="single">ERQPLTDKNKTDPGNLGKSLDPVYQSVNPCPHRVCRRNHKFPKHMVDEAEFISCSKKTRWKLPLSFTDISGEYLTNCPVDYSLLRNPFSNKPEELNPEEEEKLWQFLGIVRPTADELPNQSTENPFYTTSVPPLHSKRELKRLRQAERQNKLEKWYNLPKPDVTEEDRDDLEVIRLRRALAVETHVRRSDTKTKYFQHGVVVDDPGSFYDRVPRKQRGRTIVDELLSNAELMKQQRKRYARLQRATAEKRAAMHRQKQQRLKRLKSKTGKKQSTILVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z945</accession>
    <name>A0A074Z945_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596842">
        <property type="protein sequence ID" value="KER23638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172625.1">
        <property type="nucleotide sequence ID" value="XM_009174361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z945"/>
    <dbReference type="STRING" id="6198.A0A074Z945"/>
    <dbReference type="GeneID" id="20322711"/>
    <dbReference type="KEGG" id="ovi:T265_08532"/>
    <dbReference type="CTD" id="20322711"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16746" checksum="AB7143094E3708D0" modified="2014-10-01" version="1">MDPERHKSLMEELTSITTTVEERRKIGHEVLRQLLLSNPNLMKVFRPIQSMTLPQALNSSYLGQLSIKFVDSLLEVVRNYNDQDVLRQTIIQLANIHKNRGITVAHFVAVIPLFTDTLASFLHIEENKESLQEVLTTILPMIGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z994</accession>
    <name>A0A074Z994_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_08390</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="KL596834">
        <property type="protein sequence ID" value="KER23801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172448.1">
        <property type="nucleotide sequence ID" value="XM_009174184.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z994"/>
    <dbReference type="GeneID" id="20322569"/>
    <dbReference type="KEGG" id="ovi:T265_08390"/>
    <dbReference type="CTD" id="20322569"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="833"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="2596"/>
            <end position="2713"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="2719"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="950"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1223"/>
            <end position="1244"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    </evidence>
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</entry>
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                <person name="Lin S.J."/>
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                <person name="Hall R.S."/>
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                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="18449" checksum="CAF40D134B433270" modified="2014-10-01" version="1">MNGNTQGKQDVKRIQLQMILTRPCEYRRSGFVNSELVFYSEKRGFDKPATWYYKERHTPVPITRLLPRFLEQWRSEFQERITCAKQNSSIHQLRQVSVAQVYRADLARKLAEMHSHADDEDCSEVEWKRVKEAMLSSFKTVLFKQSDSTMNRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB82</accession>
    <name>A0A074ZB82_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Channel protein, MIP family</fullName>
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    </protein>
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        <name evidence="12" type="ORF">T265_14436</name>
    </gene>
    <organism evidence="12 13">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171883.1">
        <property type="nucleotide sequence ID" value="XM_009173619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB82"/>
    <dbReference type="STRING" id="6198.A0A074ZB82"/>
    <dbReference type="GeneID" id="20328602"/>
    <dbReference type="KEGG" id="ovi:T265_14436"/>
    <dbReference type="CTD" id="20328602"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023275">
        <property type="entry name" value="Aquaporin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02015">
        <property type="entry name" value="AQUAPORIN3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28953" checksum="780BF44CC535B227" modified="2014-10-01" version="1" fragment="single">MAGSLSSYEYERVSCQSKYESTIHRWADKMRLTRPLLLRVFIGELMGTMILVIFGDAAVAQSVFGSNVSAFSISFGWGSAVIFGIFTSGTMGYGLLNPAVALAFAFNAKVPWIAVPVATIAELIGAFLGGLIVYCNYQVNIQLLDPGLTTKTLGIFCTAPSNAGNLAGFYDQIIGTALLTLMVLAMGDCFNVPTYVFPILVGLLITALVGAFGVNAGAALNPARDLGPRLAAFAVGYKDAFTAYNSYCWVPIVGPYIGAILGVLLYELIIGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCS2</accession>
    <name>A0A074ZCS2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596791">
        <property type="protein sequence ID" value="KER24973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171276.1">
        <property type="nucleotide sequence ID" value="XM_009173012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCS2"/>
    <dbReference type="GeneID" id="20321658"/>
    <dbReference type="KEGG" id="ovi:T265_07479"/>
    <dbReference type="CTD" id="20321658"/>
    <dbReference type="OrthoDB" id="10067479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="101" mass="11337" checksum="4D1E6FA455CB17DE" modified="2014-10-01" version="1">MTKKKPPSGRPVSANPAQGNEDESIYLKLSDIPYDLMRFNISMKKGVDRREARKALLLRMGAAPPKKQFINYKQLMRDKAESKAKAALLPVDVCIVEPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCY5</accession>
    <name>A0A074ZCY5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171233.1">
        <property type="nucleotide sequence ID" value="XM_009172969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCY5"/>
    <dbReference type="GeneID" id="20328458"/>
    <dbReference type="KEGG" id="ovi:T265_14292"/>
    <dbReference type="CTD" id="20328458"/>
    <dbReference type="OrthoDB" id="6125674at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="330" mass="37127" checksum="301AF0813F4B1880" modified="2014-10-01" version="1">MTFVHLSRVANLWTGVLPMLGKFANGDGKRKHISWIPVFLGFVLLAPLPALLVVFATASSYDPEYLRCHLGTDWMAPFVIVPHILSKFSSHRTLAVSYFCLLLLCILLSTSLRLLATIDNILDMFMAADSLRRQRRKVHCTTVLIVVLFLSVLGIPMICRSGFFWMRLVEAYAERLIVVLATIQGVGFLVVYARTEASGYGQKVRLLIVNVVYGLLFSLAAIVYAWYAVIATNTPTDSQCHTYSQAPKDDPLTNNFQYLGWLIAVSPIALGLLYTIATVFKRSQKENRKFCEVICNGDARRNERRYVERPAYCSVAQGDGLHDVTYQWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD51</accession>
    <name>A0A074ZD51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171046.1">
        <property type="nucleotide sequence ID" value="XM_009172782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD51"/>
    <dbReference type="STRING" id="6198.A0A074ZD51"/>
    <dbReference type="GeneID" id="20321474"/>
    <dbReference type="KEGG" id="ovi:T265_07295"/>
    <dbReference type="CTD" id="20321474"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER25191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15166" checksum="12CCE278F2AB0FF6" modified="2014-10-01" version="1">MGRKGARNTRYKVKNRSRDIDQIYEDVKEENIVRRIAEATEPDEDLPALGQFFCVSCNKYFINERTLLVHKTGKPHKRRLKALVEQPHTQDDADFAAGLMKDDSHLRNKKLATSAQDQSAPLFNSLASYACAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDU0</accession>
    <name>A0A074ZDU0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170949.1">
        <property type="nucleotide sequence ID" value="XM_009172685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDU0"/>
    <dbReference type="GeneID" id="20328398"/>
    <dbReference type="KEGG" id="ovi:T265_14232"/>
    <dbReference type="CTD" id="20328398"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="24479" checksum="0F2C869E023D309F" modified="2014-10-01" version="1" fragment="single">MASALNFAPHLTPYNTTRPYTLKINLSGFYSVQHFDFFGESQTLRWNVHHQKIRSVDMEHQISNGEARQTAFGRSKSRSIDELITLHRLCWLGHVLRKPVDRLSRRDHFAQLRKRHGLVGPSVALVHPSYYFQCIAPVPTQPPALNSPLTVLYLRTNLSASAYNAWLLTAPSQLIGERNCGSCNHCTTSRWLLRLMIMMMMMTMGGRRDNHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEQ1</accession>
    <name>A0A074ZEQ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596767">
        <property type="protein sequence ID" value="KER25761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170508.1">
        <property type="nucleotide sequence ID" value="XM_009172244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEQ1"/>
    <dbReference type="GeneID" id="20321041"/>
    <dbReference type="KEGG" id="ovi:T265_06862"/>
    <dbReference type="CTD" id="20321041"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="260" mass="29772" checksum="0AC0E19CA4426B95" modified="2014-10-01" version="1">MAIDVISYLVRCVEICGHPPAWKFDSSLDKTEHVLGKNVTPMLWMRYSVWRSYLVCLGQGLLSEKVDFSGTECETENWQFLQHLSYWVLDGMRTVFCEIEFKCTMLTDDDDDDDSTAVKQHFAAGFQLNYGCTAAKHAVDDIDDDDDDDDDDDDDDDDDDIDDDVDDDFDDYFDHDHDDDHDDDEVDIVDQDSTHTIRMYQRWRHPGGHVELKPVTTAKASWPHAVAIMCRVTEGKILEGRIVAQCCVEDCVGGRAKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF62</accession>
    <name>A0A074ZF62_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein axonemal heavy chain 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">T265_06797</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170426.1">
        <property type="nucleotide sequence ID" value="XM_009172162.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZF62"/>
    <dbReference type="GeneID" id="20320976"/>
    <dbReference type="KEGG" id="ovi:T265_06797"/>
    <dbReference type="CTD" id="20320976"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001112">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="18">
        <location>
            <begin position="476"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="19">
        <location>
            <begin position="1140"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="23">
        <location>
            <begin position="1527"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="26">
        <location>
            <begin position="1891"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="21">
        <location>
            <begin position="2055"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="20">
        <location>
            <begin position="2300"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="22">
        <location>
            <begin position="2674"/>
            <end position="2895"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="17">
        <location>
            <begin position="3138"/>
            <end position="3253"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="24">
        <location>
            <begin position="3289"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="25">
        <location>
            <begin position="3435"/>
            <end position="3738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2527"/>
            <end position="2592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KER25823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3742" mass="429049" checksum="AB644B267F894FB6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFJ7</accession>
    <name>A0A074ZFJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170316.1">
        <property type="nucleotide sequence ID" value="XM_009172052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFJ7"/>
    <dbReference type="STRING" id="6198.A0A074ZFJ7"/>
    <dbReference type="GeneID" id="20328270"/>
    <dbReference type="KEGG" id="ovi:T265_14104"/>
    <dbReference type="CTD" id="20328270"/>
    <dbReference type="OrthoDB" id="6256369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122112" checksum="6C1B54260ABE5C08" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFV5</accession>
    <name>A0A074ZFV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170176.1">
        <property type="nucleotide sequence ID" value="XM_009171912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFV5"/>
    <dbReference type="STRING" id="6198.A0A074ZFV5"/>
    <dbReference type="GeneID" id="20320787"/>
    <dbReference type="KEGG" id="ovi:T265_06608"/>
    <dbReference type="CTD" id="20320787"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="117"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="713" mass="77025" checksum="4519B129D969A57A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG88</accession>
    <name>A0A074ZG88_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169940.1">
        <property type="nucleotide sequence ID" value="XM_009171676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG88"/>
    <dbReference type="GeneID" id="20320597"/>
    <dbReference type="KEGG" id="ovi:T265_06418"/>
    <dbReference type="CTD" id="20320597"/>
    <dbReference type="OrthoDB" id="8063258at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8589" checksum="ABF102F7F1C2E4D1" modified="2014-10-01" version="1">MTRRRSGGGEGWLLFSQIGGPSGLAKDDISICIGKARAVFVKPHHLRYRRDISSSVSYNAAPILLYGSETWPLRAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGJ7</accession>
    <name>A0A074ZGJ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_14018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169921.1">
        <property type="nucleotide sequence ID" value="XM_009171657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGJ7"/>
    <dbReference type="STRING" id="6198.A0A074ZGJ7"/>
    <dbReference type="GeneID" id="20328184"/>
    <dbReference type="KEGG" id="ovi:T265_14018"/>
    <dbReference type="CTD" id="20328184"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER26333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21349" checksum="82D7E20E9776E4FB" modified="2014-10-01" version="1" fragment="single">DKPTTIKEAIKKWEEKTGQKASEAKEVKLYAQYPPIEKLDASLSTLTACEKLSLSTNCIEKITNLNGLKNLKILSLARNNIKNLNGLEVLGDTLEQLWISYNILERLKGIGVLRRLRVLYMSNNLVKEWSEFQKLSELQNLEDLLFLGNPLEENNSETWRDEACRRLPRLKKLDGVPVLHEEADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHS7</accession>
    <name>A0A074ZHS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596878">
        <property type="protein sequence ID" value="KER22825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173436.1">
        <property type="nucleotide sequence ID" value="XM_009175172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHS7"/>
    <dbReference type="STRING" id="6198.A0A074ZHS7"/>
    <dbReference type="GeneID" id="20328941"/>
    <dbReference type="KEGG" id="ovi:T265_14775"/>
    <dbReference type="CTD" id="20328941"/>
    <dbReference type="OrthoDB" id="432311at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16940" checksum="2B5F462B153A3926" modified="2014-10-01" version="1" fragment="single">YPATSPNLTIYEVHGLADRDVRRLTILLNELIAERKGDPVLFDIIDFSREFIANNVPTVNCAICLCGFVQESDVYCTPEFHYFHNTCIGEYMHHREKEHQEELAELLEKDPYCILVPLRLPCPVCRVEELPYSESLVQLAHQKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI20</accession>
    <name>A0A074ZI20_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596735">
        <property type="protein sequence ID" value="KER26953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169329.1">
        <property type="nucleotide sequence ID" value="XM_009171065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI20"/>
    <dbReference type="STRING" id="6198.A0A074ZI20"/>
    <dbReference type="GeneID" id="20320112"/>
    <dbReference type="KEGG" id="ovi:T265_05930"/>
    <dbReference type="CTD" id="20320112"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21888" checksum="C56A70C046A6B7CB" modified="2014-10-01" version="1">MVQADSASSNIYQPLDFSFFDIKEVSDILKCEPRIQPGIHWKCPKTKDGKWITKTLKATNNQIEEMTEIPEIVHELFGSAEWITWLDFSCNKITSIPASIRKLTSLKVIYLHGNQIKCFQDVQRLCDLADLRKLTLHGNPVEREKNYFRIVIAILPNLISLDFTGISKADHEASRPFERSGSRGRKRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ23</accession>
    <name>A0A074ZJ23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA dimethylallyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_05896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596734">
        <property type="protein sequence ID" value="KER26991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169289.1">
        <property type="nucleotide sequence ID" value="XM_009171025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ23"/>
    <dbReference type="STRING" id="6198.A0A074ZJ23"/>
    <dbReference type="GeneID" id="20320078"/>
    <dbReference type="KEGG" id="ovi:T265_05896"/>
    <dbReference type="CTD" id="20320078"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02019">
        <property type="entry name" value="NK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER26991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="94178" checksum="0877C4C564145D10" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ46</accession>
    <name>A0A074ZJ46_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169229.1">
        <property type="nucleotide sequence ID" value="XM_009170965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ46"/>
    <dbReference type="STRING" id="6198.A0A074ZJ46"/>
    <dbReference type="GeneID" id="20320026"/>
    <dbReference type="KEGG" id="ovi:T265_05844"/>
    <dbReference type="CTD" id="20320026"/>
    <dbReference type="OrthoDB" id="6261054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22218" checksum="699310BA24F3753A" modified="2014-10-01" version="1">MYGGMRGIKGLVTETSVLDPNEGIRFRGLSIPECQKRLPRAVKDGEPLPEGIYFLLLTGQVPTKDQVDEISRELANRADLPPHVAKMLDNFPSSLHPMSQFASACAALNSESKFAKAYHEGVKKALYWEKRQILSGYPPNWAYFHMRIEEKVLEEWDTSSINPLPKKGTPESLWDVCGNCDIEDVPVSLFEDLLNADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJA3</accession>
    <name>A0A074ZJA3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_08656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172791.1">
        <property type="nucleotide sequence ID" value="XM_009174527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJA3"/>
    <dbReference type="STRING" id="6198.A0A074ZJA3"/>
    <dbReference type="GeneID" id="20322835"/>
    <dbReference type="KEGG" id="ovi:T265_08656"/>
    <dbReference type="CTD" id="20322835"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="108334" checksum="3F488337C92CC064" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJW2</accession>
    <name>A0A074ZJW2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">ATPase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_08529</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596842">
        <property type="protein sequence ID" value="KER23635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172622.1">
        <property type="nucleotide sequence ID" value="XM_009174358.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZJW2"/>
    <dbReference type="GeneID" id="20322708"/>
    <dbReference type="KEGG" id="ovi:T265_08529"/>
    <dbReference type="CTD" id="20322708"/>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000010">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF19">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="19">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="20">
        <location>
            <begin position="486"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="596"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="871"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1245"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="21">
        <location>
            <begin position="1748"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="22">
        <location>
            <begin position="1895"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="22">
        <location>
            <begin position="2118"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="873"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1100"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1406"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KER23635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2263" mass="259691" checksum="DECE402ADF57C85E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKW9</accession>
    <name>A0A074ZKW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the origin recognition complex (ORC) that binds origins of replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596826">
        <property type="protein sequence ID" value="KER24010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172226.1">
        <property type="nucleotide sequence ID" value="XM_009173962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKW9"/>
    <dbReference type="STRING" id="6198.A0A074ZKW9"/>
    <dbReference type="GeneID" id="20322398"/>
    <dbReference type="KEGG" id="ovi:T265_08219"/>
    <dbReference type="CTD" id="20322398"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007858">
        <property type="entry name" value="ORC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="274"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="488" mass="54959" checksum="47A91804C8FF8CA4" modified="2014-10-01" version="1">MDLIFHALRRRLYRSDHELLLFEDELFRLKQAIKTLVFDGESNSLLIIGRRGVGKKRAITCTSVKGLKKGQQHKRQPSGSPSEWLGSHLFIFTILGLIHTDDGSALRAMARQLHRESLLQSPSSEVPETDRIAGTKSLPFSQQLQWFLDGLHSGDGSSKSLLIVLHEFDLFASHRNQILLYNLFDCCQCNDTPICVIGLTCRLDIMELLEKRVKSRFSHRQIHLISIAAPLDHSSSRAVDNEGSQIAFDNYCLACEHLLQLNLDYVCGTAHNLATGKERRELDACVKSWNSHVRELLFDEIVIDTLRQAWSVSANLRRLTNLLVPIVAKLGGAKTRIDPVEFIDSLCILREDSKLNSLKGLCVLELFLIATLVKLQEIHEGRPVNFELLYAEYAKFCRSNCPGYLYDKPVVHKSLDNLIDLELVVAGKSAMAAAATAAASRGTSGQWAMHPNYKPLFCFVESQLLSACLDAYPNCPMELRFWIHSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLB1</accession>
    <name>A0A074ZLB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168109.1">
        <property type="nucleotide sequence ID" value="XM_009169845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLB1"/>
    <dbReference type="GeneID" id="20319150"/>
    <dbReference type="KEGG" id="ovi:T265_04968"/>
    <dbReference type="CTD" id="20319150"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25291" checksum="E5E351F757B933A9" modified="2014-10-01" version="1">MSPKKDETGRGLSKRFQQPSRSLLRLDWTIVQLCIGPLASCSAHYGISKGTVALHSPFWRQRKTITTVVTVFHKVVPESSVRMCAADPLSHVRSRPVCGASLDLFSHGFHVIARTMRITRPSSKGTTATHATELSFCSPLFGVRTLTLHSVESTESLVYDVLQLNVLHTGRLMIQLARYSRYRRIFSSRKLLTRLMKTLPQPTTGFALRGAHQSMVTNIKRECKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLV5</accession>
    <name>A0A074ZLV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168197.1">
        <property type="nucleotide sequence ID" value="XM_009169933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLV5"/>
    <dbReference type="GeneID" id="20319215"/>
    <dbReference type="KEGG" id="ovi:T265_05033"/>
    <dbReference type="CTD" id="20319215"/>
    <dbReference type="OrthoDB" id="10367652at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="1">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22139" checksum="3CCD0491914C04C2" modified="2014-10-01" version="1">MTLRFAGAKCIPINAATWASSSTITCNFSSSSKHLAPAINMTSVQKNSFYHYPDDQITNLQEQPFGKQPNVVKGFTIEECRNEPCTLKTGQTLTGSMVFEPTHEFPAIVPWVRVTGTLGLNYWIKFPSPYVDGCKFTTPPCPIKSGSFYTIDIQTKVPKRKPEKNHAAQRIAHPSPMTLNVTSVACCPKTEVLQANDGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZML4</accession>
    <name>A0A074ZML4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methionine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_07791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KL596804">
        <property type="protein sequence ID" value="KER24600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171667.1">
        <property type="nucleotide sequence ID" value="XM_009173403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZML4"/>
    <dbReference type="STRING" id="6198.A0A074ZML4"/>
    <dbReference type="GeneID" id="20321970"/>
    <dbReference type="KEGG" id="ovi:T265_07791"/>
    <dbReference type="CTD" id="20321970"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="308"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="14">
        <location>
            <begin position="740"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="828"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER24600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134262" checksum="B03EE4C70702F813" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMT9</accession>
    <name>A0A074ZMT9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167576.1">
        <property type="nucleotide sequence ID" value="XM_009169312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMT9"/>
    <dbReference type="STRING" id="6198.A0A074ZMT9"/>
    <dbReference type="GeneID" id="20318730"/>
    <dbReference type="KEGG" id="ovi:T265_04548"/>
    <dbReference type="CTD" id="20318730"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="628" mass="68267" checksum="ABCD40DD83433B1C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNH1</accession>
    <name>A0A074ZNH1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596794">
        <property type="protein sequence ID" value="KER24885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171381.1">
        <property type="nucleotide sequence ID" value="XM_009173117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNH1"/>
    <dbReference type="GeneID" id="20328487"/>
    <dbReference type="KEGG" id="ovi:T265_14321"/>
    <dbReference type="CTD" id="20328487"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="21628" checksum="C89409915B56E5EB" modified="2014-10-01" version="1">MLNLERENSKIPFYSTVPSTDKEMGQPYLSGQLFIGRLNMNLTEKSRLLLSWFGRPSSISALVLPSGDLAVMQQKDVTSVVEFVEYVLISLSIEQSSCHTVPIILYTSGGGKQWTRVLLLLELNSSVHPIVVPGFELEASDMRGKHVTINTPAHANLTEKSRLLLSWFGRPSSISALVLPSGDLAVMQQKDVTVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNI5</accession>
    <name>A0A074ZNI5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_14313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171355.1">
        <property type="nucleotide sequence ID" value="XM_009173091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNI5"/>
    <dbReference type="STRING" id="6198.A0A074ZNI5"/>
    <dbReference type="GeneID" id="20328479"/>
    <dbReference type="KEGG" id="ovi:T265_14313"/>
    <dbReference type="CTD" id="20328479"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="256"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="362"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER24900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1271" mass="142489" checksum="D4894B2E1DFE932B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP51</accession>
    <name>A0A074ZP51_OPIVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_07397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20321576"/>
    <dbReference type="KEGG" id="ovi:T265_07397"/>
    <dbReference type="CTD" id="20321576"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="250" mass="27294" checksum="62499E7546639A95" modified="2014-10-01" version="1">MPDVYNVIFPTRAKFLLSRLVSVFEFPTTGARWTKWLECEFTYQKVRRSNPTSASRLPLSRLGQPDSIPGLVSPSCGMATRHRKGATAERCFLFPTTQIQSAISVSNHFTNFPPLGQPGSIPALVPTSGGMTARHQKDVTASSIQFFLALTYGFKPILWCIDRQSREHSSDLKGKVVHTSHIIQWQTTTIQSCLAAMLPEGSMRAGILPGCPGLDRGSREAEVGFEPVAVSVPSGLGSGQIKFRPCSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP60</accession>
    <name>A0A074ZP60_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER25120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP60"/>
    <dbReference type="GeneID" id="20321524"/>
    <dbReference type="KEGG" id="ovi:T265_07345"/>
    <dbReference type="CTD" id="20321524"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="252" mass="28248" checksum="44D16C784A930877" modified="2014-10-01" version="1">MKFFQHTQFPYYPVVVFRYTKSQRYTHLQINLLFTGDSIEHLVYDVLQQNVLHTDRLMIQLTRYWRYRRRESTDRKARGSNPTSAFGLPLSRLGQSGSIPALVPPSGRVAVRRRKGVKAKRLFTGQIHTRLTILVRTPGFSLRWPKWLEREFTHQKVRDLNPTSASLLPLSKLGQPGSIPALVQPSGGMAVRHRKGATAERTNFLSQMNANAVIKAISSSVPIMGGLDSIGVDDPVDSIIDSISGDPNTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPA7</accession>
    <name>A0A074ZPA7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167316.1">
        <property type="nucleotide sequence ID" value="XM_009169052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPA7"/>
    <dbReference type="STRING" id="6198.A0A074ZPA7"/>
    <dbReference type="GeneID" id="20318525"/>
    <dbReference type="KEGG" id="ovi:T265_04343"/>
    <dbReference type="CTD" id="20318525"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000085">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="726" mass="81572" checksum="FB98F4DFBD65B14C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQM2</accession>
    <name>A0A074ZQM2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_03904</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166769.1">
        <property type="nucleotide sequence ID" value="XM_009168505.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZQM2"/>
    <dbReference type="GeneID" id="20318091"/>
    <dbReference type="KEGG" id="ovi:T265_03904"/>
    <dbReference type="CTD" id="20318091"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="22">
        <location>
            <begin position="356"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="694"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KER29436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1605" mass="178466" checksum="C232A129BA4CC4BD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR24</accession>
    <name>A0A074ZR24_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167982.1">
        <property type="nucleotide sequence ID" value="XM_009169718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR24"/>
    <dbReference type="STRING" id="6198.A0A074ZR24"/>
    <dbReference type="GeneID" id="20319046"/>
    <dbReference type="KEGG" id="ovi:T265_04864"/>
    <dbReference type="CTD" id="20319046"/>
    <dbReference type="OrthoDB" id="6245065at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127105" checksum="53DFA91092C517D8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRF7</accession>
    <name>A0A074ZRF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocon-associated protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_03487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER30008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166251.1">
        <property type="nucleotide sequence ID" value="XM_009167987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRF7"/>
    <dbReference type="STRING" id="6198.A0A074ZRF7"/>
    <dbReference type="GeneID" id="20317674"/>
    <dbReference type="KEGG" id="ovi:T265_03487"/>
    <dbReference type="CTD" id="20317674"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704288" description="Translocon-associated protein subunit beta" evidence="2">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20399" checksum="32CA273085C2E40B" modified="2014-10-01" version="1">MVFHFLFSCAFIFLTVSGQATDVARLAVSKQVLNEYIFQGKELTILYTIYNLHSSRPARDVELFDSYSDTEFIQIHGSKSARWPHISAGTNVTHAVVFLPQAAGTYNFTSATITYNLGDPSKTILHYSSAPGHVIIYPLKEYNRRFATHTMEWIGFAMLVTPCLLIPYMLWRSSASKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRK7</accession>
    <name>A0A074ZRK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166539.1">
        <property type="nucleotide sequence ID" value="XM_009168275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRK7"/>
    <dbReference type="GeneID" id="20317915"/>
    <dbReference type="KEGG" id="ovi:T265_03728"/>
    <dbReference type="CTD" id="20317915"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="13731" checksum="2934C60E731D80DC" modified="2014-10-01" version="1">MPLDECVKLIEKISSMSGKVSRFPSAKRCFSQIMPAESSKGTVYARHQSKHPSGILKTPASATQTLACEVRDEFVNRSPKVHRNLHVIEPIKKDILMRFLCIRDVDVDISVTLTPNTYSSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS11</accession>
    <name>A0A074ZS11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_06551</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170111.1">
        <property type="nucleotide sequence ID" value="XM_009171847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS11"/>
    <dbReference type="STRING" id="6198.A0A074ZS11"/>
    <dbReference type="GeneID" id="20320730"/>
    <dbReference type="KEGG" id="ovi:T265_06551"/>
    <dbReference type="CTD" id="20320730"/>
    <dbReference type="OrthoDB" id="10035433at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="286"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="886"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1077" mass="124776" checksum="A4AE89EA96F868F1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSA6</accession>
    <name>A0A074ZSA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165951.1">
        <property type="nucleotide sequence ID" value="XM_009167687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSA6"/>
    <dbReference type="GeneID" id="20317441"/>
    <dbReference type="KEGG" id="ovi:T265_03254"/>
    <dbReference type="CTD" id="20317441"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8712" checksum="0DEDEDB6CA79D67F" modified="2014-10-01" version="1">MNFTDFKAAGIKEENRQNRPATAGYTFIQFLDRICEVEALKEKLSPEKCGRGRTSRAHRALVVPSSECSWETSKCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV60</accession>
    <name>A0A074ZV60_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">succinate dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_15668</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5"/>
    <dbReference type="EMBL" id="KL597345">
        <property type="protein sequence ID" value="KER19079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177174.1">
        <property type="nucleotide sequence ID" value="XM_009178910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV60"/>
    <dbReference type="STRING" id="6198.A0A074ZV60"/>
    <dbReference type="GeneID" id="20329833"/>
    <dbReference type="KEGG" id="ovi:T265_15668"/>
    <dbReference type="CTD" id="20329833"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="17">
        <location>
            <begin position="47"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="18">
        <location>
            <begin position="521"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR630664-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER19079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="674" mass="74661" checksum="0343041CACC3AF9F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVF2</accession>
    <name>A0A074ZVF2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597309">
        <property type="protein sequence ID" value="KER19144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177105.1">
        <property type="nucleotide sequence ID" value="XM_009178841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVF2"/>
    <dbReference type="GeneID" id="20326146"/>
    <dbReference type="KEGG" id="ovi:T265_11978"/>
    <dbReference type="CTD" id="20326146"/>
    <dbReference type="OrthoDB" id="6232638at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="28343" checksum="74F06C32C3EB8AEC" modified="2014-10-01" version="1">MHQISNCRLSIGDQGLAPNDCLRLFHKLTNLFLYQSGQFPDFTLMQRPKTAYEYLRSCQGTDAHKVVKFLDSLQELEQHLSELPFPVHYCLILLGGLPSHPKRAFLVDFVGSSPQDTFTDEAVISPSTPNRSEPIFSDFFRSFVQHPFYQLLMEGAPPTRTFFYFYMPTNYESKWFLPRPNFRLFRKCPVYVLQILTDSKHSMILDDLEADRCLLDINKILYGESSDRMWYASPVSVEGFRGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVQ2</accession>
    <name>A0A074ZVQ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="195"/>
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="339" mass="37573" checksum="4DDAAC7E46ED9FE0" modified="2014-10-01" version="1">MPFQGTSGCVPKLRRNVTFRDVSKSVHLALFSGRNYIMGVDITFDALFSYCGVKPVFSVGADIAWPTRRQTSESPSLTSRVATYGSVGAKSNFQPPNMVGCWLNVLLLLGLWQTEAQFLHSIHGILRPAQPAVVRRWTVFTGKRVVLNCSVELPLEINPQQVQYRWERPEGTPIGYSKLYVIPNVSLSDGGLYVCHSSAFLGFSGEQWSQKHRLLLDVSTLTKMHSGVAAEIVLRLVQLIEIHRSPVCRPTAGKTAMPTAEQINSQSCHSSRVHAALGWTGLIGPIEALCTKFKKITPSCQPNNRIYNKAHILFKNPTAIPVNDDFVPTRAKENICTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVW7</accession>
    <name>A0A074ZVW7_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">T265_02239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_02239"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="171"/>
            <end position="187"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="187" mass="20895" checksum="E9396500435D09BC" modified="2014-10-01" version="1">MRLSPADDLWIQRFRRILTALQIGKRNGSMHALKAYLFTNGRRRRPSSGLGKEFGRADLLPIVCNPSLLRCAHCYRAFRSEVAKTHVVHCYNKAVQGDGHVPNALGRIVAAGCSPGLIRSRQLRQARHFVLSNTGLDTYRSMAKYAEMLLQRARAKSSCLNTEMKQCRPESGNQDPKSVANNNTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW09</accession>
    <name>A0A074ZW09_OPIVI</name>
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        <recommendedName>
            <fullName evidence="4">Negative elongation factor B</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">T265_02478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009166727.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZW09"/>
    <dbReference type="GeneID" id="20316666"/>
    <dbReference type="KEGG" id="ovi:T265_02478"/>
    <dbReference type="CTD" id="20316666"/>
    <dbReference type="OrthoDB" id="5548359at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </feature>
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        </location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1208" mass="129962" checksum="0B833AE32F21E09B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWM5</accession>
    <name>A0A074ZWM5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_03250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009167683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWM5"/>
    <dbReference type="GeneID" id="20317437"/>
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    <dbReference type="OrthoDB" id="6267099at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705374" evidence="3">
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            <begin position="23"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="516"/>
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        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="754" mass="85088" checksum="9162EEDAD03F3EF9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWP0</accession>
    <name>A0A074ZWP0_OPIVI</name>
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        <recommendedName>
            <fullName evidence="7">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">T265_03267</name>
    </gene>
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        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165964.1">
        <property type="nucleotide sequence ID" value="XM_009167700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWP0"/>
    <dbReference type="STRING" id="6198.A0A074ZWP0"/>
    <dbReference type="GeneID" id="20317454"/>
    <dbReference type="KEGG" id="ovi:T265_03267"/>
    <dbReference type="CTD" id="20317454"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="232"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="784" mass="87315" checksum="DFE1BA49E3CCB3CB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXA7</accession>
    <name>A0A074ZXA7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_11489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176423.1">
        <property type="nucleotide sequence ID" value="XM_009178159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXA7"/>
    <dbReference type="STRING" id="6198.A0A074ZXA7"/>
    <dbReference type="GeneID" id="20325657"/>
    <dbReference type="KEGG" id="ovi:T265_11489"/>
    <dbReference type="CTD" id="20325657"/>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER19824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="37758" checksum="0A19D417D8F645A4" modified="2014-10-01" version="1">MDLPWIEKYRPQSLDELISHSEISKTISRFLEQNRLPHLLFYGPPGTGKTSTILATAKTLYAPRELNSMVLEVKFSRSFLLLFSKLNASDARGINVVREQLLSFASTKTLFAGKFKLVILDEADSMTKDAQNALRRIVEKFTENTRFCLICNYLSKIIPAIQSRCTKFRFAPVSFQQMQPRLKEIATMEKVVLTEDGMKAIYRFTSGDMRKAINLMQSAAMSAPKIDESSVYACVAYPSPAEIRSLTDSMLNEPIHSAFKNILATKNLKGIALQDVLTELHPLVMKINFPDSVRCDLIIALAELEHRMSVGSSERLQLAALVASFARAKSSLEHVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXP6</accession>
    <name>A0A074ZXP6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Agenet-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597110">
        <property type="protein sequence ID" value="KER19979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176268.1">
        <property type="nucleotide sequence ID" value="XM_009178004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXP6"/>
    <dbReference type="STRING" id="6198.A0A074ZXP6"/>
    <dbReference type="GeneID" id="20329581"/>
    <dbReference type="KEGG" id="ovi:T265_15416"/>
    <dbReference type="CTD" id="20329581"/>
    <dbReference type="OrthoDB" id="424249at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Agenet-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="751" mass="82391" checksum="B1A5730EC8486AFC" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXS6</accession>
    <name>A0A074ZXS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165519.1">
        <property type="nucleotide sequence ID" value="XM_009167255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXS6"/>
    <dbReference type="GeneID" id="20317090"/>
    <dbReference type="KEGG" id="ovi:T265_02902"/>
    <dbReference type="CTD" id="20317090"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="12173" checksum="2BED63BE87CD6A40" modified="2014-10-01" version="1">MFLRPRPVNARTQNRSFVPQRETASLRTLRRGIVRSDRENYFNKKALETERVSQPMHEVEQRKPAVGGQLHVHHRLLRQVGTARLFSSCTRVFLHNKRMILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY07</accession>
    <name>A0A074ZY07_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_13093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165414.1">
        <property type="nucleotide sequence ID" value="XM_009167150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY07"/>
    <dbReference type="STRING" id="6198.A0A074ZY07"/>
    <dbReference type="GeneID" id="20327261"/>
    <dbReference type="KEGG" id="ovi:T265_13093"/>
    <dbReference type="CTD" id="20327261"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="744"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="9">
        <location>
            <begin position="865"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="107814" checksum="8161AC042B08BD15" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN8</accession>
    <name>A0A074ZZN8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167558.1">
        <property type="nucleotide sequence ID" value="XM_009169294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN8"/>
    <dbReference type="STRING" id="6198.A0A074ZZN8"/>
    <dbReference type="GeneID" id="20327694"/>
    <dbReference type="KEGG" id="ovi:T265_13527"/>
    <dbReference type="CTD" id="20327694"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="478" mass="54044" checksum="E8603E5786537F3F" modified="2014-10-01" version="1" fragment="single">MFLLGACDCGGERPHHLFSELDEFWNDLSGSGETEWREAVRWNYRCVFCGKLFSFVESPERHVLEVHADEKSNEGMQNFTCKTSGNSHSAWYRIMRFRFQGVAHDQWTTVMTKNTSGKAWTSDCCAHLVFCEQHRIFAFQDILTVKDDSMVATVGLRIVKMNGFWGQRFPIRRFLEEINSNNFVDAEHPNLNVLGGRLRDKATRSSQPEKYGKPKTPRENNCDICGKSFLRLSDRRRHATVHTGSKNYKCEFCNKSFAQHTSLKGHKTVAHSSEQASGVDQNSVPVEIGACQQKTEEHSIGVIQYTEASKVLTTVCLSLGYVISECVLLCTNQRNCTGNYPPQKHSLITEMVLIPTADLITQSTKEARPPLSKILAQVQHNSQNGTGQTNNHLPIGQNTNTPLVTNMYRREAQPYTCNLCGKSFLAAAHLRRHAGVNTKSKNYLCDCCTKQFKYESSLKIHKQVAHPDKETEDSVAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A006</accession>
    <name>A0A075A006_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164685.1">
        <property type="nucleotide sequence ID" value="XM_009166421.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A006"/>
    <dbReference type="GeneID" id="20316421"/>
    <dbReference type="KEGG" id="ovi:T265_02233"/>
    <dbReference type="CTD" id="20316421"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1387" mass="148390" checksum="47D1B235CE8A553C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0B5</accession>
    <name>A0A075A0B5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163513.1">
        <property type="nucleotide sequence ID" value="XM_009165249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0B5"/>
    <dbReference type="STRING" id="6198.A0A075A0B5"/>
    <dbReference type="GeneID" id="20315452"/>
    <dbReference type="KEGG" id="ovi:T265_01264"/>
    <dbReference type="CTD" id="20315452"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043188">
        <property type="entry name" value="DCDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46302:SF3">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="110226" checksum="3A8E2530CF87702D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A194</accession>
    <name>A0A075A194_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596681">
        <property type="protein sequence ID" value="KER29310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166976.1">
        <property type="nucleotide sequence ID" value="XM_009168712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A194"/>
    <dbReference type="GeneID" id="20327571"/>
    <dbReference type="KEGG" id="ovi:T265_13404"/>
    <dbReference type="CTD" id="20327571"/>
    <dbReference type="OrthoDB" id="6232081at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705414" evidence="1">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="31970" checksum="81F427D01C71E632" modified="2014-10-01" version="1" fragment="single">MTSCFCFFISFLLGTISNAMANNCTLLPSDLLNCAQKQGVVRFPDDGAGYGFGFGTKWHLNVYACAHQTVVNRCATNAESHFRMRMWQFIFDASRYTRAAHYLCRLHNLSIFRMHRDSCLLPYEQQVNACSEAYTSLLAATTLRLAVNNPSNLTNEWAYADYMIQELTRTYCVGIKEKIQCVTARLKEPCTEDVISLVRNYYRETLPENCPTQAEEKTQIFGPVKRTTSGTSNPNKKIFQNSYLSKTSPSKGKSCRFSINYRRYFFIGLISVILKDTLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1T9</accession>
    <name>A0A075A1T9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_12648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162994.1">
        <property type="nucleotide sequence ID" value="XM_009164730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1T9"/>
    <dbReference type="STRING" id="6198.A0A075A1T9"/>
    <dbReference type="GeneID" id="20326816"/>
    <dbReference type="KEGG" id="ovi:T265_12648"/>
    <dbReference type="CTD" id="20326816"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="298"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="922" mass="101265" checksum="5EC2638375EA3EB0" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1V9</accession>
    <name>A0A075A1V9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162628.1">
        <property type="nucleotide sequence ID" value="XM_009164364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1V9"/>
    <dbReference type="STRING" id="6198.A0A075A1V9"/>
    <dbReference type="GeneID" id="20314748"/>
    <dbReference type="KEGG" id="ovi:T265_00560"/>
    <dbReference type="CTD" id="20314748"/>
    <dbReference type="OrthoDB" id="5242628at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14471" checksum="25F761C5D28B5D62" modified="2014-10-01" version="1">MSADPEVKRAIEAHRQQTIVANQQINILNAQLEALTMKHRRSELVEQELKALPTETVVYKALGRMFLRKSVNTITEDILKERLIIDNNMETLKVKICSLQKNKEAVSSNLSESKEALRELLSSKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A226</accession>
    <name>A0A075A226_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164042.1">
        <property type="nucleotide sequence ID" value="XM_009165778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A226"/>
    <dbReference type="GeneID" id="20315900"/>
    <dbReference type="KEGG" id="ovi:T265_01712"/>
    <dbReference type="CTD" id="20315900"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="38267" checksum="5D6E0FF1DA1ABB1C" modified="2014-10-01" version="1">MAGRLIPKFTFVEMVESSGAGDDREGYDGIIGMRRPPENAEDCEFLKTTILDYVLNAGIVNDGIFTFRFCGQHGVRGDSWFVHGNLEFGGTRNDYFYPPIVSLPLHQGTQWVVDITSIEYGDVVLCRLCRVHVDTGSPDTFAPAESSNKLLQNSVVEKHDDGMFHVLPHNLHHLHPLKIKLGSRVFTLLPKELTRFVNKLAYFLKFFLHFSIEYGDVVLCRLCRVHVDTGSPDTFAPAESSNKLLQNSVVEKHDDGMFHVLPHNLHHLHPLKIKLGSRVFTLLPKELTRFSVGFHHFAIQMEAKAAETTWTLGVSILRHFYLMFDQQSNQMGFAAVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3K6</accession>
    <name>A0A075A3K6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163366.1">
        <property type="nucleotide sequence ID" value="XM_009165102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3K6"/>
    <dbReference type="STRING" id="6198.A0A075A3K6"/>
    <dbReference type="GeneID" id="20315329"/>
    <dbReference type="KEGG" id="ovi:T265_01141"/>
    <dbReference type="CTD" id="20315329"/>
    <dbReference type="OrthoDB" id="10062389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11356" checksum="53FF1E3E59B19BCB" modified="2014-10-01" version="1">MARTAPKAAFGADSDALLIGFSMLEETPKSASSPAPVSTGVPQGSVLGPLLFLVYVNDLPNVLTSPRLVFADDLKSWSSKATALQMDVDAVKQWSLDWHLPLNDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A425</accession>
    <name>A0A075A425_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">inx</name>
        <name evidence="10" type="ORF">T265_03269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165966.1">
        <property type="nucleotide sequence ID" value="XM_009167702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A425"/>
    <dbReference type="GeneID" id="20317456"/>
    <dbReference type="KEGG" id="ovi:T265_03269"/>
    <dbReference type="CTD" id="20317456"/>
    <dbReference type="OrthoDB" id="6232833at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF36">
        <property type="entry name" value="INNEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="844"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="969" mass="111046" checksum="F569AF96F93BE5BF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A576</accession>
    <name>A0A075A576_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_02881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165498.1">
        <property type="nucleotide sequence ID" value="XM_009167234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A576"/>
    <dbReference type="STRING" id="6198.A0A075A576"/>
    <dbReference type="GeneID" id="20317069"/>
    <dbReference type="KEGG" id="ovi:T265_02881"/>
    <dbReference type="CTD" id="20317069"/>
    <dbReference type="OrthoDB" id="6222643at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="126"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="368" mass="42266" checksum="0BC1FDF565EFE113" modified="2014-10-01" version="1">MVGHKKKWKANKVNGILKNLLQRAVKRGEKADISEPELLEITDYMCDILLEDPVCLDLDLKEPICIVGDLFGQYMDLIEIFEVFGFPPGRRYLFLGNYCDRGPQSLEVICLLFILKLKFPKHIFMLRGNHECEYISCHYGFLADCTKRFSKQVWHGFMAAFNCLPATAIIEDIIFCAHSGLVPCLQYTSYTSVGQLKDYINDVIRRPVPLTHNFLLTQLAWSEPVIDTRDRCSNPAGLGEWFGEKEVEEFCDRFGFELFIRSHDFVKTGYEFMANGKLLTVFSASHFGGIFQNLGAAVMLEKRHRKNTILGRITVIRPTPQLTRIVGSYIPIVSYDSREYQAYREAHRDRLSIVEGYAATRGTYVFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Z5</accession>
    <name>A0A075A5Z5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_02610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165172.1">
        <property type="nucleotide sequence ID" value="XM_009166908.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A5Z5"/>
    <dbReference type="GeneID" id="20316798"/>
    <dbReference type="KEGG" id="ovi:T265_02610"/>
    <dbReference type="CTD" id="20316798"/>
    <dbReference type="OrthoDB" id="5983381at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704507" description="Collagen IV NC1 domain-containing protein" evidence="9">
        <location>
            <begin position="36"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="10">
        <location>
            <begin position="1544"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1190"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1779" mass="176725" checksum="C793FB5F10A54168" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A731</accession>
    <name>A0A075A731_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596859">
        <property type="protein sequence ID" value="KER23234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173028.1">
        <property type="nucleotide sequence ID" value="XM_009174764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A731"/>
    <dbReference type="STRING" id="6198.A0A075A731"/>
    <dbReference type="GeneID" id="20328847"/>
    <dbReference type="KEGG" id="ovi:T265_14681"/>
    <dbReference type="CTD" id="20328847"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13555" checksum="876E2792135B9D93" modified="2014-10-01" version="1" fragment="single">KNPTIVNYPFSRARWSNWLERESTDQKVRGLKPTSTFRLPLSRLGQPGSILALVSPSGGMAVRHRKVKVFEKTLVCESIWFLRESQLNLSFVIFYNWMCCTQAASRFSWRDIRDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAZ4</accession>
    <name>A0A075AAZ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163283.1">
        <property type="nucleotide sequence ID" value="XM_009165019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAZ4"/>
    <dbReference type="GeneID" id="20315264"/>
    <dbReference type="KEGG" id="ovi:T265_01076"/>
    <dbReference type="CTD" id="20315264"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8030" checksum="FEF6B4A424E8EFF6" modified="2014-10-01" version="1">MTKGIILIGTRIHLTFSNRNEITAVGRSKLTVLSAAEHCILIGLVIQARKVTVDHVLSDPRPTPDTVGIKRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB56</accession>
    <name>A0A075AB56_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171396.1">
        <property type="nucleotide sequence ID" value="XM_009173132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB56"/>
    <dbReference type="GeneID" id="20321754"/>
    <dbReference type="KEGG" id="ovi:T265_07575"/>
    <dbReference type="CTD" id="20321754"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14353" checksum="53C001C5D6FD45FD" modified="2014-10-01" version="1">MKAPSRSEWTYEDILNQGNNWLKHLITVDKDTSVHAKANGKQEYSPTIVKRGATVSAAEDFPIEASKGCPILTWRRHGGHNCRLYATTNDFQSQYREKQVLNQATEIVLGFHRMVHMDYMPQFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC04</accession>
    <name>A0A075AC04_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171053.1">
        <property type="nucleotide sequence ID" value="XM_009172789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC04"/>
    <dbReference type="STRING" id="6198.A0A075AC04"/>
    <dbReference type="GeneID" id="20321481"/>
    <dbReference type="KEGG" id="ovi:T265_07302"/>
    <dbReference type="CTD" id="20321481"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="384" mass="40388" checksum="2A5938BA69A7D604" modified="2014-10-01" version="1">MSSGQSFTHSATPILEGWLIKALRLVHSKKPGDQERLRKMYKDACENEAAVSRMTIAEALREPRDSSRSDTPEREPPVSTSTRIHPAPPFTDPQTANTQSASTGDPITVTTSTNPSDNSVPSAVQSSAAGKTSKRTKVAFFNMFDPSSSSSMRPTSNPAVVKSALSSSNPSSVVIDLTTSPSYQSAVRPVDVLVPANTTTTTTDVSQSCHTVSSMPGSLNTTAIDLTVTESVTQAAGSSSSSSTTQDKLAGPADAHFVASLVADLTCCVCGKITPQPQLEPDGKTMSSNVLVECCQCGALYHQLCHQPPVLSSRGTNPQQWLCTNCTQVAEPTTLSDPVVLIETFSADATSDVRQIPSPGPNTGARKRKAGLTGSAMSSSIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADY8</accession>
    <name>A0A075ADY8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169871.1">
        <property type="nucleotide sequence ID" value="XM_009171607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADY8"/>
    <dbReference type="STRING" id="6198.A0A075ADY8"/>
    <dbReference type="GeneID" id="20320548"/>
    <dbReference type="KEGG" id="ovi:T265_06366"/>
    <dbReference type="CTD" id="20320548"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="18880" checksum="A8FE14541BF0720F" modified="2014-10-01" version="1">MSPTLHSIEADLRVTTYCWHAPSLISTIKLVAHKKESHVPQNDLGSVEVYSPEVIMWIRKGDTTKFPPESEDALIQVVYGDVIKTFRMRGSAKYQHLDPPSPIRPGGTYKYSHTSAISHSLPKASSSPFRDCSSFKTEPFYFIQSQLYLNHFYRRFVYIYPWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF14</accession>
    <name>A0A075AF14_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596727">
        <property type="protein sequence ID" value="KER27269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169001.1">
        <property type="nucleotide sequence ID" value="XM_009170737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF14"/>
    <dbReference type="GeneID" id="20319854"/>
    <dbReference type="KEGG" id="ovi:T265_05672"/>
    <dbReference type="CTD" id="20319854"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="20458" checksum="2BD7BAA041D53E18" modified="2014-10-01" version="1">MLGIGKQEVRGSLTSHPISDEKEASRNRNHKREDTYLRYEKLKVLQSFGLECTVEFENLGWRREESPHVTHPSNQCDVRLLGMAGLRTLNHSHPAIKGKQQSKTIENSRMIREGNLTNGHMAKINDLKAAFVSIDRQKPWLSLAIKRVSVQSYLFCVRTPVDSYGYTTGCCLNRSRQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AF53</accession>
    <name>A0A075AF53_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168885.1">
        <property type="nucleotide sequence ID" value="XM_009170621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AF53"/>
    <dbReference type="GeneID" id="20327976"/>
    <dbReference type="KEGG" id="ovi:T265_13809"/>
    <dbReference type="CTD" id="20327976"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="695" mass="76837" checksum="6920417671348A1E" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG24</accession>
    <name>A0A075AG24_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167953.1">
        <property type="nucleotide sequence ID" value="XM_009169689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG24"/>
    <dbReference type="STRING" id="6198.A0A075AG24"/>
    <dbReference type="GeneID" id="20319025"/>
    <dbReference type="KEGG" id="ovi:T265_04843"/>
    <dbReference type="CTD" id="20319025"/>
    <dbReference type="OrthoDB" id="6282232at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="17022" checksum="DF19B8F09B0E4011" modified="2014-10-01" version="1">MGRPGAAHSVAWKHHNREIQMGSRPPHDSVRTIFEISHYIFIKETTDKVAENSSTAHDRFLPSRGSSGRRSPRVSVNLMIYLNPNWTVFLRIHNHLQTNLVFSRDSPGTRVNLSFVMFSDCRRIFSNLMSSTLQDIRVSRHLEYRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGI2</accession>
    <name>A0A075AGI2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167548.1">
        <property type="nucleotide sequence ID" value="XM_009169284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGI2"/>
    <dbReference type="GeneID" id="20318711"/>
    <dbReference type="KEGG" id="ovi:T265_04529"/>
    <dbReference type="CTD" id="20318711"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6516" checksum="ECF276B2AB013991" modified="2014-10-01" version="1">MTQNAKLADEPVVDSGARYHACEPSQDEIAARRSKPMMLIGLPSIEDRAATRALHGHSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGI6</accession>
    <name>A0A075AGI6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596692">
        <property type="protein sequence ID" value="KER28754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167503.1">
        <property type="nucleotide sequence ID" value="XM_009169239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGI6"/>
    <dbReference type="GeneID" id="20327681"/>
    <dbReference type="KEGG" id="ovi:T265_13514"/>
    <dbReference type="CTD" id="20327681"/>
    <dbReference type="OrthoDB" id="6288872at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112997" checksum="6256BF54FB313A67" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGR4</accession>
    <name>A0A075AGR4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167244.1">
        <property type="nucleotide sequence ID" value="XM_009168980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGR4"/>
    <dbReference type="GeneID" id="20318463"/>
    <dbReference type="KEGG" id="ovi:T265_04281"/>
    <dbReference type="CTD" id="20318463"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10498" checksum="D285A31B65327E78" modified="2014-10-01" version="1">MLDEKIGSPTKELWSTKHTKLLWVEQWHFQTKPPPVNVEKVLAVLQTMLAYMYLINHRMVATERSITPVFTNTAERQNMLKCDFLFYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGV4</accession>
    <name>A0A075AGV4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167138.1">
        <property type="nucleotide sequence ID" value="XM_009168874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGV4"/>
    <dbReference type="GeneID" id="20318378"/>
    <dbReference type="KEGG" id="ovi:T265_04192"/>
    <dbReference type="CTD" id="20318378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="168" mass="18914" checksum="618B2A5A5BA409CF" modified="2014-10-01" version="1">MLKIRKTVIITTEDLEQDQQTNGLELSSRLREKKLRDDNVMEGDRCKLAAGDIREEEFLTDVVSPTLGRPGNTDNVDPKKGLAPSNSKWGSSSSWRMRMRTGHASGLPHAAFILEAKKTGVRMRISTNHVIPVRTHWRNNTNSGTNPPPQTENTFQAEAQLEVKFEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH78</accession>
    <name>A0A075AH78_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein asunder</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Integrator subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166770.1">
        <property type="nucleotide sequence ID" value="XM_009168506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH78"/>
    <dbReference type="STRING" id="6198.A0A075AH78"/>
    <dbReference type="GeneID" id="20318092"/>
    <dbReference type="KEGG" id="ovi:T265_03905"/>
    <dbReference type="CTD" id="20318092"/>
    <dbReference type="OrthoDB" id="5844105at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019355">
        <property type="entry name" value="Cell_cycle_regulator_Mat89Bb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12955">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-95-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10221">
        <property type="entry name" value="Mat89Bb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="82750" checksum="AB9E50B55B71B67A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIB4</accession>
    <name>A0A075AIB4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_12997</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164935.1">
        <property type="nucleotide sequence ID" value="XM_009166671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIB4"/>
    <dbReference type="STRING" id="6198.A0A075AIB4"/>
    <dbReference type="GeneID" id="20327165"/>
    <dbReference type="KEGG" id="ovi:T265_12997"/>
    <dbReference type="CTD" id="20327165"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="12">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="206"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="104625" checksum="0A183BAA928EBC3F" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIC7</accession>
    <name>A0A075AIC7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164796.1">
        <property type="nucleotide sequence ID" value="XM_009166532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIC7"/>
    <dbReference type="GeneID" id="20316506"/>
    <dbReference type="KEGG" id="ovi:T265_02318"/>
    <dbReference type="CTD" id="20316506"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6330" checksum="A7F239938A2F622F" modified="2014-10-01" version="1">MKPTCPLKSGTTYVVKMDVPALLQPHRVTPGTVESSKLAGSISPRSSPHRITSGDAWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIW0</accession>
    <name>A0A075AIW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163871.1">
        <property type="nucleotide sequence ID" value="XM_009165607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIW0"/>
    <dbReference type="GeneID" id="20315736"/>
    <dbReference type="KEGG" id="ovi:T265_01548"/>
    <dbReference type="CTD" id="20315736"/>
    <dbReference type="OrthoDB" id="6249991at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="661" mass="73975" checksum="474A8976BE3E1366" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIZ0</accession>
    <name>A0A075AIZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163826.1">
        <property type="nucleotide sequence ID" value="XM_009165562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIZ0"/>
    <dbReference type="GeneID" id="20315709"/>
    <dbReference type="KEGG" id="ovi:T265_01521"/>
    <dbReference type="CTD" id="20315709"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8945" checksum="ECC476E7101E91B0" modified="2014-10-01" version="1">MNHVDWASATICYRQHNPMHEGVQIRFNFHKEPDFRVGECNMNGDWQRSVDSNRGPPDERQYTRSTTWYYQPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJS7</accession>
    <name>A0A075AJS7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162353.1">
        <property type="nucleotide sequence ID" value="XM_009164089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJS7"/>
    <dbReference type="STRING" id="6198.A0A075AJS7"/>
    <dbReference type="GeneID" id="20314532"/>
    <dbReference type="KEGG" id="ovi:T265_00344"/>
    <dbReference type="CTD" id="20314532"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="382" mass="42554" checksum="3F8988BF5C93F06E" modified="2014-10-01" version="1">MEKRYGCIFSCMGYPTIHLEVAHSLTTDSSILALMRFVGRRGRPLDIYTDNGSNFVGAVSLWGQAKINNRLLARGIQWHFNPPLASHRGGVWGRMIRSVRQIIFVLIQEQILSDDCLSTFFVEVERILNDRPLTSLTADSRDALAPTPNHPLLHKANAVDEQLRANKRAISRAVRELDAEKRRLEQDKTRIKTEIKKLAKQNEMDAVRILAKQIVRNDHYCKKFTLMRTNLEAVSLKLQTLKSTNAMGQTMKQVTQVMKRMNASMKLPQLQRIMMDFEKESGLLDSKEEMMSDAIDDALGEDDIDESEAIVNSVLAELGIEMNEQLSNLPGSGTVATGQANTPGRIAIPTPAGPAGPAGSGSMDGTIDEDDLEARLARLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWV8</accession>
    <name>A0A074YWV8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597258">
        <property type="protein sequence ID" value="KER19286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176970.1">
        <property type="nucleotide sequence ID" value="XM_009178706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWV8"/>
    <dbReference type="GeneID" id="20326057"/>
    <dbReference type="KEGG" id="ovi:T265_11889"/>
    <dbReference type="CTD" id="20326057"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12155" checksum="E0F81EA8D66B5FAA" modified="2014-10-01" version="1">MSAQAWAGEVEMRRLGTDHAYSDRFKGAAATGVSRALLSSLRLGRRFAAELCNLVGNIPYHDLRVFKLFMLIPHRSIIVQNFCHAVPDDEDDDDGHDDDHDDEMRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXD7</accession>
    <name>A0A074YXD7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597245">
        <property type="protein sequence ID" value="KER19318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176933.1">
        <property type="nucleotide sequence ID" value="XM_009178669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXD7"/>
    <dbReference type="GeneID" id="20326038"/>
    <dbReference type="KEGG" id="ovi:T265_11870"/>
    <dbReference type="CTD" id="20326038"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="60" mass="6817" checksum="B7CEC0DB66708766" modified="2014-10-01" version="1">MFESTLKAFVFVRVRSMRSLNEAAHWCFKDKHATVPNYSSGGLRTISVASRRGRAEKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ26</accession>
    <name>A0A074YZ26_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601019">
        <property type="protein sequence ID" value="KER18462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177790.1">
        <property type="nucleotide sequence ID" value="XM_009179526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ26"/>
    <dbReference type="GeneID" id="20330203"/>
    <dbReference type="KEGG" id="ovi:T265_16038"/>
    <dbReference type="CTD" id="20330203"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9225" checksum="213DC9D59E34F2E7" modified="2014-10-01" version="1" fragment="single">MRKFILKSPRLECVVFNLYPTRTQTFNQNLQKLTFSFRLHLIDNCIEPTRSLNTSVTALHIENHCLDPVAPCQIGPVHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1A0</accession>
    <name>A0A074Z1A0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597026">
        <property type="protein sequence ID" value="KER20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175520.1">
        <property type="nucleotide sequence ID" value="XM_009177256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1A0"/>
    <dbReference type="GeneID" id="20324954"/>
    <dbReference type="KEGG" id="ovi:T265_10786"/>
    <dbReference type="CTD" id="20324954"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9363" checksum="628C106D3BB1FA9B" modified="2014-10-01" version="1">MLPWSTTPTSLRKHMRRTTDYSSDEPDSSQLSQRSDIHRPDREGRVYTKIDSLNAQKNIVNALIVDFDDLSDAPNGPYAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1C4</accession>
    <name>A0A074Z1C4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597259">
        <property type="protein sequence ID" value="KER19282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176972.1">
        <property type="nucleotide sequence ID" value="XM_009178708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1C4"/>
    <dbReference type="STRING" id="6198.A0A074Z1C4"/>
    <dbReference type="GeneID" id="20326059"/>
    <dbReference type="KEGG" id="ovi:T265_11891"/>
    <dbReference type="CTD" id="20326059"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9811" checksum="6D270077FB8A36DA" modified="2014-10-01" version="1">MPEANKDTTTHQMQQVVVTRYRLIVQNPCDHRGHLGESLCPSAVCRRLSWTPIPDPVPPPREYPPKGALPPRQRYDNYENYGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2M3</accession>
    <name>A0A074Z2M3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_15460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597143">
        <property type="protein sequence ID" value="KER19757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176497.1">
        <property type="nucleotide sequence ID" value="XM_009178233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2M3"/>
    <dbReference type="STRING" id="6198.A0A074Z2M3"/>
    <dbReference type="GeneID" id="20329625"/>
    <dbReference type="KEGG" id="ovi:T265_15460"/>
    <dbReference type="CTD" id="20329625"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21994">
        <property type="entry name" value="HMG-box_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000119">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF00505">
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    </dbReference>
    <dbReference type="Pfam" id="PF21103">
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    </dbReference>
    <dbReference type="Pfam" id="PF17292">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="684"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER19757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="755" mass="84529" checksum="B75F054EBF6D9B99" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2W6</accession>
    <name>A0A074Z2W6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_15098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596969">
        <property type="protein sequence ID" value="KER21411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009176573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2W6"/>
    <dbReference type="GeneID" id="20329263"/>
    <dbReference type="KEGG" id="ovi:T265_15098"/>
    <dbReference type="CTD" id="20329263"/>
    <dbReference type="OrthoDB" id="6253936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="165" mass="18489" checksum="D11B07B2EDAF7F3D" modified="2014-10-01" version="1">MPSTINPDLIAVRERRATVIDISVVWDGRGVTEWTLRQRFGTPTNDHFLLRDLLSVKAGIRLGHPNSVTCVRLPFLTLSVLMTFLCVVHGTDRSLLRLAFTPDPMTDTLCLMCESEAYTIFGELGASTLTSFITHDLIAVRERRATVIDISVVWDGRGVTEWSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4I6</accession>
    <name>A0A074Z4I6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER22006.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4I6"/>
    <dbReference type="GeneID" id="20323968"/>
    <dbReference type="KEGG" id="ovi:T265_09800"/>
    <dbReference type="CTD" id="20323968"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13674" checksum="1735A62A6020DC32" modified="2014-10-01" version="1">MSIEFDQLRELLQQQQKQFEEAQLKLIESLTQKLHIQTAAVSTARVLPSTHSSKELIRLTPLQQRHQQVATVSIYTMDLRFLSPVIRITNPRTSSSLLAFSSQRPKARESKATGPQQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4K3</accession>
    <name>A0A074Z4K3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER21998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174251.1">
        <property type="nucleotide sequence ID" value="XM_009175987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4K3"/>
    <dbReference type="STRING" id="6198.A0A074Z4K3"/>
    <dbReference type="GeneID" id="20329122"/>
    <dbReference type="KEGG" id="ovi:T265_14956"/>
    <dbReference type="CTD" id="20329122"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="232"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="438" mass="48549" checksum="D2AF1C7BC7AFE5B9" modified="2014-10-01" version="1" fragment="single">TTHKFAEKSSAALSHLRPSWGSSERRSPRVSVSLMFYLNPNRTVFEKYTNLQVNSVFTRDSTGSLVYDILQLNVLHTGRLMIHLSRYSRFCIPEFPSSLCSNPTQIGLFSRNTLICKSIRFSQETQLDLSDILIQLARYSRFCNVTQMIISQTIGGLCNGFFGGQPLIVLLSTAPLALYIKSLGDLAVSQPSCLLRVAPQLGTGSVLQLNDFSCIGQVICSEDSSSKRIRSRIVYTICESFGLNFPAMYGCVGLFNSLFLFGFSVTGLSSLMRWSTRSTEEIFALFVSVAFIMGAVKDCYKTFQKYYVCQPPTQMMEANQTNKTLKNIIGFTANSAEHLDENLSKEAGFLLESSSCNKEVALLYLLLLLGTVWLSLYLYNFTKTPFLTAGKREILTDFALPIAVLVMSTVGSLLSGNISCFRPIRPRLDAGPASVPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4P9</accession>
    <name>A0A074Z4P9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604539">
        <property type="protein sequence ID" value="KER18280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177973.1">
        <property type="nucleotide sequence ID" value="XM_009179709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4P9"/>
    <dbReference type="GeneID" id="20330330"/>
    <dbReference type="KEGG" id="ovi:T265_16165"/>
    <dbReference type="CTD" id="20330330"/>
    <dbReference type="OrthoDB" id="6238737at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10210" checksum="4260241C63E320F5" modified="2014-10-01" version="1" fragment="single">CADDGVPLSIKDCLPHLCKLIDDASSTGTFSQSPVYTFSHLPDGMNPPTSLSNTIPKLYIAESLPASYSGLILLGRTQEYTTAAQKFYRAALKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5S1</accession>
    <name>A0A074Z5S1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599177">
        <property type="protein sequence ID" value="KER18615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177638.1">
        <property type="nucleotide sequence ID" value="XM_009179374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5S1"/>
    <dbReference type="STRING" id="6198.A0A074Z5S1"/>
    <dbReference type="GeneID" id="20330103"/>
    <dbReference type="KEGG" id="ovi:T265_15938"/>
    <dbReference type="CTD" id="20330103"/>
    <dbReference type="OrthoDB" id="9934270at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19620" checksum="EC3E9F074B2697C2" modified="2014-10-01" version="1" fragment="single">LQHPPVNAQGIDNHFSAAFIEAFLEAVTGKAERSSSVNQFSNSVPISPTPVSPAATNVATASTWQDVAMHDGAILMFSVRASSGHSLVNLYTAPIVTNQMDAQWFKHVEFDQWTVGRYRRVMLELWHANQPVVRLTFNAEYADRYTWFQKALLIESFPWYENELIQETVFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6S4</accession>
    <name>A0A074Z6S4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597448">
        <property type="protein sequence ID" value="KER18940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177313.1">
        <property type="nucleotide sequence ID" value="XM_009179049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6S4"/>
    <dbReference type="GeneID" id="20326258"/>
    <dbReference type="KEGG" id="ovi:T265_12090"/>
    <dbReference type="CTD" id="20326258"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="7127" checksum="5F8DBF64704EAF0E" modified="2014-10-01" version="1">MQQRINRCRTRRLEILNEVRQITNEMFDRLKRGLPTPNELKATFQRLADLLEELKSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z894</accession>
    <name>A0A074Z894_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596850">
        <property type="protein sequence ID" value="KER23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172839.1">
        <property type="nucleotide sequence ID" value="XM_009174575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z894"/>
    <dbReference type="GeneID" id="20322880"/>
    <dbReference type="KEGG" id="ovi:T265_08701"/>
    <dbReference type="CTD" id="20322880"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="28654" checksum="247FB6A31B22FA55" modified="2014-10-01" version="1">MSVVTTIPTESKTSGTGAEQAVDLCQLINEATSENTERNSGRNSYFWSSKGRPSLPDVGHTNNAPSQPRTKARQRESALDQGQTTPLYMQCITALYGSQTMIRSKKRPKTPPTNLEIRDVQEMDIPNDMVSLNQRFHDKTTQEKFLIPSELRTGDHFDNFTKVVQSDPIVIEDDEDIGGHTTERRISGTKSPSSSLQLTSTSVTSSITSSLSSIHMTVSCASTGPTIARVTSLCQPNIQVSQASYIFALKTRPTPIVLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8L1</accession>
    <name>A0A074Z8L1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596845">
        <property type="protein sequence ID" value="KER23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172709.1">
        <property type="nucleotide sequence ID" value="XM_009174445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8L1"/>
    <dbReference type="STRING" id="6198.A0A074Z8L1"/>
    <dbReference type="GeneID" id="20322772"/>
    <dbReference type="KEGG" id="ovi:T265_08593"/>
    <dbReference type="CTD" id="20322772"/>
    <dbReference type="OrthoDB" id="6276049at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="553" mass="62731" checksum="1EFB883829655612" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Y6</accession>
    <name>A0A074Z8Y6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596923">
        <property type="protein sequence ID" value="KER22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174203.1">
        <property type="nucleotide sequence ID" value="XM_009175939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8Y6"/>
    <dbReference type="GeneID" id="20323935"/>
    <dbReference type="KEGG" id="ovi:T265_09767"/>
    <dbReference type="CTD" id="20323935"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="268" mass="29502" checksum="6B46D698227C4D11" modified="2014-10-01" version="1">MLYLSSRSYSLTNTHVQINDNSQAASSEPVLETTRHVLLAKLEKHLISDLPPENVGDSSFEKLLETPAVAAVKSPRNQTNTTNDSTATEVTNGSLSFNSPAQKSSPILEYASRLPSYRRRSIHPERPDLTNPYTDLILPDSVTLLSSRPYSPSDKATPWKRTAGSEKWSVTKKIKDLRSPVSRSVVALINAVRALIVATLKRESTDCKVRGSNPTSASRLPLSRLRQPDSISALVLPPGGMAARHWVLQLNGLLFSIWLITSRCHMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAI7</accession>
    <name>A0A074ZAI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZMYM2-like/QRICH1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597076">
        <property type="protein sequence ID" value="KER20230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176023.1">
        <property type="nucleotide sequence ID" value="XM_009177759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20325338"/>
    <dbReference type="KEGG" id="ovi:T265_11170"/>
    <dbReference type="CTD" id="20325338"/>
    <dbReference type="OrthoDB" id="2434995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042838">
        <property type="entry name" value="KIAA1958"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46963">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA E130308A19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="265"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="1740"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1968"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1968"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1989"/>
            <end position="2024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2024" mass="219941" checksum="F82C8D1A6C1A9A45" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAZ1</accession>
    <name>A0A074ZAZ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171773.1">
        <property type="nucleotide sequence ID" value="XM_009173509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAZ1"/>
    <dbReference type="GeneID" id="20328574"/>
    <dbReference type="KEGG" id="ovi:T265_14408"/>
    <dbReference type="CTD" id="20328574"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="487"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER24471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="596" mass="65580" checksum="EC08AE69F5DD7909" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBA9</accession>
    <name>A0A074ZBA9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173396.1">
        <property type="nucleotide sequence ID" value="XM_009175132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBA9"/>
    <dbReference type="GeneID" id="20323314"/>
    <dbReference type="KEGG" id="ovi:T265_09135"/>
    <dbReference type="CTD" id="20323314"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11817" checksum="DABC41E6C96151A1" modified="2014-10-01" version="1">MSSTEHRDGPMDPMLKGNLPYSNRRNALFIRLLKTVRWPTTGFTLLGTHQGDLSGYLVYDVLQLNVLHKGRLMFQLVRYSRNRGSSFTKDTTHKVAENSAEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBK3</accession>
    <name>A0A074ZBK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596807">
        <property type="protein sequence ID" value="KER24523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171732.1">
        <property type="nucleotide sequence ID" value="XM_009173468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBK3"/>
    <dbReference type="GeneID" id="20322014"/>
    <dbReference type="KEGG" id="ovi:T265_07835"/>
    <dbReference type="CTD" id="20322014"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13693" checksum="AA8EED3F9A90F324" modified="2014-10-01" version="1">MPVANGPSRTRQNFQKAITTYAIYTKHCTTVLDFVLGVDRPCAPLLTCKCFVTHTRRPSQLRTGDVFSYGGETFASQMPSSLTCKCFVTHTRRPSQLRTGDVFSYGGETFASQMPSSVNRPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCI2</accession>
    <name>A0A074ZCI2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA primase</fullName>
            <ecNumber evidence="2">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
    <dbReference type="EMBL" id="KL597010">
        <property type="protein sequence ID" value="KER20910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175339.1">
        <property type="nucleotide sequence ID" value="XM_009177075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCI2"/>
    <dbReference type="STRING" id="6198.A0A074ZCI2"/>
    <dbReference type="GeneID" id="20324806"/>
    <dbReference type="KEGG" id="ovi:T265_10638"/>
    <dbReference type="CTD" id="20324806"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="388" mass="43535" checksum="D0C71451C5C206DF" modified="2014-10-01" version="1">MKTFADKLTCTGHCRLPGCGPRDVTHQWLDIVRDSDTVVLPEWKELVFDIDLTDYDEVRYCCGEQSENAKSAVCSRCWLLAQSAVLCVDRALREDFGFEHLLWVYSGRRGVHCWVCDPAARKLDTVARTAIVEYLTLVRGGNSRKPILTAGGLTKYESRGIGAPEPVLHPCVDAACDILLPRFAEYCSTKRGQDLFGVPARLKKLLSYLPEDLEELRSHMAEDWLEHPSNGMEEVSLKRWNTLRTFLKEHKRNNVLKELVLNYTYPRLDANVSTSLNHLLKSPFCIHPKTSYVCVPFDPQQVTSLNPVDVPTLSQLVEQARAGDVESSVADSSSGRHLLSYKRTALKASIDYFEAFIQRLCPADVEATTMTPGSTVDGSHKMPSVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCY0</accession>
    <name>A0A074ZCY0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171214.1">
        <property type="nucleotide sequence ID" value="XM_009172950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCY0"/>
    <dbReference type="STRING" id="6198.A0A074ZCY0"/>
    <dbReference type="GeneID" id="20321611"/>
    <dbReference type="KEGG" id="ovi:T265_07432"/>
    <dbReference type="CTD" id="20321611"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="619" mass="69743" checksum="AA3F80E8C5CEDA88" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD3</accession>
    <name>A0A074ZDD3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596984">
        <property type="protein sequence ID" value="KER21205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175045.1">
        <property type="nucleotide sequence ID" value="XM_009176781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD3"/>
    <dbReference type="GeneID" id="20324583"/>
    <dbReference type="KEGG" id="ovi:T265_10415"/>
    <dbReference type="CTD" id="20324583"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12096" checksum="8873E57561E68F5F" modified="2014-10-01" version="1">MGGTISCPNLVDHASAVALCTTLGRNSSCLELEFTHRKVCGSNLTSASRFPLSRLGQPGSIPALVLPSGGMAARYRKGTTAERLKETAHKVIENSSTAHDRFHPTWGSSVMDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE96</accession>
    <name>A0A074ZE96_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596775">
        <property type="protein sequence ID" value="KER25493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170757.1">
        <property type="nucleotide sequence ID" value="XM_009172493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE96"/>
    <dbReference type="STRING" id="6198.A0A074ZE96"/>
    <dbReference type="GeneID" id="20321243"/>
    <dbReference type="KEGG" id="ovi:T265_07064"/>
    <dbReference type="CTD" id="20321243"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="33457" checksum="75650381516536DD" modified="2014-10-01" version="1">MTFGIDVPSVADFLGNIDVQSEQLFEGIASFVNSVSRRRLGKLDRHSVVDYLRAKTVPSVSMLTALIFIEKIANTDPPPQLLDEITAVDLFAIAMTTASKYLYDIDTVDGSDNASWADVFNMDVQDLNQLEIRFLSAMDWSLFVAKSEYDRFRSLVHSLSSATSGRSLRSHSAKRSTRDTVARIQLKNKRLRTTAKLLAVFTAACLTSMAKDPGLFFQFESSPGSNTRSIYPLISLTLHTNPTTSPLRCTVNSSVDGTDDSCILSRLTSDHWHSVLLNYTPHVSTTASTSIANQMTDILLVCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF29</accession>
    <name>A0A074ZF29_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596763">
        <property type="protein sequence ID" value="KER25896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170359.1">
        <property type="nucleotide sequence ID" value="XM_009172095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF29"/>
    <dbReference type="STRING" id="6198.A0A074ZF29"/>
    <dbReference type="GeneID" id="20320929"/>
    <dbReference type="KEGG" id="ovi:T265_06750"/>
    <dbReference type="CTD" id="20320929"/>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="6">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="262" mass="30031" checksum="C9BFADF14CC2482D" modified="2014-10-01" version="1">MSDNLSHQFTFGAVAPMDSRLSEHIIKQYLISRNFTGTLDAFDAECNREKVRHRVSDLSHSRILFQPSSITVSLRDAINESNLGRLTEIWSSLHKTFFYRLDADRQQMAHSFKVHVFKTYVVHAFSQRRTSKVTEFFNGLSSEFCPNLPEWKNWYALPHTPDASEQPEYAMYFTKTWMDILSLSLTNFLCALFSLELCSTNVLTRLNELETQVSNSTDRTDKPPGLPTTSTTSPPFGKLLDDFNELGSLRPTAVTRPRDSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFG8</accession>
    <name>A0A074ZFG8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Channel protein, MIP family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171870.1">
        <property type="nucleotide sequence ID" value="XM_009173606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFG8"/>
    <dbReference type="STRING" id="6198.A0A074ZFG8"/>
    <dbReference type="GeneID" id="20322120"/>
    <dbReference type="KEGG" id="ovi:T265_07941"/>
    <dbReference type="CTD" id="20322120"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31707" checksum="6B66222B54278B21" modified="2014-10-01" version="1">MAGSLSSYEYEKVSCQSKYENTIHRWADKMRLTRFPLLRVFIGELAGTMILIIFGDSVVAQSVFASNVSAFSVSFGWGLAVIFGIFTSGTMGYGLLNPAVALAFAFNGKVPWIAVPVATIAELIGAFLGGLIVYCNYQVNIQLLDPGLTTKTLGIFCTGPSNAGNLPGFYDQIIGTALLGVMVLAIGDKYNFNIPGHVIPIYIGFLVGGLVGALGVNAGAALNPARDFGPRLAALTVGYKDAFTSYDSYCWVPIVGPYIGAILGVLLYELIIGVHVRGLKEEEERQKKLKDYDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGZ6</accession>
    <name>A0A074ZGZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171315.1">
        <property type="nucleotide sequence ID" value="XM_009173051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGZ6"/>
    <dbReference type="GeneID" id="20321693"/>
    <dbReference type="KEGG" id="ovi:T265_07514"/>
    <dbReference type="CTD" id="20321693"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="22401" checksum="F8CD74FE3FF6CE06" modified="2014-10-01" version="1">MHLGEERIQFSSVLHSSAPDWHFNANSYYGTGTSILAMNFENVVLFFGTLTLFSPVKRCMQTVTLLFIPELYPSGELAGFRRSLHTLNFLIMFEMSTVDTTSTRSSTLVWPVEAIALPPLHQCTLDARLQGRAMLLCATSSCQRRNEANRASVEEFHQLIRRSGRFDCFTHEDHVRRLDMVQTQQWYRMHERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH46</accession>
    <name>A0A074ZH46_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169725.1">
        <property type="nucleotide sequence ID" value="XM_009171461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH46"/>
    <dbReference type="STRING" id="6198.A0A074ZH46"/>
    <dbReference type="GeneID" id="20320433"/>
    <dbReference type="KEGG" id="ovi:T265_06251"/>
    <dbReference type="CTD" id="20320433"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="338" mass="37911" checksum="A4BE36E4FD3F1805" modified="2014-10-01" version="1">MGRSVVRAPPMPLEFPCPGLGNLAVSQSSCFFRVAWQLRTEKLLQLNDSKKELHEQTGAIGKMVHEATATACCGCWLEREFTDRKVRGSNPTSASRIPLSRLGRPGSIPALVLPSGGMAARHRKGVAAGRFFIVYGVRYDGLKYGYRAKQGPDSSKVSELQEDLNSTEALFAATRSQGFGDVVRGRILAGNFFLLRTQRDRHLDAARRLWRLIKEDFEKAGSIVDLPLSIFRTQSGVRQGYPFSPFLLNLATDEIVRRMLEVLQNPEYAGDIVLIFVEEEKAQVFLDELTKVIPSFGMHFAPTKCKVMLVDMQSLNTPFTTQRKHRSCGAFYISWKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHU2</accession>
    <name>A0A074ZHU2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170926.1">
        <property type="nucleotide sequence ID" value="XM_009172662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHU2"/>
    <dbReference type="GeneID" id="20321385"/>
    <dbReference type="KEGG" id="ovi:T265_07206"/>
    <dbReference type="CTD" id="20321385"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="7008" checksum="FC344CC3240E46CE" modified="2014-10-01" version="1">MSFKKGDEKAGFSNWRHTYRSLRSDCTSSRTLTHKPQKTMMHTYRVQFADILICTHSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIF9</accession>
    <name>A0A074ZIF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169483.1">
        <property type="nucleotide sequence ID" value="XM_009171219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIF9"/>
    <dbReference type="STRING" id="6198.A0A074ZIF9"/>
    <dbReference type="GeneID" id="20320231"/>
    <dbReference type="KEGG" id="ovi:T265_06049"/>
    <dbReference type="CTD" id="20320231"/>
    <dbReference type="OrthoDB" id="10061772at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="156"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="891" mass="98994" checksum="5101D86E2E5791DC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ22</accession>
    <name>A0A074ZJ22_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596853">
        <property type="protein sequence ID" value="KER23345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172908.1">
        <property type="nucleotide sequence ID" value="XM_009174644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ22"/>
    <dbReference type="GeneID" id="20322934"/>
    <dbReference type="KEGG" id="ovi:T265_08755"/>
    <dbReference type="CTD" id="20322934"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14700" checksum="B7B2D2E5CD860E85" modified="2014-10-01" version="1">MRPCECRGDNLQYSSTGRQAKCANRHTTPSENVVQISDSREEDTFLVVLSLKNRSPPAAAPFRCLTPMPSEGSMKARILTSCPRSRHRGRVRTTDVPVEKDRKRMYTEGAQVPAEVTEKEYSREETAILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJN6</accession>
    <name>A0A074ZJN6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172676.1">
        <property type="nucleotide sequence ID" value="XM_009174412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJN6"/>
    <dbReference type="STRING" id="6198.A0A074ZJN6"/>
    <dbReference type="GeneID" id="20322746"/>
    <dbReference type="KEGG" id="ovi:T265_08567"/>
    <dbReference type="CTD" id="20322746"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1210" mass="130589" checksum="E28C5A79CF5312C5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJX1</accession>
    <name>A0A074ZJX1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170171.1">
        <property type="nucleotide sequence ID" value="XM_009171907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJX1"/>
    <dbReference type="STRING" id="6198.A0A074ZJX1"/>
    <dbReference type="GeneID" id="20320782"/>
    <dbReference type="KEGG" id="ovi:T265_06603"/>
    <dbReference type="CTD" id="20320782"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="8">
        <location>
            <begin position="325"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127582" checksum="85D5DDD1A869303D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKM4</accession>
    <name>A0A074ZKM4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169892.1">
        <property type="nucleotide sequence ID" value="XM_009171628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKM4"/>
    <dbReference type="STRING" id="6198.A0A074ZKM4"/>
    <dbReference type="GeneID" id="20320559"/>
    <dbReference type="KEGG" id="ovi:T265_06380"/>
    <dbReference type="CTD" id="20320559"/>
    <dbReference type="OrthoDB" id="10061042at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="74799" checksum="1966895211C30891" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKU8</accession>
    <name>A0A074ZKU8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168277.1">
        <property type="nucleotide sequence ID" value="XM_009170013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKU8"/>
    <dbReference type="GeneID" id="20319278"/>
    <dbReference type="KEGG" id="ovi:T265_05096"/>
    <dbReference type="CTD" id="20319278"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8531" checksum="4BC8F94AF37EBAFD" modified="2014-10-01" version="1">MKLSQLVEFDATWRHMISREPFGDGLGQRTLMIVQGSSSEWFLNIIDFEDGLKDFDPRDARNFETLPSVHQAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLT4</accession>
    <name>A0A074ZLT4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168185.1">
        <property type="nucleotide sequence ID" value="XM_009169921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLT4"/>
    <dbReference type="GeneID" id="20319203"/>
    <dbReference type="KEGG" id="ovi:T265_05021"/>
    <dbReference type="CTD" id="20319203"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7782" checksum="1F1B802C42F88750" modified="2014-10-01" version="1" fragment="single">WLRSQETASTNVIWPRPQIWQFQTRLLTRTVLSKYSLKSRIKRRKERNQKRTTGEHIQWNSPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMB0</accession>
    <name>A0A074ZMB0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168070.1">
        <property type="nucleotide sequence ID" value="XM_009169806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMB0"/>
    <dbReference type="GeneID" id="20319120"/>
    <dbReference type="KEGG" id="ovi:T265_04938"/>
    <dbReference type="CTD" id="20319120"/>
    <dbReference type="OrthoDB" id="6258883at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="648" mass="72984" checksum="250D720925A5841E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNW5</accession>
    <name>A0A074ZNW5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPI ethanolamine phosphate transferase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596691">
        <property type="protein sequence ID" value="KER28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167420.1">
        <property type="nucleotide sequence ID" value="XM_009169156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNW5"/>
    <dbReference type="STRING" id="6198.A0A074ZNW5"/>
    <dbReference type="GeneID" id="20318593"/>
    <dbReference type="KEGG" id="ovi:T265_04411"/>
    <dbReference type="CTD" id="20318593"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="993" mass="112195" checksum="420DDF2E5F50F7EB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQA2</accession>
    <name>A0A074ZQA2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MIZ/SP-RING zinc finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_05050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168225.1">
        <property type="nucleotide sequence ID" value="XM_009169961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQA2"/>
    <dbReference type="STRING" id="6198.A0A074ZQA2"/>
    <dbReference type="GeneID" id="20319232"/>
    <dbReference type="KEGG" id="ovi:T265_05050"/>
    <dbReference type="CTD" id="20319232"/>
    <dbReference type="OrthoDB" id="10263264at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="200"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="534"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="881"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118805" checksum="5C5AB3ECA8E12A45" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQH5</accession>
    <name>A0A074ZQH5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168141.1">
        <property type="nucleotide sequence ID" value="XM_009169877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQH5"/>
    <dbReference type="GeneID" id="20319169"/>
    <dbReference type="KEGG" id="ovi:T265_04987"/>
    <dbReference type="CTD" id="20319169"/>
    <dbReference type="OrthoDB" id="10282555at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11240" checksum="EC5478A0253F0207" modified="2014-10-01" version="1">MHVFGEALQHKSTGANMHFVMTDSHSREYKVIFLLSCDQNLHSEDHISTQPVCLAVAEQKARIRNQTSETETTIRPISENFKLDANHEDTVGSGSGFDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQY1</accession>
    <name>A0A074ZQY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168045.1">
        <property type="nucleotide sequence ID" value="XM_009169781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQY1"/>
    <dbReference type="STRING" id="6198.A0A074ZQY1"/>
    <dbReference type="GeneID" id="20327793"/>
    <dbReference type="KEGG" id="ovi:T265_13626"/>
    <dbReference type="CTD" id="20327793"/>
    <dbReference type="OrthoDB" id="202764at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034128">
        <property type="term" value="P:negative regulation of MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER28212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="283" mass="31375" checksum="8D0003C7A540C342" modified="2014-10-01" version="1" fragment="single">ILRIADVTDLSKEDVSEPVPRLHVRNVSEGQSESIHPINLSELTCPARTFRQHGIYSSLLAGSRKSRSDDTLYAEFLAALEPLLQKMKELNLGRSGTLSELISELTFACRSKAVPTLRHAALNLVNLTVFGDVGAQLDVIVIWLSTLALHLDVVVQYFALLSTAFLLTKLEFTTPVLNSGIVDRIRPFVRTHSSPAEFARNSLIRAFLCVCRAQHSTAPTQCFHCYTKATRGWLQHLLPALSSPYSEVRILAAFHFSANASLNPAYLASAHIWANKYSYVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRI7</accession>
    <name>A0A074ZRI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170313.1">
        <property type="nucleotide sequence ID" value="XM_009172049.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZRI7"/>
    <dbReference type="GeneID" id="20320894"/>
    <dbReference type="KEGG" id="ovi:T265_06715"/>
    <dbReference type="CTD" id="20320894"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1381" mass="153063" checksum="A5333211FA7A27F4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRJ6</accession>
    <name>A0A074ZRJ6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166564.1">
        <property type="nucleotide sequence ID" value="XM_009168300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRJ6"/>
    <dbReference type="STRING" id="6198.A0A074ZRJ6"/>
    <dbReference type="GeneID" id="20327476"/>
    <dbReference type="KEGG" id="ovi:T265_13309"/>
    <dbReference type="CTD" id="20327476"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF67">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115905" checksum="D2D193BE30001451" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRN4</accession>
    <name>A0A074ZRN4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166464.1">
        <property type="nucleotide sequence ID" value="XM_009168200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRN4"/>
    <dbReference type="GeneID" id="20317845"/>
    <dbReference type="KEGG" id="ovi:T265_03658"/>
    <dbReference type="CTD" id="20317845"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="17955" checksum="DBB0ADF158E3DE31" modified="2014-10-01" version="1">MTGQSGNRCQLTVDRRTSQCDRKRFITNRADINAASRNSEAVRPIRQWAWDEVAWCSTFNCLRTSQTRDSAGFRRNTLICKLIWFFERLTWNPADVLRQPNVLHQAASCFSCYDIRDIAIHVYLCNVLLISLLKIRRQPTTGFTFFGAHQRGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSA2</accession>
    <name>A0A074ZSA2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167584.1">
        <property type="nucleotide sequence ID" value="XM_009169320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSA2"/>
    <dbReference type="GeneID" id="20318738"/>
    <dbReference type="KEGG" id="ovi:T265_04556"/>
    <dbReference type="CTD" id="20318738"/>
    <dbReference type="OrthoDB" id="6276395at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="603" mass="69134" checksum="E880A5F3FE96A984" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSG2</accession>
    <name>A0A074ZSG2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169965.1">
        <property type="nucleotide sequence ID" value="XM_009171701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSG2"/>
    <dbReference type="STRING" id="6198.A0A074ZSG2"/>
    <dbReference type="GeneID" id="20328197"/>
    <dbReference type="KEGG" id="ovi:T265_14031"/>
    <dbReference type="CTD" id="20328197"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14672">
        <property type="entry name" value="UBA_ceTYDP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="101"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER26300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="394" mass="44547" checksum="878043D4D434AD1F" modified="2014-10-01" version="1">MARRDHLVPMEVDPASSGDGDDLMKRCSEFSQVTHTDNAMAMMYLQDREWNLEKALSDYFREHGGPSNPVMRAYVDLTESDDQSELDKSVVFQQSNILNVLSWNIDGLDKTNFHVRLKAILSCLKSELPDIVCLQEVVLDSLDALRTQLAEDYHIFSATDDSHADCIHYFVVLLVRKCPGLSVDLSSFAVTPFFGSQMGRHTVAVDVLLDRARWSAKDVTHPPICENNNQPSPPPLRLRVITAHLESCRDGCKQRKSQLKQVWANMLQLSTNSNVDLSQTRVASIFCGDLNLRDSEVSQLGGLPVGLQDVWEQTGARPELKCTWDPVRNSNAGRFSKYVPAKHPQSHRYDRMYFCSGGYLKPIDFGLRGLERIQKHTCFPSDHWGILGRFVIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSK4</accession>
    <name>A0A074ZSK4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAD50-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596691">
        <property type="protein sequence ID" value="KER28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167449.1">
        <property type="nucleotide sequence ID" value="XM_009169185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSK4"/>
    <dbReference type="STRING" id="6198.A0A074ZSK4"/>
    <dbReference type="GeneID" id="20327676"/>
    <dbReference type="KEGG" id="ovi:T265_13509"/>
    <dbReference type="CTD" id="20327676"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="105733" checksum="93132078F3CAAD57" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSX5</accession>
    <name>A0A074ZSX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166060.1">
        <property type="nucleotide sequence ID" value="XM_009167796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSX5"/>
    <dbReference type="GeneID" id="20317522"/>
    <dbReference type="KEGG" id="ovi:T265_03335"/>
    <dbReference type="CTD" id="20317522"/>
    <dbReference type="OrthoDB" id="6244748at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13841" checksum="46316559288840AB" modified="2014-10-01" version="1">MARRIRVNQEPYNGFLLPSQIPQLNPVNTYYTTDSRCKRYFCAVCGDCHPVNTDCTQRITEWLTGTTLPDALHRSLEANIIDSYTQMRFQKAKQVEKSACDIVYMESERRKNEANALSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT76</accession>
    <name>A0A074ZT76_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165958.1">
        <property type="nucleotide sequence ID" value="XM_009167694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT76"/>
    <dbReference type="STRING" id="6198.A0A074ZT76"/>
    <dbReference type="GeneID" id="20317448"/>
    <dbReference type="KEGG" id="ovi:T265_03261"/>
    <dbReference type="CTD" id="20317448"/>
    <dbReference type="OrthoDB" id="6237182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="863" mass="96448" checksum="1D6035A11B35FAB0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTA8</accession>
    <name>A0A074ZTA8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600647">
        <property type="protein sequence ID" value="KER18494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177759.1">
        <property type="nucleotide sequence ID" value="XM_009179495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTA8"/>
    <dbReference type="STRING" id="6198.A0A074ZTA8"/>
    <dbReference type="GeneID" id="20330184"/>
    <dbReference type="KEGG" id="ovi:T265_16019"/>
    <dbReference type="CTD" id="20330184"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="15986" checksum="A8EEAFA1D3D0213F" modified="2014-10-01" version="1" fragment="single">ATPKLSENRSTNVTQRTPRKAAAFDQAAGLRSNKTSTTLIKNRSDRKRHSKPSNKSSVKFSKVHSSESLSLRGSGEFVTPAEEFCNQRTRSFSHCSISGYQHGLVVGSPNSQQFIEQNMQANAAPDVGWTSFSSSAIQPKQRPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTF2</accession>
    <name>A0A074ZTF2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600107">
        <property type="protein sequence ID" value="KER18534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177719.1">
        <property type="nucleotide sequence ID" value="XM_009179455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTF2"/>
    <dbReference type="STRING" id="6198.A0A074ZTF2"/>
    <dbReference type="GeneID" id="20330162"/>
    <dbReference type="KEGG" id="ovi:T265_15997"/>
    <dbReference type="CTD" id="20330162"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER18534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7532" checksum="9D0123262722C0FA" modified="2014-10-01" version="1" fragment="single">CSSQFIVDYYGAFYVDKTISICMEYMDAGGLDTLLPTVGRFPEPIIVLIADSVTQGLLFLWQELHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTF7</accession>
    <name>A0A074ZTF7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169604.1">
        <property type="nucleotide sequence ID" value="XM_009171340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTF7"/>
    <dbReference type="GeneID" id="20320329"/>
    <dbReference type="KEGG" id="ovi:T265_06147"/>
    <dbReference type="CTD" id="20320329"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6980" checksum="4D50860838F871CB" modified="2014-10-01" version="1">MSGIRTLELPDRRNEDTIQFYPLHTFWNNSPVPCVQITPAGSSIRPTDKNPLQQKFCIPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTK4</accession>
    <name>A0A074ZTK4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165735.1">
        <property type="nucleotide sequence ID" value="XM_009167471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTK4"/>
    <dbReference type="GeneID" id="20317253"/>
    <dbReference type="KEGG" id="ovi:T265_03066"/>
    <dbReference type="CTD" id="20317253"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6792" checksum="9CB7B11A758F9FE2" modified="2014-10-01" version="1">MTATSVLALMLHCRTTIKLTSSHIAGNFARGTAPPGAFKHLILGRKLALLKSLRNIPANPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU02</accession>
    <name>A0A074ZU02_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169344.1">
        <property type="nucleotide sequence ID" value="XM_009171080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU02"/>
    <dbReference type="STRING" id="6198.A0A074ZU02"/>
    <dbReference type="GeneID" id="20320115"/>
    <dbReference type="KEGG" id="ovi:T265_05933"/>
    <dbReference type="CTD" id="20320115"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="28992" checksum="88BAED5C10A61787" modified="2014-10-01" version="1">MPCFQCGRKFGFAAKEVACRSCNRIFCSKCVKYKVVLPEHGNKQCEVCFSCYDKATNPDQPVAPKLEPPKILLDRMEALGISSSGVPSSVPGACGGGGCAVRNRSHSPAVPHIGELELRLDALRDVPKPDEVPSHEELQERLRKLRESDHVQQNISNPVKSDKVSNLIDQVHAERNIDGGATVNLDGSDEGELPWCCICNKNAQVCCVDCDGDLFCKACYRTFPPSVRSRNCYLCIVRRSHRSGEEKHHQWEPFAPSRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV75</accession>
    <name>A0A074ZV75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597340">
        <property type="protein sequence ID" value="KER19089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177165.1">
        <property type="nucleotide sequence ID" value="XM_009178901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV75"/>
    <dbReference type="GeneID" id="20326182"/>
    <dbReference type="KEGG" id="ovi:T265_12014"/>
    <dbReference type="CTD" id="20326182"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="8123" checksum="CA8C04F215041A21" modified="2014-10-01" version="1">MQFIIQKEFEYITKKNEEEIPTSPIRLQDHWVSSKSLSMIDARKVIPTGNEYDSARKSLKRLRKDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVJ2</accession>
    <name>A0A074ZVJ2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_02264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164732.1">
        <property type="nucleotide sequence ID" value="XM_009166468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVJ2"/>
    <dbReference type="STRING" id="6198.A0A074ZVJ2"/>
    <dbReference type="GeneID" id="20316452"/>
    <dbReference type="KEGG" id="ovi:T265_02264"/>
    <dbReference type="CTD" id="20316452"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="477"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="927" mass="102264" checksum="BB9931C537D87401" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVM3</accession>
    <name>A0A074ZVM3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166306.1">
        <property type="nucleotide sequence ID" value="XM_009168042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVM3"/>
    <dbReference type="STRING" id="6198.A0A074ZVM3"/>
    <dbReference type="GeneID" id="20317717"/>
    <dbReference type="KEGG" id="ovi:T265_03530"/>
    <dbReference type="CTD" id="20317717"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="190"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="393" mass="43997" checksum="4630A87FCCF89BFF" modified="2014-10-01" version="1">MSLFFFSDTGTWVPESCIFGQLLNMAATLSRTAALPGSRRAVPAGPEHKLVRMFIRCQSKVRMRANPRKTEKMEEVHKARNALRLFHLTRISTRWKRPGSETIKDRSSVTIVNRGRPDRSAENFEQQCTWPSAVIHPEPTVEVQSWTMNLEFPAAAKVDGCICSLNLSQVLGSDGLPTLFNDKDGVLSAVSAYLWYKQANARLLVGLRPLMRCRCRTALGFGLLSSLGISLVANFQSALALNRQSNPFSCLLPQFQETAVWAVHLTGAALLYCCGLVYFAIVTNVSHHYLDSKQWALRVVLCTCATISAFILPVAGTVARFMYDGKNIRKWTPEDRGYVYHAISSFAEWMLAICCLGFSLTMVAELKDYSILAVKLKHHRTRHSRDSTLTLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXM2</accession>
    <name>A0A074ZXM2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168160.1">
        <property type="nucleotide sequence ID" value="XM_009169896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXM2"/>
    <dbReference type="GeneID" id="20319188"/>
    <dbReference type="KEGG" id="ovi:T265_05006"/>
    <dbReference type="CTD" id="20319188"/>
    <dbReference type="OrthoDB" id="10445454at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9630" checksum="304A2288FD171AC4" modified="2014-10-01" version="1">MLTWNLAEYLVRDVSRQLNVLYQTASCFNCHKYTHLQINLVFTRDPTESLVYDILQLKVLHTGRLMFQLARYLRYRSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYN8</accession>
    <name>A0A074ZYN8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165100.1">
        <property type="nucleotide sequence ID" value="XM_009166836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYN8"/>
    <dbReference type="STRING" id="6198.A0A074ZYN8"/>
    <dbReference type="GeneID" id="20316745"/>
    <dbReference type="KEGG" id="ovi:T265_02557"/>
    <dbReference type="CTD" id="20316745"/>
    <dbReference type="OrthoDB" id="6314747at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="164" mass="18345" checksum="7823DEBD8323B146" modified="2014-10-01" version="1">MSQQSAEAQAAYSVVKNFVRCWLGPNPLKMSPRMVTKRLQTNCQARRTDQQPPDQSPTNTTELPIFQHITRENNSHTKAIRGKPVVGCRRIFGSLVSSVLCLFTSPWTQPRTDDVTSIGDETFAIQLPGSVNTPTTRQRTRATHILQDCQQPRIGGLALIQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYT6</accession>
    <name>A0A074ZYT6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sphingomyelin phosphodiesterase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175905.1">
        <property type="nucleotide sequence ID" value="XM_009177641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYT6"/>
    <dbReference type="STRING" id="6198.A0A074ZYT6"/>
    <dbReference type="GeneID" id="20325250"/>
    <dbReference type="KEGG" id="ovi:T265_11082"/>
    <dbReference type="CTD" id="20325250"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704442" description="Sphingomyelin phosphodiesterase C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="5">
        <location>
            <begin position="298"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="499" mass="56389" checksum="13D7A21DEB4B9719" modified="2014-10-01" version="1">MKGVVLLRCLFVVLFLGFRATSRNVGTFWHFTDFHVNMSYGILNSSGSWGRYDQDTSPIVAFTGIELGNDYGYAENKPDFVIWGGGSAPQGGAATARDLRESLAFLSLHFRNAFPTDQIPIIPVIGTHDIYPPNKMSPKLHDSDRTKWCTELATNESLWKPWILGGFETKESIFHRNCYMLYTIPNKKPLIVLGLNSLVWYTNNSLVDERIVDPLNQFQWIMDNLEYARKNAIKVILAMHVPFGGPEIGANDYHHLKETYNEMLVELIRNYSSVIITTIASHEHIDAFRVILDEKYHPVGTMFLGPAVTPRHIDGIGSNNPRIRQFFYDRDTGAVLNYRQFYLNLTQDGPSWKVEYNATGEYSLNNLTATELGKLLDEFTTEDDKNGRWGAYWKHQLGGRPHEKPPKRGDGECPEARSVCRCEQICSIRHLDVKTLNECLKICQSSDTPHLNTIDDLINGRGGSDVSNAGTIVGIVIGVLLLAGVLIGIGFILYRRWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZL7</accession>
    <name>A0A074ZZL7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596693">
        <property type="protein sequence ID" value="KER28710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167518.1">
        <property type="nucleotide sequence ID" value="XM_009169254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZL7"/>
    <dbReference type="GeneID" id="20318681"/>
    <dbReference type="KEGG" id="ovi:T265_04499"/>
    <dbReference type="CTD" id="20318681"/>
    <dbReference type="OrthoDB" id="6248473at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="715" mass="79398" checksum="1F86310F1DD250B7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZY1</accession>
    <name>A0A074ZZY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163310.1">
        <property type="nucleotide sequence ID" value="XM_009165046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZY1"/>
    <dbReference type="GeneID" id="20315291"/>
    <dbReference type="KEGG" id="ovi:T265_01103"/>
    <dbReference type="CTD" id="20315291"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="206" mass="23619" checksum="479779BE0E352661" modified="2014-10-01" version="1">MCAFCPKVHPTLEYYEYLQHSLQADQSNRTHGRPVLMRRNTRSSKYDPLIERSSTHMSDALTVSLRHLAPSADFGCAPASEQQQPESNADSFIKPELSDSASESEMSNSSEHPLVIQQQRTRPALTRVPSNVAVSRKLILRGRQLRYETDRQQSRVSRIVEEVRGPPNSVSTKRDLLLTIILQIDTSHWTDYTVRPTLHRIPHHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0A1</accession>
    <name>A0A075A0A1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163224.1">
        <property type="nucleotide sequence ID" value="XM_009164960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0A1"/>
    <dbReference type="GeneID" id="20326865"/>
    <dbReference type="KEGG" id="ovi:T265_12697"/>
    <dbReference type="CTD" id="20326865"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="58" mass="6293" checksum="C80F6BF2C9810238" modified="2014-10-01" version="1" fragment="single">RLGAAHSVASKHRKRKIQLGSRHQNAFTSISSNPVKVLLDAKHGICPPDDKLGPFHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0T1</accession>
    <name>A0A075A0T1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596685">
        <property type="protein sequence ID" value="KER29130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167160.1">
        <property type="nucleotide sequence ID" value="XM_009168896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0T1"/>
    <dbReference type="STRING" id="6198.A0A075A0T1"/>
    <dbReference type="GeneID" id="20318400"/>
    <dbReference type="KEGG" id="ovi:T265_04214"/>
    <dbReference type="CTD" id="20318400"/>
    <dbReference type="OrthoDB" id="6283219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="280" mass="31786" checksum="3B1A54C10C1A1A42" modified="2014-10-01" version="1">MSQSDDGLRPPVLSRNASPTERDAVHSSDNLHMELELARVRIRELEIQLELQKLSEAKAKRNNQDECDSHTQLQSDPADSKSIAFALERRLELPKRELQRFSGNPKDYWAFMKAFSSTIEDRTRDDEARLGYLIQYCDGEAKRRIEHCTVLRPNEGYGLAKEILRKRFGQNYMVARAFIDDLITGPTIKDGDSSALSDLAQQLTVCEVTLREMDYSSDLNSQHTIQTIVRRLLLDFVSNGPKLSLTSDEKIVSQKLLTLLPLSKHVLIACVRITANLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Z5</accession>
    <name>A0A075A0Z5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164257.1">
        <property type="nucleotide sequence ID" value="XM_009165993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Z5"/>
    <dbReference type="STRING" id="6198.A0A075A0Z5"/>
    <dbReference type="GeneID" id="20316055"/>
    <dbReference type="KEGG" id="ovi:T265_01867"/>
    <dbReference type="CTD" id="20316055"/>
    <dbReference type="OrthoDB" id="10354254at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="259" mass="28804" checksum="4F411167A12A4159" modified="2014-10-01" version="1">MVGVLTCLMGVLGILLARRYRQQYQQRHVSRNRNEKRPCPTRPNSLGIAPNGSLARSSKCGRMINSSSSSDKCSSLLGRNNHLWLNLHTYSNPLVTTNLMQHDRPMTGNSGPGSVLCSCVEAGQIFDPDNGSHVLTSCRDGTIYRSLVRNNNTIRKTEPGSLLRPQDFGEVTRCPPVPLTFPIEDSIILGGKPRNPLPQTFMPLHPQPTWMHTETNATHKPEMELRISENRLTPTYVSALRVDSNPASQFDPLNIDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A279</accession>
    <name>A0A075A279_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162680.1">
        <property type="nucleotide sequence ID" value="XM_009164416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A279"/>
    <dbReference type="GeneID" id="20314776"/>
    <dbReference type="KEGG" id="ovi:T265_00588"/>
    <dbReference type="CTD" id="20314776"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="201" mass="22476" checksum="14E962E069220BE1" modified="2014-10-01" version="1">MGTCKKSCHVIQQHSNIMQYEQLNFLNEWLCENAPRKHAHKTECFRPSRHLGPSKALALTVRTATQQYQSCCSHATFPSNVKERKPSAVALFRCLAAMPPEGSTRVGILPGCPSLDRGSRVAEVGFEPRAFRSVNSRSNHLGHLAPFQCGNIFIQTFSPACIKQQFSQEKTFSRGDIYVLVPGRVEIHNHQLEQSTIGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2A9</accession>
    <name>A0A075A2A9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596959">
        <property type="protein sequence ID" value="KER21534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174711.1">
        <property type="nucleotide sequence ID" value="XM_009176447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2A9"/>
    <dbReference type="GeneID" id="20329233"/>
    <dbReference type="KEGG" id="ovi:T265_15067"/>
    <dbReference type="CTD" id="20329233"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="145" mass="15364" checksum="79110C43C40F4EDF" modified="2014-10-01" version="1" fragment="single">AVGGIKIVHPGFTDSRIDTQDRGFCPGSPGRFCSCRLAAVVHLKGTSEKRVQHRSLCSQRGAGEKQPLLCSCGSLFLSDNPKRTGSLSIFITVDVGTINASLGHICHTAMCLTAAGERQPLTDKNKSDPGNLGNSLDPVYQSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2D9</accession>
    <name>A0A075A2D9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162738.1">
        <property type="nucleotide sequence ID" value="XM_009164474.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A2D9"/>
    <dbReference type="GeneID" id="20314834"/>
    <dbReference type="KEGG" id="ovi:T265_00646"/>
    <dbReference type="CTD" id="20314834"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1290" mass="143352" checksum="9C4DD10B2653E43C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Y5</accession>
    <name>A0A075A2Y5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596669">
        <property type="protein sequence ID" value="KER29945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166308.1">
        <property type="nucleotide sequence ID" value="XM_009168044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Y5"/>
    <dbReference type="GeneID" id="20317719"/>
    <dbReference type="KEGG" id="ovi:T265_03532"/>
    <dbReference type="CTD" id="20317719"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="9699" checksum="CE33BC9AB0499190" modified="2014-10-01" version="1">MVATINSYTREPHGALKQAGSRTEKAVTTDKHARSNFVAGQLYPTDQTCALYEAKTWRFTAQQRNDSPSVWCGHVIKPVVKVAEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3I7</accession>
    <name>A0A075A3I7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163424.1">
        <property type="nucleotide sequence ID" value="XM_009165160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3I7"/>
    <dbReference type="GeneID" id="20326888"/>
    <dbReference type="KEGG" id="ovi:T265_12720"/>
    <dbReference type="CTD" id="20326888"/>
    <dbReference type="OrthoDB" id="6248600at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9750" checksum="D6585F9BD6A64C9B" modified="2014-10-01" version="1" fragment="single">MLRLLSTAPLLQASKRNFQLHFHEATIAPKRTRMFLFLVTAVALPSNVWAFFFVFRREHERKEREKIEGPSYVRKMPRYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A480</accession>
    <name>A0A075A480_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163170.1">
        <property type="nucleotide sequence ID" value="XM_009164906.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A480"/>
    <dbReference type="GeneID" id="20315179"/>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53494" checksum="2919BC3D55006F1F" modified="2014-10-01" version="1" fragment="single">MTSDTKSGEFAMTEYTTVKAGYELLNKKYRRNHREMDKGVSALNKSLDELESATDITKAVELLNKVVNVVSGSKRKADSVYAEELKLLLASKRRIEHITQVSVLDKKLSTTDTSSGTQELVKKSLLRADPASGLFNSSEQALFLTRFQRHLADYLFTCGYPKAALKLANENPDLKELCLTELFEEAVLIEDALARGDTGPAHSWLQEANFKLKKNESVFEFDLRVFEFYLLVREGKRMEAIQHARKYMSSIKKPDEYKATKLGQAMVLLAMRTPEELQAKAEYNNLTEKWIVKRAHEVLMDFYSYPAYSPFQLIVNAGISVIKTHQCYDSKSQHRDCAVCHPLINQLAVPLPFGRHDHSVLTCYQTGLPMNEHNLPMSLPNGYVYSEKGIAELTGPDGMVTCPRSGKRFKTSEVQRVFILYIIILRLAVAFLPQPNMQSTHAQLGEARFGPSRLTMALICQCIAKALFASCSASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A523</accession>
    <name>A0A075A523_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596893">
        <property type="protein sequence ID" value="KER22529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173706.1">
        <property type="nucleotide sequence ID" value="XM_009175442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A523"/>
    <dbReference type="STRING" id="6198.A0A075A523"/>
    <dbReference type="GeneID" id="20323564"/>
    <dbReference type="KEGG" id="ovi:T265_09395"/>
    <dbReference type="CTD" id="20323564"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="441" mass="47940" checksum="1758DF408E62CC86" modified="2014-10-01" version="1">MADVLLTHGRRHLVCGEIAQAVESFQKACELIATEHGDLDDRLAEPNFLYGSALLELARMESTVIGNALVGVPEEDSASESDDLVETGPQMTAEEQEELSNQVLDAMCEPSVDEAADNVNGDAPTEEGAECAPEDEAEEKASSDGDVEEEVESASNNEEQAETAEDEVDADTQEDISNLQLAWEVLEVSKTIYSRRTDTESRLKVADCLEKLAEISREKEDYVQALSDLQDCLTIRSAVLNDDHRDIAEVHYQLGTTHAIAGALDVASTCFRNAVSCLQQHANNIRTKITEMEKLDDQVVELEALRNSLKEVESLVCDVQRRHAEVNEDLAATQPGITSSSSTSAAKSTESDTNVQVVDDISHLVRKKRAVSDETAAEPTVSEITPIPNETQKLKKARITTDNPDTNGDVEHLNGTSQTTLTNGTQVTCTQFPPTTHSTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A551</accession>
    <name>A0A075A551_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162844.1">
        <property type="nucleotide sequence ID" value="XM_009164580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A551"/>
    <dbReference type="GeneID" id="20314919"/>
    <dbReference type="KEGG" id="ovi:T265_00731"/>
    <dbReference type="CTD" id="20314919"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7403" checksum="44DAE5FACE5AB309" modified="2014-10-01" version="1">MEQLYRAPRSLNLDLLRFETKSQLPVLASVLPDKNHPEYRKKTKQSLVLERLSCFVSNNDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5W8</accession>
    <name>A0A075A5W8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165264.1">
        <property type="nucleotide sequence ID" value="XM_009167000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5W8"/>
    <dbReference type="STRING" id="6198.A0A075A5W8"/>
    <dbReference type="GeneID" id="20316886"/>
    <dbReference type="KEGG" id="ovi:T265_02698"/>
    <dbReference type="CTD" id="20316886"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10729" checksum="3873D7C0054AB954" modified="2014-10-01" version="1">MERYAKSPPRIEGMVSLKVDNLAYRTTIEDLRRVFSRYGEVDVPGLHDEMEDVRGRFLLGVIAGLHARSCFAGVECIVCSLTTSVRGMHELKCGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A686</accession>
    <name>A0A075A686_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162308.1">
        <property type="nucleotide sequence ID" value="XM_009164044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A686"/>
    <dbReference type="GeneID" id="20314487"/>
    <dbReference type="KEGG" id="ovi:T265_00299"/>
    <dbReference type="CTD" id="20314487"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33546" checksum="F3BB72D237E458F9" modified="2014-10-01" version="1">MKKHSRKQNKAQDGRPAATVASLRIKIRCPKDFGLPYGKHYSPSLHGECADKRFETISSLVGLPEPTAITSGHRRQFDCKRFITNRGDIISALLWSVVVRSGSTTTNPPLRTTTLHNNALMMSPRLVMKRLQSNCPAQRTSQRPPYLRKPIIEMNLCPGARHKRKNKENCKKSFIRSTISVPNCHAIGMKHEDWDTAKFPKPTQGKSRDRGRVRTTDFPVSKFELWPLSCLVSRQTENKTNKHWLITPNINLQSTHYESYVRPRNVVYTSYQLQTYNQKDGQDTNSFVRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8W2</accession>
    <name>A0A075A8W2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596829">
        <property type="protein sequence ID" value="KER23949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172327.1">
        <property type="nucleotide sequence ID" value="XM_009174063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8W2"/>
    <dbReference type="STRING" id="6198.A0A075A8W2"/>
    <dbReference type="GeneID" id="20322486"/>
    <dbReference type="KEGG" id="ovi:T265_08307"/>
    <dbReference type="CTD" id="20322486"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="227" mass="24903" checksum="A8EEB161010941B9" modified="2014-10-01" version="1">MHLVYKTEYPSSPSTRLPEPSWIFIDCYSIASKRYIATPQIPDAKRIYEKTYYSHAPTSSITVTPSRACPISHQPPVPYPPLPQNFTVSSLAHPNPVQYSCSLPSSPNVVILPPLMFLPRIISPYIPVAASQSMVTSCFLVQSDPAVRVPCAVNSTVTDALVTPIPTALREPSQTATSSNIRSTPPISRPAERNMIAILPKEPPLVNLQTPAEALSIRTMELNSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9Y2</accession>
    <name>A0A075A9Y2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163727.1">
        <property type="nucleotide sequence ID" value="XM_009165463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9Y2"/>
    <dbReference type="STRING" id="6198.A0A075A9Y2"/>
    <dbReference type="GeneID" id="20315625"/>
    <dbReference type="KEGG" id="ovi:T265_01437"/>
    <dbReference type="CTD" id="20315625"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="37399" checksum="9E27FEE978B57B33" modified="2014-10-01" version="1">MSKRGGLGEVLDEDRQKPLKISKPSLDSDEEDYQESECFRLREADIDGQENATLEYDDGIKITPFNMREELEEDGYFDGNGNFVFKKSVDARDNWLEDIDWAEVNRNQTTKKMTDTSISDDPPTVPVVNERKTEMYQELLRFLLPKETVLRSIKRMGAQSNSANSSSASQRWLKKKQKTTTQENPVTELADQLLQAGEFDVYQLSRESIERIVNKASETGMDDELEALGQAFDKSTEDYNKPASTDNSTRDNPENGSQPEDSEVTWHLKYSDSLDSPPEGPYTTKQLRAWVEAGKYKDKPIVLVRQANKPDGQFYNIRRIDFDLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAA0</accession>
    <name>A0A075AAA0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596808">
        <property type="protein sequence ID" value="KER24499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171766.1">
        <property type="nucleotide sequence ID" value="XM_009173502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAA0"/>
    <dbReference type="GeneID" id="20322041"/>
    <dbReference type="KEGG" id="ovi:T265_07862"/>
    <dbReference type="CTD" id="20322041"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11477" checksum="A876FDE242D63293" modified="2014-10-01" version="1">MDGAHTNTPWCNATGCPSLQRVPDCHTRFSPLAHATRFAESTSHLHPLDLTFLEEMMALISMPFIKRDLFALRECRTTVVDVNIPPDGRQMLVWNERRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAG3</accession>
    <name>A0A075AAG3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163537.1">
        <property type="nucleotide sequence ID" value="XM_009165273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAG3"/>
    <dbReference type="GeneID" id="20326918"/>
    <dbReference type="KEGG" id="ovi:T265_12750"/>
    <dbReference type="CTD" id="20326918"/>
    <dbReference type="OrthoDB" id="6256958at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="56983" checksum="AD7543EB9B348539" modified="2014-10-01" version="1" fragment="single">MSGPELMQEQPRIGGADYYSRLKVENEFRNQGQKRVFANEVQRRFNRHKNEQENKLDERRRKLLTVLQCEGYMYEELCRENLRQEQKKIKANLFAEAERLKGELLEKERQIAEEKNLCRSELPDLQALHKAHLREIMRDRETIARMVERDKMEQERLDQLVGIGPTLLKEQLEREEQAKQERQYKLRELAEGHLREAEARKRGILQEKQTEREEGLRFLEKLKTEDEREHGAYDDRVRKQAELLHLAQSDLVESRKRRERERYLGELVDAYCNPFLEMARGRDVLKEKERLRKEQLQFMEYQKQVTKDEECFDKHTDRLYAEIARRKEAKERERMRKARERATEEAKQVVEHHRKRFAEKAAAQKAATHEQKEIAEVIKRDHEQYVEQVKREKQERLDRNREFLEASKVHAEQTNQLRRKLTREEMEREREVMFRTECEYRRRLALLAADNPTLRHLHPWRKHAMANNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAY9</accession>
    <name>A0A075AAY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IRS-type PTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596799">
        <property type="protein sequence ID" value="KER24739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171532.1">
        <property type="nucleotide sequence ID" value="XM_009173268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAY9"/>
    <dbReference type="STRING" id="6198.A0A075AAY9"/>
    <dbReference type="GeneID" id="20321868"/>
    <dbReference type="KEGG" id="ovi:T265_07689"/>
    <dbReference type="CTD" id="20321868"/>
    <dbReference type="OrthoDB" id="6238113at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF62">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="143"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="591" mass="67056" checksum="5C74ED62F5319675" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABZ0</accession>
    <name>A0A075ABZ0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596785">
        <property type="protein sequence ID" value="KER25164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171082.1">
        <property type="nucleotide sequence ID" value="XM_009172818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABZ0"/>
    <dbReference type="GeneID" id="20321505"/>
    <dbReference type="KEGG" id="ovi:T265_07326"/>
    <dbReference type="CTD" id="20321505"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="6779" checksum="F5DA7B7761422807" modified="2014-10-01" version="1">MLTDPADPVDDGEDNCFPVVRELANAAAAFAAEAEAAATISVLGRNRRSGNQFTESQLVMPEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC63</accession>
    <name>A0A075AC63_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170958.1">
        <property type="nucleotide sequence ID" value="XM_009172694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC63"/>
    <dbReference type="STRING" id="6198.A0A075AC63"/>
    <dbReference type="GeneID" id="20321408"/>
    <dbReference type="KEGG" id="ovi:T265_07229"/>
    <dbReference type="CTD" id="20321408"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="27557" checksum="856A773AAD936AA5" modified="2014-10-01" version="1">MKETTHKVAGNSSTAHDRFRPSWGSSGRHSRRVSVNLTIYLNSNWTDCDKSKHLQISLVFHGRLKVAENSSTAHDRFCPSWAHQVGAVPEFLSSSCFTFSFFSLSFRNDLWCQRRHHQIECKTGYVYRCLKRLKHAAAWCSIFSGLRTSQTKDSARFQLNKFRSKIAFPATIQYGKGFSESRNFQPEARRKGEKCSAVEPFRCLDAMPTAGSTRVGILPGCPSLERGSREGKGICQHMRARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AC66</accession>
    <name>A0A075AC66_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170960.1">
        <property type="nucleotide sequence ID" value="XM_009172696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AC66"/>
    <dbReference type="STRING" id="6198.A0A075AC66"/>
    <dbReference type="GeneID" id="20321410"/>
    <dbReference type="KEGG" id="ovi:T265_07231"/>
    <dbReference type="CTD" id="20321410"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:L-tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42670" checksum="284176D06CBAFBC7" modified="2014-10-01" version="1">MRSPVAGKSFVCLRDAVFEILPVITKNWGHGRSPAGWFTTKLPEKFKVWNDLIDNLPELFKTGSLRSEVRALPLLHPDGLTSVDQLRFAHKILAFATSSYVWINGDEGATKSIPPQLAVPLVEVSEKLALKPVITYHDLVLTNCYYLGQEDLPKTIHQLSHHEGWKPYIELHALVEICYSPCLDAILNAIEAQSPLNADKIIDSLEQITKVFQFMPKVLERFYGWLDPEEFMFSLKPLIWGWNIGSLKSGLLYEGVRTPDVLDDLSGTEQQKENDQRLGRRFTFTGPNGAQSIFLQATDLFLGVAHDPRDDAFFSRMRKYMTAQHNQFLEDVAKYSRIKEIVSSTDNPKLKSAYEKCLETVREYRNNHTRLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACB8</accession>
    <name>A0A075ACB8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162733.1">
        <property type="nucleotide sequence ID" value="XM_009164469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACB8"/>
    <dbReference type="STRING" id="6198.A0A075ACB8"/>
    <dbReference type="GeneID" id="20314829"/>
    <dbReference type="KEGG" id="ovi:T265_00641"/>
    <dbReference type="CTD" id="20314829"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="532" mass="60446" checksum="52188CB46CBB7E9B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADY2</accession>
    <name>A0A075ADY2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo/beta-catenin-like repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169858.1">
        <property type="nucleotide sequence ID" value="XM_009171594.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075ADY2"/>
    <dbReference type="GeneID" id="20320535"/>
    <dbReference type="KEGG" id="ovi:T265_06353"/>
    <dbReference type="CTD" id="20320535"/>
    <dbReference type="OrthoDB" id="6240098at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="108239" checksum="F353E62985728139" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFU6</accession>
    <name>A0A075AFU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168158.1">
        <property type="nucleotide sequence ID" value="XM_009169894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFU6"/>
    <dbReference type="GeneID" id="20319186"/>
    <dbReference type="KEGG" id="ovi:T265_05004"/>
    <dbReference type="CTD" id="20319186"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="11040" checksum="5ED0723F55E47A4E" modified="2014-10-01" version="1">MRRSGAAHSTAGKHHKREIQLGSRKTRRPLELLFWRLLTAIESNSPVALELWTVNLEPLLASKAYEYIFSPKCHYALGPDDHLPRCTGMGSSVNEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHL5</accession>
    <name>A0A075AHL5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166205.1">
        <property type="nucleotide sequence ID" value="XM_009167941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHL5"/>
    <dbReference type="GeneID" id="20317644"/>
    <dbReference type="KEGG" id="ovi:T265_03457"/>
    <dbReference type="CTD" id="20317644"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13137" checksum="31FFCCD5F8203959" modified="2014-10-01" version="1">MERKDGKEGQDIYVTGLRPRLEIRWFVRSLMPLQDGQSFVKGGWLASGEITIKEVVAVNLPWKWFTQVGLQYFADELPLILKGYVDEEIIQVGADSDLVSTKKQLLGHTQMDIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHN0</accession>
    <name>A0A075AHN0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166053.1">
        <property type="nucleotide sequence ID" value="XM_009167789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHN0"/>
    <dbReference type="GeneID" id="20317515"/>
    <dbReference type="KEGG" id="ovi:T265_03328"/>
    <dbReference type="CTD" id="20317515"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15261" checksum="8F8CCE7817008CFD" modified="2014-10-01" version="1">MGVLQMQQTPSKTNGKLWNPKKLLPFESPRRLLHSRTNSSVLASNAELPTPRTETNGTAAATTTVRQISHGCTAVKHLRTDDDDDDDDGMEKLRMEIKLLQKLIQNKEMGRRTMVQIIESNDQEELRRTEGCKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI14</accession>
    <name>A0A075AI14_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165365.1">
        <property type="nucleotide sequence ID" value="XM_009167101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI14"/>
    <dbReference type="GeneID" id="20316964"/>
    <dbReference type="KEGG" id="ovi:T265_02776"/>
    <dbReference type="CTD" id="20316964"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="32125" checksum="299EF80324EF2AB5" modified="2014-10-01" version="1">MNYLVEAIQSNGKIDKLPAACTLINLLVTTMNAADSLFAISSITLGAKASGDHTASVNVLGTRPLGYPFFDCTLDTAQEYFYQFAIMHQQCVSMQAVEMNNLVALLLVGHGTIKPLSTNQQYGLLTEDTAPLSFTPATSMAQILNNIVTVTEYHTKSQEIARWSKTIPFILMFLDVINSLFVAHSLSRLLMFALHGLLTGASWRFKKATKCSTFLRLLYFTDLSAMKNPQTITKITTNRFTRRLTTLAIYIQIGVIACFPVDTALESVEWGNLTFGPVYVGNKRDYPPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI61</accession>
    <name>A0A075AI61_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165198.1">
        <property type="nucleotide sequence ID" value="XM_009166934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI61"/>
    <dbReference type="GeneID" id="20316824"/>
    <dbReference type="KEGG" id="ovi:T265_02636"/>
    <dbReference type="CTD" id="20316824"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704647" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13861" checksum="B5B38FBE13CD9037" modified="2014-10-01" version="1">MCITLVRGHHRSVLHLIAFVFTGIEQCSSNEYVRNCREHVPSENHCPLVNLDTNIGRPRQFQFLLASGSRFLPIHYWLEHKFSDRKVRGSNPTSASRLSLSRLGQSGNIPDLVLLSGGMAAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI85</accession>
    <name>A0A075AI85_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596649">
        <property type="protein sequence ID" value="KER31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165045.1">
        <property type="nucleotide sequence ID" value="XM_009166781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI85"/>
    <dbReference type="STRING" id="6198.A0A075AI85"/>
    <dbReference type="GeneID" id="20316706"/>
    <dbReference type="KEGG" id="ovi:T265_02518"/>
    <dbReference type="CTD" id="20316706"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043535">
        <property type="term" value="P:regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704626" description="Reverse transcriptase domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="548" mass="61703" checksum="DD5347E9FC3FDC46" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIH7</accession>
    <name>A0A075AIH7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164598.1">
        <property type="nucleotide sequence ID" value="XM_009166334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIH7"/>
    <dbReference type="STRING" id="6198.A0A075AIH7"/>
    <dbReference type="GeneID" id="20316348"/>
    <dbReference type="KEGG" id="ovi:T265_02160"/>
    <dbReference type="CTD" id="20316348"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="16486" checksum="53DE974A90F646DC" modified="2014-10-01" version="1">MVWFCTLGGGFSSLGDNCAGAAEVAGKISLMQLRLALEIGSPVIQAKAKLWFAQSLLQRGFLRTSARLLRLVYREWKPRMSKDTPADRRIDLMAVGLWERLRHSWRCRKRHAVVSLQNDVQYVDRRPKRRYRFPDLSALLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AII6</accession>
    <name>A0A075AII6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164494.1">
        <property type="nucleotide sequence ID" value="XM_009166230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AII6"/>
    <dbReference type="GeneID" id="20316259"/>
    <dbReference type="KEGG" id="ovi:T265_02071"/>
    <dbReference type="CTD" id="20316259"/>
    <dbReference type="OrthoDB" id="6254983at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="393" mass="44652" checksum="27A672677E59F639" modified="2014-10-01" version="1">MMERFDFNYSINTSDLQLGRMALEHHHRNMASLENDPDRVNDGREFLDRPFAGIAILAGFFLLITIILCILILIFYKKRNTVFVYEKSVHRGLTTSLGDRSVVIGHASGARHLASQYAYNSEVGSTEDESTEDDSCDGWEVIQATAQSMFPSTPDYCPAHPTRAAYNIRPNDQLIANFQVLRQHYPEGSICVEVQDHIPDRHFETLNKNGAVCRSVGRRRHQLQAQNRHLPLVCEKYHFNMTKPVNQVISTFHHSVSTESEPPKLVPDIPTIQGLYGEEQWWINCIISNNICSILTNSLVDNATLRDNLRQEHATKHNADKLNRVKYSGTRWSQQESRSLLQLVTNSYILWHANCGDHEAGAVSSCSFSHQHRTQVANALLANTTAPTIIWWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIV2</accession>
    <name>A0A075AIV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164059.1">
        <property type="nucleotide sequence ID" value="XM_009165795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIV2"/>
    <dbReference type="STRING" id="6198.A0A075AIV2"/>
    <dbReference type="GeneID" id="20327002"/>
    <dbReference type="KEGG" id="ovi:T265_12834"/>
    <dbReference type="CTD" id="20327002"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="146" mass="16567" checksum="C898F99A44BB3CFA" modified="2014-10-01" version="1" fragment="single">NNIGYYGIVAIGHPPQYFKLVFDTGSPNIWVGSEQLAQHLLMSESSYYPSESVTFIDKKKTYHAVFGNYVATGRIVSDIVRFHGHQFRTDYGLVDNVQGYVDQLLTIDGLYGLMLKPTHDEIKSTPLDEMFSQGLISRRMFAFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJB2</accession>
    <name>A0A075AJB2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163156.1">
        <property type="nucleotide sequence ID" value="XM_009164892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJB2"/>
    <dbReference type="GeneID" id="20315165"/>
    <dbReference type="KEGG" id="ovi:T265_00977"/>
    <dbReference type="CTD" id="20315165"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6320" checksum="C61CA4D46197E49B" modified="2014-10-01" version="1">MADDALSPCNMDGKSGESANSPAPGGLIVHAAMSCSKVGGLEQKTCWGLYSSSSEGILNAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJF1</accession>
    <name>A0A075AJF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162915.1">
        <property type="nucleotide sequence ID" value="XM_009164651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJF1"/>
    <dbReference type="GeneID" id="20314967"/>
    <dbReference type="KEGG" id="ovi:T265_00779"/>
    <dbReference type="CTD" id="20314967"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15022" checksum="002E32EBBD53E907" modified="2014-10-01" version="1">MSFKQQYVGKQGCRSKNCPAMRTYDQKSLIHSLALPTRDIHEYLVMTKVPPGVETDVWVITVSTSTVNQRMRSPPCIPCEVTPSQLKCGAAIQTVQTVPVCQSGFYRGKMTIYAEDASKRQPEDLVHLDDPYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJI0</accession>
    <name>A0A075AJI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162841.1">
        <property type="nucleotide sequence ID" value="XM_009164577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJI0"/>
    <dbReference type="STRING" id="6198.A0A075AJI0"/>
    <dbReference type="GeneID" id="20314916"/>
    <dbReference type="KEGG" id="ovi:T265_00728"/>
    <dbReference type="CTD" id="20314916"/>
    <dbReference type="OrthoDB" id="6266412at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="26229" checksum="CAB4A473A829D7A7" modified="2014-10-01" version="1">MCVARVRANSGFFPTTLMPKPKDMVEFLLLAPTRASKSTSTVFSESPWTIRQSVICVASDAREFEFGTSFTLSYLFLGKFIGEIVKSTSIKEHVCPAGSYFLLKWLLLLLLIRNRHRVPGNCQPNKVEKFPHNMTSITSRISSCPPTLLLIGPVSCPIAGRLLRAAGHYAHPYWEHRSGRKLLPTALELDASGARRPTNKRRSQAGQGMTSGTKGTKCGQVWSPRDPASMAHCKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJR7</accession>
    <name>A0A075AJR7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162311.1">
        <property type="nucleotide sequence ID" value="XM_009164047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJR7"/>
    <dbReference type="STRING" id="6198.A0A075AJR7"/>
    <dbReference type="GeneID" id="20314490"/>
    <dbReference type="KEGG" id="ovi:T265_00302"/>
    <dbReference type="CTD" id="20314490"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41257" checksum="1614052EABE2DF8E" modified="2014-10-01" version="1">MTITPHMEEWRSPGTYLKAKALSLIELDNRTAQRRLFTEIQSSKARSALGLSATPTPYIPRVIASGSPDTRREKSLVFRSCTKIPGLRQLRYASSTVKPSLFDELKSSGQNVIVSASRGDGIAILAMNFQAKKNALSKTFVEDFSKAVSELEKDDKSIVAVVCSLVPNVFCAGADLKERAEVPDEKTPALVGGLRSLFQRIYALPFPVVAAVDGSALGGGLELALACDVRFVGNLPRSQIGLIETQWALLPGAGGSQRLPRLIGVSKAKELMFAARRLNPVQAAELGIANAVVNPDEVPDEWKDKPALYRSLEYASELTSKGPIALRQLKRAVNEGLSSGSLERGLEVEGACYRILVPTRDRKEGMKAFAEKRAPIYHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJT4</accession>
    <name>A0A075AJT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_00373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162382.1">
        <property type="nucleotide sequence ID" value="XM_009164118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJT4"/>
    <dbReference type="STRING" id="6198.A0A075AJT4"/>
    <dbReference type="GeneID" id="20314561"/>
    <dbReference type="KEGG" id="ovi:T265_00373"/>
    <dbReference type="CTD" id="20314561"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19684" checksum="0A20C8B2CE67B0C2" modified="2014-10-01" version="1">MKPDPVSNWSIKGRDVAHHATRMGNLMAGFSGTESPHLQDLSVEVEATQNGRCEGKKRELHSLLAPSEFREQGCRMVNYIADYLESTDKLRVFPTVNPGYLARLIPKEAPEEPEPWSKIMEDVNRVIMPGITHWQHPRFHAYFPSGTSCPSMCADILTNGFGCIGFTWRLALVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU04</accession>
    <name>A0A074YU04_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604536">
        <property type="protein sequence ID" value="KER18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177972.1">
        <property type="nucleotide sequence ID" value="XM_009179708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU04"/>
    <dbReference type="STRING" id="6198.A0A074YU04"/>
    <dbReference type="GeneID" id="20330331"/>
    <dbReference type="KEGG" id="ovi:T265_16166"/>
    <dbReference type="CTD" id="20330331"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10057" checksum="1737289087E6C77F" modified="2014-10-01" version="1" fragment="single">MFYQLNVSDPRPSIDYLHNTSPFQSANPARQGVHTVFSESAGIGKKGSVHSPGYPTRYPLSTFKAYTFTGQPYEHVYLKFLMVELGKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUX5</accession>
    <name>A0A074YUX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599539">
        <property type="protein sequence ID" value="KER18581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177672.1">
        <property type="nucleotide sequence ID" value="XM_009179408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUX5"/>
    <dbReference type="GeneID" id="20330128"/>
    <dbReference type="KEGG" id="ovi:T265_15963"/>
    <dbReference type="CTD" id="20330128"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="7834" checksum="4A65A7D52E21AA33" modified="2014-10-01" version="1" fragment="single">MEQDQFSSGVRLINDKDSTRRRSAKLNPKSSSPDSPGFRAFRKLTTNRPTDVWSYKYIYLNTAYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV15</accession>
    <name>A0A074YV15_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Papain family cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_15994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL600051">
        <property type="protein sequence ID" value="KER18538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177715.1">
        <property type="nucleotide sequence ID" value="XM_009179451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV15"/>
    <dbReference type="STRING" id="6198.A0A074YV15"/>
    <dbReference type="GeneID" id="20330159"/>
    <dbReference type="KEGG" id="ovi:T265_15994"/>
    <dbReference type="CTD" id="20330159"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="101"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER18538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26605" checksum="414B623E0D9B47B0" modified="2014-10-01" version="1" fragment="single">MLNMFDEFQEPDDARALYEEFKLKYKKTYSNDDDELRFRIFKDNLERAKRLQAMEQGTAEYGVTQFSDLTSEEFKTRYLRMRFDEPIVNEDPTPQEDVTMDNSNFDWRDHGAVGPVLDQGDCGSCWAFSVIGNVEGQWFRKTGDLLGLSEQQLIDCDHSDQGCDGGYPPQTYSAIEEMGGLELRSDYPYTGKDGICYMDQSKFVAYVNGSTRLPWCEKTQAKSLKEIGPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV44</accession>
    <name>A0A074YV44_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599077">
        <property type="protein sequence ID" value="KER18631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177622.1">
        <property type="nucleotide sequence ID" value="XM_009179358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV44"/>
    <dbReference type="GeneID" id="20326377"/>
    <dbReference type="KEGG" id="ovi:T265_12209"/>
    <dbReference type="CTD" id="20326377"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11625" checksum="6FEB60A8766FC893" modified="2014-10-01" version="1">MTKYLIWTVYGAWFAIDTVEGKQKVCTTAEATVEDLIWFGIRFLLQKKTDHHVVMPGKMTIDFYAYTRQQIIIPVPHIWLSALPGQEVENERIQEHAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVL8</accession>
    <name>A0A074YVL8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597856">
        <property type="protein sequence ID" value="KER18816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177438.1">
        <property type="nucleotide sequence ID" value="XM_009179174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVL8"/>
    <dbReference type="GeneID" id="20329975"/>
    <dbReference type="KEGG" id="ovi:T265_15810"/>
    <dbReference type="CTD" id="20329975"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8393" checksum="9ABB9F7D9EEE96EC" modified="2014-10-01" version="1" fragment="single">MNAAHLLVESSAHSILAVCNAKRNFCVFGCRVTQNDDYGEKKCVEVQQILTLYVEGHIINETFACLVAVSNKMTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWD7</accession>
    <name>A0A074YWD7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597394">
        <property type="protein sequence ID" value="KER18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177256.1">
        <property type="nucleotide sequence ID" value="XM_009178992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWD7"/>
    <dbReference type="STRING" id="6198.A0A074YWD7"/>
    <dbReference type="GeneID" id="20329874"/>
    <dbReference type="KEGG" id="ovi:T265_15709"/>
    <dbReference type="CTD" id="20329874"/>
    <dbReference type="OrthoDB" id="5970915at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="359" mass="39108" checksum="04609B571CD56C16" modified="2014-10-01" version="1" fragment="single">LVAACNTLSVEKVSDGKIETFLEPVKLQGISFTKRYMNTSVPTMVRFNVTTTLASDDLTLSWLFDGAQLNVLRIKGPLPDNPGTAYSTELQGENSVEITLHLRDKSLSVGNYTLVVSATTEAVTQSAQASGFVRAAPILPLFPKDRRVLEGDRLLISCEVIAFPKPDRVIWRFAPIKPDMMKDSDALVEARADLALLGENSSEYQFLTKSVPNDQLLFPQLPSAYNGLYECSVGDPENGDESLILVNVKDRWAALWPFIGIVIEVAVLVTAILLYERHQMRSKPLKVDANATATTAATTTEASSPGMNPRTTQIQQQNNINAVGEPNNETTVDGNKGSNAEAGDNKPDELRLRGGVARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXV2</accession>
    <name>A0A074YXV2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597193">
        <property type="protein sequence ID" value="KER19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176750.1">
        <property type="nucleotide sequence ID" value="XM_009178486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXV2"/>
    <dbReference type="STRING" id="6198.A0A074YXV2"/>
    <dbReference type="GeneID" id="20325911"/>
    <dbReference type="KEGG" id="ovi:T265_11743"/>
    <dbReference type="CTD" id="20325911"/>
    <dbReference type="OrthoDB" id="283553at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="329" mass="36184" checksum="09DB5D307BE1B3B2" modified="2014-10-01" version="1">MQHEKPDLDRLGIFKEMSYVTVGEPYVPPQSHLAMIRTNPRGVPPMYLAGGYSKSKSANADGYFAPFESIHIGDGNVRYADILREARKQSKAKRIGRGEWIPSSGSKLRSGTGSSYGNFQERYEAFDPARKVVSRVPELKNFYTNPGKKGTGYGYVDVCLNPYPSATVGDTPGEIARRTYEAQIKDHIAKLKGRKPFISTCRTLDAFDGNPWAEGDPLAPGGPSTMKFGTAAFPKSMIIGPTFVPSSPAKRDGGKKDGTLNPFPEYSSEPYVGLQGIRKEDKSKFVGPQWIPNPGTALVIPTPSIVAKNTMLHFNSKTRKSRQKVWDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYT2</accession>
    <name>A0A074YYT2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176422.1">
        <property type="nucleotide sequence ID" value="XM_009178158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYT2"/>
    <dbReference type="GeneID" id="20325658"/>
    <dbReference type="KEGG" id="ovi:T265_11490"/>
    <dbReference type="CTD" id="20325658"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="106" mass="11971" checksum="6AA7B19C5A41AD5E" modified="2014-10-01" version="1">MGLRITPKQEVGSDIRRAERTEAWNDDDDEEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDRCIMKSPDSSHTGLNSDMIRSHYGESLSTGSRASSLPELPLVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ04</accession>
    <name>A0A074YZ04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_12275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL601334">
        <property type="protein sequence ID" value="KER18437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177816.1">
        <property type="nucleotide sequence ID" value="XM_009179552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ04"/>
    <dbReference type="STRING" id="6198.A0A074YZ04"/>
    <dbReference type="GeneID" id="20326443"/>
    <dbReference type="KEGG" id="ovi:T265_12275"/>
    <dbReference type="CTD" id="20326443"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER18437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="285" mass="31614" checksum="A953475E538401E5" modified="2014-10-01" version="1">MVVLNQPSMISPTNFLLTMLALSDGALTALYIPFSIYFQIGDRLQSATYGWSVFMIIYVNLQTLLHSASCYIVVTVAFFRVLYVRCLVRCQELCSMQRAHLAVGITFLLSGILTVPCMLSHHIVNVAASNTSASDSYMVTYVDNKALPNIMYWNSALFIKLLPLMCLVVLSLIIIVTIHGKNAQMRKIVSSKRSSTMPKGSSNPPEDGAMHQNKGEGNPLRKHGRSSVTLRQTDTPPTNGTNLLRNSAAQTEREKSGSRMTRMLLTIVFLFVMAHLPQVCDFMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZW9</accession>
    <name>A0A074YZW9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597066">
        <property type="protein sequence ID" value="KER20336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175913.1">
        <property type="nucleotide sequence ID" value="XM_009177649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZW9"/>
    <dbReference type="STRING" id="6198.A0A074YZW9"/>
    <dbReference type="GeneID" id="20325254"/>
    <dbReference type="KEGG" id="ovi:T265_11086"/>
    <dbReference type="CTD" id="20325254"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="155" mass="18000" checksum="1E4594C93D85819A" modified="2014-10-01" version="1">MEVRDHKLQSGTKVQPEHDGRASGVKCHQSCIDAYNELKLRKNHRYILFHIRNNEEIQVLRKADRNATYEDFYQDLITAMDEGEGRYAVYDYEVPGKLPTLIFISWNPSPLSIKTKLIYAASKDAIRLKLIGIKHEVEANDIDEIAEEELRKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z012</accession>
    <name>A0A074Z012_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597062">
        <property type="protein sequence ID" value="KER20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175866.1">
        <property type="nucleotide sequence ID" value="XM_009177602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z012"/>
    <dbReference type="STRING" id="6198.A0A074Z012"/>
    <dbReference type="GeneID" id="20329493"/>
    <dbReference type="KEGG" id="ovi:T265_15328"/>
    <dbReference type="CTD" id="20329493"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="741" mass="81689" checksum="A38E1D2561A62E19" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0J0</accession>
    <name>A0A074Z0J0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175793.1">
        <property type="nucleotide sequence ID" value="XM_009177529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0J0"/>
    <dbReference type="STRING" id="6198.A0A074Z0J0"/>
    <dbReference type="GeneID" id="20325164"/>
    <dbReference type="KEGG" id="ovi:T265_10996"/>
    <dbReference type="CTD" id="20325164"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="963"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1014" mass="112429" checksum="7778A3BB1B323DA7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0K5</accession>
    <name>A0A074Z0K5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597390">
        <property type="protein sequence ID" value="KER19002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177250.1">
        <property type="nucleotide sequence ID" value="XM_009178986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0K5"/>
    <dbReference type="STRING" id="6198.A0A074Z0K5"/>
    <dbReference type="GeneID" id="20326227"/>
    <dbReference type="KEGG" id="ovi:T265_12059"/>
    <dbReference type="CTD" id="20326227"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1056" mass="113472" checksum="4930F2820977098D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0K6</accession>
    <name>A0A074Z0K6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597041">
        <property type="protein sequence ID" value="KER20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175674.1">
        <property type="nucleotide sequence ID" value="XM_009177410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0K6"/>
    <dbReference type="GeneID" id="20329456"/>
    <dbReference type="KEGG" id="ovi:T265_15291"/>
    <dbReference type="CTD" id="20329456"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="396" mass="44150" checksum="A636CBAB3FB338CF" modified="2014-10-01" version="1">MIQDSSTVVELASPSISARFILPTSVDPETAAAGVAHFLMADLTVGSSSSTLADASLDDGGPWLRACTRRRREKSGAKLKPVLRCSTAQRPDGRRPPAGLSDLVEDDDIETLKSKFASTRAYFLNSDNGTHFLDTLLADLREAFCDIPLDERDSIDVLCLGLGNPAVDRASLRQLAVLDLLIERDPRLTRSRTQLYDPVFRSVSRQFIHHLGMKVIQRNEEACYQLDPNRHHLVILPHCAPVLINNLLFTNWTLDVISRLVLFSNGWKQVRCELLASGEPESLIAEELVYIHTLEPLVTVGCCNCPVRAKRRGGSKRTEEFDFEGMRVQWFRRTNLLSLPSGTWTIRSPNKSGHSSNSTEGSDLVHPKTVARNDRFYADLIDQQTVSHFVDTLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z148</accession>
    <name>A0A074Z148_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hemoglobinase</fullName>
            <ecNumber evidence="3">3.4.22.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_10753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">This protease is used by the parasite for degradation of the host globin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.</text>
            <dbReference type="EC" id="3.4.22.34"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.34" evidence="3"/>
    <dbReference type="EMBL" id="KL597023">
        <property type="protein sequence ID" value="KER20766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175482.1">
        <property type="nucleotide sequence ID" value="XM_009177218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z148"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20324921"/>
    <dbReference type="KEGG" id="ovi:T265_10753"/>
    <dbReference type="CTD" id="20324921"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000006">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="514" mass="59454" checksum="56DF211999633C1E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1T2</accession>
    <name>A0A074Z1T2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597204">
        <property type="protein sequence ID" value="KER19452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176798.1">
        <property type="nucleotide sequence ID" value="XM_009178534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1T2"/>
    <dbReference type="GeneID" id="20329702"/>
    <dbReference type="KEGG" id="ovi:T265_15537"/>
    <dbReference type="CTD" id="20329702"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="126" mass="13826" checksum="865EE9712C7EE8E7" modified="2014-10-01" version="1" fragment="single">MEAFGEHSHLNKINTPGTCMKIADIRKYNHNCDKLDPSGEHKPYVPTDGFLRGKCREFANNVRVDASTPCRGISGKSSDSYLSDLVIGCPIHIDVLDGTEGYFVQLASFDVYGASCLLVRFPEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1U0</accession>
    <name>A0A074Z1U0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597202">
        <property type="protein sequence ID" value="KER19462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176790.1">
        <property type="nucleotide sequence ID" value="XM_009178526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1U0"/>
    <dbReference type="GeneID" id="20325940"/>
    <dbReference type="KEGG" id="ovi:T265_11772"/>
    <dbReference type="CTD" id="20325940"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19251" checksum="D40E1167C9DEDDA1" modified="2014-10-01" version="1">MSPLLPQRSLDLSKFSRLNKRTCSRLSDVIIVPDSPNDHPATVLVVAIDLPASQEFSVRQRCTRLKPTGQLFGFSCGALWVWYFCSYSHHSCLNGVIVPIKQIDKASNAEVLRKTNASHTKRSLFCQDYCDEQPALASKNNPSILLHVTRANVVAFWKIPKQKMTVSAVKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1V3</accession>
    <name>A0A074Z1V3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597006">
        <property type="protein sequence ID" value="KER20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175279.1">
        <property type="nucleotide sequence ID" value="XM_009177015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1V3"/>
    <dbReference type="STRING" id="6198.A0A074Z1V3"/>
    <dbReference type="GeneID" id="20324764"/>
    <dbReference type="KEGG" id="ovi:T265_10596"/>
    <dbReference type="CTD" id="20324764"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="290"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="46443" checksum="4F5301568B429CE4" modified="2014-10-01" version="1">MPGIRMETKRTAISLSVERSLAGSGFTEEGLGDLAVSQPSFLLRVAWQLGAKWCYSQTIYFLYSPTDHICHATQRKHEGLDTARLPKPRQGKSRGGGWARTTYLPWPFLLAAVSIQQMTNRLLTGGECPQGVLDVIEGAIGYLALSNGFAAIEYAALRILSNIFLSFVEDVGASALSHAESTGRTTILLSDVILALIDSGFDLKGLEELPRRRQYRGFKEPIAIGSSNGRGVACSAIIGPSGATIIPRPLSLRSDWPPSGRGMGSGNVQHNTTCAVPEQSLPPPAPAHLHLPGLPEPHTFLHTKVKRPPVTSDPISLRRRVAEQRRKVQQSLVQFLSRIQPVQYLFPGDTESFMLLTPKKSSRPYLAALLAESTADASPTDQRDSGQCTTVAKSRAPSSLCLNTMAKSNTSSSSLAGNPYLLKPKFPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1Z1</accession>
    <name>A0A074Z1Z1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597191">
        <property type="protein sequence ID" value="KER19512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176744.1">
        <property type="nucleotide sequence ID" value="XM_009178480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1Z1"/>
    <dbReference type="GeneID" id="20329686"/>
    <dbReference type="KEGG" id="ovi:T265_15521"/>
    <dbReference type="CTD" id="20329686"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="182" mass="20452" checksum="D83A655AA93006F1" modified="2014-10-01" version="1" fragment="single">INITDDVAASDDDDDGGGDDDDDDGDGDDDDDDDDDDDDDDDDDDDDKCRIPPGGINSYAYTQRFENLPHTSSGLGMYNNRKRRRVNCVAERKCAARFLWRVMKGGEKMDNVDSIAMKNLKEWIKCIWWSPQYFGLTTKQTSPSRPHSSMGERYETSASAFAPVIGENLDLAKTPLMSQYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2A2</accession>
    <name>A0A074Z2A2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596992">
        <property type="protein sequence ID" value="KER21123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175129.1">
        <property type="nucleotide sequence ID" value="XM_009176865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2A2"/>
    <dbReference type="GeneID" id="20324651"/>
    <dbReference type="KEGG" id="ovi:T265_10483"/>
    <dbReference type="CTD" id="20324651"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15619" checksum="66D0057203BF9A15" modified="2014-10-01" version="1">MSQQPTTRIRKLRYRAGFCPGRECINHILTLRRVLGEPNSFNHPMVHRIYSSDERNVTRQMMEYFSGHEYRSFAEFQSKLREFQRGTGTCYARRHSLSAAKYEQNVGKVLPPSGGYAFVVYKCVHARSHWKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2G6</accession>
    <name>A0A074Z2G6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596981">
        <property type="protein sequence ID" value="KER21246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174995.1">
        <property type="nucleotide sequence ID" value="XM_009176731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2G6"/>
    <dbReference type="GeneID" id="20324543"/>
    <dbReference type="KEGG" id="ovi:T265_10375"/>
    <dbReference type="CTD" id="20324543"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="14989" checksum="09307ABC88793829" modified="2014-10-01" version="1">MRLERESADQVRGLKPTSASQLTLSRVGQPGMIPALVPPSGGMAARHRKDVTGTTFSSRPGLIQAVEKFSATLCVVHYVYACIMISRISWQLKHEAAWCSTYSFLKSSQTRYSAGFQTSLSQNKNLFANEYISPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3C9</accession>
    <name>A0A074Z3C9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">XRCC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596957">
        <property type="protein sequence ID" value="KER21561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174689.1">
        <property type="nucleotide sequence ID" value="XM_009176425.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20329224"/>
    <dbReference type="KEGG" id="ovi:T265_15058"/>
    <dbReference type="CTD" id="20329224"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010585">
        <property type="entry name" value="DNA_repair_prot_XRCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="3">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="197" mass="22226" checksum="9B8A817860EA216C" modified="2014-10-01" version="1" fragment="single">MTVEQYKYKLLSALKLHPTDPQFTVERLDSSLQILWSKEVKKGIQVNFGTLSLPVSESPMQNIQEVVEALANQVRQLNEQNSRVMEEHEKLRKTADAAVQKYDQLVADTETREVTLLKHFVEVLNEKKRKIAELQGSQTSPTPRGACLTKIPAXLAKSFASEDSLDDGEELLPKIPRTSKSVLSRAFPARRGRKSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6S0</accession>
    <name>A0A074Z6S0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596875">
        <property type="protein sequence ID" value="KER22886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173373.1">
        <property type="nucleotide sequence ID" value="XM_009175109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6S0"/>
    <dbReference type="GeneID" id="20323297"/>
    <dbReference type="KEGG" id="ovi:T265_09118"/>
    <dbReference type="CTD" id="20323297"/>
    <dbReference type="OrthoDB" id="6253480at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1121" mass="128768" checksum="1C8E478EEBBBA03E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6Y7</accession>
    <name>A0A074Z6Y7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173405.1">
        <property type="nucleotide sequence ID" value="XM_009175141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z6Y7"/>
    <dbReference type="GeneID" id="20328932"/>
    <dbReference type="KEGG" id="ovi:T265_14766"/>
    <dbReference type="CTD" id="20328932"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10839" checksum="3F32A4F15FB41A16" modified="2014-10-01" version="1" fragment="single">LSRRKQQDLNTTRLSKPRQEQSGYRGWVRTTNLPVDFSINNTECEKTAVDKHHLSHCVDTHSLPSNIRVRTKCVYTRRFNTTNGCQYVSGRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7X2</accession>
    <name>A0A074Z7X2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_08785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KL596855">
        <property type="protein sequence ID" value="KER23301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172949.1">
        <property type="nucleotide sequence ID" value="XM_009174685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7X2"/>
    <dbReference type="STRING" id="6198.A0A074Z7X2"/>
    <dbReference type="GeneID" id="20322964"/>
    <dbReference type="KEGG" id="ovi:T265_08785"/>
    <dbReference type="CTD" id="20322964"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="344"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER23301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="810" mass="90568" checksum="EA0DD437D0510888" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z842</accession>
    <name>A0A074Z842_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596945">
        <property type="protein sequence ID" value="KER21717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174533.1">
        <property type="nucleotide sequence ID" value="XM_009176269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z842"/>
    <dbReference type="STRING" id="6198.A0A074Z842"/>
    <dbReference type="GeneID" id="20324190"/>
    <dbReference type="KEGG" id="ovi:T265_10022"/>
    <dbReference type="CTD" id="20324190"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19233" checksum="59982876D6AC6D7B" modified="2014-10-01" version="1">MIGLVPYQRLACKRHGDPRWISGSSAKLLTEKSGWFEREVTHRKVRGSNRLLSRLEQPGSIPALVLPSGGTAAKHWKKATAEQFSVTQLILIVRYQAQGFHHHPLNLALTMSPRLAIKRLQSNCQARRTDQQPNSALELPAFHITSFIINIASCKNHVLAVRCSSFYSFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8K3</accession>
    <name>A0A074Z8K3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596849">
        <property type="protein sequence ID" value="KER23463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172816.1">
        <property type="nucleotide sequence ID" value="XM_009174552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8K3"/>
    <dbReference type="GeneID" id="20322860"/>
    <dbReference type="KEGG" id="ovi:T265_08681"/>
    <dbReference type="CTD" id="20322860"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="87" mass="10062" checksum="6DA5C82C955677F1" modified="2014-10-01" version="1">MSIVYRGSRSSFTTFHSELKLSLVLTQDNDYHPPLENEIARRNTLLIRLLKILRQPMTSFALLEVHESGDSQTPNYLQICKTVQRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9A9</accession>
    <name>A0A074Z9A9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trematode PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596833">
        <property type="protein sequence ID" value="KER23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172415.1">
        <property type="nucleotide sequence ID" value="XM_009174151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9A9"/>
    <dbReference type="GeneID" id="20322546"/>
    <dbReference type="KEGG" id="ovi:T265_08367"/>
    <dbReference type="CTD" id="20322546"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="PH_trem"/>
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        <property type="entry name" value="PH_trem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trematode PH-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="322" mass="37124" checksum="3C71B890228D6250" modified="2014-10-01" version="1">MSRQKKHRDSAAPRGSTYIDGQLIHMATQQKLFFQTHVCTINRETLKPGVPFRRADAERFMEKNLKKRQAHGIGNILEDRFTIEKHKSGGKDPFRSWVGYNEIVAIQRSKSKAEFFVLSVDSKSGQNYYEVYKCKTKEDAYKFESYIKQAMEDAEHRVRDGPAIAVVSVVEDPDLRRSMVHIDFQTSQDSLDEDYRTSTVFQNTSPTPPAGYSTPPKARTPSPVPVPQVVYQPTVRAEAPRPPSPRRSPSPRPTKTINGLNDVTYIKYDPRTHYPRASLDGPIYMYLQRHENKYKSDQRRYNSTDLSYGTYQDGYSTAQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA71</accession>
    <name>A0A074ZA71_OPIVI</name>
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        <recommendedName>
            <fullName evidence="11">Fibronectin type III domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_08202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596825">
        <property type="protein sequence ID" value="KER24028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172201.1">
        <property type="nucleotide sequence ID" value="XM_009173937.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A074ZA71"/>
    <dbReference type="STRING" id="6198.A0A074ZA71"/>
    <dbReference type="GeneID" id="20322381"/>
    <dbReference type="KEGG" id="ovi:T265_08202"/>
    <dbReference type="CTD" id="20322381"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
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    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
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    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704001" description="Fibronectin type III domain protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="301"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="403"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="539"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="835"/>
            <end position="933"/>
        </location>
    </feature>
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            <begin position="1281"/>
            <end position="1309"/>
        </location>
    </feature>
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        <location>
            <begin position="1339"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1339"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1409" mass="154415" checksum="164515CA89C9120F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAT4</accession>
    <name>A0A074ZAT4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZAT4"/>
    <dbReference type="GeneID" id="20322238"/>
    <dbReference type="KEGG" id="ovi:T265_08059"/>
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    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="36338" checksum="C29B6200EB370DDA" modified="2014-10-01" version="1">MLSGRRGWSEECVIRHPWNDVMRAVQNKYPNPQNNSVLNMDVIKRSVDLRTGTIHSLKLLNSSFSTFLHLGQLRAVEWSTIDRKEKRMVTVSHNISLRAVMKAVEHLEYSEHPENKDWTLVKHSVTIDAISPIAAAASSTSRMNAQQGREALSWVIRHRLPLLHSFPHWKWNYYPDSSCEEVLPATEPIHTLPAAADSSSMETTGRSSSAPASPSWNWTQGILASPVTTAMAEEPSSALIDIPPSCPAPEPPHSRPTKPRFFSDATLETPSPEPPRSVDSPIHRLGSHFETLTRDVTAMSDALLRRSQRVARLFSKIDEYVVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB86</accession>
    <name>A0A074ZB86_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596805">
        <property type="protein sequence ID" value="KER24561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171681.1">
        <property type="nucleotide sequence ID" value="XM_009173417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB86"/>
    <dbReference type="STRING" id="6198.A0A074ZB86"/>
    <dbReference type="GeneID" id="20321976"/>
    <dbReference type="KEGG" id="ovi:T265_07797"/>
    <dbReference type="CTD" id="20321976"/>
    <dbReference type="OrthoDB" id="10067503at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="195" mass="21062" checksum="090738AC29B5AD6E" modified="2014-10-01" version="1">MTSVGSSIEVLSGTCLPATEYGTSPPGSIPVGVEVTKHMVGTSILDQESVINMQAALYRYASHGRLHKRLGDPHYKSSCRSRSTGVRSNSSPSNKPTSTIRSNDFLTVLKVGLPDQSQSAGLTSPISQTHLSFLQNPLKPTPCHHLRQPDRYPRSTSVGHLGCLIRSWRRLAKKPSPSLPALVVEPTADVLLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB96</accession>
    <name>A0A074ZB96_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sodium bile acid symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171855.1">
        <property type="nucleotide sequence ID" value="XM_009173591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB96"/>
    <dbReference type="GeneID" id="20328595"/>
    <dbReference type="KEGG" id="ovi:T265_14429"/>
    <dbReference type="CTD" id="20328595"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705024" description="Sodium bile acid symporter family protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64610" checksum="0D3648053FC796BE" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBZ5</accession>
    <name>A0A074ZBZ5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_07614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171442.1">
        <property type="nucleotide sequence ID" value="XM_009173178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBZ5"/>
    <dbReference type="STRING" id="6198.A0A074ZBZ5"/>
    <dbReference type="GeneID" id="20321793"/>
    <dbReference type="KEGG" id="ovi:T265_07614"/>
    <dbReference type="CTD" id="20321793"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="435"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="368"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="573" mass="64010" checksum="FDBB4B80E48C66F9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD91</accession>
    <name>A0A074ZD91_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcyphosin-2 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596991">
        <property type="protein sequence ID" value="KER21145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175121.1">
        <property type="nucleotide sequence ID" value="XM_009176857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD91"/>
    <dbReference type="STRING" id="6198.A0A074ZD91"/>
    <dbReference type="GeneID" id="20329325"/>
    <dbReference type="KEGG" id="ovi:T265_15160"/>
    <dbReference type="CTD" id="20329325"/>
    <dbReference type="OrthoDB" id="6265397at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057461">
        <property type="entry name" value="CAYP2_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25348">
        <property type="entry name" value="PH_CAYP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcyphosin-2 PH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="489" mass="56496" checksum="424CAFAA0E6F4C8D" modified="2014-10-01" version="1">MTVHPAQLSPHLTVKQTMPFTARLSVFNPSDVSACTHVNFRPDFPWKNSISSWSLRSYVGLAFLDDSTWMLNEKHPTRSSMRPMPFLPRAVHHCAYGRRKGCPYIPEVDIFPGATLFVRFEEAANAPEQLRHFLNHTKGVLRIRICTVDSEKRQCAIEAEMRRQQIPRDMWIRVIAKLQVAHFPLEPELHLKLAKLQATWRNALRRRTRPVEAYVNLYKHYRLEFNKNLCHPSGFIRGTVATIDTDVASRAVLEQGLHWFQLPQLHPDDLEVVWRAHQATGGYTGPVHFSDYLHLIFGELPEARRQLISEVFLKVDSHQFGYVKLIDLSRFYQEPRWALKEFGDQLESSRNETVGINFTSSPNGTPWNTESRTASGLVVVALIRSSYFVTEQQPTYKQPTFSVFLNFQRLFDPINWSVPLDTLAHQETQWKFVNIVSSLYSQTSGRVRVYGEFPKGFCTQNGCRQNCRPGMSRRHFSRFQRDDGSGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDF5</accession>
    <name>A0A074ZDF5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170947.1">
        <property type="nucleotide sequence ID" value="XM_009172683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDF5"/>
    <dbReference type="STRING" id="6198.A0A074ZDF5"/>
    <dbReference type="GeneID" id="20328396"/>
    <dbReference type="KEGG" id="ovi:T265_14230"/>
    <dbReference type="CTD" id="20328396"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="45"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER25331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="910" mass="101067" checksum="987FBFAAB6AA40E9" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDS4</accession>
    <name>A0A074ZDS4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596974">
        <property type="protein sequence ID" value="KER21345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174916.1">
        <property type="nucleotide sequence ID" value="XM_009176652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDS4"/>
    <dbReference type="STRING" id="6198.A0A074ZDS4"/>
    <dbReference type="GeneID" id="20329280"/>
    <dbReference type="KEGG" id="ovi:T265_15115"/>
    <dbReference type="CTD" id="20329280"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17063" checksum="1BBBAD93C811A8CA" modified="2014-10-01" version="1">MYRLNANPSTPEGNSSAETPVYRTPRSTFDLLKPPKEEVVSSNQKMMQSGDILTSDRAGKNYRGITHLGVKEKSLGESKISSMMFAWVPKLRRANQFKEAYSQPTRRLNSLPLNILTEHLGTKKRSTTDTQSSCVPIITKDGIQENASDKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFE1</accession>
    <name>A0A074ZFE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_06716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170317.1">
        <property type="nucleotide sequence ID" value="XM_009172053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFE1"/>
    <dbReference type="STRING" id="6198.A0A074ZFE1"/>
    <dbReference type="GeneID" id="20320895"/>
    <dbReference type="KEGG" id="ovi:T265_06716"/>
    <dbReference type="CTD" id="20320895"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="961" mass="106693" checksum="AC1CD9913B8E5809" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFL8</accession>
    <name>A0A074ZFL8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596924">
        <property type="protein sequence ID" value="KER22030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174220.1">
        <property type="nucleotide sequence ID" value="XM_009175956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFL8"/>
    <dbReference type="STRING" id="6198.A0A074ZFL8"/>
    <dbReference type="GeneID" id="20323950"/>
    <dbReference type="KEGG" id="ovi:T265_09782"/>
    <dbReference type="CTD" id="20323950"/>
    <dbReference type="OrthoDB" id="419198at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705174" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="40394" checksum="5164AB20B4FCEDD0" modified="2014-10-01" version="1">MFKAIVGILAVVCFLLLTRWYASQAPQIIVTAPDISLAPFLVLPHLDEKQVRMLPDLSKLQWPPDPIASVPAGRRNAMGKVEPLPDAFMPVMSAGQRALCKHLLQMFADIMFAYGFGDRFMLYGGTLLGSYRHHDFIPWDDDLDVLVDETVRPKMIELLRLLEPEYLFVDQSVRGKLHTRLIKAVNNSEDLPLSRQSSEYPWGWPYLDIGYYTNNGSHVCEIAGSYGRYYCWPLSVLFPLRFRPLGTRWYPVPFDVVQFLNLTYSDLSNCVIFGYSHVLEGAGKRGNLPCSDLTDHYAFVRRERSPWQLNSANNAENRFVLAAEYLFTGSQQIIHTLHIPALKNEITSDLFRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG05</accession>
    <name>A0A074ZG05_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_06479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170017.1">
        <property type="nucleotide sequence ID" value="XM_009171753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG05"/>
    <dbReference type="STRING" id="6198.A0A074ZG05"/>
    <dbReference type="GeneID" id="20320658"/>
    <dbReference type="KEGG" id="ovi:T265_06479"/>
    <dbReference type="CTD" id="20320658"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER26196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="518" mass="59280" checksum="A885EC10B9BE12DB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG39</accession>
    <name>A0A074ZG39_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596912">
        <property type="protein sequence ID" value="KER22200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174057.1">
        <property type="nucleotide sequence ID" value="XM_009175793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG39"/>
    <dbReference type="GeneID" id="20323821"/>
    <dbReference type="KEGG" id="ovi:T265_09653"/>
    <dbReference type="CTD" id="20323821"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="20274" checksum="1B0887A7F4DACD0E" modified="2014-10-01" version="1">MLQLARYSRRDTFCGHNALLISYTKREISRHQTSGGQRMNTTSEGKKGFAVMLIRETPTEPLQTIGKGSKSLLCILFTKVNIHLLLESVFLNFLGYSLTAAQMQANTTNTLLGSVVVRSSWLVCVKLLSSANEPIIICESIWFKRGTQLNDDILQLNVLHTGRLMFQLVRYLRYRGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG81</accession>
    <name>A0A074ZG81_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_14028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169962.1">
        <property type="nucleotide sequence ID" value="XM_009171698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG81"/>
    <dbReference type="STRING" id="6198.A0A074ZG81"/>
    <dbReference type="GeneID" id="20328194"/>
    <dbReference type="KEGG" id="ovi:T265_14028"/>
    <dbReference type="CTD" id="20328194"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF349">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE BRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER26291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="414" mass="48202" checksum="981EF2B388646F98" modified="2014-10-01" version="1" fragment="single">MKLIFTAVTLQLATTLFIILWLSMMSQQNKSRLSKSADLDSKSQQKITDVLKLKPDEVTRWEALTELDGAKYYGPEAFNVKNCSNDAFVSFETQVSTIRKYTFIGTELFNYMQNKDVVEKICQFKQRRSILNDASEWQDYELLINQPKVCSNREAALVDLLMLIKSAHNHEAERNTIRSLWANNSCWDGRTVRHVFLLGSTDNVTWTKRIAREARRFADVIQQDFHDDYYNNTLKVLFGLQWALSFCPEAQWILFVDDDVFVNPRNVLALLKSLDFRFYRSLLFGNQRTFPPVTREKSKWAIDEDIYPHDYYPSYVSGATILVGSKLAIDLYIGSRFTRMIPFDDAFFGLVLNALLLIPVHLRGIYVDDYSELSKLSRSRQFTVHGVSSPLRQRRLWIQMRASEMCYPPENQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI83</accession>
    <name>A0A074ZI83_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596774">
        <property type="protein sequence ID" value="KER25512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170739.1">
        <property type="nucleotide sequence ID" value="XM_009172475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI83"/>
    <dbReference type="STRING" id="6198.A0A074ZI83"/>
    <dbReference type="GeneID" id="20328358"/>
    <dbReference type="KEGG" id="ovi:T265_14192"/>
    <dbReference type="CTD" id="20328358"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23731" checksum="F6841F3E4424871B" modified="2014-10-01" version="1" fragment="single">MSSVNQIAVDLHGNDVIYSFLKRCLECDDLPGKLRDLVQPIVDSKSTIPFVTLYECHSWLKCRQENPGPLWKLFASTTVVLPAPKEPVRNADLDKRVKALREKFSNQAYDKMVEGIEPKLTLFDSMKVSGTNSSLCSELKCLNKQMVMVLNFIIVVSAGFVFGYFIPDMLSSNPDISLATRLMCGLSVSLVIFFADLYFLIKNVSEAEKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ31</accession>
    <name>A0A074ZJ31_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172881.1">
        <property type="nucleotide sequence ID" value="XM_009174617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ31"/>
    <dbReference type="GeneID" id="20322911"/>
    <dbReference type="KEGG" id="ovi:T265_08732"/>
    <dbReference type="CTD" id="20322911"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="26585" checksum="B9A6201B75F6D16A" modified="2014-10-01" version="1">MLHPCLFTIISETTHDFRKRRHIAGSTQLCDICGPTSFNTSANVCLPTSVPPSITPPAGYLAALILLTRMRILQEGSTPSSTDSPTIDKYTDIIGYVVTEAELTDNERQQSGGVFVERPASHHTSKTLAVAIIQFYLLVQSYSVESENKEDVFKITLMCIQVQLGAFHSKLEQVRGQVHKDETKEIEVPYQKREYPVAVLGIELSTSDMRRERVTATPPVDVGLIPTFAFEKVNLFALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ76</accession>
    <name>A0A074ZJ76_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596851">
        <property type="protein sequence ID" value="KER23405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172873.1">
        <property type="nucleotide sequence ID" value="XM_009174609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ76"/>
    <dbReference type="STRING" id="6198.A0A074ZJ76"/>
    <dbReference type="GeneID" id="20322908"/>
    <dbReference type="KEGG" id="ovi:T265_08729"/>
    <dbReference type="CTD" id="20322908"/>
    <dbReference type="OrthoDB" id="6279146at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="504" mass="57755" checksum="573A2D1C8B758F22" modified="2014-10-01" version="1">MPAHIDREQKGEQQFVLFKQRATYIAVQGISQVRSQICQALIQVLRFLGIIDTHNEKVDEPETKLIRVFNHRITQFDAQRTTLFERLFQEQRFQDWIQLLANALQQNWSAKLYTVLQSSYKITVREFDHLQIVLLLHILHPSVRLTRRINHQRPSACITNQNVKRPLQYPYDGPFKVISRKDKYFVIERNGKPDSVSIDRLKVAFIDDESHSDPPTVVTPPTSSQTSSTAIPGNPEHIARRIDDHPLPILKQTRNRSQAVTTKRGVRCDGVCRVGAMVVGSDERYPWLASMLLVHKPKYETLEFVNLSSVRLQLFQEAFSSVSQPNFKLFAFDLSGSAILFKYIFHSHVPLKDLTVDAHIGWVQLGVIHQEQQTVSGLVQFTLQIMHCHLLSMIDEFGELHHMCNIGWYTIGPKALRTHSPVSHRKQPLAATTWRTLPDNGVLEEPLGATRTNFGLMDDYLEREHFRNKAYQSATKITLSAAHEDKQNEKPPGNNGAARQKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKJ4</accession>
    <name>A0A074ZKJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168719.1">
        <property type="nucleotide sequence ID" value="XM_009170455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKJ4"/>
    <dbReference type="STRING" id="6198.A0A074ZKJ4"/>
    <dbReference type="GeneID" id="20319630"/>
    <dbReference type="KEGG" id="ovi:T265_05448"/>
    <dbReference type="CTD" id="20319630"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="459" mass="53211" checksum="2D04861C6DD13755" modified="2014-10-01" version="1">MSFLWDSFILLFSQLCFFLVGWLFFLRQLFRDYEVDSKIVVIIFSLTFALSCTLFELVIFEILDIFAASSRRIHWQLVLFATLLDVIFVIPFYISFYSSKNLRFFPQTRSFRLAFTMTAMVAYLYLFWKVGSSFPIISPKHGLISFEQCTGRIGVIGVTIMALLSGFGAVNYPYTCMTYFAQSVSNAEIKTAERRLMQTMDMILVKRRRLALAQFEASVRTQASEKSRLWNVLRSVGNSISTSRLNERALLAEVSTLEDLSRQLFLELHYLRTAQERIEFSRTLKGRYFNLLGYFFCGYCFWKIFISTINILFNRIGRQDPITQGITIAVHYLGFEFNVKFWSQQLSFWLVGIIVVTSIRGLLITLTRFFHAIASSNSSGVIVLILAQIMGTYFVSSVLLLRMNMTAEYRSILTQVLGDLQFHFYQRWFEVIFLVSAVCSIGFLHMAHKRVAELKSDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKQ9</accession>
    <name>A0A074ZKQ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168316.1">
        <property type="nucleotide sequence ID" value="XM_009170052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKQ9"/>
    <dbReference type="GeneID" id="20319310"/>
    <dbReference type="KEGG" id="ovi:T265_05128"/>
    <dbReference type="CTD" id="20319310"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21171" checksum="F3366AE05C40856A" modified="2014-10-01" version="1">MPPRRKVRKLIATLFEKTSGQLIRLRTHKLQDRPLSGRAQTKRNVHVQRVTHPQDHHRYDTSRKQLISSAYPMAMAEPELRASDMRRERVVITPPAHGWTSEQLFFPLELRFYVTRLWLEKARQFGVEGQKLNSEILVPSAPRMDSGAATADKPGPLEVGPEFGTLSDPASRRDLIGQQSGPKCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKR5</accession>
    <name>A0A074ZKR5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169861.1">
        <property type="nucleotide sequence ID" value="XM_009171597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKR5"/>
    <dbReference type="GeneID" id="20320538"/>
    <dbReference type="KEGG" id="ovi:T265_06356"/>
    <dbReference type="CTD" id="20320538"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="233" mass="26871" checksum="A22CB4E329FF54A6" modified="2014-10-01" version="1">MRFGKRHFLLTNENMTQSRRVETEEDKLRIYSQSLAFRGRVQTLLESRRNIPASPEHKPMRRTIRRQVKKAKEMEEAQKAGNARRLFQLIRATGPRKPPVSESIKHQNGTTISNKEERLDRWAEYSEQQMSWPPAGTHLQPTGEVEPWTVNVEPPTASEVRLDERSRNRFFQLLDDGASQATKFRESRCNSTMTSTSRILSAPAGLQHMRRTLWLATVSTTQDRLVTDQAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL45</accession>
    <name>A0A074ZL45_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596714">
        <property type="protein sequence ID" value="KER27786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168457.1">
        <property type="nucleotide sequence ID" value="XM_009170193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL45"/>
    <dbReference type="STRING" id="6198.A0A074ZL45"/>
    <dbReference type="GeneID" id="20327887"/>
    <dbReference type="KEGG" id="ovi:T265_13720"/>
    <dbReference type="CTD" id="20327887"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER27786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="652" mass="69283" checksum="83564DA0F446C67D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLV8</accession>
    <name>A0A074ZLV8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">T265_04810</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167912.1">
        <property type="nucleotide sequence ID" value="XM_009169648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLV8"/>
    <dbReference type="STRING" id="6198.A0A074ZLV8"/>
    <dbReference type="GeneID" id="20318992"/>
    <dbReference type="KEGG" id="ovi:T265_04810"/>
    <dbReference type="CTD" id="20318992"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
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    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="705"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="810"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="866"/>
            <end position="886"/>
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    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="59"/>
            <end position="202"/>
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    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
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            <begin position="211"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01003"/>
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        <source>
            <dbReference type="EMBL" id="KER28353.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1109" mass="115138" checksum="06645A5EE5239A30" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM24</accession>
    <name>A0A074ZM24_OPIVI</name>
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        <recommendedName>
            <fullName evidence="6 13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_05015</name>
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    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="Histone_H2A"/>
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        <property type="entry name" value="Histone_H2A_CS"/>
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        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONEH2A"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER28106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="14304" checksum="03E1346EF69D9F6C" modified="2014-10-01" version="1">MSGRGKGGKTHSKGGKKTRSARAGLQFPVGRVHRLLRAGNYGERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNSLLGKVTIVQGGVLPNIQAVLLPKKAAIVGKKSQSQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMI0</accession>
    <name>A0A074ZMI0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167963.1">
        <property type="nucleotide sequence ID" value="XM_009169699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMI0"/>
    <dbReference type="GeneID" id="20327779"/>
    <dbReference type="KEGG" id="ovi:T265_13612"/>
    <dbReference type="CTD" id="20327779"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13670" checksum="EF269062BF677C44" modified="2014-10-01" version="1" fragment="single">MSDLDDGSASATDGDSDGWTELIDADSPDTNPPMKCLVCPHLSSGSEQFFTHLLSHPNWENLFVPGTCLIMDQYDWIRFVNYVRLKPDAVLECASHHVSNDHVDTDYLWAENAALRQQLAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMR9</accession>
    <name>A0A074ZMR9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169192.1">
        <property type="nucleotide sequence ID" value="XM_009170928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMR9"/>
    <dbReference type="GeneID" id="20320003"/>
    <dbReference type="KEGG" id="ovi:T265_05821"/>
    <dbReference type="CTD" id="20320003"/>
    <dbReference type="OrthoDB" id="6273711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="16679" checksum="3F16C291300022E1" modified="2014-10-01" version="1">MSVTEPTKELINSTEVWDPSKHLPSPRRISQNEQIAAILIAVTLLAILTICIVILIIRTMRNRPTPHYTAHPKNRHPSLSDADRMKDEVKPSYTSAAYANPRASTPGLVVVGLRETPTRKVNKKWYDSTAIPFMDDLDNVNESVYGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNB6</accession>
    <name>A0A074ZNB6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169034.1">
        <property type="nucleotide sequence ID" value="XM_009170770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNB6"/>
    <dbReference type="STRING" id="6198.A0A074ZNB6"/>
    <dbReference type="GeneID" id="20319883"/>
    <dbReference type="KEGG" id="ovi:T265_05701"/>
    <dbReference type="CTD" id="20319883"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000389">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="682" mass="77332" checksum="F6969994B9AB587D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPR2</accession>
    <name>A0A074ZPR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_07191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596780">
        <property type="protein sequence ID" value="KER25310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170911.1">
        <property type="nucleotide sequence ID" value="XM_009172647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPR2"/>
    <dbReference type="STRING" id="6198.A0A074ZPR2"/>
    <dbReference type="GeneID" id="20321370"/>
    <dbReference type="KEGG" id="ovi:T265_07191"/>
    <dbReference type="CTD" id="20321370"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704203" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER25310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="477" mass="55407" checksum="9CCBB30B590A6BDC" modified="2014-10-01" version="1">MSKIDELITVCCLVLFGIVTLKTNHVTALIPEQCAHNVSQPFSTCCPTDPFNHLVCGGPERGSCQHLTIHREYVPRVFLMDDRMFWPTRFFDHLCHCKDNFYGVACEQCWFGWTGPHCDQREIRIRRNIRSLSEDELELFKDVMYRSQTWPSGFWVLDEATNNRSDPLFKPRFKSASVQYWAAFIHRYGARPTLYETEEECSRFGILNFSHDGVTFPTWHRYFQLIWERMLSKIALEVHGIHNFAVPYWDVIGLEKCDICNDEYVGGPGHTDRYGVHLSANSAFTGFKEYCLEPEGDEVCFGCQGTKPTTTITRQFLTNAFPNQEDLYFTLNLKDYFIPGERDSEECRSFHMALEGYCGRPDTDPTYRWMHNRLHRMINGSMCCTSTATNDPIFIVFHNFVDKIFNAWLRLHHPPVEAYPKDNVRPGHSRDSFMVALLPLLRNADMFVDSLQLGYDYDNMMFGQFAQNGVPPIIVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRP3</accession>
    <name>A0A074ZRP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_16372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL622317">
        <property type="protein sequence ID" value="KER17989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178264.1">
        <property type="nucleotide sequence ID" value="XM_009180000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRP3"/>
    <dbReference type="STRING" id="6198.A0A074ZRP3"/>
    <dbReference type="GeneID" id="20330537"/>
    <dbReference type="KEGG" id="ovi:T265_16372"/>
    <dbReference type="CTD" id="20330537"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER17989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="52" mass="5955" checksum="FCBD98B10DD5C958" modified="2014-10-01" version="1" fragment="single">MGTEKRSFDGHTVRVTNLQPDTTAEDLKQIFSPFGMVTRIYPAKDKVTQQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRX2</accession>
    <name>A0A074ZRX2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170142.1">
        <property type="nucleotide sequence ID" value="XM_009171878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRX2"/>
    <dbReference type="GeneID" id="20320754"/>
    <dbReference type="KEGG" id="ovi:T265_06575"/>
    <dbReference type="CTD" id="20320754"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704297" description="UPAR/Ly6 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21753" checksum="A16BAD33AA028576" modified="2014-10-01" version="1">MILQITPTLWLVCYIILEAKGLRCFRCIDCPEKIHQGADGVITEECDKQCMMIVYYTSNGTTALTSRLCAICPENAENKGESLTSITTCCSTDLCPEGETGTSDQPTSQRHSPSVTRSSDQSTLRIRSPEGSTRTSGQATLETHAPETSATSTETKMVQVTSEGAAVQTSGLPTGTAECVSEHNAAAAALFVHMFTTWFALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTU8</accession>
    <name>A0A074ZTU8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">guanylate cyclase</fullName>
            <ecNumber evidence="1">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="4.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165298.1">
        <property type="nucleotide sequence ID" value="XM_009167034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTU8"/>
    <dbReference type="GeneID" id="20316907"/>
    <dbReference type="KEGG" id="ovi:T265_02719"/>
    <dbReference type="CTD" id="20316907"/>
    <dbReference type="OrthoDB" id="6259959at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="301"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER30903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="959" mass="109619" checksum="9B253FEEEBED35C9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUF9</accession>
    <name>A0A074ZUF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_03947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596678">
        <property type="protein sequence ID" value="KER29482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166811.1">
        <property type="nucleotide sequence ID" value="XM_009168547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUF9"/>
    <dbReference type="STRING" id="6198.A0A074ZUF9"/>
    <dbReference type="GeneID" id="20318133"/>
    <dbReference type="KEGG" id="ovi:T265_03947"/>
    <dbReference type="CTD" id="20318133"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055320">
        <property type="entry name" value="CEP72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311">
        <property type="entry name" value="HEAT SHOCK REGULATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57217" checksum="13E84410A43C75CB" modified="2014-10-01" version="1">MANKTDDVKTLILQGNCEEKITHLGTALAHFTQLKILDLSRNLLQNIEGIEHIKSLEVLNLYYNSIEDLFEIKRLQCNPNLRDLDLRLNPISRLTADYRRYLSYLLPQLKTLDCRPLRRTESALEDSLPISSEEHNNHPKNERNCTQESTGNTGERFHFGCWKQELLRESSEQIETPLRSRSYADIQKSAKWSHHNNTKIFPSEESPKITSFTGVSPYWLDDHVEKQRSALVEYYSSRDTFPNELELPSANETRVHTEDSYTNHKERAEKASKDAKSNDSIPNDRKTGDSGTYSGSSVTAFIRESAPKPLELPIGKRDSQEKLLKENDISPSGYAKIDQPFLIALKSLIRDAVSESFAQYANRCSVLAPDRRALEQTYHLETCVTSSRSEKAALKLVEQSSVLPEKPSAWTKAITSAAEFVVNGFPTPLTSHCLNFFSSFPPCVWLSGNCCPKIPPLQDWVGSNPHLMLAGEPINVVDKFVYLGSCISSGVFTAIVRSILLYESENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUV9</accession>
    <name>A0A074ZUV9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597396">
        <property type="protein sequence ID" value="KER18994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177259.1">
        <property type="nucleotide sequence ID" value="XM_009178995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUV9"/>
    <dbReference type="GeneID" id="20329876"/>
    <dbReference type="KEGG" id="ovi:T265_15711"/>
    <dbReference type="CTD" id="20329876"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36623" checksum="D7CFCD2A23B917D1" modified="2014-10-01" version="1" fragment="single">PPSSSSFVERHKTDPVYLHVTTEVKLNALELNDTIAYMHSKKCSTKWCYTWIITPSSIKGSTSLVAHSSGDSSRAHENFSSCLATAKCFGVERYHRLHAFQKMFNKMVLYVDSCSSGSMFRDVLPSNMEIYLTTSSNEDEPSYSLFCSDKEIDVCLADEYSYVWVIDSEFNDLKTHTLEEQYTMVKKNTALSHVMKYGEMAMGSLPVGKFQGHYDLLMDRKDGAIASNAVGRKPSCQAHLFSKFRRLVEAATEDEHDSAWRKLHRELPLGLIVKEMSSDIVMDVTTQHKPTQKLLSKRDELVCFKAVFDQFRAHCFTIRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVI9</accession>
    <name>A0A074ZVI9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168888.1">
        <property type="nucleotide sequence ID" value="XM_009170624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVI9"/>
    <dbReference type="GeneID" id="20327979"/>
    <dbReference type="KEGG" id="ovi:T265_13812"/>
    <dbReference type="CTD" id="20327979"/>
    <dbReference type="OrthoDB" id="6236680at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER27395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="488" mass="57166" checksum="487D56BA3C2F14D5" modified="2014-10-01" version="1" fragment="single">MPIDNATNFFWLPTVLKGSRRFTSRPNGSAKGSRDRAIRESDEEESRSSKEVNDGSQNSSAASKYIETDQWYRHRRYRNLILRDHVVKFHVRTNQSLSAWLHEQLALMGQEVDTAIFDLRMLNTGADEFFKPYLATTYTSLVELMRMLMDQYGTHGLQIYLVGWTIRHWLNVCRLHLLRSWLFRAPRRRLLFGVPDELPSLHQMLQEYVQTHTLCCINRDSSLHPGLCTLRQLVSLPHDFYCQPCFARELYRALLRSLCLRYQSSIRNKRKWIHYKRFGLPHQIVLLEAQSRSTERLIGNIKLLMDQILGRNSLNGSPLLPYPVSDSKIAWSPIYDGRFEECSALAGFISLLFVLLFLLLASIVETFAPASKSIIHFEVGIHEPLDISIRDTMMTYFILAPFCVYLNFELRLRLMHMLLPWLPSLTWSYFPCFPSDEVYIAFPQRLFKLGFEINLTWRCFEHYEQRLLHTYQQLLSGLAAWGILVRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW46</accession>
    <name>A0A074ZW46_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597215">
        <property type="protein sequence ID" value="KER19419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176832.1">
        <property type="nucleotide sequence ID" value="XM_009178568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW46"/>
    <dbReference type="STRING" id="6198.A0A074ZW46"/>
    <dbReference type="GeneID" id="20325971"/>
    <dbReference type="KEGG" id="ovi:T265_11803"/>
    <dbReference type="CTD" id="20325971"/>
    <dbReference type="OrthoDB" id="10051210at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="304" mass="34474" checksum="8417B841AB8C891F" modified="2014-10-01" version="1">MLVPTTTGHRARAEHLSRSDPTTTGVAKLRPASAKRDPTTAAGRRGTRSDPFRVHQLSPEFRPRWNLPHHSVVNPKKPGRLRAVFDCAAQSNKESVNDYLYQGPYWTANLTAMVLLFRKERVALSANIEETLMQVRVPENDRGALRFLWWPGSDISLEPVEFQMNSHVFGANYSPFCANFALHQIVELFENDYALIVSEAIRNNFCVHECLLSDPSIDAAKMISTQLTEMFLKPGFHLRKWVTNAPEAIENLFSAKRAESPVTLSGCIPVMLPTPGIRWDTLRDNFCFQYDIPTGHETRRKLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX28</accession>
    <name>A0A074ZX28_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168304.1">
        <property type="nucleotide sequence ID" value="XM_009170040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX28"/>
    <dbReference type="GeneID" id="20319298"/>
    <dbReference type="KEGG" id="ovi:T265_05116"/>
    <dbReference type="CTD" id="20319298"/>
    <dbReference type="OrthoDB" id="6262698at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="256" mass="28796" checksum="CEBCA3A1C7BC1955" modified="2014-10-01" version="1">MVSTAPEGPKRRRNRPSRRALDILRRARETAAAAAQAAAEAAELIARSRGRRRRPPFYARHDAPQSSAMHQPPRSAPADSGHTSVGPNFREMEEGANDGSNADGVKRRRPPGYWARRRKYRRERRAAEAAAAAAESDEFYYGPHGMHMDPFAYPAEFYPDDYPPPECEGYIWPETRGGYPPPLGPSFEVYPGDRMQSHVGRRAGRARNSEYLAQARALIRAQNAGLRTHQDTRRYSAPLVPPEAWGPPTHPYDARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX84</accession>
    <name>A0A074ZX84_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164220.1">
        <property type="nucleotide sequence ID" value="XM_009165956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX84"/>
    <dbReference type="STRING" id="6198.A0A074ZX84"/>
    <dbReference type="GeneID" id="20316034"/>
    <dbReference type="KEGG" id="ovi:T265_01846"/>
    <dbReference type="CTD" id="20316034"/>
    <dbReference type="OrthoDB" id="6589456at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000001">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF21">
        <property type="entry name" value="PROTEIN 4.1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="277"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="783" mass="89559" checksum="EC3FDCC24ABC6BF3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY69</accession>
    <name>A0A074ZY69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168041.1">
        <property type="nucleotide sequence ID" value="XM_009169777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY69"/>
    <dbReference type="GeneID" id="20319099"/>
    <dbReference type="KEGG" id="ovi:T265_04917"/>
    <dbReference type="CTD" id="20319099"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16907" checksum="3F0E837BCC7998C8" modified="2014-10-01" version="1">MVQPDLLPLDFPCPGLGNLVIYEPSCFLRVAWQLGTGGVLQLNDLSVFAFRSDRLTRIQTVYQTKIRWGRPVVDSYVVDSLRERSLSVFTVGISVHDDRNGNQSTVCRQPEEFSSVASIKRRYDQVFSKVDEAFEELDEQISAYTVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYD0</accession>
    <name>A0A074ZYD0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167888.1">
        <property type="nucleotide sequence ID" value="XM_009169624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYD0"/>
    <dbReference type="GeneID" id="20318968"/>
    <dbReference type="KEGG" id="ovi:T265_04786"/>
    <dbReference type="CTD" id="20318968"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="111" mass="12629" checksum="CB9A260343093744" modified="2014-10-01" version="1">MKICVPPSATGSLFELSRKLQGSRESVYDSEASLFNTDVMLSMMMMRESVQRTGGEMAQWSKRKFTDRKVRASNTTSASRPWDPLRAISCGVFNRLPEAHNERVNTKLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYI6</accession>
    <name>A0A074ZYI6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167862.1">
        <property type="nucleotide sequence ID" value="XM_009169598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYI6"/>
    <dbReference type="GeneID" id="20318955"/>
    <dbReference type="KEGG" id="ovi:T265_04773"/>
    <dbReference type="CTD" id="20318955"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7757" checksum="9A6CB3E0FE60B170" modified="2014-10-01" version="1" fragment="single">CFPQSKPWVTPNTLKLWNVFWSSGRRPPMLTTLLAKFWPPFPIHHRPKHQFQRRIRSAYSNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYI7</accession>
    <name>A0A074ZYI7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597078">
        <property type="protein sequence ID" value="KER20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176041.1">
        <property type="nucleotide sequence ID" value="XM_009177777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYI7"/>
    <dbReference type="STRING" id="6198.A0A074ZYI7"/>
    <dbReference type="GeneID" id="20329537"/>
    <dbReference type="KEGG" id="ovi:T265_15372"/>
    <dbReference type="CTD" id="20329537"/>
    <dbReference type="OrthoDB" id="14167at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="205" mass="23958" checksum="4A6FC68C31A6C8D8" modified="2014-10-01" version="1" fragment="single">LPSIPFEYFLLSVNQVENVVSSHREYRLKVPTKLPSEALGDIFFSVSADVGRKPIYGQALRICGEYQRRLGYHEVQRNEAMENHVLLVLFNFLQHEWADLQKELKKLTEARLDYDKARNKIKRLENPDREAIEKMEKLRLTYEQQLEFLRFKLSELKGVQQTHLAALKAFVNIQTKYFTKCKIHSEETASLLEQLGTNEPKSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYQ1</accession>
    <name>A0A074ZYQ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167758.1">
        <property type="nucleotide sequence ID" value="XM_009169494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYQ1"/>
    <dbReference type="GeneID" id="20318872"/>
    <dbReference type="KEGG" id="ovi:T265_04690"/>
    <dbReference type="CTD" id="20318872"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7242" checksum="1D367B4A2401B3F1" modified="2014-10-01" version="1">MATDRRNRHEQAWHHTLEEILLVQNENAYSGLYHNEEPVFNIDDTGGDDWCVPGNLVVPRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ10</accession>
    <name>A0A074ZZ10_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163868.1">
        <property type="nucleotide sequence ID" value="XM_009165604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ10"/>
    <dbReference type="GeneID" id="20315733"/>
    <dbReference type="KEGG" id="ovi:T265_01545"/>
    <dbReference type="CTD" id="20315733"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15161" checksum="C4378893DAB472AC" modified="2014-10-01" version="1">MVARQRSIGVEHAVDDDDDDDDDDDDDDDDDDDDDDDDDHWDDDDEKMLWTDAPKPAKMYISRNAICTSKKREQFTRSPILHLALSLFTDARLYAPEFGVRIAARGVIVVTPFRVAQLSQAIEEAQCVCQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ99</accession>
    <name>A0A074ZZ99_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DnaK family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163500.1">
        <property type="nucleotide sequence ID" value="XM_009165236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ99"/>
    <dbReference type="STRING" id="6198.A0A074ZZ99"/>
    <dbReference type="GeneID" id="20315439"/>
    <dbReference type="KEGG" id="ovi:T265_01251"/>
    <dbReference type="CTD" id="20315439"/>
    <dbReference type="OrthoDB" id="6233374at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000030">
        <property type="entry name" value="Heat shock protein HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59219" checksum="13395ECC35C990B5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZN7</accession>
    <name>A0A074ZZN7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163231.1">
        <property type="nucleotide sequence ID" value="XM_009164967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZN7"/>
    <dbReference type="GeneID" id="20315212"/>
    <dbReference type="KEGG" id="ovi:T265_01024"/>
    <dbReference type="CTD" id="20315212"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="14445" checksum="86009F70E17F27C4" modified="2014-10-01" version="1">MRRPGAANSVAWKHQNREIQLGSSNLMSSALRLNMYRDFSNIVAIKTRGGLVQNIQLPGNITNERLSWVPVTDYRENKLLCSKMFLTRKFLLSLPQNFHQSVTHQEYKDEICLVTYHTLSQWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZV2</accession>
    <name>A0A074ZZV2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164701.1">
        <property type="nucleotide sequence ID" value="XM_009166437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZV2"/>
    <dbReference type="STRING" id="6198.A0A074ZZV2"/>
    <dbReference type="GeneID" id="20327116"/>
    <dbReference type="KEGG" id="ovi:T265_12948"/>
    <dbReference type="CTD" id="20327116"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29272" checksum="12EB25553DB06984" modified="2014-10-01" version="1" fragment="single">CATHPGDKLDIYIGAVSSSNRWRSLCGTNLPVNLRTMNMRVPVLTIQFKSDNQTTAMENGFYLNYRIVSSHDASSESSSKYEPLSDEWKQKEYTLPAEKEANQSLNTKNSGALKKTGEIKRLPKEHKALDTSKTCRCNSPYHLEIITFQNLSTSLPQFTERGHGSREWKLKDYEDDSATSLAFKDFNWIAGDRIKLCFQRDSNEELKNKAFMSSQLPRVDVVLKASFDEWLNDRHSSLQLPEQGEFYSVDYNFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZW0</accession>
    <name>A0A074ZZW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163326.1">
        <property type="nucleotide sequence ID" value="XM_009165062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZW0"/>
    <dbReference type="GeneID" id="20326880"/>
    <dbReference type="KEGG" id="ovi:T265_12712"/>
    <dbReference type="CTD" id="20326880"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="105" mass="11922" checksum="B69B7C6FA2D877A0" modified="2014-10-01" version="1" fragment="single">MSRARHTNRSGVNTFARSDVKIESIAYTLVTQGRSDGFKSRHGYWIRSSQPGQLLGRRSMSRAHQSHRSSVNTFARSDVKIESSAYTLVTQGRCPGFKSRHGYWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0C3</accession>
    <name>A0A075A0C3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164618.1">
        <property type="nucleotide sequence ID" value="XM_009166354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0C3"/>
    <dbReference type="STRING" id="6198.A0A075A0C3"/>
    <dbReference type="GeneID" id="20316368"/>
    <dbReference type="KEGG" id="ovi:T265_02180"/>
    <dbReference type="CTD" id="20316368"/>
    <dbReference type="OrthoDB" id="6238558at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19068" checksum="517C8B008729E004" modified="2014-10-01" version="1">MATDTVHNSAAPTIRKVLIPISSKLRMINVFDWYLSHAKQDGDYLIFVHTIKPNKFAKNLSLPMLIGTTMKISASSVEDGKHACRELMCLAKKNDLQAHSYMYVDSDLNAALRKAIKELKPDAVLINRLRFGALKNSTANDIVGFRKNTFSCTCDVCSSQKEQMTLLQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0W4</accession>
    <name>A0A075A0W4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_00683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162796.1">
        <property type="nucleotide sequence ID" value="XM_009164532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0W4"/>
    <dbReference type="STRING" id="6198.A0A075A0W4"/>
    <dbReference type="GeneID" id="20314871"/>
    <dbReference type="KEGG" id="ovi:T265_00683"/>
    <dbReference type="CTD" id="20314871"/>
    <dbReference type="OrthoDB" id="9046662at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704471" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="449" mass="50761" checksum="7BC3DC06EA4AF7FE" modified="2014-10-01" version="1">MMPNALQLSVVFTHILSTCLARREASISVNGCSTKNQYNTLQNITCDVAKDIFAVKFIILFLYCLIAFVGLVGNILVVWVVSRTKSIQTITNIFIANLAVSDILMCLVATPFTPVSLYMESWTLPEAVCKLLPITMAVSVYVSTLTSMAIALDRFFVIVHPFIPRMRIWLCFFIIITIWVVAVLISLPLAVYHRKQSNDHGRVWTCQEHWPKESSREVFTIVSFFLQFIVPCAIISVCYFRISLILRKRLRNKIGSGTKLRLQAENEIRRKKRTNSILIAMVAIFVICWIPLNVLLTAMDILSEVRIQTLLGPQYFTLVFFVCHLCGMSSAVYNPFLYAWMNENFKREVHRILPCFCSQAGQTHNTQQQTAGAEYTALATNGRQLTIPNPSFAEQPVQLCMNPINCVGETWTDERSVVRTELRASEASVKCSTFSTSEERIMAATNASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A260</accession>
    <name>A0A075A260_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174768.1">
        <property type="nucleotide sequence ID" value="XM_009176504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A260"/>
    <dbReference type="GeneID" id="20324369"/>
    <dbReference type="KEGG" id="ovi:T265_10201"/>
    <dbReference type="CTD" id="20324369"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8516" checksum="E2C81CDB93C1CBDB" modified="2014-10-01" version="1">MTQHDGRMRQCVKTPRTDCVYGCVRQDGGKINAALELLELTSKRNGIQAKLKCEEEWFAKKKSADWHWPVVPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2I7</accession>
    <name>A0A075A2I7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_03657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166463.1">
        <property type="nucleotide sequence ID" value="XM_009168199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2I7"/>
    <dbReference type="STRING" id="6198.A0A075A2I7"/>
    <dbReference type="GeneID" id="20317844"/>
    <dbReference type="KEGG" id="ovi:T265_03657"/>
    <dbReference type="CTD" id="20317844"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="835"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="837"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="962" mass="102759" checksum="116D2834113854B7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A325</accession>
    <name>A0A075A325_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163594.1">
        <property type="nucleotide sequence ID" value="XM_009165330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A325"/>
    <dbReference type="GeneID" id="20315512"/>
    <dbReference type="KEGG" id="ovi:T265_01324"/>
    <dbReference type="CTD" id="20315512"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="18829" checksum="FA3DC3A5F40C0908" modified="2014-10-01" version="1">MYHWTRNPEPQIVGPAALAIHYYWTTVLKIHKDEEMLDSRNSKAPCQRVAKLRVECAKEAVSNHVPHCRSERKNPSPDQGVPIRQIIPGENRFDLLSSSAGLNWSSSRFRLGTTPVSDLRQRPPRCSCESMSTFCGRLEILEFQCQCPPNGCRRCQAVIVGLAPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3C9</accession>
    <name>A0A075A3C9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_01242</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163491.1">
        <property type="nucleotide sequence ID" value="XM_009165227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3C9"/>
    <dbReference type="STRING" id="6198.A0A075A3C9"/>
    <dbReference type="GeneID" id="20315430"/>
    <dbReference type="KEGG" id="ovi:T265_01242"/>
    <dbReference type="CTD" id="20315430"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF74">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER CG1090-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="357"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="749" mass="84143" checksum="6BF4C61916E05C7E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A456</accession>
    <name>A0A075A456_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163211.1">
        <property type="nucleotide sequence ID" value="XM_009164947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A456"/>
    <dbReference type="STRING" id="6198.A0A075A456"/>
    <dbReference type="GeneID" id="20326852"/>
    <dbReference type="KEGG" id="ovi:T265_12684"/>
    <dbReference type="CTD" id="20326852"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12210" checksum="384561A8D9741B54" modified="2014-10-01" version="1" fragment="single">MSWWREGSLRELTVGHQVASQRYSIDKSDPRSWTLVIRNVTPSDAGNYICQINLSKLKEKFYRLSVLRTFKENHALETTKQDSTKLNDEYVKDEATPYKNMSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4R8</accession>
    <name>A0A075A4R8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162911.1">
        <property type="nucleotide sequence ID" value="XM_009164647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4R8"/>
    <dbReference type="GeneID" id="20314963"/>
    <dbReference type="KEGG" id="ovi:T265_00775"/>
    <dbReference type="CTD" id="20314963"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6924" checksum="DA4844455176AE96" modified="2014-10-01" version="1">MRVLALASIVPHVENIKSSATSFIHLCLSATDRKDQNRPGKLGQLPGSCFRIGNLKSWTAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5E9</accession>
    <name>A0A075A5E9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_02866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165474.1">
        <property type="nucleotide sequence ID" value="XM_009167210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5E9"/>
    <dbReference type="STRING" id="6198.A0A075A5E9"/>
    <dbReference type="GeneID" id="20317054"/>
    <dbReference type="KEGG" id="ovi:T265_02866"/>
    <dbReference type="CTD" id="20317054"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005859">
        <property type="term" value="C:muscle myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF33">
        <property type="entry name" value="MYOSIN LIGHT CHAIN ALKALI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0518">Myosin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="230" mass="25872" checksum="997D5F2EEA1A2ED4" modified="2014-10-01" version="1">MSYLVTDNSDTSTLVINSLFFQSSLSKSEIEDIREVFDLFDFWDGRDGMVDANKVGDLLRCSGMNPTVSVTVKHGATEKPGEKQYKFEEFLPCYEAILKEKAAGTFADYMEAFKTFDREGQGIVSAAEMRHVLTGYGEKLKEDQVDQILKFIDLREDLEGNVKYEVIPRCLHLQTLIQATWIETDNKMAVDTGYKIYLAVSPTKRNEDHAVPILEGPGLAISLSWAADYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5U2</accession>
    <name>A0A075A5U2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 9">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_09173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19890"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 9"/>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173448.1">
        <property type="nucleotide sequence ID" value="XM_009175184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5U2"/>
    <dbReference type="STRING" id="6198.A0A075A5U2"/>
    <dbReference type="GeneID" id="20323352"/>
    <dbReference type="KEGG" id="ovi:T265_09173"/>
    <dbReference type="CTD" id="20323352"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="506" mass="56758" checksum="028BB7EE0734E29D" modified="2014-10-01" version="1">MVASASQHFKELTLKDADAALSAELHRLVEAIPDGEARKREAFRKQMDGFHKLFQRYLDSTSDVFEWEKVEPVPKDFVKTYASLVTQEDKEMLRQELQKLVVVKLNGGLGTTMGCTGPKSLISVRNELTFLDLTIQQIEGLNREYNVNIPLVLMNSFNTNADTEKVLRKYQKMNVQILTFMQSMYPRLNRESLLPLAKCAFDPNEKPSNEGQLRGEHWYPPGHGDFYRSFVESGLAEKLSAEGKEWVFLSNIDNLGATVDLHILHFLLTSPLLPQFAMEVTDKTSADVKGGTLTNYQGHLRLLELAQVPKEHQDEFASVRTFRIFNTNNLWVKLPVMVDLVKKDTIQMEVIVNPKTLDSGLNILQLEQAAGAAVRSFDVALGINVPRSRFLPVKTTSDLLMVMSNLYVLDGGRLTLSPLRSFPSVPLVKLGSHFKKVKDFLTRFASIPDMLELDHLTVAGDVYFGKGITLRGTVIIIANVGSLINIPSGAIFENKIVSGNLRILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6Q0</accession>
    <name>A0A075A6Q0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596864">
        <property type="protein sequence ID" value="KER23114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173143.1">
        <property type="nucleotide sequence ID" value="XM_009174879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6Q0"/>
    <dbReference type="GeneID" id="20328874"/>
    <dbReference type="KEGG" id="ovi:T265_14708"/>
    <dbReference type="CTD" id="20328874"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="39" mass="4677" checksum="79140C93DA16AA5A" modified="2014-10-01" version="1" fragment="single">MHCTGGALKQLIRLPFSSRLRLDQLTFVTQHERRREPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A730</accession>
    <name>A0A075A730_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164716.1">
        <property type="nucleotide sequence ID" value="XM_009166452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A730"/>
    <dbReference type="GeneID" id="20316436"/>
    <dbReference type="KEGG" id="ovi:T265_02248"/>
    <dbReference type="CTD" id="20316436"/>
    <dbReference type="OrthoDB" id="10575956at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10381" checksum="0991C571B08BAEC1" modified="2014-10-01" version="1">MPSVLAKLRETGRVLVCQSEKGHYSHICFSRWQQIAILPNSSATNCYTSREGLPYFRRALRLPNSSSVSRRLTGSRSYRNFDNLRLCSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A768</accession>
    <name>A0A075A768_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00056</name>
        <name evidence="2" type="ORF">T265_00057</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161977.1">
        <property type="nucleotide sequence ID" value="XM_009163713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009161978.1">
        <property type="nucleotide sequence ID" value="XM_009163714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A768"/>
    <dbReference type="GeneID" id="20314244"/>
    <dbReference type="GeneID" id="20314245"/>
    <dbReference type="KEGG" id="ovi:T265_00056"/>
    <dbReference type="KEGG" id="ovi:T265_00057"/>
    <dbReference type="CTD" id="20314244"/>
    <dbReference type="CTD" id="20314245"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11831" checksum="AFC6E8F4EB71683C" modified="2014-10-01" version="1" fragment="single">VRDIAVCFHRGNYSQGCWKPVDSPRRFRLSWGSSAVRPVRPGVLTIRYDHARCWHGHHCSAEYFQACEQPRVEVPCGIRPKTTRRMLCFDASRQTRTFLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7B8</accession>
    <name>A0A075A7B8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596853">
        <property type="protein sequence ID" value="KER23344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172909.1">
        <property type="nucleotide sequence ID" value="XM_009174645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7B8"/>
    <dbReference type="GeneID" id="20322935"/>
    <dbReference type="KEGG" id="ovi:T265_08756"/>
    <dbReference type="CTD" id="20322935"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11320" checksum="02CDEC10CCE78FFB" modified="2014-10-01" version="1">MTTYTSVALSGAECCRLDLRARDKIDLTQSWTSVTKEVSEIPIQTYFLFVLLRAPMVVSVAVLTMICRPSVYAHWIMRGRPVRKVSAEYHKREIQLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9F2</accession>
    <name>A0A075A9F2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596635">
        <property type="protein sequence ID" value="KER32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163911.1">
        <property type="nucleotide sequence ID" value="XM_009165647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9F2"/>
    <dbReference type="STRING" id="6198.A0A075A9F2"/>
    <dbReference type="GeneID" id="20315776"/>
    <dbReference type="KEGG" id="ovi:T265_01588"/>
    <dbReference type="CTD" id="20315776"/>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10222" checksum="A5EF90834C8662B2" modified="2014-10-01" version="1">MNLLTGPNCPYEKLNAIRDQQEDLMRLHFEQDKKMQALIESGSRRGRKPVQSLISEEGWKTTKSNVDALITKLEALSSDIHNLHKPGHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9P3</accession>
    <name>A0A075A9P3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_12811"/>
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    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11069" checksum="2A42C8CD5F2DC258" modified="2014-10-01" version="1" fragment="single">LLKTPRQPTTCFALVEAHQVGAVPEFSSTLCLQISRLKLEAAWSNTFSCLETSEPRDSAGFQVNLSINQISLEATECAAPGHLMFQSLRYSKYRDTCISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9S1</accession>
    <name>A0A075A9S1_OPIVI</name>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704558" description="Polyketide cyclase/dehydrase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19055" checksum="F31A61A7E149037D" modified="2014-10-01" version="1">MKVLLAIFVLAVAVLSRLSISSDGSLASREAVIALTPDQCYQRLTDIASFPQWMISVQAVGGSHIPIKPKVGQHFVITTDWGFLGTIDQDVHVVKADGKRNFAYDVENWIGTHVEADVDQLGERQSKIRLTVSSRVKNPLQKYLIHPFARLYYSNWLTHSLLNFQLRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAK2</accession>
    <name>A0A075AAK2_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER24594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009173399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAK2"/>
    <dbReference type="GeneID" id="20321966"/>
    <dbReference type="KEGG" id="ovi:T265_07787"/>
    <dbReference type="CTD" id="20321966"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14884" checksum="19A0600F543D822A" modified="2014-10-01" version="1">MTIFGIENIDIPKEINLTAHFVGMQQLGGVRTITESRKDRDSEQRVENDELQQFDVVKIPGKYELDEGMIGQLNGRRYTATTYLEEQCRTNSVLTALSTIIPKKELAIGYVNVAFKNNLSTNTSHFRMSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABG6</accession>
    <name>A0A075ABG6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_00848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009164743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABG6"/>
    <dbReference type="STRING" id="6198.A0A075ABG6"/>
    <dbReference type="GeneID" id="20315036"/>
    <dbReference type="KEGG" id="ovi:T265_00848"/>
    <dbReference type="CTD" id="20315036"/>
    <dbReference type="OrthoDB" id="6272564at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034243">
        <property type="term" value="P:regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047269">
        <property type="entry name" value="ZMY11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46379:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="742"/>
        </location>
    </feature>
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        <location>
            <begin position="743"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="923" mass="101275" checksum="CCDFA9A89BB99534" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACU7</accession>
    <name>A0A075ACU7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_00289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162298.1">
        <property type="nucleotide sequence ID" value="XM_009164034.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A075ACU7"/>
    <dbReference type="STRING" id="6198.A0A075ACU7"/>
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    <dbReference type="KEGG" id="ovi:T265_00289"/>
    <dbReference type="CTD" id="20314477"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="307"/>
            <end position="335"/>
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    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
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        <location>
            <begin position="545"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1093" mass="118177" checksum="86B47BE0A90DC3B0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AE49</accession>
    <name>A0A075AE49_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_06286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26499.1"/>
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        <property type="nucleotide sequence ID" value="XM_009171506.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20320468"/>
    <dbReference type="KEGG" id="ovi:T265_06286"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="96" mass="10514" checksum="5856D0EA97BD2123" modified="2014-10-01" version="1">MALQSRLQVISGFAYIIPSAQYVYHLIMTPYGLCIVDCSGMARTLSALNERSSVEGGKLGVQFTGRPKTTLDGNVVDPLYLHSNVSGAPFHLRLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AED8</accession>
    <name>A0A075AED8_OPIVI</name>
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        <recommendedName>
            <fullName evidence="11">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171337.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A075AED8"/>
    <dbReference type="GeneID" id="20320326"/>
    <dbReference type="KEGG" id="ovi:T265_06144"/>
    <dbReference type="CTD" id="20320326"/>
    <dbReference type="OrthoDB" id="6249511at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="8">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46318" checksum="641F1D0D7A25A7DC" modified="2014-10-01" version="1">MTGLLFIRRPGLTTNYFKENNCISPLPDRTLALESFPIHTTLTQLRRFISIIGYYHRFIPHYADILKPLTDLLGSKEKSVTLLPAAIAAFERAKQAIAQATKLSFLDTHKSTKLILTTDASNAAVPPALHQVVNNTSQPPAIFPQKMQAAQTRYSTFGREVLVIYLAIRHLRHLLEGRSFTVQTDHKPLTYAFNAKPDRCSPREIRHLDYKSQFTTDIRYAPGPENVVADALSRLDINALHPSTQLDLAKLANLQNSDPNFLPILSFPSFQVSSIPLALQSGTMFCDMSTGSARPIVPEAFRLVVFDHFHGFSHPGIRATRKFISARFVWPFMNKDVTSWAKQCIACQRTKFFLEAKIFQLEDVKHHEVRSMVPGFEASNHFLSSSPDTLNGGHVLRGSRTIQEAVWRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFS1</accession>
    <name>A0A075AFS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">XPG protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_13666</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168211.1">
        <property type="nucleotide sequence ID" value="XM_009169947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFS1"/>
    <dbReference type="STRING" id="6198.A0A075AFS1"/>
    <dbReference type="GeneID" id="20327833"/>
    <dbReference type="KEGG" id="ovi:T265_13666"/>
    <dbReference type="CTD" id="20327833"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="694"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER28039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121267" checksum="86FCDBBBA7500CE2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGX5</accession>
    <name>A0A075AGX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167095.1">
        <property type="nucleotide sequence ID" value="XM_009168831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGX5"/>
    <dbReference type="GeneID" id="20318347"/>
    <dbReference type="KEGG" id="ovi:T265_04161"/>
    <dbReference type="CTD" id="20318347"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13441" checksum="5FACD13040652800" modified="2014-10-01" version="1">MAASQTISTLETLTLSFTLPPPKHSPIDSNEQVIGKRQILSATWNFVSQQCLGTLQHTGSGPQSQLGPHHDRINMANSGNTRFGNPDPVIPTCETSKEKCGIDLHNGSYTIPLQVTDIHFCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHN4</accession>
    <name>A0A075AHN4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 9">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_03344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>L-histidine = trans-urocanate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 9"/>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166069.1">
        <property type="nucleotide sequence ID" value="XM_009167805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHN4"/>
    <dbReference type="STRING" id="6198.A0A075AHN4"/>
    <dbReference type="GeneID" id="20317531"/>
    <dbReference type="KEGG" id="ovi:T265_03344"/>
    <dbReference type="CTD" id="20317531"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000005">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000003">
        <property type="entry name" value="Histidine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006871">
        <property type="entry name" value="PRK09367.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="663" mass="72923" checksum="2C9D6A5534EA85F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHZ3</accession>
    <name>A0A075AHZ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_13112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="KL596656">
        <property type="protein sequence ID" value="KER30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165529.1">
        <property type="nucleotide sequence ID" value="XM_009167265.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AHZ3"/>
    <dbReference type="GeneID" id="20327280"/>
    <dbReference type="KEGG" id="ovi:T265_13112"/>
    <dbReference type="CTD" id="20327280"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141050">
        <property type="term" value="F:histone H3K deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="869"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="16">
        <location>
            <begin position="198"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1242"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1694" mass="185849" checksum="05E12C7D1A5158E5" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIZ8</accession>
    <name>A0A075AIZ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596633">
        <property type="protein sequence ID" value="KER32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163677.1">
        <property type="nucleotide sequence ID" value="XM_009165413.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AIZ8"/>
    <dbReference type="GeneID" id="20315575"/>
    <dbReference type="KEGG" id="ovi:T265_01387"/>
    <dbReference type="CTD" id="20315575"/>
    <dbReference type="OrthoDB" id="1910803at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="676"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1365" mass="153229" checksum="F66339F5D4F593C6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU32</accession>
    <name>A0A074YU32_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605830">
        <property type="protein sequence ID" value="KER18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178030.1">
        <property type="nucleotide sequence ID" value="XM_009179766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU32"/>
    <dbReference type="STRING" id="6198.A0A074YU32"/>
    <dbReference type="GeneID" id="20326502"/>
    <dbReference type="KEGG" id="ovi:T265_12334"/>
    <dbReference type="CTD" id="20326502"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="33" mass="4087" checksum="F7AF091D9EE1B305" modified="2014-10-01" version="1" fragment="single">WSAWSSLSRCLPRDCGLTRYRWRRRRCLNSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUZ8</accession>
    <name>A0A074YUZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599340">
        <property type="protein sequence ID" value="KER18596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177657.1">
        <property type="nucleotide sequence ID" value="XM_009179393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUZ8"/>
    <dbReference type="STRING" id="6198.A0A074YUZ8"/>
    <dbReference type="GeneID" id="20326389"/>
    <dbReference type="KEGG" id="ovi:T265_12221"/>
    <dbReference type="CTD" id="20326389"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="45" mass="4664" checksum="54C2A23C656D8F85" modified="2014-10-01" version="1" fragment="single">VQSVDTPARRASGPLPPPLPPRSNSRNQLGPQCGVISRPGLCTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YV97</accession>
    <name>A0A074YV97_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599240">
        <property type="protein sequence ID" value="KER18608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177645.1">
        <property type="nucleotide sequence ID" value="XM_009179381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YV97"/>
    <dbReference type="GeneID" id="20326387"/>
    <dbReference type="KEGG" id="ovi:T265_12219"/>
    <dbReference type="CTD" id="20326387"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10015" checksum="F55FFCCCC490A79D" modified="2014-10-01" version="1">MAHELTHQPPVCEILLLVFHGCPAKILICLCFCDSNFMHYVFVTLWGDDHFPLPTSLVFILLSLSVIFSRPPPRSPSSPHTCMLCMCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWT3</accession>
    <name>A0A074YWT3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597316">
        <property type="protein sequence ID" value="KER19133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177117.1">
        <property type="nucleotide sequence ID" value="XM_009178853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWT3"/>
    <dbReference type="GeneID" id="20326155"/>
    <dbReference type="KEGG" id="ovi:T265_11987"/>
    <dbReference type="CTD" id="20326155"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="312" mass="36004" checksum="E40DA8C1C087340C" modified="2014-10-01" version="1">MDIVLVSHHDAYTYAPKCQRTFVICRTHIFRPIHLQKVGKQCLPACPRREPKPWRSLFTSLTAAGESLTGKHQVGFRLGRGCIAHICSLRQLGFMNAFDSCSHQFCQPHLPQKFVNIIRRLYSHLESVHLRVYGEFSRRFLTKSTILLPCLTSSSMQYCKASPFYVVRHNVEVGKQCLPACPRREPKPWRSLFTSLTAAGESLTGKHQVGFRLGRGCIAHICSLRQLGFMNAFDSCSHQFCQPHLPQKFVNIIRRLYSHLESVHLRVYGEFSRRFLTKSTILLPCLTSSSMQCWCEHRKFSNIRQLCWESCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWU2</accession>
    <name>A0A074YWU2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597266">
        <property type="protein sequence ID" value="KER19261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176989.1">
        <property type="nucleotide sequence ID" value="XM_009178725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWU2"/>
    <dbReference type="STRING" id="6198.A0A074YWU2"/>
    <dbReference type="GeneID" id="20326071"/>
    <dbReference type="KEGG" id="ovi:T265_11903"/>
    <dbReference type="CTD" id="20326071"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF114">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="680" mass="76478" checksum="06C3ED8F4F03DBB8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY31</accession>
    <name>A0A074YY31_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597158">
        <property type="protein sequence ID" value="KER19671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176584.1">
        <property type="nucleotide sequence ID" value="XM_009178320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY31"/>
    <dbReference type="GeneID" id="20329645"/>
    <dbReference type="KEGG" id="ovi:T265_15480"/>
    <dbReference type="CTD" id="20329645"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="24998" checksum="2FB71E58CDC074C5" modified="2014-10-01" version="1" fragment="single">GDGVHKSSSRQADQHPNHSHSIRASPGLAHSAVITYTPMNIQMSSLTYRTKFQQKSRTFPNHKHRFQSPAVCMNSSISNLESSPMCFNFGARKCGGTKRSPTYALRSGIYALIAAADSGLLQPSLTTLPPVVTSNYFKHMPSQLYFMYPYLPYPFFPSTELHLYEVTKFSINMLCTPMDLSVMLFNALLLLAKDHTFLAIVAVAQPSLICVTETWLSVETPETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ30</accession>
    <name>A0A074YZ30_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597100">
        <property type="protein sequence ID" value="KER20051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176204.1">
        <property type="nucleotide sequence ID" value="XM_009177940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZ30"/>
    <dbReference type="GeneID" id="20325483"/>
    <dbReference type="KEGG" id="ovi:T265_11315"/>
    <dbReference type="CTD" id="20325483"/>
    <dbReference type="OrthoDB" id="10272604at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10508" checksum="9CF7259C4D96E685" modified="2014-10-01" version="1">MARSDWSAVALTTDSSKLIGTGLATAEDVIALMCAFVDIKATDFDTDWQEELAELIYEAACRSVSSRRTPAYLERQLRLRFGPGWTAMVSDDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZP3</accession>
    <name>A0A074YZP3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_11152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KL597074">
        <property type="protein sequence ID" value="KER20246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175998.1">
        <property type="nucleotide sequence ID" value="XM_009177734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZP3"/>
    <dbReference type="STRING" id="6198.A0A074YZP3"/>
    <dbReference type="GeneID" id="20325320"/>
    <dbReference type="KEGG" id="ovi:T265_11152"/>
    <dbReference type="CTD" id="20325320"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="604" mass="68795" checksum="B5598C8093AD7A32" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZQ9</accession>
    <name>A0A074YZQ9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597072">
        <property type="protein sequence ID" value="KER20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175975.1">
        <property type="nucleotide sequence ID" value="XM_009177711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZQ9"/>
    <dbReference type="STRING" id="6198.A0A074YZQ9"/>
    <dbReference type="GeneID" id="20329520"/>
    <dbReference type="KEGG" id="ovi:T265_15355"/>
    <dbReference type="CTD" id="20329520"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="3">
        <location>
            <begin position="422"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1173" mass="128631" checksum="A7FB3C8624E4F058" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0C9</accession>
    <name>A0A074Z0C9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597050">
        <property type="protein sequence ID" value="KER20496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175753.1">
        <property type="nucleotide sequence ID" value="XM_009177489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0C9"/>
    <dbReference type="GeneID" id="20329469"/>
    <dbReference type="KEGG" id="ovi:T265_15304"/>
    <dbReference type="CTD" id="20329469"/>
    <dbReference type="OrthoDB" id="6240724at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703708" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="24727" checksum="73B3E6ED08CE7D86" modified="2014-10-01" version="1" fragment="single">MIYVWSVLALCCITVIFPASAGVAGVRVAAPNVWANNPYVVSSNYPQLSLMQTSLSNEKQGQMDQLSLQRLAQLQSATGGQQLTPMYASTGSAFVAPAGYLPQAAYILGSQPTGQGTYMVASDSNPSLLSVSTSNGATSGNEVISSSNTKATSATSGTAVVGSPTDGVIGADGQILGSTQDTAVVESAGQLGPTVVRADIPVTYQQDSLIPYQSQQLLYTQGRRLFGVDEYGRPVYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0I6</accession>
    <name>A0A074Z0I6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175788.1">
        <property type="nucleotide sequence ID" value="XM_009177524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0I6"/>
    <dbReference type="GeneID" id="20325159"/>
    <dbReference type="KEGG" id="ovi:T265_10991"/>
    <dbReference type="CTD" id="20325159"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15257" checksum="1619C2FCBE28F4B1" modified="2014-10-01" version="1">MKDFVCVTYVRFDVHTEVCSLVRNSATMREVTCSSASVSWCKNWELRTTGHINRSHSRIHRGHSSLRTSHIVSMNWKQVQVLPPLLVSITATSPIPVSLVSSSTKACLPDCDSNFKASPLTSREVKFSSSRMPFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0V3</accession>
    <name>A0A074Z0V3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597035">
        <property type="protein sequence ID" value="KER20646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175605.1">
        <property type="nucleotide sequence ID" value="XM_009177341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0V3"/>
    <dbReference type="GeneID" id="20325022"/>
    <dbReference type="KEGG" id="ovi:T265_10854"/>
    <dbReference type="CTD" id="20325022"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14953" checksum="5FF39C7045CA8D9D" modified="2014-10-01" version="1">MPTAQGVGKGNATGRGILETKVSRCYLPGFSFVEGKHYRLGTLTVMDRDRAHMTDVNVSTGIIHADHTSNGRRQYSHSFQSVVTGRQLEPIRHLRNINNKRSIKETTHKVAENPSTAYDRFRPFWGSSGRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1M6</accession>
    <name>A0A074Z1M6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">BCS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_10613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597007">
        <property type="protein sequence ID" value="KER20956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175299.1">
        <property type="nucleotide sequence ID" value="XM_009177035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1M6"/>
    <dbReference type="STRING" id="6198.A0A074Z1M6"/>
    <dbReference type="GeneID" id="20324781"/>
    <dbReference type="KEGG" id="ovi:T265_10613"/>
    <dbReference type="CTD" id="20324781"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER20956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="486" mass="54266" checksum="7F6FE1C94E9D265E" modified="2014-10-01" version="1">MESIQLVLESALKDNPYFSAGAGLFGVGLGVAMLRRMGQLSRIILRRNFTQTLEVASNDKAYPWVLHWISTRASTNASHDASQQSWFGRRPGGPNQHLSVETNVVRTEGGRIRVAFDFVPSTGVHYMFHRRRLIRIERVRAQQTMQGASVAPFESVTLTTFGRNTQLFIDLLEEAREAAVARETGWTVVYKALGSDWRQFGYPRPRRPLDSVVLRKGVAEALVADVREFIENQAWYTERGIPYHRGYLLYGPPGCGKTSFITALAGHLDYSISVLNLSEFGMTADRLDHLLTHAPLQSIVLLEDIDAAVHSRQGTVTQSKAYEGMPTLTLSGLLNALDGVTSTDGRIIFMTTNYVDRLDPALIRPGRVDLKVHVDYCDRYQLERMFSRFYPIPGRPPKLSPDADWRGLDEKSKMEPMTSMEELHPLAAKFADSLVGVAVSSAQIQGYLLTYKEDAAGALANIDLLRRAGVNRNELKRSSEQSFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2P5</accession>
    <name>A0A074Z2P5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597140">
        <property type="protein sequence ID" value="KER19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176476.1">
        <property type="nucleotide sequence ID" value="XM_009178212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2P5"/>
    <dbReference type="GeneID" id="20325701"/>
    <dbReference type="KEGG" id="ovi:T265_11533"/>
    <dbReference type="CTD" id="20325701"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10115" checksum="EDE689420CDFD1D4" modified="2014-10-01" version="1" fragment="single">WHSHCSCQQKACLVVHQPTSILPHIGIKVSNVMPHLAPRKRSVVSRTAIAQPLLTCGSASNISHTCAMPSQTRVICLLCTTLWRSVRRPAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3J3</accession>
    <name>A0A074Z3J3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596955">
        <property type="protein sequence ID" value="KER21598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174653.1">
        <property type="nucleotide sequence ID" value="XM_009176389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3J3"/>
    <dbReference type="GeneID" id="20324282"/>
    <dbReference type="KEGG" id="ovi:T265_10114"/>
    <dbReference type="CTD" id="20324282"/>
    <dbReference type="OrthoDB" id="6287939at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12343" checksum="C486A437BCB8B4B3" modified="2014-10-01" version="1">MARAVCRHRPPGDLLCNSRWSGSKVVNRNQLPKRRDTQEERPSRSSAEADMTEPSLAIDLPADKERMTVIMDKSDYVDKAKALLNDTTTYRRLENDQTKKLKRLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z464</accession>
    <name>A0A074Z464_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_11111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597069">
        <property type="protein sequence ID" value="KER20302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175941.1">
        <property type="nucleotide sequence ID" value="XM_009177677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z464"/>
    <dbReference type="STRING" id="6198.A0A074Z464"/>
    <dbReference type="GeneID" id="20325279"/>
    <dbReference type="KEGG" id="ovi:T265_11111"/>
    <dbReference type="CTD" id="20325279"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="251" mass="28092" checksum="7B9D7F828FEE59FC" modified="2014-10-01" version="1">MSGKVDDLYLPNAVILRIIRDSLPDRTVVSREARSAISKAASSFILYVTSLASTHCEAAKRKTLAVGDILAALKDMQFEHYIVELQTFLERKLAEIALGTQLGARWTKWLKREFTDRKVRGSNPTSASRLPLSRLGRPGSIPALVLPSCGMAARHRKRATVGTLTQLDHSHRTPATSFSIYWCARWPKWLQREFTDRKVRGSNPTSASRLPCLGLGNLAVSQLSCFLRLAWRLGTKRVLLLNGSIYWSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4N7</accession>
    <name>A0A074Z4N7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596924">
        <property type="protein sequence ID" value="KER22028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174219.1">
        <property type="nucleotide sequence ID" value="XM_009175955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4N7"/>
    <dbReference type="GeneID" id="20323949"/>
    <dbReference type="KEGG" id="ovi:T265_09781"/>
    <dbReference type="CTD" id="20323949"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="230" mass="25996" checksum="564C786708AEA4A8" modified="2014-10-01" version="1">MNEIEGSGLRRSLNSFTSNLDGSEMWAPWQYPSPRTTMNCTYTNKLVSHRPSRGAIIRVTLLAAYSKAGKRKHATADASLLSLSHTFSSPFLHPINNPPLLDDYCIHHSAVIPFRCLTATRPDESTKAEILPGFQRSDRSRRHSEVALDNGPFGQKVLTLNTETYQAAYNTSNYVRLLKIRRQFTTGFALLEAHQIDAVPEFPSTLFYLKPNCMKLAKYPHLQTNFVYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z510</accession>
    <name>A0A074Z510_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601743">
        <property type="protein sequence ID" value="KER18405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177848.1">
        <property type="nucleotide sequence ID" value="XM_009179584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z510"/>
    <dbReference type="GeneID" id="20330245"/>
    <dbReference type="KEGG" id="ovi:T265_16080"/>
    <dbReference type="CTD" id="20330245"/>
    <dbReference type="OrthoDB" id="6234035at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703957" evidence="1">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="293" mass="33172" checksum="696E39D44C7B1617" modified="2014-10-01" version="1" fragment="single">MIVSFKWSILFNLIITLSEAVIKLCPNTVGPHPRPDNLTCYYERVQQAIKRHQLHIVGLSGNPQKLFLDCPVCPNENVEDFEWLFVTRARSAPIYEAGPTYYYGSNYVLKKDVTGLVPDVDEGDLCMIESTNDLYVYDAAKIQLLHGTYVCRYKPEESHPANFIWHEVDTVHDLGVIKIQSPNVPDSTKVESYEQLMQLQQLVKKDLIAHQGAPDLTIGPFVVTSQILEGDILIGACGPLRVKQRKNCYVQLPTEEPDFANKTDEMYAYRVLRDAFDFLVSGPGYTDKGGQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z543</accession>
    <name>A0A074Z543_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596911">
        <property type="protein sequence ID" value="KER22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174033.1">
        <property type="nucleotide sequence ID" value="XM_009175769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z543"/>
    <dbReference type="STRING" id="6198.A0A074Z543"/>
    <dbReference type="GeneID" id="20323807"/>
    <dbReference type="KEGG" id="ovi:T265_09639"/>
    <dbReference type="CTD" id="20323807"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="287" mass="32196" checksum="21BDD2BD2F80ACEF" modified="2014-10-01" version="1">MLQKIPQLTYEKASDGAFENLNRNAIQWNWFRKIEDHPSSGNTQLKWLLICTPSLAIDLQTFGHHSRRHLQCAVGWSSLCAVTWIPIGPFLICMASWSASVLVCGGPFSPSWEIGESSQGVIGITLNMGIKRKALQIYMYRDISNIVATETWGSPVQHIQLPGNITNERFSWVPVASTFIGLTSPDYKPPGPMTKALDRDGARLPKWLEREFTDWKVRGSNPTSASRLPLSKFGQPGSIPDPLVQPGSIAALVLPSGDMADRHRKSVRAERFHFISILKFILYRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z587</accession>
    <name>A0A074Z587_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formyl transferase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596907">
        <property type="protein sequence ID" value="KER22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173947.1">
        <property type="nucleotide sequence ID" value="XM_009175683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z587"/>
    <dbReference type="STRING" id="6198.A0A074Z587"/>
    <dbReference type="GeneID" id="20323742"/>
    <dbReference type="KEGG" id="ovi:T265_09573"/>
    <dbReference type="CTD" id="20323742"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="252"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="535" mass="58770" checksum="A49974FBBFD54FE1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5T4</accession>
    <name>A0A074Z5T4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL599119">
        <property type="protein sequence ID" value="KER18625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177628.1">
        <property type="nucleotide sequence ID" value="XM_009179364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5T4"/>
    <dbReference type="GeneID" id="20330097"/>
    <dbReference type="KEGG" id="ovi:T265_15932"/>
    <dbReference type="CTD" id="20330097"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001703930" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11403" checksum="E8BD3D31FF848D9C" modified="2014-10-01" version="1" fragment="single">MFTFFLLALLTVSCRAKLFQMTRFNSTVVTVTQRMSDADKYDEQPLCAQLITKHIGVWAKSEKLSKCVLRQVQNGYPIFHVNLNATRIPEGYQEKANLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z725</accession>
    <name>A0A074Z725_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_10281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596971">
        <property type="protein sequence ID" value="KER21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174870.1">
        <property type="nucleotide sequence ID" value="XM_009176606.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z725"/>
    <dbReference type="GeneID" id="20324449"/>
    <dbReference type="KEGG" id="ovi:T265_10281"/>
    <dbReference type="CTD" id="20324449"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000481">
        <property type="entry name" value="Asator, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000358">
        <property type="entry name" value="Tau tubulin kinase 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="869"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1330" mass="143884" checksum="B4A54C8E1F0A9C3A" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7L2</accession>
    <name>A0A074Z7L2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597295">
        <property type="protein sequence ID" value="KER19190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177060.1">
        <property type="nucleotide sequence ID" value="XM_009178796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7L2"/>
    <dbReference type="STRING" id="6198.A0A074Z7L2"/>
    <dbReference type="GeneID" id="20326120"/>
    <dbReference type="KEGG" id="ovi:T265_11952"/>
    <dbReference type="CTD" id="20326120"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="429" mass="48558" checksum="0B6483B52D3CD128" modified="2014-10-01" version="1">MEGSTVYSQNVSVILCFDGFLLLALCCLLGAAVALCSILLEDIWRRRGTIDPLRYIALSLDILSLPCTYCPEDPWFKPNPGIWTAPVWAWATPQYLSRRAPFWWRGSQTPKLATLILTERQRRCHQPRSETLFSYWLLLFLSVIPRIVGLIFSAANSVPTDLLETSFLPTSKRGLERIQLYALLVYMCSAFAHLLTQCFSPHNPSNSLLSDKSKRGLERIQLYALLVYMCSAFAHLLTQCFSPHNPSNSLLSDKCHWCRAAQTLYPGIEIALITIIDSISSLFNTDALLPYNHDLFESFIVKKRVKVYGGGTCLKLANAARALEIRAFASSVTLQPELIQHPRYVKRSSTSPWIVSGVFSDCMSTSMTSHFVGAKCLSKDGDDFGQFIQKHLRLLLLFKDENDVVRTFQIDKVFFTGYLNTRVLETFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8V5</accession>
    <name>A0A074Z8V5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172665.1">
        <property type="nucleotide sequence ID" value="XM_009174401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8V5"/>
    <dbReference type="GeneID" id="20322735"/>
    <dbReference type="KEGG" id="ovi:T265_08556"/>
    <dbReference type="CTD" id="20322735"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11395" checksum="66DB9EF8CB89E6E8" modified="2014-10-01" version="1">MMWVRRSDGLGKAYFDAMLQWVLKGINWTSEKNFPIAPGSLMDRLRSHVLRQCIQIKAVWPKEVDMGATADTTDETCEYVDLFVKLGNWLASILSSNQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z956</accession>
    <name>A0A074Z956_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597142">
        <property type="protein sequence ID" value="KER19760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176484.1">
        <property type="nucleotide sequence ID" value="XM_009178220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z956"/>
    <dbReference type="GeneID" id="20325708"/>
    <dbReference type="KEGG" id="ovi:T265_11540"/>
    <dbReference type="CTD" id="20325708"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="77" mass="8126" checksum="C489BB71AD415D48" modified="2014-10-01" version="1">MLLSFLALPGAPNREQSDALIPEVDIPSLPGCSLNDTVLDGQILVVVSSTPPCTYVVQSPNSKGPNNNLIHNPMLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9Z9</accession>
    <name>A0A074Z9Z9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9Z9"/>
    <dbReference type="STRING" id="6198.A0A074Z9Z9"/>
    <dbReference type="GeneID" id="20323652"/>
    <dbReference type="KEGG" id="ovi:T265_09483"/>
    <dbReference type="CTD" id="20323652"/>
    <dbReference type="OrthoDB" id="10467533at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1280" mass="139148" checksum="14AF38CD1419F1A4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAV8</accession>
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    <organism evidence="1 2">
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        <name type="common">Southeast Asian liver fluke</name>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="KEGG" id="ovi:T265_11071"/>
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    <dbReference type="OrthoDB" id="10615349at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KER20375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="175" mass="19299" checksum="373ADA6AA8135ED9" modified="2014-10-01" version="1">MCSLLSSVRGKPDAPTGVPIALLTCQGFPVSLNVLVCSHVKIHMRPGYAGGAVVTRSPRNSDVWSSQLGYNRSGTRGLETHQNLCSRTGGWLFKHDCCGRELTELFTRDSTESLVYDILQLNVLHTGRLMIHSSVAHIQWPCRALNPAYLTREASVLPLHHQHTLDLSGFLRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB48</accession>
    <name>A0A074ZB48_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB48"/>
    <dbReference type="GeneID" id="20322130"/>
    <dbReference type="KEGG" id="ovi:T265_07951"/>
    <dbReference type="CTD" id="20322130"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12026" checksum="2739BBDBE3EBCD45" modified="2014-10-01" version="1">MPSRIEGPQGLKRDSLKVCFGQRRFPTSLNRIYTNISWVPDRRSIVWRRFGFTGVFVGGQACAVTPSFIKWPSAVDPVQDTEGLTAISKWTDEDIFYNDVGIATVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB55</accession>
    <name>A0A074ZB55_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175790.1">
        <property type="nucleotide sequence ID" value="XM_009177526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB55"/>
    <dbReference type="STRING" id="6198.A0A074ZB55"/>
    <dbReference type="GeneID" id="20325161"/>
    <dbReference type="KEGG" id="ovi:T265_10993"/>
    <dbReference type="CTD" id="20325161"/>
    <dbReference type="OrthoDB" id="6249811at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="718" mass="82309" checksum="1CABC8D51AABAAA8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB72</accession>
    <name>A0A074ZB72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171720.1">
        <property type="nucleotide sequence ID" value="XM_009173456.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZB72"/>
    <dbReference type="GeneID" id="20328565"/>
    <dbReference type="KEGG" id="ovi:T265_14399"/>
    <dbReference type="CTD" id="20328565"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115590" checksum="8D245738AB4938FA" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBB3</accession>
    <name>A0A074ZBB3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_14769</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173408.1">
        <property type="nucleotide sequence ID" value="XM_009175144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBB3"/>
    <dbReference type="STRING" id="6198.A0A074ZBB3"/>
    <dbReference type="GeneID" id="20328935"/>
    <dbReference type="KEGG" id="ovi:T265_14769"/>
    <dbReference type="CTD" id="20328935"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER22867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="841" mass="91877" checksum="02E7B17CDD19476C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCB2</accession>
    <name>A0A074ZCB2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H2 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171306.1">
        <property type="nucleotide sequence ID" value="XM_009173042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCB2"/>
    <dbReference type="STRING" id="6198.A0A074ZCB2"/>
    <dbReference type="GeneID" id="20321684"/>
    <dbReference type="KEGG" id="ovi:T265_07505"/>
    <dbReference type="CTD" id="20321684"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="10">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="9">
        <location>
            <begin position="398"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="603" mass="65994" checksum="990200682D75C0D7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCV5</accession>
    <name>A0A074ZCV5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMS membrane protein/tumor differentially expressed protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171257.1">
        <property type="nucleotide sequence ID" value="XM_009172993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCV5"/>
    <dbReference type="STRING" id="6198.A0A074ZCV5"/>
    <dbReference type="GeneID" id="20321643"/>
    <dbReference type="KEGG" id="ovi:T265_07464"/>
    <dbReference type="CTD" id="20321643"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="91357" checksum="E5459202E8856211" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDE7</accession>
    <name>A0A074ZDE7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_07292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171043.1">
        <property type="nucleotide sequence ID" value="XM_009172779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDE7"/>
    <dbReference type="STRING" id="6198.A0A074ZDE7"/>
    <dbReference type="GeneID" id="20321471"/>
    <dbReference type="KEGG" id="ovi:T265_07292"/>
    <dbReference type="CTD" id="20321471"/>
    <dbReference type="OrthoDB" id="10249149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER25188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="451" mass="50302" checksum="C68AB477A7514DD5" modified="2014-10-01" version="1">MRECISVHVGQSGTQLGNASWELMCLEHGIQPDGQMPQDYTVGGGDDSFMCMFNETGAGKFVPRAVFIDLEPTVIDEIRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLVLDRVRKCADLCNGLQGFLVFHSFGGGTGSGFTSLLMERLCIDYGKRTKLEIAVYPAPQISTCVVEPYNAILNTHTTLDLTDCAFMVDNEAVYDVCRRNLDIERPTYTNVNRIVSQALSSITASLRFDGSLNVDLMEFQTNLVPYPRIHFPMCCYAPAISAEKAYHQNLDVQDITNQCFEPANQFVKCDPRHGKYMACCLLFRGDVVPKDVNAAIATIKSKRTIQFVDWCPTGFKVGINFQPPTAVPGGDLAKVQRAVCMLSNTTAIAEAWVRLDHKFDLMFAKRAFVHWYVGEGMEEGEFSEARENLAALEKDYEEVGTDSGEAESELEQEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDL3</accession>
    <name>A0A074ZDL3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596782">
        <property type="protein sequence ID" value="KER25263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170987.1">
        <property type="nucleotide sequence ID" value="XM_009172723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDL3"/>
    <dbReference type="GeneID" id="20321428"/>
    <dbReference type="KEGG" id="ovi:T265_07249"/>
    <dbReference type="CTD" id="20321428"/>
    <dbReference type="OrthoDB" id="6019958at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705067" evidence="1">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="148" mass="17369" checksum="6F43855B2DBAEA6D" modified="2014-10-01" version="1">MSVALVLSVSIQIARMNVGCVGLCSSPLLSVFEMQLTRLCLGRFIPWKCTPGATWGGKQRKIPRLTHARKSAFLGHMLLSEQNHRFLQNPCMTAEVEAATLEDERRRELEREDQVFYDRYATQFHNRFVSRRIEETWKRVLRRQRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE59</accession>
    <name>A0A074ZE59_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596776">
        <property type="protein sequence ID" value="KER25458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170784.1">
        <property type="nucleotide sequence ID" value="XM_009172520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE59"/>
    <dbReference type="GeneID" id="20321261"/>
    <dbReference type="KEGG" id="ovi:T265_07082"/>
    <dbReference type="CTD" id="20321261"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="14935" checksum="4A76018619EAA59A" modified="2014-10-01" version="1">MKQATDVSKDAYMGMLNEPDVHRTCYRHQLSSSNWLNSVQQNDSASGVSQKRNQSNTQFTKPDRYSSIPIDIIINLSPRSFDNRQKNKPVPTALDESHPNDDVRGEKNKLMEVYTCSLDAVCTQSCSGQSHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE95</accession>
    <name>A0A074ZE95_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172285.1">
        <property type="nucleotide sequence ID" value="XM_009174021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE95"/>
    <dbReference type="GeneID" id="20322452"/>
    <dbReference type="KEGG" id="ovi:T265_08273"/>
    <dbReference type="CTD" id="20322452"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="78" mass="8835" checksum="AADF30E098905EF7" modified="2014-10-01" version="1">MMFAVVPSNNPTTPIACRRQYAMYRGLVDNLLQPLVEIVPYCFGYLEGAAKYWDPDNEYVIGTAKYDNRNILNASAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEX5</accession>
    <name>A0A074ZEX5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172080.1">
        <property type="nucleotide sequence ID" value="XM_009173816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEX5"/>
    <dbReference type="GeneID" id="20322288"/>
    <dbReference type="KEGG" id="ovi:T265_08109"/>
    <dbReference type="CTD" id="20322288"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="67" mass="6800" checksum="A3BC7BBF0C1DFAFE" modified="2014-10-01" version="1">MHTILDGAAVGADYDTQLDEFEGVVQSAQHRNGYAVVFTEVAGASGQHDLFATAVAAAAVADAPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFF1</accession>
    <name>A0A074ZFF1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170325.1">
        <property type="nucleotide sequence ID" value="XM_009172061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFF1"/>
    <dbReference type="GeneID" id="20320903"/>
    <dbReference type="KEGG" id="ovi:T265_06724"/>
    <dbReference type="CTD" id="20320903"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="8731" checksum="CFD5D5AA9AF46D8F" modified="2014-10-01" version="1">MLHDSSVTSDGKSSQELCIVRAAVLIIGAGQDPKRTFLKMRSQPIGDKHSFGLILNPEELRRMCEPIVSLQADLATSKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFT0</accession>
    <name>A0A074ZFT0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596920">
        <property type="protein sequence ID" value="KER22095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174177.1">
        <property type="nucleotide sequence ID" value="XM_009175913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFT0"/>
    <dbReference type="GeneID" id="20329111"/>
    <dbReference type="KEGG" id="ovi:T265_14945"/>
    <dbReference type="CTD" id="20329111"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6866" checksum="8F4DC4025697D7B9" modified="2014-10-01" version="1" fragment="single">MLQETPNSHSAISSQQSCYTIKEPPSPFLRPDLAVVSGCPAGSARNHDRIQKTPPMIELVVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFT5</accession>
    <name>A0A074ZFT5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596919">
        <property type="protein sequence ID" value="KER22100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174146.1">
        <property type="nucleotide sequence ID" value="XM_009175882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFT5"/>
    <dbReference type="STRING" id="6198.A0A074ZFT5"/>
    <dbReference type="GeneID" id="20323887"/>
    <dbReference type="KEGG" id="ovi:T265_09719"/>
    <dbReference type="CTD" id="20323887"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000289">
        <property type="entry name" value="RNA polymerase-associated protein CTR9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000322">
        <property type="entry name" value="RNA polymerase-associated protein CTR9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1256" mass="143969" checksum="10836F85A5B2E23C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG21</accession>
    <name>A0A074ZG21_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170035.1">
        <property type="nucleotide sequence ID" value="XM_009171771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG21"/>
    <dbReference type="GeneID" id="20320676"/>
    <dbReference type="KEGG" id="ovi:T265_06497"/>
    <dbReference type="CTD" id="20320676"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF241">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="621" mass="70305" checksum="B376B3B91D8AEDAB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGB0</accession>
    <name>A0A074ZGB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_06514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170052.1">
        <property type="nucleotide sequence ID" value="XM_009171788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGB0"/>
    <dbReference type="STRING" id="6198.A0A074ZGB0"/>
    <dbReference type="GeneID" id="20320693"/>
    <dbReference type="KEGG" id="ovi:T265_06514"/>
    <dbReference type="CTD" id="20320693"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="3">
        <location>
            <begin position="153"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER26238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="645" mass="71447" checksum="A21A0B5ED1D69F3B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGK8</accession>
    <name>A0A074ZGK8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_09503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596901">
        <property type="protein sequence ID" value="KER22385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173855.1">
        <property type="nucleotide sequence ID" value="XM_009175591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGK8"/>
    <dbReference type="STRING" id="6198.A0A074ZGK8"/>
    <dbReference type="GeneID" id="20323672"/>
    <dbReference type="KEGG" id="ovi:T265_09503"/>
    <dbReference type="CTD" id="20323672"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="119"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER22385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="398" mass="43980" checksum="674B42AB00242C80" modified="2014-10-01" version="1">MSPPASNAQLPSPSRRIIGERNRGSYKHHTISTRFLQLIDPGTGGTKMKAKKSNEKDESDKEDEEKEKFKSSLKSAIIIQRPNISWDDVVGLSAAKEALKEAVILPIKFPHLFTGSRTPWRGILLYGPPGTGKSFLAKAVATEANNSTFLSVSSSDLVSKWLGESEKLVKTLFAMAREQKPSIVFIDEIDSICGSRNESESESARRIKTEFLVQMQGVGSDNDQVLVLAATNIPWTLDPAIRRRFEKRIYIPLPEAPERANMFKVNLGTTPHTLTQKDFISLGEQSEGYSGADIGIVVREALMMPVRKVQTATHFKRVSGTSPTDPTKTVNDLLTPCSPGDPGAIEMSWSDVPSDKLKEPPVSMIDMLQALQRNKHTVAQADLDRLEQFTREFGQEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH98</accession>
    <name>A0A074ZH98_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JNK1/MAPK8-associated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171181.1">
        <property type="nucleotide sequence ID" value="XM_009172917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH98"/>
    <dbReference type="GeneID" id="20321586"/>
    <dbReference type="KEGG" id="ovi:T265_07407"/>
    <dbReference type="CTD" id="20321586"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44990" checksum="A0E7764A6A1374B6" modified="2014-10-01" version="1">MNWTFMSSFNQLQLTNSWRKCAGTYCGHIENGTECGSCPWGTRVDVNDNRDSLCSVCTITPSLHGWMYLGFTVMMPMSFLFNFPSSPLQSPVTHSTCPNNPESSSGNRNMSTAIVHPPLLLQDQSSCGNPVRTCKYLSWGLVYFALHCLSAFVSILLFPPLGSLNLYSCVPQKLEDFYAPFLIVYGCPSEVVFPYLSLPLVYFAFSIFGCVLFYVAILLTPSGSVDLSKWLRVTHLSLYAYPVLGLVVFIFGGVLYYSYPYVILILAVIHSVYRFPAIFDYCAPTTNGSVLPVCHPLVVIRSLFCVPEPALALTLLVSLFCFGYSLISLDISTVWVLVFTFVPFLFYLLTLPFTHPFATSDGEERLQLALMRHNGTDSFVVSVHHRKQDISQERAIQPDSTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHM0</accession>
    <name>A0A074ZHM0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171068.1">
        <property type="nucleotide sequence ID" value="XM_009172804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHM0"/>
    <dbReference type="STRING" id="6198.A0A074ZHM0"/>
    <dbReference type="GeneID" id="20321496"/>
    <dbReference type="KEGG" id="ovi:T265_07317"/>
    <dbReference type="CTD" id="20321496"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59232" checksum="80223F2EA28B4CA5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHR1</accession>
    <name>A0A074ZHR1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170950.1">
        <property type="nucleotide sequence ID" value="XM_009172686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHR1"/>
    <dbReference type="SMR" id="A0A074ZHR1"/>
    <dbReference type="STRING" id="6198.A0A074ZHR1"/>
    <dbReference type="GeneID" id="20321400"/>
    <dbReference type="KEGG" id="ovi:T265_07221"/>
    <dbReference type="CTD" id="20321400"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="133"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="302"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="534"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="651"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="764" mass="83278" checksum="232BF33CE0D95BF6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI10</accession>
    <name>A0A074ZI10_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170811.1">
        <property type="nucleotide sequence ID" value="XM_009172547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI10"/>
    <dbReference type="GeneID" id="20321283"/>
    <dbReference type="KEGG" id="ovi:T265_07104"/>
    <dbReference type="CTD" id="20321283"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7063" checksum="B4D5E03E914C575A" modified="2014-10-01" version="1">MQSKRQCGTHRSLVEAKESFRRNTLLIMLLKALRQPTTNFIFLGSHQIGAITEFSSTLCALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIW0</accession>
    <name>A0A074ZIW0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596857">
        <property type="protein sequence ID" value="KER23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172989.1">
        <property type="nucleotide sequence ID" value="XM_009174725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIW0"/>
    <dbReference type="STRING" id="6198.A0A074ZIW0"/>
    <dbReference type="GeneID" id="20328844"/>
    <dbReference type="KEGG" id="ovi:T265_14678"/>
    <dbReference type="CTD" id="20328844"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
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        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="564"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="703"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="838"/>
            <end position="906"/>
        </location>
    </feature>
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            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
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            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
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            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
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            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125696" checksum="206FD70C70A8D4DA" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJC0</accession>
    <name>A0A074ZJC0_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">T265_08674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER23455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009174545.1"/>
    </dbReference>
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    <dbReference type="STRING" id="6198.A0A074ZJC0"/>
    <dbReference type="GeneID" id="20322853"/>
    <dbReference type="KEGG" id="ovi:T265_08674"/>
    <dbReference type="CTD" id="20322853"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="181"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
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            <end position="82"/>
        </location>
    </feature>
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            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER23455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="29456" checksum="652A7F0C42C6A743" modified="2014-10-01" version="1">MLYGGPLGTYLSGLSTSSGTSSHGTSLSPSNTYNSSSTPTTYLGSGIRRSNSRYRSSGVSPGSTLSQSPSSSSATTGFTSLSNYYTPQLRRKYGAPETDPPKSSGRYSSRTQPRTSTSPATSSTTSPTSTSTGLFHYSRWSPSKTSSPGSYVGPSIGTSASWNADLNTVSSGGGGSSATVDYKRLYEAEKLATDELRNEVMAAQKETRELQERIETAKQSRSMSGAHQRKIERRISECEEELKTLEKLRAESEKLRAEHRALVRVVARLNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJJ0</accession>
    <name>A0A074ZJJ0_OPIVI</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Spiralia</taxon>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009170483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJJ0"/>
    <dbReference type="STRING" id="6198.A0A074ZJJ0"/>
    <dbReference type="GeneID" id="20319654"/>
    <dbReference type="KEGG" id="ovi:T265_05472"/>
    <dbReference type="CTD" id="20319654"/>
    <dbReference type="OrthoDB" id="370281at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF16">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="528" mass="58634" checksum="F6919BFDB0D7792B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKM5</accession>
    <name>A0A074ZKM5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172359.1">
        <property type="nucleotide sequence ID" value="XM_009174095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKM5"/>
    <dbReference type="GeneID" id="20322508"/>
    <dbReference type="KEGG" id="ovi:T265_08329"/>
    <dbReference type="CTD" id="20322508"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="9877" checksum="B089D9E113CC55B8" modified="2014-10-01" version="1">MVSNVYVQMSAGVQTISEGEGGIPARRQYIRWVPVCGSQKLDRPGATIGFTRVLVAIEDPENHLVNVGKEDGFRQTSQLGTPDAEDKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKR3</accession>
    <name>A0A074ZKR3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596829">
        <property type="protein sequence ID" value="KER23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172328.1">
        <property type="nucleotide sequence ID" value="XM_009174064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKR3"/>
    <dbReference type="STRING" id="6198.A0A074ZKR3"/>
    <dbReference type="GeneID" id="20322487"/>
    <dbReference type="KEGG" id="ovi:T265_08308"/>
    <dbReference type="CTD" id="20322487"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="590" mass="64547" checksum="D34A4C79B69EFABB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMF3</accession>
    <name>A0A074ZMF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167972.1">
        <property type="nucleotide sequence ID" value="XM_009169708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMF3"/>
    <dbReference type="GeneID" id="20319036"/>
    <dbReference type="KEGG" id="ovi:T265_04854"/>
    <dbReference type="CTD" id="20319036"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15814" checksum="D3713D6A3BE6AFEE" modified="2014-10-01" version="1">MTAVTGLKKTRTSQTSLTKCLLPTDVLESSVNILWTRRLNVSHQATSCFLCLETSQTRDSAVFQVSLELWNRQKGIVKDKCAAPNLNELDDLKGTEHGPSTDLDETWVGNEEQVTSNLEAATDVQRLDSSSIDTKSFLQRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN43</accession>
    <name>A0A074ZN43_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167749.1">
        <property type="nucleotide sequence ID" value="XM_009169485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN43"/>
    <dbReference type="STRING" id="6198.A0A074ZN43"/>
    <dbReference type="GeneID" id="20327733"/>
    <dbReference type="KEGG" id="ovi:T265_13566"/>
    <dbReference type="CTD" id="20327733"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="546" mass="58443" checksum="C6F60C5AFF787D9C" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPG5</accession>
    <name>A0A074ZPG5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171058.1">
        <property type="nucleotide sequence ID" value="XM_009172794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20321486"/>
    <dbReference type="KEGG" id="ovi:T265_07307"/>
    <dbReference type="CTD" id="20321486"/>
    <dbReference type="OrthoDB" id="10324511at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="4072" mass="452790" checksum="3FF36FDEE458B6C8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPS4</accession>
    <name>A0A074ZPS4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166860.1">
        <property type="nucleotide sequence ID" value="XM_009168596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPS4"/>
    <dbReference type="GeneID" id="20318175"/>
    <dbReference type="KEGG" id="ovi:T265_03989"/>
    <dbReference type="CTD" id="20318175"/>
    <dbReference type="OrthoDB" id="6252874at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13664" checksum="FEB519657FD56E04" modified="2014-10-01" version="1">MHSSICNPSFNGPLTVQYLRANLSAPISNAQLPTPPPRIIGERKCCGYNHCTTKVVDKLVHLGSCISPGDLTKDDISMRIGKARSAFLNLWRRHDMSLFVKGAICNATARSVLRYGSEFCALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ18</accession>
    <name>A0A074ZQ18_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168341.1">
        <property type="nucleotide sequence ID" value="XM_009170077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ18"/>
    <dbReference type="GeneID" id="20327856"/>
    <dbReference type="KEGG" id="ovi:T265_13689"/>
    <dbReference type="CTD" id="20327856"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="10905" checksum="EE2FEE66E46CC36A" modified="2014-10-01" version="1">MNTQTPGGKSLLEYIPSIAETPGCLNGAQTLLKILRQLTTGFTLLGAHQVQSLSFCKPYVSFEVKLHLKDSVMAEHIPDMGHKIDLENAKVLRRGLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ39</accession>
    <name>A0A074ZQ39_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_07131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596777">
        <property type="protein sequence ID" value="KER25450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170838.1">
        <property type="nucleotide sequence ID" value="XM_009172574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ39"/>
    <dbReference type="STRING" id="6198.A0A074ZQ39"/>
    <dbReference type="GeneID" id="20321310"/>
    <dbReference type="KEGG" id="ovi:T265_07131"/>
    <dbReference type="CTD" id="20321310"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER25450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="688" mass="78342" checksum="E658D3A9A559A5CC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ69</accession>
    <name>A0A074ZQ69_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="1420" mass="154242" checksum="0BC9761D2110DB65" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="181" mass="20249" checksum="5C98D20A009C1016" modified="2014-10-01" version="1">MSDGKIDDALLKQMFLKGLPAHVSDTAPLAGLVNIADKILEIQPNSSNISTVEFTKLMSAIHDRLDTLATQIADIRLSRPHPFRRAHFLSRSRSPSHSNSRSHVYCWYHSTIGSRAQNCSQLCSFQRRYPSPYLLSEKCTGRTIETSKFQGPAHTTRRLTVVDKTSGLHFLTPELTSVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A074ZQJ2_OPIVI</name>
    <protein>
        <submittedName>
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        </submittedName>
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    </gene>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
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                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Gao S."/>
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                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="97"/>
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        </location>
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        </location>
    </feature>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="210" mass="24104" checksum="D88467D2BCFE3BA8" modified="2014-10-01" version="1" fragment="single">WVFLRQHEDYQYQPNSPLLEAAYAYFTSEDTTFLETPEGAVYAPAFRSVRWEYIVNVYKTTERMLRDRIVPESWLSQVFSRQWLRLLRMHDQQTSQSRLGSYTRSHSSTSSTSTVGGTHSSPVRIRTTLTARESSPVTDMMGGEDSPNPPSSPDDLSDDVFWLTSERCGRRIDNGEMTYSWRWTGFHFGLDVVVKYKRSLAIPGVLSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQR7</accession>
    <name>A0A074ZQR7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03665</name>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166471.1">
        <property type="nucleotide sequence ID" value="XM_009168207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQR7"/>
    <dbReference type="GeneID" id="20317852"/>
    <dbReference type="KEGG" id="ovi:T265_03665"/>
    <dbReference type="CTD" id="20317852"/>
    <dbReference type="OrthoDB" id="6247591at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="796" mass="92049" checksum="BEAF778367C7603F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRF0</accession>
    <name>A0A074ZRF0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167874.1">
        <property type="nucleotide sequence ID" value="XM_009169610.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZRF0"/>
    <dbReference type="GeneID" id="20318967"/>
    <dbReference type="KEGG" id="ovi:T265_04785"/>
    <dbReference type="CTD" id="20318967"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="93"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="459" mass="51182" checksum="DF0297919F6AD382" modified="2014-10-01" version="1">MSLAIDVARLGVPIQEDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKKSPRGSRSTGIRSTWPNQRNLCSVISSSIGGELFLPNTIRRTSELLIRLVVLYFGIGGLAIIKEQDEPRVKDYIEWIYSHHISSHDTRSCHGGFRSVLYTSQMPSFAKNDLGSSSYDCSHVTMVYAALCTLLILGDDLSRVDRHSVLSGVAALQCEDIPGLFRAALISPERDMRFVFSAVASCYMLNGLDYLDRETIVSFIGDSMTYEGGFGNLPGLEAHAGATYCALASLSLLGRLHSFLPKESRVYDRLVKWLVKLQAEGFHGRPQKDDDTCYTFWVCASLKLLNAQDLIDQGALLKFIARCWDQVIGGIRKYPSPSCVADPLHSFLALSGLSCLKAQTVAAVDSNHLESSDPDKSWSEHSMEPLDQFRWLHMNKLEPILPELNIPEVAHRHLRRIHQSWEASRATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRP0</accession>
    <name>A0A074ZRP0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">inositol-1,4-bisphosphate 1-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="7"/>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167786.1">
        <property type="nucleotide sequence ID" value="XM_009169522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRP0"/>
    <dbReference type="STRING" id="6198.A0A074ZRP0"/>
    <dbReference type="GeneID" id="20318900"/>
    <dbReference type="KEGG" id="ovi:T265_04718"/>
    <dbReference type="CTD" id="20318900"/>
    <dbReference type="OrthoDB" id="9977309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.460.10">
        <property type="entry name" value="Inositol Polyphosphate 1-phosphatase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044897">
        <property type="entry name" value="INPP1_dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF3">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 1-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0452">Lithium</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="478" mass="52705" checksum="1DE93357F19D1ABA" modified="2014-10-01" version="1">MICDNLTPVTILLETLVLCSEKAADIARLIRTQYALFPTLIQHKTHKESGTNFAADVMTLADVLIQQSIRHDIGKEFPGFGDSVYGEENSVFRAAQSGENIQLTIPQTLDELQTQVLVDQPSLAGALAELILCPLSHFRLRSAVREHLVSISQLDVSARLDLTQFAVWVDPIDGTAEYVKGNACDVSSEETRAPSLDIISPHVFRYRISGTLGNVTVLIGLFNRTSRLPVFGVINQPFFPRVAANLGNSQPSGRLFWGSTLGGSYLSSNCLPSSAPSITKCFPDWSFQELFSLSDPMNNVGRLRVACSSSDLDSLERILKDYTPVDDDLPPELVFVSCAGAGFKLLCLILCQLDIYLLLKPNTYFWDTCAPHAILHARGGGLVRLKPALSYVREQSMTGVCDLDPSTLREFEVHYSVKPSDYTIFFYSGGLLTSLSSRQDLSCCCNLDGLLAYRDGRIACQFLHRLARSVNTVDELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSN1</accession>
    <name>A0A074ZSN1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">CDP-diglyceride pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">CDP-diglyceride synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_16172</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="KL604755">
        <property type="protein sequence ID" value="KER18274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177979.1">
        <property type="nucleotide sequence ID" value="XM_009179715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSN1"/>
    <dbReference type="STRING" id="6198.A0A074ZSN1"/>
    <dbReference type="GeneID" id="20330337"/>
    <dbReference type="KEGG" id="ovi:T265_16172"/>
    <dbReference type="CTD" id="20330337"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER18274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10703" checksum="3D3E505726424802" modified="2014-10-01" version="1" fragment="single">MPVALVICNDIMAYVFGFFFGKTPLIKLSPKKTWEGFIGGGLATILFGFFFSLILLRYDYFVCPLEWDDTIGALTTSCTRNPVFIPRTYNVSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSN3</accession>
    <name>A0A074ZSN3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_03386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166119.1">
        <property type="nucleotide sequence ID" value="XM_009167855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSN3"/>
    <dbReference type="STRING" id="6198.A0A074ZSN3"/>
    <dbReference type="GeneID" id="20317573"/>
    <dbReference type="KEGG" id="ovi:T265_03386"/>
    <dbReference type="CTD" id="20317573"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
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                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <lineage>
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            <taxon>Trematoda</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="20008" checksum="FAECE8F9C9290689" modified="2014-10-01" version="1" fragment="single">PEGISLWEQIVSKAQLKRESSSRPESPNPARNRFVQNNSCSQVDHLTSDVLQKPTHEPHEQKNNPTEYSQQYIFLYFCRDWLPCCKRRKKTTVLKQPDSFSFALHFHLERKQFRFNGHDFLTLYLYQRRRTKSNEIPVKQLSDIPWVAKEWAVRQRPPLPLNLQWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW85</accession>
    <name>A0A074ZW85_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="2 5">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="2 5"/>
    <dbReference type="EMBL" id="KL597201">
        <property type="protein sequence ID" value="KER19464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176785.1">
        <property type="nucleotide sequence ID" value="XM_009178521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW85"/>
    <dbReference type="STRING" id="6198.A0A074ZW85"/>
    <dbReference type="GeneID" id="20329696"/>
    <dbReference type="KEGG" id="ovi:T265_15531"/>
    <dbReference type="CTD" id="20329696"/>
    <dbReference type="OrthoDB" id="545675at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="336" mass="39438" checksum="447F1B074F351EF5" modified="2014-10-01" version="1" fragment="single">LRRWRCTAFTLLFVVFLLLLGFRIIDEPVFEWKPLKMTDNTEQRHSPIIFVGGVSRSGTTLMRVLLDVHPWIRCGPEGMVIKPVLDFRHSMPRFHMNWSRQAGIYPTLLDSAISKYIRYIVEEMGPPANILCYKRPEVLLYTEYLATLFPDSKFIIMLRDGRAVAVSNKRFKRNTTEKMHNVLNRWMLENINLTRACQNVGPKRCLIVRYELLILNPERELKLVTRFLDIPWDPVMLHHEELLRNRPSINPYEPSTSQVKEKINNEALARWFTDTDNDTKIFVKEAPQKCFLLKAFGYLNIGVPPDYSKLPRDLPDVSRFKPPKESKVSKRLDKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX02</accession>
    <name>A0A074ZX02_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164584.1">
        <property type="nucleotide sequence ID" value="XM_009166320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX02"/>
    <dbReference type="GeneID" id="20316334"/>
    <dbReference type="KEGG" id="ovi:T265_02146"/>
    <dbReference type="CTD" id="20316334"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13348" checksum="E635FB0A0C377DA6" modified="2014-10-01" version="1">MTMQHIVQENFLMIWAYISVKYPSNCGYGKAADFDDNHTVGALHGTTWPVDKAPVYNATENDVEANSSQGNLHALGRFHVETKALDLSSHPLGVYLWCVFFSILGFHLHSAVVVSNRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXF0</accession>
    <name>A0A074ZXF0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596642">
        <property type="protein sequence ID" value="KER31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164561.1">
        <property type="nucleotide sequence ID" value="XM_009166297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXF0"/>
    <dbReference type="GeneID" id="20327097"/>
    <dbReference type="KEGG" id="ovi:T265_12929"/>
    <dbReference type="CTD" id="20327097"/>
    <dbReference type="OrthoDB" id="6239655at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="516" mass="57523" checksum="BBFFF16F3E89AA91" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXH7</accession>
    <name>A0A074ZXH7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannose-1-phosphate guanyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164432.1">
        <property type="nucleotide sequence ID" value="XM_009166168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXH7"/>
    <dbReference type="STRING" id="6198.A0A074ZXH7"/>
    <dbReference type="GeneID" id="20316208"/>
    <dbReference type="KEGG" id="ovi:T265_02020"/>
    <dbReference type="CTD" id="20316208"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="1">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="330" mass="36937" checksum="10D23CF14E36DC00" modified="2014-10-01" version="1">MDIGQPADYLEGVRLYLAHLSEQKSLALKTLPDLLGNVMVRDLFICQICKWDPNLEDLCSDLVCRTAIETSKIRRTLHNLECTFCDCNWRVHSGPASWPSTHLNFTTHPLFQDPTAKIGKDCRIGPNVTIGAHVIIEDGVRISNSAIFSRSVIRSHAWLNNCIVGWRSTVGRWVRSGWRRTPNLDCQLRAFVRPLTIDQPIMIDFQCHADSSAGRGGTPTVTLRYTDPTAKIGKDCRIGPNVTIGAHVIIEDGVRISNSAIFSRSVIRSHAWLNNCIVGWRSTVGRWVRIENMTVLGENVRVKDEIFLNGALVLPHNAISQSVTEPHIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY54</accession>
    <name>A0A074ZY54_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165309.1">
        <property type="nucleotide sequence ID" value="XM_009167045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY54"/>
    <dbReference type="GeneID" id="20316918"/>
    <dbReference type="KEGG" id="ovi:T265_02730"/>
    <dbReference type="CTD" id="20316918"/>
    <dbReference type="OrthoDB" id="10512014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8173" checksum="4DEED2DF019C0905" modified="2014-10-01" version="1">MPESPWGGEKRRVTDGRLGSADILTYQRMSSFGPYPARDTVNLSRGQPSLITKHHIIWTDLSRAGYGPNEDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ75</accession>
    <name>A0A074ZZ75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597051">
        <property type="protein sequence ID" value="KER20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175762.1">
        <property type="nucleotide sequence ID" value="XM_009177498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ75"/>
    <dbReference type="STRING" id="6198.A0A074ZZ75"/>
    <dbReference type="GeneID" id="20329473"/>
    <dbReference type="KEGG" id="ovi:T265_15308"/>
    <dbReference type="CTD" id="20329473"/>
    <dbReference type="OrthoDB" id="18134at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038060">
        <property type="entry name" value="C12orf66-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018544">
        <property type="entry name" value="KICS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN C12ORF66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31581:SF1">
        <property type="entry name" value="KICSTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09404">
        <property type="entry name" value="C12orf66_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160651">
        <property type="entry name" value="FLJ32549 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158548">
        <property type="entry name" value="FLJ32549 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="695" mass="77967" checksum="E6C1E637728378D7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZQ3</accession>
    <name>A0A074ZZQ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597036">
        <property type="protein sequence ID" value="KER20639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175617.1">
        <property type="nucleotide sequence ID" value="XM_009177353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZQ3"/>
    <dbReference type="GeneID" id="20325031"/>
    <dbReference type="KEGG" id="ovi:T265_10863"/>
    <dbReference type="CTD" id="20325031"/>
    <dbReference type="OrthoDB" id="6279736at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12846" checksum="6974C419928EC32D" modified="2014-10-01" version="1">MIMTMFDCCGYNNGTDFLATGAQFTHRDSYGGHNFPLIPYPAPCCKKGHIGEGALECPQMFTELNSNYLRGCNKGLHHSLKKPVMLIALGSLVIPIVAVMCICLSILVKWIVPKLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZW5</accession>
    <name>A0A074ZZW5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ligand-gated ion channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_04392</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Postsynaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167395.1">
        <property type="nucleotide sequence ID" value="XM_009169131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZW5"/>
    <dbReference type="STRING" id="6198.A0A074ZZW5"/>
    <dbReference type="GeneID" id="20318574"/>
    <dbReference type="KEGG" id="ovi:T265_04392"/>
    <dbReference type="CTD" id="20318574"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Periplasmic binding protein-like I"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="448"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="458"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="94338" checksum="F3B5F1F81F91CD4B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZZ6</accession>
    <name>A0A074ZZZ6_OPIVI</name>
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            <fullName evidence="9">Tetraspanning orphan receptor</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">T265_02224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GeneID" id="20316412"/>
    <dbReference type="KEGG" id="ovi:T265_02224"/>
    <dbReference type="CTD" id="20316412"/>
    <dbReference type="OrthoDB" id="10002163at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62251" checksum="2483CE902AC46D20" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009169063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A061"/>
    <dbReference type="GeneID" id="20327649"/>
    <dbReference type="KEGG" id="ovi:T265_13482"/>
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    <dbReference type="OrthoDB" id="6237947at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="23722" checksum="D3A3326DE29F2808" modified="2014-10-01" version="1" fragment="single">KSAKNETDFERTGPLDDKNKTDPGNLGETSFLCVDPSVREGCNIFRISRELNILLCLSTLFSDILFLVCARLFPVLSGCSLDSTVFRALLPMDRDILRRLVRVGKQKIAKLDRQSPGKLLDRHLLCRALSRWRALRDNLGRHSLWVTGCSAGAFSWDEDCSFESVSSLSEFPPPSDYPSSPVTEPTTEADIVLSSSACSQFTNPDEKLYCPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A210</accession>
    <name>A0A075A210_OPIVI</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="ovi:T265_00424"/>
    <dbReference type="CTD" id="20314612"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13021" checksum="5C080B0A2517924A" modified="2014-10-01" version="1">MAGYARDTEFKVDMKNLNIETRTKIQTTVTGGGAVEIAKRPRTIAPRYSAEVNSSDEEVSLMNSCPVVSNSLKQFDWKGHQPEPVNSSIDAKDQNVMQEATHWHRKISNQEKQACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Y8</accession>
    <name>A0A075A2Y8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162647.1">
        <property type="nucleotide sequence ID" value="XM_009164383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Y8"/>
    <dbReference type="GeneID" id="20314767"/>
    <dbReference type="KEGG" id="ovi:T265_00579"/>
    <dbReference type="CTD" id="20314767"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="555" mass="62993" checksum="74693F5CCCA9A9A6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A410</accession>
    <name>A0A075A410_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163304.1">
        <property type="nucleotide sequence ID" value="XM_009165040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A410"/>
    <dbReference type="STRING" id="6198.A0A075A410"/>
    <dbReference type="GeneID" id="20315285"/>
    <dbReference type="KEGG" id="ovi:T265_01097"/>
    <dbReference type="CTD" id="20315285"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="321" mass="35576" checksum="2DCCFF822C0EDFDC" modified="2014-10-01" version="1">MGWPGAAHSVGKDITNERFSCIPVILPEETHGASRMSHELVYGHHALGEASRRDHLQPFDILISVGRIAALVDDEDDDDDDNDDDDDDDDDDDDDDDDGDDDDDDGDDDDDGDRDDDDDEEEEEENDEDNDEDDNDGDDDDCGDDDDDGDNVADFARRFIIPIAEMRDKCTVVTDCHGFTGSAFEAFELQSHEFLVITGFESEVCKAYARKLGLKLPVSINSEIGQNNFIANFLQGRLGSSSLDRSRSTSKQALLAERTATPYPISSSEGRSMFTFHSPVCIDQQKPQAVHYVKEYTPGPGTYELYPIPMKPVRSGSLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5B6</accession>
    <name>A0A075A5B6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THO complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596889">
        <property type="protein sequence ID" value="KER22604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173642.1">
        <property type="nucleotide sequence ID" value="XM_009175378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5B6"/>
    <dbReference type="STRING" id="6198.A0A075A5B6"/>
    <dbReference type="GeneID" id="20323511"/>
    <dbReference type="KEGG" id="ovi:T265_09338"/>
    <dbReference type="CTD" id="20323511"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83555" checksum="3D4E2776828589D5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A990</accession>
    <name>A0A075A990_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acyl-L-amino-acid amidohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KL596823">
        <property type="protein sequence ID" value="KER24084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172178.1">
        <property type="nucleotide sequence ID" value="XM_009173914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A990"/>
    <dbReference type="STRING" id="6198.A0A075A990"/>
    <dbReference type="GeneID" id="20328661"/>
    <dbReference type="KEGG" id="ovi:T265_14495"/>
    <dbReference type="CTD" id="20328661"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27945" checksum="086C3D49C73A9692" modified="2014-10-01" version="1" fragment="single">MDMTCCIPGCPKGNKMNEEELDALAVDNFRAYLRFPTVHPNPDYSAAVHWLRQQGESLGLTCFITELIPSNPILIMRWKGREPDLPAILLNSHMDVVPVKEENWTYPPFSGVLSEDGKIYGRGSQDMKCVGIHQLEAVRRLKNRGIAELRRTVFLSFVPDEELGGVRGMQPFIEGKHPLHPESPNEVQFTKLNIGLCLDEGIASPTDDYVAFYAERTQCWFNIRFKGVAGHGLTLLDGTAGEKLQLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAN1</accession>
    <name>A0A075AAN1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163365.1">
        <property type="nucleotide sequence ID" value="XM_009165101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAN1"/>
    <dbReference type="GeneID" id="20315328"/>
    <dbReference type="KEGG" id="ovi:T265_01140"/>
    <dbReference type="CTD" id="20315328"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705459" evidence="1">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7186" checksum="720B0236716F1285" modified="2014-10-01" version="1">MVFAIHWLLNYVSLQAKICTLPRPYGDGPAAAPFRCQAAMPPKGCMRAMILPVCPSLDRKGRVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABH5</accession>
    <name>A0A075ABH5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_07456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596790">
        <property type="protein sequence ID" value="KER25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171249.1">
        <property type="nucleotide sequence ID" value="XM_009172985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABH5"/>
    <dbReference type="STRING" id="6198.A0A075ABH5"/>
    <dbReference type="GeneID" id="20321635"/>
    <dbReference type="KEGG" id="ovi:T265_07456"/>
    <dbReference type="CTD" id="20321635"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704578" description="PLD phosphodiesterase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER25004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="458" mass="51901" checksum="E6353C748EF9025C" modified="2014-10-01" version="1">MIKFHSRLLFMVISLIGLSRARNVVFQKPTLQTHNLPLTIQHGRILTGSIGCKILLVESIPQNLTYSPDSPKHASTLFAWQVLLDQVTQNLSLASFYWSLIAEPQFNRSAIHEGRAIYETLLEKANQVKLTVAQSGAKKENNELDQLSAAGAQVYWVDVARLLGRGVLHTKLWAIDRKHGYIGSANMDWRSLTEVKELGGLLLNCPELVHELEKIHGAYCLATERIPAQWPKELETVYNHTNPLVTKINGIRSRVYVSGSPREFNPPGRTYDLDAILLTIAQAKKYIYISVMDYSPEVVSYDIETPKKYWPAIDTALREAAIDRGVEVRLLISRWPYTVPTMFKYLSSLRALNGIGGSQLRVRYFVVPSFTDEQIMIPHARVNHNKYMVTEKTAYIGTSNWSGDYFLYTGGAGLVVEEDTVDNSFTDSICDGNKPKTLQAQLTDIFYRDWNSEYSYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD42</accession>
    <name>A0A075AD42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_00199</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162171.1">
        <property type="nucleotide sequence ID" value="XM_009163907.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AD42"/>
    <dbReference type="GeneID" id="20314387"/>
    <dbReference type="KEGG" id="ovi:T265_00199"/>
    <dbReference type="CTD" id="20314387"/>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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                <person name="Nagarajan N."/>
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                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="function">
        <text evidence="1">GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166494.1">
        <property type="nucleotide sequence ID" value="XM_009168230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHF2"/>
    <dbReference type="STRING" id="6198.A0A075AHF2"/>
    <dbReference type="GeneID" id="20317875"/>
    <dbReference type="KEGG" id="ovi:T265_03688"/>
    <dbReference type="CTD" id="20317875"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27581" checksum="81EC6C2CA9FE9955" modified="2014-10-01" version="1">MTAKLECSAASLWCGLTGTITPEQEDGRSSRSDVTTNKLYYFTFRARAEVIRMVLHAAGVPFDDERISADDWPKRKSEIPGGRMPVLQVFEPGRPDKPKNYVESMAIARMLAKRFNLMDDTEEGYYNIERMIGECEDVLKELRNAFLSPADKKEQLVKEAMETSIPKLLNLISQSLSESAGRFVAGCKVTLGDLCLLACLDHVDKADPELVKNKYPKLLEWREAVLKEKPKLADYIKSRPDTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHY9</accession>
    <name>A0A075AHY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA helicase MCM8</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_13135</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165591.1">
        <property type="nucleotide sequence ID" value="XM_009167327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHY9"/>
    <dbReference type="STRING" id="6198.A0A075AHY9"/>
    <dbReference type="GeneID" id="20327303"/>
    <dbReference type="KEGG" id="ovi:T265_13135"/>
    <dbReference type="CTD" id="20327303"/>
    <dbReference type="OrthoDB" id="422555at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097362">
        <property type="term" value="C:MCM8-MCM9 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000007">
        <property type="entry name" value="DNA helicase MCM8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="492"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111341" checksum="FC2C9DD31805394B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIG4</accession>
    <name>A0A075AIG4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596644">
        <property type="protein sequence ID" value="KER31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164712.1">
        <property type="nucleotide sequence ID" value="XM_009166448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIG4"/>
    <dbReference type="GeneID" id="20327127"/>
    <dbReference type="KEGG" id="ovi:T265_12959"/>
    <dbReference type="CTD" id="20327127"/>
    <dbReference type="OrthoDB" id="10299978at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="309" mass="35012" checksum="8D2E6B925D7137B4" modified="2014-10-01" version="1" fragment="single">MSCRHFPVWHGRTFEINRIDYELHKYFPSKLSGTKIQQQNIYNMVHSELSSRCMVLDQLERENSALLSRISRFEAFLDALNYDHIQGNQTTVNRPQLYFEPATKTASLCANAFPSNSTCNRNLQGVGTSNMCITEPIVPGRKIFPSKELVEIPLNKLDRQCGICSSRIHQHRSLNRPPESMLSNQDDLGESMHVGMDDFYLGSDSTVNIHIQLKQDHCGSSTQRSEVGVSFSNETPRRITTEQVGIILYRIIAQLKGIQKRTWKPHETIDKRQGKDSANSFGSWDTPTQTSTPKASKVGTAVDAQQMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AII0</accession>
    <name>A0A075AII0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 UFM1-protein ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164611.1">
        <property type="nucleotide sequence ID" value="XM_009166347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AII0"/>
    <dbReference type="STRING" id="6198.A0A075AII0"/>
    <dbReference type="GeneID" id="20316361"/>
    <dbReference type="KEGG" id="ovi:T265_02173"/>
    <dbReference type="CTD" id="20316361"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="604" mass="67436" checksum="5187DA44F95D295D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ51</accession>
    <name>A0A075AJ51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_12754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163541.1">
        <property type="nucleotide sequence ID" value="XM_009165277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ51"/>
    <dbReference type="STRING" id="6198.A0A075AJ51"/>
    <dbReference type="GeneID" id="20326922"/>
    <dbReference type="KEGG" id="ovi:T265_12754"/>
    <dbReference type="CTD" id="20326922"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27184" checksum="E67073B40A0D6E9F" modified="2014-10-01" version="1" fragment="single">MDNAPSKNWELTLYELHRKPQEPITDGTEIAVSPRSLKSELMCPICLDILKGTMTTKECLHRFCAECIVTALRSGNKECPTCRKKLVSKRSLRRDPNFDALIAKIYPSREEYEAHQDKILAKLNRHHLSAALTRSLEQQLALSSTRSRPCSNGRLHHNSNPIDGNADAAASEDDISTEYEAHQDKILAKLNRHHLSAALTRSLEQQLALSSTRSRPCSNGRLHHNSNPIDGNADAAASEDDIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG5</accession>
    <name>A0A075AJG5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162995.1">
        <property type="nucleotide sequence ID" value="XM_009164731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJG5"/>
    <dbReference type="STRING" id="6198.A0A075AJG5"/>
    <dbReference type="GeneID" id="20326817"/>
    <dbReference type="KEGG" id="ovi:T265_12649"/>
    <dbReference type="CTD" id="20326817"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="238" mass="26490" checksum="C0FA0827AB030F41" modified="2014-10-01" version="1" fragment="single">YPCSGVLPTVNSTFLGPILWEDTLPISDLDTINLEEFSPELLERSASVAGTVGNNEAFGKVLDLDPLTQPRVNLTWTGTPPNSTPTTNDVAAENGPLPTRKKSSVPVDQRNEKYWSRRMKNNASAKRSRDARRMLENQVHMKATALERENEQLRLQMTLLVEENKKLRDLLNQANIHLPPSSVIYPPVPASTVARENVSSYSPILPERPVFVPSVSLQDPTSCPSPSFCWNHVRSDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJK3</accession>
    <name>A0A075AJK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596624">
        <property type="protein sequence ID" value="KER33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162736.1">
        <property type="nucleotide sequence ID" value="XM_009164472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJK3"/>
    <dbReference type="GeneID" id="20314832"/>
    <dbReference type="KEGG" id="ovi:T265_00644"/>
    <dbReference type="CTD" id="20314832"/>
    <dbReference type="OrthoDB" id="6150535at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11292" checksum="7AD6310C93950786" modified="2014-10-01" version="1">MQTTSFSFSKRRIRRRFFLDELTKVTPVFGHARGRANTEHATYNLGEALEVVERFTYLGSFIFSDCSVTGECRRIRNEVIRRRVFGCATVTFIEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJY4</accession>
    <name>A0A075AJY4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferritin</fullName>
            <ecNumber evidence="10">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_12440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="10"/>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162120.1">
        <property type="nucleotide sequence ID" value="XM_009163856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJY4"/>
    <dbReference type="STRING" id="6198.A0A075AJY4"/>
    <dbReference type="GeneID" id="20326608"/>
    <dbReference type="KEGG" id="ovi:T265_12440"/>
    <dbReference type="CTD" id="20326608"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014034">
        <property type="entry name" value="Ferritin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00540">
        <property type="entry name" value="FERRITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00204">
        <property type="entry name" value="FERRITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="2 10" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="20217" checksum="8D199AEA9DAF3CC9" modified="2014-10-01" version="1">MEPLARQNFSQECEAAINKQINIELEASYAYFAFSAFYDQDTVALPKVAEFFRKMSHEEREHAEKFAHYQNQRGGRVVYQDIKKPSKVTFSSLQEVMETSLNMEKSVNESLLRMHHIAGEHRDPALQDFIETEFLQEQVKSIKEFADYVTQTKRNGPNLGEYLFERLSLKDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTU6</accession>
    <name>A0A074YTU6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRESS-DNA virus Rep endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_16225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606554">
        <property type="protein sequence ID" value="KER18201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178052.1">
        <property type="nucleotide sequence ID" value="XM_009179788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTU6"/>
    <dbReference type="GeneID" id="20330390"/>
    <dbReference type="KEGG" id="ovi:T265_16225"/>
    <dbReference type="CTD" id="20330390"/>
    <dbReference type="OrthoDB" id="1732219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049912">
        <property type="entry name" value="CRESS_DNA_REP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02407">
        <property type="entry name" value="Viral_Rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52020">
        <property type="entry name" value="CRESS_DNA_REP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRESS-DNA virus Rep endonuclease" evidence="11">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER18201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="21557" checksum="34FD8FC504524737" modified="2014-10-01" version="1" fragment="single">MGERLPRGRNFVVTINNPTETPDELVRLFLANNIQYAFQRERGREEGTEHYQMCLHFQDAKTCRQVITLLPGCHVEFARNPIAARRYRVKADTGIEGPWTNDEEKTEGAKKENTMHEIVEKYESGTRIHQLAEEYPNLFARNFNNICRTLDLVCHYTPRSTKTEILWFYGKTGTGKSSKALQMVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUC5</accession>
    <name>A0A074YUC5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603726">
        <property type="protein sequence ID" value="KER18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177940.1">
        <property type="nucleotide sequence ID" value="XM_009179676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUC5"/>
    <dbReference type="GeneID" id="20330308"/>
    <dbReference type="KEGG" id="ovi:T265_16143"/>
    <dbReference type="CTD" id="20330308"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7643" checksum="7BF1323C7A98EBC6" modified="2014-10-01" version="1" fragment="single">IRLLVSRWCYSSQPHSPEEVPSPRQIRLSVPQLLGDLTSAFKFLEPSQRSRKALSVGIPEPGLLDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YW50</accession>
    <name>A0A074YW50_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">T265_12104</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KL597524">
        <property type="protein sequence ID" value="KER18908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177345.1">
        <property type="nucleotide sequence ID" value="XM_009179081.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YW50"/>
    <dbReference type="GeneID" id="20326272"/>
    <dbReference type="KEGG" id="ovi:T265_12104"/>
    <dbReference type="CTD" id="20326272"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15557">
        <property type="entry name" value="PHD_CBP_p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15802">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003101">
        <property type="entry name" value="KIX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056484">
        <property type="entry name" value="PHD_P300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010303">
        <property type="entry name" value="RING_CBP-p300"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02172">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23570">
        <property type="entry name" value="PHD_P300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06001">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47040">
        <property type="entry name" value="Kix domain of CBP (creb binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50952">
        <property type="entry name" value="KIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 20" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="KIX" evidence="25">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="22">
        <location>
            <begin position="405"/>
            <end position="477"/>
        </location>
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        <location>
            <begin position="633"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="24">
        <location>
            <begin position="1023"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="23">
        <location>
            <begin position="1079"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="19">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TAZ-type" evidence="19">
        <location>
            <begin position="1079"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="312"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="866"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1196"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1361"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1444"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1714"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1753"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1782"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1893"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
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        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
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        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
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        <location>
            <begin position="1196"/>
            <end position="1215"/>
        </location>
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        <location>
            <begin position="1219"/>
            <end position="1238"/>
        </location>
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        <location>
            <begin position="1245"/>
            <end position="1261"/>
        </location>
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        <location>
            <begin position="1262"/>
            <end position="1285"/>
        </location>
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        <location>
            <begin position="1294"/>
            <end position="1307"/>
        </location>
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        <location>
            <begin position="1308"/>
            <end position="1317"/>
        </location>
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        <location>
            <begin position="1402"/>
            <end position="1413"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1451"/>
            <end position="1476"/>
        </location>
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            <end position="1524"/>
        </location>
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        <location>
            <begin position="1730"/>
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        </location>
    </feature>
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            <begin position="1757"/>
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        </location>
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        </location>
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        <location>
            <begin position="1920"/>
            <end position="1950"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER18908.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1950" mass="217493" checksum="8E898D32FE182824" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWC7</accession>
    <name>A0A074YWC7_OPIVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15715</name>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009179002.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="173" mass="19333" checksum="E9816CAFE540126B" modified="2014-10-01" version="1" fragment="single">MSAFPVCRVAAPNLLSKLQKTHLPTNIPPLIRSQAVGLLNTKKEKFNLQVVFPKDTTCNHVPGFIHEYLHVTYSKSGLLFKCKTETVSACIMRAVFFDVPSEAQKMGLQECSAWQKFILCTQYLLRAALANGLAKRRTGIYADNSTQKFTTMELLESSADKAAIVVLVYYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZ73</accession>
    <name>A0A074YZ73_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP30-binding protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">T265_11379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597111">
        <property type="protein sequence ID" value="KER19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009178018.1"/>
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    <dbReference type="STRING" id="6198.A0A074YZ73"/>
    <dbReference type="GeneID" id="20325547"/>
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    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47244" checksum="BB340944A2F3801A" modified="2014-10-01" version="1">MKLTKVKLSSAETSNPPGWDDYAESQNFPPIYTSEDEHEMTPRQPIQRKDLIPIDPDPLEVDMLQTISEAADIAAKKPKMSAAASLVSYALDEDEDDEDQSVLTGEEEENSSHFADFIKPLDKPDLVHYSVNAENDTSSSHLELEDRDIADTENQSTLLMGSTHQTIQQPIHVPSQEQLRMPQISDTQPKDPSPTSQPVFEPSYDRSKIKQLLEEVELPPEPSGHCPMKLQERVDREVHRMRLEIDYDPNRAIQDNKAFRNPRFVICVHFLIIFPLCSIYEKLIAFLNIDEKGTNFPPEVYNPYRWAPQSYYDELARVQNREIDRLVKLQKEQKKADQTSNDTGIKVGGGALSGGLTKTASQPVLNTSSGGSVATGYTEPKKRSKWDTGIPETSSLPMEEAPMKNNTATVPHAVDALAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZN2</accession>
    <name>A0A074YZN2_OPIVI</name>
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        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">T265_11179</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="KL597077">
        <property type="protein sequence ID" value="KER20226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176033.1">
        <property type="nucleotide sequence ID" value="XM_009177769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZN2"/>
    <dbReference type="STRING" id="6198.A0A074YZN2"/>
    <dbReference type="GeneID" id="20325347"/>
    <dbReference type="KEGG" id="ovi:T265_11179"/>
    <dbReference type="CTD" id="20325347"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="404"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="837"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KER20226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122485" checksum="675D66B5BE70D800" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z096</accession>
    <name>A0A074Z096_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597543">
        <property type="protein sequence ID" value="KER18897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177356.1">
        <property type="nucleotide sequence ID" value="XM_009179092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z096"/>
    <dbReference type="GeneID" id="20326276"/>
    <dbReference type="KEGG" id="ovi:T265_12108"/>
    <dbReference type="CTD" id="20326276"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="21707" checksum="2EE7329020558D00" modified="2014-10-01" version="1">MGLKKQAPRQEEYYADEVGLIEDLITQGAVPLSTCCSPVSVNLHTSDVIVKFGTKRTKHTNPSPLQCFIIDSIVSDDDHGKNYSDDDEGKICLSLSNWCQYFVSRLSLPASSSGLHLFSSAHSDGTVGRTRILRTAGELATDYTDMAPGAADYFVLPRYRACQITLAELCLKRTKPRNLTCHAARAAVSTPNVTSRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0H6</accession>
    <name>A0A074Z0H6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597410">
        <property type="protein sequence ID" value="KER18977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177275.1">
        <property type="nucleotide sequence ID" value="XM_009179011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0H6"/>
    <dbReference type="GeneID" id="20326238"/>
    <dbReference type="KEGG" id="ovi:T265_12070"/>
    <dbReference type="CTD" id="20326238"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8732" checksum="0E0988269ACB0958" modified="2014-10-01" version="1">MGSATVDTAHSLTYTQQQSKCRSWVRYNCCQSPDRLETVFASLPLRGLQFKHARFDVRYYAFRLGGKKLTLSQNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z131</accession>
    <name>A0A074Z131_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597305">
        <property type="protein sequence ID" value="KER19162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177090.1">
        <property type="nucleotide sequence ID" value="XM_009178826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z131"/>
    <dbReference type="GeneID" id="20329802"/>
    <dbReference type="KEGG" id="ovi:T265_15637"/>
    <dbReference type="CTD" id="20329802"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="80" mass="9349" checksum="0FD0A9317216F690" modified="2014-10-01" version="1" fragment="single">MACEENLVDLKHADDIDFVFEEVKKAQLNVLHLAASYFSRYEIPDIAIHVYLIKVLHDAPQNGRRRLWAIDGFPSLYLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z146</accession>
    <name>A0A074Z146_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597034">
        <property type="protein sequence ID" value="KER20658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175598.1">
        <property type="nucleotide sequence ID" value="XM_009177334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z146"/>
    <dbReference type="GeneID" id="20325017"/>
    <dbReference type="KEGG" id="ovi:T265_10849"/>
    <dbReference type="CTD" id="20325017"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="13793" checksum="DE73774479C79537" modified="2014-10-01" version="1">MYIQRTAGQSQFLTLGATMQGQTGALRPRAARPRIKSNRATRRSGGEMVPSLQQECEGSKVLPPGDQHVHIYGGSDAAFPREKTGQKRSALKTIQSDRPDRRDRRRIIQSGAAQKAPIVRSRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1A9</accession>
    <name>A0A074Z1A9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_10686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597016">
        <property type="protein sequence ID" value="KER20841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175405.1">
        <property type="nucleotide sequence ID" value="XM_009177141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1A9"/>
    <dbReference type="STRING" id="6198.A0A074Z1A9"/>
    <dbReference type="GeneID" id="20324854"/>
    <dbReference type="KEGG" id="ovi:T265_10686"/>
    <dbReference type="CTD" id="20324854"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER20841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="340" mass="38256" checksum="8A04454829447FF8" modified="2014-10-01" version="1">MAFDTSSISRGGLGLFGQLVIGPPGSGKTTYCAAMADFLTNLERKVHVVNLDPANDTLPYSCSVDLSDLIRLEEVMDYLSLGPNGGLIYCMEYLYTNRDWLADRLIKLKQKDPKCYLIFDCPGQVELYTHHPVTRQLIAYLTQKTHQNPGEKGESVTIVEGLGLQLTAVHLVDSHYCSDPGKFISCLLTSLSTMLQLSLPHVNILSKADLIEQFGELEFNLDYFTEVLDLQYLVDKINKNNDPFLAKYERLNQALISIIQDQSLVQFLLLDIQNVSHLERVMRYADRANGYVFGPDEQRNLQALMHSASGVELTPDWIGLAQEKYMSGVKQTEPDIDFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1T8</accession>
    <name>A0A074Z1T8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597002">
        <property type="protein sequence ID" value="KER21011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175234.1">
        <property type="nucleotide sequence ID" value="XM_009176970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1T8"/>
    <dbReference type="GeneID" id="20324730"/>
    <dbReference type="KEGG" id="ovi:T265_10562"/>
    <dbReference type="CTD" id="20324730"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="102" mass="11295" checksum="E5BEE36238D4E513" modified="2014-10-01" version="1">MTTVVNMVSLNDASQPMYCSPVTSQNAATDFTAPPVEFVCTAYDDWTWIAYNTQFVRINNSSTTNGVMHKNAQLGRLNTANAQLGGHLGLQSRRKNNDKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2X9</accession>
    <name>A0A074Z2X9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597122">
        <property type="protein sequence ID" value="KER19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176366.1">
        <property type="nucleotide sequence ID" value="XM_009178102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2X9"/>
    <dbReference type="STRING" id="6198.A0A074Z2X9"/>
    <dbReference type="GeneID" id="20325614"/>
    <dbReference type="KEGG" id="ovi:T265_11446"/>
    <dbReference type="CTD" id="20325614"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27316" checksum="F748B980061DB2CC" modified="2014-10-01" version="1">MTKYNPCGTCGFYDHVLFQQDGAVGQLLRRGSMFVYSSQQFGALLELTIEDRLHSLLDLGAGDGMVTAKMAPYFEQVYVTELSHTMQWRLSERGFTVIDADAWSKVSEDPESGSGCYDVVSCLNVLDRCDAPITMLEQISRVLKPDTGRLVLGIVLPLKQYVEITGDKCPSEVLEVSDSHIWEVQLNSLVSRVLKPAKFEVLRWTRVPYLCEGDFTQSFYYLNEAILVLRYRGGSRRESQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z449</accession>
    <name>A0A074Z449_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174376.1">
        <property type="nucleotide sequence ID" value="XM_009176112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z449"/>
    <dbReference type="GeneID" id="20324067"/>
    <dbReference type="KEGG" id="ovi:T265_09899"/>
    <dbReference type="CTD" id="20324067"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16036" checksum="EF1CD128AA6ADB9A" modified="2014-10-01" version="1">MRDSVNVAEIPPIIAQWIAQVRKPSHHGKVRGSNPTWASRLPLSVLGQPGSIPALVLPSGGMAARHRKGATAERFLSFSFYLLDTNYHRSFHPGRRCIECMLTLRQGLERCHSIKRSALVVFLDLKCAFDCRLSETLAVSGNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4K6</accession>
    <name>A0A074Z4K6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Headcase middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597055">
        <property type="protein sequence ID" value="KER20457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175787.1">
        <property type="nucleotide sequence ID" value="XM_009177523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4K6"/>
    <dbReference type="GeneID" id="20325158"/>
    <dbReference type="KEGG" id="ovi:T265_10990"/>
    <dbReference type="CTD" id="20325158"/>
    <dbReference type="OrthoDB" id="10012848at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase middle" evidence="2">
        <location>
            <begin position="682"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Headcase middle" evidence="2">
        <location>
            <begin position="919"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115859" checksum="8681686B88809E95" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4V0</accession>
    <name>A0A074Z4V0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603068">
        <property type="protein sequence ID" value="KER18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177918.1">
        <property type="nucleotide sequence ID" value="XM_009179654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4V0"/>
    <dbReference type="GeneID" id="20326470"/>
    <dbReference type="KEGG" id="ovi:T265_12302"/>
    <dbReference type="CTD" id="20326470"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="7933" checksum="5B6685044C453DA0" modified="2014-10-01" version="1">MGELAAVSNKQTEQHDLEEMRPHLATRHDGGGDGGANQATPTQFSATSVWNVTWTNTCVYLYAFLILGMHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z545</accession>
    <name>A0A074Z545_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Parvovirus non-structural protein 1 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601228">
        <property type="protein sequence ID" value="KER18445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177808.1">
        <property type="nucleotide sequence ID" value="XM_009179544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z545"/>
    <dbReference type="GeneID" id="20330217"/>
    <dbReference type="KEGG" id="ovi:T265_16052"/>
    <dbReference type="CTD" id="20330217"/>
    <dbReference type="OrthoDB" id="8300295at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Parvovirus non-structural protein 1 helicase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Parvovirus non-structural protein 1 helicase" evidence="1">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="32438" checksum="E89A6A3BFFE47EA3" modified="2014-10-01" version="1" fragment="single">MSIMATVQPVINWNHFAAYLVRAAQTPITCIGKKLEHLRDDLYMIPRERKDCATLLRDERSSRQKHNNITRKRRLDLMRELVRSYDARSFNELYKRLSVQDTDDIYAEYGPTWKETAEHSIANYCKEIILEQETMTFEQILNSNHHSRTCQHPADTTLGEQWLDQLIRVNNINKRELLACLTSVMNKLCTRKNAFVIEGPTTTGKTLFVKLVAENYEEPRITQLTVNDFKELLGGNPFDIHVKHQKDERLDRLPVLITTNNPLTYYVMDADGKAILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5G4</accession>
    <name>A0A074Z5G4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596906">
        <property type="protein sequence ID" value="KER22318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173935.1">
        <property type="nucleotide sequence ID" value="XM_009175671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5G4"/>
    <dbReference type="GeneID" id="20323732"/>
    <dbReference type="KEGG" id="ovi:T265_09563"/>
    <dbReference type="CTD" id="20323732"/>
    <dbReference type="OrthoDB" id="10452637at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17050" checksum="02721BB63FDE729C" modified="2014-10-01" version="1">MNSLKYEYIHILSSTLLKFEPLVLVNTHGQSTVGFALPGAHRICNFSGMSGRCRFPSILTRINCTVTVNDISPKVIIIIDSMTSVFNTNASVPYNHDLFESLTVQKRVKTFIQTIWIETDNKNATDIGWQPYVVVSPTRHSEDHAVPILEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z705</accession>
    <name>A0A074Z705_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173286.1">
        <property type="nucleotide sequence ID" value="XM_009175022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z705"/>
    <dbReference type="GeneID" id="20323232"/>
    <dbReference type="KEGG" id="ovi:T265_09053"/>
    <dbReference type="CTD" id="20323232"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="131" mass="14388" checksum="E2836A98E9FD0CDA" modified="2014-10-01" version="1">MRFHNTVGSPNTKEYQTVEQTRCLTAMHEVWHTARLPKPRQGKSTGRGRVGTTDLPINCQNLRGVFHPQRVSSITGNVMYQGHDPRESIQNFTVAGNRSALAPFRCLTAMPPEESTRAGILSGRPSLSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7S7</accession>
    <name>A0A074Z7S7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596953">
        <property type="protein sequence ID" value="KER21627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174630.1">
        <property type="nucleotide sequence ID" value="XM_009176366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7S7"/>
    <dbReference type="GeneID" id="20324263"/>
    <dbReference type="KEGG" id="ovi:T265_10095"/>
    <dbReference type="CTD" id="20324263"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="13690" checksum="36450CEC61B0561A" modified="2014-10-01" version="1">MKKTTHKVAENSSTAHCRFRPSWGSSSPRVFINLMFYPTLDCCKILGCTTIYTVRHTPPPSKKNGLSYSAMAQGLERKFTDWKVSASNPTSTFRLPLSRLGQPSSFPSPVIPSSGMAVRHRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8B0</accession>
    <name>A0A074Z8B0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596940">
        <property type="protein sequence ID" value="KER21797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174452.1">
        <property type="nucleotide sequence ID" value="XM_009176188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8B0"/>
    <dbReference type="STRING" id="6198.A0A074Z8B0"/>
    <dbReference type="GeneID" id="20324125"/>
    <dbReference type="KEGG" id="ovi:T265_09957"/>
    <dbReference type="CTD" id="20324125"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15833" checksum="B55A74D1D44FA444" modified="2014-10-01" version="1">MIIPEINDTVEIYIYTLPGKDVYSNLINKYVDHINMLMVVFDVTKKESFSSAQSALARFHPDAHCHSRPIVLVGNKMDLEARRVVSREEAEKFADSIGIPYYETSAKDALGVEAPFLHLVKEYHNLYIRKIETFQTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8K2</accession>
    <name>A0A074Z8K2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
    </comment>
    <dbReference type="EMBL" id="KL596932">
        <property type="protein sequence ID" value="KER21912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174334.1">
        <property type="nucleotide sequence ID" value="XM_009176070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8K2"/>
    <dbReference type="STRING" id="6198.A0A074Z8K2"/>
    <dbReference type="GeneID" id="20329148"/>
    <dbReference type="KEGG" id="ovi:T265_14982"/>
    <dbReference type="CTD" id="20329148"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00045213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="474" mass="52229" checksum="EED2EDD7D279656F" modified="2014-10-01" version="1" fragment="single">GWLAYGHLSFEEAVQPIAALNLIITTHEDAIDCLFLPGAVSMWTWDLVPATSEVYRDSPVFRATWFHYRAALKSNMHILLVACGTYDGAVFALAYIHDALEPNGPKILEPVLLDASAHVGPVTAISVEDPFIVSGSADEAIQLFSVPGQMRLGSLELHSGTIRHLEFCPKTSASEVAHLLSASDDGCIAIWRQKDLESEEKFNPASWECIRLLRRHKGPVRSLAIHPSLRCAYSISEDKTFRIWNLLRGRQAYATRLKLLAPGAEGVVASPSGRRLLFLWPNRFQLIDLFAPTSSDSDGPLGCLVADVLFPQPSTASPVFFNEDDHTDDHDSKEMDHSEKFAHVLTGFGPYLTAFRCPLSVGSDKKSTQKAENFGEIKLPGKRIKAIQVTSWPKSLHRVDDGMSDFRSRLVVVVTTESSGSHIRGYLINLSAPLASGVGFLPVFLHDVSAARVTTLSARWTEREEQIAIDDTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8U2</accession>
    <name>A0A074Z8U2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_09797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER22002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174238.1">
        <property type="nucleotide sequence ID" value="XM_009175974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8U2"/>
    <dbReference type="STRING" id="6198.A0A074Z8U2"/>
    <dbReference type="GeneID" id="20323965"/>
    <dbReference type="KEGG" id="ovi:T265_09797"/>
    <dbReference type="CTD" id="20323965"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16654">
        <property type="entry name" value="RING-Ubox_CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000124">
        <property type="entry name" value="STIP1 homology and U box-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045202">
        <property type="entry name" value="CHIP_RING-Ubox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="151" mass="17432" checksum="86C27E5637DC1937" modified="2014-10-01" version="1">MILRLQDSKPKGEYTPMNTVVSRFGPENGTFFILPVVCHNTCSFGCSVAADPENLKLLSHRFFFQVDSRRQKREVPEYLCGRISFELMLDPVITPSGITYDRRSILAHLRKVGHFDPISHQPLTENQLIPNRIMKEVVHAFLEENPWAENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAJ7</accession>
    <name>A0A074ZAJ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596815">
        <property type="protein sequence ID" value="KER24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171942.1">
        <property type="nucleotide sequence ID" value="XM_009173678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAJ7"/>
    <dbReference type="STRING" id="6198.A0A074ZAJ7"/>
    <dbReference type="GeneID" id="20322176"/>
    <dbReference type="KEGG" id="ovi:T265_07997"/>
    <dbReference type="CTD" id="20322176"/>
    <dbReference type="OrthoDB" id="6256667at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="323" mass="35561" checksum="D83F014F8B42702C" modified="2014-10-01" version="1">MASKPNHPADKKPPAFFIPASYKGNQVVPPISAKASLTVGIAESGQQLGNNVGLSSRVGTPLGTIGKVASTDSARSIPGKPGSYLLASPSGVLDLSLYNYVPVTEKSAGKHNGQSNSHGLANQDQPDGITHESKLTPTDGAETAVVEKEKKRRRFRRPRRNSKLDRLIRILEDKRVGDDEDGEELEDLQLPRLRRVLNIIFVTLGVCFLLAVITVILYTTIATAYMTVKINNHLFNKGNMPSRFKFKDYCPVVSKAVRARFGVNKLDYWDALTGHQPLWDSSRGKSGSKFLVTYNRQFAAKTIIPASFTFFCPLQTPDSIWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBX6</accession>
    <name>A0A074ZBX6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175549.1">
        <property type="nucleotide sequence ID" value="XM_009177285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBX6"/>
    <dbReference type="GeneID" id="20324976"/>
    <dbReference type="KEGG" id="ovi:T265_10808"/>
    <dbReference type="CTD" id="20324976"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="573" mass="61930" checksum="676BE945AF257F2E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCX1</accession>
    <name>A0A074ZCX1_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein G(q) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-q</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_07424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171206.1">
        <property type="nucleotide sequence ID" value="XM_009172942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCX1"/>
    <dbReference type="STRING" id="6198.A0A074ZCX1"/>
    <dbReference type="GeneID" id="20321603"/>
    <dbReference type="KEGG" id="ovi:T265_07424"/>
    <dbReference type="CTD" id="20321603"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF227">
        <property type="entry name" value="G PROTEIN ALPHA I SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER25028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="221" mass="25126" checksum="BA4912641AA99B4D" modified="2014-10-01" version="1">MGCAWSDPDKVQQDTSKAIEKQIRQDAEKAMKQVKLLLLGAGECGKSTVLKQMKIIHGQGYQESERKEYVCIIFANIVQSMIKILRAMESLEIAPDSFDPEVELKTLNGFLANVEDGHFPDDLANVLRRLWSCNSVQQCFARSKEYQLNDSAEYYMKSLDRIAAPGYTPTEQDVLRSRVKTTGIVESGFRYKDLEFKVFDVGKDMPTQKIMTALFIYRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDC0</accession>
    <name>A0A074ZDC0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596781">
        <property type="protein sequence ID" value="KER25291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170973.1">
        <property type="nucleotide sequence ID" value="XM_009172709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDC0"/>
    <dbReference type="STRING" id="6198.A0A074ZDC0"/>
    <dbReference type="GeneID" id="20328404"/>
    <dbReference type="KEGG" id="ovi:T265_14238"/>
    <dbReference type="CTD" id="20328404"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16387" checksum="4F856D937784A3AB" modified="2014-10-01" version="1" fragment="single">MTTQVHYQMAKSDLTSGNNDCLTTAKIQEASRTLEESESYDRKMLPKMERTALEEEEVGVGEDGEQHGDNQTNLIVNYLPQTMTQEEMRTMFSKIGKLTSCKLIRDRTSGQSLGYGFVNYVNASDARRAIKLLNRMRVQNKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDI4</accession>
    <name>A0A074ZDI4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596783">
        <property type="protein sequence ID" value="KER25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171014.1">
        <property type="nucleotide sequence ID" value="XM_009172750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDI4"/>
    <dbReference type="GeneID" id="20321451"/>
    <dbReference type="KEGG" id="ovi:T265_07272"/>
    <dbReference type="CTD" id="20321451"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="177" mass="19458" checksum="C4161B9E5F0D9737" modified="2014-10-01" version="1">MCLNHSAFSSSDSVLGISFFLSISRSVLPSRCCVRCCIVNCPTWNLSRKEPSPNGTGIACLDRVTGLERAHYSKDITMFVIEVNIGSSVCAIFLRTGRDKGQPSFDQITTEGMPSSKVTWASANGDTGQRSNQWNHPTEQLIATKGHPLLAARILTHAQHYPTHNHQPTATHYYAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDK2</accession>
    <name>A0A074ZDK2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA 3'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596979">
        <property type="protein sequence ID" value="KER21280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174976.1">
        <property type="nucleotide sequence ID" value="XM_009176712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDK2"/>
    <dbReference type="STRING" id="6198.A0A074ZDK2"/>
    <dbReference type="GeneID" id="20324529"/>
    <dbReference type="KEGG" id="ovi:T265_10361"/>
    <dbReference type="CTD" id="20324529"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45864" checksum="57899C29196C9CAA" modified="2014-10-01" version="1">MPGKRPSASNSSVGPTPKMLQTTLVPPQLNGNGQISRFWEVTKSLLIYTHPDCKSSSKIMGFDMDGTLITTASGKTFPKDANDWKLLNDRVVSKLKEYHAQGFKIVILSNQSGITMGYLDVAGFQRKFESIAFKLTVPLQAFFSLLSDRNRKPMIGMWEQLEEKGNDGIPIDKLASIYCGDAAGRPAEGSRKKDFSCSDRLFALNVGLPFRTPEELWYGQPAPKNFVLPKFNPHSVLKEGSGTKMPPLSRPKTPEIILMVGYPASGKSYFCQKTLAPLGYTVVSRDVLGTWQKCVKACEEAVARRTPVAVDNTNMDRESRARYIKIAQAAGIPIRCFIMQTELEHALHNEKFRVLTDNKHAPIGSMVFNMLKSKQQPPKIEEGFSELVSVPFLLDTTRSQISLYTKYLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF23</accession>
    <name>A0A074ZF23_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-hydroxyacyl-CoA lyase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IlvB-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-hydroxyhexadecanoyl-CoA = pentadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55212"/>
            <dbReference type="ChEBI" id="CHEBI:17302"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:138654"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55213"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172030.1">
        <property type="nucleotide sequence ID" value="XM_009173766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF23"/>
    <dbReference type="STRING" id="6198.A0A074ZF23"/>
    <dbReference type="GeneID" id="20322250"/>
    <dbReference type="KEGG" id="ovi:T265_08071"/>
    <dbReference type="CTD" id="20322250"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="10">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="9">
        <location>
            <begin position="438"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="622" mass="67796" checksum="200680C658309DD3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFC1</accession>
    <name>A0A074ZFC1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596930">
        <property type="protein sequence ID" value="KER21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174315.1">
        <property type="nucleotide sequence ID" value="XM_009176051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFC1"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20324021"/>
    <dbReference type="KEGG" id="ovi:T265_09853"/>
    <dbReference type="CTD" id="20324021"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000020">
        <property type="entry name" value="Clan CD, family C13, asparaginyl endopeptidase-like cysteine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704116" description="Peptidase C13 family protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70096" checksum="1142EE5BA7A44F2C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG49</accession>
    <name>A0A074ZG49_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170124.1">
        <property type="nucleotide sequence ID" value="XM_009171860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG49"/>
    <dbReference type="GeneID" id="20320743"/>
    <dbReference type="KEGG" id="ovi:T265_06564"/>
    <dbReference type="CTD" id="20320743"/>
    <dbReference type="OrthoDB" id="6250836at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33795" checksum="799CF5738C36A3EA" modified="2014-10-01" version="1">MNPIKPGSSLKHVPLFPTMVNNTIDLFSSTEGISMLLSPLTVFVLQAVLSTGSTCPPPYLQIDSDLCVVKVEQSGSFCSACEMCKRYGAARGHLTFLIGRNTRRVMPHLPNCTNLWLGFNWFLTTMNRSSVGWHDVDPRTPQYTTKGEEILWDLNDPSGTEPVVVSRCLTKTMFGCSVLCKLVPLSVYCEYGGQLPIENRQQLYRSDFPVQLKDNFILPSTKFLGCYQEIPTNSMIECAHKCTVNMQCRSFYFGQYNLRCVHTLHADSLLPSVFVMKAADWKRFAKIPYPDSRQIKHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGI3</accession>
    <name>A0A074ZGI3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169955.1">
        <property type="nucleotide sequence ID" value="XM_009171691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGI3"/>
    <dbReference type="STRING" id="6198.A0A074ZGI3"/>
    <dbReference type="GeneID" id="20320612"/>
    <dbReference type="KEGG" id="ovi:T265_06433"/>
    <dbReference type="CTD" id="20320612"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046660">
        <property type="term" value="P:female sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010519">
        <property type="entry name" value="Tra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06495">
        <property type="entry name" value="Transformer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="576" mass="64731" checksum="350679ACD8DF0C0B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGR9</accession>
    <name>A0A074ZGR9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169752.1">
        <property type="nucleotide sequence ID" value="XM_009171488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGR9"/>
    <dbReference type="GeneID" id="20320450"/>
    <dbReference type="KEGG" id="ovi:T265_06268"/>
    <dbReference type="CTD" id="20320450"/>
    <dbReference type="OrthoDB" id="6223842at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22648" checksum="D831D45471D6368B" modified="2014-10-01" version="1">MTRTYRKSPTDEGTSHVRLQDLFRVGVRPVVPLLPYPMWCVAACYKWTFTIISEHCVTHQIGKDHMMPGRFVLATAIFLVVFGCHLSSINASKLQRPKRWAWHEIQKCGKIQGYSCMNHSMCQEKYGRDDMMCFEVYPCLSSCIFAAQLMNMELLKQHIKQVVYDGIPLNTHPDPVGYIRSMNQKTGQTGTRGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGU7</accession>
    <name>A0A074ZGU7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_07522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171331.1">
        <property type="nucleotide sequence ID" value="XM_009173067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGU7"/>
    <dbReference type="STRING" id="6198.A0A074ZGU7"/>
    <dbReference type="GeneID" id="20321701"/>
    <dbReference type="KEGG" id="ovi:T265_07522"/>
    <dbReference type="CTD" id="20321701"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="77"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="188"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="311"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER24897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="454" mass="50005" checksum="60695F4567BB6007" modified="2014-10-01" version="1">MRILALASILPRAENIKSSATPFFHFCVSGERQPLTDKNKTDPGKLAESLDPVFQSVKLRQYMPTLTNGDIGKMDTFLFTSESVGEGHPDKLCDQISDAILDEFLRRDPEAKVACETFTKTGMILVGGEISSTAGVDLQTTVRKVVRSIGYDDVRKGLDYKSCNILTAIEQQSPDIAKGVHEGRRTEEIGAGDQGIMFGYATDETEECMPLTVVLAHALTKRLAYCRRNHILSWARPDNKAQVTVEYAHDNGACRPLRVHTIVISTQHDENVTLEQVRSDLMEQVVKAVIPPNLLDDRTIYHLNPAGRFVVGGPQSDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYAARWVAKSLVKAGLCRRVLVQLSYAIGISEPLAVYVDSYGTGTVSDKELLTIVTQNFDLRPGVIVNELDLRAPRYLQTAVYGHFGRPEFPWEQCKKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGY9</accession>
    <name>A0A074ZGY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169811.1">
        <property type="nucleotide sequence ID" value="XM_009171547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGY9"/>
    <dbReference type="STRING" id="6198.A0A074ZGY9"/>
    <dbReference type="GeneID" id="20320502"/>
    <dbReference type="KEGG" id="ovi:T265_06320"/>
    <dbReference type="CTD" id="20320502"/>
    <dbReference type="OrthoDB" id="6412411at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32859" checksum="704423A949440506" modified="2014-10-01" version="1">MLWNGMSSGALFGCWSVRRAWQLDCKRFITNRGSSGALFGCWSVHRAWQLDCKRFITNQGYIVSAGLSVTSIGDETFAIQLANSANRPTTKHFQLWRCNARQCRYEIGLRKGTWLDRSRMELRIVILFIYCWSKSLGKIKFCSKKLSTSHTTPVDWKKFLRDVCVWQLLQTPTVIGGPGLHVEIDETLISRRKNHAGRVPFQQSNCGHFDGHNPGLHRSRLNHHLRFVGIIKGAETMIEMNYTHETVNDTVVDPTTGAHTQTIESLWVAGVNFLAGLIWKRADGLKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHW6</accession>
    <name>A0A074ZHW6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169356.1">
        <property type="nucleotide sequence ID" value="XM_009171092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHW6"/>
    <dbReference type="GeneID" id="20320127"/>
    <dbReference type="KEGG" id="ovi:T265_05945"/>
    <dbReference type="CTD" id="20320127"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="88" mass="9671" checksum="C3FC328877DEFF9E" modified="2014-10-01" version="1">MVVRDATYSASGETGQSMRHWVSSQFGKLLDCRCRAHNGVHQLLRCSINLSLYVGREAGQSDRSARMNTANTGKDRNSSHASPMTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK35</accession>
    <name>A0A074ZK35_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
            <location evidence="2 10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596755">
        <property type="protein sequence ID" value="KER26132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170109.1">
        <property type="nucleotide sequence ID" value="XM_009171845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK35"/>
    <dbReference type="STRING" id="6198.A0A074ZK35"/>
    <dbReference type="GeneID" id="20320728"/>
    <dbReference type="KEGG" id="ovi:T265_06549"/>
    <dbReference type="CTD" id="20320728"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="16148" checksum="93D9CF2E85E1ABB5" modified="2014-10-01" version="1">MEGRDSKKAQVIKAEMDLELQDEAIHTAAEACDRYDELSEIIEFVKKEFDKKHGSSWHCFAGTSFCSYFTCEENCFINFSYDGREFLLFKTPTGSPYSTGTHKLHNEKTVSLKWLKREFTDRKVVGSNPTSAFRLLLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKQ5</accession>
    <name>A0A074ZKQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168595.1">
        <property type="nucleotide sequence ID" value="XM_009170331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKQ5"/>
    <dbReference type="STRING" id="6198.A0A074ZKQ5"/>
    <dbReference type="GeneID" id="20319522"/>
    <dbReference type="KEGG" id="ovi:T265_05340"/>
    <dbReference type="CTD" id="20319522"/>
    <dbReference type="OrthoDB" id="10493504at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="244" mass="27735" checksum="F3CC374C43227530" modified="2014-10-01" version="1">MQCRWTVSKTLADNIVLIFKEEGKAQVFLEELTKVIPSFGMNFAPIQCKVMLVDMRSLNTPLTIQGEVLKVVEHFTCLGSCISSDCSVTDEVNARICKARAAFANLRHLWRQSDLSLNLKGRVYQAAVWAILLCGSELRRLHVIDNRCLRTIARVGWCPRIHNEAVRKRVFGCATGTSIEEYVQHQKLCWLRTCVTYAEPSFAEESAVFHAQFRLPVKSQIWSTESDAVTPFLDRTTKNKIVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLE8</accession>
    <name>A0A074ZLE8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_05122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596711">
        <property type="protein sequence ID" value="KER27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168310.1">
        <property type="nucleotide sequence ID" value="XM_009170046.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZLE8"/>
    <dbReference type="GeneID" id="20319304"/>
    <dbReference type="KEGG" id="ovi:T265_05122"/>
    <dbReference type="CTD" id="20319304"/>
    <dbReference type="OrthoDB" id="6257178at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF19">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="418"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1396"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3143"/>
            <end position="3165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1653"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1873"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3143"/>
            <end position="3164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="3218" mass="366289" checksum="5A5D35CAE0043BE7" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM87</accession>
    <name>A0A074ZM87_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596736">
        <property type="protein sequence ID" value="KER26887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169355.1">
        <property type="nucleotide sequence ID" value="XM_009171091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM87"/>
    <dbReference type="GeneID" id="20320126"/>
    <dbReference type="KEGG" id="ovi:T265_05944"/>
    <dbReference type="CTD" id="20320126"/>
    <dbReference type="OrthoDB" id="10326554at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15171" checksum="7A13B0AD8ABE4E51" modified="2014-10-01" version="1">MLFKFFVSSRSHNSDKGSVATRDTEVSRENTRTHSHLSRARSKPKDHTSTSWPYFTSPASAFGSRELPQTDHPVTDDELIQSQLDRLHLQPVFFRRKYSKSPKPSRSRPPGSNSKLKTSTHSRSTEPVFAVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN04</accession>
    <name>A0A074ZN04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167742.1">
        <property type="nucleotide sequence ID" value="XM_009169478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN04"/>
    <dbReference type="GeneID" id="20327726"/>
    <dbReference type="KEGG" id="ovi:T265_13559"/>
    <dbReference type="CTD" id="20327726"/>
    <dbReference type="OrthoDB" id="10599282at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40319" checksum="555EB52FE7303DCF" modified="2014-10-01" version="1" fragment="single">QQAPQRKTNTLATCVGQVHRFGTNFTIVQPSPSANESTASRTNPVSWLSQDANKYLIIFLVKTMTVTVSSSGEFNAVGILRDSEPGKDRRSCRVSVDLTFYLNSNWTVFDKHTNLQINLVFTRDSTESLVCDILQLNMLHTGRLMFQLARYSRYRNFARVENVTRSDLSASGFVRISWNYTSDCPQTIGFRVVVYVGDKERATYHTSRNFIDIKVRNVCDTLVIVVSSYWQHKMIHARKTFGFSSAHNNFPKFRQNCAAGFLIFPVPNEPTDFIFRGQEGKWHISWHDSSQCPTSRYIVSVSNSLNQSVFSGNVTQREINIERLDFCADWFVSVTAVNEAGESPKAIKNLTAVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNW6</accession>
    <name>A0A074ZNW6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171229.1">
        <property type="nucleotide sequence ID" value="XM_009172965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNW6"/>
    <dbReference type="GeneID" id="20328454"/>
    <dbReference type="KEGG" id="ovi:T265_14288"/>
    <dbReference type="CTD" id="20328454"/>
    <dbReference type="OrthoDB" id="6243574at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="511"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="664" mass="74711" checksum="59C1BBA0726D4FEB" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP17</accession>
    <name>A0A074ZP17_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596690">
        <property type="protein sequence ID" value="KER28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167405.1">
        <property type="nucleotide sequence ID" value="XM_009169141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP17"/>
    <dbReference type="GeneID" id="20318584"/>
    <dbReference type="KEGG" id="ovi:T265_04402"/>
    <dbReference type="CTD" id="20318584"/>
    <dbReference type="OrthoDB" id="6273298at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="658" mass="71738" checksum="8FA5E8779E9915BA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQS6</accession>
    <name>A0A074ZQS6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596769">
        <property type="protein sequence ID" value="KER25680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170577.1">
        <property type="nucleotide sequence ID" value="XM_009172313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQS6"/>
    <dbReference type="GeneID" id="20321094"/>
    <dbReference type="KEGG" id="ovi:T265_06915"/>
    <dbReference type="CTD" id="20321094"/>
    <dbReference type="OrthoDB" id="6142323at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="171" mass="19513" checksum="17ACE62F69130AB3" modified="2014-10-01" version="1">MNSGVFMTFSRLPYCFTDDEIEKKWRNWISLSGSFWKDHHTLTRPEVTRFQLSRCQFAAYEQSKCFTDESGVKAGNAQRLFQLIRAAGPRKPPVSETIKHQNGTTISNKEERLDRFISLLHPTEMKENCLDHSEPFSKLNASPLSVLVLMAAVPMSSDVHQAPMHESPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR96</accession>
    <name>A0A074ZR96_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596701">
        <property type="protein sequence ID" value="KER28342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167904.1">
        <property type="nucleotide sequence ID" value="XM_009169640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR96"/>
    <dbReference type="GeneID" id="20318984"/>
    <dbReference type="KEGG" id="ovi:T265_04802"/>
    <dbReference type="CTD" id="20318984"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="152" mass="17180" checksum="6534CFC4D2FF9583" modified="2014-10-01" version="1">MPVHQWIIGMRFSNSRIETQFPPPSSQVCERRQLVQQARCEGACRNSAKRQRLLSRRHGTIACPTYTASLSAGLATEDSNGVTTTETACPFVVGLGPSTGRLVRKPEKYRRYSAANDAKKNIGHVLPWIIPKNQAEVYRQYFKLRRPKVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRA2</accession>
    <name>A0A074ZRA2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596764">
        <property type="protein sequence ID" value="KER25870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170398.1">
        <property type="nucleotide sequence ID" value="XM_009172134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRA2"/>
    <dbReference type="STRING" id="6198.A0A074ZRA2"/>
    <dbReference type="GeneID" id="20320960"/>
    <dbReference type="KEGG" id="ovi:T265_06781"/>
    <dbReference type="CTD" id="20320960"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="381" mass="43271" checksum="7DA02A7437356092" modified="2014-10-01" version="1">MAAGEDELEVTVRGTFFSCPPTSLVEPNTETVGGSQDMQLVEDENSKVHCVNYQRVKDFTHLMHTLAQSAEEYARQIWMRGWQVVHFQRLPTWLKDNEMLLRGHRPQLYTVWACFASIFRVHTETGNIWTHLLGCAGFIAISTFILLQPSALIQWQEKLIFSGFFFGAILCLGFSCLFHTVLCHSESISRILNKLDYCGIAFLTMGSFVPYLYYSFYCVLWLKLFYLALIFALGSGAIAVSMSNTFASPSYRPLRALVFIALGLSGVIPCVHVTITNGFWPSVQHGSLGWLFLMAVLYITGASIYAVRVPERIFPGRFDIWFQSHQIFHVFVVAAALVHYHGIIGLTNYRLAIGDCRPPPGYPFPKHDYDNIELLRPFMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRR5</accession>
    <name>A0A074ZRR5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL619571">
        <property type="protein sequence ID" value="KER18009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178244.1">
        <property type="nucleotide sequence ID" value="XM_009179980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRR5"/>
    <dbReference type="GeneID" id="20326569"/>
    <dbReference type="KEGG" id="ovi:T265_12401"/>
    <dbReference type="CTD" id="20326569"/>
    <dbReference type="OrthoDB" id="10539818at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="76" mass="8550" checksum="55C16541E035B2AB" modified="2014-10-01" version="1">MLGEDSEHEESGLYATDETSTNGEEEEADEDYEENGNTEGEVEICSTIDMYVLINVFRILNTKNTFVILGKWGPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSI6</accession>
    <name>A0A074ZSI6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605666">
        <property type="protein sequence ID" value="KER18229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178024.1">
        <property type="nucleotide sequence ID" value="XM_009179760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSI6"/>
    <dbReference type="STRING" id="6198.A0A074ZSI6"/>
    <dbReference type="GeneID" id="20330373"/>
    <dbReference type="KEGG" id="ovi:T265_16208"/>
    <dbReference type="CTD" id="20330373"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="55" mass="6282" checksum="F61C5BB85E6B884A" modified="2014-10-01" version="1" fragment="single">MLAANQAVARRLFQAFVQHFSSCSKPTVIDQFGQDVWPGALLRRHEEPSKKNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZST1</accession>
    <name>A0A074ZST1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165762.1">
        <property type="nucleotide sequence ID" value="XM_009167498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZST1"/>
    <dbReference type="GeneID" id="20317280"/>
    <dbReference type="KEGG" id="ovi:T265_03093"/>
    <dbReference type="CTD" id="20317280"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12142" checksum="13C50DF05D49DA11" modified="2014-10-01" version="1">MEGSEAERQIDGLRASIAPQLSPTINRITIVGPRVRAIKRTSALTVKPNNDEINRSAVASFQCPVAMHLERYTRTETLPCCPSLDGDNGGTRVRFEPQTFRLVSLRLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSV8</accession>
    <name>A0A074ZSV8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169747.1">
        <property type="nucleotide sequence ID" value="XM_009171483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSV8"/>
    <dbReference type="GeneID" id="20320445"/>
    <dbReference type="KEGG" id="ovi:T265_06263"/>
    <dbReference type="CTD" id="20320445"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10094" checksum="613B6716A44FE584" modified="2014-10-01" version="1">MDNSSSFVSVDREINSTVKWKLLGAGGTLVFRRFRPTDLCGKLTLAFQVKFSSVVWRSYVLALIVPKQAMWNTGGLDALLGWWSVRRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSX7</accession>
    <name>A0A074ZSX7_OPIVI</name>
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        <recommendedName>
            <fullName evidence="5">WD domain, G-beta repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596746">
        <property type="protein sequence ID" value="KER26490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169780.1">
        <property type="nucleotide sequence ID" value="XM_009171516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSX7"/>
    <dbReference type="STRING" id="6198.A0A074ZSX7"/>
    <dbReference type="GeneID" id="20328154"/>
    <dbReference type="KEGG" id="ovi:T265_13987"/>
    <dbReference type="CTD" id="20328154"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43815" checksum="4F5F47E7F44FA2F4" modified="2014-10-01" version="1" fragment="single">RGHTDSVATLTLNDRILASGGDDGNVYFWCLDQSSFPVQHIPRRSPCSAVKFDLDKSDVLYSAHGNRIYTWDLRYLCEPLSEWKVNEDEVNYIDVLKGESRLAAADDSGAVQIFDTSSGEVVRTLKKHDNICSVAKFRPMRSWQLISGGLDCRVIVSDWKGTGRSVIIFELDEIINSDLFEDPQPVPTHSNEFANRASSESQASTSEYAEVEFDEFVETDEEADDPDEGELATTHPLSSGHVDSLSVRSRGGDSASGDPHVSEFERGHSDTNISELLNWQLSEQPDSSDIAPTSIAAQDAWISGLPINPPMVHSLACSASGDFVAAGLEKSTIELFSGDGKRLSHRESLYGHRRAVSALHFIGDSHLVSGGNDYRLFVWTLGVDVDGRELLHDAKVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU58</accession>
    <name>A0A074ZU58_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598304">
        <property type="protein sequence ID" value="KER18729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177524.1">
        <property type="nucleotide sequence ID" value="XM_009179260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU58"/>
    <dbReference type="STRING" id="6198.A0A074ZU58"/>
    <dbReference type="GeneID" id="20330028"/>
    <dbReference type="KEGG" id="ovi:T265_15863"/>
    <dbReference type="CTD" id="20330028"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="570" mass="57522" checksum="1D7917DB10B56593" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV61</accession>
    <name>A0A074ZV61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165270.1">
        <property type="nucleotide sequence ID" value="XM_009167006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV61"/>
    <dbReference type="STRING" id="6198.A0A074ZV61"/>
    <dbReference type="GeneID" id="20316892"/>
    <dbReference type="KEGG" id="ovi:T265_02704"/>
    <dbReference type="CTD" id="20316892"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="167" mass="19172" checksum="CABA1F115377D239" modified="2014-10-01" version="1">MALLQRWEDFIVQELANGELATLTTLDPIAPPAPSEEDIDESNNENNPILETYKVELGELLAGKRDCVKILVEKFFVQLIAPNFRHRNPRLPGLPFTKHYVLSLRNSPVLRSRKKSIPLAISWYQELASPQMFVSLNERITYYRKDIGIVVLCYIKKARTLLAPFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVR5</accession>
    <name>A0A074ZVR5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597267">
        <property type="protein sequence ID" value="KER19259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176995.1">
        <property type="nucleotide sequence ID" value="XM_009178731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVR5"/>
    <dbReference type="GeneID" id="20329768"/>
    <dbReference type="KEGG" id="ovi:T265_15603"/>
    <dbReference type="CTD" id="20329768"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="284" mass="31725" checksum="54B6AE107CFE3917" modified="2014-10-01" version="1" fragment="single">MTVKYEQGLGKEKPQNVICDLAEGKFGSKAFDQLAQNDIPKNVQALVDLQAESGSPDQLLDEISLHHQVEPPIVACIPQQLSQSFPKLSIEVFSTTFMDSTFRKENVGSSGIVDGGRWLVRTTTNPPLRTTTLHNNALMMSPRLVMKRLQSNCPAQRTSQRPPFIIVTIFAWANIHLPTLESSVDGCTADDGRVRSSYNNPELEQTTILETMPLCTWRAGLWMNKDVSQMDQPLAYQGNRTTLAWNAVSRDVVCRRVSQDGTHSVHRTHNLLPHRAYCPGARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVW0</accession>
    <name>A0A074ZVW0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164946.1">
        <property type="nucleotide sequence ID" value="XM_009166682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVW0"/>
    <dbReference type="GeneID" id="20316621"/>
    <dbReference type="KEGG" id="ovi:T265_02433"/>
    <dbReference type="CTD" id="20316621"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="8093" checksum="A592BCC177FCCBE2" modified="2014-10-01" version="1" fragment="single">GAYRTWTKLIFRPTPLLCIQTSHTPHGESAHTQKGSSGPHGRCQAYETTADPRKFSTTCQPRLLHLTFASLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWB5</accession>
    <name>A0A074ZWB5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597193">
        <property type="protein sequence ID" value="KER19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176751.1">
        <property type="nucleotide sequence ID" value="XM_009178487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWB5"/>
    <dbReference type="GeneID" id="20329688"/>
    <dbReference type="KEGG" id="ovi:T265_15523"/>
    <dbReference type="CTD" id="20329688"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705372" evidence="1">
        <location>
            <begin position="22"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="35761" checksum="950A80C757FCCBA8" modified="2014-10-01" version="1" fragment="single">MHVRLAPIVLWLDLRLAPTNSPSNTESQAAKRRSNPATDVLRRLRMLIFDGDSTMALAYNSESVFHVVSDGDDVRFKIGANLTASSRVGWQFSPSLNDAYLLSRRGMTPNRRLFSLFGFIHFKPPTNHFNGKSDRKMKPTDHNIKLHPTNNQDVHSGYFPATGGPGLEDQAFQLRRTMSQTFCRLFRVLELKCNMVFFATIDGVGITNAVPGFGIHCGPTNLDLSSLRMPCSPTYGSEEYSGNGFKVPSFFPPSRLAGLDGTNVGPIIIDLGNAAVPNFIVLGPPGARGSPSAQGFPSNASRVRHVEINGFRPFSLAIWSLICASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWF7</accession>
    <name>A0A074ZWF7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164774.1">
        <property type="nucleotide sequence ID" value="XM_009166510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWF7"/>
    <dbReference type="STRING" id="6198.A0A074ZWF7"/>
    <dbReference type="GeneID" id="20327129"/>
    <dbReference type="KEGG" id="ovi:T265_12961"/>
    <dbReference type="CTD" id="20327129"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="96801" checksum="F88BD79388A80226" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWJ5</accession>
    <name>A0A074ZWJ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596717">
        <property type="protein sequence ID" value="KER27705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168579.1">
        <property type="nucleotide sequence ID" value="XM_009170315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWJ5"/>
    <dbReference type="GeneID" id="20319514"/>
    <dbReference type="KEGG" id="ovi:T265_05332"/>
    <dbReference type="CTD" id="20319514"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="95" mass="10657" checksum="243D9A754DC30B47" modified="2014-10-01" version="1">MPKPLVLSKAQESFQKLHWNSPKISVRSIDQLDVELISLVHQTNRSTNHMPVDLIGRRGCRSPTPQHPGRVLYGVSDLGFRVKDSTSLVDKLNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX04</accession>
    <name>A0A074ZX04_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_03075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165744.1">
        <property type="nucleotide sequence ID" value="XM_009167480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX04"/>
    <dbReference type="STRING" id="6198.A0A074ZX04"/>
    <dbReference type="GeneID" id="20317262"/>
    <dbReference type="KEGG" id="ovi:T265_03075"/>
    <dbReference type="CTD" id="20317262"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046620">
        <property type="term" value="P:regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21774">
        <property type="entry name" value="MobB_LATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05598">
        <property type="entry name" value="STKc_LATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000391">
        <property type="entry name" value="Large tumor suppressor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000057">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122037" checksum="09C2E05AA465358F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX70</accession>
    <name>A0A074ZX70_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_13681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596710">
        <property type="protein sequence ID" value="KER27955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168294.1">
        <property type="nucleotide sequence ID" value="XM_009170030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX70"/>
    <dbReference type="STRING" id="6198.A0A074ZX70"/>
    <dbReference type="GeneID" id="20327848"/>
    <dbReference type="KEGG" id="ovi:T265_13681"/>
    <dbReference type="CTD" id="20327848"/>
    <dbReference type="OrthoDB" id="9943255at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="776"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="819" mass="89118" checksum="793DAED1A1605700" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXB0</accession>
    <name>A0A074ZXB0_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597132">
        <property type="protein sequence ID" value="KER19829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009178164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXB0"/>
    <dbReference type="STRING" id="6198.A0A074ZXB0"/>
    <dbReference type="GeneID" id="20325663"/>
    <dbReference type="KEGG" id="ovi:T265_11495"/>
    <dbReference type="CTD" id="20325663"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="96635" checksum="23D81FB9A4EA30AC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXJ2</accession>
    <name>A0A074ZXJ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164452.1">
        <property type="nucleotide sequence ID" value="XM_009166188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXJ2"/>
    <dbReference type="GeneID" id="20316228"/>
    <dbReference type="KEGG" id="ovi:T265_02040"/>
    <dbReference type="CTD" id="20316228"/>
    <dbReference type="OrthoDB" id="10400447at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="19503" checksum="D7C6940A1CE7AC44" modified="2014-10-01" version="1">MPIASLQLIPQRLPHSLRAPVLKMGTTTDSPQLSGDVSFSEIITDLISLGDPRDTSEAPTAKHLVIKDQHAAATHLIHKCACLRQALTDEFTVSVAYARSVDKLPFRHTRLCTLIEETVLGNPVSKGCCRQDLDKEIQKWFGNARHRLAQRTRMDQLATSVLNQEAGVFELDVPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXS2</accession>
    <name>A0A074ZXS2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163991.1">
        <property type="nucleotide sequence ID" value="XM_009165727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXS2"/>
    <dbReference type="GeneID" id="20315849"/>
    <dbReference type="KEGG" id="ovi:T265_01661"/>
    <dbReference type="CTD" id="20315849"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="296" mass="33928" checksum="533C16C189985C54" modified="2014-10-01" version="1">MFIGEENNMKINFSLEKTTHTVGENPSKTYGRFRPFLVLKGDSTEFRPSADWKASTNGVKHSVTFPMQRQWKLTEEQTCERKTEFRLQARRARENQLSRSSVGFHTDTALRLAVGRCYGQNTYPAEDWLVHQATKGHKWTWIECQRTFDPIKSMLSSDFLPIHCNPSLQKTTAHAVRALTSAQRNYSHIENESLAIVRESRCISLTTSSDGPLRLWDTTSRSTTSPPRVSDKPTHCRDSLIQASQNQRILVATIALEAEVNRVVSEAVRQATDQDPVLRQVIENRRNQWPRTCPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY72</accession>
    <name>A0A074ZY72_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164184.1">
        <property type="nucleotide sequence ID" value="XM_009165920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY72"/>
    <dbReference type="GeneID" id="20315998"/>
    <dbReference type="KEGG" id="ovi:T265_01810"/>
    <dbReference type="CTD" id="20315998"/>
    <dbReference type="OrthoDB" id="10626376at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="329" mass="36844" checksum="7071BA45902A4A10" modified="2014-10-01" version="1">MRHLRSLTEIQSATECAAPGRLILQSIGYSRYRDTYKFLYFTTQKLLKTPRQPTTGFAFHLETSEPRDSAGFQQNCRPFKYLVERDLGAYAHTGLEVSTTFNCQLFGQCNSGPAKSPVLRALADTPSSPIPSNLTEFQTLALANIHPSSEENDICVGQLTGLSTSRHHASSFDDLKQIRVESLINPHAKESRKGHILVRRVKCFKLANAIRALEISAFTSSVTLKSERIRIPRCAKCSKTSSTSPWIVSAVLSGRMSASTILHFVGTKMPTNGRYNFGQFIQKHISLLLFEDENDVVRIEKVFVTGYLNTGVLEIFQYSSHEPIDHQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZI8</accession>
    <name>A0A074ZZI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167574.1">
        <property type="nucleotide sequence ID" value="XM_009169310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZI8"/>
    <dbReference type="STRING" id="6198.A0A074ZZI8"/>
    <dbReference type="GeneID" id="20318728"/>
    <dbReference type="KEGG" id="ovi:T265_04546"/>
    <dbReference type="CTD" id="20318728"/>
    <dbReference type="OrthoDB" id="428774at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000186">
        <property type="entry name" value="Secretagogin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="301" mass="35263" checksum="1EE1F706190F95B5" modified="2014-10-01" version="1">MATKPHSGNYLSQFKDHNLNKMKLFTAAQFVEVWHHYDSDGNGYIEGKELDKFLREFISSVFSDELGGEVIAEDDLELMKKEFMKTFDENSDNRIELCELAKILPTEENFLVLFHQDNPLESSVEFMRIWKQFDKDRSGFIEADELKEFLRHLLKKAKPNEEIDEAKLQEYTSSILKLFDQNKDGKLQLSEMARLLPVKENYLCRPIFKNASKITSEDIDRAFSLYDLDGNNTIEDEELSGFLKDLMELAQEDYDENDLEFFKGTILSQWDVNNDGKINREELKMMLLQQSRLMSRGQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Q8</accession>
    <name>A0A075A0Q8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596641">
        <property type="protein sequence ID" value="KER31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164466.1">
        <property type="nucleotide sequence ID" value="XM_009166202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Q8"/>
    <dbReference type="GeneID" id="20316242"/>
    <dbReference type="KEGG" id="ovi:T265_02054"/>
    <dbReference type="CTD" id="20316242"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="15785" checksum="C148FE40B659BC59" modified="2014-10-01" version="1">MSPEDSERTVLSVSLGRAPALPSSMSVCSPRRRQYSSQSLRIPASMRSSSRRAPIHHRSEDRPLDARKLGHNRSGVEARNRLPPTAKPDDPKLITKPIVVISPCERQPLTDKNKTDPGNLGKSLAPVYQSVNPRIMAKLEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A115</accession>
    <name>A0A075A115_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167042.1">
        <property type="nucleotide sequence ID" value="XM_009168778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A115"/>
    <dbReference type="GeneID" id="20318306"/>
    <dbReference type="KEGG" id="ovi:T265_04120"/>
    <dbReference type="CTD" id="20318306"/>
    <dbReference type="OrthoDB" id="10366250at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="9988" checksum="0E081F6CBA679E7E" modified="2014-10-01" version="1">MQFKAEFPAVPSVAPSEPGDVGGEDLVQKDLAERSSKSRIVTIRLPFDESTIPVAGRKSLPLKNAPSAVLAQSSLVRNERDLNRSAGLFPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1I3</accession>
    <name>A0A075A1I3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163048.1">
        <property type="nucleotide sequence ID" value="XM_009164784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1I3"/>
    <dbReference type="GeneID" id="20315077"/>
    <dbReference type="KEGG" id="ovi:T265_00889"/>
    <dbReference type="CTD" id="20315077"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="70" mass="7851" checksum="1BE0B7AADFD636FB" modified="2014-10-01" version="1">MLISCENYQAGSNDMRSKSRTIKINGAEALEDDIQGHPAKKRKSEGLPPYGEAAVEKPTTRSDKRRQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1V8</accession>
    <name>A0A075A1V8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596970">
        <property type="protein sequence ID" value="KER21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174851.1">
        <property type="nucleotide sequence ID" value="XM_009176587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1V8"/>
    <dbReference type="GeneID" id="20324435"/>
    <dbReference type="KEGG" id="ovi:T265_10267"/>
    <dbReference type="CTD" id="20324435"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6722" checksum="CCB4475FA7CA78FF" modified="2014-10-01" version="1">MKCERTDGKQQAFDQLVWLKKRSTALTLDESMRAGIIPGFSSLDRGIPEAEVEFESRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A228</accession>
    <name>A0A075A228_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174793.1">
        <property type="nucleotide sequence ID" value="XM_009176529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A228"/>
    <dbReference type="STRING" id="6198.A0A075A228"/>
    <dbReference type="GeneID" id="20324388"/>
    <dbReference type="KEGG" id="ovi:T265_10220"/>
    <dbReference type="CTD" id="20324388"/>
    <dbReference type="OrthoDB" id="6250524at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="840" mass="93224" checksum="9ABBD39C8701C2C2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2K9</accession>
    <name>A0A075A2K9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_12526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162426.1">
        <property type="nucleotide sequence ID" value="XM_009164162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2K9"/>
    <dbReference type="STRING" id="6198.A0A075A2K9"/>
    <dbReference type="GeneID" id="20326694"/>
    <dbReference type="KEGG" id="ovi:T265_12526"/>
    <dbReference type="CTD" id="20326694"/>
    <dbReference type="OrthoDB" id="424249at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22426">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="401" mass="44251" checksum="63BE2D4649A171A9" modified="2014-10-01" version="1" fragment="single">MAPEALQPETPVKDQDDETYELKARLLVISPDVSTVKRAAVIDNTFIDMLRQKVLILQQTEELSRKLEASRVSQIAAPFIEEVYVPEHLIPYAIGFQGSNIRRASNIEGVFSIKLNRSTWTFQISGKSKEAVLQARALLDYTTEVIPVPRTYVGPIVGSGQRHIQHIVDCVGLSGLKICDMPEEKMENFVAFHLTGTSQAIRDARMFLEFHVASLQDLDRLRGVKNPPTLPAKKDAEPENHFPAEEAEGSGDVTSATGVRQKGGRSSQRSRRRPPPSSNQGTLSNGDSTIPQTETYEDVRTNEPASTENLEESGRQTSKPRQRRPQHVQAKNNSALSKHGGEDHSTRPTSDQPKINHVGSDNRGERLVNGTAPRGSFSRQNHRGDFHQPGTPVAAPVPAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2V2</accession>
    <name>A0A075A2V2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174562.1">
        <property type="nucleotide sequence ID" value="XM_009176298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2V2"/>
    <dbReference type="GeneID" id="20324212"/>
    <dbReference type="KEGG" id="ovi:T265_10044"/>
    <dbReference type="CTD" id="20324212"/>
    <dbReference type="OrthoDB" id="6250977at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="93742" checksum="FE626FA50C2D283E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A365</accession>
    <name>A0A075A365_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163611.1">
        <property type="nucleotide sequence ID" value="XM_009165347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A365"/>
    <dbReference type="STRING" id="6198.A0A075A365"/>
    <dbReference type="GeneID" id="20315529"/>
    <dbReference type="KEGG" id="ovi:T265_01341"/>
    <dbReference type="CTD" id="20315529"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000126">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="46913" checksum="AD8D80EFB5525769" modified="2014-10-01" version="1">MDTTSLHAMVLPIIVPPPWVLLHAFREIKRSQLGRKEDDCSEMHGPYRSDCILYERLPQENTVAGSATLQTNFGEFTLNCLTELSKAQCSTEKQWHRVRDAHRTMVTFPSSESPLRPTCATPCNKFFETPMAEKHNLGDQLNKSDTINSADGMQSGSHFKGFERVERGFCCPYCTKRFTSNSGLKQHMHIHSSFKPFTCQVCHKSYTQFSNLCRHKRLHKRCRQRMPCSECGHEFANSYSLLKHQILWGCRCRAVRRRGAMYSRKRDATPQLVSNQTSETNAEEVVPNLKSEMVSPVYHDISRLLHSKLRHYNRATHKKEESATGYSGEASHLQLDEGELSAMTSPSTARLHFSSLGSPAVTLYPCLAAMPPERNTRAEILSDCPSLDRRVLEAEVGFEPRTFWSVNSRSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3L1</accession>
    <name>A0A075A3L1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596666">
        <property type="protein sequence ID" value="KER30135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166129.1">
        <property type="nucleotide sequence ID" value="XM_009167865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3L1"/>
    <dbReference type="STRING" id="6198.A0A075A3L1"/>
    <dbReference type="GeneID" id="20317583"/>
    <dbReference type="KEGG" id="ovi:T265_03396"/>
    <dbReference type="CTD" id="20317583"/>
    <dbReference type="OrthoDB" id="10610849at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705430" evidence="1">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="222" mass="24348" checksum="763B80C790CB0C64" modified="2014-10-01" version="1">MFWNLGSSCALLGCLSVRRAWQLGCKRFITNRGDIVSAGLRDDVISNGEETFATQLPSSANRQTTKAVLNTGDLITFRKNGIIDAADDVVGVYHDTCGNCEAVLLPSCEDNVKEKFLKVENVVRFCRFKSPTLCAVGSVVSSNVFTHTDMGTTTKHTTTTANLKLAEPDDPLNPALTMSPQLMMKRLPSNCQARRTDQQPNNAPELPTFHHNIGCIHDDANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3Q8</accession>
    <name>A0A075A3Q8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MBOAT family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_01192</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163417.1">
        <property type="nucleotide sequence ID" value="XM_009165153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3Q8"/>
    <dbReference type="STRING" id="6198.A0A075A3Q8"/>
    <dbReference type="GeneID" id="20315380"/>
    <dbReference type="KEGG" id="ovi:T265_01192"/>
    <dbReference type="CTD" id="20315380"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="78100" checksum="4642121D28E01584" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A401</accession>
    <name>A0A075A401_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163328.1">
        <property type="nucleotide sequence ID" value="XM_009165064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A401"/>
    <dbReference type="STRING" id="6198.A0A075A401"/>
    <dbReference type="GeneID" id="20326882"/>
    <dbReference type="KEGG" id="ovi:T265_12714"/>
    <dbReference type="CTD" id="20326882"/>
    <dbReference type="OrthoDB" id="10542925at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="97" mass="11021" checksum="49691EDC166CA370" modified="2014-10-01" version="1" fragment="single">VLLIRLLKIHRQPTIGFALLGTHQAQSPGFRQPYVLCEIKLHEIINERFSWVPVIKNKSYYNRFSALTVVGFATKAVSANPISIFETFAYPDTSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4G2</accession>
    <name>A0A075A4G2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162022.1">
        <property type="nucleotide sequence ID" value="XM_009163758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4G2"/>
    <dbReference type="GeneID" id="20314289"/>
    <dbReference type="KEGG" id="ovi:T265_00101"/>
    <dbReference type="CTD" id="20314289"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9933" checksum="6126ED511058CF70" modified="2014-10-01" version="1">MKKPSNVTLLPADEAEAVEFVAPILLRQWEFVELATQKKANYWVRSQVPKKYFVSMYRRRDDGGNENCAEPCCGYLAQHVDPDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5Y0</accession>
    <name>A0A075A5Y0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596876">
        <property type="protein sequence ID" value="KER22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173386.1">
        <property type="nucleotide sequence ID" value="XM_009175122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5Y0"/>
    <dbReference type="GeneID" id="20323304"/>
    <dbReference type="KEGG" id="ovi:T265_09125"/>
    <dbReference type="CTD" id="20323304"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="8873" checksum="F9194B0CFF42DD14" modified="2014-10-01" version="1">MPFLPSDCTIIVVLLDMDLLRFYPSLVKNGGIGLNRIVVAGQHMRLYTQLTGPTTKPVGDSVPTLQVISAIQYETQQENVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A634</accession>
    <name>A0A075A634_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_00451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162488.1">
        <property type="nucleotide sequence ID" value="XM_009164224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A634"/>
    <dbReference type="STRING" id="6198.A0A075A634"/>
    <dbReference type="GeneID" id="20314639"/>
    <dbReference type="KEGG" id="ovi:T265_00451"/>
    <dbReference type="CTD" id="20314639"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="109079" checksum="E4667E70ACF72FA8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6N1</accession>
    <name>A0A075A6N1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165000.1">
        <property type="nucleotide sequence ID" value="XM_009166736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A6N1"/>
    <dbReference type="GeneID" id="20316675"/>
    <dbReference type="KEGG" id="ovi:T265_02487"/>
    <dbReference type="CTD" id="20316675"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="181" mass="19542" checksum="0FE276CCBEC04E6D" modified="2014-10-01" version="1">MAVTHFSVPIWQEIVIQSSSIKQPIRLGGTKSVGSSCHRASSYRISDQYPNYKQIIGSLSGVFGLIRLARKLTPDCTPHASRRATVMLIPQRQSRACTCLPTDLIGCSEAAEAKDVGVGIALSNRAEGCLLEWIPVDHLWQSGNALEAGIESSMIVSLKKLKTKDEKGQPCLPLDIANPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8F3</accession>
    <name>A0A075A8F3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596837">
        <property type="protein sequence ID" value="KER23739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172495.1">
        <property type="nucleotide sequence ID" value="XM_009174231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8F3"/>
    <dbReference type="STRING" id="6198.A0A075A8F3"/>
    <dbReference type="GeneID" id="20322609"/>
    <dbReference type="KEGG" id="ovi:T265_08430"/>
    <dbReference type="CTD" id="20322609"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="734" mass="79768" checksum="08306F0CC246E86F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA05</accession>
    <name>A0A075AA05_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163646.1">
        <property type="nucleotide sequence ID" value="XM_009165382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA05"/>
    <dbReference type="STRING" id="6198.A0A075AA05"/>
    <dbReference type="GeneID" id="20326931"/>
    <dbReference type="KEGG" id="ovi:T265_12763"/>
    <dbReference type="CTD" id="20326931"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000043">
        <property type="entry name" value="AGAP008687-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47772" checksum="C9CA977242B4EA03" modified="2014-10-01" version="1" fragment="single">DFILFEFKDEVGALVIDFGSHSLRAGFAGEDTPKMDMPSLVGTIPATDTKPVRRIVGQNVMVARGGMELQSFLKDGLSRFHPLFLIPGLVEDWDVFEDVMQYILQYLVPEESNHHPILFSEPAWNTKNHREKIAEVLFEKFKIPAFYVAKNAALTCFANGRHTGLVLDSGAIHTSAIPVYDGLVLTQETVRSPLAGDFLLQQAQRLMDELNVELVPYYKVASKEPVNEREPAKWKKRTNLPETTTSYENFMIKNLLQDFVASVLQVSDERYDQSQADTFPMVGYEFPNGYNFELGHERFQIPEALFDPSILQESGGSSMLSMSHIVASSISLCDIDIRPSLYSNVVVVGGTSLITGFTDRLQRDLNMKTPPSMRLKVNFPSTVVERRYSSWIGGSILGSLGTFQQMWISSHEYSELGKGCVDKKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABA6</accession>
    <name>A0A075ABA6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171350.1">
        <property type="nucleotide sequence ID" value="XM_009173086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABA6"/>
    <dbReference type="GeneID" id="20321720"/>
    <dbReference type="KEGG" id="ovi:T265_07541"/>
    <dbReference type="CTD" id="20321720"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10146" checksum="4AD4509F82A27955" modified="2014-10-01" version="1">MTWGGMILLKAYDVKNPRSEHSNLRFFNVTGVYKLVFSCSQKSYFVHRTASTVSHFEGFVGTYVLETLLEEADNKVLLTESTVVYAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABI8</accession>
    <name>A0A075ABI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pellino</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163025.1">
        <property type="nucleotide sequence ID" value="XM_009164761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABI8"/>
    <dbReference type="STRING" id="6198.A0A075ABI8"/>
    <dbReference type="GeneID" id="20315054"/>
    <dbReference type="KEGG" id="ovi:T265_00866"/>
    <dbReference type="CTD" id="20315054"/>
    <dbReference type="OrthoDB" id="8801906at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="5">
        <location>
            <begin position="122"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="6">
        <location>
            <begin position="336"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58683" checksum="D7D3CFC7FA2F7EC8" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABN3</accession>
    <name>A0A075ABN3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171193.1">
        <property type="nucleotide sequence ID" value="XM_009172929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABN3"/>
    <dbReference type="GeneID" id="20328448"/>
    <dbReference type="KEGG" id="ovi:T265_14282"/>
    <dbReference type="CTD" id="20328448"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="213" mass="23438" checksum="2E03393258FB4D30" modified="2014-10-01" version="1">MIPTTADSTAVAFGPPKVRSRMQLENGEALVQLLCLRHEFLFLTHRTQCQIVNISVSIDVIASDDDGVVLSSSQLAGGEMAQWLKRKFTDQKIRGSNLTFASRLPLSGLCLSVSQPSGFLWVAWQLGTEWVLQLSDLFSAGSLSSRHKGTVGIVVAGAELEIPQLLKCESMTRISAVITSTVSVIIEKIYTAFLQLSHLWILHNIRLSMKDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD25</accession>
    <name>A0A075AD25_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Decaprenyl-diphosphate synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170472.1">
        <property type="nucleotide sequence ID" value="XM_009172208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD25"/>
    <dbReference type="STRING" id="6198.A0A075AD25"/>
    <dbReference type="GeneID" id="20321013"/>
    <dbReference type="KEGG" id="ovi:T265_06834"/>
    <dbReference type="CTD" id="20321013"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48361" checksum="25EC22F7F59096BD" modified="2014-10-01" version="1">MMSNKWKNLIVQAEKLLGGPAPFINLSSLLTSEVEFLASRARRLAGTVDHPFFSAVRACFQGRSGNYPFLPLSLKSFGPVNRGNLTQRAPCGLIILLAGQCSAGNLGKSSVKLSNQYRKLAEVFETVHLAVTIHKSLVDPSSLKHISTSGNNGSNEVNGRSLVKDWEAGNKVATLVGDVLLASVSTTLAEFRNTQVLDVVSESIGNMFEAEFLPFAMNFSHGSSASSGQLGLSTDQATDQWLNYIGMSHGSLLGSCCQATLLLAGTSGKKQSGSSETGHSSHLVHKLGYNWALLLRLLEEREFVHHIWANKTKYVSSTSFLNANAAVFPPRLRVLNYINNGLPEPTLLDAVMTQQRTTESAETLLADGFTTALLPQHASRIFNAYDQLGQKLANNLSQVFDEFSAISQLTRERASSSALNVLGEMTHQLSSEACLRLTPVVNVMSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD47</accession>
    <name>A0A075AD47_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_12478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162266.1">
        <property type="nucleotide sequence ID" value="XM_009164002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD47"/>
    <dbReference type="GeneID" id="20326646"/>
    <dbReference type="KEGG" id="ovi:T265_12478"/>
    <dbReference type="CTD" id="20326646"/>
    <dbReference type="OrthoDB" id="117690at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="341" mass="38664" checksum="E36D56C18B6FBDFF" modified="2014-10-01" version="1" fragment="single">MIMMDHHSESSEHNRKMEGGGEMNASIRMPAHSLPPVGNNQHATYEQFNLNSIHHQDQHAERSQSTMSIGRYPSAYPHQSFRALPVRHSTRWGLKSGAKKSFVWKYFFHPEISLGVRDLSHTQCTLCDSQLAFNTSGTTTTMLNHLKSRHMEVVENEQQHHQKQRLPHHQRRDEEQNQHGHKYLSQSSGYSSAIGSVKTPRNSWIATDNSYSLKTCGYMRAPFLRRAHRGRPPNSWTKSSYAEKGSLESYSEKLSYTEPASRDGLLQKTSVTDVSEIHQFRQTTEINSKGAGGPPNSAVIQPADGVMHEPPWPSSSNHEGAQQPNFSDPMEMFRLSILMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEU6</accession>
    <name>A0A075AEU6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169202.1">
        <property type="nucleotide sequence ID" value="XM_009170938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEU6"/>
    <dbReference type="GeneID" id="20320013"/>
    <dbReference type="KEGG" id="ovi:T265_05831"/>
    <dbReference type="CTD" id="20320013"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="140" mass="16047" checksum="3720053559D5D8CC" modified="2014-10-01" version="1">MARAGSRYRLPGERLYNSSWSGIEKSKWDAASQVTRYTRKVASRPAAEADLTEYVNDAPVEFEMRYKIPVESLSPAALAIPERHASYFHVAKHAKQPYDPFFPKTLHPAQFIESSENLTQNYFKILHIDEPEHQVLLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEZ1</accession>
    <name>A0A075AEZ1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169077.1">
        <property type="nucleotide sequence ID" value="XM_009170813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEZ1"/>
    <dbReference type="GeneID" id="20319922"/>
    <dbReference type="KEGG" id="ovi:T265_05740"/>
    <dbReference type="CTD" id="20319922"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="124" mass="14233" checksum="5E7109C10E04074F" modified="2014-10-01" version="1">MELQHVESARNPKPQTWFRDFCGADFSGMRIFLEQVTLGPAPVEERYRITVQKVPRRPMLLNHASLVTKQVADMSSIGAKSDWSKITTLQPIMFKYYKMPAHSTELHGSTISLFMTMRPMSTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFT0</accession>
    <name>A0A075AFT0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168200.1">
        <property type="nucleotide sequence ID" value="XM_009169936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFT0"/>
    <dbReference type="GeneID" id="20319218"/>
    <dbReference type="KEGG" id="ovi:T265_05036"/>
    <dbReference type="CTD" id="20319218"/>
    <dbReference type="OrthoDB" id="6263405at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44854" checksum="563FD1D74B0DF0DE" modified="2014-10-01" version="1">MGDYDSQVDEELFRRILQIVHKDASGELHKLLTELAATHEHGTNGSKLISEDTFFVPFAKRNLLHVATYNQARKCVRLLVNPPHCWDPDKLDGRNHNPMYSAELRDDIGVLVEIARQSKERRDIRSPSVDKPIYGGFPSTALVWPQDLWVHPLRRDAVIGVRHVGISGSEHDATGHYMFRTQMIGPLVALVFELYIANPSLFAFEFWTGEESDNKQRLFWPVPSNEPDLKEEVIEHSSCEEYPHCLYRISVITRQLHLPDQERFVILRNRWVTHTLTSLETSSKSLSMSPPSLMRNCRSVVRRLLINRCIERNVQLNYVQLVRSLRQPQAIEQFLLYQDIWDVPDWEQYLTDGEGANMPYGIRLLTKRIALDTGETGTLIGHRFIPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG07</accession>
    <name>A0A075AG07_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596703">
        <property type="protein sequence ID" value="KER28259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167980.1">
        <property type="nucleotide sequence ID" value="XM_009169716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG07"/>
    <dbReference type="STRING" id="6198.A0A075AG07"/>
    <dbReference type="GeneID" id="20319044"/>
    <dbReference type="KEGG" id="ovi:T265_04862"/>
    <dbReference type="CTD" id="20319044"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="729" mass="79874" checksum="1E46BE5FAE345CF0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGX8</accession>
    <name>A0A075AGX8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167107.1">
        <property type="nucleotide sequence ID" value="XM_009168843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGX8"/>
    <dbReference type="STRING" id="6198.A0A075AGX8"/>
    <dbReference type="GeneID" id="20318359"/>
    <dbReference type="KEGG" id="ovi:T265_04173"/>
    <dbReference type="CTD" id="20318359"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="17498" checksum="64EF903C220ECDD7" modified="2014-10-01" version="1">MQQAGFRPGRGCIDQIFTLRQVLEQRHTYKRPTILVFLDFRGAFDSVDRSVLLETLAHQGMPRNKFMRTFEMISQHHLLTIPQYVVRRSKRIKQFWTEDEHGKPLGRLTTVTIKIEEPCEYVLATRSVPTPSALRISYAVERPLETVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI34</accession>
    <name>A0A075AI34_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596653">
        <property type="protein sequence ID" value="KER30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165328.1">
        <property type="nucleotide sequence ID" value="XM_009167064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI34"/>
    <dbReference type="STRING" id="6198.A0A075AI34"/>
    <dbReference type="GeneID" id="20316937"/>
    <dbReference type="KEGG" id="ovi:T265_02749"/>
    <dbReference type="CTD" id="20316937"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="549"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="746" mass="83079" checksum="EBF7639971C6A4D4" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI64</accession>
    <name>A0A075AI64_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165212.1">
        <property type="nucleotide sequence ID" value="XM_009166948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI64"/>
    <dbReference type="GeneID" id="20316838"/>
    <dbReference type="KEGG" id="ovi:T265_02650"/>
    <dbReference type="CTD" id="20316838"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="288"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="902" mass="96058" checksum="E1DFFCFDF71C9349" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIN2</accession>
    <name>A0A075AIN2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596639">
        <property type="protein sequence ID" value="KER31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164256.1">
        <property type="nucleotide sequence ID" value="XM_009165992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIN2"/>
    <dbReference type="GeneID" id="20316054"/>
    <dbReference type="KEGG" id="ovi:T265_01866"/>
    <dbReference type="CTD" id="20316054"/>
    <dbReference type="OrthoDB" id="6279772at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13244" checksum="7472C5FB4DF50A4F" modified="2014-10-01" version="1">MTFRDPPRTSRLFHITDRSSGLRFLVDTGAEVTTPYIFNAKPDRYSPRGMSQLDYISQFTTDVRYTPGSDIVVVDALSRHDINDLRPSTQLDLAKLANLQNSKRQPLNDKNETDPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIR7</accession>
    <name>A0A075AIR7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164080.1">
        <property type="nucleotide sequence ID" value="XM_009165816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIR7"/>
    <dbReference type="GeneID" id="20315914"/>
    <dbReference type="KEGG" id="ovi:T265_01726"/>
    <dbReference type="CTD" id="20315914"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10599" checksum="9E76C0E2A87461D8" modified="2014-10-01" version="1">MNDIGGENTPLQPRENCPIISANWITVACSHVLEARTGAVVNERANTAYCEHASELEAEEVCTPMGWNHLLRRTRSNRTFNDQTDVYTKLRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIY0</accession>
    <name>A0A075AIY0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163845.1">
        <property type="nucleotide sequence ID" value="XM_009165581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIY0"/>
    <dbReference type="GeneID" id="20326971"/>
    <dbReference type="KEGG" id="ovi:T265_12803"/>
    <dbReference type="CTD" id="20326971"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10447" checksum="87BA33201C79F479" modified="2014-10-01" version="1" fragment="single">MALDSDTSAILFDPHNLPSVRGQKPNPKASVLGWKCKHITIFTERVAIHVPTPNLEGRQSVCQTSNHGLTWYERLCGDARIPSGIAKWVAKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJG6</accession>
    <name>A0A075AJG6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_00836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
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                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
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                <person name="Maleewong W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="135" mass="15569" checksum="530F11AE76A35D2B" modified="2014-10-01" version="1" fragment="single">VAYVVNRRFKLPLSWTFSSRLLLYTGISLFALLCQWQVMLAWRRHNCLRVDEIVAGLNESFLRGGVAYYNWRLRLNQFYHEQILRHRSAALSSKKTESTVDVLTAYQDEQRRAGLLKQDNAEVGETAPDASSSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU31</accession>
    <name>A0A074YU31_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Parvovirus non-structural protein 1 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603774">
        <property type="protein sequence ID" value="KER18311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177942.1">
        <property type="nucleotide sequence ID" value="XM_009179678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU31"/>
    <dbReference type="GeneID" id="20330310"/>
    <dbReference type="KEGG" id="ovi:T265_16145"/>
    <dbReference type="CTD" id="20330310"/>
    <dbReference type="OrthoDB" id="8300295at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Parvovirus non-structural protein 1 helicase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="198" mass="22940" checksum="B550218242E99ACA" modified="2014-10-01" version="1" fragment="single">MRELVRSYDARSFNELYKRLSVQDTDDIYAEYGPTWKETAEHSIANYCKEIILEQETMTFEQILRSNHHSRTCQHPADTLAGEEWLDELIRVNNINKRDLLVALTAVMNKLCTRKNAFVIEGPTTTGKTLFVKLVAENYVYGTVQRSGDHSQFFLMNLLNKTLALMEEPRITQLTVNDFKELLGGNPFDIHVKHQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXM9</accession>
    <name>A0A074YXM9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597213">
        <property type="protein sequence ID" value="KER19423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176828.1">
        <property type="nucleotide sequence ID" value="XM_009178564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXM9"/>
    <dbReference type="GeneID" id="20329707"/>
    <dbReference type="KEGG" id="ovi:T265_15542"/>
    <dbReference type="CTD" id="20329707"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21761" checksum="2CAB0B4C68EC1989" modified="2014-10-01" version="1" fragment="single">MSETTEVCESIADARTTAWSWPEEAPHVSGNPTQPKSIKICTTPGTNSNPMLLREKRSTHFQSTFIQLSPTRITLNVSQSQADRGLKILIQTMGQAFSSSIDLVHKETDLPRHKNITAINRLYKKQNNARNRCLGCAKAECTFNPNVQTFEAATNFTGYLRTTEVQFRNAQAKLEIGSSKPKFPTLFTNYFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0E0</accession>
    <name>A0A074Z0E0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597446">
        <property type="protein sequence ID" value="KER18942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177309.1">
        <property type="nucleotide sequence ID" value="XM_009179045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0E0"/>
    <dbReference type="GeneID" id="20326256"/>
    <dbReference type="KEGG" id="ovi:T265_12088"/>
    <dbReference type="CTD" id="20326256"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20611" checksum="930865B1C32CD0B9" modified="2014-10-01" version="1">MSSASSYPCGVCKFFLIVQCFNEGFTPFVFRFIRFSVLSSSLAPIRSLLTWTGFRPFARLTYGVYLVHPLIILFLCLGGQYPIILDNLFLVSCRRQSALWLPLAGSADQIKFDTVVTPFRCLTAMQPGGSTRAEILPGCSSLNRGSREAVISLFLAVFTLSYGFAYLLSMMTESPTLACEKLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Y2</accession>
    <name>A0A074Z0Y2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_10874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597038">
        <property type="protein sequence ID" value="KER20618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175632.1">
        <property type="nucleotide sequence ID" value="XM_009177368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Y2"/>
    <dbReference type="STRING" id="6198.A0A074Z0Y2"/>
    <dbReference type="GeneID" id="20325042"/>
    <dbReference type="KEGG" id="ovi:T265_10874"/>
    <dbReference type="CTD" id="20325042"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039647">
        <property type="entry name" value="EF_hand_pair_protein_CML-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10891">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER20618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="209" mass="23739" checksum="44D5AD17EC5A4753" modified="2014-10-01" version="1">MPPLGCTSCGLKRLFTMLDTDGDNKITFDELKNGLHMFGFTDDKVKINSTLIKMGLSPMMNTKILEKDKRTQILLQLFEKLDVNHDGKISQEEWDKGMKSMKIDEEYSSKLRNYLDVSCDGVITKQEFMVGLGMVEDPIDWKKVFEALDKDKSGDISVEELKAVFDALEIPILSSGIVEWIAQYDTNKDGKLDYSEFLAFAKVQQSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0Z6</accession>
    <name>A0A074Z0Z6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597030">
        <property type="protein sequence ID" value="KER20691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175565.1">
        <property type="nucleotide sequence ID" value="XM_009177301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0Z6"/>
    <dbReference type="GeneID" id="20324990"/>
    <dbReference type="KEGG" id="ovi:T265_10822"/>
    <dbReference type="CTD" id="20324990"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="16555" checksum="D17EFFEC009C5365" modified="2014-10-01" version="1">MAHSCICGPCRAGFLQVHPDSEKKESTMPDTLVLSVFDGDEAGSKKFHETIGLIQCRYNETRTKIAGLQCWRDYTLELNSGLDKWDSEVHFVYPSKILQYEGPQHQSKPEPAADIADWEIPQWQWYLQELNEKLFNKEDNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z213</accession>
    <name>A0A074Z213_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="19">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_10500</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="19"/>
    <dbReference type="EMBL" id="KL596995">
        <property type="protein sequence ID" value="KER21086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175152.1">
        <property type="nucleotide sequence ID" value="XM_009176888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z213"/>
    <dbReference type="STRING" id="6198.A0A074Z213"/>
    <dbReference type="GeneID" id="20324668"/>
    <dbReference type="KEGG" id="ovi:T265_10500"/>
    <dbReference type="CTD" id="20324668"/>
    <dbReference type="OrthoDB" id="6231256at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097723">
        <property type="term" value="P:amoeboid sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018991">
        <property type="term" value="P:egg-laying behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007060">
        <property type="term" value="P:male meiosis chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031272">
        <property type="term" value="P:regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="20">
        <location>
            <begin position="704"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KER21086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="931" mass="105173" checksum="CBF9D514CAFF9E48" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2Q2</accession>
    <name>A0A074Z2Q2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_15136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596981">
        <property type="protein sequence ID" value="KER21243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175005.1">
        <property type="nucleotide sequence ID" value="XM_009176741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2Q2"/>
    <dbReference type="STRING" id="6198.A0A074Z2Q2"/>
    <dbReference type="GeneID" id="20329301"/>
    <dbReference type="KEGG" id="ovi:T265_15136"/>
    <dbReference type="CTD" id="20329301"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER21243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="779" mass="86441" checksum="4776B646EFF769B1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2S5</accession>
    <name>A0A074Z2S5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596979">
        <property type="protein sequence ID" value="KER21278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174974.1">
        <property type="nucleotide sequence ID" value="XM_009176710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2S5"/>
    <dbReference type="STRING" id="6198.A0A074Z2S5"/>
    <dbReference type="GeneID" id="20329295"/>
    <dbReference type="KEGG" id="ovi:T265_15130"/>
    <dbReference type="CTD" id="20329295"/>
    <dbReference type="OrthoDB" id="6479200at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029168">
        <property type="entry name" value="REC114L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34921:SF1">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15165">
        <property type="entry name" value="REC114-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="27569" checksum="92416AD95131AA59" modified="2014-10-01" version="1" fragment="single">ARNRFPWLDTTKETQPLATSTQLGFVEGQSFTQPLRDEDAQLYVTREWQLERYSRLHPRNSEDGERMDTADGEDSNHEDEWETWEGGSAPALVVRLAGFGHLCIMYGTELVESYFLILAKRWMKAVLVDDEVMIMAKKIAKTARLRLSFRNSDDSKNFFAALGRFAKCKENGSPTAQADPVSERVEDTLSTPAPLPQTWNTEWPTESLEGLVRLCLSDPNFPGFVRRVDSIMKKLTSKGTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2T3</accession>
    <name>A0A074Z2T3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596971">
        <property type="protein sequence ID" value="KER21376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174869.1">
        <property type="nucleotide sequence ID" value="XM_009176605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2T3"/>
    <dbReference type="GeneID" id="20324448"/>
    <dbReference type="KEGG" id="ovi:T265_10280"/>
    <dbReference type="CTD" id="20324448"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9489" checksum="87B0296C67B6C159" modified="2014-10-01" version="1">MGNVQVGHRHTLNAQRRDGQIDGHICRGARTNRLALFGLTKDLKSQKYARFLASMDMDEIAGQQAWWTQILKFAFTNSQSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z364</accession>
    <name>A0A074Z364_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596967">
        <property type="protein sequence ID" value="KER21448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174817.1">
        <property type="nucleotide sequence ID" value="XM_009176553.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z364"/>
    <dbReference type="GeneID" id="20324405"/>
    <dbReference type="KEGG" id="ovi:T265_10237"/>
    <dbReference type="CTD" id="20324405"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1397" mass="152705" checksum="C9A04276C945B08D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3F1</accession>
    <name>A0A074Z3F1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597100">
        <property type="protein sequence ID" value="KER20047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176200.1">
        <property type="nucleotide sequence ID" value="XM_009177936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3F1"/>
    <dbReference type="GeneID" id="20325478"/>
    <dbReference type="KEGG" id="ovi:T265_11310"/>
    <dbReference type="CTD" id="20325478"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13917" checksum="0BCF3F4C4B1DF881" modified="2014-10-01" version="1">MPLEGSTRVRILPGCPSLDSWSRNAEVGFEARTCRWTGKGLCASLSHSFRGAHSPRHSNHTIWIESDNKNATDIGWQPHLVVSPTRHSEDHTAPSSTNNTQAFSDLSYSSAKSSVGHLSVYATLNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3M8</accession>
    <name>A0A074Z3M8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596951">
        <property type="protein sequence ID" value="KER21651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174601.1">
        <property type="nucleotide sequence ID" value="XM_009176337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3M8"/>
    <dbReference type="GeneID" id="20324239"/>
    <dbReference type="KEGG" id="ovi:T265_10071"/>
    <dbReference type="CTD" id="20324239"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="74" mass="8160" checksum="6EFF612298414A98" modified="2014-10-01" version="1">MSTDERGYFRATRPMELIPVSEIEYERKPKLYLPLTTATPPFVATISVLTNAKKCAQSTSSSDPHVCGNAAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3U9</accession>
    <name>A0A074Z3U9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596945">
        <property type="protein sequence ID" value="KER21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174529.1">
        <property type="nucleotide sequence ID" value="XM_009176265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3U9"/>
    <dbReference type="STRING" id="6198.A0A074Z3U9"/>
    <dbReference type="GeneID" id="20324187"/>
    <dbReference type="KEGG" id="ovi:T265_10019"/>
    <dbReference type="CTD" id="20324187"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25958" checksum="045922B190919C7A" modified="2014-10-01" version="1">MTAGFPPDYMHISLALSVDFPRKCRGVVDLDRWKASELRQLLLYTGPVVLRDILHPNVNECFILFTFFPQHYADFLVDASKVFVSKFAAIFGPSHIGYNVYLFSHLFNLIELYRCLDRFSCFSYEPELGHLKHYIHGPKLPAVLLYRRLNERVGLDAVERKIFLDDVGLPLPDATGLFIGMSFFRKSFPTTAFCLMISQMSLRIFLEILLSTRNSKLLSHFTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4D5</accession>
    <name>A0A074Z4D5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_09830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596928">
        <property type="protein sequence ID" value="KER21956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174280.1">
        <property type="nucleotide sequence ID" value="XM_009176016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4D5"/>
    <dbReference type="STRING" id="6198.A0A074Z4D5"/>
    <dbReference type="GeneID" id="20323998"/>
    <dbReference type="KEGG" id="ovi:T265_09830"/>
    <dbReference type="CTD" id="20323998"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER21956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60386" checksum="A391C35C2D63A56D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z558</accession>
    <name>A0A074Z558_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596913">
        <property type="protein sequence ID" value="KER22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174064.1">
        <property type="nucleotide sequence ID" value="XM_009175800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z558"/>
    <dbReference type="STRING" id="6198.A0A074Z558"/>
    <dbReference type="GeneID" id="20329089"/>
    <dbReference type="KEGG" id="ovi:T265_14923"/>
    <dbReference type="CTD" id="20329089"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="315"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="511" mass="57297" checksum="52336DFB53FE5037" modified="2014-10-01" version="1">MHFHFAQQVFYNLFKHIRKTNLITLAISCISIVFLLVIKLFIEPQLQRCGHCKFPIPSELMLVAIGTVVSHFVELQDNHNVTIVGSISSGMPPISVPQWNLMSPMVTDAIIIGFTSTFLTISLVKLFAMKYKQDIDYNHELTSLGVISLIASFFSSIAPSSSVSRSMVLEGAGVKTTLSGIPSGLLVIFVLLFLGPYFSVTPTCVLSAIIVVALKNIIAHLSHTPKLWRTYKRDFFLFMITFVVTLVLDVTIGLVVGVVACLLALTEQQRALTITLLDNLPGTELFLHGRAKLATGELHSTKFLYPLTRSIISCRLIGSLNFASSEQLESKITKVLKEHESRLGSLEDFEYAVNPSNTVSADPILETQQKHQQRQKQQNTADKRLSAAEEAYRRFSSNLDRIEMSQDKTEKFYLEIHDKKEYAPQRFLLIDISGMTDVDPSGALCLSTVHEQFYSIGVILVYIGDLSQFRCLDTSKWERFPSLSLSYPTMYDGYLACQHALFESMVTLHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z563</accession>
    <name>A0A074Z563_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596912">
        <property type="protein sequence ID" value="KER22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174050.1">
        <property type="nucleotide sequence ID" value="XM_009175786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z563"/>
    <dbReference type="STRING" id="6198.A0A074Z563"/>
    <dbReference type="GeneID" id="20329084"/>
    <dbReference type="KEGG" id="ovi:T265_14918"/>
    <dbReference type="CTD" id="20329084"/>
    <dbReference type="OrthoDB" id="6279736at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31427" checksum="DC857BAAC90E706C" modified="2014-10-01" version="1" fragment="single">PIGIASIVIGVILFVIAILGFVGICCHVKAVLIVVSLVGVICWIEFTCVDALVMEARKKFKLTIDVTGMNKCLYACIVGLIALAHFILIIIHFSDEDRCLRRISRNIHYLVKGYKSIESGEIFSVTFGMIMTMAQSPGFHQTYVLLEPKLDYFREIHSFANQFDFAIDSPGTQATEYASPDRLPFQLLRYSRYRDKCAFLIVQHIQLTGNITDKRFGSVSAIQFPAPCCKKGYVGEGAQNCPQMFTELNSNYLRGCNEVLYYSLKKPITITALASLVIPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z590</accession>
    <name>A0A074Z590_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_15262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597032">
        <property type="protein sequence ID" value="KER20677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175580.1">
        <property type="nucleotide sequence ID" value="XM_009177316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z590"/>
    <dbReference type="STRING" id="6198.A0A074Z590"/>
    <dbReference type="GeneID" id="20329427"/>
    <dbReference type="KEGG" id="ovi:T265_15262"/>
    <dbReference type="CTD" id="20329427"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER20677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="431" mass="46776" checksum="3F12C1E5C5133CFD" modified="2014-10-01" version="1" fragment="single">GKLIPRIDLKHIGAASVLGRREKNEDRLLACQLSPNHLLFGVFDGHGGSAAAEFARSVLPECIRYGLAALQNTVRKRGQSLRTTDLALFEPVMEHAFLQVNNLMMRHFYHYATARERLWAGTTATVVLLLNSHQVVVGHVGDSRALFSRHGSITALTTNHDPNSTVLLNDICKDDDGRGMTEVARIKKCGGQVITNSLGVPVVNGRLGMTRSLGDSQLKPFGVTAKPQLTSMKVRHGSASFLALVSDGVTYVMSDEEIQSTIASCRTPRDAAECVVENALLFGSDDNASALVIPFGSWAFIMSANEDDQLPVYPLNECGEQLAEQLNARGLKCQFVVCAPGRVNLIGEHIDYNGYAVLPMALEQAIHLAVATWPTKSVILSSSDANYEPATVSIEEALTFGSDGPPVAVQWFHYPLCAYHGIADYVKQNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5M6</accession>
    <name>A0A074Z5M6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caspase domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596899">
        <property type="protein sequence ID" value="KER22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173826.1">
        <property type="nucleotide sequence ID" value="XM_009175562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5M6"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20323651"/>
    <dbReference type="KEGG" id="ovi:T265_09482"/>
    <dbReference type="CTD" id="20323651"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39802" checksum="48FAAC8F9CA99A6D" modified="2014-10-01" version="1">MRKNKVPPENIITFAHDDIANNPKNPFKGKVFHDYELEDVYKGVLIDYRGKDVTKDNFLKVLEADNKLEANKKKVLKSGPDDNVFIFYSGHGGKSFVTFPEADLTAMELDDTLAYMHSDKMYNKLVLYVDACYSGSMFKDVLPSNMGIYATTSANEEEQSWSLFCYDKRFGVCLANEYSYAWITDSEYNDLKKRTVEQQYQEVKKRTALSHAMKYGEMPIAVDRKPSFSAHLFPKFRRFMGAETDGEHETAWRKLHRAIQLRHIVKETFRDIVIDVTTQHMPTIKGLSKRDELVCFKAVFDQFRTHCFTIQQVPDVAHHISHLMELCKAGYGTETLIDSVYLVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z898</accession>
    <name>A0A074Z898_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 6">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_09967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 6"/>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174468.1">
        <property type="nucleotide sequence ID" value="XM_009176204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z898"/>
    <dbReference type="STRING" id="6198.A0A074Z898"/>
    <dbReference type="GeneID" id="20324135"/>
    <dbReference type="KEGG" id="ovi:T265_09967"/>
    <dbReference type="CTD" id="20324135"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="270" mass="30909" checksum="A2C2B6445C12904F" modified="2014-10-01" version="1">MDPDEKNRLLAHSIKFMKKVVNAAGLTAVSRNFNRYEDFKRLFKGRKRFTNYSKTLQAIVAGKKILRQRMKNALQAMPQELIASKSQRLTEQLLSSPEYQISRNMGIYLSLPKEPNTEKIIQQALAGGRKIFVPQLLSQEYQSVNNLQGNASGMCMRRLSSITQMEQWPLNRWNIREPPPPTGWDQIADQSVEEGGLDLLIVPGLAFTRLGDRLGRGGGYYDRYLSWYRIKSRSSHLHYPVLLSLTFEEQIVDELPVEPHDIKVDCVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8V1</accession>
    <name>A0A074Z8V1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596844">
        <property type="protein sequence ID" value="KER23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172662.1">
        <property type="nucleotide sequence ID" value="XM_009174398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8V1"/>
    <dbReference type="STRING" id="6198.A0A074Z8V1"/>
    <dbReference type="GeneID" id="20322732"/>
    <dbReference type="KEGG" id="ovi:T265_08553"/>
    <dbReference type="CTD" id="20322732"/>
    <dbReference type="OrthoDB" id="10066543at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="215"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="395" mass="44287" checksum="9F51AC62D2F2ADE8" modified="2014-10-01" version="1">MVRPAAQLEHNHTSPPFASARLFKDAFVSFVKREECRERNRQTGHWILAQACPLTSSGLALNIVIPFSSITPSVPNFQETRRKHEGRDTTKLLEPRQGELGSRGWTRTKNFPVSKFVPHSPNHIDLRRPTNDEQCLLIKKCRARKEALLSGVIRVSEHRQARNCLIKMVQSSHFAQELHQVNASVLDAKRSSLRKLSPVLIGGILCVGGRLITALIIRRLHEVEGHCGTGQVLDSTRLRYWIINGTGAVKRVIGVCSLCRRRSAQIGTQMMAPLPADRVGVGWGPFECSVWKWQATCRRSVGRRGKSTDIYSDNGRNFVGALTEFWDDTKRWSQRHQYLDIIAKKSFSCNTLPVLPEGTTRTGILPGCPSLDRGSREVEVGLEARIVNSVSKFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z921</accession>
    <name>A0A074Z921_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172575.1">
        <property type="nucleotide sequence ID" value="XM_009174311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z921"/>
    <dbReference type="GeneID" id="20322676"/>
    <dbReference type="KEGG" id="ovi:T265_08497"/>
    <dbReference type="CTD" id="20322676"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14414" checksum="894D7D6C97172D15" modified="2014-10-01" version="1">MCCTRPPYVSVATMFEISRYIVRTLACSDVVINLLRKFEPRHGYALLMSSSRSETRVQCSICLLWEHQNNCSRTRGQLFKHIRFKGHTADDTSRLETVVNRDGTRRMKQNVRPSSAEGLLDGDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9V6</accession>
    <name>A0A074Z9V6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597103">
        <property type="protein sequence ID" value="KER20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176221.1">
        <property type="nucleotide sequence ID" value="XM_009177957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9V6"/>
    <dbReference type="GeneID" id="20325497"/>
    <dbReference type="KEGG" id="ovi:T265_11329"/>
    <dbReference type="CTD" id="20325497"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10108" checksum="30E9838AFDB16317" modified="2014-10-01" version="1">MAEVHAGIAAEAGGSDRLSPPEELMKPGEEEEEEGDVKCEKEVEEDSLALYIQNEIGSELFEAPHTANIISVGLKDYGDSNRADRFLIEHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9X2</accession>
    <name>A0A074Z9X2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597101">
        <property type="protein sequence ID" value="KER20040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176211.1">
        <property type="nucleotide sequence ID" value="XM_009177947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9X2"/>
    <dbReference type="GeneID" id="20325490"/>
    <dbReference type="KEGG" id="ovi:T265_11322"/>
    <dbReference type="CTD" id="20325490"/>
    <dbReference type="OrthoDB" id="1906921at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="599" mass="66488" checksum="72E6889E264947F3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB42</accession>
    <name>A0A074ZB42_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_11013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597057">
        <property type="protein sequence ID" value="KER20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175813.1">
        <property type="nucleotide sequence ID" value="XM_009177549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB42"/>
    <dbReference type="STRING" id="6198.A0A074ZB42"/>
    <dbReference type="GeneID" id="20325181"/>
    <dbReference type="KEGG" id="ovi:T265_11013"/>
    <dbReference type="CTD" id="20325181"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dwarfin"/>
    </dbReference>
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        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="495"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="658"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="790" mass="84676" checksum="94FA49ED62D2906E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB90</accession>
    <name>A0A074ZB90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596877">
        <property type="protein sequence ID" value="KER22842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173415.1">
        <property type="nucleotide sequence ID" value="XM_009175151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB90"/>
    <dbReference type="GeneID" id="20323328"/>
    <dbReference type="KEGG" id="ovi:T265_09149"/>
    <dbReference type="CTD" id="20323328"/>
    <dbReference type="OrthoDB" id="6240020at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER22842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17979" checksum="EDA627ABEFEBF6A1" modified="2014-10-01" version="1">MKAFLKQALSLCNIHMSSPMGGETRQTKEDRSKISFSPVIRTEQKALLLNRRSGQLKRLRNARYQRITRSKQSWKLVNNKPRHKSKEQTSSPRVTMRTQEAAPQLLSLAKQIVRTRNSLFGGTTRRAFTKKEPKSILFADETFRHHGKTVKDIVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBH2</accession>
    <name>A0A074ZBH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597041">
        <property type="protein sequence ID" value="KER20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175668.1">
        <property type="nucleotide sequence ID" value="XM_009177404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBH2"/>
    <dbReference type="GeneID" id="20329454"/>
    <dbReference type="KEGG" id="ovi:T265_15289"/>
    <dbReference type="CTD" id="20329454"/>
    <dbReference type="OrthoDB" id="6270619at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="189" mass="21061" checksum="CEE01BDA169143D9" modified="2014-10-01" version="1" fragment="single">MDCSIGYLTMLESQITAAKLGTPQHERYTNFILPKPPCDLDFDGTVRTLSQIFGNQSSPFIIRYQCLKVIKKDEDLITFAGVVSRKCERFKLSSMTENKLKCPISASGLQLPRDAGIKTRMLSGIGQDAEMTMQSFTTDCQCLVNLKHDTVMIGHPRVALCSSAQTFKSTTPKKYGNMPEQAFHKLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBU7</accession>
    <name>A0A074ZBU7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="KL596866">
        <property type="protein sequence ID" value="KER23077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173187.1">
        <property type="nucleotide sequence ID" value="XM_009174923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBU7"/>
    <dbReference type="STRING" id="6198.A0A074ZBU7"/>
    <dbReference type="GeneID" id="20323155"/>
    <dbReference type="KEGG" id="ovi:T265_08976"/>
    <dbReference type="CTD" id="20323155"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER23077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="330" mass="37732" checksum="97290C1B08010A49" modified="2014-10-01" version="1">MWERLASAVLPPHPDPRTDAYPLMGSWPPTALISLAYVVGVYAWRNELLKKRCKVQQKGTNSSTAAATKDMQTNSWGFVKCLMVLYNFIMVLYSAYMVIGTLGTVSKLGYGLGCETQPDPNDRQTDSLLYFGYLFYFSKFVEMLDTVFFLWRGKVDQVTFLHVFHHATMPPSIWWGIRYAPGGIVYTFLVANSFIHVIMYTYYGMAAAGLYKYLWWKNYLTIAQMIQFVFLIVHQSQIFIRSTPCNYPKVFPAAIIFYASVFLVLFGNFYVQAYWRKQRLAKRIQRATAAAECTNGTKPMANGHVMQNGTVTSNGYVPNGDQARARKRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC18</accession>
    <name>A0A074ZC18_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597025">
        <property type="protein sequence ID" value="KER20745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175497.1">
        <property type="nucleotide sequence ID" value="XM_009177233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC18"/>
    <dbReference type="GeneID" id="20324934"/>
    <dbReference type="KEGG" id="ovi:T265_10766"/>
    <dbReference type="CTD" id="20324934"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="130" mass="14504" checksum="2F32BAB27B0D7D56" modified="2014-10-01" version="1">MAPRKQSDDYLSARWPSGGQTETRYTEKGPVIAQSATTALKDSTAYENTLYDHRHLALSPTRDTIIHTEMSRLVKTATKTDIYGKRNYPATTKLCFGNFSKGERDKSDTTSEKDSATRNQGEHVDSTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCG3</accession>
    <name>A0A074ZCG3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171415.1">
        <property type="nucleotide sequence ID" value="XM_009173151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCG3"/>
    <dbReference type="STRING" id="6198.A0A074ZCG3"/>
    <dbReference type="GeneID" id="20328492"/>
    <dbReference type="KEGG" id="ovi:T265_14326"/>
    <dbReference type="CTD" id="20328492"/>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="19880" checksum="CA37FB7AFA079697" modified="2014-10-01" version="1" fragment="single">VSKDYSDAVIQNTFQIHHIASFVEGEQTLKPEDVVRHSTALQESKKIEEVSCAVKMDARGMRVKLEKTKETVESFEWSGVKNQAAILNPLDNFDFKYLVFFRLVQLKDRINELHVFSCDTPSSAKSFVDSISYYKKNARRRSLSESRISFDGSTLRKDNSGRPDEVGNPISVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDU8</accession>
    <name>A0A074ZDU8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_14563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KL596834">
        <property type="protein sequence ID" value="KER23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172460.1">
        <property type="nucleotide sequence ID" value="XM_009174196.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZDU8"/>
    <dbReference type="GeneID" id="20328729"/>
    <dbReference type="KEGG" id="ovi:T265_14563"/>
    <dbReference type="CTD" id="20328729"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF66">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE TAILOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="1470"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1546"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1645"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1767"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1669"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1777"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1835" mass="205724" checksum="92960F283B1C6FA0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG08</accession>
    <name>A0A074ZG08_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596753">
        <property type="protein sequence ID" value="KER26201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170022.1">
        <property type="nucleotide sequence ID" value="XM_009171758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG08"/>
    <dbReference type="STRING" id="6198.A0A074ZG08"/>
    <dbReference type="GeneID" id="20320663"/>
    <dbReference type="KEGG" id="ovi:T265_06484"/>
    <dbReference type="CTD" id="20320663"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22114" checksum="68CE96A3E831A9FB" modified="2014-10-01" version="1">MYTCGSELVVESVADLRDLGSVKRVIKTAIMSKQVELADFLSELITKACISILPHKSHFNVDNVRVLKILVSTESLVFVGDFADLLTGRSVVRTRPLPPNFPCLGLGNLTVSQPSCFLPVTWQLGTKRVLQLNDFDFFVFKAWWFVGSGNRICPIDIKHSGLSYTFHVEARCELLRAIRSRTIRKRMFGHTTRTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGD8</accession>
    <name>A0A074ZGD8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169913.1">
        <property type="nucleotide sequence ID" value="XM_009171649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGD8"/>
    <dbReference type="GeneID" id="20320580"/>
    <dbReference type="KEGG" id="ovi:T265_06401"/>
    <dbReference type="CTD" id="20320580"/>
    <dbReference type="OrthoDB" id="10301415at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="37378" checksum="22C5A8157941D708" modified="2014-10-01" version="1">MGHRIDLENVEVLRRGLRFTPHRLTAEAVEITRHYSVNRMEGAELPTVWKAVLRISGSRVKEAVETELVEIDDALHNPVATFYVYYEADPGTKLQHHPKEFNLHAETTIEVRFRFPVPPNMTVDASKSSQAKALSDMMTKELNRNFDMNQVVESTVLEGFEFTGSPVMFRGMVNFNLYKLQKRFIQFDWTNPVNTFNLYMRNQIPFFMKGSVTTASVGKKDTSAQVGRLNPEEAQLGGRFGVDTQRSDSGKRLLQCLFLVSTNLQHERSNRVTYRPPATRRFWTQLDHVTINYRWNRQLKIVVPSGMLKSTLITPDYHSALRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGK3</accession>
    <name>A0A074ZGK3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596902">
        <property type="protein sequence ID" value="KER22380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173878.1">
        <property type="nucleotide sequence ID" value="XM_009175614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGK3"/>
    <dbReference type="GeneID" id="20323689"/>
    <dbReference type="KEGG" id="ovi:T265_09520"/>
    <dbReference type="CTD" id="20323689"/>
    <dbReference type="OrthoDB" id="6244958at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="24376" checksum="60A2A0D312D46BC7" modified="2014-10-01" version="1">MLYCLIRIRRLKCSVQLDLKGSAWPENSEESMGIRRLMPLHAAYTLEAILSSSKDLTFSQYQTPSHSLCTHFFSAPNGNAKSAHQLMLDHINAIGGINYGLLQHFYAGGRKEQRSIRMEKVFRKLRIRAAVRWGITRNYKQASVFVPSSLIELGKRTEQRRLFTGIQSTKARSVLRLSTTPTPYIPRAIASGSPDTRREKCETAEVKQLSSSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGT8</accession>
    <name>A0A074ZGT8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein axonemal light chain 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596898">
        <property type="protein sequence ID" value="KER22455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173815.1">
        <property type="nucleotide sequence ID" value="XM_009175551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGT8"/>
    <dbReference type="STRING" id="6198.A0A074ZGT8"/>
    <dbReference type="GeneID" id="20329023"/>
    <dbReference type="KEGG" id="ovi:T265_14857"/>
    <dbReference type="CTD" id="20329023"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER22455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="239" mass="27018" checksum="FB256AB6B8CC95E3" modified="2014-10-01" version="1">MEEEKEVKEDVVKNAFTYPLVRYSEMNEELQAEVVELCVTACEKWHSDNEMAARMIKEALDQKASSGWHVVIGEGYGFEVTHDVRSLLFMYFNGSLAILIWKGIGARASNPSPSMRSSPTNETCLHLQGLVACSTFPFPGRPAQRKLTFKLHCQIIVCYPLACVHLSHDSSRNSVDWHTWPSQRNLCSTISSSIEVLKRKNLVRSKASLAYVCRTIVCRRECCFPCPIQSDVNKEVTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH99</accession>
    <name>A0A074ZH99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596743">
        <property type="protein sequence ID" value="KER26588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169630.1">
        <property type="nucleotide sequence ID" value="XM_009171366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH99"/>
    <dbReference type="STRING" id="6198.A0A074ZH99"/>
    <dbReference type="GeneID" id="20320347"/>
    <dbReference type="KEGG" id="ovi:T265_06165"/>
    <dbReference type="CTD" id="20320347"/>
    <dbReference type="OrthoDB" id="6278752at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="603" mass="68071" checksum="A950690A5F2DB68F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHK5</accession>
    <name>A0A074ZHK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169541.1">
        <property type="nucleotide sequence ID" value="XM_009171277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHK5"/>
    <dbReference type="STRING" id="6198.A0A074ZHK5"/>
    <dbReference type="GeneID" id="20320281"/>
    <dbReference type="KEGG" id="ovi:T265_06099"/>
    <dbReference type="CTD" id="20320281"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="37891" checksum="41DEC0B99D1B2B23" modified="2014-10-01" version="1">MKTPHRCCVRQKAGGVYIHLVLEAGLVRQLRGIRTRAKNADIQMNVGGILACSISRTQLWPTSSHKTSPFFGQPFVVGIHCVGGRLSERCIRSLKHSTRHLVCIICDSPARAFLKQAKRHTGYHGCDYCTQNGMQVGTRMTFPSLTASVPCDSDLRTRKQNKRRTGPSLITCGVCLGLVRKVLTSLLGMEIGQKARLSLEFWNLLNDTIEQRSVIPSSDFARKCRGVGDLNRWKASELQQFLLHIEPVVLKGILHPDVYKRRMYFAVAGSNFIAILGPNHLVYKLHESSPLFSFVKSYGRLDRFSCLPYETELAHINHSHMGQNRRLFSCTADWPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHL2</accession>
    <name>A0A074ZHL2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171060.1">
        <property type="nucleotide sequence ID" value="XM_009172796.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZHL2"/>
    <dbReference type="GeneID" id="20321488"/>
    <dbReference type="KEGG" id="ovi:T265_07309"/>
    <dbReference type="CTD" id="20321488"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="849" mass="96165" checksum="684B0908C6F1EDB3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHP2</accession>
    <name>A0A074ZHP2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="2 5">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="2 5"/>
    <dbReference type="EMBL" id="KL596738">
        <property type="protein sequence ID" value="KER26788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169455.1">
        <property type="nucleotide sequence ID" value="XM_009171191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHP2"/>
    <dbReference type="STRING" id="6198.A0A074ZHP2"/>
    <dbReference type="GeneID" id="20328090"/>
    <dbReference type="KEGG" id="ovi:T265_13923"/>
    <dbReference type="CTD" id="20328090"/>
    <dbReference type="OrthoDB" id="545675at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="364" mass="41732" checksum="9BE904F2BADFBF25" modified="2014-10-01" version="1">MGRLAQELSDSFYRNVPKYGKITSRLPDCSSRHTYQKCFGQCCIVCCTFMCLGYFVVLRSQPSVVLQDCEVRQREQALVFIGGHPRSGTTLLRIMLDVHPMIRCGPETHVLPALLTMVKKFEKGFQKQRLEAAHLFPDPLYRASSAFVSSLIDAAGSPAPVLCNKDPLTLQHISRLRMMFPKAKFIHIVRDGRAVTNSMIKRKIRMSSVITDPQKLFTRWERIVRDVDQQCSDTDKCFTVLYEDLVLRPNDTMHKLLSFLDVPWDPIVLHHETAMINETLVNTMEPSSTQVVHPIHTEALSSWASNSSKLPRTFIQRVHLDSDMLRKFGYADRGIPPFYGRAEPEIELQTKQLRKDEDFLKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHS9</accession>
    <name>A0A074ZHS9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_14777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596878">
        <property type="protein sequence ID" value="KER22830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173438.1">
        <property type="nucleotide sequence ID" value="XM_009175174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHS9"/>
    <dbReference type="GeneID" id="20328943"/>
    <dbReference type="KEGG" id="ovi:T265_14777"/>
    <dbReference type="CTD" id="20328943"/>
    <dbReference type="OrthoDB" id="6272940at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="330"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="449"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="568"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="681"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER22830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="905" mass="101259" checksum="E17D7621C3751A50" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZI88</accession>
    <name>A0A074ZI88_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596732">
        <property type="protein sequence ID" value="KER27038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169203.1">
        <property type="nucleotide sequence ID" value="XM_009170939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZI88"/>
    <dbReference type="STRING" id="6198.A0A074ZI88"/>
    <dbReference type="GeneID" id="20328038"/>
    <dbReference type="KEGG" id="ovi:T265_13871"/>
    <dbReference type="CTD" id="20328038"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="8">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="542" mass="62236" checksum="00A5D61EF688E59E" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIE9</accession>
    <name>A0A074ZIE9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDA1/CD39 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596772">
        <property type="protein sequence ID" value="KER25572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170657.1">
        <property type="nucleotide sequence ID" value="XM_009172393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIE9"/>
    <dbReference type="STRING" id="6198.A0A074ZIE9"/>
    <dbReference type="GeneID" id="20321155"/>
    <dbReference type="KEGG" id="ovi:T265_06976"/>
    <dbReference type="CTD" id="20321155"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49522" checksum="9D4E6C5A88B3723E" modified="2014-10-01" version="1">MECSAATRRGLIIGATVVIAISAVALIIVAVLYALASNVGLMHAVVLDAGSTSTKLNLYEWVDDPFRTNAQVKQIADSRVRPGISAFVDQPFEAYKKLEEPLKALVANLSEEERKKTPVYLAATAGMRLKLLEDPLGSLDLFDKLRRGLLTSGLSVQVPNERIRLLSGAEEGLFGWITVNNILNLITTDVQVSSDRTVGSLDLGGASTQIAFVPSPVPTTLEKTADMFPLKLFGGQYDVYSHSFLCYGKNEAERRVMGAAIGSSMGSEISHPCLLSGYLSGEMDPDKIFSGPCMSGSYANKVFGKEYTKPPQLTKFKFKGTGNLDTCKDLISKQFKKDNCTIPPCSFNNVFQPPVVGEFRAYAGFSYVAKYLFSSRSTGISKTEFGEKVKEFCTQPWQTIAAKTPPEEQESVAKYCFDGVFVSVLLQNYGFTEDEEWKKITFGDKVSEFEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIK7</accession>
    <name>A0A074ZIK7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_06972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596771">
        <property type="protein sequence ID" value="KER25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170642.1">
        <property type="nucleotide sequence ID" value="XM_009172378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIK7"/>
    <dbReference type="GeneID" id="20321151"/>
    <dbReference type="KEGG" id="ovi:T265_06972"/>
    <dbReference type="CTD" id="20321151"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="574" mass="66124" checksum="56BD5197DBFE2CE6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJJ3</accession>
    <name>A0A074ZJJ3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596721">
        <property type="protein sequence ID" value="KER27518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168752.1">
        <property type="nucleotide sequence ID" value="XM_009170488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJJ3"/>
    <dbReference type="STRING" id="6198.A0A074ZJJ3"/>
    <dbReference type="GeneID" id="20319659"/>
    <dbReference type="KEGG" id="ovi:T265_05477"/>
    <dbReference type="CTD" id="20319659"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF21">
        <property type="entry name" value="PERICARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="845" mass="94520" checksum="FAED1BCCF55064F6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJL3</accession>
    <name>A0A074ZJL3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_14096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KL596760">
        <property type="protein sequence ID" value="KER25982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170282.1">
        <property type="nucleotide sequence ID" value="XM_009172018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJL3"/>
    <dbReference type="STRING" id="6198.A0A074ZJL3"/>
    <dbReference type="GeneID" id="20328262"/>
    <dbReference type="KEGG" id="ovi:T265_14096"/>
    <dbReference type="CTD" id="20328262"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER25982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="319" mass="36089" checksum="5C060A751220F3CC" modified="2014-10-01" version="1" fragment="single">MLLTCFSRNGGLPKRLKNLCQFYSGNTSWARSKHRALQRHANVQGVLPVSGKVIGRCGLFTFVSVSALLFGSTVWSFEHWRARSWRLKHGHDGSGDRLRFSTQVRSKKTRILVRQTLPSKRCILGYVVFGVSLNLVFSILAIVACNLVVFIGHRSPLQSIFLRYFVNSPYGPTPALSMLLSVFSHHSPFHLAINMYVLHSFTSTLINILGPGDFIYLFVGGGAFGEPNYDGIYCSLSQVLQWWWYGRNMETSKHSCLSVAQVAWGMIRMDLALRTNEQLYSSGGVFCQHTQKHLVCYATFLSGFGYSLFFLLQLSEWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJL7</accession>
    <name>A0A074ZJL7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_13772</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168721.1">
        <property type="nucleotide sequence ID" value="XM_009170457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJL7"/>
    <dbReference type="STRING" id="6198.A0A074ZJL7"/>
    <dbReference type="GeneID" id="20327939"/>
    <dbReference type="KEGG" id="ovi:T265_13772"/>
    <dbReference type="CTD" id="20327939"/>
    <dbReference type="OrthoDB" id="411469at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="entry name" value="Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051208">
        <property type="entry name" value="Class-I_Fumarase/Tartrate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389:SF0">
        <property type="entry name" value="FUMARATE HYDRATASE CLASS I, AEROBIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30389">
        <property type="entry name" value="FUMARATE HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="FumA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic" evidence="12">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-S hydro-lyase tartrate dehydratase beta-type catalytic" evidence="13">
        <location>
            <begin position="278"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER27543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="496" mass="54001" checksum="967AD65817D8A31D" modified="2014-10-01" version="1" fragment="single">MVDIAHLLRPSHLESLSNILKDKDASNNDKFVALELLKNANIAAGMVLPGCQDTGTAICMGKKGQYVWTDGRDAEAISRGIYDTYTSTNLRYSQVAPVDMFTEKNTGTNLPAQIELYSTGGNEYNFLFIAKGGGSANKTFLYQQTKALLNPEKLYAFINEKIKTLGTAACPPYHLAVVVGGTSAEMTLKTVKLASCKYLDNLPTCGNEHGRAFRDIDAEARVLELTRKLGIGAQFGGKYFCHDVRVVRLPRHGASCPVGIGVSCSADRQILGRITADGVFLEQLETDPSKYLPDPDTEKLSADVVKVDLNQPMDKVLAVLSKHPIRTRVSLTGTLVVARDAAHAKIKERLDAGEAMPQYMRDHPVYYAGPAKTPVGYASGSFGPTTAGRMDAYVDQFQKAGGSKIMLAKGNRSKQVTEACKKYGGFYLGSIGGPAAILAKNCIKKVEVLEYPELGMEAIWRIEVVDFPAFIVVDDKGPELHSINKLFAHISEKHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKT7</accession>
    <name>A0A074ZKT7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596828">
        <property type="protein sequence ID" value="KER23975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172282.1">
        <property type="nucleotide sequence ID" value="XM_009174018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKT7"/>
    <dbReference type="GeneID" id="20322449"/>
    <dbReference type="KEGG" id="ovi:T265_08270"/>
    <dbReference type="CTD" id="20322449"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="10337" checksum="04D3409BD4CA9EA5" modified="2014-10-01" version="1">MSFQLEYDVDLYSTFIRVQLNSAESPVESKLVGKRIFSTEMRDMTNTHYEQKHNTPPHQTQMGFALFERNPNGLVQRGPTNSSDIAKTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL72</accession>
    <name>A0A074ZL72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_06254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169728.1">
        <property type="nucleotide sequence ID" value="XM_009171464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL72"/>
    <dbReference type="GeneID" id="20320436"/>
    <dbReference type="KEGG" id="ovi:T265_06254"/>
    <dbReference type="CTD" id="20320436"/>
    <dbReference type="OrthoDB" id="9983318at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="452" mass="50425" checksum="8948B6A4238681DA" modified="2014-10-01" version="1">MDQQNSTLFHDLEQSYVMQIGGLCLKIYASLLLLVGIPANIICGIIMGGNRSNRMTTRFLMIVLSIADSAVLLVAVLRYWTMRVLKWDPRLIGPTACKLHTFSVGCSTDYAVGALCALAVERLLVVAFPHKANSIVNMCSVTFGMGGFGLLVVAKNMLIFWLVGSTKPGISDKTNMSLPIRIGTSDCTPLPEYRQIFKIFTKVDLVSFAVLPYIILFSSNLFIYVKLRNQQALLRRAKPKSPLSRLRQSIREEGQHPVRNEPLSSDGKAITNTNRLQSIISRSGTDKRTKRRPDGVIKLLTALTLIHVICTLPGTLFTFITSYPKNLVSIRKDVEELLKSGLVMLVFTNNAINFFGYYASSTAFRESFCGMFRCDWHKSVCQQRLFNHCGCRCVKHKQISGSEFVQLVVTPPGVKVASTRPTERERNVANSQGSLKESPQRIIDAKVDSFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL93</accession>
    <name>A0A074ZL93_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596706">
        <property type="protein sequence ID" value="KER28118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168098.1">
        <property type="nucleotide sequence ID" value="XM_009169834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL93"/>
    <dbReference type="GeneID" id="20319139"/>
    <dbReference type="KEGG" id="ovi:T265_04957"/>
    <dbReference type="CTD" id="20319139"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="6900" checksum="8E974ACD6FF0B5D7" modified="2014-10-01" version="1">MRLPGGEIQSYTKGGQPNSFPSLNGSEAPILRKMQISSNNLSNFAVRFVMLFTPASCKLLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLK7</accession>
    <name>A0A074ZLK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596818">
        <property type="protein sequence ID" value="KER24235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172037.1">
        <property type="nucleotide sequence ID" value="XM_009173773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLK7"/>
    <dbReference type="GeneID" id="20322257"/>
    <dbReference type="KEGG" id="ovi:T265_08078"/>
    <dbReference type="CTD" id="20322257"/>
    <dbReference type="OrthoDB" id="6287771at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13287" checksum="66B42C5D1F21938A" modified="2014-10-01" version="1">MPLAQKPNRKAALFGGKCKCITISTEQVATHVPTPGLEGQETVFVRPLTNLLWETASRSRHTDDGRAIRTKNPTGLAINQRYRCGNFVSSAKKVELIAPTPPFDVKFGQRPIDSQKTPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLQ8</accession>
    <name>A0A074ZLQ8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_13950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169580.1">
        <property type="nucleotide sequence ID" value="XM_009171316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLQ8"/>
    <dbReference type="GeneID" id="20328117"/>
    <dbReference type="KEGG" id="ovi:T265_13950"/>
    <dbReference type="CTD" id="20328117"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="131"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="301"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="409"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="556"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="957" mass="105811" checksum="EB65C1A24E929D35" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM61</accession>
    <name>A0A074ZM61_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167769.1">
        <property type="nucleotide sequence ID" value="XM_009169505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM61"/>
    <dbReference type="STRING" id="6198.A0A074ZM61"/>
    <dbReference type="GeneID" id="20318883"/>
    <dbReference type="KEGG" id="ovi:T265_04701"/>
    <dbReference type="CTD" id="20318883"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="4">
        <location>
            <begin position="321"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="515" mass="55735" checksum="4CBA954CE5D0A9FF" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMV6</accession>
    <name>A0A074ZMV6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_04699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167767.1">
        <property type="nucleotide sequence ID" value="XM_009169503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMV6"/>
    <dbReference type="STRING" id="6198.A0A074ZMV6"/>
    <dbReference type="GeneID" id="20318881"/>
    <dbReference type="KEGG" id="ovi:T265_04699"/>
    <dbReference type="CTD" id="20318881"/>
    <dbReference type="OrthoDB" id="6283668at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="117"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="243" mass="28254" checksum="9A0F9C40D9745B73" modified="2014-10-01" version="1">MQLNLSFMMFFNSRILEFRSLLSKSRQTPDSMEQVSDLVMESVLWVFCFPGEKGIGVLVDPKLLPPRERKKYEEGWFRHAFNQFISDRISVRRYLTDVREGLCRTQKFPANQPATAVVICFHNECWSTLLRSVHSVLDTVPENLLKEIVLVDDFSTYEYLKSPLDRYMKQLKKVKVIHTDKREGLIRARMIGMNASTAEILTFLDSHIECNKGEFFKSSSKFAFLANSFGTMLLSEVLKRETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNK0</accession>
    <name>A0A074ZNK0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_13530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="KL596694">
        <property type="protein sequence ID" value="KER28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167592.1">
        <property type="nucleotide sequence ID" value="XM_009169328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNK0"/>
    <dbReference type="STRING" id="6198.A0A074ZNK0"/>
    <dbReference type="GeneID" id="20327697"/>
    <dbReference type="KEGG" id="ovi:T265_13530"/>
    <dbReference type="CTD" id="20327697"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="297" mass="33939" checksum="40F35FFA719625EC" modified="2014-10-01" version="1" fragment="single">MNVRRTIRLAAGGFVSALAAFEAQVNLRNFQQTDNVKDDTSRSFLLRAKSFLQPFNALSSACAQTTTIPPKVTPWDWNWDGRHPQSSVVQATGDNSDGQLKRNTCSRHLIFIRHGQYHYAESDEECRLTQLGREQLDLTGLRLKHLKFPYSIVHYSTMTRAVESTEEVLKHLPGVKAIPSDLLREGAPYPLEPPLPYYRPTAEELKRDGDRIETAFKSFVHRPDCGQTRDTYEIFICHANVIRYFVCRALQFPPEAWIRFSLDHGSITWLVIRSDGRVVLRCLGNSGYMPQEKISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP49</accession>
    <name>A0A074ZP49_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168665.1">
        <property type="nucleotide sequence ID" value="XM_009170401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP49"/>
    <dbReference type="GeneID" id="20319585"/>
    <dbReference type="KEGG" id="ovi:T265_05403"/>
    <dbReference type="CTD" id="20319585"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15384" checksum="13679B5564DAE773" modified="2014-10-01" version="1">MDHHKESVGIREIQRESKLTELSRKHSMTSQIKSWKVPLHMDGRKHATSGPTSREDECGDAYIFFDVAGFSLYFYCRKVGEHWGSFLSQENLCQIASLSSKTDVKKCDQEKLGHSASKRRSFSKPDELRLSCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP84</accession>
    <name>A0A074ZP84_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167057.1">
        <property type="nucleotide sequence ID" value="XM_009168793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP84"/>
    <dbReference type="GeneID" id="20318321"/>
    <dbReference type="KEGG" id="ovi:T265_04135"/>
    <dbReference type="CTD" id="20318321"/>
    <dbReference type="OrthoDB" id="10353877at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="179" mass="20589" checksum="0B883113925BE2A1" modified="2014-10-01" version="1">MNGRITKDLKTIWTSIHNFPPVNSFISTVWYDSDPRTNEAVDMTEFEWRVDPFTPDEPLALAQVAKKVLIASSLARTSTREVLCEYFSKSETRILRAKFKDCSVEEQAFVIKFDSIPHACFNERREKTSVNVFLSCTFMFTCLRDIGTVQNAGFVSKRLYEAHQCHMKVHQRLCDSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ21</accession>
    <name>A0A074ZQ21_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596677">
        <property type="protein sequence ID" value="KER29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166752.1">
        <property type="nucleotide sequence ID" value="XM_009168488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ21"/>
    <dbReference type="GeneID" id="20318083"/>
    <dbReference type="KEGG" id="ovi:T265_03896"/>
    <dbReference type="CTD" id="20318083"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="270" mass="30641" checksum="D833A6DAAC9159F0" modified="2014-10-01" version="1">MLRTHFQSHGKTLSHGEEQCYGQIPIKQLRGTLSETNYGETIDQITRIAFGQPLPLTAIPSSQLLGLFANQITGEKHFARQTVLQRVEYMSQPALLLDIADSVTQPTPDFDNVIAWDKKWKTSRPLVPSINKTITKLTKMDSYIQMRTTITMISEHHQMTNPSLSHGGLVLTLKQIDGTYLEVQANIQLSQHLLDCIDHTVNQDNVGSQSEETHLSINPLGLDDVHKACIPSRPYWVNVSQLFLELRTRVPAEKSWFVWPLLIRMDSNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ84</accession>
    <name>A0A074ZQ84_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neurofascin/L1/NrCAM C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166999.1">
        <property type="nucleotide sequence ID" value="XM_009168735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ84"/>
    <dbReference type="STRING" id="6198.A0A074ZQ84"/>
    <dbReference type="GeneID" id="20318275"/>
    <dbReference type="KEGG" id="ovi:T265_04089"/>
    <dbReference type="CTD" id="20318275"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Neurofascin/L1/NrCAM C-terminal" evidence="6">
        <location>
            <begin position="541"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER29241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="647" mass="72674" checksum="AF9682A25371081D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQE1</accession>
    <name>A0A074ZQE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170694.1">
        <property type="nucleotide sequence ID" value="XM_009172430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQE1"/>
    <dbReference type="STRING" id="6198.A0A074ZQE1"/>
    <dbReference type="GeneID" id="20321188"/>
    <dbReference type="KEGG" id="ovi:T265_07009"/>
    <dbReference type="CTD" id="20321188"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="10"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="217" mass="24013" checksum="C64011694D681019" modified="2014-10-01" version="1">MGIILDFHDCLLRDEDLVTLNEGEWVNDNIIQFAMEYLRRTLLATVDNVLLVDPAVTQIVKLADARSVAMVLDSLNCKHIDWIFYAINDSLSTTSSGGTHWSLLVMSPTHEKSYHLDSLPSEGNYGCALKIADAMAEHCDRSGLRTVLQTNVAKQRNSWDCGLYVIVFLEILCKNLFETKGSALMLDSVASESVSSSVLSKRSVLKKLIAKLSSADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQF6</accession>
    <name>A0A074ZQF6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170709.1">
        <property type="nucleotide sequence ID" value="XM_009172445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQF6"/>
    <dbReference type="GeneID" id="20321203"/>
    <dbReference type="KEGG" id="ovi:T265_07024"/>
    <dbReference type="CTD" id="20321203"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="10582" checksum="6F64295908E5CD9D" modified="2014-10-01" version="1">MGAQTKDRLHGRPAGLSTIILTIAKVATTVTIRGGGKHYRVNSQAGSVTKFDRQTAFPTNGTQQPVVHQVWPDPSLAVFVDVALDGLEILACEKHKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQU4</accession>
    <name>A0A074ZQU4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596672">
        <property type="protein sequence ID" value="KER29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166498.1">
        <property type="nucleotide sequence ID" value="XM_009168234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQU4"/>
    <dbReference type="GeneID" id="20317879"/>
    <dbReference type="KEGG" id="ovi:T265_03692"/>
    <dbReference type="CTD" id="20317879"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="235" mass="25811" checksum="51CB54B99DC13AD2" modified="2014-10-01" version="1">MRIQDVEPQGSVVYKVPHDFPGARWPKWLEREFTDRKVHGSNPTSASRLPLSRLGQPGSIPALVLPSGGMAARHRKAVAPLRCLAALPHEGGTRAGILPGCPSLGRGRARTMDFSVVRLWLVNLDFALVGSREVKKSKSFSSNTLSVPSCHTIRTKHEGWDTVRLPKPGQRKSRGRESGSTMDLPFTSVTKTTLFLVDDALTCTDLPCIAYDSGQTCYLRISLCVNVHSFFKCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRM6</accession>
    <name>A0A074ZRM6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596760">
        <property type="protein sequence ID" value="KER26000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170287.1">
        <property type="nucleotide sequence ID" value="XM_009172023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRM6"/>
    <dbReference type="STRING" id="6198.A0A074ZRM6"/>
    <dbReference type="GeneID" id="20328267"/>
    <dbReference type="KEGG" id="ovi:T265_14101"/>
    <dbReference type="CTD" id="20328267"/>
    <dbReference type="OrthoDB" id="10519669at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="109" mass="12722" checksum="46605913213C0EB2" modified="2014-10-01" version="1" fragment="single">TRLHTFIKETTHKVAENSPTSRDRFHPSWGSSGRRSPRVSVNLMFYLNPNCTVFEKYTNMQINLFIQQPPTLCFTGDKIARKSINVLISTSIWFSRESQPKTSFMIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSC6</accession>
    <name>A0A074ZSC6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166166.1">
        <property type="nucleotide sequence ID" value="XM_009167902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSC6"/>
    <dbReference type="GeneID" id="20317605"/>
    <dbReference type="KEGG" id="ovi:T265_03418"/>
    <dbReference type="CTD" id="20317605"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="158" mass="17573" checksum="8252E474D00F61BE" modified="2014-10-01" version="1">MPNSEWRKQRGDKPLTEGDHETLGCCRCFPPSGMGIALSNKSWLYDSKASVLNIGVMLSMMMMMMMNVYHELDKKQISVDCGVNNNNNNNNNNNNRSAVALFRCLAAMPPGGSARARILPGRRSLDRGSRVTEVGFEPRAFRSVNSRSNHLGHFAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT00</accession>
    <name>A0A074ZT00_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_06231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169705.1">
        <property type="nucleotide sequence ID" value="XM_009171441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT00"/>
    <dbReference type="STRING" id="6198.A0A074ZT00"/>
    <dbReference type="GeneID" id="20320413"/>
    <dbReference type="KEGG" id="ovi:T265_06231"/>
    <dbReference type="CTD" id="20320413"/>
    <dbReference type="OrthoDB" id="7930430at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER26510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="204" mass="22761" checksum="25B5B9EFB5569A8F" modified="2014-10-01" version="1">MDIPNNHSCTLCGKLVTTKHGMVRHMRIVHQGAEESKCESCGRSFTTKFALHRHIRKVHEGITERVLPCDCCGKKFSAKHGLERHMRLIHESAELCICPLCNKTFSTKFAFNRHTKTVHATSLILCSPCSLLFPSKFALLEHNLSVHNTSKIFACPECLKCFPDAETRRVHHQEEHGANHSLLGVCSTNPSVQNPLAGASGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZUY9</accession>
    <name>A0A074ZUY9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164974.1">
        <property type="nucleotide sequence ID" value="XM_009166710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZUY9"/>
    <dbReference type="GeneID" id="20316649"/>
    <dbReference type="KEGG" id="ovi:T265_02461"/>
    <dbReference type="CTD" id="20316649"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17329" checksum="3F79625A4DEED961" modified="2014-10-01" version="1">MRHCTLSLIEPYERDPRLASVDVNSFGSELIVTMRKNCEPPVRTGFNICVSNASLKAGSLRFRSAVKTRDKLSKDWFTPVLFLIVFGVFLLAGIDAILGEFASDPVAFGNLYLKVPCKVCGKPPIFLPEDTDKENALLCFPFTNDDIILTSPRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW57</accession>
    <name>A0A074ZW57_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597209">
        <property type="protein sequence ID" value="KER19434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176820.1">
        <property type="nucleotide sequence ID" value="XM_009178556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW57"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325962"/>
    <dbReference type="KEGG" id="ovi:T265_11794"/>
    <dbReference type="CTD" id="20325962"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704367" description="Peptidase C13 family protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49575" checksum="BD1A13A0D4291018" modified="2014-10-01" version="1">MMRRCSLLVAFLFCINHLARLNAVGVHNWSSKFNNNLSKNWVVLVAGTNTWRNYRHQADVFHAYQVVRKNHVPAEDIITFAYDDIANNPKNPFKGKVFHDYLYEDIYQGVEIDYRGKVCASVGADGFLHQDVTLDNFVKVLKGDEQLAAYKKVLKSGPDDNVFIFYSGHAACRAVERDSRPHVFKKKYNKLVLYVEACYAGSLFRTILPRNVGIYVTTASKENEKSWSIFCDDKDIDVCLASEYAYAWIEDSENHDFKKHTLDQQYEKVKNRTVNSHVMKYDEMAMGSLPVGKFQGHYDLPMHGLDRTIPPNAVDRKPSLQAHLLSKSRRLMEATTQQVHEAAWRKLHRATEETFRDIVGDVMTHHNPPLKGLTKKDELMCFQAVFEQFRTHCFTIQQFPEVAQHTTHLMALCKAGYMAESLIDSVYNLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW68</accession>
    <name>A0A074ZW68_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine Rich repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168682.1">
        <property type="nucleotide sequence ID" value="XM_009170418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW68"/>
    <dbReference type="STRING" id="6198.A0A074ZW68"/>
    <dbReference type="GeneID" id="20319602"/>
    <dbReference type="KEGG" id="ovi:T265_05420"/>
    <dbReference type="CTD" id="20319602"/>
    <dbReference type="OrthoDB" id="271226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF3">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52294" checksum="5C3E924A3DAC1444" modified="2014-10-01" version="1">MSSSDETHNLEEGQNFEEIDDEEAGKYDRNESYAEETLPRESLSKEIISECISMPYRLGYGFSHAFVKLDCSDRRLSDIEILRGYIHLRFVILTNNFITDISPVSHIGHLIYLKADNNQIERADCLNKLRFLQYLDLSGNKLTTINDLKLPFLQHLKVNENAIGTLNSTGYGIPPEQFPALATLELRSNRLTSFEGIGALTTLTSLYCAENSLKDTSGLSKLTGLVRLHARDNRISSLNGITVAMSKNAIGTLNSTGYGIPPEQFPALATLELRSNRLTSFEGIGALTTLTSLYCAENSLKDTSGLSKLTGLVRLHARDNRISSLNGITVAMSSLEYLNLRGNRLSSFRAVKLLSALPSLKVLNLLQNPICDKDEYRLTVIGLISRLQKLDKERVTDSERADGASVVANKSDWDEDASEAEAMEEHHNAEGLAEEVGEEGGEVPNEQQPAEDQEDENAEEEGEGEEEEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZY75</accession>
    <name>A0A074ZY75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163772.1">
        <property type="nucleotide sequence ID" value="XM_009165508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZY75"/>
    <dbReference type="GeneID" id="20315655"/>
    <dbReference type="KEGG" id="ovi:T265_01467"/>
    <dbReference type="CTD" id="20315655"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="174" mass="19591" checksum="29078D6B7B9E09D4" modified="2014-10-01" version="1">MLKPELLALSMDDIFTLTRSPGAAYTMGLSLIRKTNVQQSYPRMLYGLPPTSICLFYFCECKPIPIRHNIPDTYGLTGEPFDESLSTYTSVVQTQPETLIYEQKLSQPTEPALFRLLSFPPLLQIFNLLDCSSTCLSNHIREKKGKKTVGIFIRSEDLPSSRGQVFNLAIPPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYI1</accession>
    <name>A0A074ZYI1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec7 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596700">
        <property type="protein sequence ID" value="KER28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167857.1">
        <property type="nucleotide sequence ID" value="XM_009169593.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYI1"/>
    <dbReference type="GeneID" id="20318950"/>
    <dbReference type="KEGG" id="ovi:T265_04768"/>
    <dbReference type="CTD" id="20318950"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF376">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="307"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="695"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
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        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
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        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1451" mass="156781" checksum="E75B7DA0AAE77937" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYK6</accession>
    <name>A0A074ZYK6_OPIVI</name>
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        <recommendedName>
            <fullName evidence="9">BOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167803.1">
        <property type="nucleotide sequence ID" value="XM_009169539.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYK6"/>
    <dbReference type="GeneID" id="20318908"/>
    <dbReference type="KEGG" id="ovi:T265_04726"/>
    <dbReference type="CTD" id="20318908"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="530"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2013"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1133"/>
        </location>
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    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1457"/>
            <end position="1548"/>
        </location>
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        <location>
            <begin position="1693"/>
            <end position="1720"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="554"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="1859"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2089" mass="232326" checksum="69C8BCBCA5543B45" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ12</accession>
    <name>A0A074ZZ12_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Repair protein Rad1/Rec1/Rad17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_02531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596649">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009166794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZ12"/>
    <dbReference type="STRING" id="6198.A0A074ZZ12"/>
    <dbReference type="GeneID" id="20316719"/>
    <dbReference type="KEGG" id="ovi:T265_02531"/>
    <dbReference type="CTD" id="20316719"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22379" checksum="395B40FF9AAF09B2" modified="2014-10-01" version="1">MEAFEILDFDFSSSTSPDKVIIKSDCIREAFSELDMSSEILELGLLPAPAAQPRLRLTTYGSSGTTHFDLPRSSDQVEVFEVRPGHPRLARYRLSLLRPAINRALTLATRISIRINERGFLSMQHMINLLDGQVAFVEFFCVPDEDDTDNPPDDESPQTTNHVNMQPPNGSSSRMLHNHYSADGRQQEQSVWDPDWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZ36</accession>
    <name>A0A074ZZ36_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SFR19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
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                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Maleewong W."/>
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                <person name="Sternberg P.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13630" checksum="BF790633254792F8" modified="2014-10-01" version="1">MINEQENVGGSVSVDEQKGGWDCGTLRVPEGDSYGSNTELQQQSSNKPQGELSLNLIQDDEGTLQHHRTAEEGIGQTWRRPCTRIKERNATRRRHDTSSLISIHEEQEGRKFDLENAKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1C8</accession>
    <name>A0A075A1C8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596988">
        <property type="protein sequence ID" value="KER21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175080.1">
        <property type="nucleotide sequence ID" value="XM_009176816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1C8"/>
    <dbReference type="STRING" id="6198.A0A075A1C8"/>
    <dbReference type="GeneID" id="20324609"/>
    <dbReference type="KEGG" id="ovi:T265_10441"/>
    <dbReference type="CTD" id="20324609"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15066">
        <property type="entry name" value="7tmA_DmOct-betaAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="425" mass="48499" checksum="F54CB47946CADD54" modified="2014-10-01" version="1">MLRGEAFDQFEAAKRSSNGTSEQLSQIFKGLCFSLIIFAALFGNALVFIAVQRFERLRRVKTNIFLVSLAMADFLVALVVMPFSACMSLMHGRWIFGNWFCDVFNANDVLFSTASILHLCCISMERYIAIINPLSYDRKMTKSRVTLMITTTWILSILISYLPIMSGIYTTAEYLAQRGSQHEVCEFVVNPIYAVVSSSTSFTIPSIVMVAVYVRIYIEARRQERKIHHLHLSKKLKTSSDATTYTTEQPRGSVEKETTVPENLTNLLMRASETNHQPITNRMSPPSIPNQSLESREHLKIHRENKAAKTLGIIIGAFILCWCPFFFWYISTNVCRAFADCPYPSILGEVLFWIGYFNSTLNPIIYAFYNRSFRRSFKHILQCHVTVKRAAQAKIDRTHSPSLRRSAQAGYLTSMQPMNRSDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1K6</accession>
    <name>A0A075A1K6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Adenosine kinase</fullName>
            <shortName evidence="10">AK</shortName>
            <ecNumber evidence="3 10">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_10359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="KL596979">
        <property type="protein sequence ID" value="KER21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174970.1">
        <property type="nucleotide sequence ID" value="XM_009176706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1K6"/>
    <dbReference type="STRING" id="6198.A0A075A1K6"/>
    <dbReference type="GeneID" id="20324527"/>
    <dbReference type="KEGG" id="ovi:T265_10359"/>
    <dbReference type="CTD" id="20324527"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="11">
        <location>
            <begin position="42"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="347" mass="37958" checksum="BE4CBF2C54EC84DC" modified="2014-10-01" version="1">MKAGEVRILGLGNPLLDLMVKAEGDIYDRYKLKKDDALLAAEHHLPLFDEVAQNPTTRYAAGGATLNTMRMIKWILQEPHKCTFIGCIAADEAGERLRNECEKLQLMTHFEVTQGEAATGKCAVLLHGKCRSMVTHVGAAANLTMDHILKPDTWHSIESASAYYVAGFATGTCFEGVLEVAKHARSRGKLFAFNLSSPAILQHFKDQMDAIFPYVDILFGNSSEAQAYAELHELSGQALENIVLKLASITSAKSENPRKRIVLITQGQDPVLLGESGGKEVMHFPVYPVSDEDIVDTNGAGDAFVAGFLAEYLRGSSIEKAVEEAINAARYIIQRNGFTLGPRDQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Z3</accession>
    <name>A0A075A1Z3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162443.1">
        <property type="nucleotide sequence ID" value="XM_009164179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Z3"/>
    <dbReference type="GeneID" id="20314594"/>
    <dbReference type="KEGG" id="ovi:T265_00406"/>
    <dbReference type="CTD" id="20314594"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="10979" checksum="C88AAE9314BC9CAB" modified="2014-10-01" version="1">MDDEEKEKHCTAVSSLLGVMSTSRVTRGIRILSLPASTLNRSAPSGCSASSSILSVPSCHAIRRKREGWDTTRLPKPRQGKSRGRCRIRTTDLPVIKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2Q2</accession>
    <name>A0A075A2Q2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166437.1">
        <property type="nucleotide sequence ID" value="XM_009168173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2Q2"/>
    <dbReference type="GeneID" id="20317825"/>
    <dbReference type="KEGG" id="ovi:T265_03638"/>
    <dbReference type="CTD" id="20317825"/>
    <dbReference type="OrthoDB" id="10608007at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="18071" checksum="DE3382F607CEEBCC" modified="2014-10-01" version="1">MSSRMVMKCLQVSRQARRTDKQLLDQIRTVREKQFLQMALNGQMDEVVNYRFGDRLSNHTQTPSDWTGQGNRRESWIIPPSAVRIQIPKKNTSNYSEDLNTLEDTLHLNTLIQFPVVFVLLTQPQQSIFKLPSLPISDTLSSISDNVLVRLDERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U9</accession>
    <name>A0A075A2U9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_00228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162200.1">
        <property type="nucleotide sequence ID" value="XM_009163936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2U9"/>
    <dbReference type="STRING" id="6198.A0A075A2U9"/>
    <dbReference type="GeneID" id="20314416"/>
    <dbReference type="KEGG" id="ovi:T265_00228"/>
    <dbReference type="CTD" id="20314416"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="553" mass="64032" checksum="5CEDBD86D13208DB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A324</accession>
    <name>A0A075A324_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_13263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596668">
        <property type="protein sequence ID" value="KER29980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166276.1">
        <property type="nucleotide sequence ID" value="XM_009168012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A324"/>
    <dbReference type="GeneID" id="20327430"/>
    <dbReference type="KEGG" id="ovi:T265_13263"/>
    <dbReference type="CTD" id="20327430"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17085" checksum="E5297A8F18F4CACF" modified="2014-10-01" version="1" fragment="single">MKDTVVTLAGVLLHSSVQKTARLFLNEHLRKVESRSDKSPSEGRERSEQAARWLSDWSANVLIGRSVVRIRPLPLDSPCLGLGNLALSQPSSFLLVARQLGTNRATVNSSTAQDRFRPSWGSSVRHNLRFPVNIMFKLNSNCTELAKHTHLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A369</accession>
    <name>A0A075A369_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596936">
        <property type="protein sequence ID" value="KER21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174390.1">
        <property type="nucleotide sequence ID" value="XM_009176126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A369"/>
    <dbReference type="GeneID" id="20324078"/>
    <dbReference type="KEGG" id="ovi:T265_09910"/>
    <dbReference type="CTD" id="20324078"/>
    <dbReference type="OrthoDB" id="6298486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704505" description="START domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18262" checksum="45CE693C87DEA7DA" modified="2014-10-01" version="1">MRTQLVCNALSEMLWQASLTLFIMSSVCDAIVTVYPFDAPYSDVKSMYVTTREPESTEWDDLCNWLRHKRPYGWQLGLIDRCQVHKQDRGTVTMKIELLFHKLPHLLHTVPTDLQSWALNWMFWVEKEPCITIVDVPGRVLFDSVQRKLLYKSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A399</accession>
    <name>A0A075A399_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166172.1">
        <property type="nucleotide sequence ID" value="XM_009167908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A399"/>
    <dbReference type="GeneID" id="20317611"/>
    <dbReference type="KEGG" id="ovi:T265_03424"/>
    <dbReference type="CTD" id="20317611"/>
    <dbReference type="OrthoDB" id="6324440at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="442" mass="49073" checksum="D80444B0A59ED34C" modified="2014-10-01" version="1">MAGISEQIKSRRLGHNLLVGVCDQGRKGNAFIAADVLLDCMPLELSHVGRVDCPAGYVQWVLHKDMMWNTHNVLDDVYLIPECAERTPDTSVGTLDRQPLLNYARAKITLHIPSNVALPCHTKEARGILPGRPSLDGEVERWRSGSNHGPFDQKLLTRLLKTLRQSTTGFAILGVHQIVVVGTKAGILPGCPSLDRGNRETEVGSEPWTFLSKCIHLSVYLVFPRHSTKSLVYDILQLSVMHIGRLMFHLARYLRYRSIFSLGKQLTSLLKTFRQPTTIIRVMLIYSVRDDDDDDDDDDDDGDDDDDNGDNDGDDGDGDDDDDDDDDDDDDDDDDDDDGDDDDSDGDVDDDELDVDDDDDVDDDDDDDSVHSPEGKKSASGKDIDSSGMESKNNSTTPLPGAEQGFTDKEQNYFITNKRTLVPSTTASGYFFEKHCPTLILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5V6</accession>
    <name>A0A075A5V6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596878">
        <property type="protein sequence ID" value="KER22824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173431.1">
        <property type="nucleotide sequence ID" value="XM_009175167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5V6"/>
    <dbReference type="STRING" id="6198.A0A075A5V6"/>
    <dbReference type="GeneID" id="20323340"/>
    <dbReference type="KEGG" id="ovi:T265_09161"/>
    <dbReference type="CTD" id="20323340"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="259"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="642"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="107350" checksum="768826892F7F6996" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A978</accession>
    <name>A0A075A978_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164034.1">
        <property type="nucleotide sequence ID" value="XM_009165770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A978"/>
    <dbReference type="GeneID" id="20315892"/>
    <dbReference type="KEGG" id="ovi:T265_01704"/>
    <dbReference type="CTD" id="20315892"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="273" mass="30872" checksum="FB8DF7809AFCAAA9" modified="2014-10-01" version="1">MLTERILYLWVTIIGLLIFEFCITHILQCSKWRFCPGSKSIQSCKAEEYCTAVLLLSRTKYSSHKTPKLQPKSCPVGFKLIWPSFDESGTPITSPKRKHVRLLRRNHSDASTCVWWTSGQMSEVQIPARDSTESLVYEILQLSVQHIGRLIIQLARYSRYHTMDSSSTLIGAKSGVNIEWRSFEGSSVLPTSLRREHVHMFKRENPNASSVRWWNSGSTLASHGRCSIPGGKLKCGHTRTIVRGQENVCSNKSYVSVRPTKIPQPPTPDGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AA85</accession>
    <name>A0A075AA85_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163651.1">
        <property type="nucleotide sequence ID" value="XM_009165387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AA85"/>
    <dbReference type="STRING" id="6198.A0A075AA85"/>
    <dbReference type="GeneID" id="20326936"/>
    <dbReference type="KEGG" id="ovi:T265_12768"/>
    <dbReference type="CTD" id="20326936"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="376" mass="42208" checksum="3A7751D916864088" modified="2014-10-01" version="1" fragment="single">MQRPLQLDIWENLEDVRFIAFCLLRLLTPQLTLAESAKDSFCDALGALRAKSSDTVVVDGGMNAQVGRLSAAETRLGGRLGLDTRRTDNGDRLLQMYANHRLSLCSTNFRNSGNRLTTWCPPTNQSRIQADHITVGYRWRGSTTAWPSFWNTRLDPENVLVCCCFLFRFSGTECVRLLADVAALTAEAERSQQRARSTGPSDAEQKRFEAELSKLEKTVKQKVDLASKKRMEAESLKAQLLDVGSARLTAVRSRLDAIEKKTKETNDQLTKLQVGVKTAARNFEKSKSKVASIEAELEAAKQKLTDVDAKLKDLEEEARTCMDEFKKIQADVNVYFSLGLCPFHISTVYAYMATLVKSVVRTFDGLVSRLIENIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAT0</accession>
    <name>A0A075AAT0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_07745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171608.1">
        <property type="nucleotide sequence ID" value="XM_009173344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAT0"/>
    <dbReference type="STRING" id="6198.A0A075AAT0"/>
    <dbReference type="GeneID" id="20321924"/>
    <dbReference type="KEGG" id="ovi:T265_07745"/>
    <dbReference type="CTD" id="20321924"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="208"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="208"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="865" mass="93346" checksum="D80E84FCFBED1944" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACN5</accession>
    <name>A0A075ACN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596773">
        <property type="protein sequence ID" value="KER25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170688.1">
        <property type="nucleotide sequence ID" value="XM_009172424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACN5"/>
    <dbReference type="GeneID" id="20321182"/>
    <dbReference type="KEGG" id="ovi:T265_07003"/>
    <dbReference type="CTD" id="20321182"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="74039" checksum="BB284BD1E8FA786E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACY5</accession>
    <name>A0A075ACY5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_12520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596621">
        <property type="protein sequence ID" value="KER33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162420.1">
        <property type="nucleotide sequence ID" value="XM_009164156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACY5"/>
    <dbReference type="STRING" id="6198.A0A075ACY5"/>
    <dbReference type="GeneID" id="20326688"/>
    <dbReference type="KEGG" id="ovi:T265_12520"/>
    <dbReference type="CTD" id="20326688"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="326" mass="37146" checksum="EE71AD5890A3640F" modified="2014-10-01" version="1" fragment="single">MKIQPSWTYVSRETDTDRVAIYDLKLRNLPKPIACKLTHTKRRISVSHYRILFDHITFVIEFTCTGWLGAHYHTLGKCRMGAKGRCFSRKWRSKQKDMTMLKVMNEVAKMPGELSTEGRNLLSVAYKNVIGAKRSSWRMLSSIEQKDGDENSPEAQAQRMLQTTVEKELSEVCGSILSLLDKHLIPSAQTPECKVFFYKMKGDYERYLAEIASGDARKQAAENSLVAYKAASDIASQELQTTNPVRLGLALNFSVFYYEILNNPHRACQLAQEAYKLAVDDLDKLRDENYKDTTLIMQLLRDNLTLWNSDIQGDETADTVQPVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD58</accession>
    <name>A0A075AD58_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162272.1">
        <property type="nucleotide sequence ID" value="XM_009164008.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AD58"/>
    <dbReference type="GeneID" id="20326652"/>
    <dbReference type="KEGG" id="ovi:T265_12484"/>
    <dbReference type="CTD" id="20326652"/>
    <dbReference type="OrthoDB" id="6241182at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1541" mass="172530" checksum="0A888CEC620954A4" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADD3</accession>
    <name>A0A075ADD3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596619">
        <property type="protein sequence ID" value="KER34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162102.1">
        <property type="nucleotide sequence ID" value="XM_009163838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADD3"/>
    <dbReference type="STRING" id="6198.A0A075ADD3"/>
    <dbReference type="GeneID" id="20326590"/>
    <dbReference type="KEGG" id="ovi:T265_12422"/>
    <dbReference type="CTD" id="20326590"/>
    <dbReference type="OrthoDB" id="7103806at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="937" mass="105694" checksum="2CFF6F68763FB7EF" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADU6</accession>
    <name>A0A075ADU6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tumour suppressor p53-binding protein-1 Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596751">
        <property type="protein sequence ID" value="KER26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169932.1">
        <property type="nucleotide sequence ID" value="XM_009171668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADU6"/>
    <dbReference type="STRING" id="6198.A0A075ADU6"/>
    <dbReference type="GeneID" id="20320589"/>
    <dbReference type="KEGG" id="ovi:T265_06410"/>
    <dbReference type="CTD" id="20320589"/>
    <dbReference type="OrthoDB" id="6254149at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015125">
        <property type="entry name" value="53-BP1_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09038">
        <property type="entry name" value="53-BP1_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tumour suppressor p53-binding protein-1 Tudor" evidence="2">
        <location>
            <begin position="350"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="948" mass="103740" checksum="970DCA3F02A96A65" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEA0</accession>
    <name>A0A075AEA0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596744">
        <property type="protein sequence ID" value="KER26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169698.1">
        <property type="nucleotide sequence ID" value="XM_009171434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEA0"/>
    <dbReference type="GeneID" id="20320408"/>
    <dbReference type="KEGG" id="ovi:T265_06226"/>
    <dbReference type="CTD" id="20320408"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="190" mass="21717" checksum="31DE8E1C767B37CD" modified="2014-10-01" version="1">MELCGNPDCLSKNRVPENNVSLNQWINSSLSYSMSYTRYICKLFVCVSWRMEYSNGDPTSYRVRPMMSVCAKRWGDCTGTKEKPDKFEITYGKQQLVLQVKHVSNPRVGCKYRQIHSTKRWNTGAVDCFLLLVFLGNDTCQLQAGQLQDRRTPKLATVTPKGGAEKKSIDDGKRDQMQCREIGQQLLSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHB7</accession>
    <name>A0A075AHB7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596675">
        <property type="protein sequence ID" value="KER29604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166639.1">
        <property type="nucleotide sequence ID" value="XM_009168375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHB7"/>
    <dbReference type="GeneID" id="20317991"/>
    <dbReference type="KEGG" id="ovi:T265_03804"/>
    <dbReference type="CTD" id="20317991"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="113" mass="12532" checksum="4C1905A7815AA2FD" modified="2014-10-01" version="1">MSIIPENCAAHKRTRVSTHQQQRLASINAETTAKLSLIDHNSTRLCIHATSELNDLLKPSIFAVEYNERITKTLEPSEHTMGLCLLEIDELASENSRIADLHGAPQKESPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHX1</accession>
    <name>A0A075AHX1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596658">
        <property type="protein sequence ID" value="KER30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165619.1">
        <property type="nucleotide sequence ID" value="XM_009167355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHX1"/>
    <dbReference type="STRING" id="6198.A0A075AHX1"/>
    <dbReference type="GeneID" id="20317164"/>
    <dbReference type="KEGG" id="ovi:T265_02976"/>
    <dbReference type="CTD" id="20317164"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25591" checksum="A0602C6EB1463B03" modified="2014-10-01" version="1">MMPPRVVMKRLHTDCQARQLDQQPLDQRSVEWVTCTFTNLFEGSFGSDVQYGRYTWRCAEALSQYIVGNCEQVHGKRILEVNLGAGTGLCGLVASLCGASWVTFSDRDHTLEGDLLRSAQSNGITQFDFCVLDWEFPTRYWRPRPFDLILASDTLFDKRGKLTAQTAALLLSSLTDAYLLLSIEPRCSFTDISILMKKYSLCSKLECAQTSRCEPIQIYRVEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI15</accession>
    <name>A0A075AI15_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165368.1">
        <property type="nucleotide sequence ID" value="XM_009167104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI15"/>
    <dbReference type="GeneID" id="20316967"/>
    <dbReference type="KEGG" id="ovi:T265_02779"/>
    <dbReference type="CTD" id="20316967"/>
    <dbReference type="OrthoDB" id="6251275at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="337" mass="39265" checksum="5C00CE1A766E954F" modified="2014-10-01" version="1">MSMKLGPSPGKCPRYDGRDRQEHDRHFKNQEYRSAFQNKPGRRTSEKSRSSLRSPSEEIQTTTEGLLFATQTDQSMTYPIYRFYNPTSRGYLSDQKKTHLVCANNRNPLDAYVEWEWIAFESYPFGYLRNHQSKRYLCFNVNGRPVMLKQIRHFSKCLLRINVALKSDRPHRKLVNDEQRSPQNMQQEVVGRSGEITWGVVSKRTNIHQALLLKEEQPLTTGTLRQSERTLNLPERTHPPQISLPQFMWLTTAKHLPEWKLLFCPNGMPFAHYRPHHKRCRHTDLSGNSQQLIMCPRIPSRCRLACAPHIFKQEIKAGELQCDMKCLQAISCSPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIT7</accession>
    <name>A0A075AIT7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin polymerization-promoting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_01638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163968.1">
        <property type="nucleotide sequence ID" value="XM_009165704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIT7"/>
    <dbReference type="GeneID" id="20315826"/>
    <dbReference type="KEGG" id="ovi:T265_01638"/>
    <dbReference type="CTD" id="20315826"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18073" checksum="1404EFBC51B0140E" modified="2014-10-01" version="1">MTTELHNSFNSFCNFVKKGSTTATDKTLKKICTDCHIYGKGLDANRVDIEFRAFIGNTKRYVDFKEFLEFVDGRLAKVYASSNGITQEEAAAELRRKIADTNPVAHGATKVSADATTSRLTDVKGFTGSHKERFDLETGKGRGKEGRENKPPAFTTTGISAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIY6</accession>
    <name>A0A075AIY6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163807.1">
        <property type="nucleotide sequence ID" value="XM_009165543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIY6"/>
    <dbReference type="STRING" id="6198.A0A075AIY6"/>
    <dbReference type="GeneID" id="20315690"/>
    <dbReference type="KEGG" id="ovi:T265_01502"/>
    <dbReference type="CTD" id="20315690"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052794">
        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="420" mass="46532" checksum="293F3EEF023EA174" modified="2014-10-01" version="1">MRFPTILYAAAAALHVIEPSATVDRHDGFGFANVENLVPVREDTLFRIASISKSFTSVLVGRLMEQSKLDLDEDIRTYLPQFPEKQVDGTYAKITARSLLSHTSGIRSYKKSAEERGQSSYPEMLLQTRYDNALDACSLFKDDPLVHAPGKQYTYSTFGFTLLSAAIENICTRSGPSFACSLGTQPYCVKTNSDTSKIPCFAKMDHQFSKLFTFLGLKNTFLEYHEKIMPVRASQYKRNSKGVLENTPMVDNSYKWAGGGILSTAYDLTLFANHLAYVYLDSMPMTGVIKPETLRLLWTVSASNPDEDWQPGLGWFLRRRSGGSLSQEMTCPDRLYVCHTGGAVGGTTILLLSLPCCKLLSGHEYVREDALSNPSDFTARSAKLAPICVAVLTNLEDASGIKELAVSLVELVTDCILRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YU79</accession>
    <name>A0A074YU79_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL604889">
        <property type="protein sequence ID" value="KER18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177985.1">
        <property type="nucleotide sequence ID" value="XM_009179721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YU79"/>
    <dbReference type="STRING" id="6198.A0A074YU79"/>
    <dbReference type="GeneID" id="20330339"/>
    <dbReference type="KEGG" id="ovi:T265_16174"/>
    <dbReference type="CTD" id="20330339"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="41" mass="4610" checksum="ABA989F53C01654E" modified="2014-10-01" version="1" fragment="single">MNTVLDDNKMLCLANSERIKLTNYVHMLFEVQDLAVASPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUC1</accession>
    <name>A0A074YUC1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL603791">
        <property type="protein sequence ID" value="KER18308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177945.1">
        <property type="nucleotide sequence ID" value="XM_009179681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUC1"/>
    <dbReference type="GeneID" id="20330311"/>
    <dbReference type="KEGG" id="ovi:T265_16146"/>
    <dbReference type="CTD" id="20330311"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7968" checksum="6E09A98FD69AFA43" modified="2014-10-01" version="1" fragment="single">LNPPKSTKHQIFHSPVLGTQFPSDLACCFAFPGPVALVPRLEISSAFFSSARELAVIRHNERRMQRCIFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVV5</accession>
    <name>A0A074YVV5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597538">
        <property type="protein sequence ID" value="KER18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177351.1">
        <property type="nucleotide sequence ID" value="XM_009179087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVV5"/>
    <dbReference type="GeneID" id="20329926"/>
    <dbReference type="KEGG" id="ovi:T265_15761"/>
    <dbReference type="CTD" id="20329926"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="123" mass="13957" checksum="1D0C5C681B8FD641" modified="2014-10-01" version="1" fragment="single">MSYQTNQHMRQTAEAILILLPSQNAGLDVSCIGETRTNGVLHEVPPYSDQNLIRLPGISQSFLAYYGFIFYTQYYPLPLTQHTNKQRTRHASGETHGPVYQLKPDSLRIESGKQNTRSSVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWF8</accession>
    <name>A0A074YWF8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597333">
        <property type="protein sequence ID" value="KER19101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177150.1">
        <property type="nucleotide sequence ID" value="XM_009178886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWF8"/>
    <dbReference type="STRING" id="6198.A0A074YWF8"/>
    <dbReference type="GeneID" id="20329825"/>
    <dbReference type="KEGG" id="ovi:T265_15660"/>
    <dbReference type="CTD" id="20329825"/>
    <dbReference type="OrthoDB" id="6270070at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="186" mass="20676" checksum="037BDCAA0344C0C6" modified="2014-10-01" version="1" fragment="single">MLPHVHLHTYRDLRSYSVCEGHRSAVINGTPRAYSYFLCPESLANRSHVYCCSDKTTHEGYCCPVEKWRTIVGITIISVAAFCAACVLGCVLLRKCRKCRLPTRSSRQSNSPPTAESDAHTPLNADALTPTPPRSSSQLRLHSLTTDRTRDIVDFAKSRLKEKPMDEPAPPPYPGHNSPPPYPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWI5</accession>
    <name>A0A074YWI5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597321">
        <property type="protein sequence ID" value="KER19126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177125.1">
        <property type="nucleotide sequence ID" value="XM_009178861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWI5"/>
    <dbReference type="GeneID" id="20326159"/>
    <dbReference type="KEGG" id="ovi:T265_11991"/>
    <dbReference type="CTD" id="20326159"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9229" checksum="635F07BFF84C9A08" modified="2014-10-01" version="1">MEAPNLMCLQQRRFSRLGGNGVGIKYPGVSWNQVEMADQSTIMVTHALDHVGRYKPGAQPHSVPFDHVSDLTREIQRWPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY44</accession>
    <name>A0A074YY44_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL611009">
        <property type="protein sequence ID" value="KER18107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178146.1">
        <property type="nucleotide sequence ID" value="XM_009179882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY44"/>
    <dbReference type="GeneID" id="20326542"/>
    <dbReference type="KEGG" id="ovi:T265_12374"/>
    <dbReference type="CTD" id="20326542"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10385" checksum="650033551A5C9A4C" modified="2014-10-01" version="1">MAIDTCALTHSCSELQNGCDFVCYVVDVLVPHWQRRTRVQRAKTMVNMFYRLQECCNLLECSNNGNLSGCSGQLTPPKLPALSVVETYLGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYF3</accession>
    <name>A0A074YYF3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597158">
        <property type="protein sequence ID" value="KER19668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176581.1">
        <property type="nucleotide sequence ID" value="XM_009178317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYF3"/>
    <dbReference type="GeneID" id="20325785"/>
    <dbReference type="KEGG" id="ovi:T265_11617"/>
    <dbReference type="CTD" id="20325785"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13112" checksum="5DBDD156614D327B" modified="2014-10-01" version="1">MLLDTFDLGIIPEIQSVASSEAQPEQGLQLRRWTDRIRKPVGPICLVHFGYAARQISGRRIDFVVSVCIRMNTANRHTVGTAHVFDTLITTADARESHGRRTDVAQKTTPVTSHSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZI6</accession>
    <name>A0A074YZI6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_15395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597093">
        <property type="protein sequence ID" value="KER20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176156.1">
        <property type="nucleotide sequence ID" value="XM_009177892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZI6"/>
    <dbReference type="GeneID" id="20329560"/>
    <dbReference type="KEGG" id="ovi:T265_15395"/>
    <dbReference type="CTD" id="20329560"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11992" checksum="7D0B985BA000496B" modified="2014-10-01" version="1" fragment="single">MHNAEDISKITHQVCSSWNVTDDNKYNSLQMAMIHSAWIDSRIRSDTDWFPPPICIYYPKMFDKRCCQIYSDCEGSLAPVLNAHRKAPSSKFALRLQVSLDPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z044</accession>
    <name>A0A074Z044_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597071">
        <property type="protein sequence ID" value="KER20288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175969.1">
        <property type="nucleotide sequence ID" value="XM_009177705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z044"/>
    <dbReference type="GeneID" id="20325299"/>
    <dbReference type="KEGG" id="ovi:T265_11131"/>
    <dbReference type="CTD" id="20325299"/>
    <dbReference type="OrthoDB" id="8862460at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="176" mass="19933" checksum="11DF9857D44F61D2" modified="2014-10-01" version="1">MSSQRSKSWLAAARVQHSCQELEALKRIFENELRDLRKQYEVTQADLAELKAKPAMSDVGEIVDDAAKYMLSIVSAMSDVGEIVDDAAKVTGFASPGSLMFQSLRYSRNRDTCIFVAENSPTTDNRSRHSWGLSDRRSPRVSVNLMFCLKPNCTKLEKYTHSQTNLVFRETHLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0I1</accession>
    <name>A0A074Z0I1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597056">
        <property type="protein sequence ID" value="KER20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175799.1">
        <property type="nucleotide sequence ID" value="XM_009177535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0I1"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20325168"/>
    <dbReference type="KEGG" id="ovi:T265_11000"/>
    <dbReference type="CTD" id="20325168"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37700" checksum="44BA9682427DB36C" modified="2014-10-01" version="1">MDSENSTKSTDVPTTLVATAKEPEWLGNSDVFHAYHLVRKNKVPAENIITFAYDDIAKNRKNPFKGKVFQDYEHKDVYNGVVIDYRGRDVTPDNFMMVLKGDDKLEANKKKVLKSGPNDNVFIFFSGHGASSVIVFPGEELLAMELNDTLAYMRSKKMFNKLVLYVEACNAGSMFHDVLPSNMGIYVTTAANEDEDSSALFCSDKDIDVCLADEYSYEWLLDSEYKDIKTRTLDEQYEEVKRCTVFSHVMKYGEMRNAADRKPSCQAHLFTKSRRLFEAAREEAHEIAWHRLYRALQILEVAQQTSHLMELCKAGYEVEALIDCVHNICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0S7</accession>
    <name>A0A074Z0S7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RabBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597349">
        <property type="protein sequence ID" value="KER19072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177180.1">
        <property type="nucleotide sequence ID" value="XM_009178916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z0S7"/>
    <dbReference type="STRING" id="6198.A0A074Z0S7"/>
    <dbReference type="GeneID" id="20329837"/>
    <dbReference type="KEGG" id="ovi:T265_15672"/>
    <dbReference type="CTD" id="20329837"/>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051745">
        <property type="entry name" value="Intracell_Transport_Effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555">
        <property type="entry name" value="MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14555:SF3">
        <property type="entry name" value="RABBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="6">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER19072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47711" checksum="93F3A7361AFE1DEF" modified="2014-10-01" version="1" fragment="single">MLPSQKSSSLERAISKIDLSHLSEEERAKVLNVVQRDLQVRVVEKERLKRYRTSLLRRDREVAAKSQALAESYNCLLCGQKFILLINPRMQCKNCGRQICRRCSETVTEVNGPLCRLCLRETGYRAMRCNWFYDTVISRFREFGSTAVAKSIFGDKYQHIQNIAEDELANIISMYGSNENDGDVIVNEQKVPSQSLEQAKDVQLKRLRTKLESLMQNTMKEFQLVDQDRNLTDQQKYWQGGRISVEFRKAAATQLRSFTQTFYIATERQRSSQGNSSRNVTQYVMNTLQQEVSRIVGHPIKDVEDNLSLASDDDLESVAYAEREGVEERLAQALLDKVLRDRQNYVSGVKKEVSRNTVSSSKPVPDIKITEDNGHSDVRSYFSNNIAIIKIGSFEITPIFNAVISKEFGGSFSSHSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z180</accession>
    <name>A0A074Z180_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="6">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_10816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KL597029">
        <property type="protein sequence ID" value="KER20703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175557.1">
        <property type="nucleotide sequence ID" value="XM_009177293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z180"/>
    <dbReference type="STRING" id="6198.A0A074Z180"/>
    <dbReference type="GeneID" id="20324984"/>
    <dbReference type="KEGG" id="ovi:T265_10816"/>
    <dbReference type="CTD" id="20324984"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="351" mass="39056" checksum="B018E5145076C5FA" modified="2014-10-01" version="1">MSLRRVSVIGSGNWGSTIAKIVGCNIQKCPGFEMEVRMWVFEEMINDKKLTEIINEKHENTKYLPGVRLPCNVVATPDLLHATQDADVLIFVLPHQFLQRVCHQMKPALKQGVYGVSLMKGLALSENGCIRLLTDLIREQLSIPCAVMMGANLASEVSQEYYCEATIAAATLDMGRELKQLFQTDYFRIVVIQDEVGTELCGALKNIVAVGAGITEGLGYGDNTKAAVIRLGFMEMKSFIYEFFGDRNPQESTFLESCGVADLITTCYGGRNKRMGYALATTNEPLDELEREQLGGQSAQGPLTAYEVYNMLKSRDLLSKYPLFTAVHRICTREMPASEFLSCLANHPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z2B6</accession>
    <name>A0A074Z2B6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596988">
        <property type="protein sequence ID" value="KER21166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175082.1">
        <property type="nucleotide sequence ID" value="XM_009176818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z2B6"/>
    <dbReference type="GeneID" id="20324610"/>
    <dbReference type="KEGG" id="ovi:T265_10442"/>
    <dbReference type="CTD" id="20324610"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="8344" checksum="A564E2F923F09BC9" modified="2014-10-01" version="1">MDPISPMGPKELHASSLGTVTTHTGPSNCHVLRLTIKIATYHSVNKNWYDESQTSNRGPPISFEMTDDLLDVRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3P8</accession>
    <name>A0A074Z3P8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596947">
        <property type="protein sequence ID" value="KER21691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174554.1">
        <property type="nucleotide sequence ID" value="XM_009176290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3P8"/>
    <dbReference type="GeneID" id="20324207"/>
    <dbReference type="KEGG" id="ovi:T265_10039"/>
    <dbReference type="CTD" id="20324207"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="450" mass="51556" checksum="CC7F06537C045E62" modified="2014-10-01" version="1">MLADGANKINSPCVKQMFIGGGNGKERRSPTDSDQLKTERTKSPPVSAGFSVVGRLNDLARGRTNQLGWLHTFVCVRNARSCMEMHFPTACTSLCRVLYKQRKAHIESCHLSRRNPRVSVNRERHKLEIQLSPSVNLLCGLDSGFLCPQTTQNEEIDDMKSEPHLSYFCGSHQSEDLIEEQHTPSSESIRPWDDSSNTFVSYSALNLYTPNHSTSDPVQSPKLHKSSRYTACDYLGHDPTLTSVRIFVHCLVALEPLHVRNGGFSLRPYRANTMNLFYLGYQRNSNNQREHNYLVVCMIQVTVPKRLNGKQPSSRYLKELQMKLLLYWRSPILTCLLDQQRRREVDCIHHKSYAEPARGDSAVWRRPWPQLSVEDGWICNRLASVHTLTQLVGERQEQNRPGKLGKKPRSCVSIRESENPFARFNRMMHCSDVIEFEEYAISIRTSDQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3T2</accession>
    <name>A0A074Z3T2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL620375">
        <property type="protein sequence ID" value="KER18005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178248.1">
        <property type="nucleotide sequence ID" value="XM_009179984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3T2"/>
    <dbReference type="STRING" id="6198.A0A074Z3T2"/>
    <dbReference type="GeneID" id="20330526"/>
    <dbReference type="KEGG" id="ovi:T265_16361"/>
    <dbReference type="CTD" id="20330526"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="59" mass="6808" checksum="7528C4A611DE2681" modified="2014-10-01" version="1" fragment="single">PNEDEGVETRRLGLSSITVENVKTKAPHSKDVETNPWVDRSEDMAYRKVTEQNFLQQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z440</accession>
    <name>A0A074Z440_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596936">
        <property type="protein sequence ID" value="KER21856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174401.1">
        <property type="nucleotide sequence ID" value="XM_009176137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z440"/>
    <dbReference type="GeneID" id="20324089"/>
    <dbReference type="KEGG" id="ovi:T265_09921"/>
    <dbReference type="CTD" id="20324089"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="98" mass="10483" checksum="3326406B3C541848" modified="2014-10-01" version="1">MVNGSSVQPSLEEKPKRTKIQFAPSCEGGVFSQYVVDVRYCGLSRPTASTQGRLAVGASSASTNINLNKTSSYTVPTLFGSHRGLTADDSERHKSFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4A6</accession>
    <name>A0A074Z4A6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20330446"/>
    <dbReference type="KEGG" id="ovi:T265_16281"/>
    <dbReference type="CTD" id="20330446"/>
    <dbReference type="OrthoDB" id="6233746at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7465" checksum="E70A98E28ECB7384" modified="2014-10-01" version="1" fragment="single">ALQNLCIGQRGQGVQKLLDSRLQSEPIPVARDAKRGVTTEEARDNWRRDHVKEAGQMNNILDQGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z522</accession>
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    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER18420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z522"/>
    <dbReference type="GeneID" id="20330233"/>
    <dbReference type="KEGG" id="ovi:T265_16068"/>
    <dbReference type="CTD" id="20330233"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="134" mass="15420" checksum="62ED650FA20A6E8E" modified="2014-10-01" version="1" fragment="single">MTGLDSGFQPDFRSEGDRAVQLSVLSSVTLINYRGCMHVCGIYFFSQDSSFMKQQKPQLICPEMSIVRTSLLRYLFYPYSEYVIHRDVGEIILNVEGAVVFDLLQFLVGLGFGVSPESQLFHDKRYRIRELLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5B0</accession>
    <name>A0A074Z5B0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Digenea</taxon>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5B0"/>
    <dbReference type="GeneID" id="20324968"/>
    <dbReference type="KEGG" id="ovi:T265_10800"/>
    <dbReference type="CTD" id="20324968"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER20707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="66" mass="7089" checksum="0AD3B1314EE88BD5" modified="2014-10-01" version="1">MASVEKASYGRSSGAAVGSRDPGETLMRDHRPVVEANFGQNRNRKKPALPALCTINRFGVPECCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5Y4</accession>
    <name>A0A074Z5Y4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596896">
        <property type="protein sequence ID" value="KER22488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173766.1">
        <property type="nucleotide sequence ID" value="XM_009175502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5Y4"/>
    <dbReference type="GeneID" id="20329008"/>
    <dbReference type="KEGG" id="ovi:T265_14842"/>
    <dbReference type="CTD" id="20329008"/>
    <dbReference type="OrthoDB" id="6273191at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="133532" checksum="1E0DB1297E11D69D" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z612</accession>
    <name>A0A074Z612_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">T265_15909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598865">
        <property type="protein sequence ID" value="KER18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009179329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z612"/>
    <dbReference type="GeneID" id="20330074"/>
    <dbReference type="KEGG" id="ovi:T265_15909"/>
    <dbReference type="CTD" id="20330074"/>
    <dbReference type="OrthoDB" id="10387330at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13546" checksum="BDC3B90ACA8B9D1E" modified="2014-10-01" version="1" fragment="single">QDKLLFKHDQPYTDNSSVCSGCGRGYKYFIFKNTCVIEEERPKFTCYHTHGIDFNKDAAGTHPNCGHCIYEETFEEGRLVAVSRMCVGRQCVSYEHVFDGNGQNRICCSGDLCNENKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z788</accession>
    <name>A0A074Z788_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596867">
        <property type="protein sequence ID" value="KER23051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173217.1">
        <property type="nucleotide sequence ID" value="XM_009174953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z788"/>
    <dbReference type="GeneID" id="20328886"/>
    <dbReference type="KEGG" id="ovi:T265_14720"/>
    <dbReference type="CTD" id="20328886"/>
    <dbReference type="OrthoDB" id="10425397at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="122" mass="13771" checksum="A76F374D115460B3" modified="2014-10-01" version="1" fragment="single">MNPSGTSIPVHHRQRKSRVKFRGFSAKKQLQQIVCVLYFSKTMEDSSRLNVLYQVASCFSRYDIRDIAIHQLKNEAAWCSTFSFLETSQTKDSAGFRATEAAWCSTFSGLETSQTGDLAGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7D0</accession>
    <name>A0A074Z7D0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596963">
        <property type="protein sequence ID" value="KER21487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174766.1">
        <property type="nucleotide sequence ID" value="XM_009176502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7D0"/>
    <dbReference type="GeneID" id="20324368"/>
    <dbReference type="KEGG" id="ovi:T265_10200"/>
    <dbReference type="CTD" id="20324368"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="118" mass="13465" checksum="3D050EBB607A977A" modified="2014-10-01" version="1">MWDPSKAPPAFFPSKQSLEFYPTQASELECDPNEVPMQMLRKTPNYGDSGACRIRLIHPTCSPNSSIKPDIFRSLPEFHPSKVVRISFRTLSEVLRMPRTSHSHRNRSSAKGYQCQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8Z4</accession>
    <name>A0A074Z8Z4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_09750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174184.1">
        <property type="nucleotide sequence ID" value="XM_009175920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8Z4"/>
    <dbReference type="STRING" id="6198.A0A074Z8Z4"/>
    <dbReference type="GeneID" id="20323918"/>
    <dbReference type="KEGG" id="ovi:T265_09750"/>
    <dbReference type="CTD" id="20323918"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER22062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="24338" checksum="CA207FB5B0566DAE" modified="2014-10-01" version="1">MVAGLKSVGYGMRLAMLDLPLECRRLRGDLILNCALFGPALASRFFTVDPESTRRGHKPSLKHYWALIYANPRAGEHAAPRCEHKERCLGNSPDPAGGKAGKDSGKAKAKAISRSHRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDTLIKATIAGGGVIPHIHKSLIGKKVPPQKPMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z989</accession>
    <name>A0A074Z989_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Legumain prodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_15453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597135">
        <property type="protein sequence ID" value="KER19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176447.1">
        <property type="nucleotide sequence ID" value="XM_009178183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z989"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20329618"/>
    <dbReference type="KEGG" id="ovi:T265_15453"/>
    <dbReference type="CTD" id="20329618"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Legumain prodomain" evidence="3">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="320" mass="36736" checksum="3095860DFC7058A3" modified="2014-10-01" version="1" fragment="single">DVKPDIFAKVLEGDKELEKQGKKVLKSGPEDNVFIYYSGHGAIAYISFPNGKLTATQLNDILVKMRSNKKYNKLVFYLDACYSGSMFLDILPSDAGVYVTTSTNEEELSYGTFCIDPRIAVCLATEYSYAWITDSEHKDLRKRTLNQQYVEVKKRTEQSHVMKYGDMTMGSLPVAMFQGHYHLLTHRNDEASNSNVVDRQLSSRTHLFSLTRRLMLATTEEEQEFTSRKLRRALQLGHVVKEAFHDIVMDVTTHRRLLVKDVSKRDELICYEAVYDHFETHCFKIQQVPEIAEHTVHLMELCKAGYEAQTLIESVHSVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA78</accession>
    <name>A0A074ZA78_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596825">
        <property type="protein sequence ID" value="KER24038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172209.1">
        <property type="nucleotide sequence ID" value="XM_009173945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA78"/>
    <dbReference type="STRING" id="6198.A0A074ZA78"/>
    <dbReference type="GeneID" id="20322389"/>
    <dbReference type="KEGG" id="ovi:T265_08210"/>
    <dbReference type="CTD" id="20322389"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="291" mass="32109" checksum="B0AD2E82F45FBDAC" modified="2014-10-01" version="1">MRIKNGFLKLKAVSGLEKVLNPSPNPDRSVLVCIKILRLPAHYRSTRCNEQSTGRTATLQQSLLSHLPFKSPVCESAHGDRPTQQHSYSDRGLDTRHHHRSTRDLSVGDVSSVDTGTTQQLPSPPPSSMQQQALALTAAAYATLDPMMAVHQQAKAYYDQWASSLFGNWASSGGAGGCGSSGQLSVNSEAHCSLQRQQQQQQQTDWINAALLSKQQQQLVNSQYEHGDPTENDNLRQWPWPINQRRVHASDDRTSTVTRKRVSAGQHLQGLHVPLALFHAETISGRILIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAK9</accession>
    <name>A0A074ZAK9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596821">
        <property type="protein sequence ID" value="KER24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172107.1">
        <property type="nucleotide sequence ID" value="XM_009173843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAK9"/>
    <dbReference type="STRING" id="6198.A0A074ZAK9"/>
    <dbReference type="GeneID" id="20322309"/>
    <dbReference type="KEGG" id="ovi:T265_08130"/>
    <dbReference type="CTD" id="20322309"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="70650" checksum="9EA36BAA4352A6FE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB92</accession>
    <name>A0A074ZB92_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171878.1">
        <property type="nucleotide sequence ID" value="XM_009173614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB92"/>
    <dbReference type="STRING" id="6198.A0A074ZB92"/>
    <dbReference type="GeneID" id="20322128"/>
    <dbReference type="KEGG" id="ovi:T265_07949"/>
    <dbReference type="CTD" id="20322128"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="431" mass="46311" checksum="F540892EAE90C246" modified="2014-10-01" version="1">MGRIFNRALLDNLTSSNLISPAAIVTLNPVLALCTITMALVNYDNSDNELSDSAEESTDDIVTETGVDKVEPEYKMRMPKSAARTANPATVVPALVTSKTKTGKVLLSVPALQELDSSSDESDNDRGAVTKQLGSAGQRSVGLLSLLPPTRAPVTRDGPKPLMMVPHQLAVKRPAPGHLVKRNQLGGAVGQAATQNGVSEDSRDSDVDDNDDADETEDSTSTSFFSFFQPAPESEQAVAEVRAATATSIIRAMASKADEPTGSDDTRQPGFEEQMIISSTSKQTPSKPIVQTPTSSLCRIDPAVLSELDVPKKEVPPDGDEAIGDVQCWTEHTFVPGPERKRARLNQPGTRSIPVHDLLATSNQSIREVNQADLTVGADLELMKSVTADESQYRSHRASEDDDPGKLAHRKHQITWLAYQASFFSSSCFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBN6</accession>
    <name>A0A074ZBN6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_14356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596800">
        <property type="protein sequence ID" value="KER24686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171560.1">
        <property type="nucleotide sequence ID" value="XM_009173296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBN6"/>
    <dbReference type="STRING" id="6198.A0A074ZBN6"/>
    <dbReference type="GeneID" id="20328522"/>
    <dbReference type="KEGG" id="ovi:T265_14356"/>
    <dbReference type="CTD" id="20328522"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="65"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="219" mass="24561" checksum="A8FF4B92F237DE18" modified="2014-10-01" version="1" fragment="single">MSFHAYLRKLSGGQGMGKYVTLENLSCKVRSGCQGHPPWPEGICTKCQPNPVTLEIQPYRHVDYVQFENGQLMETFLDYWRQTGEQRIGILLGRYAHFDTAGSPPLAIKAVVAAIYEPLQESTTRSVKLTAPLDALLPDHVAEVTKRLGLQPVGWIFTDLVAEDQPGKGAVKHYRGTMVSNQAMVLVRDNILVPTYDAPEFGYIRETTKDQFVPEVFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBY3</accession>
    <name>A0A074ZBY3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596865">
        <property type="protein sequence ID" value="KER23107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173165.1">
        <property type="nucleotide sequence ID" value="XM_009174901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBY3"/>
    <dbReference type="GeneID" id="20323137"/>
    <dbReference type="KEGG" id="ovi:T265_08958"/>
    <dbReference type="CTD" id="20323137"/>
    <dbReference type="OrthoDB" id="10543761at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="18127" checksum="07082EBEA1BF74CB" modified="2014-10-01" version="1">MDFFLKRIRTAPAIEHNIDSTIESECRSTSNDPPASGSADAIYCMNAITTIVLRCSGRKTPKVGFGSGSTRPHFGCTMILVSCQLHLIHCFWSPTILNGIDGDDKRALPFNALLPRPQSTPSTILVILPLDIRAYGERSDLSTCRFLPSPFLNGGLSFSSSLSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZC77</accession>
    <name>A0A074ZC77_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">T265_10713</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KL597018">
        <property type="protein sequence ID" value="KER20810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175434.1">
        <property type="nucleotide sequence ID" value="XM_009177170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZC77"/>
    <dbReference type="STRING" id="6198.A0A074ZC77"/>
    <dbReference type="GeneID" id="20324881"/>
    <dbReference type="KEGG" id="ovi:T265_10713"/>
    <dbReference type="CTD" id="20324881"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="274"/>
            <end position="297"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="911"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1062"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="845"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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            <position position="390"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        </location>
        <ligand>
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        </ligand>
    </feature>
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            <position position="472"/>
        </location>
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            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="569"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="649"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="651"/>
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            <name>ATP</name>
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        </ligand>
    </feature>
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            <position position="792"/>
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            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="819"/>
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    </feature>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00051303"/>
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            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER20810.1"/>
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    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
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    <sequence length="1200" mass="134683" checksum="D9C013C617EA4E66" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDK6</accession>
    <name>A0A074ZDK6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_08463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="KL596839">
        <property type="protein sequence ID" value="KER23697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172539.1">
        <property type="nucleotide sequence ID" value="XM_009174275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDK6"/>
    <dbReference type="STRING" id="6198.A0A074ZDK6"/>
    <dbReference type="GeneID" id="20322642"/>
    <dbReference type="KEGG" id="ovi:T265_08463"/>
    <dbReference type="CTD" id="20322642"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER23697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="454" mass="52472" checksum="9D0C2C0EC67C89A0" modified="2014-10-01" version="1">MVLQAVEKFSSWILFSKNGYLPVSCILLFAELALSLFVVWNVKCMFNSFQLFLDIAFQDTEIDWIAYMQEVEGFVNGTLDYDKLEGQTGPCVYVRRLYPAGFLYIYWMLYQITSRGTLIHLAQYIFIGLYLLTLVLVFNIYRLSCQVPPYVFVFMCVISYRIHSIYVLRLFNDPLAMIALYACVNFLLYGKFTLACIFFSLGVSVKMNILLFAPGLFLILLYYRGILETAGHLCECIIVQLVVGAPFLFHNYEAYISRAFNFGRQFMYKWTVNWRIIPEDVFLDRRFHAVLLGLHATFLIILLFKWVRYRGGFSEFLELQVPPDRDPRKDMSGVIYPMFISNFIGVTFSRSLHYQFYVWYFHTIPYLLWTTSLPSSPLKLLIFGLIEVCWNTYPSTVFSSGLLHACHGILLTSLVFAPLPTASFERVSSKVSIQPIPNKTTAPSKRRGGKAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZF76</accession>
    <name>A0A074ZF76_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170292.1">
        <property type="nucleotide sequence ID" value="XM_009172028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZF76"/>
    <dbReference type="STRING" id="6198.A0A074ZF76"/>
    <dbReference type="GeneID" id="20320873"/>
    <dbReference type="KEGG" id="ovi:T265_06694"/>
    <dbReference type="CTD" id="20320873"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8089" checksum="D6AD07B353E8007D" modified="2014-10-01" version="1" fragment="single">CPPPGVTPYSVQAGGPPPAVGFVVPTPAYTTVTVPQATVYVQQPTATTVTAVQFHRHPVTMTCPHCRYYGPTRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFP0</accession>
    <name>A0A074ZFP0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596809">
        <property type="protein sequence ID" value="KER24457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171797.1">
        <property type="nucleotide sequence ID" value="XM_009173533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFP0"/>
    <dbReference type="GeneID" id="20322062"/>
    <dbReference type="KEGG" id="ovi:T265_07883"/>
    <dbReference type="CTD" id="20322062"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7223" checksum="DA1170ED2EE14718" modified="2014-10-01" version="1">MVLHGHQWFASDVSKSGIKRVIVKISRRRPSPTCEVSKGLRTRLLEKQMSNFIGCINRAQVANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGL5</accession>
    <name>A0A074ZGL5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169838.1">
        <property type="nucleotide sequence ID" value="XM_009171574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGL5"/>
    <dbReference type="GeneID" id="20320523"/>
    <dbReference type="KEGG" id="ovi:T265_06341"/>
    <dbReference type="CTD" id="20320523"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="457" mass="51219" checksum="036EDBBB5D123D2F" modified="2014-10-01" version="1">MTGFALLGANQKAPVAELLTRKHQLNSYRVLNREAKLSYASCLQKLNIHPLCERVLRNFYGYQWRCSGRENFQTHSAGRMLLSRVWLPDRRFMEFEGLSGFRVIWNNLQEFDLSDSGYHCIERIPHLVQGGKMAQWLVREFGDRKDCGSNPTSASLLPLSMLGQPGNVPSLVLPSFRPSWGVSGGRSSRVSEKPCVLLEPKLQEVSEIQSFANKSGYSGDSPGTKLICPEASNPNNRTARRLDGCVTCGLRAKRRHVLIGQNTSQSESSIFSLTLLAPPREILARPCGAFSVKLSRCLAAILTEEGTRAGISPGCSTLDEGSRDAEQMNVLYQTASFFSPYDIRDVVIHVLHGALIQQKTVEKVKGQLQPTNWSISREIHTHLQINLVFTRDQTEPLVYDVLQLNVLHTGRLMIQLARYSRYRKNKIGWEANLMLTYHHHPDVPTPPGSYSGSLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGW9</accession>
    <name>A0A074ZGW9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596747">
        <property type="protein sequence ID" value="KER26448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169795.1">
        <property type="nucleotide sequence ID" value="XM_009171531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGW9"/>
    <dbReference type="GeneID" id="20320486"/>
    <dbReference type="KEGG" id="ovi:T265_06304"/>
    <dbReference type="CTD" id="20320486"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9078" checksum="DD7F3DCF40F83117" modified="2014-10-01" version="1">MNGWLDLCTNLSAPACNAQLLTPLPKSSVNETAAATTTVRQGRMYTATILSILFCELETYSLCAEDVRKLFILDHWGLRSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH73</accession>
    <name>A0A074ZH73_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169593.1">
        <property type="nucleotide sequence ID" value="XM_009171329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH73"/>
    <dbReference type="GeneID" id="20320318"/>
    <dbReference type="KEGG" id="ovi:T265_06136"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705240" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15234" checksum="B671DC6E00FC2EA2" modified="2014-10-01" version="1">MDNCYLCVLLLVVISGNIVDGLYRANLPPANQKRALPNVFESENHLNPSYETDVYAMFVPPIRKTVQHIATIPDEYERIPPEQNGPASGDFGNLVKVEDLDRKQMLRYPWEEAVERSHHLDDVEPILSPIQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH78</accession>
    <name>A0A074ZH78_OPIVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171334.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20320323"/>
    <dbReference type="KEGG" id="ovi:T265_06141"/>
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    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="226" mass="24830" checksum="CE870ECE2A43FA88" modified="2014-10-01" version="1">MAYVDLHHILKDHAPRKYILVGRKLTLQAGTGFALLVAILPEESTRAGTLSGSPSLDRESREAEVGSEPRTFRTNAAAVVANPACAASGFNNSDDIRVSCTLEMSGLKVVEHLDVYELDLKIFQQQKSEQLTLQFSAADQHCGYLPLKQDISSPILQSRKPPRGYILSDFASDDFSYRMAWCLLSGAPKSCGADAKTIQCYFSDNLQALLDKCTVDSSDYTQFPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIX7</accession>
    <name>A0A074ZIX7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER27283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009170668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIX7"/>
    <dbReference type="GeneID" id="20319791"/>
    <dbReference type="KEGG" id="ovi:T265_05609"/>
    <dbReference type="CTD" id="20319791"/>
    <dbReference type="OrthoDB" id="8043115at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="KER27283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9164" checksum="C6F347C3BBCF0B6F" modified="2014-10-01" version="1">MQCTPREAIKGTPITFEMIRKATIEEPLLSQVEKYHLSKWSQNGTGYAKFPDSCTTAFVQDVLSLVWSTAKEQGKFFGSCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIY2</accession>
    <name>A0A074ZIY2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_05614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER27288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009170673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIY2"/>
    <dbReference type="STRING" id="6198.A0A074ZIY2"/>
    <dbReference type="GeneID" id="20319796"/>
    <dbReference type="KEGG" id="ovi:T265_05614"/>
    <dbReference type="CTD" id="20319796"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF161">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="618"/>
        </location>
    </feature>
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        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER27288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="834" mass="96430" checksum="B1CF5FCFF542E218" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJ72</accession>
    <name>A0A074ZJ72_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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        <lineage>
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            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596765">
        <property type="protein sequence ID" value="KER25817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170440.1">
        <property type="nucleotide sequence ID" value="XM_009172176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJ72"/>
    <dbReference type="GeneID" id="20328301"/>
    <dbReference type="KEGG" id="ovi:T265_14135"/>
    <dbReference type="CTD" id="20328301"/>
    <dbReference type="OrthoDB" id="6272346at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="247" mass="28295" checksum="B42A76C93B857C10" modified="2014-10-01" version="1" fragment="single">MPQQEQSEHVSTESEQIATCIKRILDSIRCIKPQLVCFYRSINLEALGLQIKQLCSLLRSDSNSRAVKQEKTDHSPPPGQDYLLGVCRTKPPIKKPTVYKIIHSTRYDSGKAHKTYGRAKLNMGDNITQENIQGVVNYATAIRVDITHATKMLCVLEDLIRMLDHKYCKRGKPDIKVASQKDVQVSSNSGEISQVRRTFGSLSECVSRINSRRHMDRILIHLRRRSTANSLIYLIDQERHKKSPWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKK0</accession>
    <name>A0A074ZKK0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168646.1">
        <property type="nucleotide sequence ID" value="XM_009170382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKK0"/>
    <dbReference type="GeneID" id="20319566"/>
    <dbReference type="KEGG" id="ovi:T265_05384"/>
    <dbReference type="CTD" id="20319566"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="312" mass="33588" checksum="0DF8C1EED586FFF4" modified="2014-10-01" version="1">MPGTSEPITTGTIQTTIDRRGDWNPTAGSATLRPKETGATSEIELAYKTSGPTSLTDIEVTLGQEKFWGDGRPAMQKTARDKSNTNDILDAPRHGKSTCAESDAPPRSPSVRRVRKVACTGTLFCATNGDSVNAAGGQQDRRKVEESELAGQRGRPRQLGQAAAINVPSMVLEDSNSSLQVDPKSCLRTSQTRDSARFQTKSSTTSISSPASMGFGFDPNQSYVIFITSMAQQSCSGAQSKKSYIILRGQTPREDFGAVSGADEEESRSTSNSKQGRKDGRGQTRLTSVEVMNLEGLLRQMYVHESKLTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLF8</accession>
    <name>A0A074ZLF8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_08111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172082.1">
        <property type="nucleotide sequence ID" value="XM_009173818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLF8"/>
    <dbReference type="STRING" id="6198.A0A074ZLF8"/>
    <dbReference type="GeneID" id="20322290"/>
    <dbReference type="KEGG" id="ovi:T265_08111"/>
    <dbReference type="CTD" id="20322290"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015701">
        <property type="term" value="P:bicarbonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF47">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="263"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="459"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="814"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115816" checksum="7D758257DB233DD6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLU1</accession>
    <name>A0A074ZLU1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168189.1">
        <property type="nucleotide sequence ID" value="XM_009169925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLU1"/>
    <dbReference type="STRING" id="6198.A0A074ZLU1"/>
    <dbReference type="GeneID" id="20319207"/>
    <dbReference type="KEGG" id="ovi:T265_05025"/>
    <dbReference type="CTD" id="20319207"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000133">
        <property type="entry name" value="Protein CBR-PPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF510">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER28041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="305" mass="34999" checksum="84F9EFE8B6B900D4" modified="2014-10-01" version="1">MVQEFNIDAFIERLLEGTFLLSLDHLICLLVRCGRPGTLVEMKEDEIRYICEKSREIFLAQPILLELEAPLQICGDIHGQYTDLLRLFEHGGFPPASNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFLLRGNHECAAINRIYGFYDECLSPDLQNMEQIRRILRPSDIPDTGLLCDLLWSDPDKDVTGWAENDRGVSFTFGPDVVSKFLNRHDLDLICRAHQVVEDGFEFFHRRQLVTLFSAPNYCGEFDNAGGMMTVDENLTCSFQVLKPSEKKAKYQYHGMTPVTQQQPAARVAQPRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLX4</accession>
    <name>A0A074ZLX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mss4 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_14444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596813">
        <property type="protein sequence ID" value="KER24365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171906.1">
        <property type="nucleotide sequence ID" value="XM_009173642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLX4"/>
    <dbReference type="STRING" id="6198.A0A074ZLX4"/>
    <dbReference type="GeneID" id="20328610"/>
    <dbReference type="KEGG" id="ovi:T265_14444"/>
    <dbReference type="CTD" id="20328610"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER24365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23800" checksum="EF4355FC5519A732" modified="2014-10-01" version="1" fragment="single">VAPKSGGSTDLITGEGTNVFDVCCPRCGSVVLRKNSAKLIERQCISVLKRHRAAGPDDLPPVLFYDDGYWGEWRNVPIFKKGIRGECNDNTSVSLTPVVTRLPASPILRRHTAARESLTDDHRQSIPVYAKKSELSNPSNEFPTDMITQFWAVHDMYTFENVGFTHSVNAIRYLTCADCELGPIGFQDMAECQPAAYYVALSRTCHRGQSAGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM71</accession>
    <name>A0A074ZM71_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoacetylglucosamine mutase</fullName>
            <ecNumber evidence="5">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="5"/>
    <dbReference type="EMBL" id="KL596809">
        <property type="protein sequence ID" value="KER24470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171815.1">
        <property type="nucleotide sequence ID" value="XM_009173551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM71"/>
    <dbReference type="STRING" id="6198.A0A074ZM71"/>
    <dbReference type="GeneID" id="20328589"/>
    <dbReference type="KEGG" id="ovi:T265_14423"/>
    <dbReference type="CTD" id="20328589"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="118"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="14">
        <location>
            <begin position="209"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="13">
        <location>
            <begin position="332"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="11">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER24470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="714" mass="77840" checksum="B909BC6B393B56F1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM98</accession>
    <name>A0A074ZM98_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596697">
        <property type="protein sequence ID" value="KER28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167710.1">
        <property type="nucleotide sequence ID" value="XM_009169446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM98"/>
    <dbReference type="GeneID" id="20318837"/>
    <dbReference type="KEGG" id="ovi:T265_04655"/>
    <dbReference type="CTD" id="20318837"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="9749" checksum="ADB30590457C255D" modified="2014-10-01" version="1">MCTSSNCSSGWRRSVYVDSISAPGTLKIGAPIAFTGGRHYPGNTVGTTVCPPLWPNMTQSGMLNSKPPIVMLSRIVSLMCVQGGNHLVGDAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMY1</accession>
    <name>A0A074ZMY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171583.1">
        <property type="nucleotide sequence ID" value="XM_009173319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMY1"/>
    <dbReference type="GeneID" id="20321902"/>
    <dbReference type="KEGG" id="ovi:T265_07723"/>
    <dbReference type="CTD" id="20321902"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="14601" checksum="31248AF882692EBA" modified="2014-10-01" version="1">MCIVFWHKPHFSRIRMPSLKQTFATLRTNVQPSSELFTENMKISISILFILPVPRCHAIRRKHDGWDTARLSKPRQEQFRLSSNLRSSGQKDEKQVGSDLVLNYDSHSKVSKPPDTHSEKLSRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP57</accession>
    <name>A0A074ZP57_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167096.1">
        <property type="nucleotide sequence ID" value="XM_009168832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP57"/>
    <dbReference type="GeneID" id="20318348"/>
    <dbReference type="KEGG" id="ovi:T265_04162"/>
    <dbReference type="CTD" id="20318348"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25843" checksum="8CA7B3CDA3D0D0C2" modified="2014-10-01" version="1">MTGTGYAVTLLREGRFHKSADGCTVRKCNTILLRGPAGIIVVNPGSVWDASALHESLKSIGVSPEAVNCVICTDGRAEHVGCISLFSNAEMMIVGYDIQKRGDIFLEHDFGDGIVPYEFDEYLYVIGTPGQRGQQVSLMVRGWITDGMEQDVPPTGRIAITGNLFTDKDDASSVSIFDTFEGNLDETMGDTETHVNYWRRSRQYVLDRADWIIPAFGACFKVQPEFSSTPCVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP61</accession>
    <name>A0A074ZP61_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167117.1">
        <property type="nucleotide sequence ID" value="XM_009168853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP61"/>
    <dbReference type="GeneID" id="20327603"/>
    <dbReference type="KEGG" id="ovi:T265_13436"/>
    <dbReference type="CTD" id="20327603"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="133" mass="15007" checksum="5BEB8BB86C602966" modified="2014-10-01" version="1">MCFELHVWIFSYVCLFCLFFFQSILLPFSNVDQLDFQFVLAFAIAFASDCLFAQQYLLYKSGVIMTSQVGFQILIAFYARNFRELDAGSPSLYVCSAFSCKLEFLSLPNSTSSCALLIVLLIDLVSIPNSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZPC4</accession>
    <name>A0A074ZPC4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167021.1">
        <property type="nucleotide sequence ID" value="XM_009168757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZPC4"/>
    <dbReference type="GeneID" id="20318297"/>
    <dbReference type="KEGG" id="ovi:T265_04111"/>
    <dbReference type="CTD" id="20318297"/>
    <dbReference type="OrthoDB" id="10500157at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13309" checksum="BDFE5E7190F52C60" modified="2014-10-01" version="1">MHLRVGPMVTLGMPHSLHMPPHDSDGTIFEISQYIFINEATHKCTEISSTAHNRFCPSWGSSDRRSRRVSFNYLNPNWTVFEKHTHLQINLVFTADSTEPLVYNILQLNVLGLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ27</accession>
    <name>A0A074ZQ27_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vinculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_03834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596676">
        <property type="protein sequence ID" value="KER29528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166679.1">
        <property type="nucleotide sequence ID" value="XM_009168415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ27"/>
    <dbReference type="STRING" id="6198.A0A074ZQ27"/>
    <dbReference type="GeneID" id="20318021"/>
    <dbReference type="KEGG" id="ovi:T265_03834"/>
    <dbReference type="CTD" id="20318021"/>
    <dbReference type="OrthoDB" id="29742at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017997">
        <property type="entry name" value="Vinculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46180">
        <property type="entry name" value="VINCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00664">
        <property type="entry name" value="VINCULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER29528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="801" mass="88638" checksum="7EB22B6E28D61F96" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQ29</accession>
    <name>A0A074ZQ29_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167037.1">
        <property type="nucleotide sequence ID" value="XM_009168773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQ29"/>
    <dbReference type="GeneID" id="20318301"/>
    <dbReference type="KEGG" id="ovi:T265_04115"/>
    <dbReference type="CTD" id="20318301"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="81" mass="9477" checksum="F94C1923050621B8" modified="2014-10-01" version="1">MLFYLERIRFKEVDIGLNCIRLIRKFLEVGTPKNAKICYSAILCFMSRKPAENPNRRWSTTLEFRSLKQSATCNMSREGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQI8</accession>
    <name>A0A074ZQI8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_04998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168152.1">
        <property type="nucleotide sequence ID" value="XM_009169888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQI8"/>
    <dbReference type="STRING" id="6198.A0A074ZQI8"/>
    <dbReference type="GeneID" id="20319180"/>
    <dbReference type="KEGG" id="ovi:T265_04998"/>
    <dbReference type="CTD" id="20319180"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705323" description="Receptor ligand binding region domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="65"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER28087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="509" mass="56882" checksum="20BE82BBD4BFF7A9" modified="2014-10-01" version="1">MPVHGRSSRLIVFSLCLYLCFGVDTRTTLFVDSPGDIMLGGLFPVHTTGTTNCNVINPERGIQRVEAMLFTIDEINNDTKLLPGLRLGAIIRDTCSASQFALEQALHFVLSSTDKCPADRGESSGEKRGLNKDTPITRGVVGSSYSSVSILVANLFRLFSIPQISYASTSAVLSDKRAFPLFARTVPSDVVQARAMATLVHDHNWTYVSTVRSAGDYGDSGMDAFWKEADKLGVCIAAREVIRINSGTEDLDAIVRVLRYDFAKARVVVLFTGMDHTKLLLDAVQRAGLVDHFVWIASDGWGRENLPVANNSRVANGALTIEIQAKPVTEFTEHYLNLGYDNPRNPWFRKYWEELFDCTFDTDATASKQRGRRSLQTSAYRSVQRRSATESRTKPCSRDRNQRLRDRLSSGFQQEAKVQFVYNAVYAFAHGLHKLQEQLCPGNPYHPSWDKYMCIERLLNFSGTEFYETMISTSFTADNDDDDNGDDDGDDDDDDDDNDDDDQDSNPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZQK5</accession>
    <name>A0A074ZQK5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_03984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166855.1">
        <property type="nucleotide sequence ID" value="XM_009168591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZQK5"/>
    <dbReference type="STRING" id="6198.A0A074ZQK5"/>
    <dbReference type="GeneID" id="20318170"/>
    <dbReference type="KEGG" id="ovi:T265_03984"/>
    <dbReference type="CTD" id="20318170"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="70"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER29416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="325" mass="38045" checksum="ECD5243258037812" modified="2014-10-01" version="1">MNKRVTFSPQNEEPAKPAETQPRKTKLRRTHSTFKNKVMPQLLENHRRMLEHRECSIPCIFESHSKVLLLWTTVVSGAIIYNLWLPILRQSFGGVQRTYLWLWIVLDLLADVIYILDILVRTRCTYLDTGLIVSDRKRTTDHYIKTRLFLLDVLSLLPTDFLQFKIGMHPMIRFPRFLKVYRALQWRTKIRTLSKIPNAWRVVGLIHLLFLGCHWFACIYYDISVYEEFSTRWCYSPNPSLNYSLGQSYLESFYWATLALTCIGIHEAPTNAVDDANGFLHAQRCVFHIFDFSHSGPPREPNCHLLKIEGGICMLVWHVTLDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRK2</accession>
    <name>A0A074ZRK2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166174.1">
        <property type="nucleotide sequence ID" value="XM_009167910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRK2"/>
    <dbReference type="GeneID" id="20317613"/>
    <dbReference type="KEGG" id="ovi:T265_03426"/>
    <dbReference type="CTD" id="20317613"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="17077" checksum="DE1EE0FDCD2283C7" modified="2014-10-01" version="1">MIFEISQYIFLRETTHKVAENSSTAHDQFRPSWGSSGRRSPGVSANFMFYLNPSVGSNDMFPLGTTRGYTASVTDLNELIIDCEVKYSTLIRLEPSYIPRGSRVLWMRNLPKIAGFQRTRNYSNKASRLDMGSQLLWTSEESFPDKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS24</accession>
    <name>A0A074ZS24_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596665">
        <property type="protein sequence ID" value="KER30188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166067.1">
        <property type="nucleotide sequence ID" value="XM_009167803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS24"/>
    <dbReference type="GeneID" id="20317529"/>
    <dbReference type="KEGG" id="ovi:T265_03342"/>
    <dbReference type="CTD" id="20317529"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="180" mass="20307" checksum="6D66294A68C7CF91" modified="2014-10-01" version="1">MTSQGEIKVVETGLNAVGSSRLSGWGHVAEKLAQVGRRCWENLSMARYSDTMLRYVSVGDEMAQWLERLSTNRKIRCSNPTSTSRLLLSRFEQPGSIPAFVLPSGGMHVDPRFQVTEFLKEVEIHLEIAGSGELLDVIHARYHGPHKQMLAHMVVRLYTRTSPSSLKYAMYRLSGRVMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSK2</accession>
    <name>A0A074ZSK2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596750">
        <property type="protein sequence ID" value="KER26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169903.1">
        <property type="nucleotide sequence ID" value="XM_009171639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSK2"/>
    <dbReference type="STRING" id="6198.A0A074ZSK2"/>
    <dbReference type="GeneID" id="20320570"/>
    <dbReference type="KEGG" id="ovi:T265_06391"/>
    <dbReference type="CTD" id="20320570"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF289">
        <property type="entry name" value="ETS-LIKE PROTEIN POINTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="578"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="726" mass="81494" checksum="828BEE3BB67A950C" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSK5</accession>
    <name>A0A074ZSK5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL605232">
        <property type="protein sequence ID" value="KER18249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178004.1">
        <property type="nucleotide sequence ID" value="XM_009179740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSK5"/>
    <dbReference type="STRING" id="6198.A0A074ZSK5"/>
    <dbReference type="GeneID" id="20330355"/>
    <dbReference type="KEGG" id="ovi:T265_16190"/>
    <dbReference type="CTD" id="20330355"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="44" mass="4987" checksum="C44AD1F3812FE8F6" modified="2014-10-01" version="1" fragment="single">MELAIGRYPIPTVDAVDFVRTFAPDLESNMIEHWRAAKTGEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT12</accession>
    <name>A0A074ZT12_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596745">
        <property type="protein sequence ID" value="KER26520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169713.1">
        <property type="nucleotide sequence ID" value="XM_009171449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT12"/>
    <dbReference type="GeneID" id="20320421"/>
    <dbReference type="KEGG" id="ovi:T265_06239"/>
    <dbReference type="CTD" id="20320421"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="64" mass="7738" checksum="75C93FE2EB0EF31B" modified="2014-10-01" version="1">MDFKYVDVGRVQIESTCHKSRRWRRDEKLVKKLDIRMKERTINPTSNAVEPTRRSITVCWTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTK8</accession>
    <name>A0A074ZTK8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">T265_06075</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169517.1">
        <property type="nucleotide sequence ID" value="XM_009171253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTK8"/>
    <dbReference type="STRING" id="6198.A0A074ZTK8"/>
    <dbReference type="GeneID" id="20320257"/>
    <dbReference type="KEGG" id="ovi:T265_06075"/>
    <dbReference type="CTD" id="20320257"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704282" description="Peptidase metallopeptidase domain-containing protein" evidence="17">
        <location>
            <begin position="24"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="18">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="480"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="534"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KER26710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="591" mass="67179" checksum="FF21F438508ED0BE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTL1</accession>
    <name>A0A074ZTL1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596740">
        <property type="protein sequence ID" value="KER26715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169520.1">
        <property type="nucleotide sequence ID" value="XM_009171256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTL1"/>
    <dbReference type="GeneID" id="20320260"/>
    <dbReference type="KEGG" id="ovi:T265_06078"/>
    <dbReference type="CTD" id="20320260"/>
    <dbReference type="OrthoDB" id="6236692at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="16600" checksum="6D14613DE801CE16" modified="2014-10-01" version="1">MLSDIILQENVIPPAVRKPQIEAPREIAPKKTFGLRDPNVVTRPLNPLNLTTSKSTSTEVSQKTQSSLDDSIEQYHPPSAADDYADIFQYTGRLDELLSGVTNLIAHQAELSPNPTSSNNVYSNDEDDTLEEDLYLPDELLASLYPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZU80</accession>
    <name>A0A074ZU80_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_03967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166838.1">
        <property type="nucleotide sequence ID" value="XM_009168574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZU80"/>
    <dbReference type="STRING" id="6198.A0A074ZU80"/>
    <dbReference type="GeneID" id="20318153"/>
    <dbReference type="KEGG" id="ovi:T265_03967"/>
    <dbReference type="CTD" id="20318153"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER29397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="649" mass="73120" checksum="50B6788368531DD2" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVC6</accession>
    <name>A0A074ZVC6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596651">
        <property type="protein sequence ID" value="KER31086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165209.1">
        <property type="nucleotide sequence ID" value="XM_009166945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVC6"/>
    <dbReference type="GeneID" id="20316835"/>
    <dbReference type="KEGG" id="ovi:T265_02647"/>
    <dbReference type="CTD" id="20316835"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7514" checksum="F74A62CEFCF3488E" modified="2014-10-01" version="1">MYVVCQKQGCRIELTAPRSLPGSECAPMTAATGYVRVGIVLSDRAEASLMDWILLDSRLCGVGALAVSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVE1</accession>
    <name>A0A074ZVE1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_02342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596646">
        <property type="protein sequence ID" value="KER31433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164820.1">
        <property type="nucleotide sequence ID" value="XM_009166556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVE1"/>
    <dbReference type="STRING" id="6198.A0A074ZVE1"/>
    <dbReference type="GeneID" id="20316530"/>
    <dbReference type="KEGG" id="ovi:T265_02342"/>
    <dbReference type="CTD" id="20316530"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000026">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="240"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER31433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131318" checksum="1B0590CAA9219C75" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVX0</accession>
    <name>A0A074ZVX0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596648">
        <property type="protein sequence ID" value="KER31251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164957.1">
        <property type="nucleotide sequence ID" value="XM_009166693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVX0"/>
    <dbReference type="GeneID" id="20316632"/>
    <dbReference type="KEGG" id="ovi:T265_02444"/>
    <dbReference type="CTD" id="20316632"/>
    <dbReference type="OrthoDB" id="10062389at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47080" checksum="F6901622E46A01F5" modified="2014-10-01" version="1">MNNIPFVASTVVAEERVQSIAAPFAVELLYKLTATMRSKLFCFKSRDPRRDTPRTVYRTTNLNPNTLGKVQWGVTVWCASMTVINPHQMFSHHSLQVIIIIDSMTSAFNTDASLPYNQTENKNATDICRQPYLVVSPTRHSEDHAIPILEGCLKTSHFRCSNRPSLTTIQQKQPALCLKLANAVRALQICAFTSSVTLQSKRVQTPTYVKRSTTAITYPWIACVVFSDCTSTSMTLCLVGAKCIPKEGMNPETLQRSSHDFIDHEVEKEWREWVSLTATTLCTEALGELSVHTHTPKSLRIQRTYYVYKRPRHSLLEEGDLPSAWKVAVVTPIYKNADRLSPGSYWPISLTGVRASPAAPQSVPIREIIPMGNRLDFSSPAPVSVGVPQGSVLRPLLFLIYFHDFPNVPASSGLPFADDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW05</accession>
    <name>A0A074ZW05_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164583.1">
        <property type="nucleotide sequence ID" value="XM_009166319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW05"/>
    <dbReference type="GeneID" id="20316333"/>
    <dbReference type="KEGG" id="ovi:T265_02145"/>
    <dbReference type="CTD" id="20316333"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6966" checksum="C29D893653F752E6" modified="2014-10-01" version="1">MHTDSHNETKPWGKWAIDVLVLMDSLVLRVKPEPKKLRKPVIDTADGAEHHHTDISPFTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWG6</accession>
    <name>A0A074ZWG6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596664">
        <property type="protein sequence ID" value="KER30227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165996.1">
        <property type="nucleotide sequence ID" value="XM_009167732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWG6"/>
    <dbReference type="GeneID" id="20317473"/>
    <dbReference type="KEGG" id="ovi:T265_03286"/>
    <dbReference type="CTD" id="20317473"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="119" mass="13529" checksum="3E19837D35CBF95D" modified="2014-10-01" version="1">MLESTRQELTVYRQQDAPVYQTSSRFSEKTTMPPEGSTKAWIPPSCPSLDSRSRDAEAGFEPRTFRLANSRSNQKFNVEFNGTDVVIYPTTRQQININSIFKIKDPNTCRKLHTIVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX24</accession>
    <name>A0A074ZX24_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168378.1">
        <property type="nucleotide sequence ID" value="XM_009170114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX24"/>
    <dbReference type="GeneID" id="20319364"/>
    <dbReference type="KEGG" id="ovi:T265_05182"/>
    <dbReference type="CTD" id="20319364"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8279" checksum="E522199E419B4835" modified="2014-10-01" version="1">MSIARIDHKVKISTAFVDKPPFERIGFWGFARNSMWFNGLLELIYSTQIRKSNLKYPMDLRRSAQLESGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX72</accession>
    <name>A0A074ZX72_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597140">
        <property type="protein sequence ID" value="KER19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176473.1">
        <property type="nucleotide sequence ID" value="XM_009178209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX72"/>
    <dbReference type="GeneID" id="20325698"/>
    <dbReference type="KEGG" id="ovi:T265_11530"/>
    <dbReference type="CTD" id="20325698"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11369" checksum="0238211B0D665FAB" modified="2014-10-01" version="1">MRHQYSRSSWALRQLWSIYIEKKRILELSTRFLASSRKPNSPPTFSPSFSGMRKLANTCYMNSVLRAHPAANFVMSHTFFRYSAIRQEVSISEHDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZX99</accession>
    <name>A0A074ZX99_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_11507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597134">
        <property type="protein sequence ID" value="KER19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176443.1">
        <property type="nucleotide sequence ID" value="XM_009178179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZX99"/>
    <dbReference type="STRING" id="6198.A0A074ZX99"/>
    <dbReference type="GeneID" id="20325675"/>
    <dbReference type="KEGG" id="ovi:T265_11507"/>
    <dbReference type="CTD" id="20325675"/>
    <dbReference type="OrthoDB" id="2136082at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="511" mass="58043" checksum="BD141C7AFEEF5D3A" modified="2014-10-01" version="1">MFSFFPLIYAARSHSAEAFLPYGSRLRQKTLMRRTVTTPNLHRSTVPSARSTVRSATTRKHGKPTIQQRPKTQGGKSFSNIPSNIPEEQFAYLSTSNHLRRLLFNEPVCSPRQSASFSVKEKAVEDLSEEICLLKKKIAYQNAENQALTARCRQLNDSLAKKEKELAQLNDPAENAKLLQTLGDNRPQTMRTFRLLHQRIYRLEQRLQEKESEYNRLVTDMKFTRIDELQIQLEATIAEVRRLQKENITLSENLRQLTTERQSKSRKTVDDSERRDLLTRISTMGRVIKGLNDEKQELVSKNQHLLIRVQQILRNDDFPNDDIEQVTDNAPKKKKALFATKVNEDMVAQPESIQRKFETPGSRVNGDAATPVGNFDSSPVPEQSISRTAQIPVSEKEEHSAVIIQHAWRAHKKLHSSKLQEIQGNEEMTKVESEDISAIQTSGNPTNQTKEGKDGESEASTFITDEEEVLPGIPYTQSSAENGLHTGGRRSFSSVQTLEVDEEFESDESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYN5</accession>
    <name>A0A074ZYN5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_04749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KL596699">
        <property type="protein sequence ID" value="KER28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167826.1">
        <property type="nucleotide sequence ID" value="XM_009169562.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZYN5"/>
    <dbReference type="GeneID" id="20318931"/>
    <dbReference type="KEGG" id="ovi:T265_04749"/>
    <dbReference type="CTD" id="20318931"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="475"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="757"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1392" mass="158548" checksum="55D46194C003A8E9" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYS7</accession>
    <name>A0A074ZYS7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596698">
        <property type="protein sequence ID" value="KER28485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167777.1">
        <property type="nucleotide sequence ID" value="XM_009169513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYS7"/>
    <dbReference type="GeneID" id="20318891"/>
    <dbReference type="KEGG" id="ovi:T265_04709"/>
    <dbReference type="CTD" id="20318891"/>
    <dbReference type="OrthoDB" id="6263150at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22852" checksum="ACE2A4355466700C" modified="2014-10-01" version="1">MQFGFWENSTEVASVVVSIWCLATRSDRLYNSASLLSELNEEYWRRRRFSNCEVLEQEETGVFTLAITVDREKLRPEHQNLPRDFYLWVLNRQLNLQEIGCATLAGEIQNVGARLTFPSKWCMCEKLQSRKFENGLRIEKCILLDRVTEPLHTEYVATYEVKFDHPVSRGDAVRLLGDLNGGRKRCRFNMVPLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZE8</accession>
    <name>A0A074ZZE8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_04594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167633.1">
        <property type="nucleotide sequence ID" value="XM_009169369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZE8"/>
    <dbReference type="GeneID" id="20318776"/>
    <dbReference type="KEGG" id="ovi:T265_04594"/>
    <dbReference type="CTD" id="20318776"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705571" evidence="2">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="127" mass="13842" checksum="EA54722C7FD326F6" modified="2014-10-01" version="1">MYIYLLLLQLLRCCLTITSINLCCLICVGVVHAALCCTLLTSSTCLNCVYIMSLLPQSAWFHACIVGRVSLVPFHFLSLILACLLQCMFSMFGSPLVGISFTLPPELVHTVQRTAQHNSLVCSGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZZS5</accession>
    <name>A0A074ZZS5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596645">
        <property type="protein sequence ID" value="KER31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164782.1">
        <property type="nucleotide sequence ID" value="XM_009166518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZZS5"/>
    <dbReference type="GeneID" id="20327137"/>
    <dbReference type="KEGG" id="ovi:T265_12969"/>
    <dbReference type="CTD" id="20327137"/>
    <dbReference type="OrthoDB" id="10422970at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="396" mass="44967" checksum="519D275C08A71D1F" modified="2014-10-01" version="1" fragment="single">ILSTLKKVGVDKAVWNLVSDDFESVPVNWNISFDFGVIKQITGEDNLEKLKDILVQKLNGVDRSYTIQVAKKDIKLTFTNKVCGVLLIKPEAAAPLCQLRQNTLKHPPGFLIFKRFNMNGAQDLRQKVGLESSTSGTFCDMVNSLFAQQILWYSEHYQGCRPLDGLTEIPSLIASINFDYAGLGGVSLHESCFQMLSNIMNSILQTTTDGKVVNETAFNARGVTIFMIHVRLFAFYQMSAGPLVELEICFKLFCFHHMGYSDSMGFVETPTEYFFPYILRMEKVQVSGQIMDPIRWNFEPERFSPYYEQARTYTAQSLSKSLGNMGLLDSALTMKPEAFRIQDELRGLVGDVRLLFDLFSLGIELKTKEPRIILSTLKSRMQMPEKINEAYIFHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0I7</accession>
    <name>A0A075A0I7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596630">
        <property type="protein sequence ID" value="KER32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163387.1">
        <property type="nucleotide sequence ID" value="XM_009165123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0I7"/>
    <dbReference type="STRING" id="6198.A0A075A0I7"/>
    <dbReference type="GeneID" id="20315350"/>
    <dbReference type="KEGG" id="ovi:T265_01162"/>
    <dbReference type="CTD" id="20315350"/>
    <dbReference type="OrthoDB" id="5853681at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="9"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="416" mass="47387" checksum="5E58DA60112ED536" modified="2014-10-01" version="1">MLNHWKDFYYGLIGIGTPSKEFRLLFDTGSTVLWVHNRNAQHDLRPFKNIFDPKRSSSFVDDKTGFTAIYSNFAVRGFVGTDIFKLGDQSFKGKFSPVLLFRGEPRQYDWIDGILGLGRRQAYPAFRTTFLDQLLEQGLISRRTFAFVFCKHPLKTGAVIFGEITKDHIPGEVKYVKPSKTETFPNHWVIPIDWSNHTGLFVLPSLFDAHVKHGWTYGSTQINITERQRNTLICKLIWFFKRLTWNPAESLGCDVSRQNRASAIHTYSGASATIALSTDETLATGLNALVDTGTPITYLPADATTQLYALIGVTKYGNRNVVACDRIPSMPTLRFNFGGFELLLEPRQYIFVLIRLLKIHRQPTTGFAQFGAHQASVVSGFRQPYVLLETKLHEISEYTLICKPIWFFRETHLEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A2U3</accession>
    <name>A0A075A2U3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_10054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596948">
        <property type="protein sequence ID" value="KER21684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174572.1">
        <property type="nucleotide sequence ID" value="XM_009176308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A2U3"/>
    <dbReference type="GeneID" id="20324222"/>
    <dbReference type="KEGG" id="ovi:T265_10054"/>
    <dbReference type="CTD" id="20324222"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10109" checksum="BDF31AF2D0235B46" modified="2014-10-01" version="1">MRSLITLARAARLIPAGIGKTDQAVPQGPIKELGSGSGIPCAETFRLARTLLLTVINGQRGSDLDLPETNSNAAHRKGPFSHAEVTIEQEEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A4H5</accession>
    <name>A0A075A4H5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-CoA C-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596906">
        <property type="protein sequence ID" value="KER22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173926.1">
        <property type="nucleotide sequence ID" value="XM_009175662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A4H5"/>
    <dbReference type="STRING" id="6198.A0A075A4H5"/>
    <dbReference type="GeneID" id="20329050"/>
    <dbReference type="KEGG" id="ovi:T265_14884"/>
    <dbReference type="CTD" id="20329050"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="409"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="575"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="81436" checksum="DFFB757625378196" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7D4</accession>
    <name>A0A075A7D4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172887.1">
        <property type="nucleotide sequence ID" value="XM_009174623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7D4"/>
    <dbReference type="STRING" id="6198.A0A075A7D4"/>
    <dbReference type="GeneID" id="20322917"/>
    <dbReference type="KEGG" id="ovi:T265_08738"/>
    <dbReference type="CTD" id="20322917"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="195" mass="22767" checksum="3E4F901D4D0E51F5" modified="2014-10-01" version="1">MYRDSYQGGLLSIFYSLGSNPLKDWSQKVSNGHIKRVTDEDIQSFVYEIVGTNVSTAFLKCPANSAQTLSIRLPILVIVLKNLKKYFTFEVQILDDQNVRRRFRASTFQTMTLVKPFACTMPMNLDEGWNQVQFDLCEFTRRAYGTGFVEVLQVEIHANCRLRRVYFCDRMYSEEELPREYKLYLPIRASSTPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7I6</accession>
    <name>A0A075A7I6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596643">
        <property type="protein sequence ID" value="KER31620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164572.1">
        <property type="nucleotide sequence ID" value="XM_009166308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7I6"/>
    <dbReference type="STRING" id="6198.A0A075A7I6"/>
    <dbReference type="GeneID" id="20316322"/>
    <dbReference type="KEGG" id="ovi:T265_02134"/>
    <dbReference type="CTD" id="20316322"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER31620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="507" mass="58147" checksum="7B56C5A68E53C4D4" modified="2014-10-01" version="1">MRFGIINVVLSVLALCAFWIYHGTNHWDEKTVTHHTYGFVYHAQETDGEFRLHSNDLTKWIAEMNDERLKNSSVRLSLLTIFAALCNLTKYDSPNPALELCCGHTQRYLNKLDLIWCLQNMGHIGTVPTVREVWNSTRSLPVYPPTYNNSMVYRKDVQLSDGVTGCQVDLLRRENMYQLFLKWIQMAEKHKIVWWLTYGSLLGSVRCSQNVHLGKQPSDHKGNYSQVAENSSTTHDRFRPSWGSPGRRSFQTVFEKYTHLCLPYESQEGRNLSWAVEEFSATLHKDFIPYDHDTDVAVLGSYETIVRELSVTWKDATYEQVFSVDTSGEAQSPSFRQPYVLLETKLREISEMHSFANKFGFARDSPGTRPFLISRHCRIGHGMSLNCRGLPGHFHEDPCVFCAPIARIISGPHMYFDVFLVHAKVVVDESNANETHVGLLDESVDSERKKRLSYSLNDVFPLSICTYMGLNVPCPRNPDSVLAHVYGKDYMKPQKLCDQRSGIWHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8B1</accession>
    <name>A0A075A8B1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596840">
        <property type="protein sequence ID" value="KER23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172569.1">
        <property type="nucleotide sequence ID" value="XM_009174305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A8B1"/>
    <dbReference type="GeneID" id="20322670"/>
    <dbReference type="KEGG" id="ovi:T265_08491"/>
    <dbReference type="CTD" id="20322670"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="69" mass="8097" checksum="F0C631F5FF03831E" modified="2014-10-01" version="1">MCFTRPPHISLATIFEISRYMYIHSALLIRLLRIRRQRTTGFVLLGAHQTHLLTFLAATTLIERPEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A8G3</accession>
    <name>A0A075A8G3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596638">
        <property type="protein sequence ID" value="KER32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164238.1">
        <property type="nucleotide sequence ID" value="XM_009165974.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A8G3"/>
    <dbReference type="GeneID" id="20327040"/>
    <dbReference type="KEGG" id="ovi:T265_12872"/>
    <dbReference type="CTD" id="20327040"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22396">
        <property type="entry name" value="KH-I_FUBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22399">
        <property type="entry name" value="KH-I_FUBP_rpt4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000131">
        <property type="entry name" value="Protein CBG26278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="578"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1783"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1786"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1816" mass="201758" checksum="D7B54FCFE92A2EAF" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A900</accession>
    <name>A0A075A900_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_01782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164136.1">
        <property type="nucleotide sequence ID" value="XM_009165872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A900"/>
    <dbReference type="STRING" id="6198.A0A075A900"/>
    <dbReference type="GeneID" id="20315970"/>
    <dbReference type="KEGG" id="ovi:T265_01782"/>
    <dbReference type="CTD" id="20315970"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="149" mass="17985" checksum="FF97DDCFC0D43864" modified="2014-10-01" version="1">MSSFLEKLSTLRMIIRQNGGLLNSMRVLFRTDELKWGTYVGMDQFGNKYYQNDKYFFGKFSFISYFWAILGRDRWVIYGNRFGWDYEGSQVPPEWHRWLHHMTDESPVDKPPRRLKWMAEHSENTTLDPNKKYIPYSTTKPKIEPWKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABQ1</accession>
    <name>A0A075ABQ1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_00770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596626">
        <property type="protein sequence ID" value="KER33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162906.1">
        <property type="nucleotide sequence ID" value="XM_009164642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABQ1"/>
    <dbReference type="STRING" id="6198.A0A075ABQ1"/>
    <dbReference type="GeneID" id="20314958"/>
    <dbReference type="KEGG" id="ovi:T265_00770"/>
    <dbReference type="CTD" id="20314958"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000067">
        <property type="entry name" value="NK6 homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF35">
        <property type="entry name" value="HGTX, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="465"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="467"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="722"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="816" mass="88941" checksum="8D68F9FEBC9CFFB5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ABS2</accession>
    <name>A0A075ABS2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596787">
        <property type="protein sequence ID" value="KER25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171160.1">
        <property type="nucleotide sequence ID" value="XM_009172896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ABS2"/>
    <dbReference type="GeneID" id="20321571"/>
    <dbReference type="KEGG" id="ovi:T265_07392"/>
    <dbReference type="CTD" id="20321571"/>
    <dbReference type="OrthoDB" id="6314955at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="125" mass="13901" checksum="69D4C67481E5B6E0" modified="2014-10-01" version="1">MSAYECESTTVSSYLLDEHCLTRSIADVRGLALVRGCDALHIAGALYTEDRFPTGGDSDEEDEAKGRTGENPVLLLCHSCMDRTRTACQTMWTTQEELRYTSPGLYAIKHGFFTTFRVLSSNMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACP5</accession>
    <name>A0A075ACP5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_00397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162434.1">
        <property type="nucleotide sequence ID" value="XM_009164170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACP5"/>
    <dbReference type="STRING" id="6198.A0A075ACP5"/>
    <dbReference type="GeneID" id="20314585"/>
    <dbReference type="KEGG" id="ovi:T265_00397"/>
    <dbReference type="CTD" id="20314585"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF164">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="324" mass="35961" checksum="9370BDC8E63F3E05" modified="2014-10-01" version="1">MSKQPNQVLNVSQTPTGQTMSWRLITQAYYRLPVMVGHGDMQMNRLCRDHAGELAAIIFWLMSPCVRSPCITTPDPASLTSVVHPYMTQPFPVDYMTALFSASRIIPPRLASPATTPRAPMASGASPNVTAFNPMLYFAAATQLLLHSLIPSTQTYPRLAAPVSSNLTLPDSPSPSELSDFNRLNASRGAPTSSNNMGRARRKPPPETTSPVESSNNRNMEPVSSTGQSGIREKKYQCTYPGCSKAYYKRSHLNEHSHLHTGLKPHLCGQPGCGARFTRADQLSRHRRAHTGERNFFCKVCQRRFKRSDHLKVHLSRNVCTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ACQ7</accession>
    <name>A0A075ACQ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosyl-methyltransferase MraW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_12532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162520.1">
        <property type="nucleotide sequence ID" value="XM_009164256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ACQ7"/>
    <dbReference type="STRING" id="6198.A0A075ACQ7"/>
    <dbReference type="GeneID" id="20326700"/>
    <dbReference type="KEGG" id="ovi:T265_12532"/>
    <dbReference type="CTD" id="20326700"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52879" checksum="2EC4565DD111CFB8" modified="2014-10-01" version="1">MFNRILSEVHSAVVFFPRTLMFSGKRFNHIPVMEREIVDFLSPKPNEVLLDMTFGAGGHTRALLETTPSLKCYCLDRDQEFLSHFEQLKNTLGSTTQTFVALLGKFSDLPRLCQQHGLGAGTVDMIVMDLGVSSMQLDNPERGFAFKTECSLDMRMDGPAQSNQHEFTDNQSVVTPFRCLAAMPREGSTRAGMLPGCPSLDRGSREAEVGPEPQTFRSVNSRSTHPSHLAPVRIYRPSTVHIFHLKEIGLLSLTNTTVSNGSTPTAADVLNNLSAADLAQIFRLYGEERYSRRIANAITDHRHTLGPIRTTKQLADIVCSVVPSRSTNAQPGSSTHPATRVFQALRIFVNDELNELCVGLELAEKLLKPATPCPGGRAGRLAVISFHSLEDRIVKWAFSVPTTKTDVGLAVALANRTTASMTGIHRRQALLRQLDPAASESLSVRSPRWAYTTELSMPTEEEISRNQRARSAKLRGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD14</accession>
    <name>A0A075AD14_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170455.1">
        <property type="nucleotide sequence ID" value="XM_009172191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD14"/>
    <dbReference type="GeneID" id="20320996"/>
    <dbReference type="KEGG" id="ovi:T265_06817"/>
    <dbReference type="CTD" id="20320996"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="215" mass="24758" checksum="EDEFD510C6A85F0E" modified="2014-10-01" version="1">MQAPTEQHRERYAPNLPNDDSEPTQVDVSYMDDLSQRLLSRTFRYKRRKSTFTLFLPDFQTEYHRHFENALLRYLCNYDDLIIKSSLTVTDFELNIIDDHNRPSNHLLTQNNATCPSSQRLRSTESQCFAWPGDPDTIAHGIHGTPSTANSKKTRTSDTNFNNPTTHDQQAMPGASEPKSVERNGILYVVGFKFPWSINRPLIFHSLTLKMPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD15</accession>
    <name>A0A075AD15_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596620">
        <property type="protein sequence ID" value="KER33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162146.1">
        <property type="nucleotide sequence ID" value="XM_009163882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD15"/>
    <dbReference type="GeneID" id="20314362"/>
    <dbReference type="KEGG" id="ovi:T265_00174"/>
    <dbReference type="CTD" id="20314362"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="475" mass="52082" checksum="EABDB06562E684CC" modified="2014-10-01" version="1">MMLERQFDPSLARVYDGRRRRFYADSVGYDTPFVRHGTRFATKESEGIKYLLRCTPSAMLTDGGGIATNASSPFSWLIEVGRPKIGFSAASDIPVNCSYSRQSDEQMHYSEALQKQLDYRHNNNKYVVGCTHTKDGKSKRVPVCAAVEELHMTVYGSGPEKSIYSSGRQLVIYEDGTLDPNYRNAKYQALRNHRLDENSRRCKKVRFILNRLNHGCSRLDASSPGQQNFGPPAAYPGADSYFLHYPELNMPGAFGNSVLAIESRRALTPKDVHSSAVGPAGYLPPYSATSGGHIPSNCGMPLSSPGSGSVAHPYMFSPDMSGSCCKMAPGLRPSQAGSCTHDLTSASLASLARLSQLSGSEPVRPVFGCGRTNGRTSVVRLYSLVLWDKWQPEQGQSSYRQTETLLFFGFPELKARLRTTGDGRYTRATGEFIEECTVGNLVEGLANIKIDKDNTQSGIVGGRNMIEEVNLACVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AD88</accession>
    <name>A0A075AD88_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596762">
        <property type="protein sequence ID" value="KER25914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170321.1">
        <property type="nucleotide sequence ID" value="XM_009172057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AD88"/>
    <dbReference type="GeneID" id="20320899"/>
    <dbReference type="KEGG" id="ovi:T265_06720"/>
    <dbReference type="CTD" id="20320899"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="260" mass="29217" checksum="1714952608D2BFF0" modified="2014-10-01" version="1">MYLSNLTGHSKSWRLCPIERWPTTQQKPAYGSHQEGVVTYLLDVPRNQNHLADWLSRPEAEDEAPRIRFAVNSLVVELDRCVQQFGTKACNSLGDCIEADPGVDLWINEVKTQLPRSSVTLLGHKMGHGLFSQLPEKLAKIEDCAVANSKRTLRQFFWTSSILQQITEISERGLSPSDSQIGLINNTAVKANTTFNDATNLEYLATLEAAMKYIQHLRETVVPAVTRNTAFIAVSNEEKEAMNKLKIEETSPFCRLTRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADZ5</accession>
    <name>A0A075ADZ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169879.1">
        <property type="nucleotide sequence ID" value="XM_009171615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADZ5"/>
    <dbReference type="GeneID" id="20320556"/>
    <dbReference type="KEGG" id="ovi:T265_06374"/>
    <dbReference type="CTD" id="20320556"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="107" mass="12515" checksum="4BB878058324356A" modified="2014-10-01" version="1">MILELTWPLIEYRLSAVSYCRALYPNADAREWITPWPVVQNWNYDMGTFKLSLVFDFELLHTCEFIHKDTKVIVLVFRLPLDNKHGGWLQVGSKKTLSKETTPDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEI6</accession>
    <name>A0A075AEI6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596739">
        <property type="protein sequence ID" value="KER26754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169471.1">
        <property type="nucleotide sequence ID" value="XM_009171207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEI6"/>
    <dbReference type="GeneID" id="20320219"/>
    <dbReference type="KEGG" id="ovi:T265_06037"/>
    <dbReference type="CTD" id="20320219"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="8963" checksum="BCB4DB8FE98DC2E6" modified="2014-10-01" version="1">MPSAESTRTQIRLGCPSLDRNSRVQTKDLPVAQCKPQRIQSINQFISYKPCAIGTFDPAATGSITGKQKSETHNQALKANEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFD2</accession>
    <name>A0A075AFD2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168679.1">
        <property type="nucleotide sequence ID" value="XM_009170415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFD2"/>
    <dbReference type="GeneID" id="20319599"/>
    <dbReference type="KEGG" id="ovi:T265_05417"/>
    <dbReference type="CTD" id="20319599"/>
    <dbReference type="OrthoDB" id="6266369at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="19236" checksum="B01C09DAB2FF9D89" modified="2014-10-01" version="1">MYGTWGEIAQLSGRKSTDLEERGSNLISDPRLTLSRLGQPGSSPVLVLPSGDVAARLERRQQTQALHVTRGDVHHYHKHQTFAPEAKSIHDCVFHRIARVIFHIFCKTYFKPLLRYTNQTVYSERRKNVTFVVHAQRASRKMVRCLKSVCYKKRLTVLDLLEYCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFL9</accession>
    <name>A0A075AFL9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596712">
        <property type="protein sequence ID" value="KER27899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168374.1">
        <property type="nucleotide sequence ID" value="XM_009170110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFL9"/>
    <dbReference type="STRING" id="6198.A0A075AFL9"/>
    <dbReference type="GeneID" id="20319360"/>
    <dbReference type="KEGG" id="ovi:T265_05178"/>
    <dbReference type="CTD" id="20319360"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="262" mass="28827" checksum="DF52EF2D3DCB522C" modified="2014-10-01" version="1">MDKVLGVKKLLEERLVNVYSCSPSVSQKETPMTGFDIHRALKQGNPSLLREILGKEEAYLEAPDNLGFTPLMYCAQRNLQDMMEVLLDWSADPNTQDSTGKTALMFAAFKGNIECMETLLDCGSDVNITDQNGLTALHMAVDGEQPRAIRLLVKSGAKLEAKEVGMKWTPLLRCAGLKNNGNVEVAHELVRLGAEIDAADEDGKTALHNAILNGHHDLCDFLIKHGASLELTTRTNHNAVELAESFGNRVSLNLFEIIRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AG23</accession>
    <name>A0A075AG23_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596702">
        <property type="protein sequence ID" value="KER28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167947.1">
        <property type="nucleotide sequence ID" value="XM_009169683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AG23"/>
    <dbReference type="GeneID" id="20319019"/>
    <dbReference type="KEGG" id="ovi:T265_04837"/>
    <dbReference type="CTD" id="20319019"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="7902" checksum="20FCC36D69CA040C" modified="2014-10-01" version="1">MKPSVFVRYGGLLDRSSAPVRIGSVHHFPAVPTAPVQRPMFGFGDSKRTKQARGNKMVGKHLQTADKRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHD6</accession>
    <name>A0A075AHD6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596673">
        <property type="protein sequence ID" value="KER29699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166527.1">
        <property type="nucleotide sequence ID" value="XM_009168263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHD6"/>
    <dbReference type="GeneID" id="20317903"/>
    <dbReference type="KEGG" id="ovi:T265_03716"/>
    <dbReference type="CTD" id="20317903"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="252" mass="28430" checksum="DD3491CE8EC0D1CD" modified="2014-10-01" version="1">MYEAEIQNAAPDKPPFEIIGFWGFARNSTWYNRLLESIHSTQIRKSNLKYSNPELANGINDISDNTVDHDICISQPPLFSQHSPPKPSVAGSVRSSRYVGRQKSRSENEILEKELAIEMKKLEIRRRKLASCKQMLLSYDSSDDENSICGDCELGFPSSKPKAEKFVAKFNSEEMERTNLSTNQPRKGDAAGIRTAADILISFRLVCLKKLVCMSSSPQRMLRRLVSCLSGLITFKLGKTELRTGFNLLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHU4</accession>
    <name>A0A075AHU4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596660">
        <property type="protein sequence ID" value="KER30489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165767.1">
        <property type="nucleotide sequence ID" value="XM_009167503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHU4"/>
    <dbReference type="GeneID" id="20317285"/>
    <dbReference type="KEGG" id="ovi:T265_03098"/>
    <dbReference type="CTD" id="20317285"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="412" mass="44888" checksum="3B8999215C9AD9E5" modified="2014-10-01" version="1">MRPELAGPVTVQAVHPQGQQVSSTSQLKVATPVTLAPMTAETVQPIEEFQAVPEDQMRFTETEAPEMQPKPEEYKIAPQFVQTLPSTVTPAIGATVALEVIVTGQPQPDVQWTVSSPQTSSRCEIVPAEEVDQVTTHHQLLIHDVKTDDYRTTVQVVATSEIGQATSVCQLEAPAERLEFTKTLSPELEVAEATPVLLECAVQPTPTPVDFHWYVQGVEVTPETQGVVIQSTSHTSQLHIEQMRPELAGPVTVQAVHPQGQQVSSTSQLKVATPVTLAPMTAETVQPIEEFQAVPEDQMRFTETEAPEMQPKPEEYKIAPQFVQTLPSTVTPAIGATVALEVIVTGQPQPDVQWTVSSPQTSSRCEIVPAEEVDQVTTHHQWWIHDVKTDDYRTTVQVVATSEIGQATSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIT2</accession>
    <name>A0A075AIT2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164143.1">
        <property type="nucleotide sequence ID" value="XM_009165879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIT2"/>
    <dbReference type="GeneID" id="20315977"/>
    <dbReference type="KEGG" id="ovi:T265_01789"/>
    <dbReference type="CTD" id="20315977"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF37">
        <property type="entry name" value="HOMEOBOX PROTEIN SLOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="591" mass="65759" checksum="27A5CA1C8B9F1C30" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJ16</accession>
    <name>A0A075AJ16_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prospero domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596632">
        <property type="protein sequence ID" value="KER32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163647.1">
        <property type="nucleotide sequence ID" value="XM_009165383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJ16"/>
    <dbReference type="GeneID" id="20326932"/>
    <dbReference type="KEGG" id="ovi:T265_12764"/>
    <dbReference type="CTD" id="20326932"/>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="8">
        <location>
            <begin position="510"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120588" checksum="2427D262AB153110" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AJE2</accession>
    <name>A0A075AJE2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163073.1">
        <property type="nucleotide sequence ID" value="XM_009164809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AJE2"/>
    <dbReference type="GeneID" id="20315102"/>
    <dbReference type="KEGG" id="ovi:T265_00914"/>
    <dbReference type="CTD" id="20315102"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="193" mass="22177" checksum="8ACB7C3B6011F0DB" modified="2014-10-01" version="1">MLLSSTLSLFSRSTIPTVGCITRDNSTAVILCPEAPQMNLNVSIKGNKCDVRMDSITLAPDEEGNRTKDVPLGARMSRWSRRPGWNRPVMLTMTKFFTPVVKNSERSSRRVKEVEAQKSSSLEQISYVGWMQAFTQRLRSRAERIKLFNLLWKVQFANTSEMLIILMLTTENGHYWGENRQVVSQRIYDVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTZ6</accession>
    <name>A0A074YTZ6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL607543">
        <property type="protein sequence ID" value="KER18178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178075.1">
        <property type="nucleotide sequence ID" value="XM_009179811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTZ6"/>
    <dbReference type="STRING" id="6198.A0A074YTZ6"/>
    <dbReference type="GeneID" id="20330406"/>
    <dbReference type="KEGG" id="ovi:T265_16241"/>
    <dbReference type="CTD" id="20330406"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="15579" checksum="70CA3B56162A95C2" modified="2014-10-01" version="1" fragment="single">SSGCSLSCSGTSGNLSGSAVASGVPSCASILSDQITGESRPQSATDLSASHPVVLMVHGKKVTVPPPIPGHAKFTSYLLDGEGTLRQASGGAAPSGSTTHLLPDSLPLDQGFSSMRLSKSDGHLAMTNAEPSSDVELVSHSHEDESKLNSPQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YUL0</accession>
    <name>A0A074YUL0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL601921">
        <property type="protein sequence ID" value="KER18393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177860.1">
        <property type="nucleotide sequence ID" value="XM_009179596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YUL0"/>
    <dbReference type="STRING" id="6198.A0A074YUL0"/>
    <dbReference type="GeneID" id="20330254"/>
    <dbReference type="KEGG" id="ovi:T265_16089"/>
    <dbReference type="CTD" id="20330254"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="13793" checksum="D55EB321D9920C8B" modified="2014-10-01" version="1" fragment="single">MLFDLIETAIHAKENFKGTIQPLFPREKPEPIGNGQSHVPPTTTSVNSGRDSVFLDSTEGNTTHNSSSNNSVTPLGGSSLAGRVARSPVFAVSSQINVSLAYANAYGEWLNPEKEALLYTADAPFPFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVS0</accession>
    <name>A0A074YVS0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597629">
        <property type="protein sequence ID" value="KER18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177387.1">
        <property type="nucleotide sequence ID" value="XM_009179123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVS0"/>
    <dbReference type="GeneID" id="20326291"/>
    <dbReference type="KEGG" id="ovi:T265_12123"/>
    <dbReference type="CTD" id="20326291"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="99" mass="11496" checksum="4B71D41D43C67860" modified="2014-10-01" version="1">MKQQKPQLICPEMSIARTSLLRYLFYPYKFKVIQTSSQYAHVLFGLESHLRPGPLESRGSRPAYRDIIRHCLAIHMLPTHHSIPPLSAIHFPDKYAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWR2</accession>
    <name>A0A074YWR2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597290">
        <property type="protein sequence ID" value="KER19211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177047.1">
        <property type="nucleotide sequence ID" value="XM_009178783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWR2"/>
    <dbReference type="GeneID" id="20326109"/>
    <dbReference type="KEGG" id="ovi:T265_11941"/>
    <dbReference type="CTD" id="20326109"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16153" checksum="1A89049D05C3AD7A" modified="2014-10-01" version="1">MTSTFGNVRDRAVLRNMHRTLVGHRLQEMCRLPTVTTPSVSNSRPEQVASEPDTATKHPRKHSLWEYKPSIQKGQIPRIPSKKDASELKTTLPSVNSGWAHVRHANNHLNPTSVALRTKSLRNRYSHQAGYDTVTPVVSGLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXJ4</accession>
    <name>A0A074YXJ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_11730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597189">
        <property type="protein sequence ID" value="KER19521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176732.1">
        <property type="nucleotide sequence ID" value="XM_009178468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXJ4"/>
    <dbReference type="STRING" id="6198.A0A074YXJ4"/>
    <dbReference type="GeneID" id="20325898"/>
    <dbReference type="KEGG" id="ovi:T265_11730"/>
    <dbReference type="CTD" id="20325898"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER19521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="453" mass="50321" checksum="176FABBDF9DB29FE" modified="2014-10-01" version="1">MTQLPPPTTPKILAQNDTKNVTDGLEPFSGQEYAHILVLLSSVYTQVLAGLCALVACCVTLHHIYCHLKNYTRYEEQRYIIRILILIPAYAFYSFTSVMLAVHARQNSVYIEPIHDIAEAIAIYSFLALCYQYLGGEGSIMLELTGKTIRKIDPAFFMVLVVLRESHIRSSSSGSVKCPNSGYLYLFLINNFTVTLALYGLLLFYFATRDQLRPFKPLLKFATMKAIIFFSFWQDVLFSILEWSHVVSGSQGYPAGLLAAGCKNVLVCIELVITAIALRYAFPYSIYVLHHPPRLVLDLPLGGQDWSGFAGTNPLGQDVVFKESAANVNNKLRTLRADLLIGTSAFAERSPPTNQAQPEPLPWDIAESRLQIDDPEPHTWDGHNSVTLPTISASIKATIDPRDIFVDAVHNFHPNYRHYTQQGIISDEGLLAGTSKSLTIACGYGCGSIFSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY61</accession>
    <name>A0A074YY61_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597169">
        <property type="protein sequence ID" value="KER19608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176643.1">
        <property type="nucleotide sequence ID" value="XM_009178379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY61"/>
    <dbReference type="STRING" id="6198.A0A074YY61"/>
    <dbReference type="GeneID" id="20325833"/>
    <dbReference type="KEGG" id="ovi:T265_11665"/>
    <dbReference type="CTD" id="20325833"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER19608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="129" mass="14877" checksum="9A973592023B69E8" modified="2014-10-01" version="1">MVRTCNLNARRPSASQSFFPSPVLSGGGREVYDMATKYENTNQQTFSGWKLPPPWMMIEITCNDRLGKKVRVKCNPTDKVGDLKKLIAAQTGTPPDRIILKKWYTIFKDHITLRDYEINDGMNLELYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYE5</accession>
    <name>A0A074YYE5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL606250">
        <property type="protein sequence ID" value="KER18207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178046.1">
        <property type="nucleotide sequence ID" value="XM_009179782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYE5"/>
    <dbReference type="STRING" id="6198.A0A074YYE5"/>
    <dbReference type="GeneID" id="20326508"/>
    <dbReference type="KEGG" id="ovi:T265_12340"/>
    <dbReference type="CTD" id="20326508"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11334" checksum="82D3E7D95085032E" modified="2014-10-01" version="1">MVEGKWELIGQMNRRKSNLSSTVVNDDIYILGGWSDEPEAGILDLVERFDTTTRECHIVRPLTFPASATCACTLKDRNLVKKYIRPLPIGYVQNTGEFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YYQ8</accession>
    <name>A0A074YYQ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597117">
        <property type="protein sequence ID" value="KER19931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176334.1">
        <property type="nucleotide sequence ID" value="XM_009178070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YYQ8"/>
    <dbReference type="GeneID" id="20325587"/>
    <dbReference type="KEGG" id="ovi:T265_11419"/>
    <dbReference type="CTD" id="20325587"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER19931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="166" mass="19186" checksum="BACBFE7026C88E6D" modified="2014-10-01" version="1">MRLVSRNRPFSRVFLKFDGYLLTTTQLQTNTAEQFHKFHNKPHLPIDARRNSQKATSVASSVTSAVAPSFLTDSGSVPPFTWLYVKNSLRKSVDWLTQHVAKQLQPMRCDQFIYRDCSTLSAPNCHATQRKHEGWDTARLLKSRQENSRGRYRVRTTDLLVCKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZR2</accession>
    <name>A0A074YZR2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL598653">
        <property type="protein sequence ID" value="KER18692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177561.1">
        <property type="nucleotide sequence ID" value="XM_009179297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YZR2"/>
    <dbReference type="GeneID" id="20326357"/>
    <dbReference type="KEGG" id="ovi:T265_12189"/>
    <dbReference type="CTD" id="20326357"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="93" mass="10747" checksum="F26D9489667143AA" modified="2014-10-01" version="1">MSSLYELTYAIWFRFCARCFTVDCTDSPAFGSCLLPFGGAQQPTAFLLARFGFARWYVRFTNLCTYGILRLWSENMVLISQATERKHNREPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YZX5</accession>
    <name>A0A074YZX5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_15370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597078">
        <property type="protein sequence ID" value="KER20208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176035.1">
        <property type="nucleotide sequence ID" value="XM_009177771.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074YZX5"/>
    <dbReference type="GeneID" id="20329535"/>
    <dbReference type="KEGG" id="ovi:T265_15370"/>
    <dbReference type="CTD" id="20329535"/>
    <dbReference type="OrthoDB" id="6246449at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1589" mass="176869" checksum="1DC5484FB6887D90" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z0A1</accession>
    <name>A0A074Z0A1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597065">
        <property type="protein sequence ID" value="KER20353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175909.1">
        <property type="nucleotide sequence ID" value="XM_009177645.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z0A1"/>
    <dbReference type="GeneID" id="20325252"/>
    <dbReference type="KEGG" id="ovi:T265_11084"/>
    <dbReference type="CTD" id="20325252"/>
    <dbReference type="OrthoDB" id="6247010at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
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                <person name="Maleewong W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A074Z3C7_OPIVI</name>
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        <recommendedName>
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        <lineage>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
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                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneID" id="20329239"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="29652" checksum="3EC99712DA160C8F" modified="2014-10-01" version="1" fragment="single">ISGRVRVYGELSKSFRTQSGVRQGCPLSPFLFNFVIDEIMRRTLEGLQNPGVQIASEENLVDLEYADDIVLMFEEEEKAQVFLDELTKVIPSFEKSLVSETDELAKTDPKKLRLVVIDGSNVAYEYGNKQFNPEGIRLAVEFFTQRGHTNVVAVVPRFRQAKGGLLFDKLEREGHLYYSPSRLVNGIQRASDDDKVILEVAARENGVVVSNDQFRNYLHIDRLRSVIENRLPFVMIRNAFFVTDDPHGRDGPSLSQCLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z3L9</accession>
    <name>A0A074Z3L9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596953">
        <property type="protein sequence ID" value="KER21628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174631.1">
        <property type="nucleotide sequence ID" value="XM_009176367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z3L9"/>
    <dbReference type="GeneID" id="20329216"/>
    <dbReference type="KEGG" id="ovi:T265_15050"/>
    <dbReference type="CTD" id="20329216"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="120" mass="13592" checksum="72D0090E9C9E277B" modified="2014-10-01" version="1" fragment="single">SQWEEYYYDHYGTYLAVEVAVPIVVFFVVVTVIVLTVVCIRRQRILRGRAMIQREAVPPQPVVVPKPGTSYPPSEVNPPPYWEGAQDGQPPYPIEEPPPYPDMLRGPVPNKPPMPPMLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z414</accession>
    <name>A0A074Z414_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_16326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL614130">
        <property type="protein sequence ID" value="KER18055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178198.1">
        <property type="nucleotide sequence ID" value="XM_009179934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z414"/>
    <dbReference type="GeneID" id="20330491"/>
    <dbReference type="KEGG" id="ovi:T265_16326"/>
    <dbReference type="CTD" id="20330491"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="42" mass="4468" checksum="0C00BA70D4E06768" modified="2014-10-01" version="1" fragment="single">EHSLTTTGSVLCVQPHCALSPNLRYVIDGVHASTGCGRENFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z444</accession>
    <name>A0A074Z444_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596938">
        <property type="protein sequence ID" value="KER21823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174431.1">
        <property type="nucleotide sequence ID" value="XM_009176167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z444"/>
    <dbReference type="STRING" id="6198.A0A074Z444"/>
    <dbReference type="GeneID" id="20324108"/>
    <dbReference type="KEGG" id="ovi:T265_09940"/>
    <dbReference type="CTD" id="20324108"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER21823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="144" mass="16860" checksum="7294C3CB277230E9" modified="2014-10-01" version="1">MHEEEERRLLEKFQRMDKDNSGSLSRKEVKQCMKSCGFDTKFINEFIKTFDLDGDGQITLSEYQRVLNILPAHEKEMAMWRSVFNDVDADKSGKISFAELQKLMIEMGYECQALDLKAWMSTQDLDKDGELNLDEFIRFIKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z454</accession>
    <name>A0A074Z454_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="11">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_09929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:22650"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="11"/>
    <dbReference type="EMBL" id="KL596937">
        <property type="protein sequence ID" value="KER21833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009176150.1"/>
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    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
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    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER21833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="222" mass="25330" checksum="058B0ABF766D09E9" modified="2014-10-01" version="1">MGSLTSQLSAPSQVTTDGQSECPVHTPIGGCPFRDRTALDPSNMMPPPNQQPSPGQPFPLSTDREVSTIPKADDPNGGTWIYPSAQMFWNAMLRKGWRWRDEDVTQQDMEHIIRIHNVNNELAWHEVLKWEALHAKYELPFDRHDWIVDRCGRDVRYVIDYYDGGPVDEHGRFTLLDVRPALDSVEAVYDRARVAWMRFRSPEPPVPRDPSLDSPSNQTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z475</accession>
    <name>A0A074Z475_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597068">
        <property type="protein sequence ID" value="KER20317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175928.1">
        <property type="nucleotide sequence ID" value="XM_009177664.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z475"/>
    <dbReference type="GeneID" id="20325269"/>
    <dbReference type="KEGG" id="ovi:T265_11101"/>
    <dbReference type="CTD" id="20325269"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="417"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1618" mass="176555" checksum="EEFA18201B1D827E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z496</accession>
    <name>A0A074Z496_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596935">
        <property type="protein sequence ID" value="KER21878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174388.1">
        <property type="nucleotide sequence ID" value="XM_009176124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z496"/>
    <dbReference type="STRING" id="6198.A0A074Z496"/>
    <dbReference type="GeneID" id="20324076"/>
    <dbReference type="KEGG" id="ovi:T265_09908"/>
    <dbReference type="CTD" id="20324076"/>
    <dbReference type="OrthoDB" id="300500at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER21878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22118" checksum="5AEEF0F3664D923E" modified="2014-10-01" version="1">MEYVGDSYVGEYKNERLDSLSCTSEQPSYRMEGQGTYTLSTGTRYVGGMKDGMFHGEGTLYYTGGSKFVANWVNGHPENGKIIFSDGLEYVEGSHYCDEYDRRFYTEICNGLKPAGRSQLVNNEPPRQIPEGCYDTGDGFYDPIKRIVVSYEGKFLRNADTDEHSWIIAKCRKAWDEHVGATYDHTVEGEISKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4S9</accession>
    <name>A0A074Z4S9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_09755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KL596922">
        <property type="protein sequence ID" value="KER22068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174190.1">
        <property type="nucleotide sequence ID" value="XM_009175926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4S9"/>
    <dbReference type="STRING" id="6198.A0A074Z4S9"/>
    <dbReference type="GeneID" id="20323923"/>
    <dbReference type="KEGG" id="ovi:T265_09755"/>
    <dbReference type="CTD" id="20323923"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="83"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER22068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="390" mass="44923" checksum="22B60A035C85D849" modified="2014-10-01" version="1">MAGDTEATFVLSLDDDLDDATQAKENTFEISISLVDDAPEQKASTMDLEQQLSWFHEFLQREREVFLRKYENPSQNTAALDQFERLKTLGTGSFGRVMLVRHKVDQNYYAMKILEKQKVVKLKQVEHTMNEKTILQAINFPFVVGMAYSFKDNTNLYMVLDFVSGGEMFSYLRRVGKFSEEDARFYASQVVLAFEYLHSFDLVYRDLKPENLLIDSAGYLKVTDLGFAKRISGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGILIYEMTCGYPPFFADQPIQIYEKIVAGKVRFPGHVSSDLKNLLKQLLQTDLTKRFGNLKNGVNDIKCHRWFTPINWVVIYRKEATAPFIPPCKGPGDTSNFDDYEEEPLRITNTNYCAKEFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z5R8</accession>
    <name>A0A074Z5R8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596897">
        <property type="protein sequence ID" value="KER22481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173784.1">
        <property type="nucleotide sequence ID" value="XM_009175520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z5R8"/>
    <dbReference type="GeneID" id="20323622"/>
    <dbReference type="KEGG" id="ovi:T265_09453"/>
    <dbReference type="CTD" id="20323622"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="200" mass="22943" checksum="29A68182B8DD071F" modified="2014-10-01" version="1">MSRKFGFYFQDGGATFVMGDNLEQLITDPVTYINVAQGPYWETRVNWIFIDDSGFCTEDHRMLFDTGTNTIDLPGDIHMTINNVLGIWRTMHHVYVFDCERLPDLPPITFQIQGKMLQIMPKQYTKQVDNRFHTCDQPIEHSTTTTNYDVSCCTRFQNTTPNCFVGIILGMSFLHSFQLIFDDHAGTVGFSARPGRSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z641</accession>
    <name>A0A074Z641_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_15182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL597001">
        <property type="protein sequence ID" value="KER21022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175227.1">
        <property type="nucleotide sequence ID" value="XM_009176963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z641"/>
    <dbReference type="STRING" id="6198.A0A074Z641"/>
    <dbReference type="GeneID" id="20329347"/>
    <dbReference type="KEGG" id="ovi:T265_15182"/>
    <dbReference type="CTD" id="20329347"/>
    <dbReference type="OrthoDB" id="8953942at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF4">
        <property type="entry name" value="LD18634P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER21022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="331" mass="37011" checksum="7D583B02D25EDC1A" modified="2014-10-01" version="1" fragment="single">MKYNSSNSNRNSQDSLSRDDVLNESQRHFTTRLHCTKYSLERYSSGSLKRKAVGSKQDTTVFPNRIVPTARIKARLAQIPNLLGPYICKLCHREFRDPFHLAGHRCPCIIHTDYRCPECEKRYTGCLKRSPVFNCPANLASHRRWHKPKRINNCLEGINSLGSNVAMATTAKADNYPIQTISDYPKTTPSKTLSRNSEPTHPSDRARNCAVPWSQDPLGANFDDTGSIKIAARTRQLSKNCNSFTVDAILGRTTVSQTRSRGGVVEESHQPRNSITQSFKPAHPHQLWKTAEIDCSQDAVFPHNGPRHVELVPVSDAGPTMDGNVKVGSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z6K1</accession>
    <name>A0A074Z6K1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_09180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596879">
        <property type="protein sequence ID" value="KER22811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173455.1">
        <property type="nucleotide sequence ID" value="XM_009175191.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074Z6K1"/>
    <dbReference type="GeneID" id="20323359"/>
    <dbReference type="KEGG" id="ovi:T265_09180"/>
    <dbReference type="CTD" id="20323359"/>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER22811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1375" mass="151550" checksum="E29547382C4094DC" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z893</accession>
    <name>A0A074Z893_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596941">
        <property type="protein sequence ID" value="KER21777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174463.1">
        <property type="nucleotide sequence ID" value="XM_009176199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z893"/>
    <dbReference type="GeneID" id="20324131"/>
    <dbReference type="KEGG" id="ovi:T265_09963"/>
    <dbReference type="CTD" id="20324131"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="16012" checksum="83FDA19723085599" modified="2014-10-01" version="1">MKVHEANEMFAPGGTQDELTCPKLRDHSEPEIRQWNAQKHATILYLLRKNINVLFHYMKPHRRNKPSAFSLRAGNGEPTSEWYWDREISNFVYRLSRFECFLSRKFCERQPLTDKNKTDPGDLGKSLDPVYQSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAF4</accession>
    <name>A0A074ZAF4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_11208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597082">
        <property type="protein sequence ID" value="KER20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176070.1">
        <property type="nucleotide sequence ID" value="XM_009177806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAF4"/>
    <dbReference type="STRING" id="6198.A0A074ZAF4"/>
    <dbReference type="GeneID" id="20325376"/>
    <dbReference type="KEGG" id="ovi:T265_11208"/>
    <dbReference type="CTD" id="20325376"/>
    <dbReference type="OrthoDB" id="1920064at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14413">
        <property type="entry name" value="UBA_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044541">
        <property type="entry name" value="FAF1_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="929"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="992" mass="108958" checksum="686F901072E7DB05" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB37</accession>
    <name>A0A074ZB37_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL597057">
        <property type="protein sequence ID" value="KER20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175808.1">
        <property type="nucleotide sequence ID" value="XM_009177544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB37"/>
    <dbReference type="STRING" id="6198.A0A074ZB37"/>
    <dbReference type="GeneID" id="20325175"/>
    <dbReference type="KEGG" id="ovi:T265_11007"/>
    <dbReference type="CTD" id="20325175"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="83"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="720" mass="77808" checksum="57BD734E00785327" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBA3</accession>
    <name>A0A074ZBA3_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_10955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597049">
        <property type="protein sequence ID" value="KER20505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175741.1">
        <property type="nucleotide sequence ID" value="XM_009177477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBA3"/>
    <dbReference type="GeneID" id="20325123"/>
    <dbReference type="KEGG" id="ovi:T265_10955"/>
    <dbReference type="CTD" id="20325123"/>
    <dbReference type="OrthoDB" id="10376702at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="154" mass="17453" checksum="1A7B0FFD94D4BF9E" modified="2014-10-01" version="1">MFLSKLSQNCCAGSATCCVCRPTDFLEGLFSHNHSGGQPLTWQRSMKEITRRLGAVGATRLPGWGPRDPHCAWLETLQDMAANRCQWRSCCQFLSRLPELPNKSWLYGSEVSVLNTDVMLSMMMMMTWHSGTFELPTDWLSTSAECVWSGEHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCK7</accession>
    <name>A0A074ZCK7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596793">
        <property type="protein sequence ID" value="KER24898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171332.1">
        <property type="nucleotide sequence ID" value="XM_009173068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCK7"/>
    <dbReference type="GeneID" id="20321702"/>
    <dbReference type="KEGG" id="ovi:T265_07523"/>
    <dbReference type="CTD" id="20321702"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="86" mass="9609" checksum="D458B4A6B9B77EAB" modified="2014-10-01" version="1">MHSRPIAESLQSLAIRPSGCVGPPQYEAANVTQFGFQYESTMPIVDLTQTRSDNPNETIPAVMNRTTNHPNLKRTFQTDSYQALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCZ8</accession>
    <name>A0A074ZCZ8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596846">
        <property type="protein sequence ID" value="KER23522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172737.1">
        <property type="nucleotide sequence ID" value="XM_009174473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCZ8"/>
    <dbReference type="GeneID" id="20328791"/>
    <dbReference type="KEGG" id="ovi:T265_14625"/>
    <dbReference type="CTD" id="20328791"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="370" mass="41174" checksum="F52FA189895F0E86" modified="2014-10-01" version="1">MILPSKCTTSSTPACLHIDSVTKRLDLTVVWRLVCLDELLKYIGGVRAILRLSYQARWPKWLEREFTDRKVRGSNPAFATRLPLSRLRQPGSIPALVLPSGGMAARHRKGATAERFLFFLRLLYLRVQSQPQALFKPRKSVRLAAFSVRTLKQAGQQVGVVRTLDSLCIDVCCLSETRTEDASTVIDLAAPLLPSRFRLCTSGDAEAAAAGYTKVGIVLSERAEASLLDWIPSPLCCSATSVRESGGSKVHRTLLIVSAYAPTDCSSESGKKNTQNATSSRNHRISDKTVSLLETRRHIPPDGHYNSTWRIIRRQVKLSVCADGDWWIRKSEEMEDAKNAGNARKLFHLIRPTGLRKSLVIEIIRAKMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDD9</accession>
    <name>A0A074ZDD9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596785">
        <property type="protein sequence ID" value="KER25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171093.1">
        <property type="nucleotide sequence ID" value="XM_009172829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDD9"/>
    <dbReference type="GeneID" id="20321516"/>
    <dbReference type="KEGG" id="ovi:T265_07337"/>
    <dbReference type="CTD" id="20321516"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="10645" checksum="53CD8F13358F29CE" modified="2014-10-01" version="1">MLTELHLYAARIDTTEHLFPPQKRIQAIQHMAPSLVCDCRVRNQQTAKLVLCPQKNVSKTNESFRCQSQVCTYLLRYDVEGERVCRSSTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZDW6</accession>
    <name>A0A074ZDW6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596779">
        <property type="protein sequence ID" value="KER25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170883.1">
        <property type="nucleotide sequence ID" value="XM_009172619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZDW6"/>
    <dbReference type="STRING" id="6198.A0A074ZDW6"/>
    <dbReference type="GeneID" id="20321347"/>
    <dbReference type="KEGG" id="ovi:T265_07168"/>
    <dbReference type="CTD" id="20321347"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047777">
        <property type="term" value="F:(S)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106064">
        <property type="term" value="P:regulation of cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="2">
        <location>
            <begin position="336"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="584" mass="64782" checksum="1B2AF75FC269ED3E" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEI5</accession>
    <name>A0A074ZEI5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_10080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596952">
        <property type="protein sequence ID" value="KER21635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174611.1">
        <property type="nucleotide sequence ID" value="XM_009176347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEI5"/>
    <dbReference type="GeneID" id="20324248"/>
    <dbReference type="KEGG" id="ovi:T265_10080"/>
    <dbReference type="CTD" id="20324248"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="501" mass="55186" checksum="7AAA5BEE6ED85238" modified="2014-10-01" version="1">MQFCALSLQVSRFHDICRSSGKRSSSSIPLKKWSSCSTVYIGDGCLVYPHQETTLWSVAVAIELLARNPKNLELSRLLASDCMYFSHTLASIPSDSMRVYDDVYKLYDERKYSIGCSSENSVAIPKPDFINNPKASDVHGFLRGLFSTALLAPQCAIVALIFLERLINAAEVGLLPWSWRRQLLSCLILASKLLDDQAVWNTDYCQVLRDITVDDLNALERHTLSLLQFNVDVPPAVYARYYFDLLSVGEARGVANQPSERRRLTPELARHLRILPTQPESTTVDTRLLFDLPRTNEPLHSSGTAAAKLESNTLKKASLTIDRQQQVPVSSLDVKPLEFRPQPSDPYVSIPVAPHLSSSTSSQLHSPPDWTPGLSTDPLTDNEPLALDDETEFINGLTLSSLLTSVPRFPASPNDGVCDTAPSSHSTFSPQSIPHVQLNPTTHPRNTNTVPGQRFATHCGAPTDTSTTTIYNPVGNNGTGFIRSIMGGEVAYSLLRDAGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEQ7</accession>
    <name>A0A074ZEQ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596766">
        <property type="protein sequence ID" value="KER25776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170450.1">
        <property type="nucleotide sequence ID" value="XM_009172186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEQ7"/>
    <dbReference type="STRING" id="6198.A0A074ZEQ7"/>
    <dbReference type="GeneID" id="20320991"/>
    <dbReference type="KEGG" id="ovi:T265_06812"/>
    <dbReference type="CTD" id="20320991"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000021">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="278" mass="30615" checksum="37E9FCE80E0388DB" modified="2014-10-01" version="1">MADPDYYAVLSVSRDATSDDIKKAYRRLALKWHPDKNPDNKDYAEHRFKLISEAYEVLSDQSKRRVYDQYGKQGLVNGGATSHGTYAGEFDPFAFHPFQFHFRDPMDIFREVFGGFGLDSLFGPSLFMGLDPSNPSNRAHRSTSHRATNRHSGSPYHHAQHPTRSASHRSDLAVPSENDFMGGLFDFFGGSMLQPFGMFGAPDFGNAISSSTVFGNFGGVPVSGGYRSVSTSSRTVNGRTVRVTKVVENGTETITEEVDGRVTTRTTRPHGGGALQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZES1</accession>
    <name>A0A074ZES1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596770">
        <property type="protein sequence ID" value="KER25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170619.1">
        <property type="nucleotide sequence ID" value="XM_009172355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZES1"/>
    <dbReference type="GeneID" id="20321131"/>
    <dbReference type="KEGG" id="ovi:T265_06952"/>
    <dbReference type="CTD" id="20321131"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="274" mass="31565" checksum="BAE7E85EE98C599C" modified="2014-10-01" version="1">MTAPVIRFVFRNDDEYVGALKIDEGLNNNNLNTGIWKTFWCSPHHFIDDKMNKDEDDCYGSVTQRANNMIMRIVAILYPQLCCLIQTPSTANSKKTKTSDTNFNNPTTHDQQAMPGASEPKDGLTARTYFVDPTPKREALDSSFALIRAYQLCLAISSGRLMREFLMFLLLINDLYYEVYVPMQCIVYDGSENNHRIDRDFYDPVSKIEMSSETFMPELDFTIHDQNYGLEFPEEGCNHTRPSCPIKNGVRYTTDLNLRMPDILIEFDNRQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFH2</accession>
    <name>A0A074ZFH2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171873.1">
        <property type="nucleotide sequence ID" value="XM_009173609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFH2"/>
    <dbReference type="GeneID" id="20322123"/>
    <dbReference type="KEGG" id="ovi:T265_07944"/>
    <dbReference type="CTD" id="20322123"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="85" mass="9633" checksum="54E8108F647E11FF" modified="2014-10-01" version="1">MGHKKSSVWRSTGRLWHDFLIQLCQSHCILVYLLSTAGPSTHGQVEVISTNETALPRKSQCNTQRETPSNDLRFAATIWSRKLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFH3</accession>
    <name>A0A074ZFH3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_06691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596761">
        <property type="protein sequence ID" value="KER25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170289.1">
        <property type="nucleotide sequence ID" value="XM_009172025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFH3"/>
    <dbReference type="STRING" id="6198.A0A074ZFH3"/>
    <dbReference type="GeneID" id="20320870"/>
    <dbReference type="KEGG" id="ovi:T265_06691"/>
    <dbReference type="CTD" id="20320870"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="196" mass="22472" checksum="568383FAE3425FF1" modified="2014-10-01" version="1">MGSELQIVDTPSQDKENVFDGMDNAVTQIREQCEFYFSDANILKDQFMLNQVKSSTDGWVKLGIIEKFKKVQRLTQDHSVVVHALSMSSKLELSEDGLSVRRRDPLPSWDPSVYHRTIILTDLPEDVELNHAKVTELFTLFATDIGWYQQGNLEMGSAAETFVVENIQQHQLRWLDHVLRMPEHRLSRLVLSSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFN4</accession>
    <name>A0A074ZFN4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER26091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009171874.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20320750"/>
    <dbReference type="KEGG" id="ovi:T265_06571"/>
    <dbReference type="CTD" id="20320750"/>
    <dbReference type="OrthoDB" id="10409064at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Snake toxin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704127" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21644" checksum="7B845EDCCE64BFF2" modified="2014-10-01" version="1">MVVYCTAFCLLIFGLFSTGEWKNSSYQYWVLVTALKCFDCAKCPENPKEGEVPVKTNCKTCLLDCEGFITNRGDIISAGLSATYVHNIARKLTFRFSLWLIPQLSSNKSHSLFLLDECKKYTSRTYSGRKLRALSITCSPVCPPTKGVDAGSLVTVKVKCCYRDLCTGHAVSRIPSAIMTLICLLILHLFCPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER24522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009173467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFV0"/>
    <dbReference type="GeneID" id="20322013"/>
    <dbReference type="KEGG" id="ovi:T265_07834"/>
    <dbReference type="CTD" id="20322013"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="63" mass="7005" checksum="32FC2ED86502CF52" modified="2014-10-01" version="1">MSITSGYEDRGRWNGTTKSATSATSYMNGLSLSERIELGYETEKTGCTWGNSEEDDALILQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGQ4</accession>
    <name>A0A074ZGQ4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_09472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KER22425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009175552.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZGQ4"/>
    <dbReference type="GeneID" id="20323641"/>
    <dbReference type="KEGG" id="ovi:T265_09472"/>
    <dbReference type="CTD" id="20323641"/>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="332"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="424"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="530"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1992"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2020"/>
            <end position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER22425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2039" mass="224754" checksum="307234C2950D974F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGT0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009171568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGT0"/>
    <dbReference type="STRING" id="6198.A0A074ZGT0"/>
    <dbReference type="GeneID" id="20320517"/>
    <dbReference type="KEGG" id="ovi:T265_06335"/>
    <dbReference type="CTD" id="20320517"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="225" mass="25884" checksum="015DFCAE466B0294" modified="2014-10-01" version="1">MFQPLRYSRCRLETSKPRDSAGFQVSLPQNRICLRMSVFHQFRAIWFQLVHKVDGNSGDAPTRWAPREAKPLAGCRGVFSNIMSSALQADLKAASFSKFLLNLYSASITLMVCELPHCCMGFRQTADQSDEGLNSRHVQIVGTIFEISQYIFIKETSHKVAEKSWTADDRFRPSWGSSGRRSFRVSVNLMFYFNPNYTFFEKYTHSQINLVFTRDSTESLVYDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHE4</accession>
    <name>A0A074ZHE4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_06146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596742">
        <property type="protein sequence ID" value="KER26643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169603.1">
        <property type="nucleotide sequence ID" value="XM_009171339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHE4"/>
    <dbReference type="GeneID" id="20320328"/>
    <dbReference type="KEGG" id="ovi:T265_06146"/>
    <dbReference type="CTD" id="20320328"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER26643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="354" mass="39494" checksum="32E031C790597F56" modified="2014-10-01" version="1">MRPKRNDAAIDNAHNEEAPAGEDEPLNVLQSDGVETEDTDEEDNEEERFRTLSSEDDDEPESCRTCLWERERDSGVERIIEPGDPEILSEKIDGQKVRAEEDDEVEPRDDVLGDRALRFFAAFGLEDDDQPWWAFAPLACSAERTLEGEDGCFARISCGTAPSGCSTGGTVEETSAEDDAVKRTHRNGVHLDLLKTWWHNRNSKKTSGWKYSIHLNKGDSRAASTTIFSCSGCTPSTAHSYRPQEAESTRLLKCISTPEPPADEQMLQQRTDDNSTHRRRINDLPSGCVHNAMFLGRDRLFLSRGDSGTQSSVPTTVIPRNGRDVCTIQFLGLPTFKSKQLIAEPYEVGQNKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZHQ5</accession>
    <name>A0A074ZHQ5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_09195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596880">
        <property type="protein sequence ID" value="KER22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173471.1">
        <property type="nucleotide sequence ID" value="XM_009175207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZHQ5"/>
    <dbReference type="STRING" id="6198.A0A074ZHQ5"/>
    <dbReference type="GeneID" id="20323374"/>
    <dbReference type="KEGG" id="ovi:T265_09195"/>
    <dbReference type="CTD" id="20323374"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="779" mass="84809" checksum="E1FB2A952693D40D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIZ7</accession>
    <name>A0A074ZIZ7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596854">
        <property type="protein sequence ID" value="KER23315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172920.1">
        <property type="nucleotide sequence ID" value="XM_009174656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIZ7"/>
    <dbReference type="STRING" id="6198.A0A074ZIZ7"/>
    <dbReference type="GeneID" id="20322943"/>
    <dbReference type="KEGG" id="ovi:T265_08764"/>
    <dbReference type="CTD" id="20322943"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="329" mass="33197" checksum="0FFEAFF086796E7F" modified="2014-10-01" version="1">MRISTGSHLVTDVQPENEDRLKQLQLMELAVLNDKDRQQAQAHQAQQQQQQQQQQQLLLQHQSLLSNPAAAAAAAAQLLHTSSSAQTTSQLLARLQASPIGISSLNAAALQLNPGIAAGITGSTAALQAAAAAAAAAAAGGSGAALPFSTMTSLASYLSSPGLTASPIQAASASNLGTATGGSAIGLPLSQLPCTTATGLGFSTLPFSVNPGLPTSGSTNLINCTPGSAQDQYTALAAALLSGGTNNTSNNNTAAAQMSNGKVPVSAGSSKPSTSYYPMTSLASSLVDPVTIIEYNSANSVAAAQEMASDSLKLRSISSGQNRMHPYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKB1</accession>
    <name>A0A074ZKB1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596754">
        <property type="protein sequence ID" value="KER26177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170078.1">
        <property type="nucleotide sequence ID" value="XM_009171814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKB1"/>
    <dbReference type="GeneID" id="20320710"/>
    <dbReference type="KEGG" id="ovi:T265_06531"/>
    <dbReference type="CTD" id="20320710"/>
    <dbReference type="OrthoDB" id="6229751at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="292" mass="33722" checksum="BA9195925A6ACD61" modified="2014-10-01" version="1">MIRQRFEPNEHKSFLATSERKKASAAELLDREAKLSYASCLQKLNIHPLFERVFLNFSGYSLTVAQIQANATKRLHKFRNRFYFSRDAKRIYKKTYYSRVSPISSTTVTPGICRRLGRSLRWLDHVLRMPVDRLPQRALFAQPREGWNRVRGGQTMTWQRSMKAITSKLSCAGNCRLPEWGTRDGPDQWLETLSDMAQSRPQWRSSFSNPPLDNPLTLLDLRTNLSAPACNAQLSIPPPDRRSMLIHIHMRGPNILNIYLVQVVPYSTQLNSFSRSILSVPSCHANRRRHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKL4</accession>
    <name>A0A074ZKL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596830">
        <property type="protein sequence ID" value="KER23900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172349.1">
        <property type="nucleotide sequence ID" value="XM_009174085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKL4"/>
    <dbReference type="GeneID" id="20322498"/>
    <dbReference type="KEGG" id="ovi:T265_08319"/>
    <dbReference type="CTD" id="20322498"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="212" mass="23498" checksum="98DF0AB5D8DB9228" modified="2014-10-01" version="1">MVARQSLRETFNTINCVGWAVCYACQDTVYRNECCSPSQLPNGASHEIDTAWRHCKRGRMVDVSSVHIVGFFSDCLIEHLQVSVVRIRPPPLDFPCLGLGNLAVSQPSCFLRVAWQLGTGRVLQLNTILHLKKGEALCTQTVVSSVQIRNRYGVCITYWKPENIAGMLGQPGSIPDLVLPSGGMAARHRKGATAERLHRHLPRVKCMANNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL39</accession>
    <name>A0A074ZL39_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596715">
        <property type="protein sequence ID" value="KER27776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168497.1">
        <property type="nucleotide sequence ID" value="XM_009170233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL39"/>
    <dbReference type="STRING" id="6198.A0A074ZL39"/>
    <dbReference type="GeneID" id="20319446"/>
    <dbReference type="KEGG" id="ovi:T265_05264"/>
    <dbReference type="CTD" id="20319446"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24044" checksum="CC9D6E5E3D0CBE3F" modified="2014-10-01" version="1">MHKAVTVTIRILSDVLAFVVSMGVLQRIQPISQGYFADDYSIRLPRHSSTVSSVTLYSVSSVLILTTVVAVEVMIGWDSLRMKKAGIPVVLYSIYDYLLVAFYGYFVTITITDVGKAAVGRLRPSFFDQCGPNVLQSTVLGYITDYSCTSGSEKDHLDARIPTNRTSLVNIRMLDAAEAAARRLRNPVPCVQNLEVNRHEFVDLKTAHPVSQMSSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLR2</accession>
    <name>A0A074ZLR2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5736 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169582.1">
        <property type="nucleotide sequence ID" value="XM_009171318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLR2"/>
    <dbReference type="GeneID" id="20328119"/>
    <dbReference type="KEGG" id="ovi:T265_13952"/>
    <dbReference type="CTD" id="20328119"/>
    <dbReference type="OrthoDB" id="6241682at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043794">
        <property type="entry name" value="DUF5736"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19007">
        <property type="entry name" value="DUF5736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5736" evidence="2">
        <location>
            <begin position="187"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="454" mass="51087" checksum="2A4A0099C376B928" modified="2014-10-01" version="1" fragment="single">MQLQEQLYEGLPSNGAHSDDKVRRRPFGQNLRNRLNTIVSMYIPSQASVERKNDESTCEHAELLSATDAKVDLAPKMFDELYSIQLLYSGEDLVRSIVEGIGTPMSTSTGTTRKITSIAADDHTLYACLEELPYVFLLKAHLESQVCELDGTLRRRELSPIKGYIQLHVPGIGDLVPQELSVYSPTPESTVMYIVGWVRIIVDPKNYTTEKRWLLAKFSLAGQHLARTPVYSYQRYSGVAIDTHDGSLLLAFPQLKEQSTNSHDCTTAQLCKLTQGFERRIFSVTMGNNVATYRPDFVSQESAGRFCWASVQRTPRSDGTQATNEQVTSTSRRLFSFPGRQLEGGEKKQSAREWLQVMSWDFADLTPGRIVAFDADRLLVVDANTGSLSYVTWQQGHDRPTLHRITRPHSKPISLICSNYKVAHGEQEIVSNIAYFVSGSSIYSFSFREDYVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM08</accession>
    <name>A0A074ZM08_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596811">
        <property type="protein sequence ID" value="KER24405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171843.1">
        <property type="nucleotide sequence ID" value="XM_009173579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM08"/>
    <dbReference type="STRING" id="6198.A0A074ZM08"/>
    <dbReference type="GeneID" id="20322098"/>
    <dbReference type="KEGG" id="ovi:T265_07919"/>
    <dbReference type="CTD" id="20322098"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER24405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65704" checksum="6A0B05C60D59E597" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZN93</accession>
    <name>A0A074ZN93_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Arginine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_07596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596796">
        <property type="protein sequence ID" value="KER24810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171424.1">
        <property type="nucleotide sequence ID" value="XM_009173160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZN93"/>
    <dbReference type="STRING" id="6198.A0A074ZN93"/>
    <dbReference type="GeneID" id="20321775"/>
    <dbReference type="KEGG" id="ovi:T265_07596"/>
    <dbReference type="CTD" id="20321775"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="86"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="10">
        <location>
            <begin position="417"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="420"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="578"/>
            <end position="582"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="607"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="73488" checksum="260411564F30F4D3" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNN7</accession>
    <name>A0A074ZNN7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596724">
        <property type="protein sequence ID" value="KER27402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168891.1">
        <property type="nucleotide sequence ID" value="XM_009170627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNN7"/>
    <dbReference type="GeneID" id="20327982"/>
    <dbReference type="KEGG" id="ovi:T265_13815"/>
    <dbReference type="CTD" id="20327982"/>
    <dbReference type="OrthoDB" id="6245587at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704261" evidence="1">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER27402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="233" mass="26244" checksum="E962EA6190A3298F" modified="2014-10-01" version="1">MDLANILTLGFPNILAFLLTIHPQNNLHQSYLCICVDISAAEHCERGSCSESAYGLHSKRSCVEKPLDSSPWYKPNGFGQLGQYSLHLPNEPAFVHWFSRVHLGRRFADLIIVDGLEGLFSPDRMRASDVLRLTSLLEDTRNFIDTSTNPEDHGHGCRLLVTCCLPVQSSDSTHSPTIPVHSLEETFIFSEDSTNCYSILGQKDRWKLNLEYVEGELFWKTFHPPPNVAAIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNY1</accession>
    <name>A0A074ZNY1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596789">
        <property type="protein sequence ID" value="KER25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171212.1">
        <property type="nucleotide sequence ID" value="XM_009172948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNY1"/>
    <dbReference type="GeneID" id="20321609"/>
    <dbReference type="KEGG" id="ovi:T265_07430"/>
    <dbReference type="CTD" id="20321609"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="6783" checksum="FDBCD5F4B0136A20" modified="2014-10-01" version="1">MVEKPGPADLFGHGITSIPLQQLVFDDKVEDCSDCARNRALASVAEPESFWNELQHQKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR11</accession>
    <name>A0A074ZR11_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAAX prenyl protease</fullName>
            <ecNumber evidence="9">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_13631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="9"/>
    <dbReference type="EMBL" id="KL596704">
        <property type="protein sequence ID" value="KER28247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168050.1">
        <property type="nucleotide sequence ID" value="XM_009169786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR11"/>
    <dbReference type="STRING" id="6198.A0A074ZR11"/>
    <dbReference type="GeneID" id="20327798"/>
    <dbReference type="KEGG" id="ovi:T265_13631"/>
    <dbReference type="CTD" id="20327798"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="10">
        <location>
            <begin position="238"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER28247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="472" mass="54112" checksum="9689E70DAF691979" modified="2014-10-01" version="1" fragment="single">MEVIVLGSIFGYPVSLFAAVFCFLWLVYLWETYLDRRQRQVVLNTSDVPSELVHVINADEFSKSKAYVLDKMMFSFFHDAYDMLEATLVLWFSVVPWLWDKVTEHAAPLNKSIKNLLGVDIGLSSESEILCSLLFLFYVSLYKFFESLPWALYYDFVIEARYGFNKQTLPFFLWDRLKAFVLSILIGFPIVSGLIWIIKAGGRHFYVYAYVFTLIITLFLMFIYPEFIAPLFDRYVPLPEGELRTKIEALAAKISFPLKKLLVVEGSKRSAHSNAYFYGFGKNKRIVLYDTLIRGFKFPAKDGSTSKASGETDEASRGCAIDEEIVAVLGHELGHWKLGHTLINLAISQLNLFLMFLVFSSLINIDSIFTSFGFTSNVPVLLRLVVVFQFIFSPYNTVVAFLMIILSRRLEFQADRFAVDLGYGAYLKSALLVLHKDNLSFPVSDWLYSTFHYSHPPILERLAALDVLLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR65</accession>
    <name>A0A074ZR65_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166376.1">
        <property type="nucleotide sequence ID" value="XM_009168112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR65"/>
    <dbReference type="GeneID" id="20317780"/>
    <dbReference type="KEGG" id="ovi:T265_03593"/>
    <dbReference type="CTD" id="20317780"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="82" mass="9164" checksum="52E1C704F8238B3A" modified="2014-10-01" version="1">MDTSVRVQGTSILKRKRPRSNGPTSKVKMNIRKPSRATEDLTGERIAGLASRFRQWKRKQKGIPVTDAAVQCKPPDTLVNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZS74</accession>
    <name>A0A074ZS74_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009167709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZS74"/>
    <dbReference type="STRING" id="6198.A0A074ZS74"/>
    <dbReference type="GeneID" id="20327359"/>
    <dbReference type="KEGG" id="ovi:T265_13192"/>
    <dbReference type="CTD" id="20327359"/>
    <dbReference type="OrthoDB" id="6271780at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="907" mass="99280" checksum="1E4B8FEEA9BA0212" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSM0</accession>
    <name>A0A074ZSM0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_06350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596749">
        <property type="protein sequence ID" value="KER26365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169855.1">
        <property type="nucleotide sequence ID" value="XM_009171591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSM0"/>
    <dbReference type="GeneID" id="20320532"/>
    <dbReference type="KEGG" id="ovi:T265_06350"/>
    <dbReference type="CTD" id="20320532"/>
    <dbReference type="OrthoDB" id="448087at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER26365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="117" mass="13292" checksum="B89308964F1D6789" modified="2014-10-01" version="1">MVMESDNREVTIISIFSEVTLAWRIKLEQRRQEAELLAELEESIPSRLITTLTTFSDAQLYADRRTRITAALHSAGLLDSDYARTLLSGVQPTVPPRKDSQTCEQLKQMLNPQSEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTA6</accession>
    <name>A0A074ZTA6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Signal recognition particle 68 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_03194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165877.1">
        <property type="nucleotide sequence ID" value="XM_009167613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTA6"/>
    <dbReference type="STRING" id="6198.A0A074ZTA6"/>
    <dbReference type="GeneID" id="20317381"/>
    <dbReference type="KEGG" id="ovi:T265_03194"/>
    <dbReference type="CTD" id="20317381"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000001">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="748" mass="83406" checksum="EFCAE0A08726A498" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV63</accession>
    <name>A0A074ZV63_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_02406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164903.1">
        <property type="nucleotide sequence ID" value="XM_009166639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV63"/>
    <dbReference type="GeneID" id="20316594"/>
    <dbReference type="KEGG" id="ovi:T265_02406"/>
    <dbReference type="CTD" id="20316594"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="72" mass="8420" checksum="842FD41D3F541877" modified="2014-10-01" version="1">MSRDHKQDHRCLVHTSTLLLMPKLSSANRAFNQRFSPLEPALIGQKNQSSVRKRWRAIHDANFEQRPLDTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVY9</accession>
    <name>A0A074ZVY9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIK-related kinase FAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_15568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597236">
        <property type="protein sequence ID" value="KER19354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176900.1">
        <property type="nucleotide sequence ID" value="XM_009178636.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZVY9"/>
    <dbReference type="GeneID" id="20329733"/>
    <dbReference type="KEGG" id="ovi:T265_15568"/>
    <dbReference type="CTD" id="20329733"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK-related kinase FAT" evidence="2">
        <location>
            <begin position="3542"/>
            <end position="3637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2374"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2759"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3410"/>
            <end position="3431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3502"/>
            <end position="3527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3862"/>
            <end position="3933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3949"/>
            <end position="4067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4184"/>
            <end position="4264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5061"/>
            <end position="5084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2374"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2393"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2405"/>
            <end position="2420"/>
        </location>
    </feature>
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</entry>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
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                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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            <position position="686"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KER19564.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZWL6</accession>
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        <name type="scientific">Opisthorchis viverrini</name>
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        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596640">
        <property type="protein sequence ID" value="KER31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164346.1">
        <property type="nucleotide sequence ID" value="XM_009166082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZWL6"/>
    <dbReference type="STRING" id="6198.A0A074ZWL6"/>
    <dbReference type="GeneID" id="20316132"/>
    <dbReference type="KEGG" id="ovi:T265_01944"/>
    <dbReference type="CTD" id="20316132"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="189" mass="19789" checksum="471395513793E167" modified="2014-10-01" version="1">MPSEICPKCQKAVYAAEKKIAGGKAWHSMCLKCGLCNKMLDSTTVAEHEGEVFCKQCHGRKFGPKGYGFGGGAGALNMDSGAHLGNVGTEMSNKPTTAGTGGAVIPPEQGGCPRCGKRVYDAEKAIGCPSGLNFHKACFRCKTCGKSLDSTTLCTQKEEQEIYCKGCYGKHFGPKGFGFGQGAGVLNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXB6</accession>
    <name>A0A074ZXB6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C13 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_05045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER27995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168220.1">
        <property type="nucleotide sequence ID" value="XM_009169956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXB6"/>
    <dbReference type="MEROPS" id="C13.007"/>
    <dbReference type="GeneID" id="20319227"/>
    <dbReference type="KEGG" id="ovi:T265_05045"/>
    <dbReference type="CTD" id="20319227"/>
    <dbReference type="OrthoDB" id="9973749at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF42">
        <property type="entry name" value="LEGUMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER27995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40356" checksum="F7911EAEA36A0AB2" modified="2014-10-01" version="1">MSTILSRNPFKGQVFNDYEHEDFYKGVVIDYRGKNPSDHFNHQLDKTVYVTMGLLQLMTKPIFLGNITIEIPFPRLFCALLCARVPPDKLLSKTILTFPFNSSGPDDNVFIYYTGHGSRYYIIFPDEELTVVELNNIFAHLRSKKKYNKLVFYMDACFSGSMFGSLPSNVGIYATTSAKEDEDSYAVHCDDKQIDVCLATEYSYAWITDSEYVSFIKNVADEPVSLDSKPSSWVHLISMSRRLMEATTVEEHEAAWRKLHRALQLGHIVKETFHDIVMDVTSHHKPTVKGLSTRNELMCFKAVFDHFRTHCFTIQQATSVQHWCYAVVDDDDEYEDDDDDDDKGGDYDDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXL4</accession>
    <name>A0A074ZXL4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168155.1">
        <property type="nucleotide sequence ID" value="XM_009169891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXL4"/>
    <dbReference type="GeneID" id="20319183"/>
    <dbReference type="KEGG" id="ovi:T265_05001"/>
    <dbReference type="CTD" id="20319183"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="12814" checksum="CEB863EFCFCAA2F7" modified="2014-10-01" version="1">MYVGMCQQKGCSFERSVCSRKFSLGQRRAFLGVCVCTTSFSSQSQNFYMTFTIPQPDVLLPKVLVSCSTLSVSSCHATRRRHEGWDTARSPKSRQGKSSGKGRVRTIGLPVSKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZXT5</accession>
    <name>A0A074ZXT5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deltamethrin resistance protein prag01 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165423.1">
        <property type="nucleotide sequence ID" value="XM_009167159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZXT5"/>
    <dbReference type="GeneID" id="20317003"/>
    <dbReference type="KEGG" id="ovi:T265_02815"/>
    <dbReference type="CTD" id="20317003"/>
    <dbReference type="OrthoDB" id="6219829at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031973">
        <property type="entry name" value="Deltameth_res_prag01"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16020">
        <property type="entry name" value="Deltameth_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Deltamethrin resistance protein prag01" evidence="2">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="286" mass="31904" checksum="D6ED773EEF848562" modified="2014-10-01" version="1">MPEYMSKNPAINVSKILSSDTASHLLYCSRNKGPGELLKPNFQGDQSPIALHCSGIDATLPVVLGVANVRHHGGHVPMRFPNGTYDEIPIPSGDWAKTYKERNTFYNQFMVGWTLCTLVLAVIAYRVADVHKYSLSPSENTEEGLKFMKPDKEALKLNSRIDTQDRGFCPSFPFRFCSCRSVAVVHLKGTSEKRKERGQPSEEGHSTQLLPELRKKICLMNVYTQLENLTMSHRMFAGSTVASEVMVLQGKEHRETRFIVHGFKAGNHSRSGSLDTVGEGDVFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZYE6</accession>
    <name>A0A074ZYE6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_02692</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596652">
        <property type="protein sequence ID" value="KER31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165258.1">
        <property type="nucleotide sequence ID" value="XM_009166994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZYE6"/>
    <dbReference type="STRING" id="6198.A0A074ZYE6"/>
    <dbReference type="GeneID" id="20316880"/>
    <dbReference type="KEGG" id="ovi:T265_02692"/>
    <dbReference type="CTD" id="20316880"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER31017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="375" mass="41496" checksum="C3A84C5340D993BE" modified="2014-10-01" version="1">MGALLSTPKTEKYNETGSGNGLRYGISSMQGWRITMEDAHCAITQLPGNLKDWSFFAVFDGHAGALVSAMCASELLKCIVDTEEFKKVNPDLAPSIPEIERGIRDGFLALDERLRQLPQLASGEDKSGSTAVCVLITPKHIFFANCGDSRAVLIREGSVAFATVDHKPINPTEKERIQNAGGSVIIERVNGSLAVSRSLGDYAYKTAKGLGPTEQLISPEPEITVLDRDKVMDQIIVLACDGIWDVLSSDALCSLLQHRMRCSDDLSVVCNEIIDMCLYKGSSDNMSIVLVAFDPSPRAEAKYKKEDEELEQLILQRAKDFLEKSDRMPSMEIMLNHLQDFTEPELPPFLVYCKSGKIRRLLEEHQCNGQNHSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A083</accession>
    <name>A0A075A083_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Disintegrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_01230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KL596631">
        <property type="protein sequence ID" value="KER32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163479.1">
        <property type="nucleotide sequence ID" value="XM_009165215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A083"/>
    <dbReference type="STRING" id="6198.A0A075A083"/>
    <dbReference type="GeneID" id="20315418"/>
    <dbReference type="KEGG" id="ovi:T265_01230"/>
    <dbReference type="CTD" id="20315418"/>
    <dbReference type="OrthoDB" id="2131567at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF6">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="73"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="3">
        <location>
            <begin position="225"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40866" checksum="0F293B2E1BA25D7B" modified="2014-10-01" version="1">MEKTFATGNSLALYQRIRSTDPRKAMVSETIREKDGSSVHSQKRRLERWAEHFEEQFSWLLATQPVEILHTDEWNAFSYAQFNRTCLAHLLTYLPFMGVLGRAWTAAPELGGICSPSGTERGEEFKMNTGWTTYADYSGRRLLNAMAELITAHELGHNWGAAHDPDTEECSPPAHSRGKYLMYAHSVAGFAVNNYRFSPCSRRTIGATLAARAPLCFVATSESTVRLCGNRRLDPGEECDAGVVHDDVCCTDNCKLRHGAQCSPWNHDCCTSACQVAPPSTQCSERNSGNPCLSPGTCDGKSASCPGPTRLSGVPCAEHGQCIQGKCRTQCERLGLHTCICDEVYSMPCDSSSKLREGSRPAACFLYSAIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A091</accession>
    <name>A0A075A091_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_04276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596687">
        <property type="protein sequence ID" value="KER28980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167239.1">
        <property type="nucleotide sequence ID" value="XM_009168975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A091"/>
    <dbReference type="STRING" id="6198.A0A075A091"/>
    <dbReference type="GeneID" id="20318458"/>
    <dbReference type="KEGG" id="ovi:T265_04276"/>
    <dbReference type="CTD" id="20318458"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER28980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="178" mass="19685" checksum="16ADB3A3504682D8" modified="2014-10-01" version="1">MPTAMSSGIPAQLGGGVSACSPMPTQYIGTPNPAAGVAANRMATVAHLRSPAGGRVRTKTVKKASRFIIERFYGRLTRDFHTNKKVCQDIACINSKRLRNKIAGYVTHLMKRLETGNVRGISVKMQEEERERRDNYQPEISHFDTIGAELDPVTQEMLQSMNIPHAKNLRAIQPLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0M8</accession>
    <name>A0A075A0M8_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_00933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596627">
        <property type="protein sequence ID" value="KER33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163092.1">
        <property type="nucleotide sequence ID" value="XM_009164828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0M8"/>
    <dbReference type="GeneID" id="20315121"/>
    <dbReference type="KEGG" id="ovi:T265_00933"/>
    <dbReference type="CTD" id="20315121"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="194" mass="21749" checksum="2774D0B39ADB70B9" modified="2014-10-01" version="1">MVVGLFAELGNLVANVSSPIEGTSSMRSCAWRWVCGCAQPHALMMSPRLVMKRLQPNCPAQRTSQRPSTLPELPTFSSIENKGYFLYDTLLIGPQERWCIGLIWFFERLTWNPAESLVCDVLRQLNVPHQAASCLSRYDIQDIATHPSLAIYLKTSCHHTGRHHQCADSDDVFLTADETFARQLPSLANRSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Q1</accession>
    <name>A0A075A0Q1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596629">
        <property type="protein sequence ID" value="KER32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163241.1">
        <property type="nucleotide sequence ID" value="XM_009164977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Q1"/>
    <dbReference type="GeneID" id="20315222"/>
    <dbReference type="KEGG" id="ovi:T265_01034"/>
    <dbReference type="CTD" id="20315222"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7240" checksum="0E3F0FD10E891CF8" modified="2014-10-01" version="1">MEDEMIGPELGTILSKDSPTLLGSKAKVKSHAMGHVTPISHRPIAYSRLHALVAAQQGKQSHGHSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A0Z8</accession>
    <name>A0A075A0Z8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_00716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596625">
        <property type="protein sequence ID" value="KER33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162829.1">
        <property type="nucleotide sequence ID" value="XM_009164565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A0Z8"/>
    <dbReference type="GeneID" id="20314904"/>
    <dbReference type="KEGG" id="ovi:T265_00716"/>
    <dbReference type="CTD" id="20314904"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="446" mass="51500" checksum="892409502BD3AA6B" modified="2014-10-01" version="1">MSIHKERMASAARTVRPNKPRIESNPKLNATTTHNVEIWSATLVQPTVCFMGTILNILNFIVFRQRQFTATPYLYMSALAIADAGTLLVYLPTGITKCDRRIPICVLPFTKDLRTFLSYYHTYVGFGLGNIFEAMSSWITVLICIERYVIMRWPHLGKLHFSRRAARCQIICTICFVILFHLPMFFALKIERGEFVTGNNTSKRYLKMGMTWFGHSMYYYIITWVRFICIQCIPLALLCVVNLRLLILIWSNYRKQRMHSVHIDNGDDMMKREEFLSSIIEHQSEIVTQLSPDYADRERSKGYRAERVESLQVPRLCPVGSNHLRKHSSSIPNAAFYGSSSSLIQQGRIDKKPHSVAAIELDFQDGRRKADCIYKLTVKVLRQTNNWIPNYIDGAVTPQVFLMEVATVYAYLRFTIDACDASRGYGRNIGMICHYHCLRRQNREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A1Q7</accession>
    <name>A0A075A1Q7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_01764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596637">
        <property type="protein sequence ID" value="KER32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164118.1">
        <property type="nucleotide sequence ID" value="XM_009165854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A1Q7"/>
    <dbReference type="GeneID" id="20315952"/>
    <dbReference type="KEGG" id="ovi:T265_01764"/>
    <dbReference type="CTD" id="20315952"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="17762" checksum="108D3FC7BC837A75" modified="2014-10-01" version="1">MMNSRCSMENTADYSRYCSGIRSLINTSRRTQDTVTKRLDLIVVWRRCLLSSTGLCGFKSISTVLDNAPVVTVNRWALGVCGFWGRPFLTRPSGRQGSNAASMNMDMLVACGKHLPSHSCRRCLAATPPEGSTRAGMAPGCPSLDTKSRDTEIGFEAQTFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A269</accession>
    <name>A0A075A269_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596622">
        <property type="protein sequence ID" value="KER33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162509.1">
        <property type="nucleotide sequence ID" value="XM_009164245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A269"/>
    <dbReference type="GeneID" id="20314660"/>
    <dbReference type="KEGG" id="ovi:T265_00472"/>
    <dbReference type="CTD" id="20314660"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="75" mass="7967" checksum="008172D8EF1B8C1F" modified="2014-10-01" version="1">MCLAWLTDCNRVSSAPDQRTAISSACSISVSKYPGGISNPQELEGVDHGSDPRSDHMEGEVEEEGWKGTALLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A3K7</accession>
    <name>A0A075A3K7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KL596926">
        <property type="protein sequence ID" value="KER21984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174272.1">
        <property type="nucleotide sequence ID" value="XM_009176008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A3K7"/>
    <dbReference type="STRING" id="6198.A0A075A3K7"/>
    <dbReference type="GeneID" id="20329128"/>
    <dbReference type="KEGG" id="ovi:T265_14962"/>
    <dbReference type="CTD" id="20329128"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000270">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="80"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER21984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="513" mass="57533" checksum="32682C2680FD3B8B" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5B2</accession>
    <name>A0A075A5B2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_02822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596655">
        <property type="protein sequence ID" value="KER30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165430.1">
        <property type="nucleotide sequence ID" value="XM_009167166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5B2"/>
    <dbReference type="STRING" id="6198.A0A075A5B2"/>
    <dbReference type="GeneID" id="20317010"/>
    <dbReference type="KEGG" id="ovi:T265_02822"/>
    <dbReference type="CTD" id="20317010"/>
    <dbReference type="OrthoDB" id="514167at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019265">
        <property type="entry name" value="RTRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15924">
        <property type="entry name" value="CLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10036">
        <property type="entry name" value="RLL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704540" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="110" mass="12284" checksum="ACD4CAC76443D902" modified="2014-10-01" version="1">MMFKVSFPNVMLSYFLKAVCLLIEQKLSSQSIERAIAEYGTVKIDQLKVPEVCLGFEISDPELRAAAVALRLLNVNEMRRLQDLANAAVVQVQRLTADPKTDEKLGKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5H6</accession>
    <name>A0A075A5H6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596654">
        <property type="protein sequence ID" value="KER30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165412.1">
        <property type="nucleotide sequence ID" value="XM_009167148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5H6"/>
    <dbReference type="GeneID" id="20327259"/>
    <dbReference type="KEGG" id="ovi:T265_13091"/>
    <dbReference type="CTD" id="20327259"/>
    <dbReference type="OrthoDB" id="6272694at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="258" mass="28942" checksum="B34558659609402C" modified="2014-10-01" version="1" fragment="single">MALCNIHEEIREEQMEWCSILGPYIPLAVLGIVLSEQAEASLLDWMPVDSRLCAVRLATSVRESRESEVHRTLFIVSAYTPIDCSSESAKDSIYKAVLGIVLSEQAEASLLDWMPVDSRLCAVRLATSVRESRESEVHRTLFIVSAYTPIDCSSESAKDSIYKVLGALLQQAKSSDIVVLASDMNVKRCRGLIGWSSWFGHEKHGHRRPVTSNVCRSQTIPLQYEFPEQRTSLDNLVPTNKPAPNPHRPHRRQLSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A5X2</accession>
    <name>A0A075A5X2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596623">
        <property type="protein sequence ID" value="KER33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009162632.1">
        <property type="nucleotide sequence ID" value="XM_009164368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A5X2"/>
    <dbReference type="GeneID" id="20314752"/>
    <dbReference type="KEGG" id="ovi:T265_00564"/>
    <dbReference type="CTD" id="20314752"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="71" mass="8130" checksum="A9B6F2636AE49BBC" modified="2014-10-01" version="1">MKRPGPAHSLAWRHHEREIQLGSRIDVVTYAQARAQRLVLSTEHAMDRRKTGLDARPQLQPKHGSSTKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A697</accession>
    <name>A0A075A697_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_09052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596871">
        <property type="protein sequence ID" value="KER22969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173285.1">
        <property type="nucleotide sequence ID" value="XM_009175021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A697"/>
    <dbReference type="GeneID" id="20323231"/>
    <dbReference type="KEGG" id="ovi:T265_09052"/>
    <dbReference type="CTD" id="20323231"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER22969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="92" mass="9968" checksum="E9E4F0FF74CA1934" modified="2014-10-01" version="1">MALSVHFCHLISHQTHWATGWLALRMPYVYHFPISILCVSSDDTRQNANSAGKLAPPYSAVAGPNPACRSRRATTVGQLPTSAVIAQTHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A6V4</accession>
    <name>A0A075A6V4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M16 middle/third domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">T265_02427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164924.1">
        <property type="nucleotide sequence ID" value="XM_009166660.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A6V4"/>
    <dbReference type="MEROPS" id="M16.005"/>
    <dbReference type="GeneID" id="20316615"/>
    <dbReference type="KEGG" id="ovi:T265_02427"/>
    <dbReference type="CTD" id="20316615"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="226"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="511"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KER31380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="149458" checksum="293170C3B3B51453" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7M1</accession>
    <name>A0A075A7M1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">T265_08636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596848">
        <property type="protein sequence ID" value="KER23469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172766.1">
        <property type="nucleotide sequence ID" value="XM_009174502.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A7M1"/>
    <dbReference type="GeneID" id="20322815"/>
    <dbReference type="KEGG" id="ovi:T265_08636"/>
    <dbReference type="CTD" id="20322815"/>
    <dbReference type="OrthoDB" id="29306at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="119"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1321"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KER23469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2062" mass="228256" checksum="4E661E933E2A14B0" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A7R3</accession>
    <name>A0A075A7R3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM3</name>
        <name evidence="11" type="ORF">T265_08600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596846">
        <property type="protein sequence ID" value="KER23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172719.1">
        <property type="nucleotide sequence ID" value="XM_009174455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A7R3"/>
    <dbReference type="STRING" id="6198.A0A075A7R3"/>
    <dbReference type="GeneID" id="20322779"/>
    <dbReference type="KEGG" id="ovi:T265_08600"/>
    <dbReference type="CTD" id="20322779"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="12108" checksum="A96F4EE653C9A9B6" modified="2014-10-01" version="1">MEKEEKDDALVEQPVLVEEPLDLIRLSLDERIYVKMRHNRELRGTLHAFDSHLNMILGNAEETVTTLEIDEETFEEVYKTTKRTIPMLFIRGDGVILVSPPQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A961</accession>
    <name>A0A075A961_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164017.1">
        <property type="nucleotide sequence ID" value="XM_009165753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A961"/>
    <dbReference type="STRING" id="6198.A0A075A961"/>
    <dbReference type="GeneID" id="20315875"/>
    <dbReference type="KEGG" id="ovi:T265_01687"/>
    <dbReference type="CTD" id="20315875"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="402" mass="44678" checksum="44F0792D3EC32B1F" modified="2014-10-01" version="1">MAGHKDGPIVETGKPSFVIDLTLGAGCRSSERLQDTAKKDSPKLISGAHPMAVPGFEPLTSSMRGECVTTATPRHVGRSFIFTSEQADVFTLERCDWCARRSNDEMSSLFGLKSAMMNRNSHHEDAPDARQNKAKESDDKLPSIFDERNGRLRRLSVAQGVRKLTLASGACSISSRLYTSSKARWPKLGRRGSIPALVLPSGCTAVKHPNGATAERFFYYLFIVMDINDISRDSIQRAFGTKRIMPSPGHDFSQTEHSASRATPSQDTGRLLTFRGSVTTPVSRRASQQTPSSSSLGLSLMSIFAAKKMSRRFLAALSEHEGRDRRSGSFRKIFGTIFEIPQYIFIEETVHMVAENSSSAHDRYCPSWGSSGRHSRRVSVNLMFYLNPNWTVFEKYTHLQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9N5</accession>
    <name>A0A075A9N5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase, family 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_01520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163825.1">
        <property type="nucleotide sequence ID" value="XM_009165561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9N5"/>
    <dbReference type="STRING" id="6198.A0A075A9N5"/>
    <dbReference type="GeneID" id="20315708"/>
    <dbReference type="KEGG" id="ovi:T265_01520"/>
    <dbReference type="CTD" id="20315708"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46624" checksum="E070E75CA1B3A621" modified="2014-10-01" version="1">MYVASSRIRLPRGQSAHFSRRLAVSFGAFLLTVALLALTLKWYLPSPLDIIKTPVFPKIDRNPKPYTIHLVHVIKGEATLARSITLLKSVFYYRGILRSNSPECYLRRIPSPHLCAKQRVIEQASIHLHLIVEQKLLSATHSCVNQWRVAQFNWSVYDLDLYLPRVSWIRNRHGSGVGALSKMLVPDILPTSVTKAIVLDTDTLLNADILELWKLFDNFTQIQIFGMAWETDPLGPENAEIPIPKNGVNSGVVLMHLSRMRRAKWSQLFEWAVREVLFQYGVLSIGEQSALNVLIQNRPELYYPIPCEWNLQLWSEAVLFSCPVIWTDRLSEEAICSEYESPKHGDLAHPGIPNLVHSNFSPGKPESGGNAPSSFRASLNASKAQTMDELRLRFLEVYWSFQPIPQSCFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9N9</accession>
    <name>A0A075A9N9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_12809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596634">
        <property type="protein sequence ID" value="KER32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163851.1">
        <property type="nucleotide sequence ID" value="XM_009165587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075A9N9"/>
    <dbReference type="STRING" id="6198.A0A075A9N9"/>
    <dbReference type="GeneID" id="20326977"/>
    <dbReference type="KEGG" id="ovi:T265_12809"/>
    <dbReference type="CTD" id="20326977"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="89" mass="10295" checksum="439F67BD3A184045" modified="2014-10-01" version="1">MGEHKAVIKNADMSEEMQQDAVECATQALEKFNIEKDIAAYIKKEFDKKYNPTWHCVVGRNFGSYVTHETKHFIYFYIGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075A9W7</accession>
    <name>A0A075A9W7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171919.1">
        <property type="nucleotide sequence ID" value="XM_009173655.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075A9W7"/>
    <dbReference type="GeneID" id="20322157"/>
    <dbReference type="KEGG" id="ovi:T265_07978"/>
    <dbReference type="CTD" id="20322157"/>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <source>
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    <sequence length="1918" mass="200948" checksum="B1F8CE4C484A0073" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAE4</accession>
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        <recommendedName>
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        </recommendedName>
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                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="442" mass="48820" checksum="44D5C4BBB54826B5" modified="2014-10-01" version="1">MAVNINREVEDTFYRYKMPKLNAKVEGKGNGIKTVIVNVSDIAKALNRKPIYLTKFFGCELGAQIHVDDKNERYIVNGAHEATKLQELLDGFIKKFVLCQGCGNPETTMHVNRKTGTVGTTCKACGSQGQLDVAHRLTQYIVKNPPEPDTSSNKAKPKKGKKGKNGERTSDDHEVSTAGDENSGYSPTATALEGDDDDWGEDTTEEAQLQRMSELSAMAQSLALSVDVDKSESEKADVFYKHLLQLQRKNAVLTHRRDIRQQADSLELGPRAVLVLAEALLSSPTAIIGDIKKFAPVFLLFTRVGGNEKRAQQYVLGAMAKLIERHTEHNLLSKACHILKALYDNDIIEEDVIIAWYEKGPSKKFVSRELSSKILSHCAPMVKWLQEAEEESEDSEADDEVPDARSNGTSEATVDVEPKESPPATESKDGTESEDEIDIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAV0</accession>
    <name>A0A075AAV0_OPIVI</name>
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        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="EMBL" id="KL596801">
        <property type="protein sequence ID" value="KER24669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171577.1">
        <property type="nucleotide sequence ID" value="XM_009173313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AAV0"/>
    <dbReference type="STRING" id="6198.A0A075AAV0"/>
    <dbReference type="GeneID" id="20321896"/>
    <dbReference type="KEGG" id="ovi:T265_07717"/>
    <dbReference type="CTD" id="20321896"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="46"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER24669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="369" mass="41393" checksum="BD87C1D32E6D8305" modified="2014-10-01" version="1">MPRKFLSTVVPSATFNLEEYKSFKLDSLPPAQTLCSREDALAYLETLQRIRRMETACSNMYKEKKIRGFCHLYSGQEAVVVGIEAALKPGDTIITAYRCHGFTHTRGVSVKSIFAELLGRKTGCSAGVGGSMHLYHKDFYGGNGIVGAQVPLGVGIGLRMKYRGDPNISVTLYGDGAANQGQVFEAYNMAKLWNLPVVFICENNKYGMGTAANRASANTAYYTRGDYIPGLWVDGMDVLTVREAMRFARDWCMSGKGPLLLETETYRYHGHSMSDPGTSYRTREEVQSVRSGRDPILLFQKRCIEANLFTQDEAKNLEKRVRQEVEKDAEDCMNDPEPDLDDRFLHVYSKAPPQFEVRGCDPLTYFKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AAZ7</accession>
    <name>A0A075AAZ7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">T265_07639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KL596798">
        <property type="protein sequence ID" value="KER24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171476.1">
        <property type="nucleotide sequence ID" value="XM_009173212.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A075AAZ7"/>
    <dbReference type="GeneID" id="20321818"/>
    <dbReference type="KEGG" id="ovi:T265_07639"/>
    <dbReference type="CTD" id="20321818"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052489">
        <property type="entry name" value="LRWD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056160">
        <property type="entry name" value="WD_LRWD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24370:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24370">
        <property type="entry name" value="OPTICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23215">
        <property type="entry name" value="WD_LRWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1187"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="1640"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1671"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1891"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="956"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KER24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2049" mass="228047" checksum="65842D38FD24765B" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AB96</accession>
    <name>A0A075AB96_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596628">
        <property type="protein sequence ID" value="KER33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163169.1">
        <property type="nucleotide sequence ID" value="XM_009164905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AB96"/>
    <dbReference type="GeneID" id="20315178"/>
    <dbReference type="KEGG" id="ovi:T265_00990"/>
    <dbReference type="CTD" id="20315178"/>
    <dbReference type="OrthoDB" id="5986101at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="156" mass="17558" checksum="39B6E828EA7143A9" modified="2014-10-01" version="1">MKAGSKILRHPPIDQEGAVTSNYHVTPPKNPRMTPTSYPHLPEPLNLRMGMPQRKVPEFDDNPLNYWKFLRGFVGGVAQYVTNPADRLDFLSMHANVKQERPSITVQYSSRNTATQKPGRYWVAGSVTPRLLQDNTLRLSQPGNPSGRTTPARYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ADH7</accession>
    <name>A0A075ADH7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">T265_06601</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="KL596757">
        <property type="protein sequence ID" value="KER26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170169.1">
        <property type="nucleotide sequence ID" value="XM_009171905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ADH7"/>
    <dbReference type="STRING" id="6198.A0A075ADH7"/>
    <dbReference type="GeneID" id="20320780"/>
    <dbReference type="KEGG" id="ovi:T265_06601"/>
    <dbReference type="CTD" id="20320780"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13 14">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="275"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="365"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="388"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="412"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KER26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="515" mass="55581" checksum="1D92CE00B6B107C6" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AEY0</accession>
    <name>A0A075AEY0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">T265_05714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596729">
        <property type="protein sequence ID" value="KER27179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169051.1">
        <property type="nucleotide sequence ID" value="XM_009170787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AEY0"/>
    <dbReference type="STRING" id="6198.A0A075AEY0"/>
    <dbReference type="GeneID" id="20319896"/>
    <dbReference type="KEGG" id="ovi:T265_05714"/>
    <dbReference type="CTD" id="20319896"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KER27179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="18723" checksum="37B9E5C3C1BEE99E" modified="2014-10-01" version="1">MGSIGGGVIHSYKGYRNAPSGYIRKLASALSNARQRAPLLGGAFAIWGGMFTAVDCTLVFARQKEDPWNSITSGAITGAVLAVRHGPAAMVGQAVIGGVILAIIEGLGIMMNRFAPMLMQPPPEEHPDSAGSKDGGQGGPGGTGGGFGVFNLFGSTSSNSSDTTTGSPGSAGGGGSGATTTKSGFVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AFB4</accession>
    <name>A0A075AFB4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168707.1">
        <property type="nucleotide sequence ID" value="XM_009170443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AFB4"/>
    <dbReference type="STRING" id="6198.A0A075AFB4"/>
    <dbReference type="GeneID" id="20319618"/>
    <dbReference type="KEGG" id="ovi:T265_05436"/>
    <dbReference type="CTD" id="20319618"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF41">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="437"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="694" mass="76617" checksum="E16DAB9DA8A602A5" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AGQ4</accession>
    <name>A0A075AGQ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596688">
        <property type="protein sequence ID" value="KER28954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167306.1">
        <property type="nucleotide sequence ID" value="XM_009169042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AGQ4"/>
    <dbReference type="STRING" id="6198.A0A075AGQ4"/>
    <dbReference type="GeneID" id="20318515"/>
    <dbReference type="KEGG" id="ovi:T265_04333"/>
    <dbReference type="CTD" id="20318515"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="153" mass="17566" checksum="D66493A3ADBDDC41" modified="2014-10-01" version="1" fragment="single">GFQTFTQTPVLQRPISPQRTDFQILSQTNSGKLLDPRLDAVARQFLSGKDVPETAVYELASKPTVSEELCSEHLSSSATFNHSPKAQRREPSSSAIPMFRKPREDDDKYRRRVALGGIARWFRSYFSVHNRSLTFRERRFFLLLAIFFIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AH62</accession>
    <name>A0A075AH62_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596679">
        <property type="protein sequence ID" value="KER29394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166834.1">
        <property type="nucleotide sequence ID" value="XM_009168570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AH62"/>
    <dbReference type="GeneID" id="20318149"/>
    <dbReference type="KEGG" id="ovi:T265_03963"/>
    <dbReference type="CTD" id="20318149"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER29394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="103" mass="11724" checksum="10DAB6097D7A1EC1" modified="2014-10-01" version="1">MPPEGCTRVEIVPGYPSLDRGSREAEIGFEQRTFRLTQSPSSRQPYMLLETKLQEISEIHLFANKFGLAGDSVRDSAAFQRIAIDYDDDVLRGLELPLRKLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHQ2</accession>
    <name>A0A075AHQ2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_03232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596663">
        <property type="protein sequence ID" value="KER30279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165929.1">
        <property type="nucleotide sequence ID" value="XM_009167665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHQ2"/>
    <dbReference type="GeneID" id="20317419"/>
    <dbReference type="KEGG" id="ovi:T265_03232"/>
    <dbReference type="CTD" id="20317419"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER30279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="150" mass="16973" checksum="C5B4314CD31303D1" modified="2014-10-01" version="1">MYDARHEHTNEYTQKLVGERGNLFLKRNLMVGLELKLKHRLAAKSVVSTEFLSRLRKKGQQTHEEAVSYKAVCRGPTERKNCIVPSDADPESIGRVPSAVAYEDCIFNTSSSNAHQLIHNLQLDDQQIGITFRMIMEAEKCNCVPQSAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AHS1</accession>
    <name>A0A075AHS1_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Papain family cysteine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_03208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165891.1">
        <property type="nucleotide sequence ID" value="XM_009167627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AHS1"/>
    <dbReference type="STRING" id="6198.A0A075AHS1"/>
    <dbReference type="MEROPS" id="C01.152"/>
    <dbReference type="GeneID" id="20317395"/>
    <dbReference type="KEGG" id="ovi:T265_03208"/>
    <dbReference type="CTD" id="20317395"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49412" checksum="42D56C9CDDE79BC5" modified="2014-10-01" version="1">MYMYRDISNIVATEKRSGLVQRIQLPENIINERFIWVPGESLEKTKLREQEDFFENPAFCNVMGIILLAAILTFLPYKAYGKSITSDLAQLTLVQNFTKWEAAGHLSLLDAYYLYNIFGDRWDVALNGAWKHFVKKYKREYAGPVEQARRFRIFTRNFIRVNQHNVRYIQGDTFYTMGINRFSDRTTEEFRRLLGFRDLRNTSRVNSKYITIATEPPPSIDWRTTGAVTPVKDQGQCGSCWAFSATGAIEGQHFMATKQLVSLSEQQLVDCSSHFGNFGCSGGWMDNAFKYVKHTHGITTETNYPYISGETGAPNPHCKFHGKTVATTVTGIVDLPRGNESALKQAVGLHGPISVAIHASLESFVGYKSGVYSDEQCSSDELDHAVLVVGYGEENGIPYWLIKNSWGVDWGELGYVKIRRNHHNLCGVASRASYPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AI75</accession>
    <name>A0A075AI75_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_13050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596650">
        <property type="protein sequence ID" value="KER31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165158.1">
        <property type="nucleotide sequence ID" value="XM_009166894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AI75"/>
    <dbReference type="STRING" id="6198.A0A075AI75"/>
    <dbReference type="GeneID" id="20327218"/>
    <dbReference type="KEGG" id="ovi:T265_13050"/>
    <dbReference type="CTD" id="20327218"/>
    <dbReference type="OrthoDB" id="6242193at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="507" mass="57366" checksum="C2B7740EB735071F" modified="2014-10-01" version="1">MPQQTISRHFTTLSGFYYSGLRAQTSLGMPKILNERVGRPRTAEDEMSGLPGLESKRIDVVATFETAEASWPHGACRIRTNLWQLLITGRSGSPMLILITPLSVAAFLALFGSIIIIIIISYLFRRNDNAFAFQHASTVIELSTPSVSTRFRLRASSNPEAYVAACAAIGIVLRRKYPYLTGYLLIVASVRFVWPVETRLLASLILRRLMASREVLTRENQAGFRPDRGFVDHIFTLRQVLEQRHMYRRPTILVFLDFKDRFYDTLNVLLRRAKSPVIVVVAGDMNAQVGRLSASETQLGGRHGLDLELTDNGERLLQLCVDRRLFLCSTNFRNSRNRLATWCPPTAGRPQAQIDHIAFSYQWSGLITHCRSFWNTFVGAHHALVRSHFSLLTGIIFNNLNPYLDEIATALHSAGNFACGTTHPGALKHWISDRTVALLKSRRNIPAGPEHNPMRRVVRRQVKVSLRSDREVWWTQKAKEMEEAQKAGNARILFQLIRATGPRKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075AIU0</accession>
    <name>A0A075AIU0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_01653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596636">
        <property type="protein sequence ID" value="KER32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009163983.1">
        <property type="nucleotide sequence ID" value="XM_009165719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075AIU0"/>
    <dbReference type="STRING" id="6198.A0A075AIU0"/>
    <dbReference type="GeneID" id="20315841"/>
    <dbReference type="KEGG" id="ovi:T265_01653"/>
    <dbReference type="CTD" id="20315841"/>
    <dbReference type="OrthoDB" id="6242432at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="418" mass="45016" checksum="9ECC164741A51A65" modified="2014-10-01" version="1">MSLHFLVNGRLPDAVQTGLTTSVSPDGIACLSTELNSLQIQDSGILSGPSSGLSITNNSPTGHSSDPRSDVLAPVAVSDASCEKLNQLSWWPANKHINPPPNKLIVGVPPSSASYSLQPVPPVIRPMLPSADFTIPFSIPSPSREEMVGWSPVNHFFQYAPQSPYTWLDGAVRFPYVATANMTVPPALPFVSQPMYFVPLMNQVPLNQPIVPIPPPPPPPLVQSWISGFPNSMTPPEEHSVTIPACPPRTSLHLGTPGLATPTSFANTSSASRRLATNGEPNYGRRSGVDQLHSRSEVNKGKTNTGSLNSKSTGKKKLGFHNNILYKTELCHDFLVSQACPRGLACQYAHGETELRDPRNHPLYKTTVCQDFRLTGTCVRGAKCLHLHPPETITKRPQRPNSPCLARSTPKSGTAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YTX4</accession>
    <name>A0A074YTX4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_16197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL605405">
        <property type="protein sequence ID" value="KER18241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178012.1">
        <property type="nucleotide sequence ID" value="XM_009179748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YTX4"/>
    <dbReference type="STRING" id="6198.A0A074YTX4"/>
    <dbReference type="GeneID" id="20330362"/>
    <dbReference type="KEGG" id="ovi:T265_16197"/>
    <dbReference type="CTD" id="20330362"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER18241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9125" checksum="BB41F33B55B31397" modified="2014-10-01" version="1" fragment="single">MGAYCYAELGTMMPRSGADYSYVYEAFGPFFGFLRLWIEVIVARPVSAAIISMVFANYLLRPAFPTCTESPPAAVRLLACVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YVV2</accession>
    <name>A0A074YVV2_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_12151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597900">
        <property type="protein sequence ID" value="KER18803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177454.1">
        <property type="nucleotide sequence ID" value="XM_009179190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YVV2"/>
    <dbReference type="GeneID" id="20326319"/>
    <dbReference type="KEGG" id="ovi:T265_12151"/>
    <dbReference type="CTD" id="20326319"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER18803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="121" mass="13679" checksum="114E3787AD03C254" modified="2014-10-01" version="1">MCIADGAQHAEKQPEARALSDIAEMMLSGKLNMVQAMARLTSVVERMFPDVWTPHKVAVRKGVPKPQKARRRVIYARPRSLFKRKQKEAAVCSRWTVKGTLEICRGQAQRYDGILERSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YWB0</accession>
    <name>A0A074YWB0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_15677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597353">
        <property type="protein sequence ID" value="KER19061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177190.1">
        <property type="nucleotide sequence ID" value="XM_009178926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YWB0"/>
    <dbReference type="GeneID" id="20329842"/>
    <dbReference type="KEGG" id="ovi:T265_15677"/>
    <dbReference type="CTD" id="20329842"/>
    <dbReference type="OrthoDB" id="6298486at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704781" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13652" checksum="52A19E1B2964865F" modified="2014-10-01" version="1" fragment="single">MLWRASLTVFIISSVCDAIVNTYPFDAPYSDVKREQEHAVDHVSCRLTLRHKKPLGWQMGLFARCQLLKEDRGTVTMKVELFVHGLPQFLHKSPTDLLSWFVNWLFWVKMEPCNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YXM5</accession>
    <name>A0A074YXM5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_11809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597216">
        <property type="protein sequence ID" value="KER19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009176841.1">
        <property type="nucleotide sequence ID" value="XM_009178577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YXM5"/>
    <dbReference type="GeneID" id="20325977"/>
    <dbReference type="KEGG" id="ovi:T265_11809"/>
    <dbReference type="CTD" id="20325977"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER19418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10245" checksum="82F2EC9F4FA17D26" modified="2014-10-01" version="1">MAQDMSDAEVRGRLSHRIERDIDIMLQSLTAVCQRLIDLKYDTATMVQSPTTSNSSVYAINSNTPSVGKSPIEKRADPRVYGLAMSSISVIIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074YY19</accession>
    <name>A0A074YY19_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_16304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL612267">
        <property type="protein sequence ID" value="KER18082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009178171.1">
        <property type="nucleotide sequence ID" value="XM_009179907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074YY19"/>
    <dbReference type="GeneID" id="20330469"/>
    <dbReference type="KEGG" id="ovi:T265_16304"/>
    <dbReference type="CTD" id="20330469"/>
    <dbReference type="OrthoDB" id="6300667at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="73" mass="7893" checksum="7C944CD617AC7AF7" modified="2014-10-01" version="1" fragment="single">MYYPEEQSRPLANSIAHRLDENPAQALSRLETATIIAPSAGEQGVMGTLEDEMGAPISPYDIGEPDAHPSRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z1G7</accession>
    <name>A0A074Z1G7_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_10720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597018">
        <property type="protein sequence ID" value="KER20818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175442.1">
        <property type="nucleotide sequence ID" value="XM_009177178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z1G7"/>
    <dbReference type="STRING" id="6198.A0A074Z1G7"/>
    <dbReference type="GeneID" id="20324888"/>
    <dbReference type="KEGG" id="ovi:T265_10720"/>
    <dbReference type="CTD" id="20324888"/>
    <dbReference type="OrthoDB" id="1111004at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER20818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="132" mass="14188" checksum="14DFA596BB2D0332" modified="2014-10-01" version="1">MAMSTGLSCLMSSLFSIILFAGMRLIKEWLCSSKSLTILGGFLGSILFVLILTALNNAENLIFGKGFQAEIFPEVAVSIFIAALVAGFVHPVSGTTCIPFSLYALYRINQLSAEQYGAVKQSTVISGQKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z433</accession>
    <name>A0A074Z433_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_11149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL597073">
        <property type="protein sequence ID" value="KER20267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175995.1">
        <property type="nucleotide sequence ID" value="XM_009177731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z433"/>
    <dbReference type="GeneID" id="20325317"/>
    <dbReference type="KEGG" id="ovi:T265_11149"/>
    <dbReference type="CTD" id="20325317"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER20267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="116" mass="13271" checksum="D5986FE38EC58312" modified="2014-10-01" version="1">MNQFNGASHVTQLGAEPLGNYGVSLTDFQEYVWVPQQRSTRYLHPDSQQDLPTLICNTISPLPKIRNSNKLSTSFFELFPAHWRIPTAYDLWNFRVEKTTVRCSAAIQHRFASITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z473</accession>
    <name>A0A074Z473_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596934">
        <property type="protein sequence ID" value="KER21891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174372.1">
        <property type="nucleotide sequence ID" value="XM_009176108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z473"/>
    <dbReference type="STRING" id="6198.A0A074Z473"/>
    <dbReference type="GeneID" id="20324064"/>
    <dbReference type="KEGG" id="ovi:T265_09896"/>
    <dbReference type="CTD" id="20324064"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="143" mass="16559" checksum="07BA076C5BB0CCC8" modified="2014-10-01" version="1">MNFGAGQTGIDIHLHLDGAVRPRTLFELAQRRNIPIPYSTPEELERAILPTKPYTLANFLKGFYFLLPILAGDKAFLAFCSREFRETSFEQSKIDAHEQTDLFFTAFLPFFVALQRTHWRQVMVVEQFEKLSTDTPLSANIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z4C5</accession>
    <name>A0A074Z4C5_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lon proteolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_11070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL597063">
        <property type="protein sequence ID" value="KER20372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009175884.1">
        <property type="nucleotide sequence ID" value="XM_009177620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z4C5"/>
    <dbReference type="STRING" id="6198.A0A074Z4C5"/>
    <dbReference type="GeneID" id="20325238"/>
    <dbReference type="KEGG" id="ovi:T265_11070"/>
    <dbReference type="CTD" id="20325238"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="673"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER20372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="895" mass="100321" checksum="100609277FE8A550" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z7X7</accession>
    <name>A0A074Z7X7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_14691</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="EMBL" id="KL596861">
        <property type="protein sequence ID" value="KER23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173074.1">
        <property type="nucleotide sequence ID" value="XM_009174810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z7X7"/>
    <dbReference type="STRING" id="6198.A0A074Z7X7"/>
    <dbReference type="GeneID" id="20328857"/>
    <dbReference type="KEGG" id="ovi:T265_14691"/>
    <dbReference type="CTD" id="20328857"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="28603" checksum="9B5803945F5A9CE0" modified="2014-10-01" version="1">MAKSTFEYVRRFESFDHCLPHSWIVVRIDGQGFGKFTEKHGFQKPNDKRGLRLACRAAERVMQRHSDIILAYGQSDEFSFVFQRSTDKFNRRASKLSSTVVSLFASSYVFEWTNFFPDVKLLYPPAFDSRVVLYPTNRTLRDYLSWRQADCHINNLYNTCFWKLVQEGSLTTTEAEERLRGTLSSDKNEILFSEFGCNYNNEPELFRKGTTLYRNKDAKGAVEQANIDIIKDAFWQAHPELLEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z826</accession>
    <name>A0A074Z826_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">T265_14654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172896.1">
        <property type="nucleotide sequence ID" value="XM_009174632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z826"/>
    <dbReference type="STRING" id="6198.A0A074Z826"/>
    <dbReference type="GeneID" id="20328820"/>
    <dbReference type="KEGG" id="ovi:T265_14654"/>
    <dbReference type="CTD" id="20328820"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KER23361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="203" mass="23295" checksum="1D2059549A18C12A" modified="2014-10-01" version="1">MVRYSWEPKDEDESRTCKARVPYLRAHFKNTHECARAIKGMTLQRAQTFLKNVIEKKEIVPFRRFNGGVGRHAQAKAWGTTQGRWPKKSAQMLLQLLHNAFSNGVNKDIKGGEASRLYIKHIQVSYFTITSNLVNQAPAMRRRTYRAHGRINPYMCSPCHVEVILATKDDLVPKVSANAPQPLKKKESKKKMKRQLMKESAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z888</accession>
    <name>A0A074Z888_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_09979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596942">
        <property type="protein sequence ID" value="KER21772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174480.1">
        <property type="nucleotide sequence ID" value="XM_009176216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z888"/>
    <dbReference type="GeneID" id="20324147"/>
    <dbReference type="KEGG" id="ovi:T265_09979"/>
    <dbReference type="CTD" id="20324147"/>
    <dbReference type="OrthoDB" id="10063766at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER21772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="237" mass="26115" checksum="DE560BA175BD68D9" modified="2014-10-01" version="1">MDIQTPYEAHVRPLLEYANQVVYSGCTDDDTLIESVQRAAARTVASHKSVDYVTRLAMLDLFSLEYICLGGDNNSGFAEAKIGFSHTSLPGAQVAEFEEDNCSNANPPSEPCILEKDDGRYQCVVCAMELIPRFYADYLNCRFVPPMIITLNMIMAVFHRVLIHIPSDIPTVRYAVLLGGMPFAEEPFARVMLDDTGKADGLSSATPSSKSSLEPVKPHCGIAPVDAGRHRKSRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8B8</accession>
    <name>A0A074Z8B8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_14653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596852">
        <property type="protein sequence ID" value="KER23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172895.1">
        <property type="nucleotide sequence ID" value="XM_009174631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8B8"/>
    <dbReference type="STRING" id="6198.A0A074Z8B8"/>
    <dbReference type="GeneID" id="20328819"/>
    <dbReference type="KEGG" id="ovi:T265_14653"/>
    <dbReference type="CTD" id="20328819"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="220" mass="24378" checksum="E4DA9A7498B20C89" modified="2014-10-01" version="1" fragment="single">HSLLYVPFIRLVIDFQQVVLESAAKGTDQNVGVGYVSLSIVYAAFAIFNWFSPVAVLLLGEKYTMFLGSICYFLFVACFMEPRAWSLYLGSVVCGFGAAVLWTAQGAFITRWSDSRNINKHFSIFWALLQLSQIVGGLYVYLSLADVTYIDRRLRLQLFGGMLGCGAVGTLLFLGLRPPPAISQPEDLSVLSVPNSEDGNDVRVSRPKMVFDSTLKTFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z8V4</accession>
    <name>A0A074Z8V4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Katanin p80 WD40 repeat-containing subunit B1</fullName>
            <shortName evidence="7">Katanin p80 subunit B1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">p80 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KATNB1</name>
        <name evidence="11" type="ORF">T265_09809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Microtubule organizing center</location>
            <location evidence="7">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Spindle</location>
        </subcellularLocation>
        <text evidence="7">Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat KATNB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596925">
        <property type="protein sequence ID" value="KER22017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174250.1">
        <property type="nucleotide sequence ID" value="XM_009175986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z8V4"/>
    <dbReference type="STRING" id="6198.A0A074Z8V4"/>
    <dbReference type="GeneID" id="20323977"/>
    <dbReference type="KEGG" id="ovi:T265_09809"/>
    <dbReference type="CTD" id="20323977"/>
    <dbReference type="OrthoDB" id="10251605at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000462">
        <property type="entry name" value="Katanin p80 WD40 repeat-containing subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03022">
        <property type="entry name" value="Katanin_p80_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026962">
        <property type="entry name" value="KTNB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="10">
        <location>
            <begin position="632"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER22017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="793" mass="86125" checksum="07C7B9357E2C9771" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9A0</accession>
    <name>A0A074Z9A0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_08511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172596.1">
        <property type="nucleotide sequence ID" value="XM_009174332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9A0"/>
    <dbReference type="STRING" id="6198.A0A074Z9A0"/>
    <dbReference type="GeneID" id="20322690"/>
    <dbReference type="KEGG" id="ovi:T265_08511"/>
    <dbReference type="CTD" id="20322690"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER23658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="172" mass="19767" checksum="F4522D7133740663" modified="2014-10-01" version="1">MEPFLEAFFSIDTDHSERITIRELQDYVKRNNIDQSMVKRWQVLFDANDSGVITLDEFCKTLGIRPSEARAYNANMVRASHGPSLPREVDVITATLPFDQQVDIVNEVMRLTRNEPFDENLNVKILPTSVPNIWATLKNERRDNLGHMCLSAVAVCWKSCLVLDSLETYTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074Z9F1</accession>
    <name>A0A074Z9F1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_14578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596838">
        <property type="protein sequence ID" value="KER23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172534.1">
        <property type="nucleotide sequence ID" value="XM_009174270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074Z9F1"/>
    <dbReference type="GeneID" id="20328744"/>
    <dbReference type="KEGG" id="ovi:T265_14578"/>
    <dbReference type="CTD" id="20328744"/>
    <dbReference type="OrthoDB" id="10036512at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="147" mass="17228" checksum="5A81DBD6764B6EF9" modified="2014-10-01" version="1" fragment="single">TIPIEQNIGFLWVKHNPDTIEQQNAILSAYFPRKCRGLVDLDWWKASELRHFLLYKIFTSQRLQMPHTVYLFSQQYSDFLIDVYKVAVPKVAASFGSNHLVYNIQLFSHLVSFVKLYGCFIRFSCFLYKSELGHLNPYTHVPKPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZA92</accession>
    <name>A0A074ZA92_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_08104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596820">
        <property type="protein sequence ID" value="KER24166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172075.1">
        <property type="nucleotide sequence ID" value="XM_009173811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZA92"/>
    <dbReference type="GeneID" id="20322283"/>
    <dbReference type="KEGG" id="ovi:T265_08104"/>
    <dbReference type="CTD" id="20322283"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="469"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER24166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="752" mass="86172" checksum="AED9D86294966D52" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZAH2</accession>
    <name>A0A074ZAH2_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL52</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L52, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">T265_08020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596816">
        <property type="protein sequence ID" value="KER24281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171971.1">
        <property type="nucleotide sequence ID" value="XM_009173707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZAH2"/>
    <dbReference type="STRING" id="6198.A0A074ZAH2"/>
    <dbReference type="GeneID" id="20322199"/>
    <dbReference type="KEGG" id="ovi:T265_08020"/>
    <dbReference type="CTD" id="20322199"/>
    <dbReference type="OrthoDB" id="10249237at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034596">
        <property type="entry name" value="Ribosomal_mL52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34090">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L52, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34090:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18699">
        <property type="entry name" value="MRPL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KER24281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27983" checksum="A714F2B4B6053BC6" modified="2014-10-01" version="1">MPHITSLNLALARSFHCSRILPSGGMFRARRRLPPSNNEWGPLTDRPDFSVIGKPDPRFTSEGQRRRAIKNYQFANDAIRLVSEIYETKAKSEAMKRDRDSFIQQAEKLEAEIVDPTQLTSASRLSLSRLGQPGSIPTLVLSLGDMAVKHRKRSTAERLFSFPFSTWQVGDSSLRRTALWRVEGFGVTYRLGVIYLLRERSEPRIAILSAYPVCERTSREHFAPRSFIGSQRNFRQQVNNEVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZB78</accession>
    <name>A0A074ZB78_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596806">
        <property type="protein sequence ID" value="KER24551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171721.1">
        <property type="nucleotide sequence ID" value="XM_009173457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZB78"/>
    <dbReference type="GeneID" id="20328566"/>
    <dbReference type="KEGG" id="ovi:T265_14400"/>
    <dbReference type="CTD" id="20328566"/>
    <dbReference type="OrthoDB" id="6245166at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="456" mass="50829" checksum="90FABC05F7E02E9D" modified="2014-10-01" version="1" fragment="single">MSQSITTPNTTINRTGKLQSVEELDAIINMLAVSRNSPFDLDCSNLLKSEDVDEPNDSHSNALSQLLRDYCEKMEGSSYPDPSSTVHQSYQQTTIECSDSQLEKLQQLKERLTLSSEKFSSILDSSEPGTQPMVPRDRLPENKPIPFPDPTPLCQAVENLERLFSVHKRIATGLERIVQVNADRIRPVVCFTPKKSRSAVAPFRCLTTMPPEGSTRTGILPVCLNLDRESREAEVGFEPRTFRSAIWFGFGQTTTGSHKQEAGPNVLKRIHTTNVEFETASIKNLSGNSDAFWMQHWKPAFGQCWVMIGCWVQTFDQPDLVLMPDRQSSRIHSQSCLGWTSRLMWNSECAKLICPSYVRACFACRDLRQSHSTAITKRKVRGSNPASASRRPLSRLGQPDSIPALALPSGGVAARHRKGVTAGQYFTFICNLEKQVLRHAVCVDLNARPAEHPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZBI0</accession>
    <name>A0A074ZBI0_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_14751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596872">
        <property type="protein sequence ID" value="KER22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173326.1">
        <property type="nucleotide sequence ID" value="XM_009175062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZBI0"/>
    <dbReference type="STRING" id="6198.A0A074ZBI0"/>
    <dbReference type="GeneID" id="20328917"/>
    <dbReference type="KEGG" id="ovi:T265_14751"/>
    <dbReference type="CTD" id="20328917"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="261" mass="28496" checksum="BC2B02CBA10651E8" modified="2014-10-01" version="1">MWSSTAYGGMLVNADYGGGYMASAAGASISKKASNQGSTIPCTCAEILAATQEGDRFISPLGLEFSQVTLLGVVRSVNESATRIEYEIDDYTGPFVPVKMFVEDQDSLPAGQQSRPFRELSYVRVHGHVRNFQGAKQIIAFRVLPVTDMNELTTHIMEVIYTRMLNTKAKLDEASGVNLSKVNSSATNFGGNVANGLTALQNQILTIVRAFVGERGIPVTQLSEKLRGIPERQIRENLDFLSGEGYVYSTVDDDHFRATEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZCE4</accession>
    <name>A0A074ZCE4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596795">
        <property type="protein sequence ID" value="KER24833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171386.1">
        <property type="nucleotide sequence ID" value="XM_009173122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZCE4"/>
    <dbReference type="GeneID" id="20321744"/>
    <dbReference type="KEGG" id="ovi:T265_07565"/>
    <dbReference type="CTD" id="20321744"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="84" mass="9074" checksum="B1FA0AE386528F8A" modified="2014-10-01" version="1">MAMAYIGQHSCINLSRTEATPHQCPAGHPNGEYIYLPLPVVDTKVFIAMHHLQIRTASGASGTAELKTMQASTVVKMNCSDFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZD45</accession>
    <name>A0A074ZD45_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM32A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_07286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596784">
        <property type="protein sequence ID" value="KER25181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171037.1">
        <property type="nucleotide sequence ID" value="XM_009172773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZD45"/>
    <dbReference type="STRING" id="6198.A0A074ZD45"/>
    <dbReference type="GeneID" id="20321465"/>
    <dbReference type="KEGG" id="ovi:T265_07286"/>
    <dbReference type="CTD" id="20321465"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER25181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12730" checksum="5F72F74DED914F96" modified="2014-10-01" version="1">MSEYDKVVAGSLRIKSGQGIKKKKVAAEFPEATTVADEPEGSEPNTQKPKLSERSHLTKAQKELERRKDKRMLETVLSKAVKSHKQRIIEFNNHLETLTEHFDIQKVSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZE37</accession>
    <name>A0A074ZE37_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_10226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596966">
        <property type="protein sequence ID" value="KER21465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009174799.1">
        <property type="nucleotide sequence ID" value="XM_009176535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZE37"/>
    <dbReference type="GeneID" id="20324394"/>
    <dbReference type="KEGG" id="ovi:T265_10226"/>
    <dbReference type="CTD" id="20324394"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER21465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114948" checksum="B9B6FCA1CC20DDCE" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZEG7</accession>
    <name>A0A074ZEG7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 H</fullName>
            <ecNumber evidence="8">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">T265_08189</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="8"/>
    <dbReference type="EMBL" id="KL596824">
        <property type="protein sequence ID" value="KER24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172182.1">
        <property type="nucleotide sequence ID" value="XM_009173918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZEG7"/>
    <dbReference type="STRING" id="6198.A0A074ZEG7"/>
    <dbReference type="GeneID" id="20322368"/>
    <dbReference type="KEGG" id="ovi:T265_08189"/>
    <dbReference type="CTD" id="20322368"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KER24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="162" mass="18312" checksum="21EFA27A1BF975C1" modified="2014-10-01" version="1">MESNYEVTVLGAANELMVKFFGPAETPYEGGIWKVRVDLPERYPFKSPSIALFTNFLSSGTVCLDVINQQWSALYDLTNIFESFLPQLLAYPNPTDPLNSDAASLFMFKPSEYVMKVKEYVQRFATEEVLKAEENGGAEHNSSEEESSMSDYSDDETKDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFD1</accession>
    <name>A0A074ZFD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_07981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596814">
        <property type="protein sequence ID" value="KER24342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171922.1">
        <property type="nucleotide sequence ID" value="XM_009173658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFD1"/>
    <dbReference type="GeneID" id="20322160"/>
    <dbReference type="KEGG" id="ovi:T265_07981"/>
    <dbReference type="CTD" id="20322160"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER24342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="104" mass="11461" checksum="7AFA98024FB45E56" modified="2014-10-01" version="1">MIQTNARLVYSCQPLADSTGTPVSEVLIDWEQPIFSMQRQKSVVRTRLALPVDFSCLGLGNPAVSQPPSCGMVAENLSTAHDRFHPSWGSSGWRSRQVSVNLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZFF9</accession>
    <name>A0A074ZFF9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_07931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596812">
        <property type="protein sequence ID" value="KER24372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171860.1">
        <property type="nucleotide sequence ID" value="XM_009173596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZFF9"/>
    <dbReference type="STRING" id="6198.A0A074ZFF9"/>
    <dbReference type="GeneID" id="20322110"/>
    <dbReference type="KEGG" id="ovi:T265_07931"/>
    <dbReference type="CTD" id="20322110"/>
    <dbReference type="OrthoDB" id="6272054at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="122"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER24372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="375" mass="43224" checksum="48ED1BE7B2C04E52" modified="2014-10-01" version="1">MKFVRPRQYGICIFGPAVLSVPTVDPGIPAPDLRWMWRPRICQNLSEAREVVDGDERISVGKNRKRLVIRSAQLQHEGVYTCLASNGLGESLSPFVDIVILGNLHVCHFGHILRPVKITERPKILKTYDLSSRPSSPIKLRCVARGRPQVRIRWLQNGRPVVSENTLPRHNNAGQLQVFQVRLKHEAAWCSTFSCLRTSQTKESAEFQEGPNHIVLWQTRCVYFEDREFYWETHSELTFLQPVLREHEGIYACQASSSNDTFVNETTELQLLYPPQLIYSQPLKFSIRRKHDYSLPSAEYVTDLLNDHAINSQGQSFQGVRESALPDIKQNLSCYLRSNPLPWRVFWERVTDSTNSLCSNKRPPVTEQHKFLVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZG51</accession>
    <name>A0A074ZG51_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat and coiled-coil domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">T265_14367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596802">
        <property type="protein sequence ID" value="KER24632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171616.1">
        <property type="nucleotide sequence ID" value="XM_009173352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZG51"/>
    <dbReference type="STRING" id="6198.A0A074ZG51"/>
    <dbReference type="GeneID" id="20328533"/>
    <dbReference type="KEGG" id="ovi:T265_14367"/>
    <dbReference type="CTD" id="20328533"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000148">
        <property type="entry name" value="Leucine rich repeat and coiled-coil centrosomal protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF34">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="957"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="518"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="959"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KER24632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="990" mass="112730" checksum="FD6C4D8EFFEB1752" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZGV1</accession>
    <name>A0A074ZGV1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596748">
        <property type="protein sequence ID" value="KER26428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169839.1">
        <property type="nucleotide sequence ID" value="XM_009171575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZGV1"/>
    <dbReference type="GeneID" id="20320524"/>
    <dbReference type="KEGG" id="ovi:T265_06342"/>
    <dbReference type="CTD" id="20320524"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="142" mass="16188" checksum="59F5D8B9D6356127" modified="2014-10-01" version="1">MKFVSPVDTRDEPTYHVSTLRDISNSVPTETRRGLVHHVQLLKNIINERFNWVPAVAPFRCLAAMPHEGGTRARILPGSPSLDRGSREAEVEFEPRTFRNKLPESKKIKLIRRCEIEHNSLNLPACSKACGREKVGEFITVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZH90</accession>
    <name>A0A074ZH90_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596788">
        <property type="protein sequence ID" value="KER25062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171174.1">
        <property type="nucleotide sequence ID" value="XM_009172910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZH90"/>
    <dbReference type="GeneID" id="20321579"/>
    <dbReference type="KEGG" id="ovi:T265_07400"/>
    <dbReference type="CTD" id="20321579"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER25062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="94" mass="10675" checksum="76CD16A3D0C6B28D" modified="2014-10-01" version="1">MGTEIVAQLEYRRTIRRKSHIESFSCSTLPVPSCHATRRRHDGLDTARSPKPRQGQSRGRGRVRTMNLPLERYVCINSRVTTEKNRPAVAPFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIB5</accession>
    <name>A0A074ZIB5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596867">
        <property type="protein sequence ID" value="KER23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173211.1">
        <property type="nucleotide sequence ID" value="XM_009174947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIB5"/>
    <dbReference type="GeneID" id="20323176"/>
    <dbReference type="KEGG" id="ovi:T265_08997"/>
    <dbReference type="CTD" id="20323176"/>
    <dbReference type="OrthoDB" id="10486686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="136" mass="15434" checksum="E3C581C6F8A34E0C" modified="2014-10-01" version="1">MFFAELSFRSTTLVLLKSRFSAINQTGVIYYYEICKMMCIRDMWSKLAIGLSNRHFLQRLHPSTDGVTGTRSWKAHNTKNTQTLRDLFHAFLSSHPVAVLLSEKISSVATRTLGNSHNESVTSGQYDISDLIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZIL6</accession>
    <name>A0A074ZIL6_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_08913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596863">
        <property type="protein sequence ID" value="KER23145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009173108.1">
        <property type="nucleotide sequence ID" value="XM_009174844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZIL6"/>
    <dbReference type="GeneID" id="20323092"/>
    <dbReference type="KEGG" id="ovi:T265_08913"/>
    <dbReference type="CTD" id="20323092"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705269" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER23145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="61" mass="7078" checksum="AE9770582A646563" modified="2014-10-01" version="1">MCPYLLYLLIRQSAVSAADPLQCLVSERKDSQKGTQQLYSEQASRQPYTLIPQFRLPEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJP7</accession>
    <name>A0A074ZJP7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596719">
        <property type="protein sequence ID" value="KER27568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168649.1">
        <property type="nucleotide sequence ID" value="XM_009170385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJP7"/>
    <dbReference type="STRING" id="6198.A0A074ZJP7"/>
    <dbReference type="GeneID" id="20319569"/>
    <dbReference type="KEGG" id="ovi:T265_05387"/>
    <dbReference type="CTD" id="20319569"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="233" mass="25323" checksum="FFD8984AF0B05D99" modified="2014-10-01" version="1">MQSTQRSATNPSSTLQLAAARKRDSQVQGLKSRLRMNMTAITENYEMILSRAKVDPNDNPSELGSFAQTEQDTFEMSVRAANIVIRVHESCTGLPDLDGTIIGENPESGISAQEADLLDTSYVATQGSTNPNGNDHVALVGLELPSVHACENLTRLVSEIKQMLILGDFRWLAQITTANAEDLRKRRAHLDRISLRLRDKLVADLYAIEEECAGGGSLFAATAVPPPTTLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZJZ9</accession>
    <name>A0A074ZJZ9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_08505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596841">
        <property type="protein sequence ID" value="KER23650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172590.1">
        <property type="nucleotide sequence ID" value="XM_009174326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZJZ9"/>
    <dbReference type="GeneID" id="20322684"/>
    <dbReference type="KEGG" id="ovi:T265_08505"/>
    <dbReference type="CTD" id="20322684"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER23650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="68" mass="7123" checksum="40286FC17485E574" modified="2014-10-01" version="1">MSETCLIISSVDSDALNALLALVLVASVAVNSDTCFMSQPVPYNSDDIRMNGGSVRIRYGEVSAKGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZK30</accession>
    <name>A0A074ZK30_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_05375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596718">
        <property type="protein sequence ID" value="KER27658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168630.1">
        <property type="nucleotide sequence ID" value="XM_009170366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZK30"/>
    <dbReference type="STRING" id="6198.A0A074ZK30"/>
    <dbReference type="GeneID" id="20319557"/>
    <dbReference type="KEGG" id="ovi:T265_05375"/>
    <dbReference type="CTD" id="20319557"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="58"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KER27658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="205" mass="23062" checksum="5D5BCA642D175D26" modified="2014-10-01" version="1">MHFAPTKCKVLLVDMQSLHMPLTMYSDCSVTGEVNARICKAQIAFANLRHRFVKSAYPCISRLQKELMELLVSSPKGITAFPDGENLTRWLASIQGPDETVYEGQRYKLSLEFGPNYPYSPPTVRFVSRCYHPNVDHQGAICLDILKEKWSPLLTVENLLLSIRSLLAEPNNDSPLNGQAAQLWNNPSAFRIEMLKFQSAATNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZKH9</accession>
    <name>A0A074ZKH9_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">T265_14536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596831">
        <property type="protein sequence ID" value="KER23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009172381.1">
        <property type="nucleotide sequence ID" value="XM_009174117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZKH9"/>
    <dbReference type="STRING" id="6198.A0A074ZKH9"/>
    <dbReference type="GeneID" id="20328702"/>
    <dbReference type="KEGG" id="ovi:T265_14536"/>
    <dbReference type="CTD" id="20328702"/>
    <dbReference type="OrthoDB" id="6236903at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KER23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41294" checksum="5E0A061925DB4E0D" modified="2014-10-01" version="1" fragment="single">INEQISTHIVATKPTAYLLSTSNQIRPTFFISFQKERVRASQLTGARLLLHPRASYPRVAEEGINLMPGTMTDIRFSVYEWSMMEPPHGRCSTSTPVSINFNHVNYSYSEEACHKHVRQLKVVQTCNCLTQSLPIPTELLDRKLDRCEAFRFPATIDLSNNFNTTKQSYFNNDSIARLVQSSRCAEEILTKLDSSATGCRPACVRYTYRPSITAAQWPTKTFLTWFVTKFLKRITTATIRGRPHMTEAEQARVQESLDELQELLSPYEEILNLTRAGKQAEAIQKLMSTEIFERNFLAIVISRPNFDVERVEEKAVVSLTSLFSQIGGLLSIWVGLTFVCIVELVELGLNVADTVLHHRRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZL38</accession>
    <name>A0A074ZL38_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_05044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596708">
        <property type="protein sequence ID" value="KER28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168208.1">
        <property type="nucleotide sequence ID" value="XM_009169944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZL38"/>
    <dbReference type="GeneID" id="20319226"/>
    <dbReference type="KEGG" id="ovi:T265_05044"/>
    <dbReference type="CTD" id="20319226"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="231" mass="25779" checksum="EE17DCC990C4C53D" modified="2014-10-01" version="1">MDPVLDFLDGTLSMDHSVRSALAQSKSDEQTGTSGLSGKKNEDRDTARLPKPRQEQSRYRVRIQTTDLPINKFAPQPLPHLETFLTKNLLYLFTSEAAALVPPVVARKAENSEKAVREWLEGEAVEENKYAKTKQDTGNFSWISQKLEVYKRAVTDIVPRVGARWPKWLEREFADRKARGSNPTSATRLPLSKPGRPGSILAPVLPPGVMAAGHQKGVTAEQLLIILYHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLR4</accession>
    <name>A0A074ZLR4_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_05067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596709">
        <property type="protein sequence ID" value="KER28021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168242.1">
        <property type="nucleotide sequence ID" value="XM_009169978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLR4"/>
    <dbReference type="STRING" id="6198.A0A074ZLR4"/>
    <dbReference type="GeneID" id="20319249"/>
    <dbReference type="KEGG" id="ovi:T265_05067"/>
    <dbReference type="CTD" id="20319249"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="416"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER28021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131017" checksum="DEED476DAA644BC1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZLZ4</accession>
    <name>A0A074ZLZ4_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_04994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168148.1">
        <property type="nucleotide sequence ID" value="XM_009169884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZLZ4"/>
    <dbReference type="GeneID" id="20319176"/>
    <dbReference type="KEGG" id="ovi:T265_04994"/>
    <dbReference type="CTD" id="20319176"/>
    <dbReference type="OrthoDB" id="6239435at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER28081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="397" mass="44626" checksum="312B6FD194F4FDA3" modified="2014-10-01" version="1">MIIDVYGAVVGSTGNIGFSMLSTSCHTMGLTEVADHIFGRRFDTSKWPYLRIIIAVATHEALGLGILVGFWVGCYKFQPLRQIIYRAPDPIRASYDRGMAWSSHKLQRVPAYIKHRTDPQRLLISGAESFVLQFAPRRSVVVSTMFYTRTSPEEFPAKHGSPIELMPTATEIVEYILPGLGVTHHQRGSTLTERTKQNHHHLNGLRIHNYGHKREFLDQKVRGSNSTSVSQLPLSMPGQPGSILALALHLCGTEASHRKGATVKRFFWEVFYGLFVNDRKFCSTSLGVSYHFKQSASGKSSCTAPKPTESISLLQFDCRWQSVTAIRLTIRCCITQIFGPTLDLGAFVRKYNEKKRISSFSEYRSSQWAFRDLLITVELLREVLPSSAIKIPSNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM06</accession>
    <name>A0A074ZM06_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">T265_05003</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:137017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:53185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:56461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:53169"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596707">
        <property type="protein sequence ID" value="KER28091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168157.1">
        <property type="nucleotide sequence ID" value="XM_009169893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM06"/>
    <dbReference type="STRING" id="6198.A0A074ZM06"/>
    <dbReference type="GeneID" id="20319185"/>
    <dbReference type="KEGG" id="ovi:T265_05003"/>
    <dbReference type="CTD" id="20319185"/>
    <dbReference type="OrthoDB" id="5984298at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034479">
        <property type="term" value="F:phosphatidylglycerol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="16">
        <location>
            <begin position="37"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KER28091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="473" mass="54323" checksum="B8478F3C07EBF3D1" modified="2014-10-01" version="1">MLLFILLAVLCCYAALSYILLRFPCLIHRTKPLGPVPVHISHRGGAGERLENTMDAFQNAVSLGTDMLELDCHLTRDSEVVILHDPNLKRITGVDVDVSNVNYNDLPIYLSKLEVEYHPGEFSPKAIILSSKTDANLMLIVHVPRAADSPIFLLPVNVSRLYSMIYLHPADGRVKLSHHCKATPMTDLRFLRLEELLEAFPNVLMNIDIKQDDDRLIQRVAELLQKFHREDLTVWGSFSSVVAAKLQQANPRIKRFFPLEPVLWMFAGYFFGFLPFMSLPYDYLELPLICAFNHKSFATMNCRRLFLNRLTLCSKIPFRTMQYNIKVRNLDPPYLSAKPPIPVYPELQFDVKCRDFVILEQFCTYLRRFLSRLNLDVYIFALPAKLTTYRLYQPNSTNVRTTFVLSDYHRVVRLNGLKAIHLPLLVDLVHQNLPEGVELSLSQSDPKSDDARYVPQLELYALKEELAKLSKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZM99</accession>
    <name>A0A074ZM99_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">T265_04922</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KL596705">
        <property type="protein sequence ID" value="KER28161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168054.1">
        <property type="nucleotide sequence ID" value="XM_009169790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZM99"/>
    <dbReference type="STRING" id="6198.A0A074ZM99"/>
    <dbReference type="GeneID" id="20319104"/>
    <dbReference type="KEGG" id="ovi:T265_04922"/>
    <dbReference type="CTD" id="20319104"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000143">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KER28161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110085" checksum="A9EFD382583562EA" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMN8</accession>
    <name>A0A074ZMN8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_05858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596733">
        <property type="protein sequence ID" value="KER27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169243.1">
        <property type="nucleotide sequence ID" value="XM_009170979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20320040"/>
    <dbReference type="KEGG" id="ovi:T265_05858"/>
    <dbReference type="CTD" id="20320040"/>
    <dbReference type="OrthoDB" id="6242979at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF146">
        <property type="entry name" value="CADHERIN 96CB, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="159"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="419"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="530"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="647"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER27027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="802" mass="89665" checksum="162F8ADF26B32AF1" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZMP0</accession>
    <name>A0A074ZMP0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_04592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596695">
        <property type="protein sequence ID" value="KER28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167631.1">
        <property type="nucleotide sequence ID" value="XM_009169367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZMP0"/>
    <dbReference type="GeneID" id="20318774"/>
    <dbReference type="KEGG" id="ovi:T265_04592"/>
    <dbReference type="CTD" id="20318774"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="83" mass="9767" checksum="7E28AE12C36AA6A1" modified="2014-10-01" version="1">MKVVVRTIVQQIRRRKITCNRSSKKKPGVVGEKPSLRLTWNPAESLVYDVLRQLNVLHQAASCFSRYDILKYRDTCIFVMYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZNN9</accession>
    <name>A0A074ZNN9_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_07512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596792">
        <property type="protein sequence ID" value="KER24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009171313.1">
        <property type="nucleotide sequence ID" value="XM_009173049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZNN9"/>
    <dbReference type="GeneID" id="20321691"/>
    <dbReference type="KEGG" id="ovi:T265_07512"/>
    <dbReference type="CTD" id="20321691"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="300" mass="32289" checksum="B8E7E4020F2266DD" modified="2014-10-01" version="1">MYLTASELQSNEVQTDIYQLPTYETPSQMPNEPHGGGYQQVSSQARILPPGRIPCGFHPQLVAATAEKSIPQNIGQKFGMLVSQASSRELIGRNSGPNSQSQPSIGQMLVANGASQRRQNFQVVTACTKYVLALYSVGRSSQKFTHGRLLSPDGSENADTQTSGAHCRGILCLGPGCCGQLGVKSMKVTTGIRKDKCHSNTDRSTSARDAKFKGHVGIGERGHGIKEQPVEPSDRITNRGQMSSPATSTYINTQVTLLNAQPPTHRYAHLRTDDVTSIGDETFATKLPSSANKPTTIYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP18</accession>
    <name>A0A074ZP18_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_05439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596720">
        <property type="protein sequence ID" value="KER27552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168710.1">
        <property type="nucleotide sequence ID" value="XM_009170446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP18"/>
    <dbReference type="STRING" id="6198.A0A074ZP18"/>
    <dbReference type="GeneID" id="20319621"/>
    <dbReference type="KEGG" id="ovi:T265_05439"/>
    <dbReference type="CTD" id="20319621"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER27552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="245" mass="27922" checksum="3A48D6AF0B498751" modified="2014-10-01" version="1">MLFHRLIRIASIRGYAPFSSRRSPINAPVGSQYERRTRLYYTMALGVAMVGFGYACVPLYRIYCSKVGTGTNSEFARAKTEIIKTMKPVKERQITVHFSADTHSKMAWKFKPVQNEVNINGVYRFLSCPHQFALTVVPGETALAFYSAENPTDRPIIGIATYSIVPTEASKYFNKIQCFCFEEQRLNPHEQVDMPVFFFLDPEFAEDPNLQRTDRIILHYTFFESKSNKMVTPSINSANPVTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP24</accession>
    <name>A0A074ZP24_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_04148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596684">
        <property type="protein sequence ID" value="KER29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167082.1">
        <property type="nucleotide sequence ID" value="XM_009168818.1"/>
    </dbReference>
    <dbReference type="STRING" id="6198.A0A074ZP24"/>
    <dbReference type="GeneID" id="20318334"/>
    <dbReference type="KEGG" id="ovi:T265_04148"/>
    <dbReference type="CTD" id="20318334"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="2834" mass="305773" checksum="6D8D8FBC437A533D" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZP71</accession>
    <name>A0A074ZP71_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_13419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596683">
        <property type="protein sequence ID" value="KER29178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167068.1">
        <property type="nucleotide sequence ID" value="XM_009168804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZP71"/>
    <dbReference type="GeneID" id="20327586"/>
    <dbReference type="KEGG" id="ovi:T265_13419"/>
    <dbReference type="CTD" id="20327586"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER29178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="108" mass="11985" checksum="13397A2AFBF8B4D4" modified="2014-10-01" version="1" fragment="single">RNSTRTRFTAHSQVLLRPRSRSHIRLAKNPGHLPSGPNSQSRPSIGRMLVANGASRTRRNSQKFVSAYATHTKSYTSVVDFVFGVTILCVPLVAVLPWTLAWEAQAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR10</accession>
    <name>A0A074ZR10_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_03641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596671">
        <property type="protein sequence ID" value="KER29848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166440.1">
        <property type="nucleotide sequence ID" value="XM_009168176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR10"/>
    <dbReference type="STRING" id="6198.A0A074ZR10"/>
    <dbReference type="GeneID" id="20317828"/>
    <dbReference type="KEGG" id="ovi:T265_03641"/>
    <dbReference type="CTD" id="20317828"/>
    <dbReference type="OrthoDB" id="6247852at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="323"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER29848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="496" mass="55979" checksum="9E0E589C95E9DBC0" modified="2014-10-01" version="1">MIRRTFSRITRMNFQILYGAYVRPLLEYANQVFYSGRTKDFTLIERVQRAATRMVAGLKSVDYETRLATLDLFPLEYRRLRGDLILTYALFEQSLANRFFTVDPANTRRGHSVSETLGDGEVYMEDDLNEADPAAMDTDPLLNVSTPSHRALAVCFVGLVGLTTFYSTLPAFPESPHAMPYPSSRRLLVFTPSEAPETVATHSSYQEDWHPPFLPGANAKIGYMLGWISSLMYFGSRFPQIFKNWRRRSTEGLCPALFFASILGNTSYGLQIFITSTEPIFLLQALPWLVGSVGVLALDLTATLDKHEACENWRAKDRLRSSLLAIFPCALLGKIVTVTLLDETRVTGRLSSCDGMMNLVLDGGVNIRRRCANSDDEIIRIKEITIFGKRIRYVTIPDTVDVQRSLEKWDFETISSTITLDHSKRMVGRPMRARDRCAALRSRTETVSTKVNENKPVSEANNKASGPLTKDQSLQLDERQHRSVLLPPNFAHETVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZR40</accession>
    <name>A0A074ZR40_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596670">
        <property type="protein sequence ID" value="KER29878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166388.1">
        <property type="nucleotide sequence ID" value="XM_009168124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZR40"/>
    <dbReference type="STRING" id="6198.A0A074ZR40"/>
    <dbReference type="GeneID" id="20327450"/>
    <dbReference type="KEGG" id="ovi:T265_13283"/>
    <dbReference type="CTD" id="20327450"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="446"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="722" mass="78563" checksum="A089359CA0B51EAA" modified="2014-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZRY0</accession>
    <name>A0A074ZRY0_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_06585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
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            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596756">
        <property type="protein sequence ID" value="KER26105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009170152.1">
        <property type="nucleotide sequence ID" value="XM_009171888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZRY0"/>
    <dbReference type="GeneID" id="20320764"/>
    <dbReference type="KEGG" id="ovi:T265_06585"/>
    <dbReference type="CTD" id="20320764"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER26105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="62" mass="7145" checksum="56DE7CCF457B289D" modified="2014-10-01" version="1">MLHILIAGTLIVNEVFEGENKTYVRLHIQQTPFVVSDVMIVRKILLKDLQGYMSTMVARRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSD5</accession>
    <name>A0A074ZSD5_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596662">
        <property type="protein sequence ID" value="KER30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165864.1">
        <property type="nucleotide sequence ID" value="XM_009167600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSD5"/>
    <dbReference type="GeneID" id="20317368"/>
    <dbReference type="KEGG" id="ovi:T265_03181"/>
    <dbReference type="CTD" id="20317368"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="90" mass="9906" checksum="711E266D6862F13D" modified="2014-10-01" version="1">MVQKSRVSPSSGDSPIRHMDDEISEPNDCATNLLIVLHSVPPRDPGESQLDFWVVRNLIWNLPSATSNISIPKFSPQNPQTSEGQTEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZSR7</accession>
    <name>A0A074ZSR7_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">T265_04348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KL596689">
        <property type="protein sequence ID" value="KER28877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167333.1">
        <property type="nucleotide sequence ID" value="XM_009169069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZSR7"/>
    <dbReference type="STRING" id="6198.A0A074ZSR7"/>
    <dbReference type="GeneID" id="20318530"/>
    <dbReference type="KEGG" id="ovi:T265_04348"/>
    <dbReference type="CTD" id="20318530"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704336" description="Glycine cleavage system P protein" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="826"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KER28877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112160" checksum="F3C360A92192AA2F" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZT82</accession>
    <name>A0A074ZT82_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_12267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL600927">
        <property type="protein sequence ID" value="KER18469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009177784.1">
        <property type="nucleotide sequence ID" value="XM_009179520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZT82"/>
    <dbReference type="GeneID" id="20326435"/>
    <dbReference type="KEGG" id="ovi:T265_12267"/>
    <dbReference type="CTD" id="20326435"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER18469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="114" mass="12810" checksum="93A9CB798F9DD9B3" modified="2014-10-01" version="1">MTLQCNKRTVLFESFSVIVVCRCTPGPVRYISPTQLRKHASPAVKKSQLNTTPKTLALKSTPGKSGSKRPLPEESDSEEENHELFPQNGFLKSKVTYSFIRSHIVLYILSERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTD8</accession>
    <name>A0A074ZTD8_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">T265_02916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596657">
        <property type="protein sequence ID" value="KER30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009165544.1">
        <property type="nucleotide sequence ID" value="XM_009167280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTD8"/>
    <dbReference type="STRING" id="6198.A0A074ZTD8"/>
    <dbReference type="GeneID" id="20317104"/>
    <dbReference type="KEGG" id="ovi:T265_02916"/>
    <dbReference type="CTD" id="20317104"/>
    <dbReference type="OrthoDB" id="6275093at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KER30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="99682" checksum="FA58F70D5378E377" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTJ3</accession>
    <name>A0A074ZTJ3_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">T265_06118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KL596741">
        <property type="protein sequence ID" value="KER26685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169568.1">
        <property type="nucleotide sequence ID" value="XM_009171304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTJ3"/>
    <dbReference type="GeneID" id="20320300"/>
    <dbReference type="KEGG" id="ovi:T265_06118"/>
    <dbReference type="CTD" id="20320300"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22593">
        <property type="entry name" value="Kunitz_conkunitzin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF381">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001704322" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="473"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KER26685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="527" mass="60443" checksum="AD894F5E86CEF2CD" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZTU6</accession>
    <name>A0A074ZTU6_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">T265_13406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596682">
        <property type="protein sequence ID" value="KER29222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009167024.1">
        <property type="nucleotide sequence ID" value="XM_009168760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZTU6"/>
    <dbReference type="STRING" id="6198.A0A074ZTU6"/>
    <dbReference type="GeneID" id="20327573"/>
    <dbReference type="KEGG" id="ovi:T265_13406"/>
    <dbReference type="CTD" id="20327573"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000016">
        <property type="entry name" value="26S proteasome regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="253"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KER29222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="451" mass="50526" checksum="212F1FD402EE9293" modified="2014-10-01" version="1" fragment="single">LSIRSESPYRIPEAPPFCQPITLAQTSISTLPTMSAPDVLKAASTEPDPVKRMNIYQNIVRTEVSDPDEVAIKAKEQAILELGNMMAKSSDAKGLADLIVLTRPFLKQISKAKAGRLVRTLVDLFLNLEAGTGREIDLCRECIQWANEERRVFLRQALETRLIGLYYENGHYEEALKLGSTLLRELKKLDDKVLLVEVQLMESQVYYRLGNLQRSRAALTSARTTANGIYCPPRLQASLDLLSGILHAADERDFKTACSYFYEAFEGFDSISSNHAVDALKYMLLSKIMLNCPEEIPNILTGKLALKYNSPHLDAMREVGLAAKNRSLGDFLAVRNKYPVELLEDPVVSRHLNCFYDTLFGQNLLKLIEPYSRVQIGHIAKLINLPLDVVEKKLSQMILDNEHNGILDQGSGVLVLREPQCEGKDYPHALAAVHSLNGIVDMLFQKTTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZV48</accession>
    <name>A0A074ZV48_OPIVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">T265_05704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596728">
        <property type="protein sequence ID" value="KER27240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009169037.1">
        <property type="nucleotide sequence ID" value="XM_009170773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZV48"/>
    <dbReference type="STRING" id="6198.A0A074ZV48"/>
    <dbReference type="GeneID" id="20319886"/>
    <dbReference type="KEGG" id="ovi:T265_05704"/>
    <dbReference type="CTD" id="20319886"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KER27240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="764" mass="82786" checksum="5F216CC35F0376AB" modified="2014-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZVD1</accession>
    <name>A0A074ZVD1_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">T265_05577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596725">
        <property type="protein sequence ID" value="KER27325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009168893.1">
        <property type="nucleotide sequence ID" value="XM_009170629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZVD1"/>
    <dbReference type="GeneID" id="20319759"/>
    <dbReference type="KEGG" id="ovi:T265_05577"/>
    <dbReference type="CTD" id="20319759"/>
    <dbReference type="OrthoDB" id="6246969at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KER27325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="361" mass="41268" checksum="F0E24C31441AC469" modified="2014-10-01" version="1">MCSRPSASRHRKQRFPRLDRRRSYGNPYLRASPLADDCVLSEDEHLFSVNKRFAPVHKPHGSVEAAAVATAPLGNSSPTADTHGGSLPVGRADRRARDEHNEQERNRRRELAVIYELIRCSFSEDDLRYLYPCNTPTSIEKMSYPQVLHVAYHLLREEQHNLIMFERTLNDIRRIEKEFNHAGIPLPERPSLPSITETYLNITEAVDKILKYDKSARAFGGVYEVTPAERAALGDRQLAPLCPRSNPVRHNPIKLPTRFSRLNSHCVRQSVRSTHKPRHSEFPRLTYDEEMSRWDKMVPKLRRSSSSASITRQTSDSEASYLQEYSAARYACKPEDAVSLVFGDSCVQPENDSVVIDFLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW10</accession>
    <name>A0A074ZW10_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">T265_03442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KL596667">
        <property type="protein sequence ID" value="KER30072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009166190.1">
        <property type="nucleotide sequence ID" value="XM_009167926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW10"/>
    <dbReference type="GeneID" id="20317629"/>
    <dbReference type="KEGG" id="ovi:T265_03442"/>
    <dbReference type="CTD" id="20317629"/>
    <dbReference type="OrthoDB" id="6294095at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5001705368" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KER30072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000054324"/>
        </source>
    </evidence>
    <sequence length="100" mass="11338" checksum="956C084615841217" modified="2014-10-01" version="1">MTKTTGVFATFLLLLVICNAKQAQESAAEPKKHDLEQVISEIEVSDPEWETKCPDGDHGHNICHTKGKNWSEFVRSMLRAMSKVAAYILQEKHNHDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-01" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A074ZW35</accession>
    <name>A0A074ZW35_OPIVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">T265_02386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Opisthorchis viverrini</name>
        <name type="common">Southeast Asian liver fluke</name>
        <dbReference type="NCBI Taxonomy" id="6198"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Spiralia</taxon>
            <taxon>Lophotrochozoa</taxon>
            <taxon>Platyhelminthes</taxon>
            <taxon>Trematoda</taxon>
            <taxon>Digenea</taxon>
            <taxon>Opisthorchiida</taxon>
            <taxon>Opisthorchiata</taxon>
            <taxon>Opisthorchiidae</taxon>
            <taxon>Opisthorchis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2013-11" db="EMBL/GenBank/DDBJ databases">
            <title>Opisthorchis viverrini - life in the bile duct.</title>
            <authorList>
                <person name="Young N.D."/>
                <person name="Nagarajan N."/>
                <person name="Lin S.J."/>
                <person name="Korhonen P.K."/>
                <person name="Jex A.R."/>
                <person name="Hall R.S."/>
                <person name="Safavi-Hemami H."/>
                <person name="Kaewkong W."/>
                <person name="Bertrand D."/>
                <person name="Gao S."/>
                <person name="Seet Q."/>
                <person name="Wongkham S."/>
                <person name="Teh B.T."/>
                <person name="Wongkham C."/>
                <person name="Intapan P.M."/>
                <person name="Maleewong W."/>
                <person name="Yang X."/>
                <person name="Hu M."/>
                <person name="Wang Z."/>
                <person name="Hofmann A."/>
                <person name="Sternberg P.W."/>
                <person name="Tan P."/>
                <person name="Wang J."/>
                <person name="Gasser R.B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KL596647">
        <property type="protein sequence ID" value="KER31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009164883.1">
        <property type="nucleotide sequence ID" value="XM_009166619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A074ZW35"/>
    <dbReference type="STRING" id="6198.A0A074ZW35"/>
    <dbReference type="GeneID" id="20316574"/>
    <dbReference type="KEGG" id="ovi:T265_02386"/>
    <dbReference type="CTD" id="20316574"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000054324">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="796"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="869"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    